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Aliases for BLCAP Gene

Aliases for BLCAP Gene

  • Bladder Cancer Associated Protein 2 3 5
  • BC10 3 4
  • Bladder Cancer Related Protein (10kD) 3
  • Bladder Cancer-Associated Protein 3
  • Bladder Cancer 10 KDa Protein 4

External Ids for BLCAP Gene

Previous GeneCards Identifiers for BLCAP Gene

  • GC20M035874
  • GC20M036784
  • GC20M036831
  • GC20M035579
  • GC20M036130
  • GC20M032881

Summaries for BLCAP Gene

Entrez Gene Summary for BLCAP Gene

  • This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]

GeneCards Summary for BLCAP Gene

BLCAP (Bladder Cancer Associated Protein) is a Protein Coding gene. Diseases associated with BLCAP include Bladder Cancer, Somatic.

UniProtKB/Swiss-Prot for BLCAP Gene

  • May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Wiki entry for BLCAP Gene

Additional gene information for BLCAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLCAP Gene

Genomics for BLCAP Gene

Regulatory Elements for BLCAP Gene

Enhancers for BLCAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H037516 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +5.3 5326 13 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 RALGAPB RBL1 TTI1 LINC00489 ENSG00000201811 SNHG17 SOGA1 LOC100419562 SNORA71C MROH8
GH20H036830 2 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +694.1 694113 7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF143 FOS SP3 REST NDRG3 BLCAP RBL1 DSN1 SOGA1 GC20P036795
GH20H037534 1.1 Ensembl ENCODE 7.6 -6.8 -6815 0 HDGF PKNOX1 RB1 MLX ARID4B ZSCAN9 RAD21 RFX5 ZNF143 ATF7 BLCAP PPIAP3 LINC01746
GH20H037539 0.9 ENCODE 8.3 -13.5 -13457 2 ATF1 FOXA2 MLX DMAP1 ZNF766 GATA2 ELK1 CAVIN1 ZNF592 MEF2D SNHG17 RALGAPB SNORA71C GHRH MROH8 RPN2 RBL1 TTI1 BLCAP PPIAP3
GH20H036841 1.5 Ensembl ENCODE dbSUPER 4.6 +682.1 682131 9 ZNF121 GLIS2 ZNF207 FOS ATF7 RUNX3 JUNB ZNF518A ZNF592 GLIS1 NDRG3 DSN1 BLCAP SOGA1 GC20P036795
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BLCAP on UCSC Golden Path with GeneCards custom track

Promoters for BLCAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136853 531 2401 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207

Genomic Location for BLCAP Gene

Chromosome:
20
Start:
37,492,472 bp from pter
End:
37,527,931 bp from pter
Size:
35,460 bases
Orientation:
Minus strand

Genomic View for BLCAP Gene

Genes around BLCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLCAP Gene

Proteins for BLCAP Gene

  • Protein details for BLCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62952-BLCAP_HUMAN
    Recommended name:
    Bladder cancer-associated protein
    Protein Accession:
    P62952
    Secondary Accessions:
    • A2A2K7
    • O60629
    • Q9D3B5

    Protein attributes for BLCAP Gene

    Size:
    87 amino acids
    Molecular mass:
    9876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BLCAP Gene

Post-translational modifications for BLCAP Gene

No Post-translational modifications

No data available for DME Specific Peptides for BLCAP Gene

Domains & Families for BLCAP Gene

Gene Families for BLCAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BLCAP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BLCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62952

UniProtKB/Swiss-Prot:

BLCAP_HUMAN :
  • Belongs to the BLCAP family.
Family:
  • Belongs to the BLCAP family.
genes like me logo Genes that share domains with BLCAP: view

Function for BLCAP Gene

Molecular function for BLCAP Gene

UniProtKB/Swiss-Prot Function:
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Ontology (GO) - Molecular Function for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with BLCAP: view

Phenotypes for BLCAP Gene

genes like me logo Genes that share phenotypes with BLCAP: view

Animal Model Products

CRISPR Products

miRNA for BLCAP Gene

miRTarBase miRNAs that target BLCAP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BLCAP Gene

Localization for BLCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLCAP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLCAP gene
Compartment Confidence
extracellular 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BLCAP: view

Pathways & Interactions for BLCAP Gene

SuperPathways for BLCAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0030262 apoptotic nuclear changes IDA 17031575
genes like me logo Genes that share ontologies with BLCAP: view

No data available for Pathways by source and SIGNOR curated interactions for BLCAP Gene

Drugs & Compounds for BLCAP Gene

No Compound Related Data Available

Transcripts for BLCAP Gene

Unigene Clusters for BLCAP Gene

Bladder cancer associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLCAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - - - - -
SP4: - - -
SP5: - -

Relevant External Links for BLCAP Gene

GeneLoc Exon Structure for
BLCAP
ECgene alternative splicing isoforms for
BLCAP

Expression for BLCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLCAP Gene

mRNA differential expression in normal tissues according to GTEx for BLCAP Gene

This gene is overexpressed in Muscle - Skeletal (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of BLCAP Gene:

BLCAP

SOURCE GeneReport for Unigene cluster for BLCAP Gene:

Hs.472651

mRNA Expression by UniProt/SwissProt for BLCAP Gene:

P62952-BLCAP_HUMAN
Tissue specificity: Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.

Evidence on tissue expression from TISSUES for BLCAP Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Intestine(4.4)
  • Kidney(2.5)
  • Muscle(2.5)
  • Pancreas(2.3)
  • Eye(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with BLCAP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLCAP Gene

Orthologs for BLCAP Gene

This gene was present in the common ancestor of animals.

Orthologs for BLCAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLCAP 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia BLCAP 33 34
  • 97.7 (n)
dog
(Canis familiaris)
Mammalia BLCAP 33 34
  • 96.55 (n)
mouse
(Mus musculus)
Mammalia Blcap 33 16 34
  • 95.02 (n)
oppossum
(Monodelphis domestica)
Mammalia BLCAP 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Blcap 33
  • 93.49 (n)
chicken
(Gallus gallus)
Aves BLCAP 33 34
  • 86.59 (n)
lizard
(Anolis carolinensis)
Reptilia BLCAP 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia blcap 33
  • 78.16 (n)
Str.634 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12525 33
zebrafish
(Danio rerio)
Actinopterygii blcap 33 34
  • 84.29 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5031 33
fruit fly
(Drosophila melanogaster)
Insecta bc10 34
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.6 34
  • 40 (a)
OneToOne
Species where no ortholog for BLCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BLCAP Gene

ENSEMBL:
Gene Tree for BLCAP (if available)
TreeFam:
Gene Tree for BLCAP (if available)

Paralogs for BLCAP Gene

No data available for Paralogs for BLCAP Gene

Variants for BLCAP Gene

Sequence variations from dbSNP and Humsavar for BLCAP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000075729 -- 37,519,405(+) CAGAC(-/AAAAAAAAAAAAAAAAAAAG)AAAAA intron-variant, upstream-variant-2KB
rs1000243615 -- 37,524,736(+) TTAAG(C/T)TTCTT intron-variant, upstream-variant-2KB
rs1000860076 -- 37,523,589(+) GTAAG(C/T)TCCTG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000939691 -- 37,526,451(+) CCCTC(A/C)CCGAC intron-variant, upstream-variant-2KB
rs1000985219 -- 37,529,208(+) AGGGT(A/G)AAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BLCAP Gene

Variant ID Type Subtype PubMed ID
nsv1055206 CNV loss 25217958
nsv585962 CNV loss 21841781
nsv833968 CNV gain 17160897

Variation tolerance for BLCAP Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BLCAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLCAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLCAP Gene

Disorders for BLCAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for BLCAP Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
bladder cancer, somatic
  • bladder carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search BLCAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for BLCAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BLCAP
genes like me logo Genes that share disorders with BLCAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BLCAP Gene

Publications for BLCAP Gene

  1. Human BLCAP transcript: new editing events in normal and cancerous tissues. (PMID: 19908260) Galeano F … Gallo A (International journal of cancer 2010) 3 4 22 60
  2. Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma : BLCAP overexpression induces S phase arrest and apoptosis. (PMID: 17031575) Yao J … Wu X (Molecular and cellular biochemistry 2007) 2 3 4 60
  3. Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma. (PMID: 16675915) Zuo Z … Wu X (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2006) 3 4 22 60
  4. Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure. (PMID: 10197429) Gromova I … Celis JE (Electrophoresis 1999) 2 3 4 60
  5. BLCAP arrests G₁/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells. (PMID: 26986503) Zhao M … Wu X (Oncology reports 2016) 2 3 60

Products for BLCAP Gene

Sources for BLCAP Gene

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