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BMF Gene

protein-coding   GIFtS: 59
GCID: GC15M040380

Bcl2 Modifying Factor

  Search for BMF
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bcl2 Modifying Factor1 2
Bcl-2-Modifying Factor2

External Ids:    HGNC: 241321   Entrez Gene: 904272   Ensembl: ENSG000001040817   OMIM: 6062665   UniProtKB: Q96LC93   

Export aliases for BMF gene to outside databases

Previous GC identifers: GC15M035747 GC15M033275 GC15M037959 GC15M038096 GC15M038167 GC15M017223


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMF Gene:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or
homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular
activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins
and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its
association with dynein light chain 2, which may be important for sensing intracellular damage and triggering
apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for BMF Gene:
BMF (Bcl2 modifying factor) is a protein-coding gene.

UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9
Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator

Gene Wiki entry for BMF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMF gene promoter:
         E2F-3a   E2F-4   E2F-1   E2F   IRF-7A   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BMF promoter sequence
   Search Chromatin IP Primers for BMF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

BMF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMF gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M040380:  view genomic region     (about GC identifiers)

Start:
40,380,091 bp from pter      End:
40,401,093 bp from pter
Size:
21,003 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9 (See protein sequence)
Recommended Name: Bcl-2-modifying factor  
Size: 184 amino acids; 20508 Da
Subunit: Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin
motor complex through its binding to DLC2 (By similarity)
Sequence caution: Sequence=AAH60783.1; Type=Erroneous initiation; Sequence=BAB15762.1; Type=Erroneous initiation;
Secondary accessions: Q2M396 Q6NT30 Q6NT56 Q6P9F6 Q7Z7D4 Q7Z7D5 Q9H7K7
Alternative splicing: 3 isoforms:  Q96LC9-1   Q96LC9-2   Q96LC9-3   

Explore the universe of human proteins at neXtProt for BMF: NX_Q96LC9

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (4 alternative transcripts): 
    NP_001003940.1  NP_001003942.1  NP_277038.1  NP_001003943.1  

    ENSEMBL proteins: 
     ENSP00000346697   ENSP00000380703   ENSP00000453892   ENSP00000453522   ENSP00000453913  
     ENSP00000396511   ENSP00000453919   ENSP00000454142   ENSP00000452660   ENSP00000220446  
    Reactome Protein details: Q96LC9

    BMF Human Recombinant Protein Products:

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    Novus Biologicals BMF Proteins
    Novus Biologicals BMF Lysate
    Sino Biological Recombinant Protein for BMF
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BMF
    Cloud-Clone Corp. Proteins for BMF

     
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    BMF Antibody Products:

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    LSBio Antibodies in human, mouse, rat for BMF

    BMF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMF
    Cloud-Clone Corp. CLIAs for BMF
    Search eBioscience for ELISAs for BMF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028192 BMF

    Graphical View of Domain Structure for InterPro Entry Q96LC9

    ProtoNet protein and cluster: Q96LC9

    UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9
    Similarity: Belongs to the Bcl-2 family


    Find genes that share domains with BMF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMF_HUMAN, Q96LC9
    Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11546872
         
    Find genes that share ontologies with BMF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BMF:
     Increased HPV18 LCR reporter a 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Bmf):
     cellular  growth/size/body  hematopoietic system  immune system  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  normal  reproductive system  tumorigenesis 

    Find genes that share phenotypes with BMF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BMF: Bmftm1.1Anvi Bmftm1Rjd Bmftm4.1Rjd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMF

    miRNA
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    hsa-mir-125b-5p (MIRT003394), hsa-mir-221-3p (MIRT000141)

    Block miRNA regulation of human, mouse, rat BMF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMF (see all 80):
    hsa-miR-1914* hsa-miR-10b* hsa-miR-761 hsa-miR-374b* hsa-miR-4324 hsa-miR-1266 hsa-miR-4306 hsa-miR-1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BMF

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): BMF (NM_001003940)
    Sino Biological Human cDNA Clone for BMF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMF
    Addgene plasmids for BMF 

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    eBioscience FlowRNA Probe Sets ( VA4-12667 VA6-11766) for BMF 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    mitochondrion4
    plasma membrane4
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm ----
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with BMF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMF About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members0.00
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    2Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BMF and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    4Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    5CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38


    Find genes that share SuperPaths with BMF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BMF
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for BMF
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    2 BioSystems Pathways for BMF
        Apoptosis Modulation and Signaling
    Androgen receptor signaling pathway


    2 Reactome Pathways for BMF
        Activation of BMF and translocation to mitochondria
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


    1 Kegg Pathway  (Kegg details for BMF):
        MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMF: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BMF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for BMF (Q96LC93 ENSP000003466974) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2L2Q928433, ENSP000002504054I2D: score=5 STRING: ENSP00000250405
    BCL2P104153, ENSP000003296234I2D: score=5 STRING: ENSP00000329623
    BCL2L2-PABPN1Q928433I2D: score=5 
    BCL2L1Q078173, ENSP000003025644I2D: score=3 STRING: ENSP00000302564
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0032464positive regulation of protein homooligomerization ISS--
    GO:0043276anoikis IDA11546872
    GO:0090200positive regulation of release of cytochrome c from mitochondria ISS--
    GO:0097193intrinsic apoptotic signaling pathway TAS--

    Find genes that share ontologies with BMF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BMF gene (4 alternative transcripts): 
    NM_001003940.1  NM_001003942.1  NM_033503.3  NM_001003943.2  

    Unigene Cluster for BMF:

    Bcl2 modifying factor
    Hs.591104  [show with all ESTs]
    Unigene Representative Sequence: NM_001003940
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354670(uc001zkt.3 uc001zku.3 uc001zkw.3) ENST00000397573(uc001zkv.3)
    ENST00000561360 ENST00000561282 ENST00000558774 ENST00000431415 ENST00000559701
    ENST00000557870 ENST00000560430 ENST00000558057 ENST00000220446
    miRNA
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    Block miRNA regulation of human, mouse, rat BMF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMF (see all 80):
    hsa-miR-1914* hsa-miR-10b* hsa-miR-761 hsa-miR-374b* hsa-miR-4324 hsa-miR-1266 hsa-miR-4306 hsa-miR-1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for BMF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BMF (NM_001003940)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMF
    Addgene plasmids for BMF 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMF
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK024472.1 AY029254.1 AY222040.1 AY222041.1 BC060783.1 BC069328.1 BC069505.1 BC070043.1 
    BC104983.1 BC104985.1 

    8 DOTS entries:

    DT.101964165  DT.85105318  DT.100773528  DT.100773526  DT.102827679  DT.95266059  DT.91842407  DT.95323641 

    Selected AceView cDNA sequences (see all 110):

    AW138086 AY222041 AI675112 NM_001003940 AA261805 NM_001003942 CA428178 AI269493 
    NM_001003943 BQ052207 NM_033503 AY222040 AW338544 BQ066091 AY029254 AI869040 
    BQ064116 BQ054664 BQ052769 BU684928 BM564479 CB108463 BE349986 BE797144 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BMF (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -     -     -     -     -                                                         
    SP2:              -           -     -     -     -     -                 -     -                                 
    SP3:                          -     -                 -                                                         
    SP4:                          -     -     -     -     -                 -     -                                 
    SP5:                                -     -     -     -                                                         


    ECgene alternative splicing isoforms for BMF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATGTGTG
    BMF Expression
    About this image


    BMF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Prechondrocytes Autopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Prechondrocytes Autopod Epiphyseal End
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Lymph (Hematopoietic System)
    BMF Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.591104

    UniProtKB/Swiss-Prot: BMF_HUMAN, Q96LC9
    Tissue specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly
    expressed in B-CLL and normal B-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMF: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BMF gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmf1 , 5 BCL2 modifying factor1, 5 85.43(n)1
    87.98(a)1
      2 (59.40 cM)5
    1715431  NM_138313.31  NP_612186.21 
     1185287575 
    chicken
    (Gallus gallus)
    Aves BMF1 Bcl2 modifying factor 68.58(n)
    67.82(a)
      769140  NM_001113292.1  NP_001106763.1 
    lizard
    (Anolis carolinensis)
    Reptilia BMF6
    Bcl2 modifying factor
    51(a)
    1 ↔ 1
    GL343264.1(1546645-1608195)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bmf1 Bcl2 modifying factor 62.62(n)
    54.91(a)
      100495515  XM_004917290.1  XP_004917347.1 


    ENSEMBL Gene Tree for BMF (if available)
    TreeFam Gene Tree for BMF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMF (see all 480)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769857631,2
    C,F--20447157(+) AAGAAA/CTGCAA 2 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1877984891,2
    --20447241(+) GTGCGA/GGAGGG 2 -- ds50010--------
    rs1163442461,2
    F--20447283(+) AGTGGC/GAGACA 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1910502021,2
    --20447325(+) AAGGCA/CGGCAC 2 -- ds50010--------
    rs1135649721,2
    C,F--20447336(+) AGTCGT/GATTTC 2 -- ds50012Minor allele frequency- G:0.05CSA WA 120
    rs1394725851,2
    C--20447349(+) ACGTGG/TAAGAA 2 -- ds50010--------
    rs1500138191,2
    C--20447350(+) CGTGGA/TAGAAC 2 -- ds50010--------
    rs1452343571,2
    --20447405(+) TGGAGA/GAGGAG 2 -- ds50010--------
    rs1487787321,2
    --20447417(+) GAACCA/GGGTCC 2 -- ds50010--------
    rs5407651,2
    C,F,A,H--20447426(-) GCAGGC/TTTTGG 2 -- ds500111Minor allele frequency- T:0.33NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for BMF (40380091 - 40401093 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BMF: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMF
    DNA2.0 Custom Variant and Variant Library Synthesis for BMF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606266    OMIM disorders: --


    Find genes that share disorders with BMF           About GenesLikeMe

    Genetic Association Database (GAD): BMF
    Human Genome Epidemiology (HuGE) Navigator: BMF (6 documents)

    Export disorders for BMF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMF gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with BMF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. (PubMed id 11546872)1, 2, 3, 9 Puthalakath H.... Strasser A. (Science 2001)
    2. Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. (PubMed id 14574334)1, 2, 9 Morales A.A....Osorio L.M. (Leukemia 2004)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    6. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PubMed id 14561217)1, 9 Day C.L....Hinds M.G. (Biochem. J. 2004)
    7. Bim and Bmf in tissue homeostasis and malignant disease. (PubMed id 19641506)1, 9 PiA+on J.D....Villunger A. (Oncogene 2008)
    8. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. (PubMed id 12591950)1, 9 Lei K. and Davis R.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. (PubMed id 22327514)1 Postel-Vinay S....Delattre O. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90427 HGNC: 24132 AceView: BMF Ensembl:ENSG00000104081 euGenes: HUgn90427
    ECgene: BMF Kegg: 90427 H-InvDB: BMF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BMF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BMF gene:
    Search GeneIP for patents involving BMF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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