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Aliases for BLID Gene

Aliases for BLID Gene

  • BH3-Like Motif Containing, Cell Death Inducer 2 3
  • Breast Cancer Cell Protein 2 3 4
  • Breast Cancer Cell 2 2 3
  • BRCC2 3 4
  • BH3-Like Motif-Containing Cell Death Inducer 3
  • BRCC@ 6

External Ids for BLID Gene

Previous GeneCards Identifiers for BLID Gene

  • GC11M121492
  • GC11M121986
  • GC11M117932

Summaries for BLID Gene

Entrez Gene Summary for BLID Gene

  • This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011]

GeneCards Summary for BLID Gene

BLID (BH3-Like Motif Containing, Cell Death Inducer) is a Protein Coding gene. Diseases associated with BLID include breast cancer and alzheimer disease.

UniProtKB/Swiss-Prot for BLID Gene

  • Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLID Gene

Genomics for BLID Gene

Regulatory Elements for BLID Gene

Genomic Location for BLID Gene

Start:
122,115,354 bp from pter
End:
122,116,215 bp from pter
Size:
862 bases
Orientation:
Minus strand

Genomic View for BLID Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BLID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLID Gene

Proteins for BLID Gene

  • Protein details for BLID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZY5-BLID_HUMAN
    Recommended name:
    BH3-like motif-containing cell death inducer
    Protein Accession:
    Q8IZY5
    Secondary Accessions:
    • A1L416

    Protein attributes for BLID Gene

    Size:
    108 amino acids
    Molecular mass:
    12045 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BLID Gene

Proteomics data for BLID Gene at MOPED

Post-translational modifications for BLID Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BLID Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BLID Gene

Domains for BLID Gene

Protein Domains for BLID Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BLID Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLID: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BLID Gene

Function for BLID Gene

Molecular function for BLID Gene

UniProtKB/Swiss-Prot Function: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BLID Gene

Localization for BLID Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLID Gene

Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BLID Gene COMPARTMENTS Subcellular localization image for BLID gene
Compartment Confidence
mitochondrion 5
cytosol 2
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BLID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with BLID: view

Pathways for BLID Gene

SuperPathways for BLID Gene

No Data Available

Interacting Proteins for BLID Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000453153%0d%0a9606.ENSP00000329623%0d%0a9606.ENSP00000302564%0d%0a
Selected Interacting proteins: ENSP00000453153 Q8IZY5-BLID_HUMAN for BLID Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BLID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BLID: view

No data available for Pathways by source for BLID Gene

Transcripts for BLID Gene

mRNA/cDNA for BLID Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BLID Gene

No ASD Table

Relevant External Links for BLID Gene

GeneLoc Exon Structure for
BLID
ECgene alternative splicing isoforms for
BLID

Expression for BLID Gene

mRNA expression in normal human tissues for BLID Gene

mRNA differential expression in normal tissues according to GTEx for BLID Gene

This gene is overexpressed in Artery - Aorta (5.4), Ovary (4.2), and Heart - Atrial Appendage (4.1).

SOURCE GeneReport for Unigene cluster for BLID Gene Hs.686109

mRNA Expression by UniProt/SwissProt for BLID Gene

Q8IZY5-BLID_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with BLID: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for BLID Gene

Orthologs for BLID Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BLID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLID 35
  • 98.46 (n)
  • 95.33 (a)
Species with no ortholog for BLID:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BLID Gene

ENSEMBL:
Gene Tree for BLID (if available)
TreeFam:
Gene Tree for BLID (if available)

Paralogs for BLID Gene

No data available for Paralogs for BLID Gene

Variants for BLID Gene

Sequence variations from dbSNP and Humsavar for BLID Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_056750 -

Structural Variations from Database of Genomic Variants (DGV) for BLID Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV Gain 17160897
nsv898430 CNV Gain 21882294

Relevant External Links for BLID Gene

HapMap Linkage Disequilibrium report
BLID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLID Gene

Disorders for BLID Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BLID Gene including...

Search for BLID Gene in MalaCards »

Relevant External Links for BLID

Genetic Association Database (GAD)
BLID
Human Genome Epidemiology (HuGE) Navigator
BLID
genes like me logo Genes that share disorders with BLID: view

No data available for UniProtKB/Swiss-Prot for BLID Gene

Publications for BLID Gene

  1. BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. (PMID: 15069058) Broustas C.G. … Kasid U. (J. Biol. Chem. 2004) 2 3 4 23
  2. A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1. (PMID: 19779542) Nakanishi H. … Matsuda F. (PLoS Genet. 2009) 3 48
  3. The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and overall survival. (PMID: 20400521) Broustas C.G. … Kasid U.N. (Clin. Cancer Res. 2010) 3
  4. MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia. (PMID: 20544842) Tassano E. … Morerio C. (Genes Chromosomes Cancer 2010) 3
  5. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PMID: 20838585) Smith E.N. … Murray S.S. (PLoS Genet. 2010) 3

Products for BLID Gene

Sources for BLID Gene

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