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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BLVRA Gene

protein-coding   GIFtS: 64
GCID: GC07P043798

Biliverdin Reductase A


(Previous symbol: BLVR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Biliverdin Reductase A1 2     BVR A2 3
BLVR1 2 3     BVRA2
Biliverdin-IX Alpha-Reductase2 3     EC 1.3.1.243
BVR2 3     

External Ids:    HGNC: 10621   Entrez Gene: 6442   Ensembl: ENSG000001066057   OMIM: 1097505   UniProtKB: P530043   

Export aliases for BLVRA gene to outside databases

Previous GC identifers: GC07P043444 GC07P043539 GC07P043571 GC07P043764 GC07P043683


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BLVRA Gene:
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the
conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated
with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. (provided by
RefSeq, Dec 2011)

GeneCards Summary for BLVRA Gene: 
BLVRA (biliverdin reductase A) is a protein-coding gene. Diseases associated with BLVRA include hyperbiliverdinemia, and congenital heart block, and among its related super-pathways are Heme degradation and Heme biosynthesis. GO annotations related to this gene include nucleotide binding and biliverdin reductase activity.

UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
Function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the
concomitant oxidation of a NADH or NADPH cofactor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BLVRA gene promoter:
         TBP   Max1   RFX1   Sox5   AML1a   Nkx2-2   Lmo2   E47   Hand1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBLVRA promoter sequence
   Search SABiosciences Chromatin IP Primers for BLVRA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLVRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

BLVRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BLVRA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P043798:  view genomic region     (about GC identifiers)

Start:
43,798,272 bp from pter      End:
43,846,941 bp from pter
Size:
48,670 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 43,837,746-43,886,418     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004 (See protein sequence)
Recommended Name: Biliverdin reductase A precursor  
Size: 296 amino acids; 33428 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer
Subcellular location: Cytoplasm
Miscellaneous: Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9)
and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems
1 PDB 3D structure from and Proteopedia for BLVRA:
2H63 (3D)    
Secondary accessions: A8K747 O95019 Q86UX0 Q96QL4 Q9BRW8

Explore the universe of human proteins at neXtProt for BLVRA: NX_P53004

Explore proteomics data for BLVRA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53004

  • BLVRA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BLVRA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000703.2  NP_001240752.1  

    ENSEMBL proteins: 
     ENSP00000265523   ENSP00000385757   ENSP00000412005  
    Reactome Protein details: P53004
    Human Recombinant Protein Products for BLVRA: 
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    Cloud-Clone Corp. Proteins for BLVRA 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    BLVRA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017094 Biliverdin_Rdtase_A
     IPR015249 Biliverdin_Rdtase_cat
     IPR000683 Oxidoreductase_N
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P53004

    ProtoNet protein and cluster: P53004

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
    Similarity: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily


    BLVRA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIEA_HUMAN, P53004
    Function: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the
    concomitant oxidation of a NADH or NADPH cofactor
    Catalytic activity: Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H

         Genatlas biochemistry entry for BLVRA:
    biliverdin reductase IX alpha,22kDa,expressed in adult liver

         Enzyme Number (IUBMB): EC 1.3.1.241

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004074biliverdin reductase activity IDA10858451
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
         
    BLVRA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BLVRA:
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BLVRA 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BLVRA 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BLVRA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1heme degradation
    Heme degradation0.80
    heme degradation0.80
    2Heme Biosynthesis
    Metabolism of porphyrins0.69
    3Metabolism
    Metabolism0.40
    4Glucuronidation
    Porphyrin and chlorophyll metabolism0.38
    5IL-10 Pathway
    IL-10 Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BLVRA
        IL-10 Pathway

    1 BioSystems Pathway for BLVRA
        heme degradation


    3        Reactome Pathways for BLVRA
        Metabolism of porphyrins
    Metabolism
    Heme degradation


    1         Kegg Pathway  (Kegg details for BLVRA):
        Porphyrin and chlorophyll metabolism

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
    Pathway: Porphyrin-containing compound metabolism; protoheme degradation


    BLVRA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BLVRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for BLVRA (P530042, 3 ENSP000002655234) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    C12orf44Q9BSB43I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    GBASO753233I2D: score=1 
    PRKCZQ055133I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006778porphyrin-containing compound metabolic process TAS--
    GO:0042167heme catabolic process TAS10858451
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process IDA10858451

    BLVRA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BLVRA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BLVRA (BIEA)

    8 HMDB Compounds for BLVRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-4--
    Biliverdin1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone (see all 7)114-25-0--
    Formyl-CoAFormyl coenzyme A 13131-49-2--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 DrugBank Compounds for BLVRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17402939
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--10592235

    10/11 Novoseek inferred chemical compound relationships for BLVRA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliverdin 96 90 19614742 (5), 19509285 (4), 19690164 (3), 18276984 (2) (see all 35)
    bilirubin ixalpha 83.5 1 12196151 (1)
    uridine diphosphate 72.8 2 19238116 (1)
    phytochrome 53.9 7 9165746 (3), 10517855 (2)
    hydride 52.2 1 12196151 (1)
    haem 47.7 1 8631357 (1)
    nadph 46.2 3 12196151 (1), 15226268 (1), 8631357 (1)
    threonine 41.5 3 14988408 (1), 15870194 (1), 11278740 (1)
    nadh 35 1 8631357 (1)
    serine 27.5 9 15870194 (4), 14988408 (1), 11278740 (1)

    Search CenterWatch for drugs/clinical trials and news about BLVRA / BIEA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BLVRA gene (2 alternative transcripts): 
    NM_000712.3  NM_001253823.1  

    Unigene Cluster for BLVRA:

    Biliverdin reductase A
    Hs.488143  [show with all ESTs]
    Unigene Representative Sequence: BX647539
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265523(uc003tir.3) ENST00000402924(uc010kxv.3) ENST00000424330
    ENST00000453612 ENST00000486984

    miRNA
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    Additional mRNA sequence: 

    AK291862.1 BC005902.1 BC008456.1 BX647539.1 U34877.1 X93086.1 

    8 DOTS entries:

    DT.447342  DT.100788322  DT.100788320  DT.75156165  DT.95373175  DT.121113103  DT.121113104  DT.86859543 

    24/173 AceView cDNA sequences (see all 173):

    AA970668 AI249710 C01830 AI478194 AA595133 AI522038 BM563558 N31107 
    AA594489 CA423398 BM893943 BM710258 BU156742 BM708417 BU196520 BM701812 
    H28171 CA418616 BQ130539 BC008456 NM_000712 AA506016 N21095 BU689144 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BLVRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGGGAAAC
    BLVRA Expression
    About this image


    See BLVRA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BLVRA

    SOURCE GeneReport for Unigene cluster: Hs.488143

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
    Tissue specificity: Liver

        SABiosciences Expression via Pathway-Focused PCR Array including BLVRA: 
              Drug Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLVRA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BLVRA gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Blvra1 , 5 biliverdin reductase A1, 5 83.05(n)1
    83.85(a)1
      2 (61.76 cM)5
    1097781  NM_026678.41  NP_080954.41 
     1270706655 
    chicken
    (Gallus gallus)
    Aves BLVRA1 biliverdin reductase A 62.7(n)
    60.84(a)
      420776  XM_418872.2  XP_418872.2 
    lizard
    (Anolis carolinensis)
    Reptilia BLVRA6
    biliverdin reductase A
    57(a)
    1 ↔ 1
    6(50952171-51016356)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420134682   -- 75.51(n)    142013468 
    zebrafish
    (Danio rerio)
    Actinopterygii blvra1 biliverdin reductase A 58.06(n)
    56.27(a)
      767661  NM_001076601.1  NP_001070069.1 


    ENSEMBL Gene Tree for BLVRA (if available)
    TreeFam Gene Tree for BLVRA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/952 SNPs in BLVRA are shown (see all 952)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180082001,2
    F--43771460(+) ATGGAG/AGGCCC 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1157875121,2
    C,F--43771477(+) CAGGCT/ATTCCC 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1869029421,2
    --43771494(+) CCTCTA/GGGTGT 2 -- us2k10--------
    rs102403881,2
    C,F,H--43771710(+) TTTCCG/AAGAAA 2 -- us2k16Minor allele frequency- A:0.00NS EA NA 598
    rs2019006371,2
    --43772399(+) TTGCC-/ATCGAG 2 -- us2k10--------
    rs1404801121,2
    --43772401(+) GCCATC/TGAGAT 2 -- us2k10--------
    rs795691851,2
    F--43772448(+) TGGATG/ATGTTG 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs16375301,2
    C,F,H--43772576(+) TCTCTC/TTGCAC 2 -- us2k1 trp325Minor allele frequency- T:0.16NS EA NA WA CSA 2519
    rs172457781,2
    C,F--43772680(+) GAACGC/ATGCCT 2 -- us2k12Minor allele frequency- A:0.04NS WA 286
    rs172457851,2
    C,F--43772787(+) ATCAGG/AATCCC 2 -- us2k13Minor allele frequency- A:0.10NS WA NA 398

    HapMap Linkage Disequilibrium report for BLVRA (43798272 - 43846941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BLVRA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv464441CNV Loss19166990


    Human Gene Mutation Database (HGMD): BLVRA
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BLVRA
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109750    OMIM disorders: --

    UniProtKB/Swiss-Prot: BIEA_HUMAN, P53004
  • Hyperbiliverdinemia (HBLVD) [MIM:614156]: A condition characterized by a green discoloration of the skin,
    urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to
    bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or
    liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for BLVRA:    About MalaCards
    hyperbiliverdinemia    congenital heart block    jaundice    cholestasis
    encephalomyelitis    liver cirrhosis    acute myeloid leukemia    hypoxia
    atherosclerosis    myeloid leukemia    alzheimer's disease    hypertension
    endotheliitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for BLVRA:
    Congenital heart block

    BLVRA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): BLVRA
    Human Genome Epidemiology (HuGE) Navigator: BLVRA (3 documents)

    Export disorders for BLVRA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BLVRA gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with BLVRA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase. (PubMed id 8950184)1, 2, 9 Komuro A.... Tomita M. (1996)
    2. Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes. (PubMed id 8631357)1, 2, 9 Maines M.D.... McCoubrey W.K. Jr. (1996)
    3. A novel mutation in the biliverdin reductase-A gene c ombined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice). (PubMed id 19580635)1, 2, 9 GAYfvels M....StAYl P. (2009)
    4. Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population. (PubMed id 19238116)1, 4, 9 Lin R....Jin L. (2009)
    5. Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization. (PubMed id 7929092)1, 2, 9 Yamaguchi T.... Nakajima H. (1994)
    6. Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations. (PubMed id 19243019)1, 4, 9 Lin R....Jin L. (2009)
    7. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    8. Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions. (PubMed id 17402939)1, 7 Franklin E....Mantle T.J. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644 HGNC: 1062 AceView: BLVRA Ensembl:ENSG00000106605 euGenes: HUgn644
    ECgene: BLVRA Kegg: 644 H-InvDB: BLVRA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BLVRA Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/blvra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BLVRA gene:
    Search GeneIP for patents involving BLVRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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