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Aliases for BIRC8 Gene

Aliases for BIRC8 Gene

  • Baculoviral IAP Repeat Containing 8 2 3
  • Inhibitor Of Apoptosis-Like Protein 2 2 3 4
  • IAP-Like Protein 2 2 3 4
  • Testis-Specific Inhibitor Of Apoptosis 3 4
  • Baculoviral IAP Repeat-Containing 8 2 3
  • ILP-2 3 4
  • ILP2 3 4
  • Baculoviral IAP Repeat-Containing Protein 8 3
  • HILP2 3

External Ids for BIRC8 Gene

Summaries for BIRC8 Gene

GeneCards Summary for BIRC8 Gene

BIRC8 (Baculoviral IAP Repeat Containing 8) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protease binding and scaffold protein binding. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC8 Gene

  • Protects against apoptosis mediated by BAX

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC8 Gene

Genomics for BIRC8 Gene

Genomic Location for BIRC8 Gene

Start:
53,289,601 bp from pter
End:
53,291,626 bp from pter
Size:
2,026 bases
Orientation:
Minus strand

Genomic View for BIRC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIRC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC8 Gene

Regulatory Elements for BIRC8 Gene

Proteins for BIRC8 Gene

  • Protein details for BIRC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P09-BIRC8_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 8
    Protein Accession:
    Q96P09
    Secondary Accessions:
    • Q6IPY1
    • Q96RW5

    Protein attributes for BIRC8 Gene

    Size:
    236 amino acids
    Molecular mass:
    27089 Da
    Quaternary structure:
    • Binds to caspase-9

    Three dimensional structures from OCA and Proteopedia for BIRC8 Gene

neXtProt entry for BIRC8 Gene

Proteomics data for BIRC8 Gene at MOPED

Post-translational modifications for BIRC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIRC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BIRC8 Gene

Domains for BIRC8 Gene

Gene Families for BIRC8 Gene

HGNC:
  • BIRC :Baculoviral IAP repeat containing

Protein Domains for BIRC8 Gene

UniProtKB/Swiss-Prot:

BIRC8_HUMAN
Family:
  • Belongs to the IAP family.:
    • Q96P09
Similarity:
  • Contains 1 BIR repeat.:
    • Q96P09
  • Contains 1 RING-type zinc finger.:
    • Q96P09
genes like me logo Genes that share domains with BIRC8: view

Function for BIRC8 Gene

Molecular function for BIRC8 Gene

UniProtKB/Swiss-Prot Function: Protects against apoptosis mediated by BAX

Gene Ontology (GO) - Molecular Function for BIRC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA --
genes like me logo Genes that share ontologies with BIRC8: view

Phenotypes for BIRC8 Gene

GenomeRNAi human phenotypes for BIRC8:
genes like me logo Genes that share phenotypes with BIRC8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BIRC8 Gene

Localization for BIRC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC8 Gene COMPARTMENTS Subcellular localization image for BIRC8 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BIRC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005876 NOT spindle microtubule IBA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with BIRC8: view

Pathways for BIRC8 Gene

genes like me logo Genes that share pathways with BIRC8: view

Pathways by source for BIRC8 Gene

Gene Ontology (GO) - Biological Process for BIRC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0016567 protein ubiquitination IBA --
GO:0043066 negative regulation of apoptotic process IBA --
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process --
GO:0043524 negative regulation of neuron apoptotic process IEA --
genes like me logo Genes that share ontologies with BIRC8: view

Transcripts for BIRC8 Gene

mRNA/cDNA for BIRC8 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BIRC8 Gene

Baculoviral IAP repeat containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC8 Gene

No ASD Table

Relevant External Links for BIRC8 Gene

GeneLoc Exon Structure for
BIRC8
ECgene alternative splicing isoforms for
BIRC8

Expression for BIRC8 Gene

mRNA expression in normal human tissues for BIRC8 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC8 Gene

This gene is overexpressed in Testis (52.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BIRC8 Gene

SOURCE GeneReport for Unigene cluster for BIRC8 Gene Hs.348263

mRNA Expression by UniProt/SwissProt for BIRC8 Gene

Q96P09-BIRC8_HUMAN
Tissue specificity: Testis specific in normal tissues
genes like me logo Genes that share expressions with BIRC8: view

Orthologs for BIRC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC8 36
  • 98.59 (n)
  • 98.31 (a)
cow
(Bos Taurus)
Mammalia XIAP 37
  • 36 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BIRC4 37
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Xiap 37
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 32 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 24 (a)
OneToMany
chicken
(Gallus gallus)
Aves IAP3 37
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii birc4 36
xiap 37
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Iap2 37
  • 16 (a)
ManyToMany
th 37
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 4 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 18 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 11 (a)
ManyToMany
Species with no ortholog for BIRC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC8 Gene

ENSEMBL:
Gene Tree for BIRC8 (if available)
TreeFam:
Gene Tree for BIRC8 (if available)

Paralogs for BIRC8 Gene

Paralogs for BIRC8 Gene

Selected SIMAP similar genes for BIRC8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BIRC8: view

Variants for BIRC8 Gene

Sequence variations from dbSNP and Humsavar for BIRC8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2865248 -- 53,290,321(+) TTGTT(A/G)ACGGA synonymous-codon, reference
rs3038902 -- 53,293,262(+) atata(-/TA)gacaa upstream-variant-2KB
rs4801973 -- 53,292,676(+) ATAGA(C/T)AGATA upstream-variant-2KB
rs7260390 -- 53,290,658(+) ACTGT(A/T)ATCTA utr-variant-5-prime
rs8106055 -- 53,289,541(+) GGCTT(C/G)CATTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BIRC8 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
nsv912342 CNV Gain 21882294
esv2718812 CNV Deletion 23290073
esv6489 OTHER Inversion 19470904
esv5629 OTHER Inversion 19470904
nsv817865 CNV Gain 17921354

Relevant External Links for BIRC8 Gene

HapMap Linkage Disequilibrium report
BIRC8

Disorders for BIRC8 Gene

Relevant External Links for BIRC8

Genetic Association Database (GAD)
BIRC8
Human Genome Epidemiology (HuGE) Navigator
BIRC8
genes like me logo Genes that share disorders with BIRC8: view

No data available for UniProtKB/Swiss-Prot for BIRC8 Gene

Publications for BIRC8 Gene

  1. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. (PMID: 11390657) Richter B.W.M. … Duckett C.S. (Mol. Cell. Biol. 2001) 2 3 4
  2. Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript. (PMID: 11597143) Lagace M. … Korneluk R.G. (Genomics 2001) 3 4
  3. The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. (PMID: 15485395) Shin H. … Salvesen G.S. (Biochem. J. 2005) 3 4
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  5. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PMID: 21110914) Grant M.M. (BMB Rep 2010) 3

Products for BIRC8 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate BIRC8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for BIRC8
    • Block miRNA regulation of BIRC8 using miScript Target Protectors

    Sources for BIRC8 Gene

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