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BIRC3 Gene

protein-coding GIFtS: 65

GC11P101693

baculoviral IAP repeat-containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: API2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AIP1 ^²
API2 ^², ³
C-IAP2 ^³
CIAP2 ^²
HAIP1 ^²
HIAP-1 ^³
HIAP1 ^², ³
IAP1 ^³
MALT2 ^¹, ²
MIHC ^¹, ², ³
RNF49 ^¹, ², ³
cIAP2 ^¹
hiap-1 ^¹

Descriptions
Apoptosis inhibitor 2 ^², ³
IAP homolog C ^³
Inhibitor of apoptosis protein 1 ^², ³
RING finger protein 49 ^³
TNFR2-TRAF signaling complex protein ^²
TNFR2-TRAF-signaling complex protein 1 ^³
baculoviral IAP repeat-containing 3 ^²
baculoviral IAP repeat-containing protein 3 ^²
mammalian IAP homolog C ^²

External Ids
HGNC: 591¹
Entrez Gene: 330²
UniProtKB: Q13489³
Ensembl: ENSG00000023445⁷

Search outside databases for aliases for BIRC3 gene

Previous GC identifers: GC11P104381 GC11P103545 GC11P102222 GC11P101725

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BIRC3:

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by

binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by

interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced

by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent

inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains

and a ring finger domain. Transcript variants encoding the same isoform have been identified.

[provided by RefSeq]

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated

factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the

tumor necrosis factor receptor 2 (TNFR2)

Gene Wiki entry for BIRC3 (Baculoviral_IAP_repeat-containing_protein_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BIRC3 gene

Entrez Gene cytogenetic band: 11q22 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22

BIRC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P101693: (about GC identifiers)

Start:	101,693,404 bp from pter
End:	101,713,675 bp from pter
Size:	20,272 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 3

Size: 604 amino acids; 68372 Da

Subunit: Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor

activity

Subcellular location: Cytoplasm (Potential)

PDB structures from and Proteopedia :

2UVL (3D)

3EB5 (3D)

3EB6 (3D)

Secondary accessions: Q16628 Q9HC27 Q9UP46

REFSEQ proteins (2 alternative transcripts):

NP_001156.1 NP_892007.1

ENSEMBL proteins:

ENSP00000376897 ENSP00000263464

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BIRC3 (cIAP-2/HIAP-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (cIAP2)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: BIRC3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	16123224
GO:0005737	cytoplasm	IDA	16123224

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Antibodies for BIRC3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BIRC3
	Sigma-Aldrich Antibodies for BIRC3
	R&D Systems Antibodies for BIRC3 (cIAP-2/HIAP-1)
	Cell Signaling Technology (CST) Antibodies for BIRC3 (c-IAP2)
	Antibodies from Abcam (cIAP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BIRC3)
	Novus Biologicals Antibodies for BIRC3

Assays for BIRC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13489

ProtoNet protein and cluster: Q13489

3 Blocks protein families:

IPB001315 CARD interaction domain

IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Similarity: Belongs to the IAP family

Similarity: Contains 3 BIR repeats

Similarity: Contains 1 CARD domain

Similarity: Contains 1 RING-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BIRC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BIRC3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182962

Applied Biosystems Silencer® siRNAs for BIRC3

Sigma-Aldrich siRNA and siRNA Panels for BIRC3

Sigma-Aldrich shRNA Panels and shRNA for BIRC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BIRC3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001165
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001165
untagged cDNA clones in CMV expression vector (see all 2): NM_001165

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001165

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated

factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the

tumor necrosis factor receptor 2 (TNFR2)

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Birc3):

hematopoietic system

immune system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	16395405
GO:0005515	protein binding	IPI	16123224 16395405
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for BIRC3 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Protein Ubiquitination Pathway
Death Receptor Signaling
Molecular Mechanisms of Cancer
Induction of Apoptosis by HIV1
Amyotrophic Lateral Sclerosis Signaling

GeneDecks BIRC3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BIRC3

5/76 Interacting proteins for BIRC3 (ENSP00000263464³ Q13489¹) via UniProtKB, MINT, and/or STRING (see all 76 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DIABLO	Q9NR28¹	STRING (score=.999) EBI-517709, EBI-517508
TRAF2	Q12933¹	STRING (score=.986) EBI-517709, EBI-355744
TRAF1	ENSP00000362994³	STRING (score=.999)
TNFRSF1A	ENSP00000162749³	STRING (score=.998)
CASP9	ENSP00000330237³	STRING (score=.996)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006916	anti-apoptosis	TAS	8552191
GO:0007166	cell surface receptor linked signal transduction	TAS	8548810
GO:0042981	regulation of apoptosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BIRC3
10 Novoseek chemical compound relationships for BIRC3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ciap2	95.06	49	17972100 (7), 16115895 (4), 17989734 (4), 16144937 (4) (see all 13)
ciap1	92.23	26	15265700 (8), 18570872 (3), 17972100 (2), 16892011 (1) (see all 9)
sp 600125	43.57	1	17133355 (1)
phosphatidylinositol	26.11	1	16154993 (1)
oligonucleotide	6.77	1	17253596 (1)
lipid	3.60	2	17255535 (2)
calcium	1.37	1	16154993 (1)
oxygen	0.00	1	15486995 (1)
vitamin-e	0.00	2	15566391 (2)
tyrosine	0.00	1	11588049 (1)

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2 PharmGKB drug compound relationships for BIRC3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
dexamethasone	FA	12239098
glucocorticoids	FA	12239098

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BIRC3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BIRC3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182962

Sigma-Aldrich siRNA and siRNA Panels for BIRC3

Sigma-Aldrich shRNA Panels and shRNA for BIRC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001165 NM_182962

REFSEQ mRNAs for BIRC3 gene (2 alternative transcripts):

NM_001165.3 NM_182962.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001165 NM_182962

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001165
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001165
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001165

Additional cDNA sequence:

AF070674.1 BC027485.2 BC037420.1 L43346.1 L49432.1 U45878.1

6 DOTS entries:

DT.442857 DT.100813069 DT.92421251 DT.95177781 DT.92425948 DT.100690941

24/228 AceView cDNA sequences (see all 228 ):

BU685791 AW591294 AI767171 AA252610 AA962737 AI678800 AV716229 AI581499

BU663067 AA761368 BU663663 AI823946 AI354462 AA261801 BU665522 AI880555

AW590487 BF339660 AI797582 AI950016 AI950126 AA534507 BM476485 AI635855

highest scoring ESTs for BIRC3:

U45878 AA243387 AA252610 AA314209 AA534507 AA582034 AA582044 AA808391 AA828467 AF070674

Unigene Cluster for BIRC3:

Baculoviral IAP repeat-containing 3

Hs.127799 [show with all ESTs]

Unigene Representative Sequence: NM_001165

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC3

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:											-		-		-								-
SP2:																							-
SP3:
SP4:
SP5:							-

About this scheme

ECgene alternative splicing isoforms for BIRC3

2 Ensembl transcripts including schematic representations:

ENST00000393201 ENST00000263464

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BIRC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BIRC3

¹ / ² / ³

5 probe-sets matching BIRC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
91017_at²^{, 3}	U95-E	1	1.00	1.00	0.36	0.80	U54711	0.80	0.88	0.84	1
1717_s_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.98	U45878	1.00	0.90	0.95	1
63769_at²^{, 3}	U95-C	1	0.44	1.00	0.93	1.25	AI749656	0.80	0.88	0.84	1
210538_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U37546	0.60	0.83	0.73	1
210538_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BIRC3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGTTTTTAT

SOURCE GeneReport for Unigene cluster: Hs.127799
Expression variation in blood from EXPOLDB for BIRC3
UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489
Tissue specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly
seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BIRC3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BIRC3¹	--	baculoviral IAP repeat-containing 3	76.38(n) 74.5(a)	489433 XM_546551.2 XP_546551.2
chimpanzee (Pan troglodytes)	BIRC3¹	--	baculoviral IAP repeat-containing 3	99.12(n) 99.01(a)	451507 XM_001151914.1 XP_001151914.1
cow (Bos taurus)	BIRC3¹	--	baculoviral IAP repeat-containing 3	88.69(n) 85.76(a)	514386 NM_001035293.1 NP_001030370.1
rat (Rattus norvegicus)	Birc3¹	--	baculoviral IAP repeat-containing 3	76.91(n) 74.25(a)	78971 NM_023987.2 NP_076477.2
mouse (Mus musculus)	Birc3^{1, 5}	9⁵	baculoviral IAP repeat-containing 3^{1, 5}	77.11(n)¹ 74.33(a)¹	11796¹ NM_007464.2¹ NP_031490.1¹ AI606357⁵ AK154721⁵ (see all 14)

About this table Species with no ortholog for BIRC3

ENSEMBL Gene Tree for BIRC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for BIRC3 gene

BIRC7² ENSG00000163098² XIAP² BIRC2² BIRC8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/170 NCBI SNPs in BIRC3 are shown (see all 170 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 111)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3460^1,2	A,C,F,H,O	101713600(+)	`TGAATG/CACATT`	2	--	ut3¹		33	NS MN EU EA WA NA CSAM	4164
	rs11225216^1,2	A,C,F,H	101713264(+)	`AAGAGG/ATAGCA`	2	--	ut3¹ trp³		5	EU EA WA NS	598
	rs1055088^1,2	A,C,F,H	101713061(+)	`ACATCA/GTCTAA`	2	--	ut3¹		10	MN EA NA NS EU WA	996
	rs2276113^1,2	C,F,H,O	101701229(+)	`CTTTAA/GAACAT`	2	K/R	mis¹		25	EA NA NS MN CSAM EU WA	3538
	rs3740932^1,2	C,F,H	101713625(+)	`TTTTTA/GTAAAG`	2	--	ut3¹		20	EU EA WA NA NS MN CSAM	3074
	rs17097648^1,2	C,F,H	101698687(+)	`TGTGAG/CATCCA`	2	--	ut5¹ int¹ ese³		8	NA NS EU EA WA	738
	rs11225217^1,2	C,F,H	101713846(+)	`TATTAT/GGGAAT`	2	--	ng3¹		8	NA NS EU EA WA	740
--	rs17882391^1,2	C,F	101700334(+)	`ATAATA/GAAAAA`	2	--	int¹ ut5¹		7	NS	836
	rs17878442^1,2	C,F	101697784(+)	`TTTACA/CAAGGA`	2	--	ut5¹ ese³ trp³		7	NS	838
	rs17885946^1,2	F	101699902(+)	`CTCCTT/CTGAGT`	2	--	ut5¹ int¹ trp³		1	NS	174

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HapMap Linkage Disequilibrium images for BIRC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601721

UniProtKB/Swiss-Prot: BIRC3_HUMAN, Q13489

A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated

lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is

found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma

10/36 Novoseek disease relationships for BIRC3 gene (see all 36 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
malt lymphoma	76.61	17	10797525 (1), 11162514 (1), 19234489 (1), 11159207 (1) (see all 15)
necrosis	61.07	20	10657935 (2), 11106668 (1), 17011514 (1), 16291753 (1) (see all 15)
tumors	53.49	39	16983704 (3), 11484955 (3), 10657935 (2), 10815900 (2) (see all 24)
lymphoma b-cell	53.38	8	11066071 (1), 16983704 (1), 14652825 (1)
leukemia	41.18	6	16638183 (2), 16983704 (1)
lymphoma	41.14	4	16983704 (2), 10751367 (1)
burkitt lymphoma	39.47	3	16983704 (1), 18503581 (1)
cancer	36.66	17	18570872 (3), 15856013 (2), 15265700 (1), 18992220 (1) (see all 12)
muscular atrophy spinal	30.84	1	11397650 (1)
colon cancer	29.53	8	14527959 (4), 15078890 (3)

About this table

Human Genome Epidemiology Navigator: BIRC3 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/326 PubMed articles for BIRC3 gene (see all 326 ):

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)^{2, 3, 4} Liston P.... Korneluk R.G. (1996)
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)^{2, 3, 4} Rothe M....Goeddel D.V. (1995)
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (PubMed id 11066071)^{1, 3, 4} Baens M.... Marynen P. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)^{3, 4} Horrevoets A.J.G.... Pannekoek H. (1999)
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. (PubMed id 8643514)^{3, 4} Uren A.G.... Vaux D.L. (1996)
Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. (PubMed id 12393423)^{1, 3} Hasegawa T....Kitagawa S. (2003)
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. (PubMed id 14527959)^{1, 3} Wang Q....Evers B.M. (2003)
Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis. (PubMed id 15856013)^{1, 3} Yuan H....Liu X. (2005)
Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest. (PubMed id 16813569)^{1, 3} Jin H.S. and Lee T.H. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 330	HGNC: 591	AceView: BIRC3	Ensembl:ENSG00000023445	euGenes: HUgn330
ECgene: BIRC3	H-InvDB: BIRC3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BIRC3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/birc3/

Licensable Technologies for BIRC3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for BIRC3:

TaqMan ® Gene Expression Assays

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Antibodies & Assays for BIRC3 (c-IAP2)

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Antibodies for BIRC3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BIRC3 Gene at Home site.
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BIRC3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for BIRC3

Summaries
for BIRC3

Genomic Location
for BIRC3

Proteins
for BIRC3

Protein Domains/
Families
for BIRC3

Gene Function
for BIRC3

Pathways & Interactions
for BIRC3

Drugs & Compounds
for BIRC3

Transcripts
for BIRC3

Expression
for BIRC3

Orthologs
for BIRC3

Paralogs
for BIRC3

SNPs/Variants
for BIRC3

Disorders & Mutations
for BIRC3

Medical News
for BIRC3

Publications
for BIRC3

Search for BIRC3

Genome Databases showing BIRC3

Other Databases showing BIRC3

Specialized Databases showing BIRC3

Licensable Technologies
for BIRC3

Services
for BIRC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BIRC3 (Gene Symbol)
AIP1
API2
C-IAP2
CIAP2
HAIP1
HIAP-1
HIAP1
IAP1
MALT2
MIHC
RNF49
cIAP2
hiap-1
Apoptosis inhibitor 2
IAP homolog C
Inhibitor of apoptosis protein 1
RING finger protein 49
TNFR2-TRAF signaling complex protein
TNFR2-TRAF-signaling complex protein 1
baculoviral IAP repeat-containing 3
baculoviral IAP repeat-containing protein 3
mammalian IAP homolog C

BIRC3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor BIRC3

Summariesfor BIRC3

Genomic Locationfor BIRC3

Proteinsfor BIRC3

Protein Domains/Familiesfor BIRC3

Gene Functionfor BIRC3

Pathways & Interactionsfor BIRC3

Drugs & Compoundsfor BIRC3

Transcriptsfor BIRC3

Expression for BIRC3

Orthologsfor BIRC3

Paralogsfor BIRC3

SNPs/Variantsfor BIRC3

Disorders & Mutationsfor BIRC3

Medical Newsfor BIRC3

Publicationsfor BIRC3

Search for BIRC3

Genome Databases showing BIRC3

Other Databases showing BIRC3

Specialized Databases showing BIRC3

Licensable Technologiesfor BIRC3

Servicesfor BIRC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BIRC3

Summaries
for BIRC3

Genomic Location
for BIRC3

Proteins
for BIRC3

Protein Domains/
Families
for BIRC3

Gene Function
for BIRC3

Pathways & Interactions
for BIRC3

Drugs & Compounds
for BIRC3

Transcripts
for BIRC3

Expression
for BIRC3

Orthologs
for BIRC3

Paralogs
for BIRC3

SNPs/Variants
for BIRC3

Disorders & Mutations
for BIRC3

Medical News
for BIRC3

Publications
for BIRC3

Licensable Technologies
for BIRC3

Services
for BIRC3