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BIRC6 Gene

protein-coding   GIFtS: 62
GCID: GC02P032582

Baculoviral IAP Repeat Containing 6

(Previous name: baculoviral IAP repeat-containing 6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Baculoviral IAP Repeat Containing 61 2     KIAA12893 5
Baculoviral IAP Repeat-Containing 61 2     apollon1
Ubiquitin-Conjugating BIR Domain Enzyme Apollon2 3     Baculoviral IAP Repeat-Containing Protein 62
APOLLON2 3     Ubiquitin-Conjugating BIR-Domain Enzyme Apollon2
BRUCE2 3     EC 6.3.2.-3
BIR Repeat-Containing Ubiquitin-Conjugating Enzyme2 3     

External Ids:    HGNC: 135161   Entrez Gene: 574482   Ensembl: ENSG000001157607   OMIM: 6056385   UniProtKB: Q9NR093   

Export aliases for BIRC6 gene to outside databases

Previous GC identifers: GC02P032525 GC02P032709 GC02P032556 GC02P032493 GC02P032435 GC02P032320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BIRC6 Gene:
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc
(ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the
degradation of apoptotic proteins by ubiquitination. (provided by RefSeq, Jul 2008)

GeneCards Summary for BIRC6 Gene:
BIRC6 (baculoviral IAP repeat containing 6) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is UBE2O.

UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09
Function: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3
ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single
polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin
ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important
regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission,
but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification

Gene Wiki entry for BIRC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BIRC6 gene promoter:
         E2F-3a   E2F-4   E2F-5   HTF   E2F-2   CREB   E2F-1   E2F   NRF-2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BIRC6 promoter sequence
   Search Chromatin IP Primers for BIRC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIRC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22.3

BIRC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P032582:  view genomic region     (about GC identifiers)

Start:
32,582,096 bp from pter      End:
32,843,966 bp from pter
Size:
261,871 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 6  
Size: 4857 amino acids; 530255 Da
Subunit: Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41,
DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1,
EXOC3/SEC6 and EXOC4/SEC8
Sequence caution: Sequence=BAA86603.2; Type=Frameshift; Positions=2047;
1 PDB 3D structure from and Proteopedia for BIRC6:
3CEG (3D)    
Secondary accessions: Q9ULD1

Explore the universe of human proteins at neXtProt for BIRC6: NX_Q9NR09

Explore proteomics data for BIRC6 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing
    inhibition of apoptosis. Deubiquitinated by USP8/UBPY1
  • Ubiquitination2 at Lys416, Lys1643, Lys2265, Lys2270, Lys2277, Lys2511, Lys3854, Lys4020
  • Modification sites at PhosphoSitePlus

  • See BIRC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057336.3  
    ENSEMBL proteins: 
     ENSP00000393596   ENSP00000413090   ENSP00000393590  

    BIRC6 Human Recombinant Protein Products:

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    antibodies-online proteins for BIRC6 (2 products) 

     
    antibodies-online peptides for BIRC6

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    antibodies-online antibodies for BIRC6 (43 products) 

    BIRC6 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2
    BIRC: Baculoviral IAP repeat containing

    5 InterPro protein domains:
     IPR022103 BIRC6
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR001370 BIR
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NR09

    ProtoNet protein and cluster: Q9NR09

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09
    Domain: The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and
    CASP9
    Similarity: In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family
    Similarity: Contains 1 BIR repeat


    Find genes that share domains with BIRC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC6_HUMAN, Q9NR09
    Function: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3
    ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single
    polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin
    ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important
    regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission,
    but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification
    Enzyme regulation: Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15200957
    GO:0004869cysteine-type endopeptidase inhibitor activity IMP15200957
    GO:0005515protein binding IPI14765125
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with BIRC6           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Birc6):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  normal 

    Find genes that share phenotypes with BIRC6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BIRC6: Birc6tm1Sjen Birc6tm1Nai

       genOway: Develop your customized and physiologically relevant rodent model for BIRC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIRC6:
    hsa-mir-615-3p (MIRT039908), hsa-mir-34a-5p (MIRT047374), hsa-let-7b-5p (MIRT004956), hsa-let-7a-5p (MIRT052603), hsa-mir-218-5p (MIRT005001)

    Block miRNA regulation of human, mouse, rat BIRC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BIRC6 (see all 60):
    hsa-miR-194* hsa-miR-3685 hsa-miR-140-5p hsa-miR-300 hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidBIRC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BIRC6
    Predesigned siRNA for gene silencing in human, mouse, rat BIRC6

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BIRC6_HUMAN, Q9NR09: Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton,
    spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Concentrates in a
    pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to
    the spindle midzone and the midbody in telophase and during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    cytosol3
    golgi apparatus3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA18329369
    GO:0005768endosome IDA18329369
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA18329369
    GO:0005815microtubule organizing center IDA18329369

    Find genes that share ontologies with BIRC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BIRC6 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    2Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35
    3Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    4Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with BIRC6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BIRC6
        Apoptosis Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for BIRC6
        Apoptosis and Autophagy

    1 BioSystems Pathway for BIRC6
        Apoptosis Modulation and Signaling


    1 Kegg Pathway  (Kegg details for BIRC6):
        Ubiquitin mediated proteolysis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC6: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BIRC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIRC6 (Q9NR091, 3 ENSP000003935964) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC4Q96A651, 3, ENSP000002538614EBI-1765160,EBI-355383 I2D: score=2 STRING: ENSP00000253861
    KIF23Q022411, 3, ENSP000002603634EBI-1765160,EBI-306852 I2D: score=2 STRING: ENSP00000260363
    PLK1P533501, 3, ENSP000003000934EBI-1765160,EBI-476768 I2D: score=2 STRING: ENSP00000300093
    MAP2K1Q027501, 3, ENSP000003024864EBI-1765160,EBI-492564 I2D: score=2 STRING: ENSP00000302486
    DIABLOQ9NR283, ENSP000002671694I2D: score=3 STRING: ENSP00000267169
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0006468protein phosphorylation TAS18329369
    GO:0006915apoptotic process IEA--
    GO:0007067mitosis IEA--
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with BIRC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIRC6

    4 HMDB Compounds for BIRC6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BIRC6 gene: 
    NM_016252.3  

    Unigene Cluster for BIRC6:

    Baculoviral IAP repeat containing 6
    Hs.150107  [show with all ESTs]
    Unigene Representative Sequence: NM_016252
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421745(uc010ezu.3) ENST00000466527 ENST00000444173 ENST00000431454
    ENST00000483194 ENST00000462504 ENST00000497023 ENST00000496555 ENST00000461788
    ENST00000471232 ENST00000470250 ENST00000465130
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BIRC6 (see all 60):
    hsa-miR-194* hsa-miR-3685 hsa-miR-140-5p hsa-miR-300 hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-519a
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      QuantiFast Probe-based Assays in human, mouse, rat BIRC6

    Additional mRNA sequence: 

    AB033115.2 AF265555.1 AK023788.1 AK023848.1 

    Selected DOTS entries (see all 31):

    DT.95336857  DT.215348  DT.100792969  DT.92447302  DT.100645661  DT.121002421  DT.205141  DT.432015 
    DT.91658480  DT.91664944  DT.91985441  DT.95308706  DT.121002393  DT.121002416  DT.121002484  DT.40306896 
    DT.91662884  DT.91972339  DT.92005199  DT.92447296  DT.95336825  DT.95336829  DT.95336831  DT.97819882 

    Selected AceView cDNA sequences (see all 331):

    AB033115 BU597382 AI082248 AI264018 AI913297 BG195880 BQ879186 BU186372 
    AI024885 AA664287 BG187116 AA243489 AI435871 AI360859 BU149541 BX509824 
    NM_016252 BG214651 BG342043 AI567393 BX643059 CB265267 BG200534 AA748188 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BIRC6 (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                                                    -                                                                                       

    ExUns: 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52a · 52b ^ 53 ^ 54 ^ 55a · 55b
    SP1:                                                                          -                                 
    SP2:                                                                          -           -                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for BIRC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BIRC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATTCTTC
    BIRC6 Expression
    About this image


    BIRC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    BIRC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIRC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150107

    UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09
    Tissue specificity: Expressed in brain cancer cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC6: 
              Apoptosis 384HT in human mouse rat
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BIRC6 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Birc61 , 5 baculoviral IAP repeat-containing 61, 5 89.26(n)1
    95.51(a)1
      17 (45.64 cM)5
    122111  NM_007566.31  NP_031592.31 
     745282955 
    chicken
    (Gallus gallus)
    Aves BIRC61 baculoviral IAP repeat containing 6 83.41(n)
    92.78(a)
      421463  XM_419512.4  XP_419512.4 
    lizard
    (Anolis carolinensis)
    Reptilia BIRC66
    baculoviral IAP repeat containing 6
    90(a)
    1 ↔ 1
    1(231870572-232074217)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.324942 Xenopus laevis transcribed sequences 77.24(n)    BJ618736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI473394.12   -- 75.44(n)    BI473394.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bruce1 , 3 anti-apoptosis ubiquitin conjugating
    enzyme3
    Bruce1
    51(a)3
    47.41(n)1
    40.28(a)1
      412601  NM_001275531.11  NP_001262460.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-173 ubiquitin-conjugating enzyme 52(a)   X(7088508-7090629)   --
    wheat
    (Triticum aestivum)
    Liliopsida Ta.90702 Triticum aestivum transcribed sequence with weak similarity more 72.2(n)    CD922764.1 


    ENSEMBL Gene Tree for BIRC6 (if available)
    TreeFam Gene Tree for BIRC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BIRC6 gene
    UBE2O2  UBE2Z2  
    5 SIMAP similar genes for BIRC6 using alignment to 3 protein entries:     BIRC6_HUMAN (see all proteins):
    ILP3    UBE2N    HR6A    UBE2Z    UBE2A

    Find genes that share paralogs with BIRC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BIRC6 (see all 5261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158243231,2
    F--32580210(+) TAAAAA/CTGTGT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1836024351,2
    --32580270(+) TTGACC/TGGAAT 1 -- us2k10--------
    rs1884897541,2
    --32580290(+) TCAAAC/TATGAC 1 -- us2k10--------
    rs1466997481,2
    --32580338(+) CCAATA/GAAGTC 1 -- us2k10--------
    rs1924801051,2
    --32580472(+) TCAGGA/CGTTCA 1 -- us2k10--------
    rs130035901,2
    C--32580523(+) aaaatC/Acaaaa 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1848446291,2
    --32580600(+) TGAGGA/CCGAGA 1 -- us2k10--------
    rs1877895781,2
    C--32580689(+) ACTCCA/GTCTCA 1 -- us2k10--------
    rs1510745821,2
    C--32580721(+) AAAAA-/GCCAAAAA 1 -- us2k10--------
    rs101733051,2
    C,H--32580850(+) tttcaG/Aatgta 1 -- us2k14Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for BIRC6 (32582096 - 32832096 bp, first 250kb of BIRC6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BIRC6 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719881CNV Deletion23290073
    esv2464710CNV Deletion19546169
    esv2664912CNV Deletion23128226
    esv2422472CNV Duplication17116639
    esv2422335CNV Duplication17116639
    nsv873782CNV Loss21882294
    nsv833692CNV Loss17160897
    nsv873781CNV Loss21882294
    nsv873780CNV Loss21882294
    nsv470447CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIRC6
    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605638    OMIM disorders: --


    Find genes that share disorders with BIRC6           About GenesLikeMe

    Genetic Association Database (GAD): BIRC6
    Human Genome Epidemiology (HuGE) Navigator: BIRC6 (2 documents)

    Export disorders for BIRC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BIRC6 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with BIRC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human IAP-family gene, apollon, expressed in human brain cancer cells. (PubMed id 10544019)1, 2, 3, 9 Chen Z.... Tsuruo T. (Biochem. Biophys. Res. Commun. 1999)
    2. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PubMed id 14765125)1, 2, 9 Qiu X.B.... Goldberg A.L. (EMBO J. 2004)
    3. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PubMed id 15200957)1, 2, 9 Bartke T.... Jentsch S. (Mol. Cell 2004)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)1, 2 Pohl C. and Jentsch S. (Cell 2008)
    7. IAPs: more than just inhibitors of apoptosis proteins. (PubMed id 18414036)1, 2 Dubrez-Daloz L.... Cartier J. (Cell Cycle 2008)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    10. HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells. (PubMed id 15781261)1, 9 Sekine K....Naito M. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57448 HGNC: 13516 AceView: BIRC6 Ensembl:ENSG00000115760 euGenes: HUgn57448
    ECgene: BIRC6 Kegg: 57448 H-InvDB: BIRC6

    (According to HUGE)
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    HUGE: KIAA1289

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BIRC6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BIRC6 gene:
    Search GeneIP for patents involving BIRC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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