BLID Gene
protein-coding GIFtS: 36
GCID: GC11M121986
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BH3-like motif containing, cell death inducer
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Aliases
for BLID gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BH3-Like Motif Containing, Cell Death Inducer1 2 | | BRCC21 2 3 | | Breast Cancer Cell Protein 22 3 | | BH3-Like Motif-Containing Cell Death Inducer2 | | Breast Cancer Cell 22 | | BRCC@5 |
Export aliases for BLID gene to outside databasesPrevious GC identifers: GC11M121492 GC11M117932 |
Summaries
for BLID gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BLID:
This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosisin a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. (provided byRefSeq, Aug 2011)
UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5Function: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death
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Genomic Views
for BLID gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BLID gene promoter:
RFX1 AML1a HSF1 (long) XBP-1 Gfi-1 Nkx6-1 POU2F1 POU2F1a IRF-7A MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for BLID
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLID |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24.1BLID Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M121986: view genomic region
(about GC identifiers)
Start:
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121,986,062 bp from pter |
End:
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121,986,923 bp from pter |
Size:
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862 bases |
Orientation:
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minus strand |
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Proteins
for BLID gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5 (See
protein sequence)Recommended Name: BH3-like motif-containing cell death inducer Size: 108 amino acids; 12045 Da
Subcellular location: Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm
Secondary accessions: A1L416Explore the universe of human proteins at neXtProt for BLID: NX_Q8IZY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZY5
BLID Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001001786.2
ENSEMBL proteins: ENSP00000453153
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
BLID for ontologies About GeneDecksing
BLID Antibody Products:
Assay Products for BLID: |
Protein
Domains /
Families
for BLID gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IZY5 |
Function
for BLID gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5Function: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLID
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLID
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BLID (NM_001001786) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BLID | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLID |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLID |
|
Pathways & Interactions
for BLID gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BLID
2 Interacting proteins for BLID (Q8IZY53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IEA | -- |
BLID for ontologies About GeneDecksing
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Drugs & Compounds
for BLID gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BLID
Search CenterWatch for drugs/clinical trials and news about BLID
|
Transcripts
for BLID gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BLID gene: NM_001001786.2 Unigene Cluster for BLID: BH3-like motif containing, cell death inducer Hs.686109 Unigene Representative Sequence: NM_0010017861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000560104(uc001pyf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLID
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLID
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BLID (NM_001001786) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BLID | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLID |
Additional cDNA sequence: AF303179.1 BC130361.1 BC130363.1 1 DOTS entry: DT.95224034
GeneLoc Exon Structure
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Expression
for BLID gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BLID expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTTCAGAG
About this image
Genevestigator expression for BLID
SOURCE GeneReport for Unigene cluster: Hs.686109
UniProtKB/Swiss-Prot: BLID_HUMAN, Q8IZY5Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for BLID
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLID
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BLID | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLID | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLID | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLID |
Orthologs
for BLID gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for BLID (if available)
TreeFam Gene Tree for BLID (if available) |
Paralogs
for BLID gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BLID gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BLID (121986062 - 121986923 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BLID: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for BLID gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BLID for disorders About GeneDecksing
OMIM gene information: 608853
OMIM disorders: --
6  diseases for BLID: About MalaCardsbreast cancer degenerative myopia myopia 11 myopia
alzheimer's disease neuronitis
Human Genome Epidemiology (HuGE) Navigator: BLID (2 documents)
Export disorders for BLID gene to outside databases
|
Publications
for BLID gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BLID gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with BLID) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. (PubMed id 15069058)1, 2, 3, 9 Broustas C.G....Kasid U. (2004)
- Frequent loss of the BLID gene in early-onset breast cancer. (PubMed id 21846966)1 Cavalli L.R....Haddad B.R. (2011)
- MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leu kemia. (PubMed id 20544842)1 Tassano E....Morerio C. (2010)
- Longitudinal genome-wide association of cardiovascula r disease risk factors in the bogalusa heart study. (PubMed id 20838585)1 Smith E.N....Murray S.S. (2010)
- Evaluation of BLID and LOC399959 as candidate genes f or high myopia in the Chinese Han population. (PubMed id 21031016)1 Zhao F....Zhou X. (2010)
- The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and o verall survival. (PubMed id 20400521)1 Broustas C.G....Kasid U.N. (2010)
- A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1. (PubMed id 19779542)1 Nakanishi H....Matsuda F. (2009)
- Assignment of the BLID gene to 11q24.1 by fluorescence in situ hybridization. (PubMed id 18940476)1 Cavalli L.R....Haddad B.R. (2008)
- The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. (PubMed id 17220890)3 Rogaeva E....St George-Hyslop P. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for BLID gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BLID gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BLID gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BLID gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BLID | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BLID gene:
Search GeneIP for patents involving BLID
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BLID gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BLID | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BLID | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BLID | | | OriGene Protein Over-expression Lysate for BLID | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BLID | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BLID | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BLID | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BLID | | OriGene Custom Protein Services for BLID | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BLID | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BLID | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BLID | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BLID | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BLID | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BLID |
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 | | | BLID Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BLID |
|  |  |  | | | | Search ThermoFisher Antibodies for BLID |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BLID |
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