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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BLID Gene

protein-coding   GIFtS: 39
GCID: GC11M121986

BH3-Like Motif Containing, Cell Death Inducer

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BH3-Like Motif Containing, Cell Death Inducer1 2
Breast Cancer Cell 21 2
Breast Cancer Cell Protein 22 3
BRCC22 3
BH3-Like Motif-Containing Cell Death Inducer2
BRCC@5

External Ids:    HGNC: 334951   Entrez Gene: 4148992   Ensembl: ENSG000002595717   OMIM: 6088535   UniProtKB: Q8IZY53   

Export aliases for BLID gene to outside databases

Previous GC identifers: GC11M121492 GC11M117932


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BLID Gene:
This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce
apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion.
(provided by RefSeq, Aug 2011)

GeneCards Summary for BLID Gene: 
BLID (BH3-like motif containing, cell death inducer) is a protein-coding gene. Diseases associated with BLID include degenerative myopia, and breast cancer.

UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5
Function: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BLID gene promoter:
         RFX1   AML1a   HSF1 (long)   XBP-1   Gfi-1   Nkx6-1   POU2F1   POU2F1a   IRF-7A   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBLID promoter sequence
   Search SABiosciences Chromatin IP Primers for BLID

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLID


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

BLID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BLID gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M121986:  view genomic region     (about GC identifiers)

Start:
121,986,062 bp from pter      End:
121,986,923 bp from pter
Size:
862 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5 (See protein sequence)
Recommended Name: BH3-like motif-containing cell death inducer  
Size: 108 amino acids; 12045 Da
Subcellular location: Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm
Secondary accessions: A1L416

Explore the universe of human proteins at neXtProt for BLID: NX_Q8IZY5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZY5

  • BLID Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001001786.2  
    ENSEMBL proteins: 
     ENSP00000453153  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    BLID for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IZY5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BLID_HUMAN, Q8IZY5
    Function: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BLID

    2 Interacting proteins for BLID (Q8IZY53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104153I2D: score=1 
    BCL2L1Q078173I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    BLID for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BLID

    Search CenterWatch for drugs/clinical trials and news about BLID

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for BLID gene: 
    NM_001001786.2  

    Unigene Cluster for BLID:

    BH3-like motif containing, cell death inducer
    Hs.686109
    Unigene Representative Sequence: NM_001001786
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000560104(uc001pyf.3)

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    Inhib. RNA
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    Additional mRNA sequence: 

    AF303179.1 BC130361.1 BC130363.1 

    1 DOTS entry:

    DT.95224034 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BLID expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTCAGAG
    BLID Expression
    About this image


    Genevestigator expression for BLID

    SOURCE GeneReport for Unigene cluster: Hs.686109

    UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for BLID
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLID

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for BLID (if available)
    TreeFam Gene Tree for BLID (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in BLID are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0567504
    ----see VAR_0567502 A D mis40--------

    HapMap Linkage Disequilibrium report for BLID (121986062 - 121986923 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BLID:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898430CNV Gain21882294
    dgv17n68CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608853    OMIM disorders: --

    5 diseases for BLID:    About MalaCards
    degenerative myopia    breast cancer    myopia    alzheimer's disease
    neuronitis


    BLID for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): BLID
    Human Genome Epidemiology (HuGE) Navigator: BLID (2 documents)

    Export disorders for BLID gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BLID gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with BLID)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. (PubMed id 15069058)1, 2, 3, 9 Broustas C.G....Kasid U. (2004)
    2. A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1. (PubMed id 19779542)1, 4 Nakanishi H....Matsuda F. (2009)
    3. Frequent loss of the BLID gene in early-onset breast cancer. (PubMed id 21846966)1 Cavalli L.R....Haddad B.R. (2011)
    4. MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leu kemia. (PubMed id 20544842)1 Tassano E....Morerio C. (2010)
    5. Longitudinal genome-wide association of cardiovascula r disease risk factors in the bogalusa heart study. (PubMed id 20838585)1 Smith E.N....Murray S.S. (2010)
    6. Evaluation of BLID and LOC399959 as candidate genes f or high myopia in the Chinese Han population. (PubMed id 21031016)1 Zhao F....Zhou X. (2010)
    7. The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and o verall survival. (PubMed id 20400521)1 Broustas C.G....Kasid U.N. (2010)
    8. Assignment of the BLID gene to 11q24.1 by fluorescence in situ hybridization. (PubMed id 18940476)1 Cavalli L.R....Haddad B.R. (2008)
    9. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PubMed id 17903304)4 Larson M.G....Levy D. (2007)
    10. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 414899 HGNC: 33495 Ensembl:ENSG00000259571 euGenes: HUgn414899 ECgene: BLID
    H-InvDB: BLID

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BLID Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BLID gene:
    Search GeneIP for patents involving BLID

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for BLID
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BLID
    Customized:
     lentivirus for stable overexpression of BLID
     lentivirus expression plasmids for stable overexpression of BLID
     adenovirus for overexpression of BLID
     Search LSBio for Antibodies for BLID
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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