Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BLMH Gene

protein-coding   GIFtS: 66
GCID: GC17M028575

bleomycin hydrolase

 Explore 21 diseases affiliated with
BLMH via our new
 Human Malady Compendium 
Biological research products
for BLMH
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Bleomycin Hydrolase1 2
BH1 2 3
BMH2 3 5
BLM Hydrolase2 3
EC 3.4.22.403 8

External Ids:    HGNC: 10591   Entrez Gene: 6422   Ensembl: ENSG000001085787   OMIM: 6024035   UniProtKB: Q138673   

Export aliases for BLMH gene to outside databases

Previous GC identifers: GC17M028328 GC17M030481 GC17M028720 GC17M025599 GC17M024785


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BLMH:
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the
only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential
component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of
the cysteine protease papain superfamily. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867
Function: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor
drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal
and malignant cells from BLM toxicity (By similarity)

Gene Wiki entry for BLMH


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BLMH gene promoter:
         HFH-3   GR   Pbx1a   GR-beta   Tal-1beta   E47   AREB6   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBLMH promoter sequence
   Search SABiosciences Chromatin IP Primers for BLMH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLMH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

BLMH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BLMH gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M028575:  view genomic region     (about GC identifiers)

Start:
28,575,218 bp from pter      End:
28,619,074 bp from pter
Size:
43,857 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867 (See protein sequence)
Recommended Name: Bleomycin hydrolase  
Size: 455 amino acids; 52562 Da
Subunit: Homohexamer
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for BLMH:
1CB5 (3D)        2CB5 (3D)    
Secondary accessions: B2R796 Q53F86 Q9UER9

Explore the universe of human proteins at neXtProt for BLMH: NX_Q13867

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13867

  • 4/17 DME Specific Peptides for BLMH (Q13867) (see all 17)
     VWFGCDV  YVYEVVV  VNDPRPQ  DGGQWDM 

    BLMH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000377.1  
    ENSEMBL proteins: 
     ENSP00000261714   ENSP00000462353   ENSP00000468681   ENSP00000462442   ENSP00000468486  
     ENSP00000466527   ENSP00000466948   ENSP00000378296  
    Reactome Protein details: Q13867
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BLMH (BLMH/Bleomycin Hydrolase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: BLMH
    OriGene Custom Protein Services for BLMH 
    GenScript Custom Purified and Recombinant Proteins Services for BLMH
    Novus Biologicals BLMH Proteins
    Novus Biologicals BLMH Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for BLMH
    Uscn Proteins for BLMH

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    BLMH for ontologies           About GeneDecksing



    BLMH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BLMH (BLMH/Bleomycin Hydrolase)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BLMH 
    GenScript Custom Superior Antibodies Services for BLMH
    Novus Biologicals BLMH Antibodies
    Search for Antibodies for BLMH at Abcam  
    Uscn Antibodies for BLMH
    Search ThermoFisher Antibodies for BLMH

    Assay Products for BLMH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BLMH
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BLMH


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BLMH for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004134 Peptidase_C1B
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry Q13867

    ProtoNet protein and cluster: Q13867

    1 Blocks protein family: IPB004134 Peptidase C1-like family

    UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867
    Similarity: Belongs to the peptidase C1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867
    Function: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor
    drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal
    and malignant cells from BLM toxicity (By similarity)
    Catalytic activity: Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of
    beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but
    amino acid arylamides of Met, Leu and Ala are preferred

         Genatlas biochemistry entry for BLMH:
    bleomycin hydrolase,neutral cysteine protease,papain superfamily,widely expressed,maybe involved in bleomycin induced
    pulmonary fibrosis

    Enzyme Number (IUBMB): EC 3.4.22.401 2

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: BLMH
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BLMH
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate BLMH (see all 14):
    hsa-miR-561 hsa-miR-4272 hsa-miR-3065-3p hsa-miR-589* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidBLMH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BLMH (see all 7)
    OriGene shRNA RFP: BLMH
    OriGene siRNA: BLMH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BLMH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BLMH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLMH (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLMH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BLMH (NM_000386)
    Sino Biological Human cDNA Clone for BLMH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BLMH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLMH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BLMH
    Search LifeMap BioReagents cell lines for BLMH

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLMH

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity TAS9546396
    GO:0004180carboxypeptidase activity TAS9546396
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI11350084
    GO:0008233peptidase activity ----


    BLMH for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BLMH:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Blmhtm1Geh for BLMH
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Blmh):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging 

    BLMH for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Adaptive Immune System0.59
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Class I MHC mediated antigen processing & presentation0.83
    3Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
    Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for BLMH
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
    Immune System



    BLMH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BLMH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for BLMH (Q138671, 2, 3 ENSP000002617144) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIOO759622, 3, ENSP000003392994MINT-64162 I2D: score=5 STRING: ENSP00000339299
    PDPK1O155302, 3MINT-8265452 I2D: score=2 
    APPP05067-41, ENSP000002849814EBI-718504,EBI-302641 I2D: score=3 STRING: ENSP00000284981
    KBTBD7Q8WVZ93, ENSP000003687974I2D: score=4 STRING: ENSP00000368797
    RPL11P629133, ENSP000003636764I2D: score=3 STRING: ENSP00000363676
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006508proteolysis IEA--
    GO:0009636response to toxin IEA--
    GO:0042493response to drug IEA--


    BLMH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BLMH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BLMH
    5 Novoseek chemical compound relationships for BLMH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bleomycin 91.7 156 8620487 (7), 8639621 (4), 10404591 (3), 12167044 (3) (see all 50)
    thimet 66 2 14734113 (1)
    cysteine 64.5 25 8889821 (3), 10404591 (2), 8620487 (2), 9855622 (2) (see all 14)
    leucine 31.8 3 15187416 (1), 16455981 (1)
    lactate 0 1 9371686 (1)

    Search CenterWatch for drugs/clinical trials and news about BLMH 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BLMH gene: 
    NM_000386.3  

    Unigene Cluster for BLMH:

    Bleomycin hydrolase
    Hs.371914  [show with all ESTs]
    Unigene Representative Sequence: NM_000386
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261714(uc002hez.2 uc010wbn.2) ENST00000578795 ENST00000578090
    ENST00000577623 ENST00000579957 ENST00000581037 ENST00000577306 ENST00000584603
    ENST00000582669 ENST00000579325 ENST00000580709 ENST00000577290 ENST00000582749
    ENST00000394819

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: BLMH
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BLMH
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate BLMH (see all 14):
    hsa-miR-561 hsa-miR-4272 hsa-miR-3065-3p hsa-miR-589* hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidBLMH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BLMH (see all 7)
    OriGene shRNA RFP: BLMH
    OriGene siRNA: BLMH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BLMH
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLMH (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLMH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BLMH (NM_000386)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BLMH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLMH 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLMH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BLMH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLMH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLMH

    Additional cDNA sequence: 

    AF091082.1 AK057600.1 AK223403.1 AK301948.1 AK312896.1 BC003616.2 BT007018.1 X92106.1 

    17 DOTS entries:

    DT.101983117  DT.315911  DT.95124813  DT.100807028  DT.95124820  DT.100810339  DT.100810343  DT.100810344 
    DT.417729  DT.120916053  DT.92458086  DT.95124811  DT.100693584  DT.92458092  DT.95124772  DT.97859808 
    DT.75186169 

    24/342 AceView cDNA sequences (see all 342):

    BQ072971 AA927540 BM676957 BQ424536 AA994117 AA705502 BU167345 AI318426 
    AU130273 AA774218 AA701306 BQ687565 BE782971 CA426434 BE780996 W74447 
    AA417881 AU121157 BQ690347 BE396899 AU123836 AU279450 CB988732 AA903743 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for BLMH (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a ·
    SP1:                                                                                      -     -                       -     -     -                           
    SP2:                                                                                      -     -                       -     -     -                 -         
    SP3:                                                                                                                    -     -     -                 -         
    SP4:                          -     -                                                     -     -                                                               
    SP5:                          -     -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 12b ^ 13 ^ 14a · 14b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for BLMH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BLMH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTCAGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See BLMH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BLMH

    SOURCE GeneReport for Unigene cluster: Hs.371914
        SABiosciences Expression via Pathway-Focused PCR Array including BLMH: 
              Cancer Drug Resistance in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLMH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BLMH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLMH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLMH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLMH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BLMH gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Blmh1 , 5 bleomycin hydrolase1, 5 91.14(n)1
    93.19(a)1
      11 (46.16 cM)5
    1041841  NM_178645.41  NP_848760.11 
     769248095 
    chicken
    (Gallus gallus)
    Aves BLMH1 bleomycin hydrolase 74.51(n)
    75.38(a)
      395996  NM_205104.1  NP_990435.1 
    lizard
    (Anolis carolinensis)
    Reptilia BLMH6
    --
    73(a)
    1 ↔ 1
    GL343462.1(509660-521692)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98462 Xenopus laevis transcribed sequence with moderate similarity more 77.18(n)    BJ033232.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb13c012 wufb13c01 75.48(n)   336541  BC055572.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14401 , 3 cysteine-type endopeptidase3
    CG14401
    54(a)
    (best of 2)3
    59.22(n)1
    57.6(a)1
      7E93
    317761  NM_001103437.11  NP_001096907.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAP3(YNL239W)4
    LAP31
    Cysteine aminopeptidase with homocysteine-thiolactonase more4
    Lap3p1
    48.38(n)1
    40.86(a)1
      14(200569-201933)4
    8554821, 4  NP_014160.21, 4 


    ENSEMBL Gene Tree for BLMH (if available)
    TreeFam Gene Tree for BLMH (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/676 NCBI SNPs in BLMH are shown (see all 676    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10505651,2
    C,F,H,non-pathogenic28426358(-) CCATTA/GTCCTG 2 I V mis1 ese336Minor allele frequency- N:0.00EA MN NA NS WA CSA EU 11573
    rs116537771,2
    C,F,H,--24785364(+) GAGCCA/CCCTGG 1 -- ds500116Minor allele frequency- C:0.03NS EA NA CSA WA 1889
    rs771516521,2
    --24785660(+) TGCACC/ACCCCA 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs31908841,2
    C,F,H,--24786111(-) GTCTCC/TACCAG 1 -- ut31 ese314Minor allele frequency- T:0.03MN NS EA NA WA 1156
    rs777683791,2
    F,--24787062(+) TCTGCT/CTAACC 1 -- int11Minor allele frequency- C:0.08NA 120
    rs766121231,2
    F--24787519(-) ATTCTG/ATGGGT 1 -- int11Minor allele frequency- A:0.50NA 4
    rs72123101,2
    C,F,H,--24787977(+) aaagaG/Agtcac 1 -- int1 trp35Minor allele frequency- A:0.10NS EA WA 478
    rs739878091,2
    C,--24788757(+) TATAGT/CAAACA 1 -- int12Minor allele frequency- C:0.04WA 120
    rs773090661,2
    --24789352(+) ATGTTG/ACTCAA 1 -- int12Minor allele frequency- A:0.15CSA WA 120
    rs169656451,2
    C,F,H,--24789476(+) GTCTAA/GTTTTG 1 -- int115Minor allele frequency- G:0.03NA NS EA WA 1664

    HapMap Linkage Disequilibrium report for BLMH (28575218 - 28619074 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BLMH
         1 CNV: 102436
    Human Gene Mutation Database (HGMD): BLMH

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BLMH
    DNA2.0 Custom Variant and Variant Library Synthesis for BLMH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BLMH for disorders           About GeneDecksing

    OMIM gene information: 602403   
    OMIM disorders: 104300  
    20/21 diseases for BLMH (see all 21):    About MalaCards
    pityriasis rubra pilaris    hydrops fetalis    mutagen sensitivity    testicular germ cell cancer
    iron overload    alpha thalassemia    intellectual disability    autistic disorder
    alzheimer's disease    atopic dermatitis    neurodegenerative disease    germ cell cancer
    thalassemia    pulmonary fibrosis    dermatitis    dementia
    homocysteine    fibrosis    hepatocellular carcinoma    pneumonia

    1 disease from the University of Copenhagen DISEASES database for BLMH:
    Alzheimer's disease

    7 Novoseek disease relationships for BLMH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 53 12 9818937 (2), 10350576 (2), 10822352 (2), 10973933 (1) (see all 8)
    senile plaques 26.5 2 10350576 (1), 11350084 (1)
    neurodegenerative diseases 4.98 1 12604387 (1)
    dementia 0 1 10530514 (1)
    tumors 0 7 9331073 (2), 8620487 (2), 10404591 (1), 12555812 (1)
    lymphoma 0 1 8620487 (1)
    cancer 0 3 18398146 (1), 8063738 (1)

    Genetic Association Database (GAD): BLMH
    Human Genome Epidemiology (HuGE) Navigator: BLMH (9 documents)

    Export disorders for BLMH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BLMH gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with BLMH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. (PubMed id 8620487)1, 2, 9 Ferrando A.A.... Lopez-Otin C. (1996)
    2. Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. (PubMed id 15900213)1, 4, 9 Nuver J....Gietema J.A. (2005)
    3. Crystal structure of human bleomycin hydrolase, a self- compartmentalizing cysteine protease. (PubMed id 10404591)1, 2, 9 O'Farrell P.A.... Joshua-Tor L. (1999)
    4. Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. (PubMed id 8639621)1, 2, 9 Broemme D.... Payan D.G. (1996)
    5. Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase. (PubMed id 9407121)1, 3, 9 Ferrando A.A....Lopez-Otin C. (1997)
    6. Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase. (PubMed id 9331073)1, 3, 9 Montoya S.E....Lazo J.S. (1997)
    7. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PubMed id 11436125)1, 4, 9 Prince J.A....Brookes A.J. (2001)
    8. Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. (PubMed id 11099722)1, 4, 9 Hu C.J....Chang J.G. (2000)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. (PubMed id 12082022)1, 4 Tuimala J....Norppa H. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 642 HGNC: 1059 AceView: BLMH Ensembl:ENSG00000108578 euGenes: HUgn642
    ECgene: BLMH H-InvDB: BLMH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BLMH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BLMH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BLMH gene:
    Search GeneIP for patents involving BLMH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for BLMH (BLMH/Bleomycin Hydrolase)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for BLMH (BLMH/Bleomycin Hydrolase)  
     Browse OriGene Antibodies   OriGene shRNA RFP for BLMH  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BLMH   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLMH  
     OriGene Protein Over-expression Lysate for BLMH   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BLMH   OriGene 3'-UTR Clone for BLMH  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLMH   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLMH  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BLMH   OriGene Custom Protein Services for BLMH  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BLMH
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BLMH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLMH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BLMH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLMH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLMH
     GenScript Custom Purified and Recombinant Proteins Services for BLMH GenScript cDNA clones with any tag delivered in your preferred vector for BLMH
     GenScript Custom Assay Services for BLMH GenScript Custom Superior Antibodies Services for BLMH
     GenScript Custom overexpressing Cell Line Services for BLMH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BLMH promoter
     Search Chromatin IP Primers for BLMH
     RT2 qPCR Primer Assay in human, mouse, rat BLMH
     GNC Network for BLMH
     SABiosciences PCR Arrays including human, mouse, rat BLMH
     Search Tocris compounds for BLMH
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for BLMH
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BLMH antibodies
     BLMH proteins
     BLMH lysates
     Search for Antibodies for BLMH at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for BLMH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BLMH




     BLMH Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BLMH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLMH
     SwitchGear 3'UTR luciferase reporter plasmids for BLMH
     SwitchGear Promoter luciferase reporter plasmids for BLMH
     Search ThermoFisher Antibodies for BLMH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLMH
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BLMH gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4