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Aliases for BIRC2 Gene

Aliases for BIRC2 Gene

  • Baculoviral IAP Repeat Containing 2 2 3
  • HIAP2 3 4 6
  • API1 3 4 6
  • TNFR2-TRAF-Signaling Complex Protein 2 3 4
  • NFR2-TRAF Signalling Complex Protein 2 3
  • Baculoviral IAP Repeat-Containing 2 2 3
  • Inhibitor Of Apoptosis Protein 2 3 4
  • RING Finger Protein 48 3 4
  • Apoptosis Inhibitor 1 2 3
  • IAP Homolog B 3 4
  • Hiap-2 3 4
  • C-IAP1 3 4
  • IAP-2 3 4
  • RNF48 3 4
  • MIHB 3 4
  • Baculoviral IAP Repeat-Containing Protein 2 3
  • EC 6.3.2.- 4
  • CIAP1 3
  • IAP2 4

External Ids for BIRC2 Gene

Previous Symbols for BIRC2 Gene

  • API1

Summaries for BIRC2 Gene

Entrez Gene Summary for BIRC2 Gene

  • The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for BIRC2 Gene

BIRC2 (Baculoviral IAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with BIRC2 include malt lymphoma. Among its related pathways are Pathways in cancer and ERK Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and protein N-terminus binding. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC2 Gene

  • Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Gene Wiki entry for BIRC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC2 Gene

Genomics for BIRC2 Gene

Genomic Location for BIRC2 Gene

Start:
102,347,182 bp from pter
End:
102,378,670 bp from pter
Size:
31,489 bases
Orientation:
Plus strand

Genomic View for BIRC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC2 Gene

Regulatory Elements for BIRC2 Gene

Proteins for BIRC2 Gene

  • Protein details for BIRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13490-BIRC2_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 2
    Protein Accession:
    Q13490
    Secondary Accessions:
    • B4E026
    • Q16516
    • Q4TTG0

    Protein attributes for BIRC2 Gene

    Size:
    618 amino acids
    Molecular mass:
    69900 Da
    Quaternary structure:
    • Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2; the interaction is required for IKBKE ubiquitination. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19.

    Three dimensional structures from OCA and Proteopedia for BIRC2 Gene

    Alternative splice isoforms for BIRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC2 Gene

Proteomics data for BIRC2 Gene at MOPED

Post-translational modifications for BIRC2 Gene

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys19, Lys36, Lys40, Lys94, Lys126, Lys226, Lys233, Lys328, Lys416, Lys425, Lys441, and Lys537

No data available for DME Specific Peptides for BIRC2 Gene

Domains for BIRC2 Gene

Gene Families for BIRC2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • BIRC :Baculoviral IAP repeat containing

UniProtKB/Swiss-Prot:

BIRC2_HUMAN
Domain:
  • The BIR domains mediate nuclear localization.:
    • Q13490
  • The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activation.:
    • Q13490
  • Contains 1 CARD domain.:
    • Q13490
Family:
  • Belongs to the IAP family.:
    • Q13490
Similarity:
  • Contains 3 BIR repeats.:
    • Q13490
  • Contains 1 RING-type zinc finger.:
    • Q13490
genes like me logo Genes that share domains with BIRC2: view

Function for BIRC2 Gene

Molecular function for BIRC2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination.
UniProtKB/Swiss-Prot Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Enzyme Numbers (IUBMB) for BIRC2 Gene

Gene Ontology (GO) - Molecular Function for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IMP 21653699
GO:0004842 ubiquitin-protein transferase activity IDA 11907583
GO:0005515 protein binding IPI 11084335
GO:0008270 zinc ion binding IDA 19153467
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with BIRC2: view
genes like me logo Genes that share phenotypes with BIRC2: view

Animal Models for BIRC2 Gene

MGI Knock Outs for BIRC2:

miRNA for BIRC2 Gene

miRTarBase miRNAs that target BIRC2

No data available for Transcription Factor Targeting and HOMER Transcription for BIRC2 Gene

Localization for BIRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC2 Gene

Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC2 Gene COMPARTMENTS Subcellular localization image for BIRC2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IDA 15665297
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005876 NOT spindle microtubule IBA --
genes like me logo Genes that share ontologies with BIRC2: view

Pathways for BIRC2 Gene

genes like me logo Genes that share pathways with BIRC2: view

Gene Ontology (GO) - Biological Process for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 11907583
GO:0001666 response to hypoxia IEA --
GO:0001890 placenta development IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with BIRC2: view

Compounds for BIRC2 Gene

(30) Novoseek inferred chemical compound relationships for BIRC2 Gene

Compound -log(P) Hits PubMed IDs
ciap1 97.1 84
ciap2 92.4 15
sp 600125 51.5 2
curcumin 48.9 5
etoposide 43.4 5
genes like me logo Genes that share compounds with BIRC2: view

Transcripts for BIRC2 Gene

Unigene Clusters for BIRC2 Gene

Baculoviral IAP repeat containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: -

Relevant External Links for BIRC2 Gene

GeneLoc Exon Structure for
BIRC2
ECgene alternative splicing isoforms for
BIRC2

Expression for BIRC2 Gene

mRNA expression in normal human tissues for BIRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIRC2 Gene

SOURCE GeneReport for Unigene cluster for BIRC2 Gene Hs.696238

mRNA Expression by UniProt/SwissProt for BIRC2 Gene

Q13490-BIRC2_HUMAN
Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes
genes like me logo Genes that share expressions with BIRC2: view

Orthologs for BIRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC2 36
  • 99.78 (n)
  • 99.84 (a)
BIRC2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BIRC2 37
  • 89 (a)
OneToOne
LOC539314 36
  • 90.99 (n)
  • 90.17 (a)
dog
(Canis familiaris)
Mammalia BIRC2 36
  • 85.74 (n)
  • 89.93 (a)
BIRC2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc2 36
  • 84.32 (n)
  • 84.59 (a)
Birc2 16
Birc2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
ManyToMany
-- 37
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Birc2 36
  • 82.17 (n)
  • 82.68 (a)
chicken
(Gallus gallus)
Aves BIRC2 36
  • 73.3 (n)
  • 72.91 (a)
ITA 37
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 68 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.14508 36
tropical clawed frog
(Silurana tropicalis)
Amphibia birc2 36
  • 64.03 (n)
  • 60.14 (a)
Str.8459 36
zebrafish
(Danio rerio)
Actinopterygii birc2 36
  • 61.93 (n)
  • 58.7 (a)
birc2 37
  • 53 (a)
OneToMany
birc3 36
fruit fly
(Drosophila melanogaster)
Insecta Iap2 36
  • 45.47 (n)
  • 37.47 (a)
Iap2 37
  • 33 (a)
ManyToMany
th 37
  • 23 (a)
ManyToMany
Iap2 38
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 55 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
Species with no ortholog for BIRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC2 Gene

ENSEMBL:
Gene Tree for BIRC2 (if available)
TreeFam:
Gene Tree for BIRC2 (if available)

Paralogs for BIRC2 Gene

Paralogs for BIRC2 Gene

Selected SIMAP similar genes for BIRC2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BIRC2: view

Variants for BIRC2 Gene

Sequence variations from dbSNP and Humsavar for BIRC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs523356 -- 102,376,945(+) CAACT(C/G)AAACC intron-variant
rs637708 -- 102,358,477(-) atgga(C/T)ctaac intron-variant
rs651602 -- 102,376,186(+) AAAGG(C/G)CAAGT intron-variant
rs1049460 -- 102,349,678(+) CTTGG(A/T)AATTC utr-variant-5-prime, intron-variant
rs1049461 -- 102,349,840(+) AACAG(C/T)ACTGT utr-variant-5-prime, intron-variant

Relevant External Links for BIRC2 Gene

HapMap Linkage Disequilibrium report
BIRC2

No data available for Structural Variations from Database of Genomic Variants (DGV) for BIRC2 Gene

Disorders for BIRC2 Gene

(1) MalaCards Diseases for BIRC2 Gene

Search for BIRC2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BIRC2 Gene

(31) Novoseek inferred disease relationships for BIRC2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 62.2 18
tumors 57 41
cancer 45.9 22
leukemia 45.1 1
prostate cancer 31.4 6

Relevant External Links for BIRC2

Genetic Association Database (GAD)
BIRC2
Human Genome Epidemiology (HuGE) Navigator
BIRC2
genes like me logo Genes that share disorders with BIRC2: view

No data available for UniProtKB/Swiss-Prot for BIRC2 Gene

Publications for BIRC2 Gene

  1. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PMID: 15665297) Samuel T. … Reed J.C. (Cancer Res. 2005) 3 4 23
  2. The structure of the BIR3 domain of cIAP1 in complex with the N- terminal peptides of SMAC and caspase-9. (PMID: 19153467) Kulathila R. … Price A. (Acta Crystallogr. D 2009) 3 4 23
  3. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PMID: 8548810) Rothe M. … Goeddel D.V. (Cell 1995) 2 3 4
  4. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PMID: 8552191) Liston P. … Korneluk R.G. (Nature 1996) 2 3 4
  5. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. (PMID: 8643514) Uren A.G. … Vaux D.L. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4

Products for BIRC2 Gene

  • Addgene plasmids for BIRC2

Sources for BIRC2 Gene

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