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Aliases for BIVM-ERCC5 Gene

Aliases for BIVM-ERCC5 Gene

  • BIVM-ERCC5 Readthrough 2 3 5
  • BIVM-ERCC5 Protein 3
  • ERCC5-202 3

External Ids for BIVM-ERCC5 Gene

Previous GeneCards Identifiers for BIVM-ERCC5 Gene

  • GC13U900839
  • GC13P103460
  • GC13P103461

Summaries for BIVM-ERCC5 Gene

Entrez Gene Summary for BIVM-ERCC5 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring BIVM (basic, immunoglobulin-like variable motif containing) and ERCC5 (excision repair cross-complementing rodent repair deficiency, complementation group 5) genes on chromosome 13. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for BIVM-ERCC5 Gene

BIVM-ERCC5 (BIVM-ERCC5 Readthrough) is a Protein Coding gene. Among its related pathways are Nucleotide excision repair. GO annotations related to this gene include single-stranded DNA binding and nuclease activity. An important paralog of this gene is ERCC5.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIVM-ERCC5 Gene

Genomics for BIVM-ERCC5 Gene

Regulatory Elements for BIVM-ERCC5 Gene

Enhancers for BIVM-ERCC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G102798 1.1 ENCODE 0.7 +0.9 906 3.3 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 BIVM METTL21EP BIVM-ERCC5 GC13M102806
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BIVM-ERCC5 on UCSC Golden Path with GeneCards custom track

Promoters for BIVM-ERCC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000065344 490 3201 PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for BIVM-ERCC5 Gene

Chromosome:
13
Start:
102,799,110 bp from pter
End:
102,876,001 bp from pter
Size:
76,892 bases
Orientation:
Plus strand

Genomic View for BIVM-ERCC5 Gene

Genes around BIVM-ERCC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIVM-ERCC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIVM-ERCC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIVM-ERCC5 Gene

Proteins for BIVM-ERCC5 Gene

  • Protein details for BIVM-ERCC5 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMW8
    Recommended name:
    BIVM-ERCC5 readthrough
    Protein Accession:
    R4GMW8

    Protein attributes for BIVM-ERCC5 Gene

    Size:
    1385 amino acids
    Molecular mass:
    156070 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BIVM-ERCC5 Gene

Post-translational modifications for BIVM-ERCC5 Gene

No Post-translational modifications

Other Protein References for BIVM-ERCC5 Gene

No data available for DME Specific Peptides for BIVM-ERCC5 Gene

Domains & Families for BIVM-ERCC5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BIVM-ERCC5: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BIVM-ERCC5 Gene

Function for BIVM-ERCC5 Gene

Gene Ontology (GO) - Molecular Function for BIVM-ERCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
GO:0003824 catalytic activity IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004520 endodeoxyribonuclease activity IBA --
genes like me logo Genes that share ontologies with BIVM-ERCC5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BIVM-ERCC5 Gene

Localization for BIVM-ERCC5 Gene

Gene Ontology (GO) - Cellular Components for BIVM-ERCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with BIVM-ERCC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for BIVM-ERCC5 Gene

Pathways & Interactions for BIVM-ERCC5 Gene

SuperPathways for BIVM-ERCC5 Gene

SuperPathway Contained pathways
1 Nucleotide excision repair
genes like me logo Genes that share pathways with BIVM-ERCC5: view

Pathways by source for BIVM-ERCC5 Gene

1 KEGG pathway for BIVM-ERCC5 Gene

Interacting Proteins for BIVM-ERCC5 Gene

Gene Ontology (GO) - Biological Process for BIVM-ERCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006289 nucleotide-excision repair IEA --
GO:0006295 nucleotide-excision repair, DNA incision, 3-to lesion IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with BIVM-ERCC5: view

No data available for SIGNOR curated interactions for BIVM-ERCC5 Gene

Drugs & Compounds for BIVM-ERCC5 Gene

No Compound Related Data Available

Transcripts for BIVM-ERCC5 Gene

mRNA/cDNA for BIVM-ERCC5 Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BIVM-ERCC5 Gene

No ASD Table

Relevant External Links for BIVM-ERCC5 Gene

GeneLoc Exon Structure for
BIVM-ERCC5
ECgene alternative splicing isoforms for
BIVM-ERCC5

Expression for BIVM-ERCC5 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIVM-ERCC5 Gene

Orthologs for BIVM-ERCC5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BIVM-ERCC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIVM-ERCC5 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIVM 35
  • 71 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ERCC5 35
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ercc5 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves ERCC5 35
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ercc5 35
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mus201 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gen-1 35
  • 21 (a)
ManyToMany
xpg-1 35
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD2 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for BIVM-ERCC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BIVM-ERCC5 Gene

ENSEMBL:
Gene Tree for BIVM-ERCC5 (if available)
TreeFam:
Gene Tree for BIVM-ERCC5 (if available)

Paralogs for BIVM-ERCC5 Gene

Paralogs for BIVM-ERCC5 Gene

(3) SIMAP similar genes for BIVM-ERCC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BIVM-ERCC5: view

Variants for BIVM-ERCC5 Gene

Sequence variations from dbSNP and Humsavar for BIVM-ERCC5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs121434570 Pathogenic 102,872,397(+) TTAGA(A/G/T)AATAT reference, missense, stop-gained
rs121434571 Pathogenic 102,866,687(+) AGAGG(C/T)GCAGT reference, missense
rs121434572 Pathogenic 102,861,621(+) ACATC(C/T)GAAGG reference, stop-gained
rs121434573 Pathogenic 102,856,110(+) CATTA(C/T)AGGTA reference, stop-gained
rs121434574 Pathogenic 102,852,244(+) TCGTC(A/C/T)TATTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BIVM-ERCC5 Gene

Variant ID Type Subtype PubMed ID
esv2661939 CNV deletion 23128226
esv3633382 CNV loss 21293372
nsv1048497 CNV gain 25217958
nsv562981 CNV gain 21841781

Relevant External Links for BIVM-ERCC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIVM-ERCC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BIVM-ERCC5 Gene

Disorders for BIVM-ERCC5 Gene

Relevant External Links for BIVM-ERCC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIVM-ERCC5

No disorders were found for BIVM-ERCC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIVM-ERCC5 Gene

Publications for BIVM-ERCC5 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for BIVM-ERCC5 Gene

Sources for BIVM-ERCC5 Gene

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