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BIRC2 Gene

protein-coding GIFtS: 65

GC11P101723

baculoviral IAP repeat-containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: API1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
API1 ^², ³
C-IAP1 ^³
HIAP-2 ^³
HIAP2 ^², ³
Hiap-2 ^²
IAP2 ^³
MIHB ^¹, ², ³
RNF48 ^¹, ², ³
cIAP1 ^¹, ²
hiap-2 ^¹

Descriptions
IAP homolog B ^³
Inhibitor of apoptosis protein 2 ^³
NFR2-TRAF signalling complex protein ^²
RING finger protein 48 ^³
TNFR2-TRAF-signaling complex protein 2 ^³
apoptosis inhibitor 1 ^²
baculoviral IAP repeat-containing 2 ^²
baculoviral IAP repeat-containing protein 2 ^²

External Ids
HGNC: 590¹
Entrez Gene: 329²
UniProtKB: Q13490³
Ensembl: ENSG00000110330⁷

Search outside databases for aliases for BIRC2 gene

Previous GC identifers: GC11P104413 GC11P103575 GC11P102252 GC11P101757 GC11P101755

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BIRC2:

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by

binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by

interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced

by serum deprivation and menadione, a potent inducer of free radicals. [provided by RefSeq]

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490

Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated

factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the

tumor necrosis factor receptor 2 (TNFR2)

Gene Wiki entry for BIRC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BIRC2 gene

Entrez Gene cytogenetic band: 11q22 Ensembl cytogenetic band: 11q22.2 HGNC cytogenetic band: 11q22

BIRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P101723: (about GC identifiers)

Start:	101,723,176 bp from pter
End:	101,754,611 bp from pter
Size:	31,436 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490 (See protein sequence)

Recommended Name: Baculoviral IAP repeat-containing protein 2

Size: 618 amino acids; 69900 Da

Subunit: Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor

activity

Subcellular location: Cytoplasm (Potential)

PDB structures from and Proteopedia :

1QBH (3D)

3D9T (3D)

3D9U (3D)

Secondary accessions: Q16516 Q4TTG0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001157.1

ENSEMBL proteins:

ENSP00000227758

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BIRC2 (cIAP-1/HIAP-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (cIAP1)
	Human Recombinant Proteins from Abnova (BIRC2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	11106668

About this table

Antibodies for BIRC2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BIRC2
	Sigma-Aldrich Antibodies for BIRC2
	R&D Systems Antibodies for BIRC2 (cIAP-1/HIAP-2)
	Cell Signaling Technology (CST) Antibodies for BIRC2 (cIAP-1)
	Antibodies from Abcam (cIAP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BIRC2)
	Novus Biologicals Antibodies for BIRC2

Assays for BIRC2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13490

ProtoNet protein and cluster: Q13490

3 Blocks protein families:

IPB001315 CARD interaction domain

IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490

Similarity: Belongs to the IAP family

Similarity: Contains 3 BIR repeats

Similarity: Contains 1 CARD domain

Similarity: Contains 1 RING-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BIRC2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BIRC2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001166

Applied Biosystems Silencer® siRNAs for BIRC2

Sigma-Aldrich siRNA and siRNA Panels for BIRC2

Sigma-Aldrich shRNA Panels and shRNA for BIRC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BIRC2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001166
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001166
untagged cDNA clone in CMV expression vector: NM_001166

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001166

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490

Function: Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated

factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the

tumor necrosis factor receptor 2 (TNFR2)

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Birc2):

hematopoietic system

immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11084335 16282325 18022362
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for BIRC2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Lymphotoxin &beta
Death Receptor Signaling
Apoptosis Signaling
Amyotrophic Lateral Sclerosis Signaling
Molecular Mechanisms of Cancer

GeneDecks BIRC2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BIRC2

5/73 Interacting proteins for BIRC2 (Q13490^{1, 2} ENSP00000227758³) via UniProtKB, MINT, and/or STRING (see all 73 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP7	P55210¹, ENSP00000298700³	EBI-514538, EBI-523958 STRING (score=.999)
CASP9	P55211¹, ENSP00000330237³	EBI-514538, EBI-516799 STRING (score=.999)
DIABLO	Q9NR28¹, ENSP00000267169³	EBI-514538, EBI-517508 STRING (score=.999)
CASP3	P42574¹, ENSP00000311032³	EBI-514538, EBI-524064 STRING (score=.998)
TRAF2	Q12933¹, ENSP00000352685³	EBI-514538, EBI-355744 STRING (score=.967)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001890	placenta development	IEA	--
GO:0007166	cell surface receptor linked signal transduction	TAS	8548810
GO:0042981	regulation of apoptosis	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP	12761501

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BIRC2
9 Novoseek chemical compound relationships for BIRC2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ciap1	96.43	113	15265700 (10), 15665297 (7), 16282325 (6), 16510124 (6) (see all 17)
ciap2	92.84	18	18997792 (3), 17972100 (2), 15380346 (2), 16892011 (1) (see all 9)
sp 600125	55.08	4	17133355 (1), 18343029 (1)
wortmannin	40.22	4	15995629 (2), 17074018 (1), 12888921 (1)
bryostatin 1	36.20	4	10581168 (4)
oligonucleotide	1.73	3	15065090 (2), 17253596 (1)
agarose	0.29	1	9492068 (1)
zinc	0.00	1	18617897 (1)
vitamin-e	0.00	2	15566391 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BIRC2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BIRC2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001166

Sigma-Aldrich siRNA and siRNA Panels for BIRC2

Sigma-Aldrich shRNA Panels and shRNA for BIRC2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001166

REFSEQ mRNAs for BIRC2 gene:

NM_001166.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001166

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001166
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001166
                                 untagged cDNA clone in CMV expression vector: NM_001166

Additional cDNA sequence:

AK225856.1 AK303197.1 AK313446.1 BC016174.1 BC028578.1 BX647978.1 L49431.1 U37547.1

U45879.1

17 DOTS entries:

DT.99955512 DT.455872 DT.101966491 DT.91808576 DT.95121789 DT.92410067 DT.92444769 DT.99969815

DT.100679229 DT.120734536 DT.100038470 DT.100730532 DT.92444764 DT.97806829 DT.102830794 DT.92444767

DT.95299594

24/250 AceView cDNA sequences (see all 250 ):

BP341109 T73007 AU280325 R83678 CB132520 CB117702 AI278103 BM703963

BU633609 AA969704 AA773975 AA702174 AU131149 AA361629 BC016174 AI016580

BQ439248 BF509777 T32378 AI718618 N78871 AW028956 BC028578 BM800246

highest scoring ESTs for BIRC2:

U37547 AA190628 AA193578 AA194647 AA361629 AA421225 AA463671 AA504096 AA528657 AA564605

Unigene Cluster for BIRC2:

Baculoviral IAP repeat-containing 2

Hs.696238 [show with all ESTs]

Unigene Representative Sequence: BC028578

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12
SP1:					-														-
SP2:																			-
SP3:
SP4:					-		-
SP5:																	-		-

About this scheme

ECgene alternative splicing isoforms for BIRC2

1 Ensembl transcript including schematic representation:

ENST00000227758

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BIRC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BIRC2

¹ / ² / ³

3 probe-sets matching BIRC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36578_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U37547	1.00	0.90	0.95	1
202076_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001166	0.60	0.83	0.73	1
202076_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCTAGTCTG

SOURCE GeneReport for Unigene cluster: Hs.696238
Expression variation in blood from EXPOLDB for BIRC2
UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal
muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood
leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BIRC2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BIRC2¹	--	baculoviral IAP repeat-containing 2	85.66(n) 89.29(a)	479464 XM_858203.1 XP_863296.1
chimpanzee (Pan troglodytes)	BIRC2¹	--	baculoviral IAP repeat-containing 2	99.78(n) 99.84(a)	451508 XM_001152603.1 XP_001152603.1
rat (Rattus norvegicus)	Birc2¹	--	baculoviral IAP repeat-containing 2	82.57(n) 82.85(a)	60371 NM_021752.1 NP_068520.1
mouse (Mus musculus)	Birc2^{1, 5}	9⁵	baculoviral IAP repeat-containing 2^{1, 5}	84.59(n)¹ 84.59(a)¹	11797¹ NM_007465.1¹ NP_031491.1¹ AA473594⁵ AW146227⁵ (see all 10)
chicken (Gallus gallus)	BIRC2¹	--	baculoviral IAP repeat-containing 2	73.43(n) 72.99(a)	374012 NM_001007822.1 NP_001007823.1

About this table Species with no ortholog for BIRC2

ENSEMBL Gene Tree for BIRC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BIRC2 gene

BIRC3² BIRC7² ENSG00000163098² XIAP² BIRC8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/242 NCBI SNPs in BIRC2 are shown (see all 242 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 126)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11604189^1,2	A,C,F,H	101725073(+)	`AGTTTT/GTGAAC`	1	--	ut5¹		9	NS EU EA WA	578
	rs12792649^1,2	A,C,F,H	101725489(+)	`TTTAAT/CATTTT`	1	--	ut5¹		9	EU EA WA NS	604
	rs1318199^1,2	C,F,H	101723102(+)	`CTCCCG/CGGCGC`	1	--	ng5¹		10	MN EU EA WA NS	790
	rs12282509^1,2	C,F,H	101722208(+)	`ATTGGG/AGGAGT`	1	--	ng5¹		9	EU EA WA NS	596
--	rs1317775^1,2	C,F	101723016(+)	`CGGGCA/GTCCCT`	1	--	ng5¹		6	MN NS	374
--	rs12278022^1,2	C,F	101722331(+)	`AATTAT/CATGTG`	1	--	ng5¹		5	NS	178
--	rs33931521^1,2	C,F	101754361(+)	`TGTGT-/GGACCTA`	1	--	ut3¹		10	NS EU EA NA MN	616
	rs35806428^1,2	F	101754160(+)	`AAAAGG/ATCTTT`	1	--	ut3¹		5	NS	188
--	rs35001402^1,2	F	101725151(+)	`GACTTC/-CCCCA`	1	--	ut5¹		5	NS	180
	rs3210039^1,2	H	101724621(+)	`CTTTAT/AAAAGG`	1	--	ut5¹ ese³		5	MN EU EA WA	602

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HapMap Linkage Disequilibrium images for BIRC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601712

10/31 Novoseek disease relationships for BIRC2 gene (see all 31 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	61.70	17	8943045 (1), 11106668 (1), 15187025 (1), 17011514 (1) (see all 15)
tumors	55.06	50	16983704 (3), 11484955 (3), 15187025 (2), 10815900 (2) (see all 29)
leukemia	44.60	1	16983704 (1)
cancer	44.10	25	18570872 (3), 18230607 (2), 18448338 (2), 19138149 (1) (see all 17)
carcinoma squamous cell	34.14	7	15911110 (2), 18621506 (2), 11559525 (1), 12208731 (1)
myeloma	32.34	2	16983704 (1)
prostate cancer	31.19	4	15065090 (3), 11948968 (1)
lymphoma b-cell	23.21	4	15187025 (1), 16983704 (1)
burkitt lymphoma	19.91	1	16983704 (1)
leukemia lymphocytic chronic	13.84	1	16983704 (1)

About this table

Human Genome Epidemiology Navigator: BIRC2 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/300 PubMed articles for BIRC2 gene (see all 300 ):

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)^{2, 3, 4} Liston P.... Korneluk R.G. (1996)
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)^{2, 3, 4} Rothe M....Goeddel D.V. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. (PubMed id 10404221)^{3, 4} Hinds M.G.... Day C.L. (1999)
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. (PubMed id 8643514)^{3, 4} Uren A.G.... Vaux D.L. (1996)
Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue. (PubMed id 18621506)^{1, 3} Qi S....Omura K. (2008)
Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas. (PubMed id 15911110)^{1, 3} Tanimoto T....Matsubara O. (2005)
c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. (PubMed id 11106668)^{1, 3} Clem R.J....Hardwick J.M. (2001)
Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. (PubMed id 12208731)^{1, 3} Imoto I....Inazawa J. (2002)
hnRNP A1 regulates UV-induced NF-kappaB signalling through destabilization of cIAP1 mRNA. (PubMed id 18846111)^{1, 3} Zhao T.T....Holcik M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 329	HGNC: 590	AceView: BIRC2	Ensembl:ENSG00000110330	euGenes: HUgn329
ECgene: BIRC2	H-InvDB: BIRC2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BIRC2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/birc2/

Licensable Technologies for BIRC2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BIRC2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BIRC2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BIRC2		Antibodies for BIRC2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BIRC2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BIRC2)
	Antibodies (BIRC2)
	Chimera RNAi (BIRC2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for BIRC2 (cIAP-1)

	Recombinant Proteins (cIAP1)
	Antibodies (cIAP1)

Search OriGene for BIRC2

Search Tocris compounds for BIRC2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BIRC2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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BIRC2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for BIRC2

Summaries
for BIRC2

Genomic Location
for BIRC2

Proteins
for BIRC2

Protein Domains/
Families
for BIRC2

Gene Function
for BIRC2

Pathways & Interactions
for BIRC2

Drugs & Compounds
for BIRC2

Transcripts
for BIRC2

Expression
for BIRC2

Orthologs
for BIRC2

Paralogs
for BIRC2

SNPs/Variants
for BIRC2

Disorders & Mutations
for BIRC2

Medical News
for BIRC2

Publications
for BIRC2

Search for BIRC2

Genome Databases showing BIRC2

Other Databases showing BIRC2

Specialized Databases showing BIRC2

Licensable Technologies
for BIRC2

Services
for BIRC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BIRC2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor BIRC2

Summariesfor BIRC2

Genomic Locationfor BIRC2

Proteinsfor BIRC2

Protein Domains/Familiesfor BIRC2

Gene Functionfor BIRC2

Pathways & Interactionsfor BIRC2

Drugs & Compoundsfor BIRC2

Transcriptsfor BIRC2

Expression for BIRC2

Orthologsfor BIRC2

Paralogsfor BIRC2

SNPs/Variantsfor BIRC2

Disorders & Mutationsfor BIRC2

Medical Newsfor BIRC2

Publicationsfor BIRC2

Search for BIRC2

Genome Databases showing BIRC2

Other Databases showing BIRC2

Specialized Databases showing BIRC2

Licensable Technologiesfor BIRC2

Servicesfor BIRC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BIRC2

Summaries
for BIRC2

Genomic Location
for BIRC2

Proteins
for BIRC2

Protein Domains/
Families
for BIRC2

Gene Function
for BIRC2

Pathways & Interactions
for BIRC2

Drugs & Compounds
for BIRC2

Transcripts
for BIRC2

Expression
for BIRC2

Orthologs
for BIRC2

Paralogs
for BIRC2

SNPs/Variants
for BIRC2

Disorders & Mutations
for BIRC2

Medical News
for BIRC2

Publications
for BIRC2

Licensable Technologies
for BIRC2

Services
for BIRC2