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BMI1 Gene

protein-coding   GIFtS: 63

GC10P022650
BMI1 polycomb ring finger oncogene
(Previous names: polycomb group ring finger 4, B lymphoma Mo-MLV insertion region 1 homolog (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PCGF4)
Services    

Aliases &
Descriptions
for BMI1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
MGC12685 2
PCGF4 2, 3
RNF51 1, 2, 3
flvi-2/bmi-1 2
Descriptions
B lymphoma Mo-MLV insertion region 1 homolog 2
B lymphoma Mo-MLV insertion region 1 homolog (mouse) 1
BMI1 polycomb ring finger oncogene 2
Polycomb group RING finger protein 4 3
RING finger protein 51 2, 3
murine leukemia viral (bmi-1) oncogene homolog 2
oncogene BMI-1 2
polycomb group protein Bmi1 2
polycomb group ring finger 4 1, 2
External Ids
HGNC: 10661
Entrez Gene: 6482
UniProtKB: P352263
Ensembl: ENSG000001682837
Search outside databases for aliases for BMI1 gene

Previous GC identifers: GC10U990006 GC10P022326 GC10P022760 GC10P022614

Summaries
for BMI1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226
Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to
maintain the transcriptionally repressive state of many genes, including Hox genes, throughout
development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it
mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its
expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase
activity of RNF2/RING2

Gene Wiki entry for BMI1

Genomic Location
for BMI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BMI1 gene  

Entrez Gene cytogenetic band: 10p11.23   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p13

BMI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P022650:     (about GC identifiers)

Start:
 22,650,146 bp from pter
End:
 22,660,194 bp from pter
Size:
 10,049 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  

Proteins
for BMI1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226 (See protein sequence)
Recommended Name: Polycomb complex protein BMI-1  
Size: 326 amino acids; 36949 Da
Subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at
least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1,
RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive
complex 1-like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a
complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1
Subcellular location: Nucleus. Cytoplasm
PDB structures from and Proteopedia :
2H0D (3D)    
Secondary accessions: Q16030 Q96F37

Post-translational modifications:

  • May be polyubiquitinated; which does not lead to proteasomal degradation1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_005171.4  

    ENSEMBL proteins: 
    ENSP00000365851 ENSP00000365881 ENSP00000365909 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Bmi1)
    Human Recombinant Proteins from Abnova (PCGF4)
                  OriGene Purified Recombinant Human Protein: BMI1 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA9367786
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for BMI1: 
    Invitrogen Antibodies for BMI1
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BMI1
    R&D Systems Antibodies for BMI1 (BMI-1)
    Cell Signaling Technology (CST) Antibodies for BMI1 
    Antibodies from Abcam (Bmi1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (PCGF4)
    Novus Biologicals Antibodies for BMI1

    Assays for BMI1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for BMI1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type


       GeneDecks  BMI1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P35226

    ProtoNet protein and cluster: P35226

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226
    Similarity: Contains 1 RING-type zinc finger

    Gene Function
    for BMI1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (BMI1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PCGF4)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005180

                  Applied Biosystems Silencer® siRNAs for BMI1

                  Sigma-Aldrich siRNA and siRNA Panels for BMI1  
                         Sigma-Aldrich shRNA for BMI1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for BMI1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005180
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005180
                                     untagged cDNA clone in CMV expression vector: NM_005180 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005180

    UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226
    Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to
    maintain the transcriptionally repressive state of many genes, including Hox genes, throughout
    development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it
    mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its
    expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase
    activity of RNF2/RING2

    Genatlas biochemistry entry for BMI1:
    bmi-1 protooncogene homolog,activated by Moloney murine leukemia proviral insertion in Emu-myc
    transgenic mouse,polycomb group (PcG) complexing with SSX1 and SSX2 and associating with chromatin

    15/19 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Bmi1) (see all 19 ):

    behavior/neurologicalcellularcraniofacialdigestive/alimentary
    embryogenesisendocrine/exocrine glandgrowth/sizehematopoietic systemimmune system
    lethality-postnatallethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tailnervous system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for BMI1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for BMI1
     Selected targets of Oct-3/4
     Histone modification

       GeneDecks  BMI1 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  BMI1  (Your Favorite Gene powered by Ingenuity) 
     Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

       GeneDecks  BMI1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  BMI1 


    5/52 Interacting proteins for BMI1 (P352262 ENSP000003659093) via UniProtKB, MINT, and/or STRING (see all 52 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX8Q9HC522, ENSP000002693853MINT-4543725 MINT-4543665 MINT-4543674 STRING (score=.932)
    E2F6O754612, ENSP000003021593MINT-19898 STRING (score=.974)
    CBX4O002572, ENSP000002693973MINT-4543631 STRING (score=.965)
    CBX7O959312, ENSP000002161333MINT-4543645 STRING (score=.89)
    RPS27AP629882MINT-6948574
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007379 segment specification TAS7715727
    GO:0010468 regulation of gene expression IMP17420273
    GO:0016568 chromatin modification IEA--
    About this table

    Drugs & Compounds
    for BMI1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BMI1
    1 Novoseek chemical compound relationship for BMI1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 0.00 2 17161394 (1), 9929160 (1)
    About this table

    2 PharmGKB drug compound relationships for BMI1 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mercaptopurinePD  FA  GN  12704389
    methotrexatePD  FA  GN  12704389
    About this table


    Transcripts
    for BMI1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (BMI1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PCGF4)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005180

                  Sigma-Aldrich siRNA and siRNA Panels for BMI1  
                         Sigma-Aldrich shRNA for BMI1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005180  

    REFSEQ mRNAs for BMI1 gene: 

    NM_005180.6   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005180  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005180
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005180
                                     untagged cDNA clone in CMV expression vector: NM_005180 

    Additional cDNA sequence: 

    AK313235.1 BC011652.2 BT019450.1 CR456911.1 L13689.1 

    12 DOTS entries:

    DT.450576  DT.100795561  DT.95271334  DT.95271331  DT.40105884  DT.100795564  DT.121280796  DT.100795567 
    DT.100701596  DT.121280786  DT.91768555  DT.121280792 

    24/520 AceView cDNA sequences (see all 520 ):

    BM785335 CB163576 CA307265 AI133335 BM850672 AI198218 BU678199 AA018146 
    AW068881 AA724394 AA297436 BM468405 BP355879 BC022898 BM819196 T29680 
    BC011652 BP338876 N77409 AA234552 AA322960 BG697708 W32496 AA974180 

    highest scoring ESTs for BMI1:

    L13689 AA037406 AA193571 AA193608 AA281186 AA287795 AA315754 AA322910 AA322960 AA348632 

    Unigene Cluster for BMI1:

    BMI1 polycomb ring finger oncogene
    Hs.380403  [show with all ESTs]
    Unigene Representative Sequence: NM_005180


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BMI1 (see all 10 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
    SP1:              -     -                 -                       -     -                                                               
    SP2:                                      -                       -     -                                                               
    SP3:                                      -           -     -     -     -     -                                                         
    SP4:                    -                 -                                                                                             
    SP5:                                                              -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for BMI1

    3 Ensembl transcripts including schematic representations:
    ENST00000376663  ENST00000376691  ENST00000376719  

    Expression
    for BMI1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BMI1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BMI1

    1 / 2 / 3

    4 probe-sets matching BMI1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		41562_at2, 3 U95-A 1 1.00 1.00 0.97 0.94 L13689 0.80 1.00 0.91 1

    		1728_at2, 3 U95-A 1 1.00 1.00 0.95 1.06 L13689 0.80 1.00 0.91 1

    		202265_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005180 0.60 0.83 0.73 1

    		202265_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTGTATGGG

    SOURCE GeneReport for Unigene cluster: Hs.380403

    Orthologs
    for BMI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for BMI1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 BMI11   -- BMI1 polycomb ring finger oncogene 95.09(n)
    98.77(a)    		 487097  XM_844245.1  XP_849338.1 
    chimpanzee
    (Pan troglodytes)    		 BMI11   -- BMI1 polycomb ring finger oncogene 99.9(n)
    100(a)    		 736264  XM_001136082.1  XP_001136082.1 
    cow
    (Bos taurus)    		 BMI11   -- BMI1 polycomb ring finger oncogene 95.91(n)
    99.08(a)    		 510666  NM_001038072.1  NP_001033161.1 
    rat
    (Rattus norvegicus)    		 Bmi11   -- Bmi1 polycomb ring finger oncogene 89.61(n)
    95.37(a)    		 307151  XM_225606.4  XP_225606.4 
    mouse
    (Mus musculus)    		 Bmi11, 5 2 (9.00 cM)5
    		 Bmi1 polycomb ring finger oncogene1, 5 92.59(n)1
    97.53(a)1    		 121511  NM_007552.41  NP_031578.21 
     AA2173995  AK1454375  (see all 15)
    About this table        Species with no ortholog for BMI1

    ENSEMBL Gene Tree for BMI1

    Paralogs
    for BMI1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BMI1 gene
    PCGF22  PCGF62  PCGF12  

    SNPs/Variants
    for BMI1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/31 NCBI SNPs in BMI1 are shown (see all 31 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 39)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs70800761,2
    		A,C,F,H22659310(+) AACCTA/CTGTTG 1 -- ut314Minor allele frequency- C:0.08EU EA WA 412
    rs79156451,2
    		A,H22658550(+) GCTTTC/ATAGAT 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs79191321,2
    		A,H22658846(+) TTGATC/TGTTCT 1 -- ut314Minor allele frequency- T:0.00EU EA WA 418
    rs10420591,2
    		F,H22655437(+) GATGTG/ATGTGC 1 Y/C mis1 ese35Minor allele frequency- A:0.00MN EU EA WA 590
    rs10420991,2
    		F22659000(+) TGATTC/GCTGTT 1 -- ut31 ese31Minor allele frequency- G:0.01MN 184
    rs11705461,2
    		C22659445(-) ACAATT/CTTTAA 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs110129461,2
    		A,C,F,H22654436(+) GTCCCT/CGGTCC 1 -- int14Minor allele frequency- C:0.06EU EA WA 414
    rs122693921,2
    		F,H22656142(+) TTTTCC/TTAACT 1 -- int1 trp34Minor allele frequency- T:0.02EU EA WA 418
    rs122694721,2
    		H22656250(+) ATTCCC/TTATTC 1 -- int14Minor allele frequency- T:0.00EU EA WA 418
    rs125694291,2
    		H22651366(+) GGTTCC/TCAGTT 1 -- int14Minor allele frequency- T:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for BMI1 (up to first 250kb)

    Disorders & Mutations
    for BMI1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 164831

    UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226
  • Cooperates with the MYC oncogene to produce B-lymphomas

    • 10/34 Novoseek disease relationships for BMI1 gene (see all 34 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma mantle-cell 64.60 3 11389032 (1), 16528373 (1)
    tumors 47.33 89 17545584 (3), 17666329 (3), 16528373 (3), 19215825 (3) (see all 42)
    leukemogenesis 46.21 1 16107895 (1)
    leukemia 46.18 16 19379548 (2), 16963837 (2), 17483039 (2), 10727088 (1) (see all 12)
    cancer 43.76 56 16501599 (6), 17452456 (3), 17711569 (2), 18637271 (2) (see all 26)
    hematologic malignancies 42.52 3 16105758 (1), 15254754 (1), 11289106 (1)
    myeloid leukemia 41.12 2 16963837 (1), 17483039 (1)
    premalignant 33.29 1 15720799 (1)
    breast cancer 32.99 45 18228133 (6), 17545584 (6), 17298744 (5), 17711569 (4) (see all 9)
    carcinoma squamous cell 32.03 11 19215825 (3), 19452584 (2), 19021148 (1), 15720799 (1) (see all 5)
    About this table

    1 PharmGKB disease relationship for BMI1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    About this table

    Medical News
    for BMI1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for BMI1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/188 PubMed articles for BMI1 gene (see all 188 ):

    Search for BMI1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BMI1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 648 HGNC: 1066 AceView: BMI1andCOMMD3 Ensembl:ENSG00000168283 euGenes: HUgn648
    ECgene: BMI1 H-InvDB: BMI1

    Other Databases showing BMI1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing BMI1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for BMI1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for BMI1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BMI1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BMI1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for BMI1 Antibodies for BMI1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BMI1 Browse small molecules at Sigma-Aldrich
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     Antibodies & Assays for BMI1 

     Recombinant Proteins
    (Bmi1)
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     Tagged/untagged cDNA clones
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     Purified proteins from HEK293T cells
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     Search Tocris compounds for BMI1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for BMI1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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