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Aliases for BLVRB Gene

Aliases for BLVRB Gene

  • Biliverdin Reductase B 2 3 4 5
  • Biliverdin Reductase B (Flavin Reductase (NADPH)) 2 3
  • Biliverdin-IX Beta-Reductase 3 4
  • Green Heme-Binding Protein 3 4
  • NADPH-Dependent Diaphorase 3 4
  • NADPH-Flavin Reductase 3 4
  • BVR-B 3 4
  • GHBP 3 4
  • FLR 3 4
  • FR 3 4
  • Short Chain Dehydrogenase/Reductase Family 43U, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 43U 2
  • Epididymis Secretory Protein Li 10 3
  • (Flavin Reductase (NADPH)) 2
  • Flavin Reductase 2
  • EC 1.5.1.30 4
  • EC 1.3.1.24 4
  • Member 1 2
  • HEL-S-10 3
  • SDR43U1 3
  • BVRB 3

External Ids for BLVRB Gene

Previous HGNC Symbols for BLVRB Gene

  • FLR

Previous GeneCards Identifiers for BLVRB Gene

  • GC19M041593
  • GC19M041345
  • GC19M045629
  • GC19M045645
  • GC19M040953
  • GC19M037389

Summaries for BLVRB Gene

Entrez Gene Summary for BLVRB Gene

  • The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

GeneCards Summary for BLVRB Gene

BLVRB (Biliverdin Reductase B) is a Protein Coding gene. Diseases associated with BLVRB include Pyloric Stenosis and Hirschsprung Disease 1. Among its related pathways are Porphyrin and chlorophyll metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and 3-beta-hydroxy-delta5-steroid dehydrogenase activity.

UniProtKB/Swiss-Prot for BLVRB Gene

  • Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLVRB Gene

Genomics for BLVRB Gene

Regulatory Elements for BLVRB Gene

Enhancers for BLVRB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BLVRB on UCSC Golden Path with GeneCards custom track

Promoters for BLVRB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BLVRB on UCSC Golden Path with GeneCards custom track

Genomic Location for BLVRB Gene

Chromosome:
19
Start:
40,447,784 bp from pter
End:
40,465,840 bp from pter
Size:
18,057 bases
Orientation:
Minus strand

Genomic View for BLVRB Gene

Genes around BLVRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLVRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLVRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLVRB Gene

Proteins for BLVRB Gene

  • Protein details for BLVRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30043-BLVRB_HUMAN
    Recommended name:
    Flavin reductase (NADPH)
    Protein Accession:
    P30043
    Secondary Accessions:
    • A6NKD8
    • B2R5C6
    • P32078
    • P53005
    • Q32LZ2

    Protein attributes for BLVRB Gene

    Size:
    206 amino acids
    Molecular mass:
    22119 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for BLVRB Gene

neXtProt entry for BLVRB Gene

Proteomics data for BLVRB Gene at MOPED

Post-translational modifications for BLVRB Gene

  • Ubiquitination at Lys 178
  • Modification sites at PhosphoSitePlus

Other Protein References for BLVRB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for BLVRB (Biliverdin Reductase B/BLVRB)

No data available for DME Specific Peptides for BLVRB Gene

Domains & Families for BLVRB Gene

Gene Families for BLVRB Gene

Protein Domains for BLVRB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BLVRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLVRB: view

No data available for UniProtKB/Swiss-Prot for BLVRB Gene

Function for BLVRB Gene

Molecular function for BLVRB Gene

GENATLAS Biochemistry:
biliverdin reductase IX beta (21kDa),expressed in fetal liver
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=36 uM for NADP {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=5.6 mM for NADH {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=0.3 uM for biliverdin IX-beta {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=52 uM for FMN {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=125 uM for FAD {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092}; KM=53 uM for riboflavin {ECO:0000269 PubMed:10620517, ECO:0000269 PubMed:7929092};
UniProtKB/Swiss-Prot CatalyticActivity:
Reduced riboflavin + NADP(+) = riboflavin + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H.
UniProtKB/Swiss-Prot EnzymeRegulation:
Mesobiliverdin acts as competitve inhibitor for flavin reduction, indicating that flavin and tetrapyrrole substrates compete for the same site.
UniProtKB/Swiss-Prot Function:
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.

Enzyme Numbers (IUBMB) for BLVRB Gene

genes like me logo Genes that share phenotypes with BLVRB: view

Animal Models for BLVRB Gene

MGI Knock Outs for BLVRB:

Animal Model Products

miRNA for BLVRB Gene

miRTarBase miRNAs that target BLVRB

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BLVRB Gene

Localization for BLVRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLVRB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BLVRB Gene COMPARTMENTS Subcellular localization image for BLVRB gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BLVRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BLVRB: view

Pathways & Interactions for BLVRB Gene

genes like me logo Genes that share pathways with BLVRB: view

Pathways by source for BLVRB Gene

1 BioSystems pathway for BLVRB Gene
3 Reactome pathways for BLVRB Gene
1 PharmGKB pathway for BLVRB Gene

Gene Ontology (GO) - Biological Process for BLVRB Gene

None

No data available for SIGNOR curated interactions for BLVRB Gene

Drugs & Compounds for BLVRB Gene

(37) Drugs for BLVRB Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riboflavin Approved Nutra Target, product of 150
FAD Approved Pharma 0
biliverdin Experimental Pharma Target 0
Flavin Mononucleotide Experimental Pharma Target 6
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(39) Additional Compounds for BLVRB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
  • 2-Keto-3-deoxy-D-glycero-D-galacto-nononate
  • 2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid
  • 2-Oxo-3-deoxy-D-glycero-galactononulosonate
  • 2-Oxo-3-deoxy-D-glycero-galactononulosonic acid
22594-61-2
FADH
  • 1,5-Dihydro-FAD
  • 1,5-Dihydro-P-5-ester with adenosine
  • 1,5-Dihydro-Riboflavin 5'-(trihydrogen diphosphate) P'->5'-ester with adenosine
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with 5,10-dihydro-7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)alloxazine
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'->5'-ester with 5,10-dihydro-7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)alloxazine
1910-41-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with BLVRB: view

Transcripts for BLVRB Gene

mRNA/cDNA for BLVRB Gene

Unigene Clusters for BLVRB Gene

Biliverdin reductase B (flavin reductase (NADPH)):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BLVRB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for BLVRB Gene

GeneLoc Exon Structure for
BLVRB
ECgene alternative splicing isoforms for
BLVRB

Expression for BLVRB Gene

mRNA expression in normal human tissues for BLVRB Gene

mRNA differential expression in normal tissues according to GTEx for BLVRB Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for BLVRB Gene

This gene is overexpressed in Spleen (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BLVRB Gene



SOURCE GeneReport for Unigene cluster for BLVRB Gene Hs.515785

mRNA Expression by UniProt/SwissProt for BLVRB Gene

P30043-BLVRB_HUMAN
Tissue specificity: Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.
genes like me logo Genes that share expression patterns with BLVRB: view

Protein tissue co-expression partners for BLVRB Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BLVRB Gene

Orthologs for BLVRB Gene

This gene was present in the common ancestor of animals.

Orthologs for BLVRB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BLVRB 35
  • 90.13 (n)
  • 91.26 (a)
BLVRB 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BLVRB 35
  • 91.06 (n)
  • 93.66 (a)
BLVRB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Blvrb 35
  • 89.27 (n)
  • 93.66 (a)
Blvrb 16
Blvrb 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BLVRB 35
  • 96.97 (n)
  • 95.72 (a)
BLVRB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Blvrb 35
  • 87.8 (n)
  • 94.15 (a)
oppossum
(Monodelphis domestica)
Mammalia BLVRB 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia BLVRB 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia blvrb 35
  • 63.3 (n)
  • 64.04 (a)
Str.3936 35
zebrafish
(Danio rerio)
Actinopterygii blvrb 35
blvrb 35
  • 63.18 (n)
  • 62.83 (a)
blvrb 36
  • 62 (a)
OneToMany
BLVRB (2 of 2) 36
  • 50 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10073 35
fruit fly
(Drosophila melanogaster)
Insecta CG9471 37
  • 38 (a)
CG9471 35
  • 48.77 (n)
  • 38.95 (a)
CG9471 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001321 35
  • 54.64 (n)
  • 43.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for BLVRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BLVRB Gene

ENSEMBL:
Gene Tree for BLVRB (if available)
TreeFam:
Gene Tree for BLVRB (if available)

Paralogs for BLVRB Gene

Pseudogenes.org Pseudogenes for BLVRB Gene

genes like me logo Genes that share paralogs with BLVRB: view

No data available for Paralogs for BLVRB Gene

Variants for BLVRB Gene

Sequence variations from dbSNP and Humsavar for BLVRB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11547746 - 40,458,488(-) GCCCC(A/G)GCCGG reference, missense
rs7257546 -- 40,452,895(+) caaaa(A/C)aaaaa intron-variant
rs12975787 -- 40,454,599(+) ggagt(G/T)cagtg intron-variant
rs7507689 -- 40,454,956(+) cctac(C/T)taagc intron-variant
rs12981511 -- 40,460,759(+) cctga(A/G)gttgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BLVRB Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294
nsv911709 CNV Loss 21882294
esv2658680 CNV Deletion 23128226
dgv3868n71 CNV Loss 21882294
nsv911711 CNV Loss 21882294

Variation tolerance for BLVRB Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BLVRB Gene

Disorders for BLVRB Gene

MalaCards: The human disease database

(2) MalaCards diseases for BLVRB Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
pyloric stenosis
hirschsprung disease 1
  • hirschsprung's disease
- elite association - COSMIC cancer census association via MalaCards
Search BLVRB in MalaCards View complete list of genes associated with diseases

Relevant External Links for BLVRB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BLVRB
genes like me logo Genes that share disorders with BLVRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BLVRB Gene

Publications for BLVRB Gene

  1. Evidence that biliverdin-IX beta reductase and flavin reductase are identical. (PMID: 8687377) Shalloe F. … Mantle T.J. (Biochem. J. 1996) 3 4 23 67
  2. Flavin-dependent halogenases involved in secondary metabolism in bacteria. (PMID: 16544142) van PAce K.H. … Patallo E.P. (Appl. Microbiol. Biotechnol. 2006) 23 25 26
  3. Mapping of the newly identified biliverdin-IX beta reductase gene (BLVRB) to human chromosome 19q13.13-->q13.2 by fluorescence in situ hybridization. (PMID: 7656592) Saito F. … Nakajima H. (Cytogenet. Cell Genet. 1995) 2 3 23
  4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  5. Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase. (PMID: 18241201) Smith L.J. … Mantle T.J. (Biochem. J. 2008) 3 23

Products for BLVRB Gene

Sources for BLVRB Gene

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