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BIRC5 Gene

protein-coding   GIFtS: 67
GCID: GC17P076210

Baculoviral IAP Repeat Containing 5

(Previous names: apoptosis inhibitor 4, baculoviral IAP repeat-containing...)
(Previous symbol: API4)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Baculoviral IAP Repeat Containing 51 2     Baculoviral IAP Repeat-Containing 51
API41 2 3 5     EPR-12
Apoptosis Inhibitor 41 2 3     Baculoviral IAP Repeat-Containing Protein 52
Survivin Variant 3 Alpha1 2     IAP43
Apoptosis Inhibitor Survivin2 3     

External Ids:    HGNC: 5931   Entrez Gene: 3322   Ensembl: ENSG000000896857   OMIM: 6033525   UniProtKB: O153923   

Export aliases for BIRC5 gene to outside databases

Previous GC identifers: GC17M076124 GC17P079197 GC17P076671 GC17P076808 GC17P076809 GC17P073722 GC17P071634


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BIRC5 Gene:
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins
that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR)
domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a
C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in
adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this
gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for BIRC5 Gene:
BIRC5 (baculoviral IAP repeat containing 5) is a protein-coding gene. Diseases associated with BIRC5 include laryngeal squamous cell carcinoma, and cervical carcinosarcoma. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392
Function: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis.
Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and
segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex;
directs CPC movement to different locations from the inner centromere during prometaphase to midbody during
cytokinesis and participates in the organization of the center spindle by associating with polymerized
microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to
help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in
G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in
neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis.
Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type
isoform

Gene Wiki entry for BIRC5 (Survivin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BIRC5 gene promoter:
         Sp1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBIRC5 promoter sequence
   Search Chromatin IP Primers for BIRC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIRC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

BIRC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P076210:  view genomic region     (about GC identifiers)

Start:
76,210,267 bp from pter      End:
76,221,717 bp from pter
Size:
11,451 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 5  
Size: 142 amino acids; 16389 Da
Subunit: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The
monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of
enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex
binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger
complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB.
Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both
the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1.
The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with
XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with
DIABLO/SMAC. Interacts with BIRC6/bruce
Developmental stage: Expression is cell cycle-dependent and peaks at mitosis
Selected PDB 3D structures from and Proteopedia for BIRC5 (see all 21):
1E31 (3D)        1F3H (3D)        1XOX (3D)        2QFA (3D)        2RAW (3D)        2RAX (3D)    
Secondary accessions: A2SUH6 B2R4R1 Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8
Alternative splicing: 7 isoforms:  O15392-1   O15392-2   O15392-3   O15392-4   O15392-5   O15392-6   O15392-7   

Explore the universe of human proteins at neXtProt for BIRC5: NX_O15392

Explore proteomics data for BIRC5 at MOPED

Post-translational modifications: 

  • Ubiquitination is required for centrosomal targeting1
  • In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic
    chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities1
  • Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of
    monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses
    STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines
    its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3
    transactivation1
  • Ubiquitination2 at Lys23
  • Modification sites at PhosphoSitePlus

  • See BIRC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001012270.1  NP_001012271.1  NP_001159.2  

    ENSEMBL proteins: 
     ENSP00000301633   ENSP00000324180   ENSP00000467336   ENSP00000364086   ENSP00000465868  
     ENSP00000466617   ENSP00000466063   ENSP00000466675   ENSP00000467259  
    Reactome Protein details: O15392

    BIRC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BIRC5 (Survivin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BIRC5
    OriGene Protein Over-expression Lysate for BIRC5
    OriGene MassSpec for BIRC5
    OriGene Custom Protein Services for BIRC5
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    Novus Biologicals BIRC5 Proteins
    Novus Biologicals BIRC5 Lysates
    Sino Biological Recombinant Protein for BIRC5
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BIRC5
    Browse Proteins at Cloud-Clone Corp.

    BIRC5 Antibody Products:

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    OriGene Antibodies for BIRC5
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    Novus Biologicals BIRC5 Antibodies
    Abcam antibodies for BIRC5
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    BIRC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for BIRC5 (survivin)
    Enzo Life Sciences assays for BIRC5
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BIRC: Baculoviral IAP repeat containing

    1 InterPro protein domain:
     IPR001370 BIR

    Graphical View of Domain Structure for InterPro Entry O15392

    ProtoNet protein and cluster: O15392

    UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392
    Domain: The BIR repeat is necessary and sufficient for LAMTOR5 binding
    Similarity: Belongs to the IAP family
    Similarity: Contains 1 BIR repeat


    BIRC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC5_HUMAN, O15392
    Function: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis.
    Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and
    segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex;
    directs CPC movement to different locations from the inner centromere during prometaphase to midbody during
    cytokinesis and participates in the organization of the center spindle by associating with polymerized
    microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to
    help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in
    G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in
    neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis.
    Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type
    isoform
    Induction: Up-regulated by COMP

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004869cysteine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding IPI11069302
    GO:0008017microtubule binding TAS--
    GO:0008270zinc ion binding NAS10949039
    GO:0008536Ran GTPase binding IPI18591255
         
    BIRC5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BIRC5:
     Decreased viability of wild-ty  Increased cell death HMECs cel  Increased cell number in G2M,  

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Birc5):
     cellular  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  normal 

    BIRC5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Birc5tm1Emc for BIRC5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIRC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIRC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIRC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIRC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIRC5:
    hsa-mir-149-5p (MIRT045690), hsa-mir-10a-5p (MIRT025591), hsa-mir-1226-3p (MIRT036530), hsa-mir-484 (MIRT041728), hsa-mir-1301-3p (MIRT036054), hsa-mir-425-5p (MIRT016656), hsa-mir-335-5p (MIRT007304), hsa-mir-101-3p (MIRT027310), hsa-mir-542-3p (MIRT005363), hsa-let-7b-5p (MIRT052024), hsa-mir-30c-5p (MIRT047940), hsa-mir-93-5p (MIRT048806), hsa-mir-203a (MIRT006256)

    Block miRNA regulation of human, mouse, rat BIRC5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate BIRC5:
    hsa-miR-203 hsa-miR-548p hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmidBIRC5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BIRC5

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): BIRC5 (NM_001168)
    Sino Biological Human cDNA Clone for BIRC5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BIRC5_HUMAN, O15392: Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.
    Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from
    prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in
    anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes.
    Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby
    inhibiting XPO1/CRM1-mediated nuclear export
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus5
    mitochondrion3
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome IDA16322459
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0000777condensed chromosome kinetochore IDA15665297
    GO:0005634nucleus IDA15665297
    GO:0005737cytoplasm IDA--

    BIRC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BIRC5 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin-TIE2 Signaling0.36
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    5Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BIRC5
        Apoptosis Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BIRC5
        Colorectal Cancer Metastasis
    Angiopoietin-TIE2 Signaling
    WNT Signaling
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for BIRC5
        Apoptosis and Autophagy

    3 GeneGo (Thomson Reuters) Pathways for BIRC5
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Development Thrombopoietin-regulated cell processes
    Development Angiopoietin - Tie2 signaling

    Selected BioSystems Pathways for BIRC5 (see all 8)
        Apoptosis
    Apoptosis Modulation and Signaling
    IL-3 Signaling Pathway
    Interleukin-11 Signaling Pathway
    Aurora A signaling

    1 Sino Biological Pathway for BIRC5
        Death Receptor Signaling

    3 Reactome Pathways for BIRC5
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


    4 Kegg Pathways  (Kegg details for BIRC5):
        Hippo signaling pathway
    Hepatitis B
    Pathways in cancer
    Colorectal cancer


    BIRC5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC5 (see all 10): 
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Cancer Drug Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BIRC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIRC5 (O153921, 2, 3 ENSP000003016334) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKBQ96GD41, 2, 3, ENSP000003139504EBI-518823,EBI-624291 MINT-4509558 MINT-4509592 MINT-4509580 I2D: score=5 STRING: ENSP00000313950
    INCENPQ9NQS71, 2, 3, ENSP000003782954EBI-518823,EBI-307907 MINT-4509563 MINT-4509570 MINT-77929 I2D: score=4 STRING: ENSP00000378295
    CDCA8Q53HL21, 2, 3, ENSP000003161214EBI-518823,EBI-979174 MINT-4509524 MINT-4509575 I2D: score=4 STRING: ENSP00000316121
    XPO1O149801, 2, 3EBI-518823,EBI-355867 MINT-4055407 MINT-4509587 I2D: score=3 
    CDK1P064931, 3EBI-518823,EBI-444308 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA9859993
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis IMP12805209
    GO:0006351transcription, DNA-templated IEA--

    BIRC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for BIRC5
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIRC5

    Selected Novoseek inferred chemical compound relationships for BIRC5 gene (see all 160)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naphtho(1,2-b)furan-4,5-dione 73.5 3 20197088 (1), 19747539 (1), 20036260 (1)
    ciap2 71.7 11 17255535 (2), 15380346 (2), 17208224 (2), 19269012 (2) (see all 6)
    paclitaxel 64 152 14722122 (10), 19228734 (7), 15574781 (7), 15754318 (7) (see all 42)
    suberoylanilide hydroxamic acid 63.6 17 20028765 (4), 18156316 (3), 17654699 (1), 19553104 (1) (see all 6)
    deguelin 63.3 21 18089792 (5), 18593368 (4), 19781773 (3), 17035597 (2) (see all 5)
    ponicidin 62.8 5 19330074 (2), 16537182 (2), 17049940 (1)
    purvalanol a 62.5 2 17011457 (1), 14988404 (1)
    noxa 59.6 9 18712736 (1), 14508115 (1), 17569614 (1), 17038534 (1) (see all 9)
    flavopiridol 59.6 13 12517802 (2), 16820931 (2), 20206141 (1), 12517783 (1) (see all 9)
    tetra-o-methylnordihydroguaiaretic acid 58.5 3 17454637 (2), 16890802 (1)



    BIRC5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BIRC5 gene (3 alternative transcripts): 
    NM_001012270.1  NM_001012271.1  NM_001168.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301633(uc002jvd.1 uc010dhl.1 uc010dhk.1 uc002jvf.3)
    ENST00000350051(uc002jvg.3 uc002jvi.3) ENST00000590925 ENST00000374948(uc002jvc.3 uc002jve.1 uc002jvh.3)
    ENST00000590449 ENST00000592734 ENST00000592115 ENST00000586192 ENST00000587746
    ENST00000591800 ENST00000589892
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate BIRC5:
    hsa-miR-203 hsa-miR-548p hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmidBIRC5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): BIRC5 (NM_001168)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC5
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      QuantiTect SYBR Green Assays in human, mouse, rat BIRC5
      QuantiFast Probe-based Assays in human, mouse, rat BIRC5

    Selected AceView cDNA sequences (see all 516):

    AB154416 BM745616 CR602197 AI290250 BE395154 BE206066 CR607868 CR624931 
    BU628667 BM549522 AW247335 CR621516 BF345645 BM913308 AI190257 L32866 
    AW250013 CR611538 CR612752 AI918307 CR603892 AF077350 BX090708 BF440043 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BIRC5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                -           -           -                     
    SP2:                                -     -     -           -                     
    SP3:                                -     -     -     -     -                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for BIRC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BIRC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCGCTC
    BIRC5 Expression
    About this image


    BIRC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Thymus (Hematopoietic System)
             Thymus
    BIRC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIRC5 Protein Expression

    UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392
    Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly
    expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also
    expressed in various renal cell carcinoma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC5 (see all 10): 
              Lung Cancer in human mouse rat
              Lymphoma in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Cancer Drug Targets in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat BIRC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for BIRC5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Birc51 , 5 baculoviral IAP repeat-containing 51, 5 82.62(n)1
    83.57(a)1
      11 (82.96 cM)5
    117991  NM_009689.21  NP_033819.11 
     1178492515 
    chicken
    (Gallus gallus)
    Aves BIRC51 baculoviral IAP repeat containing 5 65.69(n)
    60.58(a)
      374078  NM_001012318.1  NP_001012318.1 
    lizard
    (Anolis carolinensis)
    Reptilia BIRC56
    baculoviral IAP repeat containing 5
    57(a)
    1 ↔ 1
    2(102264153-102273198)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF442492.12   -- 75.69(n)    AF442492.1 
    zebrafish
    (Danio rerio)
    Actinopterygii birc5a2 baculoviral IAP repeat-containing 5A 70.33(n)   373110  AY057057.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Det6
    Deterin
    31(a)
    1 ↔ 1
    3R(12975391-12976177)


    ENSEMBL Gene Tree for BIRC5 (if available)
    TreeFam Gene Tree for BIRC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for BIRC5 gene
    6 SIMAP similar genes for BIRC5 using alignment to 11 protein entries:     BIRC5_HUMAN (see all proteins):
    PKP2    ZNF429    FLT3LG    OK/SW-cl.18    NAIP    BIRC7

    BIRC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BIRC5 (see all 381)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178789841,2
    C,F--76213524(+) AGTGCT/CGAGAT 3 -- int11Minor allele frequency- C:0.02NS 174
    rs178786831,2
    C,F--76213642(+) ACGGGA/GTCTCG 3 -- int11Minor allele frequency- G:0.01NS 178
    rs2010919661,2
    C--76218283(+) AAAAA-/ACCAAA 3 -- int10--------
    rs779035111,2
    --76220145(+) TTTTTG/TTTTTT 3 -- ut310--------
    rs1469342911,2
    --77294424(+) CCTGGC/TGACAG 3 -- us2k10--------
    rs1124299981,2
    C,F--77294431(+) ACAGAG/ACAAGA 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1816152201,2
    --77294702(+) TGTGTA/TAGAGA 3 -- us2k10--------
    rs72103471,2
    C,A--77294905(+) gacagC/Agagag 3 -- us2k1 trp312Minor allele frequency- A:0.20NA WA CSA EA 373
    rs37643831,2
    C,F,H--77294997(-) tgcctA/Gtttcc 3 -- us2k1 tfbs326Minor allele frequency- G:0.20NS EA NA WA CSA 2355
    rs1433963101,2
    C--77295086(+) GACATC/TGGGCC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for BIRC5 (76210267 - 76221717 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BIRC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3278n71CNV Loss21882294
    nsv524306CNV Gain19592680
    nsv908876CNV Gain21882294

    Human Gene Mutation Database (HGMD): BIRC5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIRC5
    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603352    OMIM disorders: --

    Selected diseases for BIRC5 (see all 190):    
    About MalaCards
    laryngeal squamous cell carcinoma    cervical carcinosarcoma    vulvar intraepithelial neoplasia    serous cystadenocarcinoma
    ovarian serous cystadenocarcinoma    ovarian germ cell tumor    bladder transitional cell papilloma    malignant peritoneal mesothelioma
    brain stem glioma    cystadenocarcinoma    posterior uveal melanoma    basaloid squamous cell carcinoma
    benign meningioma    laryngitis    salivary gland cancer    brain glioma
    laryngeal carcinoma    neutropenia    oral submucous fibrosis    bullous keratopathy

    15 diseases from the University of Copenhagen DISEASES database for BIRC5:
    Carcinoma     Lung cancer     Urinary bladder cancer     Hepatocellular carcinoma
    Colorectal cancer     Leukemia     Breast cancer     Prostate cancer
    Malignant glioma     Lymphoma     Melanoma     Pancreatic cancer
    Ovarian cancer     Laryngeal carcinoma     Cervical cancer

    BIRC5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for BIRC5 gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 78.7 780 20096120 (7), 20398291 (7), 15359286 (5), 11956993 (5) (see all 99)
    tumors 77.9 1055 11150435 (8), 12569609 (7), 16525657 (6), 12240548 (5) (see all 99)
    bladder cancer 63.5 131 14713774 (7), 16778475 (6), 16635519 (4), 11176843 (4) (see all 58)
    nsclc 59.7 200 19728914 (8), 20346215 (8), 18192073 (7), 16224523 (6) (see all 63)
    hepatocellular carcinoma 58.4 86 15195112 (4), 16086872 (3), 15722574 (3), 20035770 (3) (see all 45)
    colon cancer 57.2 62 19728912 (8), 15685548 (4), 15566647 (4), 12441269 (3) (see all 30)
    metastasis 56.7 169 12168867 (5), 15991282 (4), 17094406 (4), 15062058 (4) (see all 95)
    carcinoma squamous cell 56.6 91 15163019 (3), 16671090 (3), 15922854 (3), 15844613 (3) (see all 65)
    breast cancer 56.5 248 17695451 (7), 16876381 (5), 19228734 (5), 19022237 (5) (see all 99)
    prostate cancer 55.9 118 15076293 (6), 19435906 (6), 15735703 (5), 20501415 (5) (see all 45)

    Genetic Association Database (GAD): BIRC5
    Human Genome Epidemiology (HuGE) Navigator: BIRC5 (26 documents)

    Export disorders for BIRC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BIRC5 gene, integrated from 10 sources (see all 2295):
    (articles sorted by number of sources associating them with BIRC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells. (PubMed id 16762323)1, 2, 9 Cao L.... Yu L. (Biochem. Biophys. Res. Commun. 2006)
    2. Survivin and the inner centromere protein INCENP show similar cell- cycle localization and gene knockout phenotype. (PubMed id 11084331)1, 2, 9 Uren A.G....Choo K.H. (Curr. Biol. 2000)
    3. Polymorphisms in the survivin promoter are associated with age of onset of ovarian cancer. (PubMed id 20057973)1, 4, 9 Han C.H....Wang L.E. (Int J Clin Exp Med 2009)
    4. Polymorphisms in the survivin gene and the risk of lung cancer. (PubMed id 17961802)1, 4, 9 Jang J.S....Park J.Y. (Lung Cancer 2008)
    5. [Correlation of -31G/C polymorphisms of survivin promoter to tumorigenesis of gastric carcinoma]. (PubMed id 18334114)1, 4, 9 Cheng Z.J....Huang S.J. (Ai Zheng 2008)
    6. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. (PubMed id 16427043)1, 2, 9 Chang J.-L.... Chen C.-M. (Exp. Cell Res. 2006)
    7. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. (PubMed id 10626797)1, 2, 9 Mahotka C.... Gerharz C.D. (Cancer Res. 1999)
    8. Survivin -31G/C promoter polymorphism and sporadic colorectal cancer. (PubMed id 18946675)1, 4, 9 Gazouli M....Nikiteas N. (Int J Colorectal Dis 2009)
    9. Polymorphisms of survivin promoter are associated with risk of esophageal squamous cell carcinoma. (PubMed id 19352701)1, 4, 9 Yang X....Bai Y. (J. Cancer Res. Clin. Oncol. 2009)
    10. Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. (PubMed id 17993464)1, 2, 9 Gagarina V.... Hall D.J. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 332 HGNC: 593 AceView: BIRC5andAFMID Ensembl:ENSG00000089685 euGenes: HUgn332
    ECgene: BIRC5 Kegg: 332 H-InvDB: BIRC5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BIRC5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/birc5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BIRC5 gene:
    Search GeneIP for patents involving BIRC5

    Licensable Technologies for BIRC5 gene:
     Salk Institute: Method and Composition for the Inhibition of Mitosis
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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