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BMI1 Gene

protein-coding   GIFtS: 65
GCID: GC10P022611

BMI1 Polycomb Ring Finger Oncogene

(Previous names: polycomb group ring finger 4, B lymphoma Mo-MLV insertion...)
(Previous symbol: PCGF4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BMI1 Polycomb Ring Finger Oncogene1 2     FLVI2/BMI12
PCGF41 2 3     B Lymphoma Mo-MLV Insertion Region 1 Homolog2
Polycomb Group RING Finger Protein 42 3     flvi-2/bmi-12
RING Finger Protein 512 3     Murine Leukemia Viral (Bmi-1) Oncogene Homolog2
RNF512 3     Polycomb Complex Protein BMI-12
B Lymphoma Mo-MLV Insertion Region 1 Homolog (Mouse)1     Polycomb Group Protein Bmi12
Polycomb Group Ring Finger 41     

External Ids:    HGNC: 10661   Entrez Gene: 6482   Ensembl: ENSG000001682837   OMIM: 1648315   UniProtKB: P352263   

Export aliases for BMI1 gene to outside databases

Previous GC identifers: GC10U990006 GC10P022326 GC10P022760 GC10P022614 GC10P022650 GC10P022605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BMI1 Gene:
BMI1 (BMI1 polycomb ring finger oncogene) is a protein-coding gene. Diseases associated with BMI1 include embryonal cancer, and erythroplakia. GO annotations related to this gene include RING-like zinc finger domain binding. An important paralog of this gene is PCGF5.

UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to
stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2

Gene Wiki entry for BMI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMI1 gene promoter:
         Nkx3-1   Nkx3-1 v4   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   YY1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMI1 promoter sequence
   Search Chromatin IP Primers for BMI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.23   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p13

BMI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMI1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P022611:  view genomic region     (about GC identifiers)

Start:
22,610,139 bp from pter      End:
22,620,414 bp from pter
Size:
10,276 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226 (See protein sequence)
Recommended Name: Polycomb complex protein BMI-1  
Size: 326 amino acids; 36949 Da
Subunit: Component of a PRC1-like complex. Interacts with RING1 and RING2 (By similarity). Interacts vwith CBX7
and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
2 PDB 3D structures from and Proteopedia for BMI1:
2H0D (3D)        3RPG (3D)    
Secondary accessions: Q16030 Q5T8Z3 Q96F37

Explore the universe of human proteins at neXtProt for BMI1: NX_P35226

Explore proteomics data for BMI1 at MOPED

Post-translational modifications: 

  • Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation1
  • Ubiquitination2 at Lys73
  • Modification sites at PhosphoSitePlus

  • See BMI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005171.4  
    ENSEMBL proteins: 
     ENSP00000365851   ENSP00000397912   ENSP00000399220   ENSP00000390768  
    Reactome Protein details: P35226

    BMI1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BMI1
    OriGene Protein Over-expression Lysate for BMI1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BMI1
    GenScript Custom Purified and Recombinant Proteins Services for BMI1
    Novus Biologicals BMI1 Proteins
    Novus Biologicals BMI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    BMI1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BMI1
    R&D Systems Antibodies for BMI1 (BMI-1)
    Cell Signaling Technology (CST) Antibodies for BMI1 
    OriGene Antibodies for BMI1
    OriGene Custom Antibody Services for BMI1
    Novus Biologicals BMI1 Antibodies
    Abcam antibodies for BMI1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for BMI1
    LSBio Antibodies in human, mouse, rat for BMI1

    BMI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BMI1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BMI1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    PCGF: Polycomb group ring fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry P35226

    ProtoNet protein and cluster: P35226

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: BMI1_HUMAN, P35226
    Similarity: Contains 1 RING-type zinc finger


    BMI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMI1_HUMAN, P35226
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to
    stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2

         Genatlas biochemistry entry for BMI1:
    bmi-1 protooncogene homolog,activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic
    mouse,polycomb group (PcG) complexing with SSX1 and SSX2 and associating with chromatin

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15386022
    GO:0008270zinc ion binding IDA16714294
    GO:0046872metal ion binding ----
    GO:0071535RING-like zinc finger domain binding IPI16714294
         
    BMI1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BMI1:
     Increased G1 DNA content  Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bmi1) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging  nervous system  normal  respiratory system 

    BMI1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bmi1tm1Brn for BMI1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BMI1:
    hsa-mir-128-3p (MIRT004645), hsa-mir-27a-3p (MIRT050022), hsa-mir-106b-3p (MIRT038596), hsa-mir-16-5p (MIRT000266), hsa-mir-15a-5p (MIRT000280), hsa-mir-194-5p (MIRT007000), hsa-mir-33a-5p (MIRT028182), hsa-mir-200c-3p (MIRT000197), hsa-mir-302b-3p (MIRT005670), hsa-mir-218-5p (MIRT007258), hsa-let-7g-5p (MIRT024120)

    Block miRNA regulation of human, mouse, rat BMI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMI1 (see all 49):
    hsa-miR-548j hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-218 hsa-miR-508-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidBMI1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BMI1
    Predesigned siRNA for gene silencing in human, mouse, rat BMI1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for BMI1

    Clone
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    OriGene clones in human, mouse for BMI1 (see all 6)
    OriGene ORF clones in mouse, rat for BMI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMI1 (NM_005180)
    Sino Biological Human cDNA Clone for BMI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMI1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BMI1
    Browse ESI BIO Cell Lines and PureStem Progenitors for BMI1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMI1_HUMAN, P35226: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16714294
    GO:0005634nucleus IDA10445843
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IEA--

    BMI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMI1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    2Packaging Of Telomere Ends
    Histone modification0.31
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    5Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 Cell Signaling Technology (CST) Pathways for BMI1
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch
    Neuroscience
    Lymphocyte Signaling
    Protein Stability

    2 BioSystems Pathways for BMI1
        Senescence and Autophagy
    Validated targets of C-MYC transcriptional activation


    1 Reactome Pathway for BMI1
        Oxidative Stress Induced Senescence


    2 Kegg Pathways  (Kegg details for BMI1):
        Transcriptional misregulation in cancer
    MicroRNAs in cancer


    BMI1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMI1 (see all 6): 
              Polycomb & Trithorax Complexes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BMI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BMI1 (P352261, 2, 3 ENSP000003658514) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP11P517841, 2, 3, ENSP000002183484EBI-2341576,EBI-306876 MINT-7999702 MINT-8001998 MINT-8001923 MINT-7998977 MINT-8001946 MINT-8010211 MINT-8000588 MINT-8001976 MINT-8010325 I2D: score=2 STRING: ENSP00000218348
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-2341576,EBI-752313 MINT-8001946 MINT-8010325 I2D: score=3 STRING: ENSP00000396439
    RING1Q065871, 2, 3, ENSP000003637874EBI-2341576,EBI-752313 MINT-8001946 MINT-8010325 I2D: score=3 STRING: ENSP00000363787
    CBX8Q9HC521, 2, 3, ENSP000002693854EBI-2341576,EBI-712912 MINT-8001998 MINT-8001923 MINT-4543665 MINT-8001946 MINT-4543725 MINT-8001976 MINT-8010325 MINT-4543674 I2D: score=3 STRING: ENSP00000269385
    USP7Q930091, 2, 3, ENSP000003435354EBI-2341576,EBI-302474 MINT-8001998 MINT-7999691 MINT-8001923 MINT-8001946 MINT-8000588 MINT-8001976 MINT-8010220 MINT-7999056 I2D: score=2 STRING: ENSP00000343535
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP19636380
    GO:0006351transcription, DNA-templated IEA--
    GO:0007379segment specification TAS7715727
    GO:0010468regulation of gene expression IMP17420273
    GO:0016568chromatin modification IEA--

    BMI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMI1

    2 Novoseek inferred chemical compound relationships for BMI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 0 2 17161394 (1), 9929160 (1)
    estrogen 0 2 15454193 (1), 17298744 (1)



    BMI1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BMI1 gene: 
    NM_005180.8  

    Unigene Cluster for BMI1:

    BMI1 polycomb ring finger oncogene
    Hs.380403  [show with all ESTs]
    Unigene Representative Sequence: NM_005180
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376663(uc009xkg.3 uc001irh.3) ENST00000602523 ENST00000456675
    ENST00000442508 ENST00000416820 ENST00000602358 ENST00000602524 ENST00000443519
    ENST00000496174 ENST00000490311
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat BMI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMI1 (see all 49):
    hsa-miR-548j hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-218 hsa-miR-508-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidBMI1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BMI1
    Predesigned siRNA for gene silencing in human, mouse, rat BMI1
    Clone
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    OriGene clones in human, mouse for BMI1 (see all 6)
    OriGene ORF clones in mouse, rat for BMI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMI1 (NM_005180)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMI1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BMI1
    OriGene qSTAR qPCR primer pairs in human, mouse for BMI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMI1
      QuantiTect SYBR Green Assays in human, mouse, rat BMI1
      QuantiFast Probe-based Assays in human, mouse, rat BMI1

    Additional mRNA sequence: 

    AH004292.1 BC011652.2 BT019450.1 CR456911.1 L13689.1 

    11 DOTS entries:

    DT.450576  DT.100795561  DT.95271334  DT.100795564  DT.121280796  DT.100795567  DT.95271331  DT.100701596 
    DT.121280786  DT.121280792  DT.40105884 

    Selected AceView cDNA sequences (see all 520):

    N67528 BM697341 BM667975 BM971151 AA297949 BQ022251 AU135308 BM714237 
    CR612205 AL599415 BM819196 BM468405 BE008628 BP352910 AA026494 CR625344 
    BF445641 AA524024 BQ613919 BQ271761 BQ272082 AA026417 AA297436 AW273052 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BMI1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
    SP1:              -     -                 -                       -     -                                                               
    SP2:                                      -                       -     -                                                               
    SP3:                                      -           -     -     -     -     -                                                         
    SP4:                    -                 -                                                                                             
    SP5:                                                              -     -                                                               


    ECgene alternative splicing isoforms for BMI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTATGGG
    BMI1 Expression
    About this image


    BMI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Lens
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             Parietal epithelial cells (PEC)
             Renal embryonic cells (CD24+CD133+ REC)
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    BMI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380403
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMI1 (see all 6): 
              Polycomb & Trithorax Complexes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Cellular Senescence in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BMI1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmi15 Bmi1 polycomb ring finger oncogene   --   2 (12.90 cM) 18677018 
    chicken
    (Gallus gallus)
    Aves BMI16
    Gallus gallus BMI1 polycomb ring finger oncogene (...
    95(a)
    1 → many
    2(17614781-17620068)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 → many
    6(16337346-16348628)
    zebrafish
    (Danio rerio)
    Actinopterygii bmi1a1 B lymphoma Mo-MLV insertion region 1a 73.33(n)
    82.5(a)
      321505  NM_194366.1  NP_919347.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Psc3 negative regulation of transcription by
    homeotic more
    44(a)   2 49E6   --


    ENSEMBL Gene Tree for BMI1 (if available)
    TreeFam Gene Tree for BMI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BMI1 gene
    PCGF52  PCGF22  PCGF62  PCGF12  COMMD3-BMI12  PCGF32  
    Selected SIMAP similar genes for BMI1 using alignment to 5 protein entries:     BMI1_HUMAN (see all proteins) (see all similar genes):
    COMMD3-BMI1    COMMD3    PCGF2    PCGF1    PCGF3    PCGF5
    PCGF6    TRIM35    TRIM64C    TRAIP    TRIM64    TRIM64B
    TRIM31    TRIM73    RAD18    TRIM39    TRIM21    CHFR

    BMI1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BMI1
    PGOHUM00000241366


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for BMI1    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10420591,2,4
    ----see VAR_0520872 mis40--------

    HapMap Linkage Disequilibrium report for BMI1 (22610139 - 22620414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BMI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv894959CNV Loss21882294
    dgv624n71CNV Loss21882294
    dgv625n71CNV Loss21882294
    esv27808CNV Gain19812545
    nsv825300CNV Gain20364138
    dgv136n67CNV Gain20364138
    dgv137n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): BMI1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMI1
    DNA2.0 Custom Variant and Variant Library Synthesis for BMI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164831    OMIM disorders: --

    Selected diseases for BMI1 (see all 69):    
    About MalaCards
    embryonal cancer    erythroplakia    juvenile nasopharyngeal angiofibroma    oral leukoplakia
    lymphosarcoma    tongue cancer    chronic myeloid leukemia    nasopharyngitis
    leukoplakia    acute graft versus host disease    burkitt's lymphoma    lung adenocarcinoma
    acute leukemia    myelodysplastic syndromes    squamous cell carcinoma of the head and neck    medulloblastoma
    renal clear cell carcinoma    mantle cell lymphoma    mycosis fungoides    synovial sarcoma

    1 disease from the University of Copenhagen DISEASES database for BMI1:
    Cancer

    BMI1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BMI1 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma mantle-cell 61.7 3 11389032 (1), 16528373 (1)
    tumors 52 113 19659474 (4), 20377880 (3), 17666329 (3), 17545584 (3) (see all 53)
    cancer 51.1 79 16501599 (6), 17452456 (3), 20170541 (2), 17711569 (2) (see all 36)
    leukemia 48 23 19379548 (2), 20428793 (2), 17483039 (2), 16963837 (2) (see all 17)
    leukemogenesis 42.8 1 16107895 (1)
    hematologic malignancies 38.6 3 16105758 (1), 15254754 (1), 11289106 (1)
    myeloid leukemia 37.8 2 16963837 (1), 17483039 (1)
    breast cancer 36.1 56 18228133 (6), 17545584 (6), 17298744 (6), 17711569 (4) (see all 13)
    carcinoma squamous cell 32.3 11 19215825 (3), 19452584 (2), 19021148 (1), 15720799 (1) (see all 5)
    medulloblastoma 30.5 6 15029199 (3), 17452456 (2)


    Export disorders for BMI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMI1 gene, integrated from 10 sources (see all 373):
    (articles sorted by number of sources associating them with BMI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal localization of the human proto- oncogene BMI-1. (PubMed id 8268912)1, 2, 3, 9 Alkema M.J.... van Lohuizen M. (Hum. Mol. Genet. 1993)
    2. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PubMed id 9121482)1, 2, 9 Gunster M.J.... Otte A.P. (Mol. Cell. Biol. 1997)
    3. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2, 9 Maertens G.N.... Peters G. (PLoS ONE 2009)
    4. Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PubMed id 16714294)1, 2, 9 Li Z.... Xu R.M. (J. Biol. Chem. 2006)
    5. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    6. Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. (PubMed id 15897469)1, 2 Hernandez-Munoz I....van Lohuizen M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (Mol. Cell 2005)
    8. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 648 HGNC: 1066 AceView: BMI1andCOMMD3 Ensembl:ENSG00000168283 euGenes: HUgn648
    ECgene: BMI1 Kegg: 648 H-InvDB: BMI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BMI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BMI1 gene:
    Search GeneIP for patents involving BMI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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