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Aliases for BIRC5 Gene

Aliases for BIRC5 Gene

  • Baculoviral IAP Repeat Containing 5 2 3 5
  • Apoptosis Inhibitor 4 2 3 4
  • Apoptosis Inhibitor Survivin 3 4
  • Survivin Variant 3 Alpha 2 3
  • API4 3 4
  • Baculoviral IAP Repeat-Containing 5 2
  • EPR-1 3
  • IAP4 4

External Ids for BIRC5 Gene

Previous HGNC Symbols for BIRC5 Gene

  • API4

Previous GeneCards Identifiers for BIRC5 Gene

  • GC17M076124
  • GC17P079197
  • GC17P076671
  • GC17P076808
  • GC17P076809
  • GC17P073722
  • GC17P076210
  • GC17P071634

Summaries for BIRC5 Gene

Entrez Gene Summary for BIRC5 Gene

  • This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for BIRC5 Gene

BIRC5 (Baculoviral IAP Repeat Containing 5) is a Protein Coding gene. Diseases associated with BIRC5 include Malignant Peritoneal Mesothelioma and Vulvar Intraepithelial Neoplasia. Among its related pathways are FOXM1 transcription factor network and Mitotic Metaphase and Anaphase. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for BIRC5 Gene

  • Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Gene Wiki entry for BIRC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC5 Gene

Genomics for BIRC5 Gene

Regulatory Elements for BIRC5 Gene

Enhancers for BIRC5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BIRC5 on UCSC Golden Path with GeneCards custom track

Promoters for BIRC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BIRC5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BIRC5 gene promoter:

Genomic Location for BIRC5 Gene

Chromosome:
17
Start:
78,214,186 bp from pter
End:
78,225,636 bp from pter
Size:
11,451 bases
Orientation:
Plus strand

Genomic View for BIRC5 Gene

Genes around BIRC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC5 Gene

Proteins for BIRC5 Gene

  • Protein details for BIRC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15392-BIRC5_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 5
    Protein Accession:
    O15392
    Secondary Accessions:
    • A2SUH6
    • B2R4R1
    • Q2I3N8
    • Q4VGX0
    • Q53F61
    • Q5MGC6
    • Q6FHL2
    • Q75SP2
    • Q9P2W8

    Protein attributes for BIRC5 Gene

    Size:
    142 amino acids
    Molecular mass:
    16389 Da
    Quaternary structure:
    • Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for BIRC5 Gene

    Alternative splice isoforms for BIRC5 Gene

neXtProt entry for BIRC5 Gene

Proteomics data for BIRC5 Gene at MOPED

Post-translational modifications for BIRC5 Gene

  • Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
  • In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes (PubMed:14610074). Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities (PubMed:21252625). Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity (PubMed:24866247).
  • Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
  • Ubiquitination at Lys 23
  • Modification sites at PhosphoSitePlus

Assay Products

  • Enzo Life Sciences assays for BIRC5
  • Cloud-Clone Corp Assay Kits for BIRC5

No data available for DME Specific Peptides for BIRC5 Gene

Domains & Families for BIRC5 Gene

Gene Families for BIRC5 Gene

Protein Domains for BIRC5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15392

UniProtKB/Swiss-Prot:

BIRC5_HUMAN :
  • The BIR repeat is necessary and sufficient for LAMTOR5 binding.
  • Belongs to the IAP family.
  • Contains 1 BIR repeat.
Domain:
  • The BIR repeat is necessary and sufficient for LAMTOR5 binding.
Family:
  • Belongs to the IAP family.
Similarity:
  • Contains 1 BIR repeat.
genes like me logo Genes that share domains with BIRC5: view

Function for BIRC5 Gene

Molecular function for BIRC5 Gene

UniProtKB/Swiss-Prot Function:
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
UniProtKB/Swiss-Prot Induction:
Up-regulated by COMP.

Gene Ontology (GO) - Molecular Function for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA,IPI 16291752
genes like me logo Genes that share ontologies with BIRC5: view
genes like me logo Genes that share phenotypes with BIRC5: view

Animal Models for BIRC5 Gene

MGI Knock Outs for BIRC5:

Animal Model Products

  • Taconic Biosciences Mouse Models for BIRC5

miRNA for BIRC5 Gene

miRTarBase miRNAs that target BIRC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC5 Gene

Localization for BIRC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC5 Gene

Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC5 Gene COMPARTMENTS Subcellular localization image for BIRC5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 11084331
GO:0005634 nucleus IDA 15665297
GO:0005737 cytoplasm IDA 9256286
GO:0005829 cytosol IDA,TAS --
GO:0005876 spindle microtubule IDA 9859993
genes like me logo Genes that share ontologies with BIRC5: view

Pathways & Interactions for BIRC5 Gene

genes like me logo Genes that share pathways with BIRC5: view

SIGNOR curated interactions for BIRC5 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006468 protein phosphorylation IDA 21252625
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division TAS 16291752
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with BIRC5: view

Drugs & Compounds for BIRC5 Gene

(88) Drugs for BIRC5 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Inhibition, inhibitor, Biomarker Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Paclitaxel Approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 2655
LY2181308 Investigational Pharma antisense, Inhibitor, Target Survivin inhibitors 0
HGS1029 Pharma 0
SPC-3042 Pharma 0

(76) Additional Compounds for BIRC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BIRC5: view

Transcripts for BIRC5 Gene

Unigene Clusters for BIRC5 Gene

Baculoviral IAP repeat containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for BIRC5 Gene

GeneLoc Exon Structure for
BIRC5
ECgene alternative splicing isoforms for
BIRC5

Expression for BIRC5 Gene

mRNA expression in normal human tissues for BIRC5 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC5 Gene

This gene is overexpressed in Testis (x14.6).

Protein differential expression in normal tissues from HIPED for BIRC5 Gene

This gene is overexpressed in Stomach (53.4) and Plasma (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIRC5 Gene



SOURCE GeneReport for Unigene cluster for BIRC5 Gene Hs.744872

mRNA Expression by UniProt/SwissProt for BIRC5 Gene

O15392-BIRC5_HUMAN
Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
genes like me logo Genes that share expression patterns with BIRC5: view

Protein tissue co-expression partners for BIRC5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BIRC5 Gene

Orthologs for BIRC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BIRC5 35
  • 90.14 (n)
  • 90.14 (a)
BIRC5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC5 35
  • 90.14 (n)
  • 90.85 (a)
BIRC5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc5 35
  • 82.62 (n)
  • 83.57 (a)
Birc5 16
Birc5 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIRC5 35
  • 98.84 (n)
  • 98.26 (a)
BIRC5 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Birc5 35
  • 81.32 (n)
  • 82.98 (a)
oppossum
(Monodelphis domestica)
Mammalia BIRC5 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC5 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves BIRC5 35
  • 65.69 (n)
  • 60.58 (a)
BIRC5 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIRC5 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia birc5.2 35
  • 64.2 (n)
  • 57.78 (a)
Str.8111 35
zebrafish
(Danio rerio)
Actinopterygii birc5a 35
  • 58.01 (n)
  • 54.33 (a)
birc5a 36
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1470 35
fruit fly
(Drosophila melanogaster)
Insecta Det 36
  • 31 (a)
OneToOne
Species with no ortholog for BIRC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC5 Gene

ENSEMBL:
Gene Tree for BIRC5 (if available)
TreeFam:
Gene Tree for BIRC5 (if available)

Paralogs for BIRC5 Gene

genes like me logo Genes that share paralogs with BIRC5: view

No data available for Paralogs for BIRC5 Gene

Variants for BIRC5 Gene

Sequence variations from dbSNP and Humsavar for BIRC5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2071214 - 78,223,510(+) CTGCG(A/G)AGAAA nc-transcript-variant, reference, synonymous-codon, missense
rs1042489 -- 78,224,125(+) GTCCC(C/T)GGCTC nc-transcript-variant, utr-variant-3-prime
rs1042541 -- 78,225,289(+) TGGCT(A/G)CCAGC nc-transcript-variant, utr-variant-3-prime
rs1042542 -- 78,225,347(+) CTAAG(C/T)GCAAC nc-transcript-variant, utr-variant-3-prime
rs2467572 -- 78,220,745(+) GAGAC(A/G)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BIRC5 Gene

Variant ID Type Subtype PubMed ID
dgv3278n71 CNV Loss 21882294
nsv524306 CNV Gain 19592680
nsv908876 CNV Gain 21882294

Variation tolerance for BIRC5 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BIRC5 Gene

Human Gene Mutation Database (HGMD)
BIRC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC5 Gene

Disorders for BIRC5 Gene

MalaCards: The human disease database

(31) MalaCards diseases for BIRC5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant peritoneal mesothelioma
  • malignant mesothelioma of peritoneum
vulvar intraepithelial neoplasia
  • vulvar intraepithelial tumor
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
childhood malignant schwannoma
  • pediatric mpnst
adenocarcinoma
  • adenocarcinoma nos
- elite association - COSMIC cancer census association via MalaCards
Search BIRC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BIRC5

Genetic Association Database (GAD)
BIRC5
Human Genome Epidemiology (HuGE) Navigator
BIRC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIRC5
genes like me logo Genes that share disorders with BIRC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC5 Gene

Publications for BIRC5 Gene

  1. Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells. (PMID: 16762323) Cao L. … Yu L. (Biochem. Biophys. Res. Commun. 2006) 3 4 23 67
  2. Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU. (PMID: 19621386) Liu G. … Chakrabarty S. (Int. J. Cancer 2010) 3 23
  3. Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells. (PMID: 19781773) Ito S. … Ishida Y. (Leuk. Res. 2010) 3 23
  4. Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells. (PMID: 19887369) Okuya M. … Inaba T. (J. Biol. Chem. 2010) 3 23
  5. Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells. (PMID: 19956893) Zhao W. … You H. (Oncol. Rep. 2010) 3 23

Products for BIRC5 Gene

Sources for BIRC5 Gene

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