BLK Gene
protein-coding GIFtS: 72
GCID: GC08P011388
|
|
B lymphoid tyrosine kinase
| |
Aliases
for BLK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| B Lymphoid Tyrosine Kinase1 2 | | MODY112 5 | | B Lymphocyte Kinase2 3 | | MGC104421 | | P55-Blk1 | | BLK Nonreceptor Tyrosine Kinase2 | | EC 2.7.10.23 8 | | Tyrosine-Protein Kinase Blk2 |
| External Ids: | HGNC: 10571 | Entrez Gene: 6402 | Ensembl: ENSG000001365737 | OMIM: 1913055 | UniProtKB: P514513 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n341420 | |
Export aliases for BLK gene to outside databasesPrevious GC identifers: GC08P011414 GC08P011222 GC08P010282
Summaries
for BLK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BLK:
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved incell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development.The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression ofseveral pancreatic beta-cell transcription factors. (provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: BLK_HUMAN, P51451Function: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cellreceptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, andassociated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimatelyleads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surfaceimmunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosisdownstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79Bat 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN andLYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTKactivation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulatorof beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion inresponse to glucose
Gene Wiki entry for BLK (Tyrosine-protein kinase BLK)
|
Genomic Views
for BLK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_077531.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BLK gene promoter:
TBP Spz1 AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for BLK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23-p22 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23-p22BLK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P011388: view genomic region
(about GC identifiers)
Start:
|
11,351,510 bp from pter |
End:
|
11,422,113 bp from pter |
Size:
|
70,604 bases |
Orientation:
|
plus strand |
|
Proteins
for BLK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BLK_HUMAN, P51451 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Blk Size: 505 amino acids; 57706 Da
Subunit: Interacts with CBL (via SH2 domain). Interacts with CD79A and CD79B (via SH2 domain) (By similarity)
Subcellular location: Cell membrane; Lipid-anchor (By similarity). Note=Present and active in lipid rafts. Membranelocation is required for the phosphorylation of CD79A and CD79B (By similarity)
Secondary accessions: Q16291 Q96IN1Explore the universe of human proteins at neXtProt for BLK: NX_P51451
Post-translational modifications:
Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR) (Bysimilarity)1
Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by theubiquitin-proteasome pathway (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51451
4/15 DME Specific Peptides for BLK (P51451) (see all 15)
BLK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001706.2
ENSEMBL proteins: ENSP00000259089 ENSP00000433663 ENSP00000433150 Reactome Protein details: P51451
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- |
BLK for ontologies About GeneDecksing
BLK Antibody Products:
Assay Products for BLK: |
Protein
Domains /
Families
for BLK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BLK for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P51451ProtoNet protein and cluster: P51451 3 Blocks protein families: IPB000980 SH2 domain signature IPB001452 SH3 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: BLK_HUMAN, P51451Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for BLK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BLK_HUMAN, P51451Function: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cellreceptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, andassociated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimatelyleads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surfaceimmunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosisdownstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79Bat 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN andLYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTKactivation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulatorof beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion inresponse to glucoseCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in thephosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity (By similarity)Induction: Expression is under the control of NF-kappa-B as well as the B-cell specific transcription factors PAX5 andEBF1 Genatlas biochemistry entry for BLK:lymphoid non receptor tyrosine kinase (58kDa),homologous to mouse Blk,SRC family
Enzyme Number (IUBMB): EC 2.7.10.21 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BLK (NM_001715) | |  | Sino Biological Human cDNA Clone for BLK | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BLK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLK |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
BLK for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for BLK:
Animal Models:
Mouse knock-out Blktm1Tara for BLK
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Blk):
BLK for phenotypes About GeneDecksing
|
Pathways & Interactions
for BLK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Assembly of Signalosomes at the Activated BCR | | | 3 | Tyrosine Kinases / Adaptors | | | 4 | Lymphocyte Signaling | | | 5 | Signaling by the B Cell Receptor (BCR) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BLK
2 
Cell Signaling Technology (CST) Pathways for BLK
5/15  BioSystems Pathways for BLK (see all 15)
5 
Reactome Pathways for BLK
BLK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BLK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/70 Interacting proteins for BLK (P514512, 3 ENSP000002590894) via UniProtKB, MINT, STRING, and/or I2D (see all 70)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
BLK for ontologies About GeneDecksing
|
Drugs & Compounds
for BLK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BLK for compounds About GeneDecksing
 Browse Tocris compounds for BLK
2 HMDB Compounds for BLK About this table
6 Novoseek chemical compound relationships for BLK gene About this table
Search CenterWatch for drugs/clinical trials and news about BLK
|
Transcripts
for BLK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BLK gene: NM_001715.2 Unigene Cluster for BLK: B lymphoid tyrosine kinase Hs.146591 [show with all ESTs]Unigene Representative Sequence: AK1313197 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000259089(uc003wty.3) ENST00000525389(uc003wtx.3) ENST00000529894
ENST00000533828 ENST00000526778 ENST00000525206 ENST00000526097(uc003wua.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BLK (NM_001715) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BLK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLK |
Additional cDNA sequence: AK131319.1 AK313751.1 AL832875.1 BC004473.2 BC007371.2 BC018703.1 BC032413.1 BC038555.1 S76617.1 Z33998.1 10 DOTS entries: DT.453246 DT.100019437 DT.91707407 DT.91750791 DT.120648337 DT.40106270 DT.40310138 DT.95163770 DT.75131135 DT.91707406 24/83 AceView cDNA sequences (see all 83): NM_001715 BM465722 CR625422 BC018703 BI224882 AL832875 BC007371 BI521453 BC032413 BI908955 AW406482 BP340291 BM458538 AU158887 AU141286 BI521532 BQ708155 BG340510 BQ049022 BM465077 BG388319 BC004473 BG177324 BQ066207
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BLK (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BLK
|
Expression
for BLK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BLK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGCGCCCCG
About this image
See BLK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BLK
SOURCE GeneReport for Unigene cluster: Hs.146591
UniProtKB/Swiss-Prot: BLK_HUMAN, P51451Tissue specificity: Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glandsand hair follicles
SABiosciences Custom PCR Arrays for BLK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BLK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLK |
Orthologs
for BLK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BLK gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BLK1 |
B lymphoid tyrosine kinase |
73.45(n)
75.57(a) |
|
422035 XM_420040.3 XP_420040.3 |
lizard
(Anolis carolinensis) |
Reptilia |
BLK6 |
-- |
69(a) |
1 ↔ 1 |
GL343551.1(369677-391009) |
zebrafish
(Danio rerio) |
Actinopterygii |
blk1 |
B lymphoid tyrosine kinase |
67.32(n)
69.13(a) |
|
567764 NM_001030220.1 NP_001025391.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Src64B3 |
ring canal formation protein tyrosine kinase |
51(a) |
|
64B12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
src-13 |
Expression: vulva, anus, mu_bod, pharyngeal
muscle, more |
43(a)
(best of 3) |
|
I(1567610-1580076) -- |
ENSEMBL Gene Tree for BLK (if available)
TreeFam Gene Tree for BLK (if available) |
Paralogs
for BLK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BLK gene
- TEC2 FRK2 LCK2 FGR2 ITK2 LYN2 TXK2 HCK2
- YES12 PTK62 SRC2 ABL12 FYN2 BMX2 ABL22 SRMS2
- BTK2
18/73 SIMAP similar genes for BLK using alignment to 4 protein entries: BLK_HUMAN (see all proteins)
(see all similar genes):LYN YES1 c-fgr LCK HCK FGR
FYN SRC NCK2 ABL1 FRK BRAF
DKFZp686M05208 GRAP2 tec TEC FLT4 SLA2
BLK for paralogs About GeneDecksing
|
Genomic Variants
for BLK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BLK (11351510 - 11422113 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for BLK
3 CNVs: 6592 47971 53411
15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306
Human Gene Mutation Database (HGMD): BLK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BLK |
|
Disorders
/ Diseases
for BLK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BLK for disorders About GeneDecksing
OMIM gene information: 191305
OMIM disorders: 613375
UniProtKB/Swiss-Prot: BLK_HUMAN, P51451
Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) [MIM:613375]. MODY11 is aform of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or earlyadulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence atthe beginning of the disease
17  diseases for BLK: About MalaCardsmaturity-onset diabetes of the young, type 11 maturity-onset diabetes of the young keratolytic winter erythema pancreatitis
sle susceptibility lupus erythematosus b-cell lymphomas systemic lupus erythematosus
systemic scleroderma antiphospholipid syndrome ulcerative colitis cutaneous t cell lymphoma
rheumatoid arthritis scleroderma arthritis pharyngitis
leukemia
1 disease from the University of Copenhagen DISEASES database for BLK:Systemic lupus erythematosus 3 Novoseek disease relationships for BLK gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lupus erythematosus systemic |
33.6 |
2 |
19180478 (1) |
| lymphoma |
14.1 |
2 |
8349295 (1), 19351960 (1) |
| necrosis |
0 |
1 |
16907856 (1) |
Human Genome Epidemiology (HuGE) Navigator: BLK (20 documents)
Tumor Gene Database (TGDB): BLK
Export disorders for BLK gene to outside databases
|
Publications
for BLK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BLK gene, integrated from 9 sources (see all 94):
(articles sorted by number of sources associating them with BLK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). (PubMed id 7845672)1, 2, 3, 9 Drebin J.A....Niederhuber J.E. (1995)
- Mutations at the BLK locus linked to maturity onset d iabetes of the young and beta-cell dysfunction. (PubMed id 19667185)1, 2, 9 Borowiec M....Doria A. (2009)
- In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. (PubMed id 8756631)1, 2, 9 Bewarder N....Frey J. (1996)
- Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk. (PubMed id 7822795)1, 2, 9 Islam K.B.... Smith C.I. (1995)
- The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. (PubMed id 8083187)1, 2 Donovan J.A....Samelson L.E. (1994)
- Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma. (PubMed id 19351960)1, 9 Krejsgaard T....A9dum N. (2009)
- Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. (PubMed id 9525867)1, 9 Hegde R....Alnemri E.S. (1998)
- Reconstitution of the B cell antigen receptor signaling components in COS cells. (PubMed id 7592958)1, 9 Saouaf S.J....Mahajan S. (1995)
- Transcription of the blk gene in human B lymphocytes is controlled by two promoters. (PubMed id 7592787)1, 9 Lin Y.H....Niederhuber J.E. (1995)
- Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. (PubMed id 14970218)1, 9 Cho J.-Y.... Libermann T.A. (2004)
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External Searches for BLK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing BLK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing BLK gene
(According to HUGE)
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| -- |
Specialized Databases showing BLK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for BLK gene:
Search GeneIP for patents involving BLK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for BLK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for BLK | | OriGene shRNA RFP for BLK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BLK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BLK | | OriGene 3'-UTR Clone for BLK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BLK | | OriGene Custom Protein Services for BLK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BLK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BLK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BLK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLK |
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| | Antibodies & Assays for BLK |
| | | | Search Tocris compounds for BLK |
| |  |  |  |  | | | | | | Recombinant Protein for BLK |
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 | | | BLK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLK |
|  |  |  | | | | ThermoFisher Antibody for BLK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLK |
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