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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BIRC5 Gene

protein-coding GIFtS: 68
GCID: GC17P076210

baculoviral IAP repeat containing 5

(Previous names: apoptosis inhibitor 4, baculoviral IAP repeat-containing...)
(Previous symbol: API4)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Baculoviral IAP Repeat Containing 5¹ ²		Baculoviral IAP Repeat-Containing 5¹
API4¹ ² ³ ⁵		Survivin¹
Apoptosis Inhibitor 4¹ ² ³		Baculoviral IAP Repeat-Containing Protein 5²
EPR-1¹ ²		Survivin Variant 3 Alpha²
Apoptosis Inhibitor Survivin² ³		IAP4³

External Ids:	HGNC: 593¹	Entrez Gene: 332²	Ensembl: ENSG00000089685⁷	OMIM: 603352⁵	UniProtKB: O15392³

Export aliases for BIRC5 gene to outside databases

Previous GC identifers: GC17M076124 GC17P079197 GC17P076671 GC17P076808 GC17P076809 GC17P073722 GC17P071634

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BIRC5:

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that

prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but

this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger

domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively

spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392

Function: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component

of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during

mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to

different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in

the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role

in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to

microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3

transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and

isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic

effects when compared with the displayed wild-type isoform

Gene Wiki entry for BIRC5 (Survivin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BIRC5 gene promoter:
Sp1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BIRC5 promoter sequence

Search SABiosciences Chromatin IP Primers for BIRC5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

BIRC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC5 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P076210: view genomic region (about GC identifiers)

Start:	76,210,267 bp from pter	End:	76,221,717 bp from pter
Size:	11,451 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 5

Size: 142 amino acids; 16389 Da

Subunit: Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The

monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of

enhancing tubulin stability in cells. When phosphorylated, interacts with HBXIP; the resulting complex binds

pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC)

composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8

and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the

cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129

interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form

interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with

BIRC6/bruce

Subcellular location: Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.

Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase

through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at

telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129

directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated

nuclear export

Developmental stage: Expression is cell cycle-dependent and peaks at mitosis

6/21 PDB 3D structures from and Proteopedia for BIRC5 (see all 21):

1E31 (3D)

1F3H (3D)

1XOX (3D)

2QFA (3D)

2RAW (3D)

2RAX (3D)

Secondary accessions: A2SUH6 B2R4R1 Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8

Alternative splicing: 7 isoforms: O15392-1 O15392-2 O15392-3 O15392-4 O15392-5 O15392-6 O15392-7

Explore the universe of human proteins at neXtProt for BIRC5: NX_O15392

Post-translational modifications:

Ubiquitination is required for centrosomal targeting¹

In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes.

Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities¹

Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers

which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3

transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its

interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15392

BIRC5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001012270.1 NP_001012271.1 NP_001159.2

ENSEMBL proteins:

ENSP00000301633 ENSP00000324180 ENSP00000465671 ENSP00000364086 ENSP00000465868

ENSP00000466617 ENSP00000467336 ENSP00000466063 ENSP00000466675 ENSP00000467259

Reactome Protein details: O15392
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for BIRC5 (Survivin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: BIRC5 OriGene Protein Over-expression Lysate (see all 3): BIRC5 OriGene Custom Protein Services for BIRC5
	GenScript Custom Purified and Recombinant Proteins Services for BIRC5
	Novus Biologicals BIRC5 Proteins Novus Biologicals BIRC5 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for BIRC5
	Browse Proteins at Uscn

Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	IDA	16322459
GO:0000775	chromosome, centromeric region	IDA	11084331
GO:0000777	condensed chromosome kinetochore	IDA	15665297
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--

BIRC5 for ontologies About GeneDecksing

BIRC5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BIRC5
	R&D Systems Antibodies for BIRC5 (Survivin)
	Cell Signaling Technology (CST) Antibodies for BIRC5 (survivin)
	OriGene Antibodies (see all 23): BIRC5 OriGene Custom Antibody Services for BIRC5
	GenScript Custom Superior Antibodies Services for BIRC5
	Novus Biologicals BIRC5 Antibodies
	Abcam antibodies for BIRC5
	Browse Antibodies at Uscn
	ThermoFisher Antibody for BIRC5

Assay Products for BIRC5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for BIRC5 (Survivin) (see all)
	GenScript Custom Assay Services for BIRC5
	Cell Signaling Technology (CST) Sandwich ELISA Kits for BIRC5 (survivin)
	Enzo Life Sciences assays for BIRC5
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BIRC5 for domains About GeneDecksing

1 InterPro domain/family:

IPR001370 BIR

Graphical View of Domain Structure for InterPro Entry O15392

ProtoNet protein and cluster: O15392

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392

Domain: The BIR repeat is necessary and sufficient for HBXIP binding

Similarity: Belongs to the IAP family

Similarity: Contains 1 BIR repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: