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Aliases for BIRC6 Gene

Aliases for BIRC6 Gene

  • Baculoviral IAP Repeat Containing 6 2 3 5
  • Apollon 2 3 4
  • BIR Repeat-Containing Ubiquitin-Conjugating Enzyme 3 4
  • Ubiquitin-Conjugating BIR Domain Enzyme Apollon 3 4
  • BRUCE 3 4
  • Ubiquitin-Conjugating BIR-Domain Enzyme Apollon 3
  • Baculoviral IAP Repeat-Containing Protein 6 3
  • Baculoviral IAP Repeat-Containing 6 2
  • EC 6.3.2.- 4
  • KIAA1289 4

External Ids for BIRC6 Gene

Previous GeneCards Identifiers for BIRC6 Gene

  • GC02P032525
  • GC02P032709
  • GC02P032556
  • GC02P032493
  • GC02P032435
  • GC02P032582
  • GC02P032320

Summaries for BIRC6 Gene

Entrez Gene Summary for BIRC6 Gene

  • This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for BIRC6 Gene

BIRC6 (Baculoviral IAP Repeat Containing 6) is a Protein Coding gene. Diseases associated with BIRC6 include Brain Cancer. Among its related pathways are Apoptosis - multiple species and Apoptosis and Autophagy. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2O.

UniProtKB/Swiss-Prot for BIRC6 Gene

  • Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Gene Wiki entry for BIRC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC6 Gene

Genomics for BIRC6 Gene

Regulatory Elements for BIRC6 Gene

Enhancers for BIRC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BIRC6 on UCSC Golden Path with GeneCards custom track

Promoters for BIRC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BIRC6 Gene

Chromosome:
2
Start:
32,357,028 bp from pter
End:
32,618,899 bp from pter
Size:
261,872 bases
Orientation:
Plus strand

Genomic View for BIRC6 Gene

Genes around BIRC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC6 Gene

Proteins for BIRC6 Gene

  • Protein details for BIRC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR09-BIRC6_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 6
    Protein Accession:
    Q9NR09
    Secondary Accessions:
    • Q9ULD1

    Protein attributes for BIRC6 Gene

    Size:
    4857 amino acids
    Molecular mass:
    530255 Da
    Quaternary structure:
    • Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.
    SequenceCaution:
    • Sequence=BAA86603.2; Type=Frameshift; Positions=2047; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BIRC6 Gene

neXtProt entry for BIRC6 Gene

Post-translational modifications for BIRC6 Gene

  • Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.
  • Ubiquitination at Lys 416, Lys 1643, Lys 2265, Lys 2270, Lys 2277, Lys 2511, Lys 3854, and Lys 4020
  • Modification sites at PhosphoSitePlus

Other Protein References for BIRC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BIRC6 (BIRC6)
  • Cloud-Clone Corp. Antibodies for BIRC6

No data available for DME Specific Peptides for BIRC6 Gene

Domains & Families for BIRC6 Gene

Suggested Antigen Peptide Sequences for BIRC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR09

UniProtKB/Swiss-Prot:

BIRC6_HUMAN :
  • The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.
  • In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
  • Contains 1 BIR repeat.
Domain:
  • The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.
Family:
  • In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Similarity:
  • Contains 1 BIR repeat.
genes like me logo Genes that share domains with BIRC6: view

Function for BIRC6 Gene

Molecular function for BIRC6 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.
UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Enzyme Numbers (IUBMB) for BIRC6 Gene

Gene Ontology (GO) - Molecular Function for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 15200957
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 15200957
GO:0005515 protein binding IEA,IPI 14765125
GO:0016874 ligase activity IEA --
GO:0061631 ubiquitin conjugating enzyme activity IEA --
genes like me logo Genes that share ontologies with BIRC6: view
genes like me logo Genes that share phenotypes with BIRC6: view

Animal Models for BIRC6 Gene

MGI Knock Outs for BIRC6:

Animal Model Products

  • Taconic Biosciences Mouse Models for BIRC6

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC6 Gene

Localization for BIRC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC6 Gene

Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC6 Gene COMPARTMENTS Subcellular localization image for BIRC6 gene
Compartment Confidence
cytoskeleton 5
endosome 5
golgi apparatus 5
cytosol 4
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 18329369
GO:0005768 endosome IDA 18329369
GO:0005802 trans-Golgi network IDA 18329369
GO:0005815 microtubule organizing center IDA 18329369
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with BIRC6: view

Pathways & Interactions for BIRC6 Gene

genes like me logo Genes that share pathways with BIRC6: view

Pathways by source for BIRC6 Gene

1 Cell Signaling Technology pathway for BIRC6 Gene
1 BioSystems pathway for BIRC6 Gene
1 R&D Systems pathway for BIRC6 Gene

SIGNOR curated interactions for BIRC6 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEA --
GO:0006468 protein phosphorylation TAS 18329369
GO:0006915 apoptotic process IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with BIRC6: view

Drugs & Compounds for BIRC6 Gene

(7) Drugs for BIRC6 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
AEG40826 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
GDC0917 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0

(1) Additional Compounds for BIRC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with BIRC6: view

Transcripts for BIRC6 Gene

Unigene Clusters for BIRC6 Gene

Baculoviral IAP repeat containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52a · 52b ^ 53 ^ 54 ^ 55a · 55b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for BIRC6 Gene

GeneLoc Exon Structure for
BIRC6
ECgene alternative splicing isoforms for
BIRC6

Expression for BIRC6 Gene

mRNA expression in normal human tissues for BIRC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BIRC6 Gene

This gene is overexpressed in Heart (17.5), Bone (16.3), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BIRC6 Gene



Protein tissue co-expression partners for BIRC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BIRC6 Gene:

BIRC6

SOURCE GeneReport for Unigene cluster for BIRC6 Gene:

Hs.150107

mRNA Expression by UniProt/SwissProt for BIRC6 Gene:

Q9NR09-BIRC6_HUMAN
Tissue specificity: Expressed in brain cancer cells.
genes like me logo Genes that share expression patterns with BIRC6: view

Primer Products

No data available for mRNA differential expression in normal tissues for BIRC6 Gene

Orthologs for BIRC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BIRC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BIRC6 34
  • 93.53 (n)
  • 97.74 (a)
BIRC6 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC6 34
  • 93.74 (n)
  • 97.76 (a)
BIRC6 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc6 34
  • 89.26 (n)
  • 95.51 (a)
Birc6 16
Birc6 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIRC6 34
  • 99.65 (n)
  • 99.77 (a)
BIRC6 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Birc6 34
  • 89.7 (n)
  • 96.01 (a)
oppossum
(Monodelphis domestica)
Mammalia BIRC6 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC6 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves BIRC6 34
  • 83.41 (n)
  • 92.78 (a)
BIRC6 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIRC6 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia birc6 34
  • 76.9 (n)
  • 87.04 (a)
Str.10024 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32494 34
zebrafish
(Danio rerio)
Actinopterygii birc6 34
  • 71.06 (n)
  • 82.45 (a)
birc6 35
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bruce 36
  • 51 (a)
Bruce 34
  • 47.41 (n)
  • 40.28 (a)
Bruce 35
  • 32 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002651 34
  • 46.13 (n)
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-17 36
  • 52 (a)
ubc-17 35
  • 33 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.9070 34
Species where no ortholog for BIRC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BIRC6 Gene

ENSEMBL:
Gene Tree for BIRC6 (if available)
TreeFam:
Gene Tree for BIRC6 (if available)

Paralogs for BIRC6 Gene

Paralogs for BIRC6 Gene

(5) SIMAP similar genes for BIRC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BIRC6: view

Variants for BIRC6 Gene

Sequence variations from dbSNP and Humsavar for BIRC6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1033750 -- 32,439,197(+) tgtgt(A/G)tgtgt intron-variant
rs1033751 -- 32,470,691(+) AGAGT(C/T)AGATG intron-variant
rs1043463 -- 32,618,228(+) ATTTT(A/T)TTTTT nc-transcript-variant, utr-variant-3-prime
rs1065038 -- 32,549,391(+) GGCAG(A/T)ACAGT nc-transcript-variant, reference, missense
rs1065039 -- 32,549,394(+) AGAAC(A/T)GTAAT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BIRC6 Gene

Variant ID Type Subtype PubMed ID
dgv1109e212 CNV gain 25503493
dgv3749n100 CNV gain 25217958
dgv3750n100 CNV gain 25217958
dgv443n27 CNV gain 19166990
dgv6750n54 CNV gain 21841781
esv2422335 CNV duplication 17116639
esv2422472 CNV duplication 17116639
esv2464710 CNV deletion 19546169
esv2664912 CNV deletion 23128226
esv2719881 CNV deletion 23290073
esv2751888 CNV gain 17911159
esv2763243 CNV gain 21179565
esv3590247 CNV loss 21293372
esv3590248 CNV gain 21293372
esv3590249 CNV gain 21293372
esv3590250 CNV gain 21293372
esv3590251 CNV gain 21293372
esv3590252 CNV gain 21293372
esv3590254 CNV gain 21293372
esv3590256 CNV gain 21293372
esv3891703 CNV gain 25118596
nsv1005939 CNV gain 25217958
nsv1109243 CNV deletion 24896259
nsv1138763 CNV deletion 24896259
nsv456108 CNV gain 19166990
nsv470447 CNV loss 18288195
nsv470448 CNV gain 18288195
nsv478791 CNV novel sequence insertion 20440878
nsv516173 CNV gain+loss 19592680
nsv581274 CNV gain 21841781
nsv581281 CNV gain 21841781
nsv833681 CNV gain+loss 17160897
nsv833692 CNV loss 17160897
nsv833703 CNV loss 17160897

Variation tolerance for BIRC6 Gene

Residual Variation Intolerance Score: 0.0602% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BIRC6 Gene

Human Gene Mutation Database (HGMD)
BIRC6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIRC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC6 Gene

Disorders for BIRC6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BIRC6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
Search BIRC6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BIRC6

Genetic Association Database (GAD)
BIRC6
Human Genome Epidemiology (HuGE) Navigator
BIRC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIRC6
genes like me logo Genes that share disorders with BIRC6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC6 Gene

Publications for BIRC6 Gene

  1. A human IAP-family gene, apollon, expressed in human brain cancer cells. (PMID: 10544019) Chen Z. … Tsuruo T. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 65
  2. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PMID: 14765125) Qiu X.B. … Goldberg A.L. (EMBO J. 2004) 3 4 22 65
  3. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PMID: 15200957) Bartke T. … Jentsch S. (Mol. Cell 2004) 3 4 22 65
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 65
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 65

Products for BIRC6 Gene

Sources for BIRC6 Gene

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