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Aliases for BIRC7 Gene

Aliases for BIRC7 Gene

  • Baculoviral IAP Repeat Containing 7 2 3 5
  • Melanoma Inhibitor Of Apoptosis Protein 2 3 4
  • Kidney Inhibitor Of Apoptosis Protein 2 3 4
  • RING Finger Protein 50 3 4
  • ML-IAP 3 4
  • LIVIN 3 4
  • MLIAP 3 4
  • RNF50 3 4
  • KIAP 3 4
  • Baculoviral IAP Repeat-Containing 7 2
  • Livin Inhibitor-Of-Apoptosis 2
  • Livin Inhibitor Of Apoptosis 3
  • EC 6.3.2.- 4
  • Livin 2

External Ids for BIRC7 Gene

Previous GeneCards Identifiers for BIRC7 Gene

  • GC20P061744
  • GC20P062546
  • GC20P062593
  • GC20P061337
  • GC20P061867
  • GC20P058592

Summaries for BIRC7 Gene

Entrez Gene Summary for BIRC7 Gene

  • This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

GeneCards Summary for BIRC7 Gene

BIRC7 (Baculoviral IAP Repeat Containing 7) is a Protein Coding gene. Diseases associated with BIRC7 include Lung Cancer. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Pathways in cancer. GO annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC7 Gene

  • Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Gene Wiki entry for BIRC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC7 Gene

Genomics for BIRC7 Gene

Regulatory Elements for BIRC7 Gene

Enhancers for BIRC7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BIRC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for BIRC7 Gene

Chromosome:
20
Start:
63,235,883 bp from pter
End:
63,240,507 bp from pter
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for BIRC7 Gene

Genes around BIRC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC7 Gene

Proteins for BIRC7 Gene

  • Protein details for BIRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CA5-BIRC7_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 7
    Protein Accession:
    Q96CA5
    Secondary Accessions:
    • Q9BQV0
    • Q9H2A8
    • Q9HAP7

    Protein attributes for BIRC7 Gene

    Size:
    298 amino acids
    Molecular mass:
    32798 Da
    Quaternary structure:
    • Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain.

    Three dimensional structures from OCA and Proteopedia for BIRC7 Gene

    Alternative splice isoforms for BIRC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC7 Gene

Proteomics data for BIRC7 Gene at MOPED

Post-translational modifications for BIRC7 Gene

  • Autoubiquitinated and undergoes proteasome-mediated degradation.
  • The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIRC7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BIRC7 (BIRC7)

No data available for DME Specific Peptides for BIRC7 Gene

Domains & Families for BIRC7 Gene

Suggested Antigen Peptide Sequences for BIRC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CA5

UniProtKB/Swiss-Prot:

BIRC7_HUMAN :
  • The RING domain is essential for autoubiquitination.
  • Belongs to the IAP family.
  • Contains 1 BIR repeat.
Domain:
  • The RING domain is essential for autoubiquitination.
Family:
  • Belongs to the IAP family.
Similarity:
  • Contains 1 BIR repeat.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with BIRC7: view

Function for BIRC7 Gene

Molecular function for BIRC7 Gene

UniProtKB/Swiss-Prot Function:
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Enzyme Numbers (IUBMB) for BIRC7 Gene

Gene Ontology (GO) - Molecular Function for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16729033
GO:0005515 protein binding IEA,IPI 11024045
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with BIRC7: view
genes like me logo Genes that share phenotypes with BIRC7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BIRC7

miRNA for BIRC7 Gene

miRTarBase miRNAs that target BIRC7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BIRC7 Gene

Localization for BIRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC7 Gene

Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC7 Gene COMPARTMENTS Subcellular localization image for BIRC7 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytoskeleton 3
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17294084
GO:0005876 spindle microtubule IBA --
genes like me logo Genes that share ontologies with BIRC7: view

Pathways & Interactions for BIRC7 Gene

genes like me logo Genes that share pathways with BIRC7: view

Pathways by source for BIRC7 Gene

1 Cell Signaling Technology pathway for BIRC7 Gene
1 BioSystems pathway for BIRC7 Gene

SIGNOR curated interactions for BIRC7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IBA --
GO:0016567 protein ubiquitination IDA 16729033
GO:0042127 regulation of cell proliferation IDA 21617971
GO:0043066 negative regulation of apoptotic process NAS 11162435
GO:0070247 regulation of natural killer cell apoptotic process IDA 18034418
genes like me logo Genes that share ontologies with BIRC7: view

Drugs & Compounds for BIRC7 Gene

(7) Drugs for BIRC7 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LCL161 Pharma Antagonist of IAPs inhibitor, Inhibitor of apoptosis proteins (IAPS) antagonist 0
AT-406 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
GDC-0152 Pharma IAP antagonist,potent amd samll-molecule 0

(3) Additional Compounds for BIRC7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for BIRC7 Gene

Compound Action Cas Number
LCL161 Antagonist of IAPs inhibitor 1005342-46-0
genes like me logo Genes that share compounds with BIRC7: view

Transcripts for BIRC7 Gene

Unigene Clusters for BIRC7 Gene

Baculoviral IAP repeat containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BIRC7 Gene

GeneLoc Exon Structure for
BIRC7
ECgene alternative splicing isoforms for
BIRC7

Expression for BIRC7 Gene

mRNA expression in normal human tissues for BIRC7 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC7 Gene

This gene is overexpressed in Nerve - Tibial (x28.2).

SOURCE GeneReport for Unigene cluster for BIRC7 Gene Hs.256126

mRNA Expression by UniProt/SwissProt for BIRC7 Gene

Q96CA5-BIRC7_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with BIRC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BIRC7 Gene

Orthologs for BIRC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BIRC7 35
  • 78.66 (n)
  • 71.63 (a)
BIRC7 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC7 35
  • 73.47 (n)
  • 67.96 (a)
BIRC7 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc7 35
  • 76.01 (n)
  • 70.11 (a)
Birc7 16
Birc7 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIRC7 35
  • 93.22 (n)
  • 91.23 (a)
BIRC7 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BIRC7 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC7 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves BIRC7 36
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIRC7 36
  • 25 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3444 35
African clawed frog
(Xenopus laevis)
Amphibia XLX 35
zebrafish
(Danio rerio)
Actinopterygii birc7 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Iap2 36
  • 17 (a)
ManyToMany
th 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 5 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
Species with no ortholog for BIRC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC7 Gene

ENSEMBL:
Gene Tree for BIRC7 (if available)
TreeFam:
Gene Tree for BIRC7 (if available)

Paralogs for BIRC7 Gene

Paralogs for BIRC7 Gene

(4) SIMAP similar genes for BIRC7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BIRC7: view

Variants for BIRC7 Gene

Sequence variations from dbSNP and Humsavar for BIRC7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1077019 - 63,239,375(-) GGCCT(C/G/T)GGCTG intron-variant, reference, missense
rs911061 -- 63,234,319(+) TGGGC(A/G)CTGGA upstream-variant-2KB
rs2015701 -- 63,234,355(-) TCCAG(C/T)GCCCA upstream-variant-2KB
rs2015710 -- 63,234,303(+) ggggg(C/T)gaagg upstream-variant-2KB
rs2015711 -- 63,234,295(+) gacag(A/G)gaggg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BIRC7 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
nsv834031 CNV Loss 17160897
dgv519n27 CNV Loss 19166990
dgv4626n71 CNV Loss 21882294
dgv4627n71 CNV Loss 21882294
dgv4628n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897
dgv520n27 CNV Loss 19166990
nsv517648 CNV Loss 19592680
nsv819591 CNV Gain 19587683
nsv518905 CNV Loss 19592680
nsv470560 CNV Loss 18288195
nsv525279 CNV Loss 19592680
nsv913177 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
nsv913180 CNV Loss 21882294
nsv820146 CNV Gain 19587683
nsv3446 CNV Loss 18451855
nsv522880 CNV Loss 19592680

Variation tolerance for BIRC7 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BIRC7 Gene

Disorders for BIRC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BIRC7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search BIRC7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BIRC7

Human Genome Epidemiology (HuGE) Navigator
BIRC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIRC7
genes like me logo Genes that share disorders with BIRC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC7 Gene

Publications for BIRC7 Gene

  1. Livin, a novel inhibitor of apoptosis protein family member. (PMID: 11024045) Kasof G.M. … Gomes B.C. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. KIAP, a novel member of the inhibitor of apoptosis protein family. (PMID: 11162435) Lin J.-H. … Morser J. (Biochem. Biophys. Res. Commun. 2000) 2 3 23
  3. Expression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNA-mediated silencing of livin gene. (PMID: 19914791) Wang T.S. … Liu P. (Biomed. Pharmacother. 2010) 3 23
  4. Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. (PMID: 20109966) Yang Y.L. … Lin D.T. (Leuk. Res. 2010) 3 23
  5. Influence of Etoposide on anti-apoptotic and multidrug resistance-associated protein genes in CD133 positive U251 glioblastoma stem-like cells. (PMID: 20388502) Jin F. … Zhao H.Y. (Brain Res. 2010) 3 23

Products for BIRC7 Gene

Sources for BIRC7 Gene

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