Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BLID Gene

Aliases for BLID Gene

  • BH3-Like Motif Containing, Cell Death Inducer 2 3 5
  • Breast Cancer Cell Protein 2 3 4
  • Breast Cancer Cell 2 2 3
  • BRCC2 3 4
  • BH3-Like Motif-Containing Cell Death Inducer 3

External Ids for BLID Gene

Previous GeneCards Identifiers for BLID Gene

  • GC11M121492
  • GC11M121986
  • GC11M117932

Summaries for BLID Gene

Entrez Gene Summary for BLID Gene

  • This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011]

GeneCards Summary for BLID Gene

BLID (BH3-Like Motif Containing, Cell Death Inducer) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BLID Gene

  • Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLID Gene

Genomics for BLID Gene

Regulatory Elements for BLID Gene

Enhancers for BLID Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G122174 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -62.6 -62579 8.4 TAF1 SIN3A ZNF316 GATA2 POLR2A SCRT2 FOS NFE2 MAFK TCF7L2 BLID MIR100HG ENSG00000255219 GC11P122184 GC11M122156 GC11M122154 MIR100
GH11G122185 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -76.0 -76010 13.3 GTF2F1 TBP FOXA2 TAF1 JUN MAX SIN3A CHD4 RAD21 RFX5 MIRLET7A2 BLID MIR100HG ENSG00000255219 GC11M122182 GC11P122184
GH11G122043 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +70.4 70415 3.6 JUND GATA2 JUN FOS MAFK BLID MIR100HG MIR125B1 GC11P122016 GC11P122071
GH11G122135 1.3 Ensembl ENCODE dbSUPER 11.9 -22.7 -22662 7.3 JUN SIN3A BRCA1 YY1 ETS1 GATA3 GATA2 POLR2A RERE HNF4G BLID MIR100HG MIRLET7A2 GC11P122118
GH11G122153 1.2 Ensembl ENCODE dbSUPER 11.2 -46.3 -46313 18.5 CTCF JUN ZSCAN4 RAD21 POLR2A FOS MAFK TCF7L2 BHLHE40 CHD1 BLID MIR100HG ENSG00000255015 UBASH3B GC11M122156 MIR100 GC11M122154 GC11P122184
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BLID on UCSC Golden Path with GeneCards custom track

Genomic Location for BLID Gene

Chromosome:
11
Start:
122,115,354 bp from pter
End:
122,116,215 bp from pter
Size:
862 bases
Orientation:
Minus strand

Genomic View for BLID Gene

Genes around BLID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLID Gene

Proteins for BLID Gene

  • Protein details for BLID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZY5-BLID_HUMAN
    Recommended name:
    BH3-like motif-containing cell death inducer
    Protein Accession:
    Q8IZY5
    Secondary Accessions:
    • A1L416

    Protein attributes for BLID Gene

    Size:
    108 amino acids
    Molecular mass:
    12045 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BLID Gene

Post-translational modifications for BLID Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BLID Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BLID Gene

Domains & Families for BLID Gene

Protein Domains for BLID Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BLID Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLID: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BLID Gene

Function for BLID Gene

Molecular function for BLID Gene

UniProtKB/Swiss-Prot Function:
Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.
genes like me logo Genes that share phenotypes with BLID: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BLID Gene

Localization for BLID Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLID Gene

Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLID gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for BLID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with BLID: view

Pathways & Interactions for BLID Gene

No Data Available

Interacting Proteins for BLID Gene

Gene Ontology (GO) - Biological Process for BLID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BLID: view

No data available for Pathways by source and SIGNOR curated interactions for BLID Gene

Drugs & Compounds for BLID Gene

No Compound Related Data Available

Transcripts for BLID Gene

mRNA/cDNA for BLID Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLID Gene

No ASD Table

Relevant External Links for BLID Gene

GeneLoc Exon Structure for
BLID
ECgene alternative splicing isoforms for
BLID

Expression for BLID Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLID Gene

mRNA differential expression in normal tissues according to GTEx for BLID Gene

This gene is overexpressed in Artery - Aorta (x5.4), Ovary (x4.2), and Heart - Atrial Appendage (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of BLID Gene:

BLID

SOURCE GeneReport for Unigene cluster for BLID Gene:

Hs.686109

mRNA Expression by UniProt/SwissProt for BLID Gene:

Q8IZY5-BLID_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with BLID: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLID Gene

Orthologs for BLID Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BLID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLID 34
  • 98.46 (n)
Species where no ortholog for BLID was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BLID Gene

ENSEMBL:
Gene Tree for BLID (if available)
TreeFam:
Gene Tree for BLID (if available)

Paralogs for BLID Gene

No data available for Paralogs for BLID Gene

Variants for BLID Gene

Sequence variations from dbSNP and Humsavar for BLID Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000025309 -- 122,115,068(+) AAGAC(A/G)CCTAG intron-variant, downstream-variant-500B
rs1000286406 -- 122,115,294(+) GGACA(C/G)TGGCA intron-variant, downstream-variant-500B
rs1000620569 -- 122,116,864(+) AATCA(C/T)GGGCA intron-variant, upstream-variant-2KB
rs1002623384 -- 122,117,976(+) AGAAA(A/G)CTAGA intron-variant, upstream-variant-2KB
rs1003080536 -- 122,117,399(+) AAGTA(G/T)CCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BLID Gene

Variant ID Type Subtype PubMed ID
dgv17n68 CNV gain 17160897

Variation tolerance for BLID Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BLID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLID Gene

Disorders for BLID Gene

Relevant External Links for BLID

Genetic Association Database (GAD)
BLID
Human Genome Epidemiology (HuGE) Navigator
BLID
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BLID

No disorders were found for BLID Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BLID Gene

Publications for BLID Gene

  1. BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. (PMID: 15069058) Broustas C.G. … Kasid U. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1. (PMID: 19779542) Nakanishi H. … Matsuda F. (PLoS Genet. 2009) 3 46 64
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3 64
  4. MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells. (PMID: 25728273) Wang H. … Shao Y. (FEBS Lett. 2015) 3 64
  5. Aberrant BLID expression is associated with breast cancer progression. (PMID: 24532431) Li X. … Yang Q. (Tumour Biol. 2014) 3 64

Products for BLID Gene

Sources for BLID Gene

Content
Loading form....