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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BMF Gene

protein-coding GIFtS: 59
GCID: GC15M040380

Bcl2 modifying factor

Explore 15 diseases affiliated with
BMF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bcl2 Modifying Factor¹ ²
FLJ00065¹
Bcl-2-Modifying Factor²

External Ids:	HGNC: 24132¹	Entrez Gene: 90427²	Ensembl: ENSG00000104081⁷	OMIM: 606266⁵	UniProtKB: Q96LC9³

Export aliases for BMF gene to outside databases

Previous GC identifers: GC15M035747 GC15M033275 GC15M037959 GC15M038096 GC15M038167 GC15M017223

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMF:

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and

act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein

contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic

activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2,

which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript

variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9

Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator

Gene Wiki entry for BMF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BMF gene promoter:
E2F-3a E2F-4 E2F-1 E2F IRF-7A E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BMF promoter sequence

Search SABiosciences Chromatin IP Primers for BMF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q14

BMF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMF gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M040380: view genomic region (about GC identifiers)

Start:	40,380,091 bp from pter	End:	40,401,093 bp from pter
Size:	21,003 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9 (See protein sequence)

Recommended Name: Bcl-2-modifying factor

Size: 184 amino acids; 20508 Da

Subunit: Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor

complex through its binding to DLC2 (By similarity)

Sequence caution: Sequence=AAH60783.1; Type=Erroneous initiation; Sequence=BAB15762.1; Type=Erroneous initiation;

Secondary accessions: Q2M396 Q6NT30 Q6NT56 Q6P9F6 Q7Z7D4 Q7Z7D5 Q9H7K7

Alternative splicing: 3 isoforms: Q96LC9-1 Q96LC9-2 Q96LC9-3

Explore the universe of human proteins at neXtProt for BMF: NX_Q96LC9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96LC9

BMF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001003940.1 NP_001003942.1 NP_277038.1 NP_001003943.1

ENSEMBL proteins:

ENSP00000346697 ENSP00000380703 ENSP00000453892 ENSP00000453522 ENSP00000453913

ENSP00000396511 ENSP00000453919 ENSP00000454142 ENSP00000452660 ENSP00000220446

Reactome Protein details: Q96LC9
Human Recombinant Protein Products:

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	Novus Biologicals BMF Proteins Novus Biologicals BMF Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for BMF
	Uscn Proteins for BMF

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001669	acrosomal vesicle	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--

BMF for ontologies About GeneDecksing

BMF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BMF
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	Novus Biologicals BMF Antibodies
	Abcam antibodies for BMF
	Uscn Antibodies for BMF
	ThermoFisher Antibodies for BMF

Assay Products for BMF:

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	Uscn ELISAs and CLIAs for BMF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96LC9

UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9

Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator

miRNA Products:		miRTarBase miRNAs that target BMF: hsa-mir-125b (MIRT003394), hsa-mir-221 (MIRT000141)

		OriGene 3'-UTR Clone (see all 4): BMF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMF
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate BMF (see all 80):
		hsa-miR-1914* hsa-miR-10b* hsa-miR-761 hsa-miR-374b* hsa-miR-4324 hsa-miR-1266 hsa-miR-4306 hsa-miR-1

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMF (see all 7) OriGene shRNA RFP: BMF OriGene siRNA: BMF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BMF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 4): BMF (NM_001003940)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BMF
		Search LifeMap BioReagents cell lines for BMF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMF

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11546872

BMF for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BMF:

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-outs for BMF: Bmf^tm1.1Anvi Bmf^tm1Rjd Bmf^tm4.1Rjd
10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Bmf):

cellular	growth/size	hematopoietic system	immune system	limbs/digits/tail
mortality/aging	no phenotypic analysis	normal	reproductive system	tumorigenesis

BMF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1.00	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins	0.24
Activation of BH3-only proteins	0.30	Intrinsic Pathway for Apoptosis	0.23
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	0.24

Apoptosis and survival_Caspase cascade

Apoptosis and survival_FAS signaling cascades

0.44

Apoptosis and survival FAS signaling cascades

0.44

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Activation of BMF and translocation to mitochondria

Activation of BMF and translocation to mitochondria

1.00

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for BMF

	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

1 Cell Signaling Technology (CST) Pathway for BMF

Apoptosis and Autophagy

2 GeneGo (Thomson Reuters) Pathways for BMF

	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

2 BioSystems Pathways for BMF

	Apoptosis Modulation and Signaling
	Androgen receptor signaling pathway

5 Reactome Pathways for BMF

	Activation of BH3-only proteins
	Activation of BMF and translocation to mitochondria
	Intrinsic Pathway for Apoptosis
	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
	Apoptosis

BMF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BMF

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/16 Interacting proteins for BMF (Q96LC9³ ENSP00000346697⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL2L2	Q92843³, ENSP00000250405⁴	I2D: score=5 STRING: ENSP00000250405
BCL2	P10415³, ENSP00000329623⁴	I2D: score=5 STRING: ENSP00000329623
BCL2L2-PABPN1	Q92843³	I2D: score=5
BCL2L1	Q07817³, ENSP00000302564⁴	I2D: score=3 STRING: ENSP00000302564
MAPK8	P45983³, ENSP00000353483⁴	I2D: score=2 STRING: ENSP00000353483

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0008633	activation of pro-apoptotic gene products	--	--
GO:0032464	positive regulation of protein homooligomerization	ISS	--
GO:0042981	regulation of apoptotic process	--	--
GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISS	--

BMF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BMF
Search CenterWatch for drugs/clinical trials and news about BMF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BMF gene (4 alternative transcripts):

NM_001003940.1 NM_001003942.1 NM_033503.3 NM_001003943.2

Unigene Cluster for BMF:

Bcl2 modifying factor

Hs.591104 [show with all ESTs]

Unigene Representative Sequence: NM_001003940

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354670(uc001zkt.3 uc001zku.3 uc001zkw.3) ENST00000397573(uc001zkv.3)

ENST00000561360 ENST00000561282 ENST00000558774 ENST00000431415 ENST00000559701

ENST00000557870 ENST00000560430 ENST00000558057 ENST00000220446

miRNA Products:		OriGene 3'-UTR Clone (see all 4): BMF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMF
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate BMF (see all 80):
		hsa-miR-1914* hsa-miR-10b* hsa-miR-761 hsa-miR-374b* hsa-miR-4324 hsa-miR-1266 hsa-miR-4306 hsa-miR-1

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMF (see all 7) OriGene shRNA RFP: BMF OriGene siRNA: BMF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMF (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMF (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): BMF (NM_001003940)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BMF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMF

Additional cDNA sequence:

AK024472.1 AY029254.1 AY222040.1 AY222041.1 BC060783.1 BC069328.1 BC069505.1 BC070043.1

BC104983.1 BC104985.1

8 DOTS entries:

DT.101964165 DT.85105318 DT.100773528 DT.100773526 DT.102827679 DT.95266059 DT.91842407 DT.95323641

24/110 AceView cDNA sequences (see all 110):

BQ064116 BM564479 AI675112 BU684928 AW338544 NM_033503 AY222040 AY222041

AW138086 AI869040 NM_001003940 NM_001003942 AI269493 BQ052769 BQ052207 AY029254

NM_001003943 AA261805 CB108463 BQ054664 BQ066091 CA428178 AW204740 BQ063844

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BMF (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:									-		-		-		-		-
SP2:					-				-		-		-		-		-						-		-
SP3:									-		-						-
SP4:									-		-		-		-		-						-		-
SP5:											-		-		-		-

ECgene alternative splicing isoforms for BMF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BMF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATATGTGTG

About this image

BMF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Stylopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Zeugopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BMF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BMF

SOURCE GeneReport for Unigene cluster: Hs.591104

UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9

Tissue specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in

B-CLL and normal B-cells

SABiosciences Expression via Pathway-Focused PCR Arrays including BMF:

Necrosis in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Cell Death PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMF Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BMF gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bmf^{1 , 5}	BCL2 modifying factor^{1, 5}	85.43(n)¹ 87.98(a)¹		2 (59.40 cM)⁵ 171543¹ NM_138313.3¹ NP_612186.2¹ 118528757⁵
chicken (Gallus gallus)	Aves	BMF¹	Bcl2 modifying factor	68.58(n) 67.82(a)		769140 NM_001113292.1 NP_001106763.1
lizard (Anolis carolinensis)	Reptilia	BMF⁶	--	59(a)	1 ↔ 1	GL343264.1(1556308-1577623)

ENSEMBL Gene Tree for BMF (if available)
TreeFam Gene Tree for BMF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76985763^1,2	F,	--	40379608(+)	`AAGAAA/CTGCAA`	4	--	ds500¹		1		WA	118
rs187798489^1,2		--	40379692(+)	`GTGCGA/GGAGGG`	4	--	ds500¹		0	--	--	--	--
rs116344246^1,2		--	40379734(+)	`AGTGGC/GAGACA`	4	--	ds500¹		1		WA	118
rs191050202^1,2		--	40379776(+)	`AAGGCA/CGGCAC`	4	--	ds500¹		0	--	--	--	--
rs113564972^1,2		--	40379787(+)	`AGTCGT/GATTTC`	4	--	ds500¹		2		CSA WA	120
rs139472585^1,2	C,	--	40379800(+)	`ACGTGG/TAAGAA`	4	--	ds500¹		0	--	--	--	--
rs150013819^1,2	C,	--	40379801(+)	`CGTGGA/TAGAAC`	4	--	ds500¹		0	--	--	--	--
rs145234357^1,2		--	40379856(+)	`TGGAGA/GAGGAG`	4	--	ds500¹		0	--	--	--	--
rs148778732^1,2		--	40379868(+)	`GAACCA/GGGTCC`	4	--	ds500¹		0	--	--	--	--
rs540765^1,2	C,F,A,H,	--	40379877(-)	`GCAGGC/TTTTGG`	4	--	ds500¹		11		NA WA CSA EA	372

HapMap Linkage Disequilibrium report for BMF (40380091 - 40401093 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BMF: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMF

DNA2.0 Custom Variant and Variant Library Synthesis for BMF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BMF for disorders           About GeneDecksing

OMIM gene information: 606266    OMIM disorders: --

15 diseases for BMF:    About MalaCards

aortic valve stenosis laryngeal squamous cell carcinoma squamous cell carcinoma transitional cell carcinoma

chronic lymphocytic leukemia intrahepatic cholangiocarcinoma lymphocytic leukemia ptosis

laryngitis cholangiocarcinoma hepatocellular carcinoma carcinoma

leukemia myeloma hypoxia

Human Genome Epidemiology (HuGE) Navigator: BMF (6 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BMF gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with BMF)

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. (PubMed id 11546872)^{1, 2, 3, 9} Puthalakath H.... Strasser A. (2001)
Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. (PubMed id 14574334)^{1, 2, 9} Morales A.A....Osorio L.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)^{1, 2} Hattori A.... Ohara O. (2000)
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PubMed id 14561217)^{1, 9} Day C.L....Hinds M.G. (2004)
Bim and Bmf in tissue homeostasis and malignant disea se. (PubMed id 19641506)^{1, 9} PiA+on J.D....Villunger A. (2008)
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. (PubMed id 12591950)^{1, 9} Lei K. and Davis R.J. (2003)
Common variants near TARDBP and EGR2 are associated wi th susceptibility to Ewing sarcoma. (PubMed id 22327514)¹ Postel-Vinay S....Delattre O. (2012)
Eight common genetic variants associated with serum D HEAS levels suggest a key role in ageing mechanisms. (PubMed id 21533175)¹ Zhai G....Wallaschofski H. (2011)
BCL-2 modifying factor (BMF) is a central regulator o f anoikis in human intestinal epithelial cells. (PubMed id 21673109)¹ Hausmann M....Rogler G. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90427	HGNC: 24132	AceView: BMF	Ensembl:ENSG00000104081	euGenes: HUgn90427
ECgene: BMF	H-InvDB: BMF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BMF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BMF	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BMF gene
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Patent Information for BMF gene:
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