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BIRC2 Gene

protein-coding   GIFtS: 66
GCID: GC11P102252

Baculoviral IAP Repeat Containing 2

(Previous name: baculoviral IAP repeat-containing 2)
(Previous symbol: API1)
  See BIRC2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Baculoviral IAP Repeat Containing 21 2     TNFR2-TRAF-Signaling Complex Protein 22 3
API11 2 3 5     HIAP22 5
Baculoviral IAP Repeat-Containing 21 2     Hiap-22
Apoptosis Inhibitor 11 2     Baculoviral IAP Repeat-Containing Protein 22
NFR2-TRAF Signalling Complex Protein1 2     c-IAP12
Inhibitor Of Apoptosis Protein 22 3     cIAP12
IAP-22 3     C-IAP13
MIHB2 3     EC 6.3.2.-3
RNF482 3     IAP23
IAP Homolog B2 3     hIAP-23
RING Finger Protein 482 3     hIAP23

External Ids:    HGNC: 5901   Entrez Gene: 3292   Ensembl: ENSG000001103307   OMIM: 6017125   UniProtKB: Q134903   

Export aliases for BIRC2 gene to outside databases

Previous GC identifers: GC11P104413 GC11P103575 GC11P101757 GC11P101755 GC11P101723 GC11P098144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BIRC2 Gene:
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor
necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like
proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer
of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for BIRC2 Gene:
BIRC2 (baculoviral IAP repeat containing 2) is a protein-coding gene. Diseases associated with BIRC2 include malt lymphoma. GO annotations related to this gene include ubiquitin-protein ligase activity and protein N-terminus binding. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion
and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both
canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator
of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8,
TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3
ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and
inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors
(TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition
receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex
that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses
ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1.
Plays a role in the modulation of the cell cycle

Gene Wiki entry for BIRC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BIRC2 gene promoter:
         TBP   AP-1   p53   SRF (504 AA)   ATF-2   Nkx2-5   HOXA5   TFIID   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BIRC2 promoter sequence
   Search Chromatin IP Primers for BIRC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.2   HGNC cytogenetic band: 11q22

BIRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIRC2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P102252:  view genomic region     (about GC identifiers)

Start:
102,217,942 bp from pter      End:
102,249,401 bp from pter
Size:
31,460 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490 (See protein sequence)
Recommended Name: Baculoviral IAP repeat-containing protein 2  
Size: 618 amino acids; 69900 Da
Subunit: Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.
Interacts with CASP9. Interacts (via BIR domains) with TRAF2; the interaction is required for IKBKE
ubiquitination. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19
Selected PDB 3D structures from and Proteopedia for BIRC2 (see all 16):
1QBH (3D)        2L9M (3D)        3D9T (3D)        3D9U (3D)        3M1D (3D)        3MUP (3D)    
Secondary accessions: B4E026 Q16516 Q4TTG0
Alternative splicing: 2 isoforms:  Q13490-1   Q13490-2   

Explore the universe of human proteins at neXtProt for BIRC2: NX_Q13490

Explore proteomics data for BIRC2 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells1
  • Ubiquitination2 at Lys19, Lys36, Lys40, Lys94, Lys126, Lys226, Lys233, Lys328, Lys416, Lys425,
                                 Lys441, Lys537
  • Modification sites at PhosphoSitePlus

  • See BIRC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001157.1  NP_001243092.1  NP_001243095.1  

    ENSEMBL proteins: 
     ENSP00000432410   ENSP00000431723   ENSP00000433851   ENSP00000227758   ENSP00000434979  
     ENSP00000436741   ENSP00000434708   ENSP00000434557  
    Reactome Protein details: Q13490

    BIRC2 Human Recombinant Protein Products:

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    Novus Biologicals BIRC2 Lysate
    Sino Biological Recombinant Protein for BIRC2
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BIRC2

     
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    BIRC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for BIRC2 (cIAP-1/HIAP-2)         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BIRC2
    Cloud-Clone Corp. CLIAs for BIRC2
    Search eBioscience for ELISAs for BIRC2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BIRC: Baculoviral IAP repeat containing
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR028795 C-IAP1
     IPR001841 Znf_RING
     IPR011029 DEATH-like_dom
     IPR001370 BIR
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q13490

    ProtoNet protein and cluster: Q13490

    3 Blocks protein domains:
    IPB001315 CARD interaction domain
    IPB001370 Baculovirus inhibitor of apoptosis protein repeat (BIR)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
    Domain: The BIR domains mediate nuclear localization
    Domain: The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein
    ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and
    activation
    Similarity: Belongs to the IAP family
    Similarity: Contains 3 BIR repeats
    Similarity: Contains 1 CARD domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with BIRC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIRC2_HUMAN, Q13490
    Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates
    inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion
    and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both
    canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator
    of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target
    proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8,
    TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3
    ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and
    inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors
    (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition
    receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex
    that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses
    ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1.
    Plays a role in the modulation of the cell cycle
    Enzyme regulation: The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING
    domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the
    E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability
    of BIRC2/c-IAP1 by preventing its ubiquitination

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IMP--
    GO:0004842ubiquitin-protein ligase activity IDA11907583
    GO:0005515protein binding IPI11084335
    GO:0008270zinc ion binding IDA19153467
    GO:0047485protein N-terminus binding IPI19153467
         
    Find genes that share ontologies with BIRC2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BIRC2:
     Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Birc2):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  normal 

    Find genes that share phenotypes with BIRC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BIRC2: Birc2tm1.1Rbr Birc2tm1Jda

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIRC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIRC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIRC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIRC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIRC2:
    hsa-mir-124-3p (MIRT022141), hsa-mir-204-5p (MIRT005820)

    Block miRNA regulation of human, mouse, rat BIRC2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BIRC2:
    hsa-miR-342-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidBIRC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BIRC2
    Predesigned siRNA for gene silencing in human, mouse, rat BIRC2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: BIRC2 (NM_001166)
    Sino Biological Human cDNA Clone for BIRC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIRC2
    Addgene plasmids for BIRC2 

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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIRC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BIRC2_HUMAN, Q13490: Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic
    pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with
    the midbody in telophase cells, and found diffusely in the nucleus of interphase cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane3
    mitochondrion2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001741XY body IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15665297
    GO:0005829cytosol TAS--
    GO:0009898cytoplasmic side of plasma membrane ISS--

    Find genes that share ontologies with BIRC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BIRC2 About   (see all 34)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    Fas Signaling0.35
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4LT-BetaR Pathway
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46
    LT-BetaR Pathway0.46
    5Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42


    Find genes that share SuperPaths with BIRC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for BIRC2
        NOD-like Receptor Signaling Pathways
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BIRC2 (see all 15)
        Caspase Cascade
    TWEAK Pathway
    LT-BetaR Pathway
    TRAF Pathway
    Mitochondrial Apoptosis

    1 Cell Signaling Technology (CST) Pathway for BIRC2
        Apoptosis and Autophagy

    5 GeneGo (Thomson Reuters) Pathways for BIRC2
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for BIRC2 (see all 10)
        Focal Adhesion
    Apoptosis
    Apoptosis Modulation and Signaling
    TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway

    1 Sino Biological Pathway for BIRC2
        Death Receptor Signaling

    3 Reactome Pathways for BIRC2
        IKK complex recruitment mediated by RIP1
    Apoptotic cleavage of cellular proteins
    NOD1/2 Signaling Pathway

    1 PharmGKB Pathway for BIRC2
        Busulfan Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for BIRC2) (see all 10):
        NF-kappa B signaling pathway
    Ubiquitin mediated proteolysis
    Apoptosis
    Hippo signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC2 (see all 9): 
              NFKB Signaling Targets in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BIRC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIRC2 (Q134901, 2, 3 ENSP000002277584) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUPP149232, 3, ENSP000003111134MINT-66507 I2D: score=5 STRING: ENSP00000311113
    RIPK2O433531, 3, ENSP000002207514EBI-514538,EBI-358522 I2D: score=4 STRING: ENSP00000220751
    RIPK3Q9Y5721, 3, ENSP000002162744EBI-514538,EBI-298250 I2D: score=1 STRING: ENSP00000216274
    RAC1P630001, 2EBI-514538,EBI-413628 MINT-8319053 MINT-8313553
    CASP7P552101, 3EBI-514538,EBI-523958 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA11907583
    GO:0001666response to hypoxia IEA--
    GO:0001890placenta development IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with BIRC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIRC2

    Selected Novoseek inferred chemical compound relationships for BIRC2 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap1 97.1 153 15265700 (10), 19893574 (7), 20356846 (7), 15665297 (7) (see all 23)
    ciap2 92.4 20 18997792 (3), 17972100 (2), 15380346 (2), 19269012 (2) (see all 10)
    sp 600125 51.5 4 17133355 (1), 18343029 (1)
    curcumin 48.9 5 16243823 (1), 19372569 (1), 18386790 (1), 16219905 (1) (see all 5)
    etoposide 43.4 6 11071269 (2), 15050749 (1), 12243753 (1), 9384571 (1)
    doxorubicin 40.8 9 16618750 (3), 14666661 (2), 17521628 (2), 19351859 (1) (see all 5)
    cisplatin 38.4 9 16618750 (3), 11145600 (1), 20407239 (1), 11895917 (1) (see all 7)
    paclitaxel 38.3 4 16243823 (1), 16618750 (1), 19351859 (1), 14617792 (1)
    wortmannin 37.7 4 15995629 (2), 17074018 (1), 12888921 (1)
    ly294002 36.6 1 17229588 (1)



    Find genes that share compounds with BIRC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BIRC2 gene (3 alternative transcripts): 
    NM_001166.4  NM_001256163.1  NM_001256166.1  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527808 ENST00000532832 ENST00000530675 ENST00000534646 ENST00000533742
    ENST00000227758(uc001pgy.3 uc010ruq.2) ENST00000532672 ENST00000531259
    ENST00000527465 ENST00000527910(uc010rur.2) ENST00000528344 ENST00000534130

    miRNA
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    Block miRNA regulation of human, mouse, rat BIRC2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BIRC2:
    hsa-miR-342-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidBIRC2 3' UTR sequence
    Inhib. RNA
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    Selected AceView cDNA sequences (see all 250):

    BP341109 AI718618 AA706695 NM_001166 BC028578 AA281679 AI016580 BM785364 
    CB132520 AI989376 R83678 AA702174 AI278103 BM800246 BU430339 BU633609 
    AA773975 BM674545 BC016174 AI188555 BG188190 CB160209 BG028431 T73007 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                         -                                             
    SP2:                                                        -                                             
    SP3:                                                                                                      
    SP4:              -     -                                                                                 
    SP5:                                                  -     -                                             


    ECgene alternative splicing isoforms for BIRC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BIRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTAGTCTG
    BIRC2 Expression
    About this image


    BIRC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    BIRC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIRC2 Protein Expression

    UniProtKB/Swiss-Prot: BIRC2_HUMAN, Q13490
    Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus,
    testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIRC2 (see all 9): 
              NFKB Signaling Targets in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for BIRC2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Birc21 , 5 baculoviral IAP repeat-containing 21, 5 84.32(n)1
    84.59(a)1
      9 (2.46 cM)5
    117971  NM_007465.21  NP_031491.21 
     78182365 
    chicken
    (Gallus gallus)
    Aves BIRC21 baculoviral IAP repeat containing 2 73.3(n)
    72.91(a)
      374012  NM_001007822.1  NP_001007823.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    3(192311974-192323674)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145082 Xenopus laevis transcribed sequence with weak similarity more 75.78(n)    BJ059822.1 
    zebrafish
    (Danio rerio)
    Actinopterygii birc32 baculoviral IAP repeat-containing 3 75.27(n)   373107  AY247786.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Iap21 , 3 anti-apoptosis apoptosis inhibitor3
    Inhibitor of apoptosis 21
    29(a)3
    45.47(n)1
    37.47(a)1
      2 52D23
    367481  NM_176182.21  NP_788362.11 


    ENSEMBL Gene Tree for BIRC2 (if available)
    TreeFam Gene Tree for BIRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BIRC2 gene
    BIRC32  BIRC72  NLRC42  NAIP2  XIAP2  BIRC82  
    4 SIMAP similar genes for BIRC2 using alignment to 7 protein entries:     BIRC2_HUMAN (see all proteins):
    BIRC3    ILP3    BIRC7    XIAP

    Find genes that share paralogs with BIRC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BIRC2 (see all 780)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914759941,2
    --102216057(+) TTAGGA/GCGTTT 2 -- us2k10--------
    rs1496987931,2
    C--102216096(+) GGCTTC/TATTGT 2 -- us2k10--------
    rs351132671,2
    C,F--102216247(+) TTAAGA/CTTAAC 3 -- us2k15Minor allele frequency- C:0.00NS 186
    rs1454433801,2
    --102216309(+) CTGAAC/TTAACT 3 -- us2k10--------
    rs1488269241,2
    --102216324(+) GTAACA/GCTAGA 3 -- us2k10--------
    rs1469983661,2
    --102216364(+) GAGGTA/GCTATT 3 -- us2k10--------
    rs1168450461,2
    C,F--102216518(+) CTTGAG/TTTCAG 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1476543521,2
    --102216553(+) TTTTCC/TCACAT 3 -- us2k10--------
    rs1149285481,2
    C,F--102216664(+) TGGGAG/ACCATG 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs352066131,2
    C,F--102216729(+) CATTGG/AAACAG 3 -- us2k14Minor allele frequency- A:0.03NA 126

    HapMap Linkage Disequilibrium report for BIRC2 (102217942 - 102249401 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BIRC2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIRC2
    DNA2.0 Custom Variant and Variant Library Synthesis for BIRC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601712    OMIM disorders: --

    1 disease for BIRC2:    
    About MalaCards
    malt lymphoma

    1 disease from the University of Copenhagen DISEASES database for BIRC2:
    Cancer

    Find genes that share disorders with BIRC2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BIRC2 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 62.2 20 20356846 (2), 8943045 (1), 11106668 (1), 15187025 (1) (see all 17)
    tumors 57 55 16983704 (3), 11484955 (3), 15187025 (2), 17154176 (2) (see all 32)
    cancer 45.9 26 18570872 (3), 18230607 (2), 18448338 (2), 19138149 (1) (see all 18)
    leukemia 45.1 1 16983704 (1)
    prostate cancer 31.4 6 15065090 (3), 19549337 (2), 11948968 (1)
    carcinoma squamous cell 31 7 15911110 (2), 18621506 (2), 11559525 (1), 12208731 (1)
    myeloma 29.6 2 16983704 (1)
    lymphoma b-cell 19.5 4 15187025 (1), 16983704 (1)
    burkitt lymphoma 16.9 1 16983704 (1)
    colorectal cancer 13.6 3 14708638 (2), 19578769 (1)

    Genetic Association Database (GAD): BIRC2
    Human Genome Epidemiology (HuGE) Navigator: BIRC2 (10 documents)

    Export disorders for BIRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BIRC2 gene, integrated from 10 sources (see all 429):
    (articles sorted by number of sources associating them with BIRC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PubMed id 8552191)1, 2, 3 Liston P.... Korneluk R.G. (Nature 1996)
    2. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PubMed id 8548810)1, 2, 3 Rothe M.... Goeddel D.V. (Cell 1995)
    3. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PubMed id 15665297)1, 2, 9 Samuel T.... Reed J.C. (Cancer Res. 2005)
    4. The structure of the BIR3 domain of cIAP1 in complex with the N- terminal peptides of SMAC and caspase-9. (PubMed id 19153467)1, 2, 9 Kulathila R.... Price A. (Acta Crystallogr. D 2009)
    5. IKKI/-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. (PubMed id 23453969)1, 2 Zhou A.Y....Hahn W.C. (Cell Rep 2013)
    6. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). (PubMed id 21931591)1, 2 Bertrand M.J.... Vandenabeele P. (PLoS ONE 2011)
    7. The USP19 deubiquitinase regulates the stability of c-IAP1 and c- IAP2. (PubMed id 21849505)1, 2 Mei Y.... Yang X. (J. Biol. Chem. 2011)
    8. CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. (PubMed id 21549626)1, 2 Lopez J....Meier P. (Mol. Cell 2011)
    9. Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. (PubMed id 21653699)1, 2 Cartier J.... Dubrez L. (J. Biol. Chem. 2011)
    10. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 329 HGNC: 590 AceView: BIRC2 Ensembl:ENSG00000110330 euGenes: HUgn329
    ECgene: BIRC2 Kegg: 329 H-InvDB: BIRC2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BIRC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIRC2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/birc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BIRC2 gene:
    Search GeneIP for patents involving BIRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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