BIRC2 Gene
protein-coding GIFtS: 67
GCID: GC11P102252
|
|
baculoviral IAP repeat containing 2(Previous name: baculoviral IAP repeat-containing 2 )
(Previous symbol: API1)
| |
Aliases
for BIRC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Baculoviral IAP Repeat Containing 21 2 | | HIAP22 5 | | API11 2 3 5 | | Hiap-22 | | MIHB1 2 3 | | Hiap-22 | | RNF481 2 3 | | Apoptosis Inhibitor 12 | | Baculoviral IAP Repeat-Containing 21 2 | | Baculoviral IAP Repeat-Containing Protein 22 | | C-IAP13 | | NFR2-TRAF Signalling Complex Protein2 | | CIAP11 | | C-IAP13 | | Inhibitor Of Apoptosis Protein 22 3 | | EC 6.3.2.-3 | | IAP-22 3 | | IAP23 | | IAP Homolog B2 3 | | HIAP-21 | | RING Finger Protein 482 3 | | HIAP22 5 | | TNFR2-TRAF-Signaling Complex Protein 22 3 | | |
Export aliases for BIRC2 gene to outside databasesPrevious GC identifers: GC11P104413 GC11P103575 GC11P101757 GC11P101755 GC11P101723 GC11P098144 |
Summaries
for BIRC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BIRC2:
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumornecrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-likeproteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer offree radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatorysignaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonicalNF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway andsuppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC,MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator ofinnate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I likereceptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneousformation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in acaspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle
Gene Wiki entry for BIRC2
|
Genomic Views
for BIRC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BIRC2 gene promoter:
TBP AP-1 p53 SRF (504 AA) ATF-2 Nkx2-5 HOXA5 TFIID c-Jun ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for BIRC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22BIRC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P102252: view genomic region
(about GC identifiers)
Start:
|
102,217,942 bp from pter |
End:
|
102,249,401 bp from pter |
Size:
|
31,460 bases |
Orientation:
|
plus strand |
|
Proteins
for BIRC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490 (See
protein sequence)Recommended Name: Baculoviral IAP repeat-containing protein 2 Size: 618 amino acids; 69900 Da
Subunit: Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.Interacts with CASP9. Interacts (via BIR domains) with TRAF2. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4,BIRC5/survivin and USP19
Subcellular location: Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathwayspromote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody intelophase cells, and found diffusely in the nucleus of interphase cells
6/12 PDB 3D structures from  and Proteopedia  for BIRC2 (see all 12):1QBH (3D)
2L9M (3D)
3D9T (3D)
3D9U (3D)
3M1D (3D)
3MUP (3D)
Secondary accessions: B4E026 Q16516 Q4TTG0Alternative splicing: 2 isoforms: Q13490-1 Q13490-2 Explore the universe of human proteins at neXtProt for BIRC2: NX_Q13490
Post-translational modifications:
Auto-ubiquitinated and degraded by the proteasome in apoptotic cells1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13490
BIRC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001157.1 NP_001243092.1 NP_001243095.1
ENSEMBL proteins: ENSP00000432410 ENSP00000431723 ENSP00000433851 ENSP00000227758 ENSP00000434979 ENSP00000436741 ENSP00000434708 ENSP00000434557 Reactome Protein details: Q13490
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
BIRC2 for ontologies About GeneDecksing
BIRC2 Antibody Products:
Assay Products for BIRC2: |
Protein
Domains /
Families
for BIRC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BIRC2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13490ProtoNet protein and cluster: Q13490 3 Blocks protein families: IPB001315 CARD interaction domain IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR) IPB001841 Zn-finger
UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490Domain: The BIR domains mediate nuclear localizationDomain: The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligaseactivity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activationSimilarity: Belongs to the IAP familySimilarity: Contains 3 BIR repeatsSimilarity: Contains 1 CARD domainSimilarity: Contains 1 RING-type zinc finger |
Function
for BIRC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatorysignaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis.Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonicalNF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway andsuppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC,MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator ofinnate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I likereceptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneousformation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in acaspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycleEnzyme regulation: The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domaindimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability ofBIRC2/c-IAP1 by preventing its ubiquitinationEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BIRC2 (NM_001166) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIRC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
BIRC2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BIRC2:
Animal Models:
Mouse knock-outs for BIRC2: Birc2tm1.1Rbr Birc2tm1Jda
9 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Birc2):
BIRC2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BIRC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TWEAK Pathway | | | 2 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 4 | Apoptosis and survival_Lymphotoxin-beta receptor signaling | | | 5 | Apoptosis and survival_Apoptotic TNF-family pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for BIRC2
1  R&D Systems Pathway for BIRC2
5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BIRC2 (see all 15)
1 
Cell Signaling Technology (CST) Pathway for BIRC2
5  GeneGo (Thomson Reuters) Pathways for BIRC2
5/10  BioSystems Pathways for BIRC2 (see all 10)
5/14 
Reactome Pathways for BIRC2 (see all 14)
1  PharmGKB Pathway for BIRC2
5/7 
Kegg Pathways (Kegg details for BIRC2) (see all 7):
BIRC2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIRC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/101 Interacting proteins for BIRC2 (Q134901, 2, 3 ENSP000002277584) via UniProtKB, MINT, STRING, and/or I2D (see all 101)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| JUP | P149232, 3, ENSP000003111134 | MINT-66507 I2D:
score=5 STRING: ENSP00000311113 | | RIPK2 | O433531, 3, ENSP000002207514 | EBI-514538,EBI-358522 I2D:
score=4 STRING: ENSP00000220751 | | RIPK3 | Q9Y5721, 3, ENSP000002162744 | EBI-514538,EBI-358587 I2D:
score=1 STRING: ENSP00000216274 | | CASP7 | P552101, 3 | EBI-514538,EBI-523958 I2D:
score=5 | | TRAF2 | Q129331, 3, ENSP000002476684 | EBI-514538,EBI-1046651 I2D:
score=10 STRING: ENSP00000247668 |
About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table
BIRC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for BIRC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BIRC2 for compounds About GeneDecksing
 Browse Tocris compounds for BIRC2
10/30 Novoseek chemical compound relationships for BIRC2 gene (see all 30) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ciap1 |
97.1 |
153 |
15265700 (10), 19893574 (7), 20356846 (7), 15665297 (7) (see all 23) |
| ciap2 |
92.4 |
20 |
18997792 (3), 17972100 (2), 15380346 (2), 19269012 (2) (see all 10) |
| sp 600125 |
51.5 |
4 |
17133355 (1), 18343029 (1) |
| curcumin |
48.9 |
5 |
16243823 (1), 19372569 (1), 18386790 (1), 16219905 (1) (see all 5) |
| etoposide |
43.4 |
6 |
11071269 (2), 15050749 (1), 12243753 (1), 9384571 (1) |
| doxorubicin |
40.8 |
9 |
16618750 (3), 14666661 (2), 17521628 (2), 19351859 (1) (see all 5) |
| cisplatin |
38.4 |
9 |
16618750 (3), 11145600 (1), 20407239 (1), 11895917 (1) (see all 7) |
| paclitaxel |
38.3 |
4 |
16243823 (1), 16618750 (1), 19351859 (1), 14617792 (1) |
| wortmannin |
37.7 |
4 |
15995629 (2), 17074018 (1), 12888921 (1) |
| ly294002 |
36.6 |
1 |
17229588 (1) |
Search CenterWatch for drugs/clinical trials and news about BIRC2
|
Transcripts
for BIRC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BIRC2 gene (3 alternative transcripts): NM_001166.4 NM_001256163.1 NM_001256166.1 Unigene Cluster for BIRC2: Baculoviral IAP repeat containing 2 Hs.696238 [show with all ESTs]Unigene Representative Sequence: BC02857812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527808 ENST00000532832 ENST00000530675 ENST00000534646 ENST00000533742
ENST00000227758(uc001pgy.3 uc010ruq.2) ENST00000532672 ENST00000531259
ENST00000527465 ENST00000527910(uc010rur.2) ENST00000528344 ENST00000534130
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BIRC2 (NM_001166) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIRC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC2 |
Additional cDNA sequence: AK225856.1 AK303197.1 AK313446.1 BC016174.1 BC028578.1 BX647978.1 L49431.1 U37547.1 U45879.1 13 DOTS entries: DT.99955512 DT.455872 DT.101966491 DT.91808576 DT.99969815 DT.120734536 DT.95121789 DT.97806829 DT.100679229 DT.100730532 DT.102830794 DT.92444769 DT.95299594 24/250 AceView cDNA sequences (see all 250): BF509777 AA504096 BM785364 AI016580 AA702174 AA361629 BX647978 BU430339 AI718618 BU902159 N78871 AU131149 AW028956 NM_001166 CB132520 AA421225 BM674545 BQ884287 AA773975 BC016174 T73007 BC028578 T32378 BX642360
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BIRC2
|
Expression
for BIRC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BIRC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTAGTCTG
About this image
See BIRC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BIRC2
SOURCE GeneReport for Unigene cluster: Hs.696238
UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis,ovary, and pancreas, low or absent in brain and peripheral blood leukocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including BIRC2 (see all 9):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIRC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC2 |
Orthologs
for BIRC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BIRC2 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BIRC21 |
baculoviral IAP repeat containing 2 |
73.43(n)
72.99(a) |
|
374012 NM_001007822.1 NP_001007823.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
67(a) |
1 → many |
3(192311974-192322685) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.145082 |
Xenopus laevis transcribed sequence with weak similarity more |
75.78(n) |
|
BJ059822.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
birc32 |
baculoviral IAP repeat-containing 3 |
75.27(n) |
|
373107 AY247786.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Iap21 , 3 |
anti-apoptosis apoptosis inhibitor3
Inhibitor of apoptosis 21 |
29(a)3
45.1(n)1
36.97(a)1 |
|
2 52D23
367481 NM_057779.41 NP_477127.11 |
ENSEMBL Gene Tree for BIRC2 (if available)
TreeFam Gene Tree for BIRC2 (if available) |
Paralogs
for BIRC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BIRC2 gene
- BIRC32 BIRC72 XIAP2 BIRC82
4 SIMAP similar genes for BIRC2 using alignment to 7 protein entries: BIRC2_HUMAN (see all proteins):BIRC3 ILP3 BIRC7 XIAP
BIRC2 for paralogs About GeneDecksing
|
Genomic Variants
for BIRC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BIRC2 (102217942 - 102249401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BIRC2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC2 |
|
Disorders
/ Diseases
for BIRC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BIRC2 for disorders About GeneDecksing
OMIM gene information: 601712
OMIM disorders: --
20/65  diseases for BIRC2 (see all 65): About MalaCardsspinal muscular atrophy patent ductus arteriosus non-small cell lung carcinoma salivary gland cancer
anaplastic large cell lymphoma malignant pleural mesothelioma malt lymphoma non-hodgkin lymphoma
muscular atrophy squamous cell carcinoma burkitt's lymphoma adenoid cystic carcinoma
oral squamous cell carcinoma lymphoblastic leukemia esophageal squamous cell carcinoma hodgkin's lymphoma
pleomorphic adenoma ataxia telangiectasia acute lymphoblastic leukemia chronic lymphocytic leukemia
1 disease from the University of Copenhagen DISEASES database for BIRC2:Cancer 10/31 Novoseek disease relationships for BIRC2 gene (see all 31) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
62.2 |
20 |
20356846 (2), 8943045 (1), 11106668 (1), 15187025 (1) (see all 17) |
| tumors |
57 |
55 |
16983704 (3), 11484955 (3), 15187025 (2), 17154176 (2) (see all 32) |
| cancer |
45.9 |
26 |
18570872 (3), 18230607 (2), 18448338 (2), 19138149 (1) (see all 18) |
| leukemia |
45.1 |
1 |
16983704 (1) |
| prostate cancer |
31.4 |
6 |
15065090 (3), 19549337 (2), 11948968 (1) |
| carcinoma squamous cell |
31 |
7 |
15911110 (2), 18621506 (2), 11559525 (1), 12208731 (1) |
| myeloma |
29.6 |
2 |
16983704 (1) |
| lymphoma b-cell |
19.5 |
4 |
15187025 (1), 16983704 (1) |
| burkitt lymphoma |
16.9 |
1 |
16983704 (1) |
| colorectal cancer |
13.6 |
3 |
14708638 (2), 19578769 (1) |
Human Genome Epidemiology (HuGE) Navigator: BIRC2 (10 documents)
Export disorders for BIRC2 gene to outside databases
|
Publications
for BIRC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BIRC2 gene, integrated from 9 sources (see all 406):
(articles sorted by number of sources associating them with BIRC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 3 Liston P.... Korneluk R.G. (1996)
- The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)1, 2, 3 Rothe M.... Goeddel D.V. (1995)
- cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PubMed id 15665297)1, 2, 9 Samuel T....Reed J.C. (2005)
- The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. (PubMed id 19153467)1, 2, 9 Kulathila R....Price A. (2009)
- cIAP1/2 are direct E3 ligases conjugating diverse typ es of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) . (PubMed id 21931591)1, 2 Bertrand M.J....Vandenabeele P. (2011)
- The USP19 deubiquitinase regulates the stability of c -IAP1 and c-IAP2. (PubMed id 21849505)1, 2 Mei Y....Yang X. (2011)
- CARD-mediated autoinhibition of cIAP1's E3 ligase act ivity suppresses cell proliferation and migration. (PubMed id 21549626)1, 2 Lopez J....Meier P. (2011)
- Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. (PubMed id 21653699)1, 2 Cartier J....Dubrez L. (2011)
- IAPs: more than just inhibitors of apoptosis proteins . (PubMed id 18414036)1, 2 Dubrez-Daloz L....Cartier J. (2008)
- c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. (PubMed id 18082613)1, 2 Xu L....Yuan J. (2007)
|
External Searches for BIRC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BIRC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BIRC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BIRC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BIRC2 gene:
Search GeneIP for patents involving BIRC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BIRC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BIRC2 | | OriGene shRNA RFP for BIRC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIRC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIRC2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BIRC2 | | OriGene 3'-UTR Clone for BIRC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIRC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BIRC2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BIRC2 | | OriGene Custom Protein Services for BIRC2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BIRC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIRC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIRC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIRC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIRC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIRC2 |
| |
 |  |  |  | |
| | Antibodies & Assays for BIRC2 |
| | | | Search Tocris compounds for BIRC2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | BIRC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC2 |
|  |  |  | | | | ThermoFisher Antibodies for BIRC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC2 |
|
|
|
|
