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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BIRC6 Gene

protein-coding GIFtS: 61
GCID: GC02P032582

baculoviral IAP repeat containing 6

(Previous name: baculoviral IAP repeat-containing 6 )

Explore 9 diseases affiliated with
BIRC6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Baculoviral IAP Repeat Containing 6¹ ²		BIR Repeat-Containing Ubiquitin-Conjugating Enzyme² ³
BRUCE¹ ² ³		KIAA1289³ ⁵
Baculoviral IAP Repeat-Containing 6¹ ²		Baculoviral IAP Repeat-Containing Protein 6²
Ubiquitin-Conjugating BIR Domain Enzyme Apollon² ³		Ubiquitin-Conjugating BIR-Domain Enzyme Apollon²
APOLLON² ³		EC 6.3.2.-³

External Ids:	HGNC: 13516¹	Entrez Gene: 57448²	Ensembl: ENSG00000115760⁷	OMIM: 605638⁵	UniProtKB: Q9NR09³

Export aliases for BIRC6 gene to outside databases

Previous GC identifers: GC02P032525 GC02P032709 GC02P032556 GC02P032493 GC02P032435 GC02P032320

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BIRC6:

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc

(ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation

of apoptotic proteins by ubiquitination. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09

Function: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3

ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single

polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin

ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator

for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the

integrity of the midbody and the midbody ring, and its striking ubiquitin modification

Gene Wiki entry for BIRC6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BIRC6 gene promoter:
E2F-3a E2F-4 E2F-5 HTF E2F-2 CREB E2F-1 E2F NRF-2 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BIRC6 promoter sequence

Search SABiosciences Chromatin IP Primers for BIRC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3 Ensembl cytogenetic band: 2p22.3 HGNC cytogenetic band: 2p22.3

BIRC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC6 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P032582: view genomic region (about GC identifiers)

Start:	32,582,096 bp from pter	End:	32,843,966 bp from pter
Size:	261,871 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 6

Size: 4857 amino acids; 530255 Da

Subunit: Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41,

DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6

and EXOC4/SEC8

Subcellular location: Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton,

spindle pole. Cytoplasm, cytoskeleton, centrosome. Note=Concentrates in a pericentriolar compartment in interphase,

moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in

telophase and during cytokinesis

Sequence caution: Sequence=BAA86603.2; Type=Frameshift; Positions=2047;

1 PDB 3D structure from and Proteopedia for BIRC6:

3CEG (3D)

Secondary accessions: Q9ULD1

Explore the universe of human proteins at neXtProt for BIRC6: NX_Q9NR09

Post-translational modifications:

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing

inhibition of apoptosis. Deubiquitinated by USP8/UBPY¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NR09

BIRC6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057336.3

ENSEMBL proteins:

ENSP00000393596 ENSP00000413090 ENSP00000393590

Human Recombinant Protein Products:

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	Uscn Proteins for BIRC6

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	18329369
GO:0005575	cellular_component	ND	--
GO:0005624	membrane fraction	--	--
GO:0005768	endosome	IDA	18329369
GO:0005794	Golgi apparatus	IEA	--

BIRC6 for ontologies About GeneDecksing

BIRC6 Antibody Products:

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	ThermoFisher Antibodies for BIRC6

Assay Products for BIRC6:

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	GenScript Custom Assay Services for BIRC6
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	Uscn ELISAs and CLIAs for BIRC6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BIRC6 for domains About GeneDecksing

5 InterPro domains/families:

IPR016135 UBQ-conjugating_enzyme/RWD

IPR022103 DUF3643

IPR001370 BIR

IPR015943 WD40/YVTN_repeat-like_dom

IPR000608 UBQ-conjugat_E2

Graphical View of Domain Structure for InterPro Entry Q9NR09

ProtoNet protein and cluster: Q9NR09

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09

Domain: The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and

CASP9

Similarity: In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family

Similarity: Contains 1 BIR repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09

Function: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3

ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single

polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin

ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator

for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the

integrity of the midbody and the midbody ring, and its striking ubiquitin modification

Enzyme regulation: Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9

Enzyme Number (IUBMB): EC 6.3.2.-¹

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		hsa-miR-194* hsa-miR-3685 hsa-miR-140-5p hsa-miR-300 hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: BIRC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: BIRC6 (NM_016252)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC6

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	15200957
GO:0004869	cysteine-type endopeptidase inhibitor activity	IMP	15200957
GO:0005515	protein binding	IPI	18329369

BIRC6 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for BIRC6: Birc6^tm1Sjen Birc6^tm1Nai
     12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Birc6):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging
nervous system	normal

BIRC6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Antigen processing: Ubiquitination & Proteasome degradation

Ubiquitin mediated proteolysis

0.36

Apoptosis and survival_Apoptotic TNF-family pathways

Apoptosis Signaling Pathways

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for BIRC6

Apoptosis Signaling Pathways

1 Cell Signaling Technology (CST) Pathway for BIRC6

Apoptosis and Autophagy

1 BioSystems Pathway for BIRC6

Apoptosis Modulation and Signaling

1 Kegg Pathway (Kegg details for BIRC6):

Ubiquitin mediated proteolysis

BIRC6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BIRC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/26 Interacting proteins for BIRC6 (Q9NR09^{1, 3} ENSP00000393596⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOC4	Q96A65¹^,³, ENSP00000253861⁴	EBI-1765160,EBI-1058596 I2D: score=2 STRING: ENSP00000253861
KIF23	Q02241¹^,³, ENSP00000260363⁴	EBI-1765160,EBI-2558308 I2D: score=2 STRING: ENSP00000260363
MAP2K1	Q02750¹^,³, ENSP00000302486⁴	EBI-1765160,EBI-492564 I2D: score=2 STRING: ENSP00000302486
PLK1	P53350¹^,³, ENSP00000300093⁴	EBI-1765160,EBI-476768 I2D: score=2 STRING: ENSP00000300093
DIABLO	Q9NR28³, ENSP00000267169⁴	I2D: score=3 STRING: ENSP00000267169

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001890	placenta development	--	--
GO:0006468	protein phosphorylation	TAS	18329369
GO:0006915	apoptotic process	IEA	--
GO:0007067	mitosis	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--

BIRC6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BIRC6

4 HMDB Compounds for BIRC6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about BIRC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BIRC6 gene:

NM_016252.3

Unigene Cluster for BIRC6:

Baculoviral IAP repeat containing 6

Hs.150107 [show with all ESTs]

Unigene Representative Sequence: NM_016252

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000421745(uc010ezu.3) ENST00000466527 ENST00000444173 ENST00000431454

ENST00000483194 ENST00000462504 ENST00000497023 ENST00000496555 ENST00000461788

ENST00000471232 ENST00000470250 ENST00000465130

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIRC6
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate BIRC6 (see all 60):
		hsa-miR-194* hsa-miR-3685 hsa-miR-140-5p hsa-miR-300 hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: BIRC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: BIRC6 (NM_016252)
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Additional cDNA sequence:

AB033115.2 AF265555.1 AK023788.1 AK023848.1

24/31 DOTS entries (see all 31):

DT.95336857 DT.215348 DT.100792969 DT.92447302 DT.100645661 DT.121002421 DT.205141 DT.432015

DT.91658480 DT.91664944 DT.91985441 DT.95308706 DT.121002393 DT.121002416 DT.121002484 DT.40306896

DT.91662884 DT.91972339 DT.92005199 DT.92447296 DT.95336825 DT.95336829 DT.95336831 DT.97819882

24/331 AceView cDNA sequences (see all 331):

AA479961 CB321907 BX411218 AI024885 BM479646 AI033330 AI360859 BG187116

BG191304 BM674459 NM_016252 AI874046 CB265267 AI066593 AW073504 BX642916

BG342043 AA315620 AB033115 BU149541 AA748188 BU520793 AL119669 BU193719

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC6 (see all 19) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:
SP2:
SP3:
SP4:											-
SP5:																							-

ExUns:	24	^	25	^	26a	·	26b	·	26c	^	27	^	28	^	29a	·	29b	^	30a	·	30b	·	30c	^	31	^	32a	·	32b	·	32c	^	33	^	34a	·	34b	^	35a	·	35b	·	35c	^	36	^	37	^	38	^	39	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47	^	48	^	49	^	50	^	51	^	52a	·	52b	^	53	^	54	^	55a	·	55b
SP1:																									-
SP2:																									-				-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BIRC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BIRC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATTCTTC

About this image

BIRC6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Gut Tube

Ventral Foregut Endoderm

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BIRC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BIRC6

SOURCE GeneReport for Unigene cluster: Hs.150107

UniProtKB/Swiss-Prot: BIRC6_HUMAN, Q9NR09

Tissue specificity: Expressed in brain cancer cells

SABiosciences Expression via Pathway-Focused PCR Arrays including BIRC6:

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for BIRC6 gene from 6/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BIRC6¹	baculoviral IAP repeat containing 6	83.56(n) 92.86(a)		421463 XM_419512.3 XP_419512.3
lizard (Anolis carolinensis)	Reptilia	--	--	73(a)	1 ↔ 1	1(231883729-231888402)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32494²	Xenopus laevis transcribed sequences	77.24(n)		BJ618736.1
zebrafish (Danio rerio)	Actinopterygii	BI473394.1²	--	75.44(n)		BI473394.1
fruit fly (Drosophila melanogaster)	Insecta	Bruce^{1 , 3}	anti-apoptosis ubiquitin conjugating enzyme³ Bruce-PA¹	51(a)³ 46.14(n)¹ 37.93(a)¹		41260¹ NM_141738.3¹ NP_649995.2¹
wheat (Triticum aestivum)	Liliopsida	Ta.9070²	Triticum aestivum transcribed sequence with weak similarity more	72.2(n)		CD922764.1

ENSEMBL Gene Tree for BIRC6 (if available)
TreeFam Gene Tree for BIRC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BIRC6 gene

UBE2B² UBE2S² UBE2O² UBE2Z² UBE2A²

6 SIMAP similar genes for BIRC6 using alignment to 3 protein entries: BIRC6_HUMAN (see all proteins):

ILP3 UBE2N HR6A UBE2Z UBE2A UBE2B

BIRC6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115824323^1,2	F,	--	32580210(+)	`TAAAAA/CTGTGT`	1	--	us2k¹		1		WA	118
rs183602435^1,2		--	32580270(+)	`TTGACC/TGGAAT`	1	--	us2k¹		0	--	--	--	--
rs188489754^1,2		--	32580290(+)	`TCAAAC/TATGAC`	1	--	us2k¹		0	--	--	--	--
rs146699748^1,2		--	32580338(+)	`CCAATA/GAAGTC`	1	--	us2k¹		0	--	--	--	--
rs192480105^1,2		--	32580472(+)	`TCAGGA/CGTTCA`	1	--	us2k¹		0	--	--	--	--
rs13003590^1,2	C	--	32580523(+)	`aaaatC/Acaaaa`	1	--	us2k¹		1		NA	2
rs184844629^1,2		--	32580600(+)	`TGAGGA/CCGAGA`	1	--	us2k¹		0	--	--	--	--
rs187789578^1,2		--	32580689(+)	`ACTCCA/GTCTCA`	1	--	us2k¹		0	--	--	--	--
rs151074582^1,2		--	32580721(+)	`AAAAA-/GCCAAAAA`	1	--	us2k¹		0	--	--	--	--
rs10173305^1,2	C,H	--	32580850(+)	`TTTCAG/AATGTA`	1	--	us2k¹		4		NS EA	418

HapMap Linkage Disequilibrium report for BIRC6 (32582096 - 32832096 bp, first 250kb of BIRC6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for BIRC6
6 CNVs: 53694 97804 5202 50461 8367 5203

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC6

DNA2.0 Custom Variant and Variant Library Synthesis for BIRC6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BIRC6 for disorders           About GeneDecksing

OMIM gene information: 605638    OMIM disorders: --

9 diseases for BIRC6:    About MalaCards

dilated cardiomyopathy gigantism cardiomyopathy brain cancer

breast cancer hypoxia neuronitis pancreatic cancer

pancreatitis

Human Genome Epidemiology (HuGE) Navigator: BIRC6 (2 documents)

Export disorders for BIRC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BIRC6 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with BIRC6)

Utopia: connect your pdf to the dynamic
world of online information

A human IAP-family gene, apollon, expressed in human brain cancer cells. (PubMed id 10544019)^{1, 2, 3, 9} Chen Z.... Tsuruo T. (1999)
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PubMed id 14765125)^{1, 2, 9} Qiu X.B....Goldberg A.L. (2004)
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PubMed id 15200957)^{1, 2, 9} Bartke T....Jentsch S. (2004)
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)^{1, 2} Pohl C. and Jentsch S. (2008)
IAPs: more than just inhibitors of apoptosis proteins . (PubMed id 18414036)^{1, 2} Dubrez-Daloz L....Cartier J. (2008)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells. (PubMed id 15781261)^{1, 9} Sekine K....Naito M. (2005)
The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. (PubMed id 15507451)^{1, 9} Qiu X.B. and Goldberg A.L. (2005)
Role of Apollon in human melanoma resistance to antitu mor agents that activate the intrinsic or the extrinsic apoptosis pathways. (PubMed id 22553342)¹ Tassi E....Anichini A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57448	HGNC: 13516	AceView: BIRC6	Ensembl:ENSG00000115760	euGenes: HUgn57448
ECgene: BIRC6	Kegg: 57448	H-InvDB: BIRC6

(According to HUGE)
About This Section

HUGE: KIAA1289

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BIRC6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BIRC6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BIRC6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BIRC6 gene:
Search GeneIP for patents involving BIRC6

GeneCards and IP:
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BIRC6 Gene

baculoviral IAP repeat containing 6

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BIRC6 Gene

baculoviral IAP repeat containing 6

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