V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

BIRC5 Gene

protein-coding GIFtS: 62

GC17P073722

baculoviral IAP repeat-containing 5
(Previous name: apoptosis inhibitor 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: API4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
API4 ^², ³
EPR-1 ^¹, ²
IAP4 ^³

Descriptions
Apoptosis inhibitor 4 ^¹, ², ³
Apoptosis inhibitor survivin ^³
baculoviral IAP repeat-containing 5 ^²
baculoviral IAP repeat-containing protein 5 ^²
survivin variant 3 alpha ^²

External Ids
HGNC: 593¹
Entrez Gene: 332²
UniProtKB: O15392³
Ensembl: ENSG00000089685⁷

Search outside databases for aliases for BIRC5 gene

Previous GC identifers: GC17M076124 GC17P079197 GC17P076671 GC17P076808 GC17P076809

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BIRC5:

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative

regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple

baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR

domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high

during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are

involved in the regulation of this gene's expression. At least four transcript variants

encoding distinct isoforms have been found for this gene, but the full-length natures of only

three of them have been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392

Function: May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M

phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal

passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has

essential functions at the centromere in ensuring correct chromosome alignment and segregation and

is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3

do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its

anti-apoptotic effects when compared with the displayed wild-type isoform

Gene Wiki entry for BIRC5 (Survivin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BIRC5 gene

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25

BIRC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P073722: (about GC identifiers)

Start:	73,721,872 bp from pter
End:	73,733,311 bp from pter
Size:	11,440 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 5

Size: 142 amino acids; 16390 Da

Subunit: Homodimer. When phosphorylated, interacts with HBXIP; the resulting complex binds

pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the CPC at

least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with EVI5

Subcellular location: Cytoplasm. Nucleus. Centromere. Note=Localizes on chromosome arms and inner

centromeres from prophase through metaphase and then transferring to the spindle midzone and

midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes

PDB structures from and Proteopedia :

1E31 (3D)

1F3H (3D)

1XOX (3D)

2QFA (3D)

2RAW (3D)

2RAX (3D)

Secondary accessions: Q2I3N8 Q4VGX0 Q53F61 Q5MGC6 Q6FHL2 Q75SP2 Q9P2W8

Alternative splicing: 7 isoforms: O15392-1 O15392-2 O15392-3 O15392-4 O15392-5 O15392-6 O15392-7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001012270.1 NP_001012271.1 NP_001159.2

ENSEMBL proteins:

ENSP00000364086 ENSP00000301633 ENSP00000324180

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BIRC5 (Survivin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Survivin 2B, Survivin , Survivin DEx3)
	Human Recombinant Proteins from Abnova (BIRC5)

OriGene Purified Recombinant Human Protein: BIRC5

5/13 Gene Ontology (GO) cellular component terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	ISS	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005694	chromosome	IEA	--
GO:0005730	NOT nucleolus	IDA	18029348

About this table

Antibodies for BIRC5:

	Invitrogen Antibodies for BIRC5
	Millipore Mono- and Polyclonal Antibodies for the study of BIRC5
	Sigma-Aldrich Antibody Arrays and Antibodies for BIRC5
	R&D Systems Antibodies for BIRC5 (Survivin)
	Cell Signaling Technology (CST) Antibodies for BIRC5 (survivin)
	Antibodies from Abcam (Survivin 2B, Survivin , Survivin DEx3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BIRC5)
	Novus Biologicals Antibodies for BIRC5

Assays for BIRC5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for BIRC5 (Survivin) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for BIRC5 (survivin)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15392

ProtoNet protein and cluster: O15392

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392

Domain: The BIR repeat is necessary and sufficient for HBXIP binding

Similarity: Belongs to the IAP family

Similarity: Contains 1 BIR repeat

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BIRC5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BIRC5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001012270

Applied Biosystems Silencer® siRNAs for BIRC5

Sigma-Aldrich siRNA and siRNA Panels for BIRC5

Sigma-Aldrich shRNA Panels and shRNA for BIRC5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BIRC5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001012270
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001012270
untagged cDNA clones in CMV expression vector (see all 3): NM_001012270

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001012271

UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392

Function: May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M

phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal

passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has

essential functions at the centromere in ensuring correct chromosome alignment and segregation and

is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3

do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its

anti-apoptotic effects when compared with the displayed wild-type isoform

7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Birc5):

cellular	embryogenesis	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	normal

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008017	microtubule binding	ISS	--
GO:0008270	zinc ion binding	ISS	--
GO:0042803	protein homodimerization activity	ISS	--
GO:0043027	caspase inhibitor activity	ISS	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for BIRC5 (Your Favorite Gene powered by Ingenuity)

Angiopoietin Signaling
p53 Signaling

GeneDecks BIRC5 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BIRC5

5/119 Interacting proteins for BIRC5 (O15392^{1, 2} ENSP00000301633³) via UniProtKB, MINT, and/or STRING (see all 119 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INCENP	Q9NQS7², ENSP00000278849³	MINT-4509563 MINT-4509570 MINT-77929 STRING (score=.999)
CASP9	P55211¹, ENSP00000330237³	EBI-518823, EBI-516799 STRING (score=.971)
CDC2	P06493¹, ENSP00000362917³	EBI-518823, EBI-444308 STRING (score=.94)
AURKB	Q96GD4¹^,², ENSP00000313950³	EBI-518842, EBI-624291 MINT-4509558 MINT-4509592 MINT-4509580 EBI-518842, EBI-624291 MINT-4509558 MINT-4509592 MINT-4509580 STRING (score=.999)
CDCA8	Q53HL2¹^,², ENSP00000316121³	EBI-518842, EBI-979174 MINT-4509524 MINT-4509575 EBI-518842, EBI-979174 MINT-4509524 MINT-4509575 STRING (score=.999)

About this table

5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	ISS	--
GO:0000910	cytokinesis	ISS	--
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	ISS	--
GO:0007049	cell cycle	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BIRC5
10/58 Novoseek chemical compound relationships for BIRC5 gene (see all 58 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ciap2	71.44	9	17255535 (2), 15380346 (2), 17208224 (2), 16957584 (1) (see all 5)
ponicidin	65.15	5	19330074 (2), 16537182 (2), 17049940 (1)
purvalanol a	64.93	2	17011457 (1), 14988404 (1)
noxa	61.85	8	18712736 (1), 14508115 (1), 17569614 (1), 17038534 (1) (see all 8)
tetra-o-methylnordihydroguaiaretic acid	61.38	3	17454637 (2), 16890802 (1)
deguelin	56.39	14	18089792 (5), 18593368 (4), 17035597 (2)
17-(allylamino)-17-demethoxygeldanamycin	52.11	6	17510430 (2), 16432177 (1), 18827603 (1)
ciap1	49.75	3	15665297 (2), 16957584 (1)
hedamycin	49.26	13	15637054 (6), 17392340 (1)
lipofectamine	49.24	2	16224667 (1), 18077908 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BIRC5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BIRC5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001012270

Sigma-Aldrich siRNA and siRNA Panels for BIRC5

Sigma-Aldrich shRNA Panels and shRNA for BIRC5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001012270 NM_001012271 NM_001168

REFSEQ mRNAs for BIRC5 gene (3 alternative transcripts):

NM_001012270.1 NM_001012271.1 NM_001168.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001012270 NM_001012271 NM_001168

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001012270
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001012270
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001012270

Additional cDNA sequence:

AB028869.1 AB154416.1 AF077350.1 AF086186.1 AK223428.1 AK301793.1 AK311917.1 AY830084.1

AY927772.1 BC000784.2 BC008718.2 BC034148.1 BC065497.1 CR541740.1 CR592187.1 CR593999.1

CR602197.1 CR603892.1 CR605755.1 CR607868.1 CR612752.1 CR619419.1 CR621516.1 CR624931.1

DQ227257.1 DQ310375.1 DQ310376.1 DQ310377.1 DQ310378.1 DQ310379.1 DQ508245.1 DQ508246.1

DQ508247.1 DQ508248.1 DQ508249.1 L26245.1 L32866.1

19 DOTS entries:

DT.100722905 DT.100869111 DT.453571 DT.100655157 DT.100637750 DT.100038157 DT.120915604 DT.92462361

DT.100733093 DT.40106138 DT.100655167 DT.100853297 DT.101980495 DT.95162876 DT.95162880 DT.97775214

DT.100655161 DT.120915600 DT.121117749

24/516 AceView cDNA sequences (see all 516 ):

L32866 BF953213 CR611538 CR612752 CR619419 BE858078 BF440043 AI718433

BE395154 AI936819 CR621516 CR593999 AI364358 CR602197 CR603892 BQ962876

BF953215 AF077350 CR624931 AW247335 AF086186 AI220081 BF345645 BE206066

highest scoring ESTs for BIRC5:

AA159549 AA307813 AA307937 AA315266 AA351941 AA459505 AA460859 AA506522 AA931155 AB028869

Unigene Cluster for BIRC5:

Baculoviral IAP repeat-containing 5

Hs.514527 [show with all ESTs]

Unigene Representative Sequence: NM_001012271

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC5 (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c
SP1:											-				-				-
SP2:											-		-		-				-
SP3:											-		-		-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for BIRC5

3 Ensembl transcripts including schematic representations:

ENST00000374948 ENST00000301633 ENST00000350051

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BIRC5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BIRC5

¹ / ² / ³

7 probe-sets matching BIRC5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40532_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U75285	0.20	1.00	0.72	1
210334_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB028869	0.80	1.00	0.91	1
202094_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA648913	0.60	1.00	0.82	1
202095_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001168	0.60	1.00	0.82	1
210334_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202094_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202095_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.514527
Expression variation in blood from EXPOLDB for BIRC5
UniProtKB/Swiss-Prot: BIRC5_HUMAN, O15392
Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain.
Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in
high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BIRC5 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BIRC5¹	--	baculoviral IAP repeat-containing 5	90.14(n) 90.85(a)	442936 NM_001003348.1 NP_001003348.1
chimpanzee (Pan troglodytes)	BIRC5¹	--	baculoviral IAP repeat-containing 5	99.53(n) 98.59(a)	455276 XM_001156931.1 XP_001156931.1
cow (Bos taurus)	BIRC5¹	--	baculoviral IAP repeat-containing 5	90.14(n) 90.14(a)	414925 NM_001001855.2 NP_001001855.2
mouse (Mus musculus)	Birc5^{1, 5}	11⁵	baculoviral IAP repeat-containing 5^{1, 5}	82.62(n)¹ 83.57(a)¹	11799¹ NM_009689.2¹ NP_033819.1¹ AB013819⁵ AB036741⁵ (see all 19)
chicken (Gallus gallus)	BIRC5¹	--	baculoviral IAP repeat-containing 5 (survivin)	65.93(n) 61.03(a)	374078 NM_001012318.1 NP_001012318.1

About this table Species with no ortholog for BIRC5

ENSEMBL Gene Tree for BIRC5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/152 NCBI SNPs in BIRC5 are shown (see all 152 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 73)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2239680^1,2	C,F,H,O	73731378(+)	`TGCTCT/CTAAGG`	3	--	ut3¹ ese³		20	EA NA NS EU WA	3378
	rs1042541^1,2	A,C,F,H	73732965(+)	`TGGCTG/ACCAGC`	3	--	ut3¹ ese³		16	MN NS EU EA WA NA	1746
	rs1042489^1,2	A,C,F,H	73731801(+)	`GTCCCT/CGGCTC`	3	--	ut3¹ ese³		9	EA MN EU WA NA	2316
	rs1042542^1,2	A,C,F,H	73733023(+)	`CTAAGC/TGCAAC`	3	--	ut3¹ ese³		6	MN NS EU EA WA	764
	rs2661694^1,2	C,F,H	73732603(+)	`TATTTC/ATGCCA`	3	--	ut3¹		5	NS EU EA WA	594
--	rs8074228^1,2	A,C,F	73733491(+)	`aaaaaA/AA /T/TTttttt`	3	--	ng3¹		1	NS	166
	rs3764383^1,2	C,F,H	73720446(-)	`tgcctA/Gtttcc`	3	--	ng5¹ tfbs³		4	EU EA WA	420
	rs2071214^1,2	C,F,H	73731186(+)	`CTGCGA/GAGAAA`	3	E/K R/R	mis¹ syn¹		20	EA NA NS EU WA	2982
	rs9904341^1,2	C,F,H	73721962(+)	`ATCGCG/CGGACC`	3	--	ut5¹ ese³		16	EA NA MN NS EU	1742
	rs4789560^1,2	A,C,F	73733057(+)	`ATGTCC/TACATG`	3	--	ut3¹ ese³		1	NS	158

About this table

HapMap Linkage Disequilibrium images for BIRC5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603352

10/90 Novoseek disease relationships for BIRC5 gene (see all 90 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	77.41	665	15359286 (5), 17167980 (5), 11956993 (5), 16731740 (4) (see all 99)
tumors	76.82	953	11150435 (8), 12569609 (7), 16525657 (6), 12240548 (5) (see all 99)
bladder cancer	61.83	113	14713774 (7), 16778475 (6), 16635519 (4), 11176843 (4) (see all 48)
nsclc	57.92	143	18192073 (7), 16224523 (6), 16320585 (6), 15163019 (5) (see all 51)
hepatocellular carcinoma	56.01	64	15195112 (4), 16086872 (3), 18296918 (3), 19173802 (3) (see all 35)
metastasis	55.90	146	12168867 (5), 15991282 (4), 17094406 (4), 15062058 (4) (see all 83)
laryngeal squamous cell carcinoma	55.59	23	18998509 (3), 12174930 (2), 15279637 (2), 16375115 (2) (see all 12)
colon cancer	55.40	45	15685548 (4), 15566647 (4), 12441269 (3), 17270149 (3) (see all 24)
prostate cancer	54.73	101	15076293 (6), 19435906 (5), 15735703 (5), 14724567 (4) (see all 39)
breast cancer	54.60	217	17695451 (7), 16876381 (5), 19228734 (5), 18701842 (5) (see all 87)

About this table

Human Genome Epidemiology Navigator: BIRC5 (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1572 PubMed articles for BIRC5 gene (see all 1572 ):

Survivin and the inner centromere protein INCENP show similar cell- cycle localization and gene knockout phenotype. (PubMed id 11084331)^{1, 3, 4} Uren A.G....Choo K.H. (2000)
Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. (PubMed id 16427043)^{1, 3, 4} Chang J.-L.... Chen C.-M. (2006)
Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. (PubMed id 10626797)^{1, 3, 4} Mahotka C.... Gerharz C.D. (1999)
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. (PubMed id 9256286)^{1, 3, 4} Ambrosini G.... Altieri D.C. (1997)
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. (PubMed id 16239925)^{1, 3, 4} Vader G.... Lens S.M.A. (2006)
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PubMed id 15249581)^{1, 3, 4} Gassmann R.... Earnshaw W.C. (2004)
Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. (PubMed id 16291752)^{1, 3, 4} Noton E.A.... Wheatley S.P. (2006)
EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PubMed id 16764853)^{1, 3, 4} Faitar S.L.... Cowell J.K. (2006)
Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells. (PubMed id 16329164)^{1, 3, 4} Zheng W.... Yang S. (2005)
Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres. (PubMed id 16436504)^{3, 4} Lens S.M.A....Medema R.H. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 332	HGNC: 593	AceView: BIRC5andAFMID	Ensembl:ENSG00000089685	euGenes: HUgn332
ECgene: BIRC5	H-InvDB: BIRC5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BIRC5	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/birc5/

Licensable Technologies for BIRC5
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for BIRC5 gene:

Salk Institute:

Method and Composition for the Inhibition of Mitosis

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BIRC5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BIRC5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BIRC5		Antibodies for BIRC5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BIRC5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BIRC5)
	Antibodies (BIRC5)
	Chimera RNAi (BIRC5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for BIRC5 (survivin)

	Recombinant Proteins (Survivin 2B, Survivin , Survivin DEx3)
	Antibodies (Survivin 2B, Survivin , Survivin DEx3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for BIRC5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BIRC5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BIRC5 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

BIRC5 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for BIRC5

Summaries
for BIRC5

Genomic Location
for BIRC5

Proteins
for BIRC5

Protein Domains/
Families
for BIRC5

Gene Function
for BIRC5

Pathways & Interactions
for BIRC5

Drugs & Compounds
for BIRC5

Transcripts
for BIRC5

Expression
for BIRC5

Orthologs
for BIRC5

Paralogs
for BIRC5

SNPs/Variants
for BIRC5

Disorders & Mutations
for BIRC5

Medical News
for BIRC5

Publications
for BIRC5

Search for BIRC5

Genome Databases showing BIRC5

Other Databases showing BIRC5

Specialized Databases showing BIRC5

Licensable Technologies
for BIRC5

Services
for BIRC5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BIRC5 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor BIRC5

Summariesfor BIRC5

Genomic Locationfor BIRC5

Proteinsfor BIRC5

Protein Domains/Familiesfor BIRC5

Gene Functionfor BIRC5

Pathways & Interactionsfor BIRC5

Drugs & Compoundsfor BIRC5

Transcriptsfor BIRC5

Expression for BIRC5

Orthologsfor BIRC5

Paralogsfor BIRC5

SNPs/Variantsfor BIRC5

Disorders & Mutationsfor BIRC5

Medical Newsfor BIRC5

Publicationsfor BIRC5

Search for BIRC5

Genome Databases showing BIRC5

Other Databases showing BIRC5

Specialized Databases showing BIRC5

Licensable Technologiesfor BIRC5

Servicesfor BIRC5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BIRC5

Summaries
for BIRC5

Genomic Location
for BIRC5

Proteins
for BIRC5

Protein Domains/
Families
for BIRC5

Gene Function
for BIRC5

Pathways & Interactions
for BIRC5

Drugs & Compounds
for BIRC5

Transcripts
for BIRC5

Expression
for BIRC5

Orthologs
for BIRC5

Paralogs
for BIRC5

SNPs/Variants
for BIRC5

Disorders & Mutations
for BIRC5

Medical News
for BIRC5

Publications
for BIRC5

Licensable Technologies
for BIRC5

Services
for BIRC5