External Ids for BMF Gene
Previous GeneCards Identifiers for BMF Gene
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for BMF Gene
BMF (Bcl2 Modifying Factor) is a Protein Coding gene. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Regulation of activated PAK-2p34 by proteasome mediated degradation.
UniProtKB/Swiss-Prot for BMF Gene
May play a role in apoptosis. Isoform 1 seems to be the main initiator.