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BIRC3 Gene

protein-coding   GIFtS: 67
GCID: GC11P102188

Baculoviral IAP Repeat Containing 3

(Previous name: baculoviral IAP repeat-containing 3)
(Previous symbol: API2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Baculoviral IAP Repeat Containing 31 2     HAIP12 5
API21 2 3 5     AIP12
Apoptosis Inhibitor 21 2 3     CIAP22
Inhibitor Of Apoptosis Protein 11 2 3     HIAP12
Baculoviral IAP Repeat-Containing 31 2     MALT22
Mammalian IAP Homolog C1 2     Baculoviral IAP Repeat-Containing Protein 32
TNFR2-TRAF Signaling Complex Protein1 2     c-IAP22
IAP-12 3     C-IAP23
MIHC2 3     EC 6.3.2.-3
RNF492 3     IAP13
IAP Homolog C2 3     hIAP-13
RING Finger Protein 492 3     hIAP13
TNFR2-TRAF-Signaling Complex Protein 12 3     

External Ids:    HGNC: 5911   Entrez Gene: 3302   Ensembl: ENSG000000234457   OMIM: 6017215   UniProtKB: Q134893   

Export aliases for BIRC3 gene to outside databases

Previous GC identifers: GC11P104381 GC11P103545 GC11P102222 GC11P101725 GC11P101693 GC11P098114


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BIRC3 Gene:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis
factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like
proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis
resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats
and a ring finger domain. Transcript variants encoding the same isoform have been identified. (provided by
RefSeq, Aug 2011)

GeneCards Summary for BIRC3 Gene:
BIRC3 (baculoviral IAP repeat containing 3) is a protein-coding gene. Diseases associated with BIRC3 include malt lymphoma, and chronic neutrophilic leukemia. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is BIRC7.

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion
and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both
canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator
of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8,
IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like
receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern
recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein
complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.
Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8

Gene Wiki entry for BIRC3 (Baculoviral IAP repeat-containing protein 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the BIRC3 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBIRC3 promoter sequence
   Search Chromatin IP Primers for BIRC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIRC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22

BIRC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P102188:  view genomic region     (about GC identifiers)

Start:
102,188,194 bp from pter      End:
102,210,134 bp from pter
Size:
21,941 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 3  
Size: 604 amino acids; 68372 Da
Subunit: Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The
BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric
complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is
required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1,
RIP2, RIP3, RIP4 and USP19
5 PDB 3D structures from and Proteopedia for BIRC3:
2UVL (3D)        3EB5 (3D)        3EB6 (3D)        3M0A (3D)        3M0D (3D)    
Secondary accessions: Q16628 Q9HC27 Q9UP46

Explore the universe of human proteins at neXtProt for BIRC3: NX_Q13489

Explore proteomics data for BIRC3 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells1
  • Ubiquitination2 at Lys211
  • Modification sites at PhosphoSitePlus

  • See BIRC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001156.1  NP_892007.1  

    ENSEMBL proteins: 
     ENSP00000263464   ENSP00000432907   ENSP00000431718  
    Reactome Protein details: Q13489

    BIRC3 Human Recombinant Protein Products:

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    BIRC3 Antibody Products:

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    BIRC3 Assay Products:

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    Cloud-Clone Corp. ELISAs for BIRC3
    Cloud-Clone Corp. CLIAs for BIRC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BIRC: Baculoviral IAP repeat containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR011029 DEATH-like_dom
     IPR001370 BIR
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q13489

    ProtoNet protein and cluster: Q13489

    3 Blocks protein domains:
    IPB001315 CARD interaction domain
    IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
    Similarity: Belongs to the IAP family
    Similarity: Contains 3 BIR repeats
    Similarity: Contains 1 CARD domain
    Similarity: Contains 1 RING-type zinc finger


    BIRC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC3_HUMAN, Q13489
    Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
    inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion
    and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both
    canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator
    of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
    proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8,
    IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like
    receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern
    recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein
    complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner.
    Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8
    Enzyme regulation: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA16395405
    GO:0005515protein binding IPI11907583
    GO:0008270zinc ion binding IEA--
         
    BIRC3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for BIRC3:
     Decreased Wnt reporter activit  Decreased cilium length after   Decreased viability after Chla  Increased cell death HMECs cel 
     Synthetic lethal with paclitax 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Birc3):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  normal 

    BIRC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BIRC3: Birc3tm1.1Rbr Birc3tm1Rgk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIRC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIRC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIRC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIRC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIRC3:
    hsa-mir-34a-5p (MIRT000071), hsa-mir-98-5p (MIRT027437), hsa-mir-375 (MIRT019771)

    Block miRNA regulation of human, mouse, rat BIRC3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BIRC3:
    hsa-miR-369-3p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidBIRC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BIRC3
    Predesigned siRNA for gene silencing in human, mouse, rat BIRC3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): BIRC3 (NM_182962)
    Sino Biological Human cDNA Clone for BIRC3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BIRC3_HUMAN, Q13489: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2
    extracellular1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    BIRC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BIRC3 About   (see all 30)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    Fas Signaling0.35
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    5Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for BIRC3
        NOD-like Receptor Signaling Pathways
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BIRC3 (see all 12)
        Caspase Cascade
    TWEAK Pathway
    TRAF Pathway
    Molecular Mechanisms of Cancer
    TNFR2 Pathway

    1 Cell Signaling Technology (CST) Pathway for BIRC3
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for BIRC3
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for BIRC3 (see all 12)
        Focal Adhesion
    Apoptosis
    Apoptosis Modulation and Signaling
    TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway

    1 Sino Biological Pathway for BIRC3
        Death Receptor Signaling

    2 Reactome Pathways for BIRC3
        IKK complex recruitment mediated by RIP1
    NOD1/2 Signaling Pathway


    Selected Kegg Pathways  (Kegg details for BIRC3) (see all 10):
        NF-kappa B signaling pathway
    Ubiquitin mediated proteolysis
    Apoptosis
    Focal adhesion
    NOD-like receptor signaling pathway


    BIRC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC3 (see all 13): 
              NFKB Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BIRC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIRC3 (Q134891, 3 ENSP000002634644) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5721, 3, ENSP000002162744EBI-517709,EBI-298250 I2D: score=1 STRING: ENSP00000216274
    TRAF2Q129331, 3, ENSP000002476684EBI-517709,EBI-355744 I2D: score=9 STRING: ENSP00000247668
    RIPK2O433531, 3, ENSP000002207514EBI-517709,EBI-358522 I2D: score=2 STRING: ENSP00000220751
    RIPK1Q135461, 3, ENSP000002598084EBI-517709,EBI-358507 I2D: score=2 STRING: ENSP00000259808
    CASP3P425743, ENSP000003110324I2D: score=6 STRING: ENSP00000311032
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006915apoptotic process IEA--
    GO:0007166cell surface receptor signaling pathway TAS8548810
    GO:0007283spermatogenesis IEA--

    BIRC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIRC3

    Selected Novoseek inferred chemical compound relationships for BIRC3 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap2 95.4 64 17972100 (7), 20385093 (7), 16115895 (4), 16144937 (4) (see all 16)
    ciap1 93.7 38 15265700 (8), 20097753 (4), 18570872 (3), 17972100 (2) (see all 12)
    pdtc 49.7 5 12269771 (2), 14527959 (1)
    curcumin 44.5 5 16243823 (1), 17640567 (1), 16219905 (1), 15911101 (1) (see all 5)
    ly294002 43.8 2 14762343 (1), 19051078 (1)
    mg 132 41.9 1 14527959 (1)
    parthenolide 41.6 1 11588049 (1)
    triptolide 40.8 2 15972136 (1), 10224110 (1)
    etoposide 40.2 3 15050749 (1), 12243753 (1), 9384571 (1)
    doxorubicin 39.9 8 12926068 (2), 17311258 (1), 18434593 (1), 19746155 (1) (see all 6)



    BIRC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BIRC3 gene (2 alternative transcripts): 
    NM_001165.4  NM_182962.2  

    Unigene Cluster for BIRC3:

    Baculoviral IAP repeat containing 3
    Hs.127799  [show with all ESTs]
    Unigene Representative Sequence: NM_001165
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526421 ENST00000263464(uc001pgx.3) ENST00000528940 ENST00000532808
    ENST00000527309 ENST00000527336

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BIRC3:
    hsa-miR-369-3p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidBIRC3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): BIRC3 (NM_182962)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC3
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat BIRC3
      QuantiFast Probe-based Assays in human, mouse, rat BIRC3

    Additional mRNA sequence: 

    AF070674.1 BC027485.2 BC037420.1 L43346.1 L49432.1 U45878.1 

    5 DOTS entries:

    DT.442857  DT.100813069  DT.92421251  DT.95177781  DT.100690941 

    Selected AceView cDNA sequences (see all 228):

    BU608931 AI978668 AI797582 AV716229 AI823946 AI635855 BU685791 AI678800 
    AW139145 AI827488 BU663663 BU665537 BF339660 BU665522 AI880555 AI767171 
    AA534507 NM_001165 NM_182962 AW591294 AI417860 AA261801 AI572022 BU662287 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                -     -     -                       -                                                   
    SP2:                                                                    -                                                   
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for BIRC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BIRC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTTTAT
    BIRC3 Expression
    About this image

    BIRC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIRC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127799

    UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
    Tissue specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in
    lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC3 (see all 13): 
              NFKB Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BIRC3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Birc31 , 5 baculoviral IAP repeat-containing 31, 5 77.19(n)1
    74.25(a)1
      9 (2.46 cM)5
    117961  NM_007464.31  NP_031490.21 
     78486995 
    chicken
    (Gallus gallus)
    Aves ITA6
    Gallus gallus baculoviral IAP repeat containing 2 ...
    70(a)
    1 → many
    1(181828577-181838749)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    3(192311974-192323674)
    zebrafish
    (Danio rerio)
    Actinopterygii birc26
    baculoviral IAP repeat-containing 2
    51(a)
    1 → many
    21(21948887-21966212) ENSDARG00000044619
    fruit fly
    (Drosophila melanogaster)
    Insecta Iap23 anti-apoptosis apoptosis inhibitor 28(a)   2 52D2   --


    ENSEMBL Gene Tree for BIRC3 (if available)
    TreeFam Gene Tree for BIRC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BIRC3 gene
    BIRC72  NLRC42  NAIP2  BIRC22  XIAP2  BIRC82  
    Selected SIMAP similar genes for BIRC3 using alignment to 3 protein entries:     BIRC3_HUMAN (see all proteins) (see all similar genes):
    C14orf23    EEF1E1    FLJ00047    C12orf76    ZNF799    GALK2
    DYNC2LI1    TUBA1C    BIRC2    DPP9    NLN    RBP7
    RQCD1    TNNT1    PFKFB3    COQ5    ZNF114    ILP3

    BIRC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BIRC3
    PGOHUM00000257921


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BIRC3 (see all 534)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159076681,2
    --102186188(+) ATTTAC/TGATAT 2 -- us2k10--------
    rs1922220961,2
    --102186189(+) TTTACA/GATATT 2 -- us2k10--------
    rs107135811,2
    C,F--102186309(+) CCAGGG/-CTGGA 2 -- us2k13Minor allele frequency- -:0.33NA 6
    rs1415120661,2
    --102186414(+) GCGTGC/TACCAC 2 -- us2k10--------
    rs178793171,2
    C,F--102186511(+) CCACCC/AACCTT 2 -- us2k11Minor allele frequency- A:0.01NS 178
    rs178860141,2
    C,F--102186564(+) CTGGTC/GAAAGA 2 -- us2k14Minor allele frequency- G:0.07NS WA CSA 300
    rs1384920061,2
    --102186780(+) GACCTA/GATAAT 2 -- us2k10--------
    rs1828779611,2
    --102186845(+) TACATG/TTAAAA 2 -- us2k10--------
    rs1877271971,2
    --102187117(+) AATACA/GCTTAG 2 -- us2k10--------
    rs1427331821,2
    --102187155(+) TTCAGC/TTGCTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BIRC3 (102188194 - 102210134 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BIRC3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIRC3
    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601721    OMIM disorders: --

    UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
  • Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue
    (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of
    cytogenetically abnormal low-grade MALT lymphoma

  • Selected diseases for BIRC3 (see all 69):    About MalaCards
    malt lymphoma    chronic neutrophilic leukemia    waldenstrom macroglobulinemia    macroglobulinemia
    marginal zone b-cell lymphoma    edwards syndrome    carotid stenosis    splenic marginal zone lymphoma
    b-cell lymphomas    patent ductus arteriosus    pleomorphic adenoma    malignant pleural mesothelioma
    cryoglobulinemia    adenoid cystic carcinoma    toxoplasmosis    burkitt's lymphoma
    adenoiditis    testicular germ cell tumor    acute promyelocytic leukemia    myeloma

    1 disease from the University of Copenhagen DISEASES database for BIRC3:
    Lymphoma

    BIRC3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for BIRC3 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malt lymphoma 75.1 17 10797525 (1), 11162514 (1), 19234489 (1), 11159207 (1) (see all 15)
    necrosis 61.1 22 10657935 (2), 11106668 (1), 17011514 (1), 16291753 (1) (see all 17)
    tumors 54.8 42 16983704 (3), 11484955 (3), 10657935 (2), 10815900 (2) (see all 26)
    lymphoma b-cell 50.5 8 11066071 (1), 16983704 (1), 14652825 (1)
    leukemia 44.2 6 16638183 (2), 16983704 (1)
    cancer 42 18 18570872 (3), 15856013 (2), 15265700 (1), 18992220 (1) (see all 13)
    lymphoma 39.8 4 16983704 (2), 10751367 (1)
    leukemia t-cell 39.1 1 19564891 (1)
    burkitt lymphoma 36.9 3 16983704 (1), 18503581 (1)
    muscular atrophy spinal 27.9 1 11397650 (1)

    Genetic Association Database (GAD): BIRC3
    Human Genome Epidemiology (HuGE) Navigator: BIRC3 (13 documents)

    Export disorders for BIRC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BIRC3 gene, integrated from 10 sources (see all 450):
    (articles sorted by number of sources associating them with BIRC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 3 Liston P.... Korneluk R.G. (Nature 1996)
    2. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)1, 2, 3 Rothe M.... Goeddel D.V. (Cell 1995)
    3. Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (PubMed id 11066071)1, 2, 9 Baens M.... Marynen P. (Genes Chromosomes Cancer 2000)
    4. IKKI/-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. (PubMed id 23453969)1, 2 Zhou A.Y....Hahn W.C. (Cell Rep 2013)
    5. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). (PubMed id 21931591)1, 2 Bertrand M.J.... Vandenabeele P. (PLoS ONE 2011)
    6. The USP19 deubiquitinase regulates the stability of c-IAP1 and c- IAP2. (PubMed id 21849505)1, 2 Mei Y.... Yang X. (J. Biol. Chem. 2011)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 330 HGNC: 591 AceView: BIRC3 Ensembl:ENSG00000023445 euGenes: HUgn330
    ECgene: BIRC3 Kegg: 330 H-InvDB: BIRC3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BIRC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/birc3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BIRC3 gene:
    Search GeneIP for patents involving BIRC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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