Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BLVRA Gene

protein-coding   GIFtS: 65
GCID: GC07P043798

Biliverdin Reductase A


(Previous symbol: BLVR)
  See BLVRA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Biliverdin Reductase A1 2     BVR A2 3
BLVR1 2 3     BVRA2
Biliverdin-IX Alpha-Reductase2 3     EC 1.3.1.243
BVR2 3     

External Ids:    HGNC: 10621   Entrez Gene: 6442   Ensembl: ENSG000001066057   OMIM: 1097505   UniProtKB: P530043   

Export aliases for BLVRA gene to outside databases

Previous GC identifers: GC07P043444 GC07P043539 GC07P043571 GC07P043764 GC07P043683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BLVRA Gene:
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the
conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated
with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. (provided by
RefSeq, Dec 2011)

GeneCards Summary for BLVRA Gene:
BLVRA (biliverdin reductase A) is a protein-coding gene. Diseases associated with BLVRA include hyperbiliverdinemia, and spontaneous pneumothorax. GO annotations related to this gene include biliverdin reductase activity.

UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
Function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the
concomitant oxidation of a NADH or NADPH cofactor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the BLVRA gene promoter:
         TBP   Max1   RFX1   Sox5   AML1a   Nkx2-2   Lmo2   E47   Hand1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBLVRA promoter sequence
   Search Chromatin IP Primers for BLVRA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BLVRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

BLVRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BLVRA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P043798:  view genomic region     (about GC identifiers)

Start:
43,798,272 bp from pter      End:
43,846,941 bp from pter
Size:
48,670 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 43,837,746-43,886,418     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004 (See protein sequence)
Recommended Name: Biliverdin reductase A precursor  
Size: 296 amino acids; 33428 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer
Miscellaneous: Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9)
and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems
1 PDB 3D structure from and Proteopedia for BLVRA:
2H63 (3D)    
Secondary accessions: A8K747 O95019 Q86UX0 Q96QL4 Q9BRW8

Explore the universe of human proteins at neXtProt for BLVRA: NX_P53004

Explore proteomics data for BLVRA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys219, Lys234, Lys253, Lys261, Lys269
  • Modification sites at PhosphoSitePlus

  • See BLVRA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000703.2  NP_001240752.1  

    ENSEMBL proteins: 
     ENSP00000265523   ENSP00000385757   ENSP00000412005  
    Reactome Protein details: P53004

    BLVRA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BLVRA (Biliverdin Reductase A/BLVRA)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BLVRA
    OriGene Protein Over-expression Lysate for BLVRA
    OriGene MassSpec for BLVRA
    OriGene Custom Protein Services for BLVRA
    GenScript Custom Purified and Recombinant Proteins Services for BLVRA
    Novus Biologicals BLVRA Proteins
    Novus Biologicals BLVRA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BLVRA
    Cloud-Clone Corp. Proteins for BLVRA

     
    Search eBioscience for Proteins for BLVRA 

     
    antibodies-online proteins for BLVRA (15 products) 

     
    antibodies-online peptides for BLVRA

    BLVRA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BLVRA
    Novus Biologicals BLVRA Antibodies
    Abcam antibodies for BLVRA
    Cloud-Clone Corp. Antibodies for BLVRA
    ThermoFisher Antibody for BLVRA
    LSBio Antibodies in human, mouse, rat for BLVRA
    antibodies-online antibodies for BLVRA (33 products) 

    BLVRA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BLVRA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BLVRA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BLVRA
    Cloud-Clone Corp. CLIAs for BLVRA
    Search eBioscience for ELISAs for BLVRA 
    antibodies-online kits for BLVRA (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR017094 Biliverdin_Rdtase_A
     IPR015249 Biliverdin_Rdtase_cat
     IPR000683 Oxidoreductase_N
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P53004

    ProtoNet protein and cluster: P53004

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
    Similarity: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily


    Find genes that share domains with BLVRA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIEA_HUMAN, P53004
    Function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the
    concomitant oxidation of a NADH or NADPH cofactor
    Catalytic activity: Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H

         Genatlas biochemistry entry for BLVRA:
    biliverdin reductase IX alpha,22kDa,expressed in adult liver

         Enzyme Number (IUBMB): EC 1.3.1.241

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004074biliverdin reductase activity IDA10858451
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with BLVRA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BLVRA:
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BLVRA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BLVRA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BLVRA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BLVRA

    miRNA
    Products:
        
    miRTarBase miRNAs that target BLVRA:
    hsa-mir-17-5p (MIRT050960)

    Block miRNA regulation of human, mouse, rat BLVRA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BLVRA
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BLVRA
    Predesigned siRNA for gene silencing in human, mouse, rat BLVRA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BLVRA

    Clone
    Products:
         
    OriGene clones in human, mouse for BLVRA (see all 6)
    OriGene ORF clones in mouse, rat for BLVRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BLVRA (NM_000712)
    Sino Biological Human cDNA Clone for BLVRA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BLVRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLVRA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BLVRA
    Browse ESI BIO Cell Lines and PureStem Progenitors for BLVRA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLVRA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BIEA_HUMAN, P53004: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with BLVRA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BLVRA About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of porphyrins
    Metabolism of porphyrins0.56
    Heme degradation0.00
    Porphyrin and chlorophyll metabolism0.56
    heme degradation0.00
    2Metabolism
    Metabolism0.38
    3IL-10 Pathway
    IL-10 Pathway


    Find genes that share SuperPaths with BLVRA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BLVRA
        IL-10 Pathway

    1 BioSystems Pathway for BLVRA
        heme degradation


    1 Reactome Pathway for BLVRA
        Heme degradation


    1 Kegg Pathway  (Kegg details for BLVRA):
        Porphyrin and chlorophyll metabolism

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
    Pathway: Porphyrin-containing compound metabolism; protoheme degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including BLVRA: 

              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BLVRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BLVRA (P530042, 3 ENSP000002655234) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG101Q9BSB43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    PRKCZQ055133I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006778porphyrin-containing compound metabolic process TAS--
    GO:0042167heme catabolic process TAS10858451
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process IDA10858451

    Find genes that share ontologies with BLVRA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BLVRA (BIEA)

    8 HMDB Compounds for BLVRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-4--
    Biliverdin1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone (see all 7)114-25-0--
    Formyl-CoAFormyl coenzyme A 13131-49-2--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 DrugBank Compounds for BLVRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17402939
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235

    Selected Novoseek inferred chemical compound relationships for BLVRA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliverdin 96 90 19614742 (5), 19509285 (4), 19690164 (3), 18276984 (2) (see all 35)
    bilirubin ixalpha 83.5 1 12196151 (1)
    uridine diphosphate 72.8 2 19238116 (1)
    phytochrome 53.9 7 9165746 (3), 10517855 (2)
    hydride 52.2 1 12196151 (1)
    haem 47.7 1 8631357 (1)
    nadph 46.2 3 12196151 (1), 15226268 (1), 8631357 (1)
    threonine 41.5 3 14988408 (1), 15870194 (1), 11278740 (1)
    nadh 35 1 8631357 (1)
    serine 27.5 9 15870194 (4), 14988408 (1), 11278740 (1)



    Find genes that share compounds with BLVRA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BLVRA gene (2 alternative transcripts): 
    NM_000712.3  NM_001253823.1  

    Unigene Cluster for BLVRA:

    Biliverdin reductase A
    Hs.488143  [show with all ESTs]
    Unigene Representative Sequence: BX647539
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265523(uc003tir.3) ENST00000402924(uc010kxv.3) ENST00000424330
    ENST00000453612 ENST00000486984
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BLVRA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BLVRA
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BLVRA
    Predesigned siRNA for gene silencing in human, mouse, rat BLVRA
    Clone
    Products:
         
    OriGene clones in human, mouse for BLVRA (see all 6)
    OriGene ORF clones in mouse, rat for BLVRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BLVRA (NM_000712)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BLVRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLVRA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BLVRA
    OriGene qSTAR qPCR primer pairs in human, mouse for BLVRA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BLVRA
      QuantiTect SYBR Green Assays in human, mouse, rat BLVRA
      QuantiFast Probe-based Assays in human, mouse, rat BLVRA

    Additional mRNA sequence: 

    AK291862.1 BC005902.1 BC008456.1 BX647539.1 U34877.1 X93086.1 

    8 DOTS entries:

    DT.447342  DT.100788322  DT.100788320  DT.75156165  DT.95373175  DT.121113103  DT.121113104  DT.86859543 

    Selected AceView cDNA sequences (see all 173):

    AI522038 CA418616 CA423398 AA506016 NM_000712 BM708417 H28171 BC008456 
    BM893943 BU196520 BQ680920 AA594489 C01830 BM710258 N21095 AA970668 
    N31107 BU689144 BU156742 BM563558 AA595133 AI478194 BQ130539 BM701812 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BLVRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGGGAAAC
    BLVRA Expression
    About this image

    BLVRA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BLVRA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.488143

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
    Tissue specificity: Liver

        Pathway & Disease-focused RT2 Profiler PCR Array including BLVRA: 
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BLVRA
    OriGene qSTAR qPCR primer pairs in human, mouse for BLVRA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BLVRA
    QuantiTect SYBR Green Assays in human, mouse, rat BLVRA
    QuantiFast Probe-based Assays in human, mouse, rat BLVRA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLVRA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for BLVRA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Blvra1 , 5 biliverdin reductase A1, 5 83.05(n)1
    83.85(a)1
      2 (61.76 cM)5
    1097781  NM_026678.41  NP_080954.41 
     1270706655 
    chicken
    (Gallus gallus)
    Aves BLVRA1 biliverdin reductase A 62.53(n)
    60.58(a)
      420776  XM_418872.3  XP_418872.3 
    lizard
    (Anolis carolinensis)
    Reptilia BLVRA6
    biliverdin reductase A
    57(a)
    1 ↔ 1
    6(50952171-51016356)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420134682   -- 75.51(n)    142013468 
    zebrafish
    (Danio rerio)
    Actinopterygii blvra1 biliverdin reductase A 58.02(n)
    55.93(a)
      767661  NM_001076601.1  NP_001070069.1 


    ENSEMBL Gene Tree for BLVRA (if available)
    TreeFam Gene Tree for BLVRA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BLVRA (see all 952)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180082001,2
    F--43771460(+) ATGGAG/AGGCCC 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1157875121,2
    C,F--43771477(+) CAGGCT/ATTCCC 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1869029421,2
    --43771494(+) CCTCTA/GGGTGT 2 -- us2k10--------
    rs102403881,2
    C,F,H--43771710(+) TTTCCG/AAGAAA 2 -- us2k16Minor allele frequency- A:0.00NS EA NA 598
    rs2019006371,2
    --43772399(+) TTGCC-/ATCGAG 2 -- us2k10--------
    rs1404801121,2
    --43772401(+) GCCATC/TGAGAT 2 -- us2k10--------
    rs795691851,2
    F--43772448(+) TGGATG/ATGTTG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs16375301,2
    C,F,H--43772576(+) TCTCTC/TTGCAC 2 -- us2k1 trp325Minor allele frequency- T:0.16NS EA NA WA CSA 2519
    rs172457781,2
    C,F--43772680(+) GAACGC/ATGCCT 2 -- us2k12Minor allele frequency- A:0.04NS WA 286
    rs172457851,2
    C,F--43772787(+) ATCAGG/AATCCC 2 -- us2k13Minor allele frequency- A:0.10NS WA NA 398

    HapMap Linkage Disequilibrium report for BLVRA (43798272 - 43846941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BLVRA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv464441CNV Loss19166990

    Human Gene Mutation Database (HGMD): BLVRA
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BLVRA
    DNA2.0 Custom Variant and Variant Library Synthesis for BLVRA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 109750   
    OMIM disorders: 614156  
    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
  • Hyperbiliverdinemia (HBLVD) [MIM:614156]: A condition characterized by a green discoloration of the skin,
    urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to
    bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or
    liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for BLVRA:    
    About MalaCards
    hyperbiliverdinemia    spontaneous pneumothorax    pneumothorax    primary spontaneous pneumothorax

    1 disease from the University of Copenhagen DISEASES database for BLVRA:
    Congenital heart block

    Find genes that share disorders with BLVRA           About GenesLikeMe

    Genetic Association Database (GAD): BLVRA
    Human Genome Epidemiology (HuGE) Navigator: BLVRA (3 documents)

    Export disorders for BLVRA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BLVRA gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with BLVRA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase. (PubMed id 8950184)1, 2, 9 Komuro A.... Tomita M. (Biochim. Biophys. Acta 1996)
    2. Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes. (PubMed id 8631357)1, 2, 9 Maines M.D.... McCoubrey W.K. Jr. (Eur. J. Biochem. 1996)
    3. A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice). (PubMed id 19580635)1, 2, 9 Gafvels M.... Stal P. (Liver Int. 2009)
    4. Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population. (PubMed id 19238116)1, 4, 9 Lin R....Jin L. (Pharmacogenet. Genomics 2009)
    5. Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization. (PubMed id 7929092)1, 2, 9 Yamaguchi T.... Nakajima H. (J. Biol. Chem. 1994)
    6. Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations. (PubMed id 19243019)1, 4, 9 Lin R....Jin L. (Hum. Mutat. 2009)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    8. Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions. (PubMed id 17402939)1, 7 Franklin E....Mantle T.J. (Biochem. J. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 644 HGNC: 1062 AceView: BLVRA Ensembl:ENSG00000106605 euGenes: HUgn644
    ECgene: BLVRA Kegg: 644 H-InvDB: BLVRA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BLVRA Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/blvra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BLVRA gene:
    Search GeneIP for patents involving BLVRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for BLVRA (Biliverdin Reductase A/BLVRA)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BLVRA  
     OriGene qPCR primer pairs and template standards for BLVRA   OriGene Protein Over-expression Lysate for BLVRA  
     OriGene MassSpec for BLVRA   OriGene clones in human, mouse for BLVRA  
     OriGene qSTAR qPCR primer pairs in human, mouse for BLVRA   OriGene Purified Protein for BLVRA  
     OriGene ORF clones in mouse, rat for BLVRA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BLVRA   OriGene Custom Protein Services for BLVRA  

     
     
     Block miRNA regulation of human, mouse, rat BLVRA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BLVRA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BLVRA Predesigned siRNA for gene silencing in human, mouse, rat BLVRA
     QuantiFast Probe-based Assays in human, mouse, rat BLVRA QuantiTect SYBR Green Assays in human, mouse, rat BLVRA
     PCR Arrays including human, mouse, rat BLVRA Search Chromatin IP Primers for BLVRA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BLVRA  GeneGlobe Interaction Network for BLVRA
     Regulatory tfbs in BLVRA promoter
     GenScript Custom Purified and Recombinant Proteins Services for BLVRA GenScript cDNA clones with any tag delivered in your preferred vector for BLVRA
     GenScript Custom Assay Services for BLVRA GenScript Custom overexpressing Cell Line Services for BLVRA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BLVRA (BIEA)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BLVRA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BLVRA antibodies
     BLVRA proteins
     BLVRA lysates
     Antibodies for BLVRA
     See all of Abcam's Antibodies, Kits and Proteins for BLVRA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BLVRA
     Proteins for BLVRA
     Antibodies for BLVRA
     ELISAs for BLVRA
     CLIAs for BLVRA



     Browse ESI BIO Cell Lines and PureStem Progenitors for BLVRA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLVRA
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BLVRA
     SwitchGear Promoter luciferase reporter plasmids for BLVRA
     ThermoFisher Antibody for BLVRA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLVRA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BLVRA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BLVRA
     LSBio Antibodies in human, mouse, rat for BLVRA
     Browse compounds at ApexBio
     Search Addgene for plasmids for BLVRA
      Search eBioscience for proteins for BLVRA
      Search eBioscience for elisas for BLVRA
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for BLVRA (33 products)
     antibodies-online kits for BLVRA (10 products)
     antibodies-online peptides for BLVRA
     antibodies-online proteins for BLVRA (15 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BLVRA gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4