BIRC8 Gene
protein-coding GIFtS: 50
GCID: GC19M053792
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|
baculoviral IAP repeat containing 8(Previous name: baculoviral IAP repeat-containing 8 )
| |
Aliases
for BIRC8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Baculoviral IAP Repeat Containing 81 2 | | Testis-Specific Inhibitor Of Apoptosis2 3 | | ILP-21 2 3 | | ILP22 3 | | Baculoviral IAP Repeat-Containing 81 2 | | IAP-Like Protein 22 3 | | HILP21 | | Baculoviral IAP Repeat-Containing Protein 82 | | Inhibitor Of Apoptosis-Like Protein 22 3 | | |
Export aliases for BIRC8 gene to outside databasesPrevious GC identifers: GC19M054438 GC19M054154 GC19M058468 GC19M058484 GC19M050113 |
Summaries
for BIRC8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BIRC8_HUMAN, Q96P09Function: Protects against apoptosis mediated by BAX
|
Genomic Views
for BIRC8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BIRC8 gene promoter:
HFH-3 Nkx3-1 Nkx3-1 v4 Spz1 FOXD1 Nkx3-1 v1 Evi-1 FOXI1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for BIRC8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.3-q13.4BIRC8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M053792: view genomic region
(about GC identifiers)
Start:
|
53,792,854 bp from pter |
End:
|
53,794,875 bp from pter |
Size:
|
2,022 bases |
Orientation:
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minus strand |
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Proteins
for BIRC8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIRC8_HUMAN, Q96P09 (See
protein sequence)Recommended Name: Baculoviral IAP repeat-containing protein 8 Size: 236 amino acids; 27089 Da
Subunit: Binds to caspase-9
Subcellular location: Cytoplasm (Probable)
2 PDB 3D structures from  and Proteopedia  for BIRC8:1XB0 (3D)
1XB1 (3D)
Secondary accessions: Q6IPY1 Q96RW5Explore the universe of human proteins at neXtProt for BIRC8: NX_Q96P09
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96P09
BIRC8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_203127.3
ENSEMBL proteins: ENSP00000412957
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
BIRC8 for ontologies About GeneDecksing
BIRC8 Antibody Products:
Assay Products for BIRC8: |
Protein
Domains /
Families
for BIRC8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BIRC8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96P09ProtoNet protein and cluster: Q96P09 2 Blocks protein families: IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR) IPB001841 Zn-finger
UniProtKB/Swiss-Prot: BIRC8_HUMAN, Q96P09Similarity: Belongs to the IAP familySimilarity: Contains 1 BIR repeatSimilarity: Contains 1 RING-type zinc finger |
Function
for BIRC8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIRC8_HUMAN, Q96P09Function: Protects against apoptosis mediated by BAX
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BIRC8 (NM_033341) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIRC8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC8 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
BIRC8 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for BIRC8:
|
Pathways & Interactions
for BIRC8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis and survival_Apoptotic TNF-family pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for BIRC8
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIRC8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/16 Interacting proteins for BIRC8 (Q96P093 ENSP000004129574) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
-- | -- | | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IEA | -- | | GO:0043524 | negative regulation of neuron apoptotic process |
IEA | -- |
BIRC8 for ontologies About GeneDecksing
|
Drugs & Compounds
for BIRC8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BIRC8
Search CenterWatch for drugs/clinical trials and news about BIRC8
|
Transcripts
for BIRC8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BIRC8 gene: NM_033341.4 Unigene Cluster for BIRC8: Baculoviral IAP repeat containing 8 Hs.348263 [show with all ESTs]Unigene Representative Sequence: AF4204401 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000426466(uc002qbk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BIRC8 (NM_033341) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIRC8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC8 |
Additional cDNA sequence: AF420440.1 BC039318.1 BC046168.1 BC056914.1 BC071665.1 1 DOTS entry: DT.95157906 19 AceView cDNA sequences: BM554544 BC056914 NM_033341 CD635059 CD360013 BC071665 BM553272 CD635055 BC046168 AF420440 BG773530 CD635061 BC039318 CD635057 CD635053 CD635051 BP369062 BI829221 BI463479
GeneLoc Exon Structure
|
Expression
for BIRC8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BIRC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGCGCGG
About this image
See BIRC8 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.348263
UniProtKB/Swiss-Prot: BIRC8_HUMAN, Q96P09Tissue specificity: Testis specific in normal tissues
SABiosciences Expression via Pathway-Focused PCR Array including BIRC8: | Apoptosis 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BIRC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC8 |
Orthologs
for BIRC8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BIRC8 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
Q8UVF8_CHICK6 |
baculoviral IAP repeat-containing 4 |
25(a) |
1 → many |
4(15779875-15797496) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
25(a) |
1 → many |
GL343409.1(47530-53370) |
zebrafish
(Danio rerio) |
Actinopterygii |
birc42 |
baculoviral IAP repeat-containing 4 |
75.91(n) |
|
373108 AF439767.1 |
ENSEMBL Gene Tree for BIRC8 (if available)
TreeFam Gene Tree for BIRC8 (if available) |
Paralogs
for BIRC8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BIRC8 gene
- BIRC32 BIRC72 XIAP2 BIRC22
3 SIMAP similar genes for BIRC8 using alignment to 2 protein entries: BIRC8_HUMAN (see all proteins):XIAP ILP3 BIRC3
BIRC8 for paralogs About GeneDecksing
|
Genomic Variants
for BIRC8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BIRC8 (53792854 - 53794875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BIRC8
1 CNV: 9811
1 Inversion: 59895 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC8 |
|
Disorders
/ Diseases
for BIRC8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 BIRC8 for disorders About MalaCards
BIRC8 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: BIRC8 (1 document)
Export disorders for BIRC8 gene to outside databases
|
Publications
for BIRC8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BIRC8 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with BIRC8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. (PubMed id 11390657)1, 2, 3 Richter B.W.M.... Duckett C.S. (2001)
- The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. (PubMed id 15485395)1, 2 Shin H....Salvesen G.S. (2005)
- Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript. (PubMed id 11597143)1, 2 Lagace M.... Korneluk R.G. (2001)
- Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
|
External Searches for BIRC8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BIRC8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BIRC8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BIRC8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BIRC8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BIRC8 gene:
Search GeneIP for patents involving BIRC8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BIRC8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BIRC8 | | OriGene shRNA RFP for BIRC8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIRC8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC8 | | | OriGene Protein Over-expression Lysate for BIRC8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BIRC8 | | OriGene 3'-UTR Clone for BIRC8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BIRC8 | | OriGene Custom Protein Services for BIRC8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BIRC8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC8 |
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| | | | Search Tocris compounds for BIRC8 |
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 | | | BIRC8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC8 |
|  |  |  | | | | ThermoFisher Antibodies for BIRC8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC8 |
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