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Aliases for BLVRA Gene

Aliases for BLVRA Gene

  • Biliverdin Reductase A 2 3
  • Biliverdin-IX Alpha-Reductase 3 4
  • BVR A 3 4
  • BLVR 3 4
  • BVR 3 4
  • EC 4
  • BVRA 3

External Ids for BLVRA Gene

Previous HGNC Symbols for BLVRA Gene

  • BLVR

Previous GeneCards Identifiers for BLVRA Gene

  • GC07P043444
  • GC07P043539
  • GC07P043571
  • GC07P043764
  • GC07P043683

Summaries for BLVRA Gene

Entrez Gene Summary for BLVRA Gene

  • The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for BLVRA Gene

BLVRA (Biliverdin Reductase A) is a Protein Coding gene. Diseases associated with BLVRA include hyperbiliverdinemia and pneumothorax. Among its related pathways are Metabolism and IL-10 Pathway. GO annotations related to this gene include biliverdin reductase activity.

UniProtKB/Swiss-Prot for BLVRA Gene

  • Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLVRA Gene

Genomics for BLVRA Gene

Regulatory Elements for BLVRA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BLVRA Gene

43,758,673 bp from pter
43,807,342 bp from pter
48,670 bases
Plus strand

Genomic View for BLVRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BLVRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLVRA Gene

Proteins for BLVRA Gene

  • Protein details for BLVRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Biliverdin reductase A
    Protein Accession:
    Secondary Accessions:
    • A8K747
    • O95019
    • Q86UX0
    • Q96QL4
    • Q9BRW8

    Protein attributes for BLVRA Gene

    296 amino acids
    Molecular mass:
    33428 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer.
    • Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems

    Three dimensional structures from OCA and Proteopedia for BLVRA Gene

neXtProt entry for BLVRA Gene

Proteomics data for BLVRA Gene at MOPED

Post-translational modifications for BLVRA Gene

  • Ubiquitination at Lys219, Lys234, Lys253, Lys261, and Lys269
  • Modification sites at PhosphoSitePlus

Other Protein References for BLVRA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BLVRA Gene

Domains for BLVRA Gene

Protein Domains for BLVRA Gene

Suggested Antigen Peptide Sequences for BLVRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P53004
  • Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
genes like me logo Genes that share domains with BLVRA: view

No data available for Gene Families for BLVRA Gene

Function for BLVRA Gene

Molecular function for BLVRA Gene

GENATLAS Biochemistry:
biliverdin reductase IX alpha,22kDa,expressed in adult liver
UniProtKB/Swiss-Prot CatalyticActivity:
Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H
UniProtKB/Swiss-Prot Function:
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor

Enzyme Numbers (IUBMB) for BLVRA Gene

Gene Ontology (GO) - Molecular Function for BLVRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004074 biliverdin reductase activity IDA 10858451
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with BLVRA: view
genes like me logo Genes that share phenotypes with BLVRA: view

Animal Model Products

miRNA for BLVRA Gene

miRTarBase miRNAs that target BLVRA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BLVRA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for BLVRA Gene

Localization for BLVRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLVRA Gene


Subcellular locations from

Jensen Localization Image for BLVRA Gene COMPARTMENTS Subcellular localization image for BLVRA gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BLVRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BLVRA: view

Pathways for BLVRA Gene

genes like me logo Genes that share pathways with BLVRA: view

Pathways by source for BLVRA Gene

1 Qiagen pathway for BLVRA Gene
1 BioSystems pathway for BLVRA Gene
3 Reactome pathways for BLVRA Gene
1 KEGG pathway for BLVRA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P53004-BIEA_HUMAN

  • Pathway: Porphyrin-containing compound metabolism; protoheme degradation

Interacting Proteins for BLVRA Gene

Gene Ontology (GO) - Biological Process for BLVRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006778 porphyrin-containing compound metabolic process TAS --
GO:0042167 heme catabolic process TAS 10858451
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IDA 10858451
genes like me logo Genes that share ontologies with BLVRA: view

Compounds for BLVRA Gene

(8) HMDB Compounds for BLVRA Gene

Compound Synonyms Cas Number PubMed IDs
  • (4Z,15Z)-Bilirubin IXa
  • 1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone
  • Formyl coenzyme A
  • (protoporphyrinato)iron
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate

(2) Drugbank Compounds for BLVRA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • beta-DPNH
606-68-8 target
53-84-9 target

(11) Novoseek inferred chemical compound relationships for BLVRA Gene

Compound -log(P) Hits PubMed IDs
biliverdin 96 47
bilirubin ixalpha 83.5 1
uridine diphosphate 72.8 1
phytochrome 53.9 5
hydride 52.2 1
genes like me logo Genes that share compounds with BLVRA: view

Transcripts for BLVRA Gene

Unigene Clusters for BLVRA Gene

Biliverdin reductase A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BLVRA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLVRA Gene

No ASD Table

Relevant External Links for BLVRA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BLVRA Gene

mRNA expression in normal human tissues for BLVRA Gene

Protein differential expression in normal tissues for BLVRA Gene

This gene is overexpressed in Spleen (10.2) and Breast (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BLVRA Gene

SOURCE GeneReport for Unigene cluster for BLVRA Gene Hs.488143

mRNA Expression by UniProt/SwissProt for BLVRA Gene

Tissue specificity: Liver
genes like me logo Genes that share expressions with BLVRA: view

Expression partners for BLVRA Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BLVRA Gene

Orthologs for BLVRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BLVRA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BLVRA 35
  • 88.74 (n)
  • 92.23 (a)
  • 92 (a)
(Canis familiaris)
Mammalia BLVRA 35
  • 88.96 (n)
  • 93.58 (a)
  • 94 (a)
(Mus musculus)
Mammalia Blvra 35
  • 83.05 (n)
  • 83.85 (a)
Blvra 16
Blvra 36
  • 83 (a)
(Pan troglodytes)
Mammalia BLVRA 35
  • 100 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Blvra 35
  • 83.62 (n)
  • 83.39 (a)
(Monodelphis domestica)
Mammalia BLVRA 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia BLVRA 36
  • 62 (a)
(Gallus gallus)
Aves BLVRA 35
  • 62.53 (n)
  • 60.58 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia BLVRA 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia blvra 35
  • 59.85 (n)
  • 54.38 (a)
(Danio rerio)
Actinopterygii blvra 35
  • 58.02 (n)
  • 55.93 (a)
blvra 36
  • 52 (a)
Species with no ortholog for BLVRA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BLVRA Gene

Gene Tree for BLVRA (if available)
Gene Tree for BLVRA (if available)

Paralogs for BLVRA Gene

No data available for Paralogs for BLVRA Gene

Variants for BLVRA Gene

Sequence variations from dbSNP and Humsavar for BLVRA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7738 -- 43,807,004(+) AAAGG(A/G)CCTGG reference, synonymous-codon
rs849161 -- 43,781,854(+) caggg(A/G)gttaa intron-variant
rs849162 -- 43,782,253(+) TAGAG(A/G)AAGGA intron-variant
rs849163 -- 43,783,526(-) GATAG(A/G)CTCGT intron-variant
rs849164 -- 43,785,054(+) GAAAT(A/C)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BLVRA Gene

Variant ID Type Subtype PubMed ID
nsv464441 CNV Loss 19166990

Relevant External Links for BLVRA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLVRA Gene

Disorders for BLVRA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BLVRA Gene in MalaCards »

(3) Diseases for BLVRA Gene including...

(1) OMIM Diseases for BLVRA Gene (109750)


  • Hyperbiliverdinemia (HBLVD) [MIM:614156]: A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. {ECO:0000269 PubMed:19580635}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for BLVRA Gene

Relevant External Links for BLVRA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BLVRA: view

No data available for Novoseek inferred disease relationships and Genatlas for BLVRA Gene

Publications for BLVRA Gene

  1. Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization. (PMID: 7929092) Yamaguchi T. … Nakajima H. (J. Biol. Chem. 1994) 3 4 23
  2. Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes. (PMID: 8631357) Maines M.D. … McCoubrey W.K. Jr. (Eur. J. Biochem. 1996) 3 4 23
  3. Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase. (PMID: 8950184) Komuro A. … Tomita M. (Biochim. Biophys. Acta 1996) 3 4 23
  4. Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population. (PMID: 19238116) Lin R. … Jin L. (Pharmacogenet. Genomics 2009) 3 23 48
  5. Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations. (PMID: 19243019) Lin R. … Jin L. (Hum. Mutat. 2009) 3 23 48

Products for BLVRA Gene

Sources for BLVRA Gene

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