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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BMI1 Gene

protein-coding GIFtS: 65
GCID: GC10P022605

BMI1 polycomb ring finger oncogene

(Previous names: polycomb group ring finger 4, B lymphoma Mo-MLV insertion...)
(Previous symbol: PCGF4)

Explore 62 diseases affiliated with
BMI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BMI1 Polycomb Ring Finger Oncogene¹ ²		FLVI2/BMI1²
PCGF4¹ ² ³		B Lymphoma Mo-MLV Insertion Region 1 Homolog²
RNF51¹ ² ³		Flvi-2/Bmi-1¹
Polycomb Group RING Finger Protein 4² ³		Murine Leukemia Viral (Bmi-1) Oncogene Homolog²
RING Finger Protein 51² ³		Polycomb Complex Protein BMI-1²
B Lymphoma Mo-MLV Insertion Region 1 Homolog (Mouse)¹		Polycomb Group Protein Bmi1²
Polycomb Group Ring Finger 4¹

External Ids:	HGNC: 1066¹	Entrez Gene: 648²	Ensembl: ENSG00000168283⁷	OMIM: 164831⁵	UniProtKB: P35226³

Export aliases for BMI1 gene to outside databases

Previous GC identifers: GC10U990006 GC10P022326 GC10P022760 GC10P022614 GC10P022650

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the

transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts

via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',

rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3

ubiquitin-protein ligase activity of RNF2/RING2

Gene Wiki entry for BMI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BMI1 gene promoter:
Nkx3-1 Nkx3-1 v4 POU3F2 (N-Oct-5a) Nkx3-1 v1 POU3F2 YY1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMI1 promoter sequence

Search SABiosciences Chromatin IP Primers for BMI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.23 Ensembl cytogenetic band: 10p12.2 HGNC cytogenetic band: 10p13

BMI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMI1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P022605: view genomic region (about GC identifiers)

Start:	22,605,381 bp from pter	End:	22,620,414 bp from pter
Size:	15,034 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226 (See protein sequence)

Recommended Name: Polycomb complex protein BMI-1

Size: 326 amino acids; 36949 Da

Subunit: Component of a PRC1-like complex. Interacts with RING1 and RING2 (By similarity). Interacts vwith CBX7 and

CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1

Subcellular location: Nucleus. Cytoplasm

Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different

PRC1-like complexes

2 PDB 3D structures from and Proteopedia for BMI1:

2H0D (3D)

3RPG (3D)

Secondary accessions: Q16030 Q5T8Z3 Q96F37

Explore the universe of human proteins at neXtProt for BMI1: NX_P35226

Post-translational modifications:

Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35226

BMI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005171.4

ENSEMBL proteins:

ENSP00000398759 ENSP00000365851 ENSP00000397912 ENSP00000401773 ENSP00000399220

ENSP00000390768

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: BMI1 OriGene Custom Protein Services for BMI1
	GenScript Custom Purified and Recombinant Proteins Services for BMI1
	Novus Biologicals BMI1 Proteins Novus Biologicals BMI1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BMI1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000151	ubiquitin ligase complex	IDA	16714294
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0016604	nuclear body	IEA	--

BMI1 for ontologies About GeneDecksing

BMI1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BMI1
	R&D Systems Antibodies for BMI1 (BMI-1)
	Cell Signaling Technology (CST) Antibodies for BMI1
	OriGene Antibodies (see all 3): BMI1 OriGene Custom Antibody Services for BMI1
	GenScript Custom Superior Antibodies Services for BMI1
	Novus Biologicals BMI1 Antibodies
	Abcam antibodies for BMI1
	Uscn Antibodies for BMI1
	ThermoFisher Antibody for BMI1

Assay Products for BMI1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for BMI1 (BMI-1)
	GenScript Custom Assay Services for BMI1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BMI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BMI1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR018957 Znf_C3HC4_RING-type

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry P35226

ProtoNet protein and cluster: P35226

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the

transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts

via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',

rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3

ubiquitin-protein ligase activity of RNF2/RING2

Genatlas biochemistry entry for BMI1:

bmi-1 protooncogene homolog,activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic

mouse,polycomb group (PcG) complexing with SSX1 and SSX2 and associating with chromatin

miRNA Products:		miRTarBase miRNAs that target BMI1: hsa-mir-15a (MIRT000280), hsa-mir-128 (MIRT004645), hsa-mir-200c (MIRT000197), hsa-mir-302b (MIRT005670), hsa-mir-16 (MIRT000266)

		OriGene 3'-UTR Clone: BMI1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMI1
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate BMI1 (see all 49):
		hsa-miR-548j hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-218 hsa-miR-508-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: BMI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMI1 (see all 7) OriGene shRNA RFP: BMI1 OriGene siRNA: BMI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMI1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BMI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMI1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMI1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: BMI1 (NM_005180)
		Sino Biological Human cDNA Clone for BMI1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMI1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BMI1
		Search LifeMap BioReagents cell lines for BMI1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMI1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IDA	16714294
GO:0043565	sequence-specific DNA binding	IEA	--

BMI1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for BMI1:

Increased G1 DNA content

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Bmi1^tm1Brn for BMI1
15/18 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Bmi1) (see all 18):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	immune system
limbs/digits/tail	mortality/aging	nervous system	normal	respiratory system

BMI1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Protein Stability

Protein Stability

1.00

Neuroscience

Neuroscience

1.00

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for BMI1

	Selected targets of Oct-3/4
	Histone modification

5 Cell Signaling Technology (CST) Pathways for BMI1

	Chromatin Regulation / Acetylation
	Wnt / Hedgehog / Notch
	Neuroscience
	Lymphocyte Signaling
	Protein Stability

2 BioSystems Pathways for BMI1

	Senescence and Autophagy
	Validated targets of C-MYC transcriptional activation

BMI1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BMI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/105 Interacting proteins for BMI1 (P35226^{1, 2, 3} ENSP00000365851⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP11	P51784²^,³, ENSP00000218348⁴	MINT-7999702 MINT-8001998 MINT-8001923 MINT-7998977 MINT-8001946 MINT-8010211 MINT-8000588 MINT-8001976 MINT-8010325 I2D: score=2 STRING: ENSP00000218348
CBX8	Q9HC52¹^,²^,³, ENSP00000269385⁴	EBI-2341576,EBI-712912 MINT-8001998 MINT-8001923 MINT-4543665 MINT-8001946 MINT-4543725 MINT-8001976 MINT-8010325 MINT-4543674 I2D: score=3 STRING: ENSP00000269385
USP7	Q93009²^,³, ENSP00000343535⁴	MINT-8001998 MINT-7999691 MINT-8001923 MINT-8001946 MINT-8000588 MINT-8001976 MINT-8010220 MINT-7999056 I2D: score=2 STRING: ENSP00000343535
RING1	Q06587¹^,²^,³, ENSP00000363787⁴	EBI-2341576,EBI-752313 MINT-8001946 MINT-8010325 I2D: score=3 STRING: ENSP00000363787
CBX4	O00257-3¹, ENSP00000269397⁴	EBI-2341576,EBI-4392727 MINT-8010325 MINT-4543631 I2D: score=2 STRING: ENSP00000269397

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	19636380
GO:0001501	skeletal system development	--	--
GO:0001701	in utero embryonic development	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006959	humoral immune response	IEA	--

BMI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BMI1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BMI1
2 Novoseek chemical compound relationships for BMI1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	0	2	17161394 (1), 9929160 (1)
estrogen	0	2	15454193 (1), 17298744 (1)

Search CenterWatch for drugs/clinical trials and news about BMI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BMI1 gene:

NM_005180.8

Unigene Cluster for BMI1:

BMI1 polycomb ring finger oncogene

Hs.380403 [show with all ESTs]

Unigene Representative Sequence: NM_005180

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000417470 ENST00000376663(uc009xkg.3 uc001irh.3) ENST00000442508

ENST00000456675 ENST00000416820 ENST00000443519 ENST00000496174 ENST00000490311

miRNA Products:		OriGene 3'-UTR Clone: BMI1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMI1
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate BMI1 (see all 49):
		hsa-miR-548j hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-218 hsa-miR-508-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: BMI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMI1 (see all 7) OriGene shRNA RFP: BMI1 OriGene siRNA: BMI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMI1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMI1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMI1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: BMI1 (NM_005180)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMI1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BMI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMI1

Additional cDNA sequence:

AH004292.1 BC011652.2 BT019450.1 CR456911.1 L13689.1

11 DOTS entries:

DT.450576 DT.100795561 DT.95271334 DT.100795564 DT.121280796 DT.100795567 DT.95271331 DT.100701596

DT.121280786 DT.121280792 DT.40105884

24/520 AceView cDNA sequences (see all 520):

AI360621 CB163576 BX381264 AA974180 CF128831 AA297436 C00368 BM819196

BQ022251 AA297868 AI075362 BM697341 BM048894 CR596018 AY542159 AI133335

AI929429 BM785335 BP352910 AI916726 BE222943 NM_005180 AI362205 BQ051614

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BMI1 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13
SP1:					-		-						-								-		-
SP2:													-								-		-
SP3:													-				-		-		-		-		-
SP4:							-						-
SP5:																					-		-

ECgene alternative splicing isoforms for BMI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BMI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTATGGG

About this image

BMI1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Spinal Neural Tube Cells

Neural Ectoderm

Lung

Tracheal Cartilage

Lung

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)

Epithelium, Kidney

Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)

Epithelium, Kidney

Renal embryonic cells (CD24+CD133+ REC) (Renal multipotent pr...)

Kidney

See BMI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BMI1

SOURCE GeneReport for Unigene cluster: Hs.380403

SABiosciences Expression via Pathway-Focused PCR Arrays including BMI1 (see all 6):

Polycomb & Trithorax Complexes in human mouse rat

Cancer PathwayFinder in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Cellular Senescence in human mouse rat

Epigenetic Chromatin Remodeling Factors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BMI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMI1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for BMI1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	BMI1⁶	--	88(a)	1 ↔ 1	6(16337346-16342111)
zebrafish (Danio rerio)	Actinopterygii	bmi1b¹	B lymphoma Mo-MLV insertion region 1b	72.41(n) 78.68(a)		394249 NM_001080751.1 NP_001074220.1
fruit fly (Drosophila melanogaster)	Insecta	Psc³	negative regulation of transcription by homeotic more	44(a)		2 49E6 --
worm (Caenorhabditis elegans)	Secernentea	mig-32⁶	Protein MIG-32, isoform a	9(a)	possible ortholog	IV(12089225-12092191)
thale cress (Arabidopsis thaliana)	eudicotyledons	DRIP2⁶ AT3G23060⁶ (see all 3)	putative E3 ubiquitin protein ligase DRIPH (see all 3)	12(a) 11(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(13026000-13030661) 3(8200636-8203233)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	zinc finger, C3HC4 type domain containing protein,... zinc finger, C3HC4 type domain containing protein,... (see all 4)	14(a) 12(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(33260062-33265172) 3(30433004-30438158)

ENSEMBL Gene Tree for BMI1 (if available)
TreeFam Gene Tree for BMI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BMI1 gene

PCGF5² PCGF2² PCGF6² PCGF1² PCGF3²

18/21 SIMAP similar genes for BMI1 using alignment to 6 protein entries: BMI1_HUMAN (see all proteins) (see all similar genes):

COMMD3 PCGF2 PCGF1 PCGF3 PCGF6 TRIM35

PCGF5 TRIM64C TRAIP TRIM64 TRIM64B TRIM31

TRIM73 RAD18 TRIM39 TRIM21 CHFR TRIM51

BMI1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for BMI1
PGOHUM00000241366

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60602527^1,2	C,	--	22608171(+)	`CTGTTC/GTTGCT`	3	--	int¹ us2k¹		2		WA	120
rs144347963^1,2		--	22608261(+)	`TAAGAA/GCATGG`	3	--	int¹ us2k¹		0	--	--	--	--
rs1125094^1,2	C,F,H,	--	22608284(-)	`TGAAAG/CCAAAG`	3	--	int¹ us2k¹		6		MN NS EA WA	720
rs188525279^1,2		--	22608317(+)	`ATTGGA/GTTTTG`	3	--	int¹ us2k¹		0	--	--	--	--
rs148761047^1,2		--	22608650(+)	`AATCAC/TGTTTC`	3	--	int¹ us2k¹		0	--	--	--	--
rs181248798^1,2		--	22608657(+)	`TTTCAA/GTGTGA`	3	--	int¹ us2k¹		0	--	--	--	--
rs143910449^1,2		--	22608724(+)	`ATAGTA/GGTTTG`	3	--	int¹ us2k¹		0	--	--	--	--
rs186281665^1,2		--	22608795(+)	`TCTTGC/GATCTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs74584445^1,2	C,F,	--	22608826(+)	`TTCCAT/CGTTTT`	3	--	int¹ us2k¹		3		CSA WA	122
rs12412271^1,2	C,H	--	22608829(+)	`CATGTT/GTTATC`	3	--	us2k¹ int¹ tfbs³		4		NS EA	524

HapMap Linkage Disequilibrium report for BMI1 (22605381 - 22620414 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BMI1
1 CNV: 70935
Human Gene Mutation Database (HGMD): BMI1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMI1

DNA2.0 Custom Variant and Variant Library Synthesis for BMI1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BMI1 for disorders           About GeneDecksing

OMIM gene information: 164831    OMIM disorders: --

20/62 diseases for BMI1 (see all 62):    About MalaCards

b-cell non-hodgkin lymphoma non-hodgkin lymphoma leukemia graft versus host disease

mycosis fungoides myeloid leukemia primary biliary cirrhosis squamous cell carcinoma

renal clear cell carcinoma hodgkin's lymphoma burkitt's lymphoma b-cell lymphomas

mantle cell lymphoma squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma pancreatic ductal adenocarcinoma

synovial sarcoma myelodysplastic syndrome lymphosarcoma acute lymphoblastic leukemia

1 disease from the University of Copenhagen DISEASES database for BMI1:

Cancer

10/35 Novoseek disease relationships for BMI1 gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma mantle-cell	61.7	3	11389032 (1), 16528373 (1)
tumors	52	113	19659474 (4), 20377880 (3), 17666329 (3), 17545584 (3) (see all 53)
cancer	51.1	79	16501599 (6), 17452456 (3), 20170541 (2), 17711569 (2) (see all 36)
leukemia	48	23	19379548 (2), 20428793 (2), 17483039 (2), 16963837 (2) (see all 17)
leukemogenesis	42.8	1	16107895 (1)
hematologic malignancies	38.6	3	16105758 (1), 15254754 (1), 11289106 (1)
myeloid leukemia	37.8	2	16963837 (1), 17483039 (1)
breast cancer	36.1	56	18228133 (6), 17545584 (6), 17298744 (6), 17711569 (4) (see all 13)
carcinoma squamous cell	32.3	11	19215825 (3), 19452584 (2), 19021148 (1), 15720799 (1) (see all 5)
medulloblastoma	30.5	6	15029199 (3), 17452456 (2)

Export disorders for BMI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BMI1 gene, integrated from 9 sources (see all 329):
(articles sorted by number of sources associating them with BMI1)

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Characterization and chromosomal localization of the human proto- oncogene BMI-1. (PubMed id 8268912)^{1, 2, 3, 9} Alkema M.J.... van Lohuizen M. (1993)
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PubMed id 9121482)^{1, 2, 9} Gunster M.J.... Otte A.P. (1997)
Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)^{1, 2, 9} Maertens G.N....Peters G. (2009)
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PubMed id 16714294)^{1, 2, 9} Li Z....Xu R.M. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. (PubMed id 15897469)^{1, 2} Hernandez-Munoz I....van Lohuizen M. (2005)
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)^{1, 2} Cao R.... Zhang Y. (2005)
Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)^{1, 2} Wang H.... Zhang Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)^{1, 2} Levine S.S....Kingston R.E. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 648	HGNC: 1066	AceView: BMI1andCOMMD3	Ensembl:ENSG00000168283	euGenes: HUgn648
ECgene: BMI1	H-InvDB: BMI1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BMI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BMI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BMI1 gene:
Search GeneIP for patents involving BMI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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