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Aliases for BLCAP Gene

Aliases for BLCAP Gene

  • Bladder Cancer Associated Protein 2 3 5
  • BC10 3 4
  • Bladder Cancer Related Protein (10kD) 3
  • Bladder Cancer 10 KDa Protein 4

External Ids for BLCAP Gene

Previous GeneCards Identifiers for BLCAP Gene

  • GC20M035874
  • GC20M036784
  • GC20M036831
  • GC20M035579
  • GC20M036130
  • GC20M032881

Summaries for BLCAP Gene

Entrez Gene Summary for BLCAP Gene

  • This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]

GeneCards Summary for BLCAP Gene

BLCAP (Bladder Cancer Associated Protein) is a Protein Coding gene. Diseases associated with BLCAP include Bladder Cancer, Somatic and Renal Cell Carcinoma.

UniProtKB/Swiss-Prot for BLCAP Gene

  • May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Wiki entry for BLCAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLCAP Gene

Genomics for BLCAP Gene

Regulatory Elements for BLCAP Gene

Enhancers for BLCAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BLCAP on UCSC Golden Path with GeneCards custom track

Promoters for BLCAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BLCAP on UCSC Golden Path with GeneCards custom track

Genomic Location for BLCAP Gene

37,492,472 bp from pter
37,527,931 bp from pter
35,460 bases
Minus strand

Genomic View for BLCAP Gene

Genes around BLCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLCAP Gene

Proteins for BLCAP Gene

  • Protein details for BLCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bladder cancer-associated protein
    Protein Accession:
    Secondary Accessions:
    • A2A2K7
    • O60629
    • Q9D3B5

    Protein attributes for BLCAP Gene

    87 amino acids
    Molecular mass:
    9876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BLCAP Gene

Proteomics data for BLCAP Gene at MOPED

Post-translational modifications for BLCAP Gene

No Post-translational modifications

Antibody Products

  • Abcam antibodies for BLCAP

No data available for DME Specific Peptides for BLCAP Gene

Domains & Families for BLCAP Gene

Protein Domains for BLCAP Gene


Suggested Antigen Peptide Sequences for BLCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BLCAP family.
  • Belongs to the BLCAP family.
genes like me logo Genes that share domains with BLCAP: view

No data available for Gene Families for BLCAP Gene

Function for BLCAP Gene

Molecular function for BLCAP Gene

UniProtKB/Swiss-Prot Function:
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Phenotypes for BLCAP Gene

genes like me logo Genes that share phenotypes with BLCAP: view

Animal Model Products

miRNA for BLCAP Gene

miRTarBase miRNAs that target BLCAP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BLCAP Gene

Localization for BLCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLCAP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BLCAP Gene COMPARTMENTS Subcellular localization image for BLCAP gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for BLCAP Gene

Pathways & Interactions for BLCAP Gene

SuperPathways for BLCAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BLCAP Gene


No data available for Pathways by source and SIGNOR curated interactions for BLCAP Gene

Drugs & Compounds for BLCAP Gene

No Compound Related Data Available

Transcripts for BLCAP Gene

Unigene Clusters for BLCAP Gene

Bladder cancer associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BLCAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP3: - - - - -
SP4: - - -
SP5: - -

Relevant External Links for BLCAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BLCAP Gene

mRNA expression in normal human tissues for BLCAP Gene

mRNA differential expression in normal tissues according to GTEx for BLCAP Gene

This gene is overexpressed in Muscle - Skeletal (x5.3).

SOURCE GeneReport for Unigene cluster for BLCAP Gene Hs.472651

mRNA Expression by UniProt/SwissProt for BLCAP Gene

Tissue specificity: Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.
genes like me logo Genes that share expression patterns with BLCAP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BLCAP Gene

Orthologs for BLCAP Gene

This gene was present in the common ancestor of animals.

Orthologs for BLCAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BLCAP 35
  • 97.7 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia BLCAP 35
  • 96.55 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Blcap 35
  • 95.02 (n)
  • 100 (a)
Blcap 16
Blcap 36
  • 100 (a)
(Pan troglodytes)
Mammalia BLCAP 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Blcap 35
  • 93.49 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia BLCAP 36
  • 94 (a)
(Gallus gallus)
Aves BLCAP 35
  • 86.59 (n)
  • 94.25 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia BLCAP 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia blcap 35
  • 78.16 (n)
  • 91.95 (a)
Str.634 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12525 35
(Danio rerio)
Actinopterygii blcap 35
  • 84.29 (n)
  • 94.25 (a)
blcap 36
  • 94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5031 35
fruit fly
(Drosophila melanogaster)
Insecta bc10 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea Y73E7A.6 36
  • 40 (a)
Species with no ortholog for BLCAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BLCAP Gene

Gene Tree for BLCAP (if available)
Gene Tree for BLCAP (if available)

Paralogs for BLCAP Gene

No data available for Paralogs for BLCAP Gene

Variants for BLCAP Gene

Sequence variations from dbSNP and Humsavar for BLCAP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_068908 -
VAR_068909 -
VAR_068910 -
rs4809687 -- 37,526,295(+) ACCCC(C/G/T)CCTCA intron-variant, upstream-variant-2KB
rs6019102 -- 37,524,942(+) TAACA(C/T)GCTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BLCAP Gene

Variant ID Type Subtype PubMed ID
nsv833968 CNV Gain 17160897

Variation tolerance for BLCAP Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BLCAP Gene

Disorders for BLCAP Gene

MalaCards: The human disease database

(2) MalaCards diseases for BLCAP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder cancer, somatic
  • bladder carcinoma
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BLCAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for BLCAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BLCAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BLCAP Gene

Publications for BLCAP Gene

  1. Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure. (PMID: 10197429) Gromova I. … Celis J.E. (Electrophoresis 1999) 2 3 4 67
  2. BLCAP arrests G1/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells. (PMID: 26986503) Zhao M. … Wu X. (Oncol. Rep. 2016) 2 3
  3. Bladder cancer-associated protein, a potential prognostic biomarker in human bladder cancer. (PMID: 19783793) Moreira J.M. … Gromova I. (Mol. Cell Proteomics 2010) 3 23
  4. Human BLCAP transcript: new editing events in normal and cancerous tissues. (PMID: 19908260) Galeano F. … Gallo A. (Int. J. Cancer 2010) 3 23
  5. Transcript- and tissue-specific imprinting of a tumour suppressor gene. (PMID: 18836209) Schulz R. … Oakey R.J. (Hum. Mol. Genet. 2009) 3 23

Products for BLCAP Gene

Sources for BLCAP Gene