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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BIRC2 Gene

protein-coding   GIFtS: 68
GCID: GC11P102252

Baculoviral IAP Repeat Containing 2

(Previous name: baculoviral IAP repeat-containing 2)
(Previous symbol: API1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Baculoviral IAP Repeat Containing 21 2     TNFR2-TRAF-Signaling Complex Protein 22 3
API11 2 3 5     HIAP22 5
Baculoviral IAP Repeat-Containing 21 2     Hiap-22
Apoptosis Inhibitor 11 2     Baculoviral IAP Repeat-Containing Protein 22
NFR2-TRAF Signalling Complex Protein1 2     c-IAP12
Inhibitor Of Apoptosis Protein 22 3     cIAP12
IAP-22 3     C-IAP13
MIHB2 3     EC 6.3.2.-3
RNF482 3     IAP23
IAP Homolog B2 3     hIAP-23
RING Finger Protein 482 3     hIAP23

External Ids:    HGNC: 5901   Entrez Gene: 3292   Ensembl: ENSG000001103307   OMIM: 6017125   UniProtKB: Q134903   

Export aliases for BIRC2 gene to outside databases

Previous GC identifers: GC11P104413 GC11P103575 GC11P101757 GC11P101755 GC11P101723 GC11P098144


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BIRC2 Gene:
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor
necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like
proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer
of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for BIRC2 Gene: 
BIRC2 (baculoviral IAP repeat containing 2) is a protein-coding gene. Diseases associated with BIRC2 include malt lymphoma, and salivary gland cancer, and among its related super-pathways are DR3 Signaling and NOD1/2 Signaling Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and protein N-terminus binding. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion
and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both
canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator
of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8,
TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3
ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and
inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors
(TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition
receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex
that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses
ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1.
Plays a role in the modulation of the cell cycle

Gene Wiki entry for BIRC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BIRC2 gene promoter:
         TBP   AP-1   p53   SRF (504 AA)   ATF-2   Nkx2-5   HOXA5   TFIID   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BIRC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BIRC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22

BIRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P102252:  view genomic region     (about GC identifiers)

Start:
102,217,942 bp from pter      End:
102,249,401 bp from pter
Size:
31,460 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 2  
Size: 618 amino acids; 69900 Da
Subunit: Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.
Interacts with CASP9. Interacts (via BIR domains) with TRAF2. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4,
BIRC5/survivin and USP19
Subcellular location: Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic
pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with
the midbody in telophase cells, and found diffusely in the nucleus of interphase cells
6/12 PDB 3D structures from and Proteopedia for BIRC2 (see all 12):
1QBH (3D)        2L9M (3D)        3D9T (3D)        3D9U (3D)        3M1D (3D)        3MUP (3D)    
Secondary accessions: B4E026 Q16516 Q4TTG0
Alternative splicing: 2 isoforms:  Q13490-1   Q13490-2   

Explore the universe of human proteins at neXtProt for BIRC2: NX_Q13490

Explore proteomics data for BIRC2 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated and degraded by the proteasome in apoptotic cells
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13490

  • BIRC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BIRC2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001157.1  NP_001243092.1  NP_001243095.1  

    ENSEMBL proteins: 
     ENSP00000432410   ENSP00000431723   ENSP00000433851   ENSP00000227758   ENSP00000434979  
     ENSP00000436741   ENSP00000434708   ENSP00000434557  
    Reactome Protein details: Q13490
    Human Recombinant Protein Products for BIRC2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BIRC2 (cIAP-1/HIAP-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BIRC2
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for BIRC2 
    OriGene Custom Protein Services for BIRC2
    GenScript Custom Purified and Recombinant Proteins Services for BIRC2
    Novus Biologicals BIRC2 Proteins
    Novus Biologicals BIRC2 Lysate
    Sino Biological Recombinant Protein for BIRC2
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BIRC2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15665297
    GO:0005829cytosol TAS--
    GO:0009898internal side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--

    BIRC2 for ontologies           About GeneDecksing



    BIRC2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BIRC2
    R&D Systems Antibodies for BIRC2 (cIAP-1/HIAP-2)
    Cell Signaling Technology (CST) Antibodies for BIRC2 
    OriGene Antibodies for BIRC2
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    GenScript Custom Superior Antibodies Services for BIRC2
    Novus Biologicals BIRC2 Antibodies
    Abcam antibodies for BIRC2
    Cloud-Clone Corp. Antibodies for BIRC2 
    ThermoFisher Antibodies for BIRC2
    LSBio Antibodies in human, mouse, rat for BIRC2 

    Assay Products for BIRC2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BIRC2
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for BIRC2 (cIAP-1/HIAP-2)         (see all)
    GenScript Custom Assay Services for BIRC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BIRC2 
    Cloud-Clone Corp. CLIAs for BIRC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BIRC: Baculoviral IAP repeat containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR001370 BIR
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q13490

    ProtoNet protein and cluster: Q13490

    3 Blocks protein domains:
    IPB001315 CARD interaction domain
    IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
    Domain: The BIR domains mediate nuclear localization
    Domain: The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein
    ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and
    activation
    Similarity: Belongs to the IAP family
    Similarity: Contains 3 BIR repeats
    Similarity: Contains 1 CARD domain
    Similarity: Contains 1 RING-type zinc finger


    BIRC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC2_HUMAN, Q13490
    Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
    inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion
    and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both
    canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator
    of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
    proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8,
    TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3
    ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and
    inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors
    (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition
    receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex
    that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses
    ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1.
    Plays a role in the modulation of the cell cycle
    Enzyme regulation: The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING
    domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the
    E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability
    of BIRC2/c-IAP1 by preventing its ubiquitination

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IMP--
    GO:0004842ubiquitin-protein ligase activity IDA11907583
    GO:0005515protein binding IPI11084335
    GO:0008270zinc ion binding IDA19153467
    GO:0047485protein N-terminus binding IPI19153467
         
    BIRC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BIRC2:
     Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Birc2):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  normal 

    BIRC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BIRC2: Birc2tm1.1Rbr Birc2tm1Jda

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BIRC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BIRC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIRC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIRC2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIRC2:
    hsa-mir-204 (MIRT005820)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIRC2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BIRC2:
    hsa-miR-342-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidBIRC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BIRC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BIRC2
    Sirion Biotech Customized adenovirus for overexpression of BIRC2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BIRC2 (see all 7)
    OriGene ORF clones in mouse, rat for BIRC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIRC2 (NM_001166)
    Sino Biological Human cDNA Clone for BIRC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC2
    Sirion Biotech Customized lentivirus for stable overexpression of BIRC2 
                         Customized lentivirus expression plasmids for stable overexpression of BIRC2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BIRC2
    Search LifeMap BioReagents cell lines for BIRC2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BIRC2 About   (see all 36)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    Fas Signaling0.35
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    3Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    4Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    LT-BetaR Pathway0.46
    5Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for BIRC2
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    2 R&D Systems Pathways for BIRC2
        NOD-like Receptor Signaling Pathways
    Apoptosis Signaling Pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BIRC2 (see all 15)
        Caspase Cascade
    TWEAK Pathway
    LT-BetaR Pathway
    TRAF Pathway
    Mitochondrial Apoptosis

    1 Cell Signaling Technology (CST) Pathway for BIRC2
        Apoptosis and Autophagy

    5 GeneGo (Thomson Reuters) Pathways for BIRC2
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival TNFR1 signaling pathway

    5/10 BioSystems Pathways for BIRC2 (see all 10)
        Focal Adhesion
    Apoptosis
    Apoptosis Modulation and Signaling
    TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway

    1 Sino Biological Pathway for BIRC2 
        Death Receptor Signaling

    5/14        Reactome Pathways for BIRC2 (see all 14)
        IKK complex recruitment mediated by RIP1
    Apoptotic execution phase
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

    1 PharmGKB Pathway for BIRC2
        Busulfan Pathway, Pharmacodynamics

    5/10         Kegg Pathways  (Kegg details for BIRC2) (see all 10):
        NF-kappa B signaling pathway
    Ubiquitin mediated proteolysis
    Apoptosis
    Hippo signaling pathway
    Focal adhesion


    BIRC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIRC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/107 Interacting proteins for BIRC2 (Q134901, 2, 3 ENSP000002277584) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUPP149232, 3, ENSP000003111134MINT-66507 I2D: score=5 STRING: ENSP00000311113
    RIPK2O433531, 3, ENSP000002207514EBI-514538,EBI-358522 I2D: score=4 STRING: ENSP00000220751
    RIPK3Q9Y5721, 3, ENSP000002162744EBI-514538,EBI-298250 I2D: score=1 STRING: ENSP00000216274
    CASP7P552101, 3EBI-514538,EBI-523958 I2D: score=5 
    TNFP013753, ENSP000003986984I2D: score=4 STRING: ENSP00000398698
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA11907583
    GO:0001890placenta development IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-dependent IEA--

    BIRC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BIRC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BIRC2

    10/30 Novoseek inferred chemical compound relationships for BIRC2 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap1 97.1 153 15265700 (10), 19893574 (7), 20356846 (7), 15665297 (7) (see all 23)
    ciap2 92.4 20 18997792 (3), 17972100 (2), 15380346 (2), 19269012 (2) (see all 10)
    sp 600125 51.5 4 17133355 (1), 18343029 (1)
    curcumin 48.9 5 16243823 (1), 19372569 (1), 18386790 (1), 16219905 (1) (see all 5)
    etoposide 43.4 6 11071269 (2), 15050749 (1), 12243753 (1), 9384571 (1)
    doxorubicin 40.8 9 16618750 (3), 14666661 (2), 17521628 (2), 19351859 (1) (see all 5)
    cisplatin 38.4 9 16618750 (3), 11145600 (1), 20407239 (1), 11895917 (1) (see all 7)
    paclitaxel 38.3 4 16243823 (1), 16618750 (1), 19351859 (1), 14617792 (1)
    wortmannin 37.7 4 15995629 (2), 17074018 (1), 12888921 (1)
    ly294002 36.6 1 17229588 (1)

    Search CenterWatch for drugs/clinical trials and news about BIRC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BIRC2 gene (3 alternative transcripts): 
    NM_001166.4  NM_001256163.1  NM_001256166.1  

    Unigene Cluster for BIRC2:

    Baculoviral IAP repeat containing 2
    Hs.696238  [show with all ESTs]
    Unigene Representative Sequence: BC028578
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527808 ENST00000532832 ENST00000530675 ENST00000534646 ENST00000533742
    ENST00000227758(uc001pgy.3 uc010ruq.2) ENST00000532672 ENST00000531259
    ENST00000527465 ENST00000527910(uc010rur.2) ENST00000528344 ENST00000534130

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIRC2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BIRC2:
    hsa-miR-342-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidBIRC2 3' UTR sequence
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    Additional mRNA sequence: 

    AK225856.1 AK303197.1 AK313446.1 BC016174.1 BC028578.1 BX647978.1 L49431.1 U37547.1 
    U45879.1 

    13 DOTS entries:

    DT.99955512  DT.455872  DT.101966491  DT.91808576  DT.99969815  DT.120734536  DT.95121789  DT.97806829 
    DT.100679229  DT.100730532  DT.102830794  DT.92444769  DT.95299594 

    24/250 AceView cDNA sequences (see all 250):

    AA421225 AA773975 AW028956 AI188555 BG028431 AL601644 NM_001166 AI016580 
    BQ439248 BC016174 AU077055 BU902159 AW372983 AA706695 AA969704 AA504096 
    AA281679 N78871 BF509777 BQ884287 BM785364 AA935628 R83678 CB132520 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                         -                                             
    SP2:                                                        -                                             
    SP3:                                                                                                      
    SP4:              -     -                                                                                 
    SP5:                                                  -     -                                             


    ECgene alternative splicing isoforms for BIRC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BIRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTAGTCTG
    BIRC2 Expression
    About this image


    See BIRC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BIRC2

    SOURCE GeneReport for Unigene cluster: Hs.696238

    UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
    Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus,
    testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including BIRC2 (see all 9): 
              NFKB Signaling Targets in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BIRC2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Birc21 , 5 baculoviral IAP repeat-containing 21, 5 84.64(n)1
    84.75(a)1
      9 (2.46 cM)5
    117971  NM_007465.21  NP_031491.21 
     78182365 
    chicken
    (Gallus gallus)
    Aves BIRC21 baculoviral IAP repeat containing 2 73.43(n)
    72.99(a)
      374012  NM_001007822.1  NP_001007823.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    3(192311974-192323674)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145082 Xenopus laevis transcribed sequence with weak similarity more 75.78(n)    BJ059822.1 
    zebrafish
    (Danio rerio)
    Actinopterygii birc32 baculoviral IAP repeat-containing 3 75.27(n)   373107  AY247786.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Iap21 , 3 anti-apoptosis apoptosis inhibitor3
    Inhibitor of apoptosis 21
    29(a)3
    45.1(n)1
    36.97(a)1
      2 52D23
    367481  NM_057779.41  NP_477127.11 


    ENSEMBL Gene Tree for BIRC2 (if available)
    TreeFam Gene Tree for BIRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BIRC2 gene
    BIRC32  BIRC72  XIAP2  BIRC82  
    4 SIMAP similar genes for BIRC2 using alignment to 7 protein entries:     BIRC2_HUMAN (see all proteins):
    BIRC3    ILP3    BIRC7    XIAP

    BIRC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/780 SNPs in BIRC2 are shown (see all 780)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0250164
    ----see VAR_0250162 M V mis40--------
    rs1914759941,2
    --102216057(+) TTAGGA/GCGTTT 2 -- us2k10--------
    rs1496987931,2
    C--102216096(+) GGCTTC/TATTGT 2 -- us2k10--------
    rs351132671,2
    C,F--102216247(+) TTAAGA/CTTAAC 3 -- us2k15Minor allele frequency- C:0.00NS 186
    rs1454433801,2
    --102216309(+) CTGAAC/TTAACT 3 -- us2k10--------
    rs1488269241,2
    --102216324(+) GTAACA/GCTAGA 3 -- us2k10--------
    rs1469983661,2
    --102216364(+) GAGGTA/GCTATT 3 -- us2k10--------
    rs1168450461,2
    C,F--102216518(+) CTTGAG/TTTCAG 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1476543521,2
    --102216553(+) TTTTCC/TCACAT 3 -- us2k10--------
    rs1149285481,2
    C,F--102216664(+) TGGGAG/ACCATG 3 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for BIRC2 (102217942 - 102249401 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BIRC2: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601712    OMIM disorders: --

    20/59 diseases for BIRC2 (see all 59):    About MalaCards
    malt lymphoma    salivary gland cancer    pleomorphic adenoma    malignant pleural mesothelioma
    adenoid cystic carcinoma    patent ductus arteriosus    urethritis    thyroid cancer
    adenoiditis    burkitt's lymphoma    toxoplasmosis    cervical cancer
    anaplastic large cell lymphoma    spinal muscular atrophy    prostate cancer, progression of    myeloma
    muscular atrophy    cblc    lymphoblastic leukemia    ataxia telangiectasia

    1 disease from the University of Copenhagen DISEASES database for BIRC2:
    Cancer

    BIRC2 for disorders           About GeneDecksing

    10/31 Novoseek inferred disease relationships for BIRC2 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 62.2 20 20356846 (2), 8943045 (1), 11106668 (1), 15187025 (1) (see all 17)
    tumors 57 55 16983704 (3), 11484955 (3), 15187025 (2), 17154176 (2) (see all 32)
    cancer 45.9 26 18570872 (3), 18230607 (2), 18448338 (2), 19138149 (1) (see all 18)
    leukemia 45.1 1 16983704 (1)
    prostate cancer 31.4 6 15065090 (3), 19549337 (2), 11948968 (1)
    carcinoma squamous cell 31 7 15911110 (2), 18621506 (2), 11559525 (1), 12208731 (1)
    myeloma 29.6 2 16983704 (1)
    lymphoma b-cell 19.5 4 15187025 (1), 16983704 (1)
    burkitt lymphoma 16.9 1 16983704 (1)
    colorectal cancer 13.6 3 14708638 (2), 19578769 (1)

    Genetic Association Database (GAD): BIRC2
    Human Genome Epidemiology (HuGE) Navigator: BIRC2 (10 documents)

    Export disorders for BIRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BIRC2 gene, integrated from 9 sources (see all 423):
    (articles sorted by number of sources associating them with BIRC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 3 Liston P.... Korneluk R.G. (1996)
    2. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)1, 2, 3 Rothe M.... Goeddel D.V. (1995)
    3. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PubMed id 15665297)1, 2, 9 Samuel T....Reed J.C. (2005)
    4. The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. (PubMed id 19153467)1, 2, 9 Kulathila R....Price A. (2009)
    5. cIAP1/2 are direct E3 ligases conjugating diverse typ es of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) . (PubMed id 21931591)1, 2 Bertrand M.J....Vandenabeele P. (2011)
    6. The USP19 deubiquitinase regulates the stability of c -IAP1 and c-IAP2. (PubMed id 21849505)1, 2 Mei Y....Yang X. (2011)
    7. CARD-mediated autoinhibition of cIAP1's E3 ligase act ivity suppresses cell proliferation and migration. (PubMed id 21549626)1, 2 Lopez J....Meier P. (2011)
    8. Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. (PubMed id 21653699)1, 2 Cartier J....Dubrez L. (2011)
    9. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 329 HGNC: 590 AceView: BIRC2 Ensembl:ENSG00000110330 euGenes: HUgn329
    ECgene: BIRC2 Kegg: 329 H-InvDB: BIRC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BIRC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/birc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BIRC2 gene:
    Search GeneIP for patents involving BIRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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