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Aliases for BLVRB Gene

Aliases for BLVRB Gene

  • Biliverdin Reductase B 2 3 4
  • FLR 3 4 6
  • Biliverdin Reductase B (Flavin Reductase (NADPH)) 2 3
  • Biliverdin-IX Beta-Reductase 3 4
  • Green Heme-Binding Protein 3 4
  • NADPH-Dependent Diaphorase 3 4
  • NADPH-Flavin Reductase 3 4
  • BVR-B 3 4
  • GHBP 3 4
  • BVRB 3 6
  • FR 3 4
  • Short Chain Dehydrogenase/Reductase Family 43U, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 43U 2
  • Epididymis Secretory Protein Li 10 3
  • (Flavin Reductase (NADPH)) 2
  • Flavin Reductase (NADPH) 3
  • Flavin Reductase 2
  • EC 1.5.1.30 4
  • EC 1.3.1.24 4
  • Member 1 2
  • HEL-S-10 3
  • SDR43U1 3

External Ids for BLVRB Gene

Previous HGNC Symbols for BLVRB Gene

  • FLR

Previous GeneCards Identifiers for BLVRB Gene

  • GC19M041593
  • GC19M041345
  • GC19M045629
  • GC19M045645
  • GC19M040953
  • GC19M037389

Summaries for BLVRB Gene

Entrez Gene Summary for BLVRB Gene

  • The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

GeneCards Summary for BLVRB Gene

BLVRB (Biliverdin Reductase B) is a Protein Coding gene. Diseases associated with BLVRB include cauda equina syndrome and impotence. Among its related pathways are Metabolism and Riboflavin metabolism. GO annotations related to this gene include biliverdin reductase activity and riboflavin reductase (NADPH) activity.

UniProtKB/Swiss-Prot for BLVRB Gene

  • Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLVRB Gene

Genomics for BLVRB Gene

Regulatory Elements for BLVRB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BLVRB Gene

Start:
40,447,784 bp from pter
End:
40,465,840 bp from pter
Size:
18,057 bases
Orientation:
Minus strand

Genomic View for BLVRB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BLVRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLVRB Gene

Proteins for BLVRB Gene

  • Protein details for BLVRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30043-BLVRB_HUMAN
    Recommended name:
    Flavin reductase (NADPH)
    Protein Accession:
    P30043
    Secondary Accessions:
    • A6NKD8
    • B2R5C6
    • P32078
    • P53005
    • Q32LZ2

    Protein attributes for BLVRB Gene

    Size:
    206 amino acids
    Molecular mass:
    22119 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for BLVRB Gene

neXtProt entry for BLVRB Gene

Proteomics data for BLVRB Gene at MOPED

Post-translational modifications for BLVRB Gene

  • Ubiquitination at Lys178
  • Modification sites at PhosphoSitePlus

Other Protein References for BLVRB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for BLVRB (Biliverdin Reductase B/BLVRB)

No data available for DME Specific Peptides for BLVRB Gene

Domains for BLVRB Gene

Gene Families for BLVRB Gene

HGNC:
  • SDRA :Short chain dehydrogenase/reductase superfamily / Atypical members

Protein Domains for BLVRB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BLVRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLVRB: view

No data available for UniProtKB/Swiss-Prot for BLVRB Gene

Function for BLVRB Gene

Molecular function for BLVRB Gene

GENATLAS Biochemistry:
biliverdin reductase IX beta (21kDa),expressed in fetal liver
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=36 uM for NADP {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=5.6 mM for NADH {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=0.3 uM for biliverdin IX-beta {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=52 uM for FMN {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=125 uM for FAD {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=53 uM for riboflavin {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092};
UniProtKB/Swiss-Prot CatalyticActivity:
Reduced riboflavin + NADP(+) = riboflavin + NADPH
UniProtKB/Swiss-Prot CatalyticActivity:
Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H
UniProtKB/Swiss-Prot EnzymeRegulation:
Mesobiliverdin acts as competitve inhibitor for flavin reduction, indicating that flavin and tetrapyrrole substrates compete for the same site.
UniProtKB/Swiss-Prot Function:
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.

Enzyme Numbers (IUBMB) for BLVRB Gene

Gene Ontology (GO) - Molecular Function for BLVRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity --
GO:0004074 biliverdin reductase activity IDA 7929092
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0042602 riboflavin reductase (NADPH) activity IDA 11224564
genes like me logo Genes that share ontologies with BLVRB: view

Animal Model Products

miRNA for BLVRB Gene

miRTarBase miRNAs that target BLVRB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BLVRB

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BLVRB Gene

Localization for BLVRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLVRB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BLVRB Gene COMPARTMENTS Subcellular localization image for BLVRB gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BLVRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with BLVRB: view

Pathways for BLVRB Gene

genes like me logo Genes that share pathways with BLVRB: view

Pathways by source for BLVRB Gene

1 BioSystems pathway for BLVRB Gene
3 Reactome pathways for BLVRB Gene
1 PharmGKB pathway for BLVRB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BLVRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process --
GO:0006778 porphyrin-containing compound metabolic process TAS --
GO:0042167 heme catabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with BLVRB: view

Compounds for BLVRB Gene

(11) HMDB Compounds for BLVRB Gene

Compound Synonyms Cas Number PubMed IDs
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
22594-61-2
Bilirubin
  • (4Z,15Z)-Bilirubin IXa
635-65-4
Biliverdin
  • 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone
114-25-0
Heme
  • (protoporphyrinato)iron
14875-96-8
Iron
  • Armco iron
7439-89-6

(7) Drugbank Compounds for BLVRB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Monophosphoadenosine 5'-Diphosphoribose
target
7,8-dimethylalloxazine
  • 6,7-Dimethylalloxazine
1086-80-2 target
Biliverdine Ix Alpha
114-25-0 target
Mesobiliverdin Iv Alpha
target
NADH
  • beta-DPNH
606-68-8 target

(62) Novoseek inferred chemical compound relationships for BLVRB Gene

Compound -log(P) Hits PubMed IDs
nadph 88.3 263
nitric oxide 84.9 136
flavin 72.7 44
mesobiliverdin 72.6 2
biliverdin 62.2 16

(1) PharmGKB related drug/compound annotations for BLVRB Gene

Drug/compound Annotation
methylene blue
genes like me logo Genes that share compounds with BLVRB: view

Transcripts for BLVRB Gene

mRNA/cDNA for BLVRB Gene

Unigene Clusters for BLVRB Gene

Biliverdin reductase B (flavin reductase (NADPH)):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BLVRB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLVRB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for BLVRB Gene

GeneLoc Exon Structure for
BLVRB
ECgene alternative splicing isoforms for
BLVRB

Expression for BLVRB Gene

mRNA expression in normal human tissues for BLVRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BLVRB Gene

This gene is overexpressed in Whole Blood (7.4).

Protein differential expression in normal tissues for BLVRB Gene

This gene is overexpressed in Spleen (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BLVRB Gene

SOURCE GeneReport for Unigene cluster for BLVRB Gene Hs.515785

mRNA Expression by UniProt/SwissProt for BLVRB Gene

P30043-BLVRB_HUMAN
Tissue specificity: Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.
genes like me logo Genes that share expressions with BLVRB: view

Expression partners for BLVRB Gene

In Situ Assay Products

Orthologs for BLVRB Gene

This gene was present in the common ancestor of animals.

Orthologs for BLVRB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BLVRB 35
  • 90.13 (n)
  • 91.26 (a)
BLVRB 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BLVRB 35
  • 91.06 (n)
  • 93.66 (a)
BLVRB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Blvrb 35
  • 89.27 (n)
  • 93.66 (a)
Blvrb 16
Blvrb 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BLVRB 35
  • 96.97 (n)
  • 95.72 (a)
BLVRB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Blvrb 35
  • 87.8 (n)
  • 94.15 (a)
oppossum
(Monodelphis domestica)
Mammalia BLVRB 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia BLVRB 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia blvrb 35
  • 63.3 (n)
  • 64.04 (a)
Str.3936 35
zebrafish
(Danio rerio)
Actinopterygii blvrb 35
blvrb 35
  • 63.18 (n)
  • 62.83 (a)
blvrb 36
  • 62 (a)
OneToMany
BLVRB (2 of 2) 36
  • 50 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10073 35
fruit fly
(Drosophila melanogaster)
Insecta CG9471 37
  • 38 (a)
CG9471 35
  • 48.77 (n)
  • 38.95 (a)
CG9471 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001321 35
  • 54.64 (n)
  • 43.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for BLVRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BLVRB Gene

ENSEMBL:
Gene Tree for BLVRB (if available)
TreeFam:
Gene Tree for BLVRB (if available)

Paralogs for BLVRB Gene

Pseudogenes.org Pseudogenes for BLVRB Gene

genes like me logo Genes that share paralogs with BLVRB: view

No data available for Paralogs for BLVRB Gene

Variants for BLVRB Gene

Sequence variations from dbSNP and Humsavar for BLVRB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10281 -- 40,447,864(-) AGGGT(A/G)GCATT utr-variant-3-prime
rs268692 -- 40,457,390(+) AATTT(A/G)TGTCA intron-variant
rs268693 -- 40,457,233(-) AAGCT(C/T)TGAAA intron-variant
rs268694 -- 40,456,475(-) ATATT(A/G)AAGTC intron-variant
rs268695 -- 40,455,079(-) gcttg(A/C)gtcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BLVRB Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294
nsv911709 CNV Loss 21882294
esv2658680 CNV Deletion 23128226
dgv3868n71 CNV Loss 21882294
nsv911711 CNV Loss 21882294

Relevant External Links for BLVRB Gene

HapMap Linkage Disequilibrium report
BLVRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLVRB Gene

Disorders for BLVRB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BLVRB Gene in MalaCards »

(6) Diseases for BLVRB Gene including...

(1) University of Copenhagen DISEASES for BLVRB Gene

(27) Novoseek inferred disease relationships for BLVRB Gene

Disease -log(P) Hits PubMed IDs
hirschsprung disease 68.3 11
motility disorder 52.2 1
huntington disease 51.2 11
pyloric stenosis 46.7 3
achalasia 34.8 7
genes like me logo Genes that share disorders with BLVRB: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for BLVRB Gene

Publications for BLVRB Gene

  1. Molecular cloning and expression of human liver biliverdin-IXbeta reductase. (PMID: 8799475) Komuro A. … Tomita M. (Biol. Pharm. Bull. 1996) 3 4 23
  2. Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. (PMID: 11224564) Pereira P.J. … Coll M. (Nat. Struct. Biol. 2001) 3 4 23
  3. Mapping of the newly identified biliverdin-IX beta reductase gene (BLVRB) to human chromosome 19q13.13-->q13.2 by fluorescence in situ hybridization. (PMID: 7656592) Saito F. … Nakajima H. (Cytogenet. Cell Genet. 1995) 2 3 23
  4. Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization. (PMID: 7929092) Yamaguchi T. … Nakajima H. (J. Biol. Chem. 1994) 3 4 23
  5. Complete amino acid sequence of biliverdin-IX beta reductase from human liver. (PMID: 8280170) Yamaguchi T. … Nakajima H. (Biochem. Biophys. Res. Commun. 1993) 3 4 23

Products for BLVRB Gene

Sources for BLVRB Gene

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