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Aliases for BLCAP Gene

Aliases for BLCAP Gene

  • Bladder Cancer Associated Protein 2 3
  • BC10 3 4 6
  • Bladder Cancer 10 KDa Protein 3 4
  • Bladder Cancer Related Protein (10kD) 3
  • Bladder Cancer-Associated Protein 3

External Ids for BLCAP Gene

Summaries for BLCAP Gene

Entrez Gene Summary for BLCAP Gene

  • This gene encodes a tumor suppressor protein that reduces cell growth by stimulating apoptosis. The first intron of this gene contains the neuronatin gene, which is imprinted and only expressed from the paternal allele. This gene is imprinted in brain where it is differentially expressed from different promoters. Transcription from the upstream promoter occurs preferentially on the maternal allele, and transcripts are preferentially expressed from the downstream promoter on the paternal allele. Alternative promoters and alternative splicing result in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2009]

GeneCards Summary for BLCAP Gene

BLCAP (Bladder Cancer Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BLCAP Gene

  • May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Wiki entry for BLCAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLCAP Gene

Genomics for BLCAP Gene

Genomic Location for BLCAP Gene

37,492,472 bp from pter
37,527,931 bp from pter
35,460 bases
Minus strand

Genomic View for BLCAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BLCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLCAP Gene

Regulatory Elements for BLCAP Gene

Proteins for BLCAP Gene

  • Protein details for BLCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bladder cancer-associated protein
    Protein Accession:
    Secondary Accessions:
    • A2A2K7
    • O60629
    • Q9D3B5

    Protein attributes for BLCAP Gene

    87 amino acids
    Molecular mass:
    9876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BLCAP Gene

Proteomics data for BLCAP Gene at MOPED

Post-translational modifications for BLCAP Gene

No Post-translational modifications

No data available for DME Specific Peptides for BLCAP Gene

Domains for BLCAP Gene

Protein Domains for BLCAP Gene



  • Belongs to the BLCAP family.:
    • P62952
genes like me logo Genes that share domains with BLCAP: view

No data available for Gene Families for BLCAP Gene

Function for BLCAP Gene

Molecular function for BLCAP Gene

UniProtKB/Swiss-Prot Function: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Ontology (GO) - Molecular Function for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with BLCAP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BLCAP Gene

Localization for BLCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLCAP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BLCAP Gene COMPARTMENTS Subcellular localization image for BLCAP gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BLCAP: view

Pathways for BLCAP Gene

SuperPathways for BLCAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0030262 apoptotic nuclear changes IDA 17031575
genes like me logo Genes that share ontologies with BLCAP: view

No data available for Pathways by source for BLCAP Gene

Transcripts for BLCAP Gene

Unigene Clusters for BLCAP Gene

Bladder cancer associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BLCAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP3: - - - - -
SP4: - - -
SP5: - -

Relevant External Links for BLCAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BLCAP Gene

mRNA expression in normal human tissues for BLCAP Gene

mRNA differential expression in normal tissues according to GTEx for BLCAP Gene

This gene is overexpressed in Muscle - Skeletal (5.3).

SOURCE GeneReport for Unigene cluster for BLCAP Gene Hs.472651

mRNA Expression by UniProt/SwissProt for BLCAP Gene

Tissue specificity: Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.
genes like me logo Genes that share expressions with BLCAP: view

Orthologs for BLCAP Gene

This gene was present in the common ancestor of animals.

Orthologs for BLCAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BLCAP 36
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia BLCAP 36
  • 97.7 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia BLCAP 36
  • 96.55 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Blcap 36
  • 95.02 (n)
  • 100 (a)
Blcap 16
Blcap 37
  • 100 (a)
(Monodelphis domestica)
Mammalia BLCAP 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Blcap 36
  • 93.49 (n)
  • 100 (a)
(Gallus gallus)
Aves BLCAP 36
  • 86.59 (n)
  • 94.25 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia BLCAP 37
  • 94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12525 36
tropical clawed frog
(Silurana tropicalis)
Amphibia blcap 36
  • 78.16 (n)
  • 91.95 (a)
Str.634 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5031 36
(Danio rerio)
Actinopterygii blcap 36
  • 84.29 (n)
  • 94.25 (a)
blcap 37
  • 94 (a)
fruit fly
(Drosophila melanogaster)
Insecta bc10 37
  • 61 (a)
(Caenorhabditis elegans)
Secernentea Y73E7A.6 37
  • 40 (a)
Species with no ortholog for BLCAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BLCAP Gene

Gene Tree for BLCAP (if available)
Gene Tree for BLCAP (if available)

Paralogs for BLCAP Gene

No data available for Paralogs for BLCAP Gene

Variants for BLCAP Gene

Sequence variations from dbSNP and Humsavar for BLCAP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1043373 -- 37,517,456(-) GTTGC(A/C)CAGCT utr-variant-3-prime
rs1802289 -- 37,517,746(-) TGTAC(A/G)TTATG utr-variant-3-prime
rs1802291 -- 37,518,049(-) TGTGT(A/G)TTTCG utr-variant-3-prime
rs3752311 -- 37,517,594(+) GGCAA(C/G)AGAGA utr-variant-3-prime
rs3795147 -- 37,518,344(+) TGCTG(A/C)ACAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BLCAP Gene

Variant ID Type Subtype PubMed ID
nsv833968 CNV Gain 17160897

Relevant External Links for BLCAP Gene

HapMap Linkage Disequilibrium report

Disorders for BLCAP Gene

(1) University of Copenhagen DISEASES for BLCAP Gene

(2) Novoseek inferred disease relationships for BLCAP Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 57.8 3
tumors 11.2 5
genes like me logo Genes that share disorders with BLCAP: view

No data available for UniProtKB/Swiss-Prot for BLCAP Gene

Publications for BLCAP Gene

  1. Human BLCAP transcript: new editing events in normal and cancerous tissues. (PMID: 19908260) Galeano F. … Gallo A. (Int. J. Cancer 2010) 3 4 23
  2. Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure. (PMID: 10197429) Gromova I. … Celis J.E. (Electrophoresis 1999) 2 3 4
  3. Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma. (PMID: 16675915) Zuo Z. … Wu X. (Tumor Biol. 2006) 3 4 23
  4. Transcript- and tissue-specific imprinting of a tumour suppressor gene. (PMID: 18836209) Schulz R. … Oakey R.J. (Hum. Mol. Genet. 2009) 3 23
  5. Bladder cancer-associated protein, a potential prognostic biomarker in human bladder cancer. (PMID: 19783793) Moreira J.M. … Gromova I. (Mol. Cell Proteomics 2010) 3 23

Products for BLCAP Gene

Sources for BLCAP Gene

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