Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BIRC7 Gene

protein-coding   GIFtS: 61
GCID: GC20P061867

Baculoviral IAP Repeat Containing 7

(Previous name: baculoviral IAP repeat-containing 7)
  See BIRC7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Baculoviral IAP Repeat Containing 71 2     RING Finger Protein 502 3
Kidney Inhibitor Of Apoptosis Protein1 2 3     Baculoviral IAP Repeat-Containing 71
Melanoma Inhibitor Of Apoptosis Protein1 2 3     livin1
KIAP2 3 5     Livin Inhibitor-Of-Apoptosis1
LIVIN2 3 5     Baculoviral IAP Repeat-Containing Protein 72
MLIAP2 3 5     Livin Inhibitor Of Apoptosis2
ML-IAP2 3     EC 6.3.2.-3
RNF502 3     Livin3

External Ids:    HGNC: 137021   Entrez Gene: 794442   Ensembl: ENSG000001011977   OMIM: 6057375   UniProtKB: Q96CA53   

Export aliases for BIRC7 gene to outside databases

Previous GC identifers: GC20P061744 GC20P062546 GC20P062593 GC20P061337 GC20P058592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BIRC7 Gene:
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a
baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for
inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic
activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with
cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple
transcript variants (provided by RefSeq, Jul 2013)

GeneCards Summary for BIRC7 Gene:
BIRC7 (baculoviral IAP repeat containing 7) is a protein-coding gene. Diseases associated with BIRC7 include malignant pleural mesothelioma, and adenoid cystic carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5
Function: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial
roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through
the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak
caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC
targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking
the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF
or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by
activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In
vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis.
Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas
isoform 1 augments killing

Gene Wiki entry for BIRC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the BIRC7 gene promoter:
         N-Myc   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBIRC7 promoter sequence
   Search Chromatin IP Primers for BIRC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIRC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

BIRC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC7 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061867:  view genomic region     (about GC identifiers)

Start:
61,867,235 bp from pter      End:
61,871,859 bp from pter
Size:
4,625 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 7  
Size: 298 amino acids; 32798 Da
Subunit: Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic
suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain
Selected PDB 3D structures from and Proteopedia for BIRC7 (see all 13):
1OXN (3D)        1OXQ (3D)        1OY7 (3D)        1TW6 (3D)        2I3H (3D)        2I3I (3D)    
Secondary accessions: Q9BQV0 Q9H2A8 Q9HAP7
Alternative splicing: 2 isoforms:  Q96CA5-1   Q96CA5-2   

Explore the universe of human proteins at neXtProt for BIRC7: NX_Q96CA5

Explore proteomics data for BIRC7 at MOPED

Post-translational modifications: 

  • Autoubiquitinated and undergoes proteasome-mediated degradation1
  • The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BIRC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_071444.1  NP_647478.1  

    ENSEMBL proteins: 
     ENSP00000345213   ENSP00000217169   ENSP00000378717  

    BIRC7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BIRC7 (Livin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BIRC7
    OriGene Protein Over-expression Lysate for BIRC7
    OriGene MassSpec for BIRC7
    OriGene Custom Protein Services for BIRC7
    GenScript Custom Purified and Recombinant Proteins Services for BIRC7
    Novus Biologicals BIRC7 Proteins
    Novus Biologicals BIRC7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BIRC7
    Cloud-Clone Corp. Proteins for BIRC7

     
    Search eBioscience for Proteins for BIRC7 

    BIRC7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BIRC7
    R&D Systems Antibodies for BIRC7 (Livin)
    Cell Signaling Technology (CST) Antibodies for BIRC7 
    OriGene Antibodies for BIRC7
    OriGene Custom Antibody Services for BIRC7
    Novus Biologicals BIRC7 Antibodies
    Abcam antibodies for BIRC7
    Cloud-Clone Corp. Antibodies for BIRC7
    ThermoFisher Antibody for BIRC7
    LSBio Antibodies in human, mouse, rat for BIRC7

    BIRC7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BIRC7
    R&D Systems Proteome Profiler Antibody Arrays for BIRC7 (Livin)
    GenScript Custom Assay Services for BIRC7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BIRC7
    Cloud-Clone Corp. CLIAs for BIRC7
    Search eBioscience for ELISAs for BIRC7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BIRC: Baculoviral IAP repeat containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR001370 BIR

    Graphical View of Domain Structure for InterPro Entry Q96CA5

    ProtoNet protein and cluster: Q96CA5

    2 Blocks protein domains:
    IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5
    Domain: The RING domain is essential for autoubiquitination
    Similarity: Belongs to the IAP family
    Similarity: Contains 1 BIR repeat
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with BIRC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC7_HUMAN, Q96CA5
    Function: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial
    roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through
    the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak
    caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC
    targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking
    the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF
    or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by
    activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In
    vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis.
    Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas
    isoform 1 augments killing

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA16729033
    GO:0004869cysteine-type endopeptidase inhibitor activity TAS--
    GO:0005515protein binding IPI11024045
    GO:0008270zinc ion binding IEA--
    GO:0019899enzyme binding NAS11801603
         
    Find genes that share ontologies with BIRC7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BIRC7:
     Increased gamma-H2AX phosphory  Lamellipodia cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIRC7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIRC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIRC7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIRC7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BIRC7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BIRC7
    SwitchGear 3'UTR luciferase reporter plasmidBIRC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BIRC7
    Search Predesigned siRNA for gene silencing in human, mouse, rat BIRC7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BIRC7

    Clone
    Products:
         
    OriGene clones in human, mouse for BIRC7 (see all 9)
    OriGene ORF clones in mouse, rat for BIRC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BIRC7 (NM_139317)
    Sino Biological Human cDNA Clone for BIRC7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BIRC7
    Browse ESI BIO Cell Lines and PureStem Progenitors for BIRC7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BIRC7_HUMAN, Q96CA5: Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout
    the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is
    found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in
    the nucleus shows positive correlation with the increase in apoptosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17294084
    GO:0005737cytoplasm IDA17294084
    GO:0005794Golgi apparatus IDA17294084

    Find genes that share ontologies with BIRC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BIRC7 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    2Apoptosis (KEGG)
    Apoptosis0.37
    3Leishmaniasis
    Toxoplasmosis0.35
    4Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35
    5Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with BIRC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BIRC7
        Apoptosis Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for BIRC7
        Apoptosis and Autophagy

    1 BioSystems Pathway for BIRC7
        Apoptosis Modulation and Signaling



    5 Kegg Pathways  (Kegg details for BIRC7):
        Ubiquitin mediated proteolysis
    Apoptosis
    Toxoplasmosis
    Pathways in cancer
    Small cell lung cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC7: 
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BIRC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIRC7 (Q96CA51, 3 ENSP000002171694) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIABLOQ9NR281, 3, ENSP000002671694EBI-517623,EBI-517508 I2D: score=3 STRING: ENSP00000267169
    HTRA2O434641, 3, ENSP000002580804EBI-517623,EBI-517086 I2D: score=2 STRING: ENSP00000258080
    CASP9P552111, 3, ENSP000003302374EBI-517623,EBI-516799 I2D: score=3 STRING: ENSP00000330237
    CASP3P425743, ENSP000003110324I2D: score=3 STRING: ENSP00000311032
    XAF1Q6GPH43, ENSP000003548224I2D: score=2 STRING: ENSP00000354822
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006309apoptotic DNA fragmentation ----
    GO:0006915apoptotic process IEA--
    GO:0007257activation of JUN kinase activity NAS11865055
    GO:0010951negative regulation of endopeptidase activity TAS--
    GO:0016567protein ubiquitination IDA16729033

    Find genes that share ontologies with BIRC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIRC7

    7 Novoseek inferred chemical compound relationships for BIRC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap2 85.9 4 19269012 (2), 16892011 (1), 16957584 (1)
    ciap1 85.1 4 19269012 (2), 16892011 (1), 16957584 (1)
    etoposide 45.6 6 17437058 (1), 11162435 (1), 16965834 (1), 20171199 (1) (see all 5)
    cisplatin 44.8 2 16806840 (2)
    doxorubicin 27.4 1 14614456 (1)
    5fluorouracil 0 1 17437058 (1)
    serine 0 2 16806840 (1), 16038965 (1)



    Find genes that share compounds with BIRC7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BIRC7 gene (2 alternative transcripts): 
    NM_022161.3  NM_139317.2  

    Unigene Cluster for BIRC7:

    Baculoviral IAP repeat containing 7
    Hs.256126  [show with all ESTs]
    Unigene Representative Sequence: AY358836
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342412 ENST00000217169(uc010gkc.1 uc002yej.3 uc002yei.3)
    ENST00000395306
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BIRC7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BIRC7
    SwitchGear 3'UTR luciferase reporter plasmidBIRC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BIRC7
    Search Predesigned siRNA for gene silencing in human, mouse, rat BIRC7
    Clone
    Products:
         
    OriGene clones in human, mouse for BIRC7 (see all 9)
    OriGene ORF clones in mouse, rat for BIRC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BIRC7 (NM_139317)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BIRC7
    OriGene qSTAR qPCR primer pairs in human, mouse for BIRC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIRC7
      QuantiTect SYBR Green Assays in human, mouse, rat BIRC7
      QuantiFast Probe-based Assays in human, mouse, rat BIRC7

    Additional mRNA sequence: 

    AF301009.1 AF311388.1 AY358835.1 AY358836.1 AY517497.1 BC014475.1 

    4 DOTS entries:

    DT.100741536  DT.100027554  DT.102820976  DT.91800145 

    Selected AceView cDNA sequences (see all 67):

    CD673774 BM717934 BU195879 BQ681718 NM_139317 BQ682378 BM700577 BU737800 
    BQ877438 BU180020 BC014475 BM704611 AF301009 CB113932 BQ892691 BQ676590 
    AA379765 AY358836 BQ682827 AY358835 BU172109 BQ682897 BF726384 NM_022161 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BIRC7 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
    SP1:              -           -                                                               
    SP2:              -           -                             -     -                           
    SP3:              -           -                                                               
    SP4:                          -                             -     -                           
    SP5:                                                        -     -                           


    ECgene alternative splicing isoforms for BIRC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BIRC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGGCCAGG
    BIRC7 Expression
    About this image

    BIRC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIRC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256126

    UniProtKB/Swiss-Prot: BIRC7_HUMAN, Q96CA5
    Tissue specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult
    tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell
    lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal
    muscle and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC7: 
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BIRC7
    OriGene qSTAR qPCR primer pairs in human, mouse for BIRC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIRC7
    QuantiTect SYBR Green Assays in human, mouse, rat BIRC7
    QuantiFast Probe-based Assays in human, mouse, rat BIRC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BIRC7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Birc71 , 5 baculoviral IAP repeat-containing 7 (livin)1, 5 76.01(n)1
    70.11(a)1
      2 (103.53 cM)5
    3295811  NM_001163247.11  NP_001156719.11 
     1809290235 
    chicken
    (Gallus gallus)
    Aves BIRC76
    baculoviral IAP repeat containing 7
    26(a)
    1 ↔ 1
    20(9069124-9075710)
    lizard
    (Anolis carolinensis)
    Reptilia BIRC76
    baculoviral IAP repeat containing 7
    25(a)
    1 ↔ 1
    4(153270174-153278000)
    African clawed frog
    (Xenopus laevis)
    Amphibia XLX2 IAP-like protein 73.19(n)    AF468029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii birc76
    baculoviral IAP repeat-containing 7
    29(a)
    1 ↔ 1
    23(14329498-14346904) ENSDARG00000058082
    fruit fly
    (Drosophila melanogaster)
    Insecta th6
    Iap26
    Inhibitor of apoptosis 2
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    3L(16031510-16044134)
    2R(11819675-11822330)


    ENSEMBL Gene Tree for BIRC7 (if available)
    TreeFam Gene Tree for BIRC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BIRC7 gene
    BIRC32  NLRC42  NAIP2  BIRC22  XIAP2  BIRC82  
    4 SIMAP similar genes for BIRC7 using alignment to 3 protein entries:     BIRC7_HUMAN (see all proteins):
    ILP3    BIRC2    NAIP    BIRC5

    Find genes that share paralogs with BIRC7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BIRC7 (see all 238)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798673961,2
    C,F--61824442(+) ACACCC/TGGGGT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs119078871,2
    C,F,H--61824451(+) GTTTTG/ACTGAA 2 -- us2k18Minor allele frequency- A:0.06NS EA WA NA CSA 533
    rs119055921,2
    C,F,H--61824488(+) gggggC/Tggtgg 2 -- us2k14Minor allele frequency- T:0.21WA NA CSA 123
    rs23142491,2
    C--61824579(+) GGGGCG/AAAGGT 2 -- us2k15Minor allele frequency- A:0.14NA WA EA 362
    rs1403231991,2
    --61824593(+) GTGGAC/TGCTGG 2 -- us2k10--------
    rs1509928361,2
    C--61824606(+) GACAGA/GGAGGG 2 -- us2k10--------
    rs1503679411,2
    C--61824611(+) AGAGGC/GGGCAA 2 -- us2k10--------
    rs23142501,2
    C,F,A--61824615(+) GGGGCA/GAAGGC 2 -- us2k15Minor allele frequency- G:0.25NA WA 126
    rs20157111,2
    C,F,A--61824642(+) gacagA/Ggaggg 2 -- us2k1 trp33Minor allele frequency- G:0.33NA 6
    rs20157101,2
    C,F,A--61824650(+) gggggC/Tgaagg 2 -- us2k14Minor allele frequency- T:0.25NA WA 8

    HapMap Linkage Disequilibrium report for BIRC7 (61867235 - 61871859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BIRC7 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522880CNV Loss19592680
    dgv4627n71CNV Loss21882294
    nsv913165CNV Loss21882294
    dgv4618n71CNV Loss21882294
    nsv517648CNV Loss19592680
    nsv834031CNV Loss17160897
    dgv4626n71CNV Loss21882294
    nsv3446CNV Loss18451855
    dgv4629n71CNV Loss21882294
    nsv913177CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIRC7
    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605737    OMIM disorders: --

    3 diseases for BIRC7:    
    About MalaCards
    malignant pleural mesothelioma    adenoid cystic carcinoma    melanoma

    1 disease from the University of Copenhagen DISEASES database for BIRC7:
    Melanoma

    Find genes that share disorders with BIRC7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BIRC7 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 50.4 28 16806840 (4), 14559822 (3), 12626761 (3), 17618569 (2) (see all 14)
    tumors 42.6 56 16328668 (4), 18340356 (4), 17672950 (3), 19914791 (3) (see all 27)
    cancer 41.9 20 19074843 (2), 16026775 (2), 11024045 (2), 20150841 (1) (see all 12)
    t-all 34.1 2 15492285 (1), 15580304 (1)
    primary tumor 28.9 2 18853322 (1), 16328668 (1)
    leukemia lymphocytic chronic 28.3 1 15492285 (1)
    carcinoma renal cell 27.7 10 17656204 (2), 17968430 (2), 17519534 (2), 17437058 (1) (see all 5)
    nsclc 27 20 16965834 (5), 17660948 (2), 18827979 (2), 15541814 (1) (see all 5)
    solid tumor 20 3 18278467 (1), 12488298 (1), 16840203 (1)
    cancer lung 17.2 9 15829321 (2), 16409786 (1), 17660948 (1), 19671483 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: BIRC7 (1 document)

    Export disorders for BIRC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BIRC7 gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with BIRC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Livin, a novel inhibitor of apoptosis protein family member. (PubMed id 11024045)1, 2, 3, 9 Kasof G.M. and Gomes B.C. (J. Biol. Chem. 2001)
    2. KIAP, a novel member of the inhibitor of apoptosis protein family. (PubMed id 11162435)1, 2, 3, 9 Lin J.-H.... Morser J. (Biochem. Biophys. Res. Commun. 2000)
    3. Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. (PubMed id 16729033)1, 2, 9 Ma L....Wu M. (Cell Death Differ. 2006)
    4. Challenge and promise: roles for Livin in progression and therapy of cancer. (PubMed id 19074843)1, 2, 9 Wang L.... Shan B. (Mol. Cancer Ther. 2008)
    5. Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. (PubMed id 17294084)1, 2, 9 Nachmias B.... Ben-Yehuda D. (Apoptosis 2007)
    6. Manipulation of NK cytotoxicity by the IAP family member Livin. (PubMed id 18034418)1, 2, 9 Nachmias B.... Mandelboim O. (Eur. J. Immunol. 2007)
    7. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. (PubMed id 11322947)1, 2, 9 Ashhab Y.... Yehuda D.B. (FEBS Lett. 2001)
    8. Research progress on Livin protein: an inhibitor of apoptosis. (PubMed id 21617971)1, 2 Yan B. (Mol. Cell. Biochem. 2011)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79444 HGNC: 13702 AceView: BIRC7 Ensembl:ENSG00000101197 euGenes: HUgn79444
    ECgene: BIRC7 Kegg: 79444 H-InvDB: BIRC7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BIRC7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BIRC7 gene:
    Search GeneIP for patents involving BIRC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BIRC7
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for BIRC7 (Livin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for BIRC7 (Livin)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for BIRC7 (Livin)  
     OriGene Antibodies for BIRC7   OriGene RNAi products in human, mouse, rat for BIRC7  
     OriGene qPCR primer pairs and template standards for BIRC7   OriGene Protein Over-expression Lysate for BIRC7  
     OriGene MassSpec something-or-other for BIRC7   OriGene clones in human, mouse for BIRC7  
     OriGene qSTAR qPCR primer pairs in human, mouse for BIRC7   OriGene Purified Protein for BIRC7  
     OriGene ORF clones in mouse, rat for BIRC7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BIRC7   OriGene Custom Protein Services for BIRC7  

     
     
     Block miRNA regulation of human, mouse, rat BIRC7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BIRC7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIRC7 Search Predesigned siRNA for gene silencing in human, mouse, rat BIRC7
     QuantiFast Probe-based Assays in human, mouse, rat BIRC7 QuantiTect SYBR Green Assays in human, mouse, rat BIRC7
     PCR Arrays including human, mouse, rat BIRC7 Search Chromatin IP Primers for BIRC7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIRC7  GeneGlobe Interaction Network for BIRC7
     Regulatory tfbs in BIRC7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BIRC7 GenScript cDNA clones with any tag delivered in your preferred vector for BIRC7
     GenScript Custom Assay Services for BIRC7 GenScript Custom overexpressing Cell Line Services for BIRC7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for BIRC7 

     Search Tocris compounds for BIRC7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BIRC7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BIRC7 antibodies
     BIRC7 proteins
     BIRC7 lysates
     Antibodies for BIRC7
     See all of Abcam's Antibodies, Kits and Proteins for BIRC7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BIRC7
     Proteins for BIRC7
     Antibodies for BIRC7
     ELISAs for BIRC7
     CLIAs for BIRC7



     Browse ESI BIO Cell Lines and PureStem Progenitors for BIRC7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC7
     SwitchGear 3'UTR luciferase reporter plasmids for BIRC7
     SwitchGear Promoter luciferase reporter plasmids for BIRC7
     ThermoFisher Antibody for BIRC7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIRC7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIRC7
     LSBio Antibodies in human, mouse, rat for BIRC7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BIRC7
      Search eBioscience for proteins for BIRC7
      Search eBioscience for elisas for BIRC7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BIRC7 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4