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Aliases for BLACE Gene

Subcategory (RNA class) for BLACE Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for BLACE Gene

  • B-Cell Acute Lymphoblastic Leukemia Expressed 2 3 5

External Ids for BLACE Gene

Previous GeneCards Identifiers for BLACE Gene

  • GC00U901009
  • GC07U901528
  • GC07M154842
  • GC07M155149

Summaries for BLACE Gene

GeneCards Summary for BLACE Gene

BLACE (B-Cell Acute Lymphoblastic Leukemia Expressed) is an RNA Gene, and is affiliated with the ncRNA class.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLACE Gene

Genomics for BLACE Gene

Regulatory Elements for BLACE Gene

Enhancers for BLACE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G155344 1.6 FANTOM5 Ensembl ENCODE 12.4 +23.0 22950 1.5 HDGF SIN3A ZNF2 GLIS2 CBX5 ZNF143 KLF13 ZNF263 REST ZNF592 INSIG1 BLACE LOC105375591 GC07P155346 LOC105375592
GH07G155471 1.4 VISTA ENCODE 10 -104.3 -104300 1.8 HDGF ZSCAN4 GLI4 GLIS2 EGR1 KDM4B EGR2 SMARCA5 SP1 ZSCAN16 ENSG00000227365 CNPY1 BLACE EN2
GH07G155740 1.4 Ensembl ENCODE dbSUPER 9.7 -373.9 -373927 3.2 HDAC1 ATF1 RB1 ZSCAN4 ZNF2 RAD21 ZNF335 GLIS2 ZNF207 RELB PAXIP1-AS2 ENSG00000273183 PAXIP1-AS1 ENSG00000236544 EN2 BLACE RBM33 PIR49030 LOC100506302
GH07G155412 1.1 ENCODE 10.8 -44.9 -44907 0.2 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ENSG00000218672 ENSG00000236544 EN2 BLACE ENSG00000227365 LOC105375594 ENSG00000260426
GH07G155276 1.1 dbSUPER 10.2 +90.0 89992 2.3 CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PAXIP1-AS2 ENSG00000273183 PAXIP1-AS1 BLACE LOC105375589 INSIG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BLACE on UCSC Golden Path with GeneCards custom track

Genomic Location for BLACE Gene

Chromosome:
7
Start:
155,356,985 bp from pter
End:
155,367,934 bp from pter
Size:
10,950 bases
Orientation:
Minus strand

Genomic View for BLACE Gene

Genes around BLACE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLACE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLACE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLACE Gene

Proteins for BLACE Gene

  • Protein details for BLACE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D250-BLACE_HUMAN
    Recommended name:
    B-cell acute lymphoblastic leukemia-expressed protein
    Protein Accession:
    A4D250

    Protein attributes for BLACE Gene

    Size:
    179 amino acids
    Molecular mass:
    19503 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AY166699; Type=Frameshift; Positions=111; Evidence={ECO:0000305};

neXtProt entry for BLACE Gene

Post-translational modifications for BLACE Gene

No Post-translational modifications

Other Protein References for BLACE Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for BLACE Gene

Domains & Families for BLACE Gene

Protein Domains for BLACE Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BLACE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLACE: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BLACE Gene

Function for BLACE Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BLACE Gene

Localization for BLACE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLACE gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BLACE Gene

Pathways & Interactions for BLACE Gene

SuperPathways for BLACE Gene

No Data Available

Interacting Proteins for BLACE Gene

Gene Ontology (GO) - Biological Process for BLACE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BLACE Gene

Drugs & Compounds for BLACE Gene

No Compound Related Data Available

Transcripts for BLACE Gene

mRNA/cDNA for BLACE Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BLACE Gene

No ASD Table

Relevant External Links for BLACE Gene

GeneLoc Exon Structure for
BLACE
ECgene alternative splicing isoforms for
BLACE

Expression for BLACE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLACE Gene

mRNA differential expression in normal tissues according to GTEx for BLACE Gene

This gene is overexpressed in Testis (x20.4), Whole Blood (x11.3), Fallopian Tube (x10.7), and Brain - Cerebellum (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of BLACE Gene:

BLACE

SOURCE GeneReport for Unigene cluster for BLACE Gene:

Hs.521326
genes like me logo Genes that share expression patterns with BLACE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLACE Gene

Orthologs for BLACE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BLACE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLACE 35
  • 98 (a)
OneToOne
Species where no ortholog for BLACE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BLACE Gene

ENSEMBL:
Gene Tree for BLACE (if available)
TreeFam:
Gene Tree for BLACE (if available)

Paralogs for BLACE Gene

No data available for Paralogs for BLACE Gene

Variants for BLACE Gene

Sequence variations from dbSNP and Humsavar for BLACE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000166031 -- 155,369,244(+) GTGGC(C/T)CTGAA intron-variant, upstream-variant-2KB
rs1000344043 -- 155,361,481(+) TGCTC(A/G)TGGAC intron-variant
rs1000619496 -- 155,366,463(+) TGAAA(A/G)GTCTC intron-variant
rs1000623028 -- 155,368,905(+) TAGGA(C/T)TTGAT intron-variant, upstream-variant-2KB
rs1000796622 -- 155,357,341(+) AGTTA(A/T)CGCTG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for BLACE Gene

Variant ID Type Subtype PubMed ID
nsv472044 CNV novel sequence insertion 20440878
nsv473675 CNV novel sequence insertion 20440878
nsv473947 CNV novel sequence insertion 20440878
nsv478993 CNV novel sequence insertion 20440878
nsv479205 CNV novel sequence insertion 20440878
nsv479558 CNV novel sequence insertion 20440878
nsv479653 CNV novel sequence insertion 20440878
nsv824408 CNV gain 20364138

Variation tolerance for BLACE Gene

Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BLACE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLACE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLACE Gene

Disorders for BLACE Gene

Relevant External Links for BLACE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BLACE

No disorders were found for BLACE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BLACE Gene

Publications for BLACE Gene

  1. A gene expressed exclusively in acute B lymphoblastic leukemias. (PMID: 14667812) Vialle-Castellano A. … van Baren N. (Genomics 2004) 2 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for BLACE Gene

Sources for BLACE Gene

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