BIRC7 Gene
protein-coding GIFtS: 60
GCID: GC20P061867
|
|
baculoviral IAP repeat containing 7(Previous name: baculoviral IAP repeat-containing 7 )
| |
Aliases
for BIRC7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Baculoviral IAP Repeat Containing 71 2 | | RING Finger Protein 502 3 | | KIAP1 2 3 5 | | Baculoviral IAP Repeat-Containing 71 | | ML-IAP1 2 3 | | Mliap1 | | RNF501 2 3 | | Baculoviral IAP Repeat-Containing Protein 72 | | LIVIN2 3 5 | | Livin Inhibitor Of Apoptosis2 | | MLIAP2 3 5 | | EC 6.3.2.-3 | | Kidney Inhibitor Of Apoptosis Protein2 3 | | Livin3 | | Melanoma Inhibitor Of Apoptosis Protein2 3 | | |
Export aliases for BIRC7 gene to outside databasesPrevious GC identifers: GC20P061744 GC20P062546 GC20P062593 GC20P061337 GC20P058592 |
Summaries
for BIRC7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BIRC7:
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains asingle copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essentialfor inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptoticactivity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found forthis gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells fromapoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5Function: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles inapoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibitionof CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor,its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it fordegradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability ofDIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemicalagents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation ofMAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocksetoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augmentskilling
Gene Wiki entry for BIRC7
|
Genomic Views
for BIRC7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011333.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BIRC7 gene promoter:
N-Myc HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BIRC7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.3BIRC7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P061867: view genomic region
(about GC identifiers)
Start:
|
61,867,235 bp from pter |
End:
|
61,871,859 bp from pter |
Size:
|
4,625 bases |
Orientation:
|
plus strand |
|
Proteins
for BIRC7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5 (See
protein sequence)Recommended Name: Baculoviral IAP repeat-containing protein 7 Size: 298 amino acids; 32798 Da
Subunit: Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptoticsuppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain
Subcellular location: Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout thecytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found inthe peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleusshows positive correlation with the increase in apoptosis
6/13 PDB 3D structures from  and Proteopedia  for BIRC7 (see all 13):1OXN (3D)
1OXQ (3D)
1OY7 (3D)
1TW6 (3D)
2I3H (3D)
2I3I (3D)
Secondary accessions: Q9BQV0 Q9H2A8 Q9HAP7Alternative splicing: 2 isoforms: Q96CA5-1 Q96CA5-2 Explore the universe of human proteins at neXtProt for BIRC7: NX_Q96CA5
Post-translational modifications:
Autoubiquitinated and undergoes proteasome-mediated degradation1
The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CA5
BIRC7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_071444.1 NP_647478.1
ENSEMBL proteins: ENSP00000345213 ENSP00000217169 ENSP00000378717
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
BIRC7 for ontologies About GeneDecksing
BIRC7 Antibody Products:
Assay Products for BIRC7: |
Protein
Domains /
Families
for BIRC7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BIRC7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96CA5ProtoNet protein and cluster: Q96CA5 2 Blocks protein families: IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR) IPB001841 Zn-finger
UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5Domain: The RING domain is essential for autoubiquitinationSimilarity: Belongs to the IAP familySimilarity: Contains 1 BIR repeatSimilarity: Contains 1 RING-type zinc finger |
Function
for BIRC7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5Function: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles inapoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibitionof CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor,its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it fordegradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability ofDIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemicalagents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation ofMAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocksetoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augmentskillingEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BIRC7 (NM_139317) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIRC7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC7 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
BIRC7 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for BIRC7:
|
Pathways & Interactions
for BIRC7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis and Autophagy | | | 2 | Apoptosis Modulation and Signaling | | | 3 | Apoptosis and survival_Apoptotic TNF-family pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for BIRC7
1 
Cell Signaling Technology (CST) Pathway for BIRC7
1  BioSystems Pathway for BIRC7
BIRC7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIRC7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/17 Interacting proteins for BIRC7 (Q96CA51, 3 ENSP000002171694) via UniProtKB, MINT, STRING, and/or I2D (see all 17)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| DIABLO | Q9NR281, 3, ENSP000002671694 | EBI-517623,EBI-517508 I2D:
score=3 STRING: ENSP00000267169 | | HTRA2 | O434641, 3, ENSP000002580804 | EBI-517623,EBI-517086 I2D:
score=2 STRING: ENSP00000258080 | | CASP9 | P552111, 3, ENSP000003302374 | EBI-517623,EBI-516799 I2D:
score=3 STRING: ENSP00000330237 | | CASP3 | P425743, ENSP000003110324 | I2D:
score=3 STRING: ENSP00000311032 | | XAF1 | Q6GPH43, ENSP000003548224 | I2D:
score=2 STRING: ENSP00000354822 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
BIRC7 for ontologies About GeneDecksing
|
Drugs & Compounds
for BIRC7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BIRC7 for compounds About GeneDecksing
 Browse Tocris compounds for BIRC7
7 Novoseek chemical compound relationships for BIRC7 gene About this table
Search CenterWatch for drugs/clinical trials and news about BIRC7
|
Transcripts
for BIRC7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BIRC7 gene (2 alternative transcripts): NM_022161.2 NM_139317.1 Unigene Cluster for BIRC7: Baculoviral IAP repeat containing 7 Hs.256126 [show with all ESTs]Unigene Representative Sequence: AY3588363 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342412 ENST00000217169(uc010gkc.1 uc002yej.3 uc002yei.3)
ENST00000395306
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BIRC7 (NM_139317) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIRC7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC7 |
Additional cDNA sequence: AF301009.1 AF311388.1 AY358835.1 AY358836.1 AY517497.1 BC014475.1 4 DOTS entries: DT.100741536 DT.100027554 DT.102820976 DT.91800145 24/67 AceView cDNA sequences (see all 67): BM717934 AA379765 BU195879 BQ877438 CD673774 BQ676590 AF301009 BQ892691 BQ682897 BM704611 BM700577 BU172109 BQ682827 NM_139317 NM_022161 BF726384 BQ682378 BC014475 BQ681718 AF311388 CB113932 AY358836 BU737800 AY358835
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC7 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for BIRC7
|
Expression
for BIRC7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BIRC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGCCAGG
About this image
See BIRC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BIRC7
SOURCE GeneReport for Unigene cluster: Hs.256126
UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5Tissue specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues.Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheralblood leukocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including BIRC7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC7
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC7 |
Orthologs
for BIRC7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BIRC7 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BIRC76 |
Uncharacterized protein |
34(a) |
1 ↔ 1 |
20(8709017-8717829) |
lizard
(Anolis carolinensis) |
Reptilia |
BIRC76 |
-- |
22(a) |
1 ↔ 1 |
4(153270174-153278000) |
African clawed frog
(Xenopus laevis) |
Amphibia |
XLX2 |
IAP-like protein |
73.19(n) |
|
AF468029.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
birc76 |
baculoviral IAP repeat-containing 7 |
24(a) |
1 ↔ 1 |
23(14329498-14346904) |
ENSEMBL Gene Tree for BIRC7 (if available)
TreeFam Gene Tree for BIRC7 (if available) |
Paralogs
for BIRC7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BIRC7 gene
- BIRC32 BIRC22 XIAP2 BIRC82
5 SIMAP similar genes for BIRC7 using alignment to 3 protein entries: BIRC7_HUMAN (see all proteins):ILP3 BIRC3 BIRC2 NAIP BIRC5
BIRC7 for paralogs About GeneDecksing
|
Genomic Variants
for BIRC7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BIRC7 (61867235 - 61871859 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for BIRC7
11 CNVs: 5148 5147 31044 59579 50711 53414 53464 59580 30133 30134 50710 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC7 |
|
Disorders
/ Diseases
for BIRC7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BIRC7 for disorders About GeneDecksing
OMIM gene information: 605737
OMIM disorders: --
20/55  diseases for BIRC7 (see all 55): About MalaCardsmelanoma testicular germ cell tumor malignant pleural mesothelioma non-hodgkin lymphoma
bladder transitional cell carcinoma germ cell tumor transitional cell carcinoma squamous cell carcinoma
laryngeal squamous cell carcinoma adenoid cystic carcinoma oral squamous cell carcinoma lymphocytic leukemia
hodgkin's lymphoma pleomorphic adenoma newcastle disease acute lymphoblastic leukemia
chronic lymphocytic leukemia acute lymphocytic leukemia malignant mesothelioma lymphoblastic leukemia
1 disease from the University of Copenhagen DISEASES database for BIRC7:Melanoma 10/15 Novoseek disease relationships for BIRC7 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
50.4 |
28 |
16806840 (4), 14559822 (3), 12626761 (3), 17618569 (2) (see all 14) |
| tumors |
42.6 |
56 |
16328668 (4), 18340356 (4), 17672950 (3), 19914791 (3) (see all 27) |
| cancer |
41.9 |
20 |
19074843 (2), 16026775 (2), 11024045 (2), 20150841 (1) (see all 12) |
| t-all |
34.1 |
2 |
15492285 (1), 15580304 (1) |
| primary tumor |
28.9 |
2 |
18853322 (1), 16328668 (1) |
| leukemia lymphocytic chronic |
28.3 |
1 |
15492285 (1) |
| carcinoma renal cell |
27.7 |
10 |
17656204 (2), 17968430 (2), 17519534 (2), 17437058 (1) (see all 5) |
| nsclc |
27 |
20 |
16965834 (5), 17660948 (2), 18827979 (2), 15541814 (1) (see all 5) |
| solid tumor |
20 |
3 |
18278467 (1), 12488298 (1), 16840203 (1) |
| cancer lung |
17.2 |
9 |
15829321 (2), 16409786 (1), 17660948 (1), 19671483 (1) (see all 6) |
Human Genome Epidemiology (HuGE) Navigator: BIRC7 (1 document)
Export disorders for BIRC7 gene to outside databases
|
Publications
for BIRC7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BIRC7 gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with BIRC7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Livin, a novel inhibitor of apoptosis protein family member. (PubMed id 11024045)1, 2, 3, 9 Kasof G.M. and Gomes B.C. (2001)
- KIAP, a novel member of the inhibitor of apoptosis protein family. (PubMed id 11162435)1, 2, 3, 9 Lin J.H....Morser J. (2000)
- Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. (PubMed id 16729033)1, 2, 9 Ma L....Wu M. (2006)
- Challenge and promise: roles for Livin in progression and therapy of cancer. (PubMed id 19074843)1, 2, 9 Wang L....Shan B. (2008)
- Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. (PubMed id 17294084)1, 2, 9 Nachmias B....Ben-Yehuda D. (2007)
- Manipulation of NK cytotoxicity by the IAP family member Livin. (PubMed id 18034418)1, 2, 9 Nachmias B....Mandelboim O. (2007)
- Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. (PubMed id 11322947)1, 2, 9 Ashhab Y.... Yehuda D.B. (2001)
- Research progress on Livin protein: an inhibitor of apoptosis. (PubMed id 21617971)1, 2 Yan B. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
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External Searches for BIRC7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing BIRC7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing BIRC7 gene
(According to HUGE)
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Specialized Databases showing BIRC7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for BIRC7 gene:
Search GeneIP for patents involving BIRC7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for BIRC7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for BIRC7 | | OriGene shRNA RFP for BIRC7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIRC7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC7 | | | OriGene Protein Over-expression Lysate for BIRC7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BIRC7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BIRC7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BIRC7 | | OriGene Custom Protein Services for BIRC7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BIRC7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC7 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC7 |
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| | Antibodies & Assays for BIRC7 |
| | | | Search Tocris compounds for BIRC7 |
| |  |  |  |  | | | | | | Recombinant Protein for BIRC7 |
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 | | | BIRC7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC7 |
|  |  |  | | | | ThermoFisher Antibody for BIRC7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC7 |
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