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BLMH Gene

protein-coding GIFtS: 66

GC17M025599

bleomycin hydrolase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BH ^¹, ², ³
BMH ^², ³, ⁵
EC 3.4.22.40 ^³

Descriptions
BLM hydrolase ^³
bleomycin hydrolase ^²

External Ids
HGNC: 1059¹
Entrez Gene: 642²
UniProtKB: Q13867³
Ensembl: ENSG00000108578⁷

Search outside databases for aliases for BLMH gene

Previous GC identifers: GC17M028328 GC17M030481 GC17M028720

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BLMH:

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through

evolution; however, the only known activity of the enzyme is metabolic inactivation of the

glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for

cancer. The protein contains the signature active site residues of the cysteine protease papain

superfamily. [provided by RefSeq]

UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867

Function: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the

inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its

B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BLMH gene

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

BLMH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M025599: (about GC identifiers)

Start:	25,599,349 bp from pter
End:	25,643,204 bp from pter
Size:	43,856 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867 (See protein sequence)

Recommended Name: Bleomycin hydrolase

Size: 455 amino acids; 52562 Da

Subunit: Homohexamer

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1CB5 (3D)

2CB5 (3D)

Secondary accessions: Q53F86 Q9UER9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000377.1

ENSEMBL proteins:

ENSP00000261714 ENSP00000378296

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BLMH)
	Human Recombinant Proteins from Abnova (BLMH)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	IEA	--
GO:0005634	nucleus	TAS	8639621
GO:0005737	cytoplasm	TAS	8639621

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Antibodies for BLMH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BLMH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (BLMH), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BLMH)
	Novus Biologicals Antibodies for BLMH

Assays for BLMH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13867

ProtoNet protein and cluster: Q13867

1 Blocks protein family: IPB004134 Peptidase C1-like family

UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867

Similarity: Belongs to the peptidase C1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BLMH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BLMH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000386

Applied Biosystems Silencer® siRNAs for BLMH

Sigma-Aldrich siRNA and siRNA Panels for BLMH

Sigma-Aldrich shRNA for BLMH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BLMH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000386
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000386
untagged cDNA clone in CMV expression vector: NM_000386

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000386

UniProtKB/Swiss-Prot: BLMH_HUMAN, Q13867

Function: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the

inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its

B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By

similarity)

Catalytic activity: Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a

carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The

specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are

preferred

Enzyme Number (IUBMB): EC 3.4.22.40

Genatlas biochemistry entry for BLMH:

bleomycin hydrolase,neutral cysteine protease,papain superfamily,widely expressed,maybe involved in

bleomycin induced pulmonary fibrosis

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Blmh):

	behavior/neurological	growth/size	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	limbs/digits/tail	skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004177	aminopeptidase activity	TAS	9546396
GO:0004180	carboxypeptidase activity	TAS	9546396
GO:0004197	cysteine-type endopeptidase activity	TAS	8639621
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for BLMH (Your Favorite Gene powered by Ingenuity)

Lysine Degradation

GeneDecks BLMH for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BLMH

5/12 Interacting proteins for BLMH (ENSP00000261714³ Q13867²) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BLMH	Q13867²	MINT-68470
TRIO	O75962²	MINT-64162
NPB	ENSP00000332766³	STRING (score=.93)
BAX	ENSP00000293288³	STRING (score=.9)
BCL2L1	ENSP00000365230³	STRING (score=.881)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	9546396
GO:0009636	response to toxin	IEA	--
GO:0042493	response to drug	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BLMH
1 Novoseek chemical compound relationship for BLMH gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	24.77	3	15187416 (1), 16455981 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BLMH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BLMH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000386

Sigma-Aldrich siRNA and siRNA Panels for BLMH

Sigma-Aldrich shRNA for BLMH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000386

REFSEQ mRNAs for BLMH gene:

NM_000386.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000386

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000386
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000386
                                 untagged cDNA clone in CMV expression vector: NM_000386

Additional cDNA sequence:

AF091082.1 AK057600.1 AK223403.1 AK301948.1 AK312896.1 BC003616.2 BT007018.1 X92106.1

17 DOTS entries:

DT.101983117 DT.315911 DT.95124813 DT.100807028 DT.95124820 DT.100810339 DT.100810343 DT.100810344

DT.417729 DT.120916053 DT.92458086 DT.75186169 DT.100693584 DT.95124811 DT.95124772 DT.97859808

DT.92458092

24/342 AceView cDNA sequences (see all 342 ):

CA426434 BQ690347 AI189260 BM463898 W74447 AA631008 CA416026 AA774218

AI056959 BC003616 AI745577 CB114960 BF002346 NM_000386 BQ639431 AA417881

BF055310 BQ072971 BE513584 AU279450 AI318426 BM676957 BM792704 BQ052359

highest scoring ESTs for BLMH:

X92106 AA223448 AU077335 AU098904 BM755543 AA071022 AA113907 AL552976 AL559155 AL702789

Unigene Cluster for BLMH:

Bleomycin hydrolase

Hs.371914 [show with all ESTs]

Unigene Representative Sequence: NM_000386

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for BLMH (see all 15 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·
SP1:																													-		-								-		-		-
SP2:																													-		-								-		-		-						-
SP3:																																							-		-		-						-
SP4:									-		-																		-		-
SP5:									-		-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	12b	^	13	^	14a	·	14b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for BLMH

2 Ensembl transcripts including schematic representations:

ENST00000261714 ENST00000394819

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BLMH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BLMH

¹ / ² / ³

4 probe-sets matching BLMH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37700_at²^{, 3}	U95-A	1	1.00	1.00	0.84	1.08	X92106	1.00	0.90	0.95	1
394_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.93	X92106	1.00	0.90	0.95	1
202179_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000386	0.60	1.00	0.82	1
202179_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BLMH for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCTCAGTCA

SOURCE GeneReport for Unigene cluster: Hs.371914
Expression variation in blood from EXPOLDB for BLMH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BLMH gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BLMH¹	--	bleomycin hydrolase	93.7(n) 95.16(a)	480635 XM_537755.2 XP_537755.2
chimpanzee (Pan troglodytes)	BLMH¹	--	bleomycin hydrolase	99.83(n) 100(a)	454555 XM_511383.2 XP_511383.2
cow (Bos taurus)	BLMH¹	--	bleomycin hydrolase	92.77(n) 93.81(a)	504483 XM_580618.3 XP_580618.3
rat (Rattus norvegicus)	Blmh¹	--	bleomycin hydrolase	90.92(n) 93.63(a)	287552 NM_001034163.1 NP_001029335.1
mouse (Mus musculus)	Blmh^{1, 5}	11⁵	bleomycin hydrolase^{1, 5}	91.14(n)¹ 93.19(a)¹	104184¹ NM_178645.2¹ NP_848760.1¹ AA103506⁵ AI035728⁵ (see all 27)

About this table Species with no ortholog for BLMH

ENSEMBL Gene Tree for BLMH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/165 NCBI SNPs in BLMH are shown (see all 165 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6505165^1,2	A,C,F	25598975(+)	`GCAAAC/TTCAGT`	1	--	ng5¹		3		NA	140
	rs3190884^1,2	C,F,H	25600031(-)	`GTCTCC/TACCAG`	1	--	ut3¹ ese³		9		MN EU EA WA	1022
	rs1050565^1,2	C,F,H	25600202(-)	`CCATTA/GTCCTG`	1	I/V	mis¹ ese³		11		EA MN NA EU WA	2396
--	rs6505170^1,2	A,C	25643496(+)	`CCAAAA/CGGGAG`	1	--	ng3¹		0	--	--	--	--
	rs11653777^1,2	H	25599284(+)	`GAGCCA/CCCTGG`	1	--	ng5¹		4		EU EA WA	400
--	rs3830317^1,2	C	25599577(-)	`GGGTG-/TGCACAT`	1	--	ut3¹		0	--	--	--	--
--	rs3834977^1,2	C	25644103(-)	`CACAC-/ACTCAAC`	1	--	ng3¹		0	--	--	--	--
	rs7342921^1,2	A,C,F,H	25636574(+)	`CCTTTG/CGTTGC`	1	T/T	syn¹ ese³		12		NA EU EA WA	990
	rs3110098^1,2	A,C,F,H	25631337(+)	`TCTTCC/TGCTTA`	1	--	int¹		4		EU EA WA	418
	rs2129785^1,2	C,F,H,O	25614656(-)	`TACCAA/GCCTGG`	1	--	int¹		7		EU EA WA NA	562

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HapMap Linkage Disequilibrium images for BLMH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602403 disorders: 104300

7 Novoseek disease relationships for BLMH gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	51.62	10	9818937 (2), 10350576 (2), 10822352 (2), 10973933 (1) (see all 7)
senile plaques	28.46	2	10350576 (1), 11350084 (1)
neurodegenerative diseases	8.16	1	12604387 (1)
cancer	0.00	3	18398146 (1), 8063738 (1)
tumors	0.00	7	9331073 (2), 8620487 (2), 10404591 (1), 12555812 (1)
dementia	0.00	1	10530514 (1)
lymphoma	0.00	1	8620487 (1)

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Human Gene Mutation Database: BLMH
Genetic Association Database: BLMH
Human Genome Epidemiology Navigator: BLMH (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/59 PubMed articles for BLMH gene (see all 59 ):

Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. (PubMed id 8620487)^{1, 3, 4} Ferrando A.A.... Lopez-Otin C. (1996)
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. (PubMed id 15900213)^{1, 3, 6} Nuver J....Gietema J.A. (2005)
Crystal structure of human bleomycin hydrolase, a self- compartmentalizing cysteine protease. (PubMed id 10404591)^{1, 3, 4} O'Farrell P.A.... Joshua-Tor L. (1999)
Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. (PubMed id 8639621)^{1, 3, 4} Broemme D.... Payan D.G. (1996)
Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase. (PubMed id 9407121)^{1, 2, 3} Ferrando A.A....Lopez-Otin C. (1997)
Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase. (PubMed id 9331073)^{1, 2, 3} Montoya S.E....Lazo J.S. (1997)
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PubMed id 11436125)^{1, 3, 6} Prince J.A....Brookes A.J. (2001)
Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. (PubMed id 11099722)^{1, 3, 6} Hu C.J....Chang J.G. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity. (PubMed id 12082022)^{3, 6} Tuimala J....Norppa H. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 642	HGNC: 1059	AceView: BLMH	Ensembl:ENSG00000108578	euGenes: HUgn642
ECgene: BLMH	H-InvDB: BLMH

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for BLMH	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BLMH
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for BLMH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BLMH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BLMH		Antibodies for BLMH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BLMH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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BLMH Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for BLMH

Summaries
for BLMH

Genomic Location
for BLMH

Proteins
for BLMH

Protein Domains/
Families
for BLMH

Gene Function
for BLMH

Pathways & Interactions
for BLMH

Drugs & Compounds
for BLMH

Transcripts
for BLMH

Expression
for BLMH

Orthologs
for BLMH

Paralogs
for BLMH

SNPs/Variants
for BLMH

Disorders & Mutations
for BLMH

Medical News
for BLMH

Publications
for BLMH

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Genome Databases showing BLMH

Other Databases showing BLMH

Specialized Databases showing BLMH

Licensable Technologies
for BLMH

Services
for BLMH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BLMH Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor BLMH

Summariesfor BLMH

Genomic Locationfor BLMH

Proteinsfor BLMH

Protein Domains/Familiesfor BLMH

Gene Functionfor BLMH

Pathways & Interactionsfor BLMH

Drugs & Compoundsfor BLMH

Transcriptsfor BLMH

Expression for BLMH

Orthologsfor BLMH

Paralogsfor BLMH

SNPs/Variantsfor BLMH

Disorders & Mutationsfor BLMH

Medical Newsfor BLMH

Publicationsfor BLMH

Search for BLMH

Genome Databases showing BLMH

Other Databases showing BLMH

Specialized Databases showing BLMH

Licensable Technologiesfor BLMH

Servicesfor BLMH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BLMH

Summaries
for BLMH

Genomic Location
for BLMH

Proteins
for BLMH

Protein Domains/
Families
for BLMH

Gene Function
for BLMH

Pathways & Interactions
for BLMH

Drugs & Compounds
for BLMH

Transcripts
for BLMH

Expression
for BLMH

Orthologs
for BLMH

Paralogs
for BLMH

SNPs/Variants
for BLMH

Disorders & Mutations
for BLMH

Medical News
for BLMH

Publications
for BLMH

Licensable Technologies
for BLMH

Services
for BLMH