Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BIRC3 Gene

protein-coding   GIFtS: 67
GCID: GC11P102188

baculoviral IAP repeat containing 3

(Previous name: baculoviral IAP repeat-containing 3 )
(Previous symbol: API2)
 Explore 70 diseases affiliated with
BIRC3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BIRC3    

Aliases
for BIRC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Baculoviral IAP Repeat Containing 31 2     CIAP22
API21 2 3 5     Hiap-11
MIHC1 2 3     AIP12
RNF491 2 3     CIAP22
MALT21 2     HIAP12
Baculoviral IAP Repeat-Containing 31 2     Baculoviral IAP Repeat-Containing Protein 32
C-IAP23     Mammalian IAP Homolog C2
Apoptosis Inhibitor 22 3     TNFR2-TRAF Signaling Complex Protein2
Inhibitor Of Apoptosis Protein 12 3     C-IAP23
IAP-12 3     EC 6.3.2.-3
IAP Homolog C2 3     IAP13
RING Finger Protein 492 3     HIAP-11
TNFR2-TRAF-Signaling Complex Protein 12 3     HIAP12
HAIP12 5     

External Ids:    HGNC: 5911   Entrez Gene: 3302   Ensembl: ENSG000000234457   OMIM: 6017215   UniProtKB: Q134893   

Export aliases for BIRC3 gene to outside databases

Previous GC identifers: GC11P104381 GC11P103545 GC11P102222 GC11P101725 GC11P101693 GC11P098114


Summaries
for BIRC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BIRC3:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor
receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The
encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure
to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain.
Transcript variants encoding the same isoform have been identified. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory
signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis.
Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical
NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and
suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3
ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as
an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors
(NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects
cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill
cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating
RIPK1 and CASP8

Gene Wiki entry for BIRC3 (Baculoviral IAP repeat-containing protein 3)


Genomic Views
for BIRC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BIRC3 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BIRC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BIRC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22

BIRC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P102188:  view genomic region     (about GC identifiers)

Start:
 102,188,194 bp from pter      End:
 102,210,134 bp from pter
Size:
 21,941 bases      Orientation:
 plus strand

Proteins
for BIRC3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 3  
Size: 604 amino acids; 68372 Da
Subunit: Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR
motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex,
which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and
USP19
Subcellular location: Cytoplasm. Nucleus
5 PDB 3D structures from and Proteopedia for BIRC3:
2UVL (3D)        3EB5 (3D)        3EB6 (3D)        3M0A (3D)        3M0D (3D)    
Secondary accessions: Q16628 Q9HC27 Q9UP46

Explore the universe of human proteins at neXtProt for BIRC3: NX_Q13489

Post-translational modifications:

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13489

    • BIRC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001156.1  NP_892007.1  

    ENSEMBL proteins: 
     ENSP00000263464   ENSP00000432907   ENSP00000436855   ENSP00000431718  
    Reactome Protein details: Q13489
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BIRC3 (cIAP-2/HIAP-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): BIRC3
    OriGene Protein Over-expression Lysate (see all 2): BIRC3
    OriGene Custom Protein Services for BIRC3 
    GenScript Custom Purified and Recombinant Proteins Services for BIRC3
    Novus Biologicals BIRC3 Proteins
    Novus Biologicals BIRC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BIRC3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15665297
    GO:0005737cytoplasm IDA15665297


    BIRC3 for ontologies           About GeneDecksing



    BIRC3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BIRC3
    R&D Systems Antibodies for BIRC3 (cIAP-2/HIAP-1)
    Cell Signaling Technology (CST) Antibodies for BIRC3  (cIAP2)
    OriGene Antibodies (see all 9): BIRC3
    OriGene Custom Antibody Services for BIRC3 
    GenScript Custom Superior Antibodies Services for BIRC3
    Novus Biologicals BIRC3 Antibodies
    Abcam antibodies for BIRC3 
    Uscn Antibodies for BIRC3
    ThermoFisher Antibody for BIRC3

    Assay Products for BIRC3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for BIRC3 (cIAP-2/HIAP-1)
    GenScript Custom Assay Services for BIRC3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BIRC3

    Protein Domains /
    Families
    for BIRC3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BIRC3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001841 Znf_RING
     IPR001370 BIR
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q13489

    ProtoNet protein and cluster: Q13489

    3 Blocks protein families:
    IPB001315 CARD interaction domain
    IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
    Similarity: Belongs to the IAP family
    Similarity: Contains 3 BIR repeats
    Similarity: Contains 1 CARD domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for BIRC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
    Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory
    signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis.
    Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical
    NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and
    suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3
    ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as
    an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors
    (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects
    cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill
    cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating
    RIPK1 and CASP8
    Enzyme regulation: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target BIRC3:
    hsa-mir-34a (MIRT000071)

    OriGene 3'-UTR Clone (see all 2): BIRC3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIRC3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BIRC3:
    hsa-miR-369-3p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: BIRC3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIRC3 (see all 7)
    OriGene shRNA RFP: BIRC3
    OriGene siRNA: BIRC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BIRC3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BIRC3 (NM_182962)
    Sino Biological Human cDNA Clone for BIRC3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BIRC3
    Search LifeMap BioReagents cell lines for BIRC3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA16395405
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    BIRC3 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for BIRC3:
     Decreased Wnt reporter activit  Decreased cilium length after   Decreased viability after Chla  Increased cell death HMECs cel 
     Synthetic lethal with paclitax 

    Animal Models:
         Mouse knock-outs for BIRC3: Birc3tm1.1Rbr Birc3tm1Rgk
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Birc3):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  normal 

    BIRC3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BIRC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TWEAK Pathway
    8/11 pathways (see all 11)
    		TWEAK Pathway1.00
    		TNF Signaling0.40
    		DR3 Signaling0.87
    		Apoptotic Pathways Triggered By HIV10.37
    		TNFR1 Pathway0.53
    		Apoptosis through Death Receptors0.32
    		HIV-1 Nef- Negative effector of Fas and TNF-alpha0.42
    		TWEAK Signaling Pathway0.31
    2TRAF6 Mediated Induction of proinflammatory cytokines
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    		Activated TLR4 signalling0.63
    		MyD88-independent cascade 0.72
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		Toll Like Receptor 3 (TLR3) Cascade0.72
    		Toll-Like Receptors Cascades0.53
    3Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways1.00
    		NOD-like receptor signaling pathway0.36
    		NOD1/2 Signaling Pathway0.69
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Apoptosis Modulation and Signaling
    		Apoptosis Modulation and Signaling1.00
    		Apoptosis0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for BIRC3
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    1 R&D Systems Pathway for BIRC3
        Apoptosis Signaling Pathways

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BIRC3 (see all 12)
        Caspase Cascade
    TWEAK Pathway
    TRAF Pathway
    Molecular Mechanisms of Cancer
    TNFR2 Pathway

    1 Cell Signaling Technology (CST) Pathway for BIRC3
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for BIRC3
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival TNFR1 signaling pathway

    5/12 BioSystems Pathways for BIRC3 (see all 12) 
        Apoptosis
    Apoptosis Modulation and Signaling
    Focal Adhesion
    TWEAK Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    5/11        Reactome Pathways for BIRC3 (see all 11)
        IKK complex recruitment mediated by RIP1
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    MyD88-independent cascade


    5/7         Kegg Pathways  (Kegg details for BIRC3) (see all 7):
        Ubiquitin mediated proteolysis
    Apoptosis
    Focal adhesion
    NOD-like receptor signaling pathway
    Toxoplasmosis


    BIRC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIRC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for BIRC3 (Q134891, 3 ENSP000002634644) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5721, 3, ENSP000002162744EBI-517709,EBI-358587 I2D: score=1 STRING: ENSP00000216274
    TRAF2Q129331, 3, ENSP000002476684EBI-517709,EBI-1046651 I2D: score=9 STRING: ENSP00000247668
    DIABLOQ9NR281, 3, ENSP000002671694EBI-517709,EBI-517508 I2D: score=4 STRING: ENSP00000267169
    RIPK2O433531, 3, ENSP000002207514EBI-517709,EBI-358522 I2D: score=2 STRING: ENSP00000220751
    RIPK1Q135461, 3, ENSP000002598084EBI-517709,EBI-358507 I2D: score=2 STRING: ENSP00000259808
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007166cell surface receptor signaling pathway TAS8548810
    GO:0034121regulation of toll-like receptor signaling pathway TAS--
    GO:0038061NIK/NF-kappaB cascade TAS--
    GO:0039535regulation of RIG-I signaling pathway TAS--


    BIRC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BIRC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BIRC3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BIRC3
    10/33 Novoseek chemical compound relationships for BIRC3 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap2 95.4 64 17972100 (7), 20385093 (7), 16115895 (4), 16144937 (4) (see all 16)
    ciap1 93.7 38 15265700 (8), 20097753 (4), 18570872 (3), 17972100 (2) (see all 12)
    pdtc 49.7 5 12269771 (2), 14527959 (1)
    curcumin 44.5 5 16243823 (1), 17640567 (1), 16219905 (1), 15911101 (1) (see all 5)
    ly294002 43.8 2 14762343 (1), 19051078 (1)
    mg 132 41.9 1 14527959 (1)
    parthenolide 41.6 1 11588049 (1)
    triptolide 40.8 2 15972136 (1), 10224110 (1)
    etoposide 40.2 3 15050749 (1), 12243753 (1), 9384571 (1)
    doxorubicin 39.9 8 12926068 (2), 17311258 (1), 18434593 (1), 19746155 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about BIRC3 

    Transcripts
    for BIRC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BIRC3 gene (2 alternative transcripts): 
    NM_001165.4  NM_182962.2  

    Unigene Cluster for BIRC3:

    Baculoviral IAP repeat containing 3
    Hs.127799  [show with all ESTs]
    Unigene Representative Sequence: NM_001165
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526421 ENST00000263464(uc001pgx.3) ENST00000528940 ENST00000532808
    ENST00000532609 ENST00000527309 ENST00000527336

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): BIRC3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIRC3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BIRC3:
    hsa-miR-369-3p hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: BIRC3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIRC3 (see all 7)
    OriGene shRNA RFP: BIRC3
    OriGene siRNA: BIRC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BIRC3 (NM_182962)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIRC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC3

    Additional cDNA sequence: 

    AF070674.1 BC027485.2 BC037420.1 L43346.1 L49432.1 U45878.1 

    5 DOTS entries:

    DT.442857  DT.100813069  DT.92421251  DT.95177781  DT.100690941 

    24/228 AceView cDNA sequences (see all 228):

    AW139145 BU663067 BU685791 AA261801 AI767171 AI950126 AI880582 AA761368 
    AI823946 AI354462 NM_001165 BU608931 AI797582 AV716229 AA252610 BM476485 
    AA534507 BU662287 AI417860 BX475964 AW590487 BU665537 BM956105 AI880555 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                -     -     -                       -                                                   
    SP2:                                                                    -                                                   
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for BIRC3

    Expression
    for BIRC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BIRC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTTTTTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BIRC3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BIRC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BIRC3

    SOURCE GeneReport for Unigene cluster: Hs.127799

    UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
    Tissue specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid
    tissues, including spleen, thymus and peripheral blood lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including BIRC3 (see all 13): 
              NFKB Signaling Targets in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIRC3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC3

    Orthologs
    for BIRC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BIRC3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q9IA70_CHICK6
    		 baculoviral IAP repeat-containing 2
    		 70(a)
    		 1 → many
    		 1(186919506-186929678)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 65(a)
    		 1 → many
    		 3(192311974-192322685)
    zebrafish
    (Danio rerio)    		 Actinopterygii birc26
    		 baculoviral IAP repeat-containing 2
    		 51(a)
    		 1 → many
    		 21(21948887-21966212)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Iap23
    th1    		 anti-apoptosis apoptosis inhibitor3
    thread1    		 28(a)3
    43.3(n)1
    35.18(a)1    		   2 52D23
    397531  NM_168645.11  NP_730098.11 


    ENSEMBL Gene Tree for BIRC3 (if available)
    TreeFam Gene Tree for BIRC3 (if available) 

    Paralogs
    for BIRC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BIRC3 gene
    BIRC72  BIRC22  XIAP2  BIRC82  
    18 SIMAP similar genes for BIRC3 using alignment to 4 protein entries:     BIRC3_HUMAN (see all proteins):
    C14orf23    EEF1E1    FLJ00047    C12orf76    GALK2    DYNC2LI1
    TUBA1C    NLN    BIRC2    RQCD1    PFKFB3    COQ5
    BIRC7    ILP3    LOC100996300    IDNK    BIRC8    XIAP

    BIRC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BIRC3
    PGOHUM00000257921


    Genomic Variants
    for BIRC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/438 NCBI SNPs in BIRC3 are shown (see all 438)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1159076681,2
    		--102186188(+) ATTTAC/TGATAT 2 -- us2k10--------
    rs1922220961,2
    		--102186189(+) TTTACA/GATATT 2 -- us2k10--------
    rs107135811,2
    		C,F,--102186309(+) CCAGGG/-CTGGA 2 -- us2k13Minor allele frequency- -:0.33NA 6
    rs1415120661,2
    		--102186414(+) GCGTGC/TACCAC 2 -- us2k10--------
    rs178793171,2
    		C,--102186511(+) CCACCC/AACCTT 2 -- us2k11Minor allele frequency- A:0.01NS 178
    rs178860141,2
    		C,F,--102186564(+) CTGGTC/GAAAGA 2 -- us2k14Minor allele frequency- G:0.07NS WA CSA 300
    rs1384920061,2
    		--102186780(+) GACCTA/GATAAT 2 -- us2k10--------
    rs1828779611,2
    		--102186845(+) TACATG/TTAAAA 2 -- us2k10--------
    rs1877271971,2
    		--102187117(+) AATACA/GCTTAG 2 -- us2k10--------
    rs1427331821,2
    		--102187155(+) TTCAGC/TTGCTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BIRC3 (102188194 - 102210134 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BIRC3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC3
    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC3

    Disorders / Diseases
    for BIRC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BIRC3 for disorders           About GeneDecksing

    OMIM gene information: 601721    OMIM disorders: --

    UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
  • Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue
    • (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of
    cytogenetically abnormal low-grade MALT lymphoma

    20/70 diseases for BIRC3 (see all 70):    About MalaCards
    marginal zone b-cell lymphoma    splenic marginal zone lymphoma    diffuse large b-cell lymphoma    b-cell lymphomas
    patent ductus arteriosus    non-small cell lung carcinoma    anaplastic large cell lymphoma    testicular germ cell tumor
    malignant pleural mesothelioma    malt lymphoma    non-hodgkin lymphoma    chronic neutrophilic leukemia
    germ cell tumor    muscular atrophy    carotid stenosis    burkitt's lymphoma
    adenoid cystic carcinoma    edwards syndrome    acute promyelocytic leukemia    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for BIRC3:
    Lymphoma

    10/38 Novoseek disease relationships for BIRC3 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malt lymphoma 75.1 17 10797525 (1), 11162514 (1), 19234489 (1), 11159207 (1) (see all 15)
    necrosis 61.1 22 10657935 (2), 11106668 (1), 17011514 (1), 16291753 (1) (see all 17)
    tumors 54.8 42 16983704 (3), 11484955 (3), 10657935 (2), 10815900 (2) (see all 26)
    lymphoma b-cell 50.5 8 11066071 (1), 16983704 (1), 14652825 (1)
    leukemia 44.2 6 16638183 (2), 16983704 (1)
    cancer 42 18 18570872 (3), 15856013 (2), 15265700 (1), 18992220 (1) (see all 13)
    lymphoma 39.8 4 16983704 (2), 10751367 (1)
    leukemia t-cell 39.1 1 19564891 (1)
    burkitt lymphoma 36.9 3 16983704 (1), 18503581 (1)
    muscular atrophy spinal 27.9 1 11397650 (1)

    Human Genome Epidemiology (HuGE) Navigator: BIRC3 (13 documents)

    Export disorders for BIRC3 gene to outside databases

    Publications
    for BIRC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BIRC3 gene, integrated from 9 sources (see all 431):
    (articles sorted by number of sources associating them with BIRC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 3 Liston P.... Korneluk R.G. (1996)
    2. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)1, 2, 3 Rothe M.... Goeddel D.V. (1995)
    3. Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (PubMed id 11066071)1, 2, 9 Baens M.... Marynen P. (2000)
    4. cIAP1/2 are direct E3 ligases conjugating diverse typ es of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) . (PubMed id 21931591)1, 2 Bertrand M.J....Vandenabeele P. (2011)
    5. The USP19 deubiquitinase regulates the stability of c -IAP1 and c-IAP2. (PubMed id 21849505)1, 2 Mei Y....Yang X. (2011)
    6. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PubMed id 15665297)1, 2 Samuel T....Reed J.C. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)1, 2 Horrevoets A.J.G.... Pannekoek H. (1999)
    9. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. (PubMed id 8643514)1, 2 Uren A.G.... Vaux D.L. (1996)
    10. Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. (PubMed id 12393423)1, 9 Hasegawa T....Kitagawa S. (2003)

    External Searches for BIRC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BIRC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 330 HGNC: 591 AceView: BIRC3 Ensembl:ENSG00000023445 euGenes: HUgn330
    ECgene: BIRC3 Kegg: 330 H-InvDB: BIRC3

    Other Databases showing BIRC3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BIRC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BIRC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/birc3/

    Intellectual Property
    for BIRC3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BIRC3 gene:
    Search GeneIP for patents involving BIRC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BIRC3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BIRC3
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for BIRC3 (cIAP-2/HIAP-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for BIRC3 (cIAP-2/HIAP-1)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for BIRC3 (cIAP-2/HIAP-1)  
     OriGene Antibodies for BIRC3   OriGene shRNA RFP for BIRC3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIRC3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC3  
     OriGene Protein Over-expression Lysate for BIRC3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BIRC3   OriGene 3'-UTR Clone for BIRC3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for BIRC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BIRC3   OriGene Custom Protein Services for BIRC3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BIRC3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC3
     GenScript Custom Purified and Recombinant Proteins Services for BIRC3 GenScript cDNA clones with any tag delivered in your preferred vector for BIRC3
     GenScript Custom Assay Services for BIRC3 GenScript Custom Superior Antibodies Services for BIRC3
     GenScript Custom overexpressing Cell Line Services for BIRC3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for BIRC3  (cIAP2)

     Regulatory tfbs in BIRC3 promoter
     Search Chromatin IP Primers for BIRC3
     RT2 qPCR Primer Assay in human, mouse, rat BIRC3
     GNC Network for BIRC3
     SABiosciences PCR Arrays including human, mouse, rat BIRC3
     Search Tocris compounds for BIRC3
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for BIRC3
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BIRC3 antibodies
     BIRC3 proteins
     BIRC3 lysates
     Antibodies for BIRC3
     See all of Abcam's Antibodies, Kits and Proteins for BIRC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     BIRC3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BIRC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC3
     SwitchGear 3'UTR luciferase reporter plasmids for BIRC3
     SwitchGear Promoter luciferase reporter plasmids for BIRC3
     ThermoFisher Antibody for BIRC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      BIRC3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4