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Aliases for BIRC7 Gene

Aliases for BIRC7 Gene

  • Baculoviral IAP Repeat Containing 7 2 3
  • Melanoma Inhibitor Of Apoptosis Protein 2 3 4
  • Kidney Inhibitor Of Apoptosis Protein 2 3 4
  • LIVIN 3 4 6
  • MLIAP 3 4 6
  • KIAP 3 4 6
  • RING Finger Protein 50 3 4
  • ML-IAP 3 4
  • RNF50 3 4
  • Baculoviral IAP Repeat-Containing Protein 7 3
  • Baculoviral IAP Repeat-Containing 7 2
  • Livin Inhibitor-Of-Apoptosis 2
  • Livin Inhibitor Of Apoptosis 3
  • EC 6.3.2.- 4
  • Livin 2

External Ids for BIRC7 Gene

Summaries for BIRC7 Gene

Entrez Gene Summary for BIRC7 Gene

  • This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

GeneCards Summary for BIRC7 Gene

BIRC7 (Baculoviral IAP Repeat Containing 7) is a Protein Coding gene. Diseases associated with BIRC7 include melanoma and malignant pleural mesothelioma. Among its related pathways are Pathways in cancer and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC7 Gene

  • Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Gene Wiki entry for BIRC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC7 Gene

Genomics for BIRC7 Gene

Genomic Location for BIRC7 Gene

Start:
63,235,883 bp from pter
End:
63,240,507 bp from pter
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for BIRC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC7 Gene

Regulatory Elements for BIRC7 Gene

Proteins for BIRC7 Gene

  • Protein details for BIRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CA5-BIRC7_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 7
    Protein Accession:
    Q96CA5
    Secondary Accessions:
    • Q9BQV0
    • Q9H2A8
    • Q9HAP7

    Protein attributes for BIRC7 Gene

    Size:
    298 amino acids
    Molecular mass:
    32798 Da
    Quaternary structure:
    • Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain.

    Three dimensional structures from OCA and Proteopedia for BIRC7 Gene

    Alternative splice isoforms for BIRC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC7 Gene

Proteomics data for BIRC7 Gene at MOPED

Post-translational modifications for BIRC7 Gene

  • Autoubiquitinated and undergoes proteasome-mediated degradation
  • The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIRC7 Gene

No data available for DME Specific Peptides for BIRC7 Gene

Domains for BIRC7 Gene

Gene Families for BIRC7 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • BIRC :Baculoviral IAP repeat containing

UniProtKB/Swiss-Prot:

BIRC7_HUMAN
Domain:
  • The RING domain is essential for autoubiquitination:
    • Q96CA5
Family:
  • Belongs to the IAP family.:
    • Q96CA5
Similarity:
  • Contains 1 BIR repeat.:
    • Q96CA5
  • Contains 1 RING-type zinc finger.:
    • Q96CA5
genes like me logo Genes that share domains with BIRC7: view

Function for BIRC7 Gene

Molecular function for BIRC7 Gene

UniProtKB/Swiss-Prot Function: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Enzyme Numbers (IUBMB) for BIRC7 Gene

Gene Ontology (GO) - Molecular Function for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16729033
GO:0004869 cysteine-type endopeptidase inhibitor activity TAS 21617971
GO:0005515 protein binding IPI 11024045
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with BIRC7: view

Phenotypes for BIRC7 Gene

GenomeRNAi human phenotypes for BIRC7:
genes like me logo Genes that share phenotypes with BIRC7: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BIRC7 Gene

Localization for BIRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC7 Gene

Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC7 Gene COMPARTMENTS Subcellular localization image for BIRC7 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17294084
GO:0005737 cytoplasm IDA 17294084
GO:0005794 Golgi apparatus IDA 17294084
GO:0005876 NOT spindle microtubule IBA --
genes like me logo Genes that share ontologies with BIRC7: view

Pathways for BIRC7 Gene

genes like me logo Genes that share pathways with BIRC7: view

Pathways by source for BIRC7 Gene

1 R&D Systems pathway for BIRC7 Gene
1 Cell Signaling Technology pathway for BIRC7 Gene

Gene Ontology (GO) - Biological Process for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0007257 activation of JUN kinase activity NAS 11865055
GO:0009966 regulation of signal transduction IBA --
GO:0010951 negative regulation of endopeptidase activity --
GO:0016567 protein ubiquitination IDA 16729033
genes like me logo Genes that share ontologies with BIRC7: view

Compounds for BIRC7 Gene

(7) Novoseek inferred chemical compound relationships for BIRC7 Gene

Compound -log(P) Hits PubMed IDs
ciap2 85.9 4
ciap1 85.1 4
etoposide 45.6 5
cisplatin 44.8 2
doxorubicin 27.4 1
genes like me logo Genes that share compounds with BIRC7: view

Transcripts for BIRC7 Gene

Unigene Clusters for BIRC7 Gene

Baculoviral IAP repeat containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BIRC7 Gene

GeneLoc Exon Structure for
BIRC7
ECgene alternative splicing isoforms for
BIRC7

Expression for BIRC7 Gene

mRNA expression in normal human tissues for BIRC7 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC7 Gene

This gene is overexpressed in Nerve - Tibial (28.2).

SOURCE GeneReport for Unigene cluster for BIRC7 Gene Hs.256126

mRNA Expression by UniProt/SwissProt for BIRC7 Gene

Q96CA5-BIRC7_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes
genes like me logo Genes that share expressions with BIRC7: view

Orthologs for BIRC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC7 36
  • 93.22 (n)
  • 91.23 (a)
BIRC7 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BIRC7 36
  • 78.66 (n)
  • 71.63 (a)
BIRC7 37
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC7 36
  • 73.47 (n)
  • 67.96 (a)
BIRC7 37
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc7 36
  • 76.01 (n)
  • 70.11 (a)
Birc7 16
Birc7 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BIRC7 37
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC7 37
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves BIRC7 37
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIRC7 37
  • 25 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XLX 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3444 36
zebrafish
(Danio rerio)
Actinopterygii birc7 37
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Iap2 37
  • 17 (a)
ManyToMany
th 37
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 7 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 5 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 13 (a)
ManyToMany
Species with no ortholog for BIRC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC7 Gene

ENSEMBL:
Gene Tree for BIRC7 (if available)
TreeFam:
Gene Tree for BIRC7 (if available)

Paralogs for BIRC7 Gene

Paralogs for BIRC7 Gene

Selected SIMAP similar genes for BIRC7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BIRC7: view

Variants for BIRC7 Gene

Sequence variations from dbSNP and Humsavar for BIRC7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs911061 -- 63,234,319(+) TGGGC(A/G)CTGGA upstream-variant-2KB
rs1077019 - 63,239,375(-) GGCCT(C/G)GGCTG intron-variant, missense, reference
rs2015701 -- 63,234,355(-) TCCAG(C/T)GCCCA upstream-variant-2KB
rs2015710 -- 63,234,303(+) ggggg(C/T)gaagg upstream-variant-2KB
rs2015711 -- 63,234,295(+) gacag(A/G)gaggg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BIRC7 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
nsv834031 CNV Loss 17160897
dgv519n27 CNV Loss 19166990
dgv4626n71 CNV Loss 21882294
dgv4627n71 CNV Loss 21882294
dgv4628n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897
dgv520n27 CNV Loss 19166990
nsv517648 CNV Loss 19592680
nsv819591 CNV Gain 19587683
nsv518905 CNV Loss 19592680
nsv470560 CNV Loss 18288195
nsv525279 CNV Loss 19592680
nsv913177 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
nsv913180 CNV Loss 21882294
nsv820146 CNV Gain 19587683
nsv3446 CNV Loss 18451855
nsv522880 CNV Loss 19592680

Relevant External Links for BIRC7 Gene

HapMap Linkage Disequilibrium report
BIRC7

Disorders for BIRC7 Gene

(1) University of Copenhagen DISEASES for BIRC7 Gene

(15) Novoseek inferred disease relationships for BIRC7 Gene

Disease -log(P) Hits PubMed IDs
melanoma 50.4 25
tumors 42.6 43
cancer 41.9 15
t-all 34.1 2
primary tumor 28.9 2

Relevant External Links for BIRC7

Human Genome Epidemiology (HuGE) Navigator
BIRC7
genes like me logo Genes that share disorders with BIRC7: view

No data available for UniProtKB/Swiss-Prot for BIRC7 Gene

Publications for BIRC7 Gene

  1. Livin, a novel inhibitor of apoptosis protein family member. (PMID: 11024045) Kasof G.M. … Gomes B.C. (J. Biol. Chem. 2001) 2 3 4 23
  2. KIAP, a novel member of the inhibitor of apoptosis protein family. (PMID: 11162435) Lin J.-H. … Morser J. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  3. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. (PMID: 11322947) Ashhab Y. … Yehuda D.B. (FEBS Lett. 2001) 3 4 23
  4. Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. (PMID: 16729033) Ma L. … Wu M. (Cell Death Differ. 2006) 3 4 23
  5. Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. (PMID: 17294084) Nachmias B. … Ben-Yehuda D. (Apoptosis 2007) 3 4 23

Products for BIRC7 Gene

Sources for BIRC7 Gene

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