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Aliases for BLACE Gene

Subcategory (RNA class) for BLACE Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for BLACE Gene

  • B-Cell Acute Lymphoblastic Leukemia Expressed 2 3 5

External Ids for BLACE Gene

Previous GeneCards Identifiers for BLACE Gene

  • GC00U901009
  • GC07U901528
  • GC07M154842
  • GC07M155149

Summaries for BLACE Gene

GeneCards Summary for BLACE Gene

BLACE (B-Cell Acute Lymphoblastic Leukemia Expressed) is an RNA Gene, and is affiliated with the ncRNA class.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLACE Gene

Genomics for BLACE Gene

Regulatory Elements for BLACE Gene

Enhancers for BLACE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F155203 0.8 ENCODE 16.2 +161.1 161077 5.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 YBX1 ZNF2 YY1 LOC105375589 BLACE ENSG00000227365 PAXIP1-AS2 LOC105375580 PAXIP1-AS1 LOC105375586 INSIG1 SHH ENSG00000278998
GH07F155344 1.5 FANTOM5 Ensembl ENCODE 12.4 +23.0 22950 1.5 HDGF CBX3 TBL1XR1 SIN3A NFXL1 ZNF2 RAD21 GLIS2 EGR1 CBX5 INSIG1 BLACE LOC105375591 GC07P155346 LOC105375592
GH07F155189 1 ENCODE 11.1 +178.4 178370 0.5 ZNF664 ATF3 HMBOX1 CEBPB TRIM24 CEBPG RAD21 BLACE ENSG00000217825 RN7SKP280
GH07F155338 0.8 Ensembl ENCODE 10.9 +29.0 29004 0.9 RING1 BHLHE40 EBF1 MNT PAXIP1-AS2 ENSG00000273183 INSIG1 BLACE PAXIP1-AS1 EN2 ENSG00000236544 LOC105375592 GC07P155346
GH07F155408 0.4 ENCODE 10.9 -41.0 -40975 0.5 MAZ TEAD1 TEAD4 ZNF76 ZIC2 TEAD3 ZFHX2 GLIS2 ZNF610 GLIS1 EN2 ENSG00000236544 BLACE ENSG00000260426 LOC105375594
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BLACE on UCSC Golden Path with GeneCards custom track

Genomic Location for BLACE Gene

Chromosome:
7
Start:
155,356,985 bp from pter
End:
155,367,934 bp from pter
Size:
10,950 bases
Orientation:
Minus strand

Genomic View for BLACE Gene

Genes around BLACE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLACE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLACE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLACE Gene

Proteins for BLACE Gene

  • Protein details for BLACE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D250-BLACE_HUMAN
    Recommended name:
    B-cell acute lymphoblastic leukemia-expressed protein
    Protein Accession:
    A4D250

    Protein attributes for BLACE Gene

    Size:
    179 amino acids
    Molecular mass:
    19503 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AY166699; Type=Frameshift; Positions=111; Evidence={ECO:0000305};

neXtProt entry for BLACE Gene

Post-translational modifications for BLACE Gene

No Post-translational modifications

Other Protein References for BLACE Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for BLACE Gene

Domains & Families for BLACE Gene

Protein Domains for BLACE Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BLACE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLACE: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BLACE Gene

Function for BLACE Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BLACE Gene

Localization for BLACE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BLACE Gene COMPARTMENTS Subcellular localization image for BLACE gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BLACE Gene

Pathways & Interactions for BLACE Gene

SuperPathways for BLACE Gene

No Data Available

Interacting Proteins for BLACE Gene

Gene Ontology (GO) - Biological Process for BLACE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BLACE Gene

Transcripts for BLACE Gene

mRNA/cDNA for BLACE Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BLACE Gene

No ASD Table

Relevant External Links for BLACE Gene

GeneLoc Exon Structure for
BLACE
ECgene alternative splicing isoforms for
BLACE

Expression for BLACE Gene

mRNA expression in normal human tissues for BLACE Gene

mRNA differential expression in normal tissues according to GTEx for BLACE Gene

This gene is overexpressed in Testis (x20.4), Whole Blood (x11.3), Fallopian Tube (x10.7), and Brain - Cerebellum (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of BLACE Gene:

BLACE

SOURCE GeneReport for Unigene cluster for BLACE Gene:

Hs.521326
genes like me logo Genes that share expression patterns with BLACE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BLACE Gene

Orthologs for BLACE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BLACE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLACE 35
  • 98 (a)
OneToOne
Species where no ortholog for BLACE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BLACE Gene

ENSEMBL:
Gene Tree for BLACE (if available)
TreeFam:
Gene Tree for BLACE (if available)

Paralogs for BLACE Gene

No data available for Paralogs for BLACE Gene

Variants for BLACE Gene

Sequence variations from dbSNP and Humsavar for BLACE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10227751 -- 155,368,678(-) ttgcc(C/T)tggtt intron-variant, upstream-variant-2KB
rs10230779 -- 155,365,966(-) aaaaG(C/G)ATTAA intron-variant
rs10233008 -- 155,359,328(-) GTATG(A/C)TTTAG intron-variant
rs10233153 -- 155,359,174(-) GTTTG(C/T)GTATG intron-variant
rs10233517 -- 155,358,889(-) CTCTC(C/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BLACE Gene

Variant ID Type Subtype PubMed ID
nsv472044 CNV novel sequence insertion 20440878
nsv473675 CNV novel sequence insertion 20440878
nsv473947 CNV novel sequence insertion 20440878
nsv478993 CNV novel sequence insertion 20440878
nsv479205 CNV novel sequence insertion 20440878
nsv479558 CNV novel sequence insertion 20440878
nsv479653 CNV novel sequence insertion 20440878
nsv824408 CNV gain 20364138

Variation tolerance for BLACE Gene

Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BLACE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLACE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLACE Gene

Disorders for BLACE Gene

Relevant External Links for BLACE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BLACE

No disorders were found for BLACE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BLACE Gene

Publications for BLACE Gene

  1. A gene expressed exclusively in acute B lymphoblastic leukemias. (PMID: 14667812) Vialle-Castellano A. … van Baren N. (Genomics 2004) 2 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for BLACE Gene

Sources for BLACE Gene

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