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Aliases for BMF Gene

Aliases for BMF Gene

  • Bcl2 Modifying Factor 2 3

External Ids for BMF Gene

Previous GeneCards Identifiers for BMF Gene

  • GC15M035747
  • GC15M033275
  • GC15M037959
  • GC15M038096
  • GC15M038167
  • GC15M040380
  • GC15M017223

Summaries for BMF Gene

Entrez Gene Summary for BMF Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMF Gene

BMF (Bcl2 Modifying Factor) is a Protein Coding gene. Among its related pathways are MicroRNAs in cancer and Androgen receptor signaling pathway.

UniProtKB/Swiss-Prot for BMF Gene

  • May play a role in apoptosis. Isoform 1 seems to be the main initiator

Gene Wiki entry for BMF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMF Gene

Genomics for BMF Gene

Regulatory Elements for BMF Gene

Genomic Location for BMF Gene

Start:
40,087,890 bp from pter
End:
40,108,892 bp from pter
Size:
21,003 bases
Orientation:
Minus strand

Genomic View for BMF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMF Gene

Proteins for BMF Gene

  • Protein details for BMF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LC9-BMF_HUMAN
    Recommended name:
    Bcl-2-modifying factor
    Protein Accession:
    Q96LC9
    Secondary Accessions:
    • Q2M396
    • Q6NT30
    • Q6NT56
    • Q6P9F6
    • Q7Z7D4
    • Q7Z7D5
    • Q9H7K7

    Protein attributes for BMF Gene

    Size:
    184 amino acids
    Molecular mass:
    20508 Da
    Quaternary structure:
    • Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 (By similarity).
    SequenceCaution:
    • Sequence=AAH60783.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BMF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BMF Gene

Proteomics data for BMF Gene at MOPED

Post-translational modifications for BMF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BMF Gene

Domains for BMF Gene

Protein Domains for BMF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BMF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LC9

UniProtKB/Swiss-Prot:

BMF_HUMAN :
  • Q96LC9
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BMF: view

No data available for Gene Families for BMF Gene

Function for BMF Gene

Molecular function for BMF Gene

UniProtKB/Swiss-Prot Function: May play a role in apoptosis. Isoform 1 seems to be the main initiator

Gene Ontology (GO) - Molecular Function for BMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11546872
genes like me logo Genes that share ontologies with BMF: view
genes like me logo Genes that share phenotypes with BMF: view

Animal Models for BMF Gene

MGI Knock Outs for BMF:

miRNA for BMF Gene

miRTarBase miRNAs that target BMF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BMF Gene

Localization for BMF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMF Gene COMPARTMENTS Subcellular localization image for BMF gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 4
plasma membrane 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for BMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with BMF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BMF Gene

Pathways for BMF Gene

genes like me logo Genes that share pathways with BMF: view

Gene Ontology (GO) - Biological Process for BMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0012501 programmed cell death TAS --
GO:0032464 positive regulation of protein homooligomerization ISS --
GO:0043276 anoikis IDA 11546872
GO:0090200 positive regulation of release of cytochrome c from mitochondria ISS --
genes like me logo Genes that share ontologies with BMF: view

Transcripts for BMF Gene

Unigene Clusters for BMF Gene

Bcl2 modifying factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMF Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - -
SP6: -
SP7:
SP8: -

Relevant External Links for BMF Gene

GeneLoc Exon Structure for
BMF
ECgene alternative splicing isoforms for
BMF

Expression for BMF Gene

mRNA expression in normal human tissues for BMF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMF Gene

SOURCE GeneReport for Unigene cluster for BMF Gene Hs.591104

mRNA Expression by UniProt/SwissProt for BMF Gene

Q96LC9-BMF_HUMAN
Tissue specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.
genes like me logo Genes that share expressions with BMF: view

No data available for mRNA differential expression in normal tissues for BMF Gene

Orthologs for BMF Gene

This gene was present in the common ancestor of chordates.

Orthologs for BMF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMF 35
  • 99.64 (n)
  • 99.46 (a)
BMF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BMF 35
  • 91.85 (n)
  • 91.85 (a)
BMF 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMF 35
  • 91.3 (n)
  • 94.02 (a)
BMF 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmf 35
  • 85.43 (n)
  • 87.98 (a)
Bmf 16
Bmf 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BMF 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmf 35
  • 85.61 (n)
  • 87.98 (a)
chicken
(Gallus gallus)
Aves BMF 35
  • 68.58 (n)
  • 67.82 (a)
BMF 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMF 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bmf 35
  • 62.62 (n)
  • 54.91 (a)
Species with no ortholog for BMF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BMF Gene

ENSEMBL:
Gene Tree for BMF (if available)
TreeFam:
Gene Tree for BMF (if available)

Paralogs for BMF Gene

No data available for Paralogs for BMF Gene

Variants for BMF Gene

Sequence variations from dbSNP and Humsavar for BMF Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs8116 -- 40,088,006(-) AAAAA(A/T)CTGTA utr-variant-3-prime
rs484943 -- 40,106,553(-) TCTGT(A/G)TGTGT intron-variant, upstream-variant-2KB
rs495654 -- 40,102,529(-) CCCTG(C/G)CACAG intron-variant
rs500804 -- 40,101,061(-) TCATT(C/T)CCCAT intron-variant
rs511338 -- 40,097,081(-) CTGCT(C/G)TCAAT intron-variant

Relevant External Links for BMF Gene

HapMap Linkage Disequilibrium report
BMF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BMF Gene

Disorders for BMF Gene

Relevant External Links for BMF

Genetic Association Database (GAD)
BMF
Human Genome Epidemiology (HuGE) Navigator
BMF
genes like me logo Genes that share disorders with BMF: view

No data available for UniProtKB/Swiss-Prot for BMF Gene

Publications for BMF Gene

  1. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. (PMID: 11546872) Puthalakath H. … Strasser A. (Science 2001) 2 3 4 23
  2. Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. (PMID: 14574334) Morales A.A. … Osorio L.M. (Leukemia 2004) 3 4 23
  3. Bim and Bmf in tissue homeostasis and malignant disease. (PMID: 19641506) PiA+on J.D. … Villunger A. (Oncogene 2008) 3 23
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 48

Products for BMF Gene

  • Addgene plasmids for BMF

Sources for BMF Gene

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