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Aliases for BIRC2 Gene

Aliases for BIRC2 Gene

  • Baculoviral IAP Repeat Containing 2 2 3 5
  • TNFR2-TRAF-Signaling Complex Protein 2 3 4
  • NFR2-TRAF Signalling Complex Protein 2 3
  • Baculoviral IAP Repeat-Containing 2 2 3
  • Inhibitor Of Apoptosis Protein 2 3 4
  • RING Finger Protein 48 3 4
  • Apoptosis Inhibitor 1 2 3
  • IAP Homolog B 3 4
  • Hiap-2 3 4
  • C-IAP1 3 4
  • HIAP2 3 4
  • IAP-2 3 4
  • RNF48 3 4
  • API1 3 4
  • MIHB 3 4
  • EC 6.3.2.- 4
  • CIAP1 3
  • IAP2 4

External Ids for BIRC2 Gene

Previous HGNC Symbols for BIRC2 Gene

  • API1

Previous GeneCards Identifiers for BIRC2 Gene

  • GC11P104413
  • GC11P103575
  • GC11P102252
  • GC11P101757
  • GC11P101755
  • GC11P101723
  • GC11P098144

Summaries for BIRC2 Gene

Entrez Gene Summary for BIRC2 Gene

  • The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for BIRC2 Gene

BIRC2 (Baculoviral IAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with BIRC2 include lung cancer and lymphoma, malt, somatic. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include ligase activity and transcription coactivator activity. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC2 Gene

  • Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Gene Wiki entry for BIRC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC2 Gene

Genomics for BIRC2 Gene

Regulatory Elements for BIRC2 Gene

Promoters for BIRC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BIRC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BIRC2 Gene

Chromosome:
11
Start:
102,347,182 bp from pter
End:
102,378,670 bp from pter
Size:
31,489 bases
Orientation:
Plus strand

Genomic View for BIRC2 Gene

Genes around BIRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC2 Gene

Proteins for BIRC2 Gene

  • Protein details for BIRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13490-BIRC2_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 2
    Protein Accession:
    Q13490
    Secondary Accessions:
    • B4E026
    • Q16516
    • Q4TTG0

    Protein attributes for BIRC2 Gene

    Size:
    618 amino acids
    Molecular mass:
    69900 Da
    Quaternary structure:
    • Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2; the interaction is required for IKBKE ubiquitination. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19.

    Three dimensional structures from OCA and Proteopedia for BIRC2 Gene

    Alternative splice isoforms for BIRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC2 Gene

Proteomics data for BIRC2 Gene at MOPED

Post-translational modifications for BIRC2 Gene

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
  • Ubiquitination at Lys 19, Lys 36, Lys 40, Lys 94, Lys 126, Lys 233, Lys 328, Lys 416, Lys 425, Lys 441, and Lys 537
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for BIRC2 (cIAP-1/HIAP-2)
  • Cell Signaling Technology (CST) Antibodies for BIRC2 (cIAP1)

No data available for DME Specific Peptides for BIRC2 Gene

Domains & Families for BIRC2 Gene

Suggested Antigen Peptide Sequences for BIRC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13490

UniProtKB/Swiss-Prot:

BIRC2_HUMAN :
  • The BIR domains mediate nuclear localization.
  • Belongs to the IAP family.
  • Contains 3 BIR repeats.
Domain:
  • The BIR domains mediate nuclear localization.
  • The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activation.
  • Contains 1 CARD domain.
Family:
  • Belongs to the IAP family.
Similarity:
  • Contains 3 BIR repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with BIRC2: view

Function for BIRC2 Gene

Molecular function for BIRC2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination.
UniProtKB/Swiss-Prot Function:
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Enzyme Numbers (IUBMB) for BIRC2 Gene

Gene Ontology (GO) - Molecular Function for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with BIRC2: view
genes like me logo Genes that share phenotypes with BIRC2: view

Animal Models for BIRC2 Gene

MGI Knock Outs for BIRC2:

Animal Model Products

miRNA for BIRC2 Gene

miRTarBase miRNAs that target BIRC2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC2 Gene

Localization for BIRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC2 Gene

Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC2 Gene COMPARTMENTS Subcellular localization image for BIRC2 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
plasma membrane 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for BIRC2 Gene

Pathways & Interactions for BIRC2 Gene

genes like me logo Genes that share pathways with BIRC2: view

SIGNOR curated interactions for BIRC2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001890 placenta development IEA --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BIRC2: view

Drugs & Compounds for BIRC2 Gene

(29) Drugs for BIRC2 Gene - From: Novoseek, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
AEG40826 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
AT-406 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
AZD5582 Pharma 0
Birinapant Pharma antagonist inhibitor of apoptosis (IAP) antagonist 0

(12) Additional Compounds for BIRC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for BIRC2 Gene

Compound Action Cas Number
Mitomycin C Inhibits DNA synthesis,antibiotic and antitumor agent 1950-07-7
genes like me logo Genes that share compounds with BIRC2: view

Transcripts for BIRC2 Gene

Unigene Clusters for BIRC2 Gene

Baculoviral IAP repeat containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: -

Relevant External Links for BIRC2 Gene

GeneLoc Exon Structure for
BIRC2
ECgene alternative splicing isoforms for
BIRC2

Expression for BIRC2 Gene

mRNA expression in normal human tissues for BIRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BIRC2 Gene

This gene is overexpressed in Fetal Brain (25.6), Peripheral blood mononuclear cells (16.5), Testis (13.9), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIRC2 Gene



SOURCE GeneReport for Unigene cluster for BIRC2 Gene Hs.696238

mRNA Expression by UniProt/SwissProt for BIRC2 Gene

Q13490-BIRC2_HUMAN
Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with BIRC2: view

Protein tissue co-expression partners for BIRC2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BIRC2 Gene

Orthologs for BIRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC539314 35
  • 90.99 (n)
  • 90.17 (a)
BIRC2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC2 35
  • 85.74 (n)
  • 89.93 (a)
BIRC2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc2 35
  • 84.32 (n)
  • 84.59 (a)
Birc2 16
Birc2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIRC2 35
  • 99.78 (n)
  • 99.84 (a)
BIRC2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Birc2 35
  • 82.17 (n)
  • 82.68 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves BIRC2 35
  • 73.3 (n)
  • 72.91 (a)
ITA 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia birc2 35
  • 64.03 (n)
  • 60.14 (a)
Str.8459 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14508 35
zebrafish
(Danio rerio)
Actinopterygii birc2 35
  • 61.93 (n)
  • 58.7 (a)
birc3 35
birc2 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Iap2 37
  • 29 (a)
Iap2 35
  • 45.47 (n)
  • 37.47 (a)
Iap2 36
  • 33 (a)
ManyToMany
th 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for BIRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC2 Gene

ENSEMBL:
Gene Tree for BIRC2 (if available)
TreeFam:
Gene Tree for BIRC2 (if available)

Paralogs for BIRC2 Gene

Paralogs for BIRC2 Gene

(4) SIMAP similar genes for BIRC2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BIRC2: view

Variants for BIRC2 Gene

Sequence variations from dbSNP and Humsavar for BIRC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_025016 -
rs34510872 - 102,377,646(+) ACAAG(C/T)GAGAG reference, missense
rs35494784 - 102,377,880(+) ATATT(C/T)CAACA reference, missense
rs34749508 - 102,368,541(+) GAAAT(A/G)GCATC reference, missense
rs523356 -- 102,376,945(+) CAACT(C/G)AAACC intron-variant

Variation tolerance for BIRC2 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BIRC2 Gene

HapMap Linkage Disequilibrium report
BIRC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BIRC2 Gene

Disorders for BIRC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BIRC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
lymphoma, malt, somatic
  • malt lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search BIRC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BIRC2

Genetic Association Database (GAD)
BIRC2
Human Genome Epidemiology (HuGE) Navigator
BIRC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIRC2
genes like me logo Genes that share disorders with BIRC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC2 Gene

Publications for BIRC2 Gene

  1. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PMID: 8552191) Liston P. … Korneluk R.G. (Nature 1996) 2 3 4 67
  2. NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response. (PMID: 19893574) Graber T.E. … Holcik M. (Cell Death Differ. 2010) 3 23
  3. Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. (PMID: 20097753) Mao A.P. … Shu H.B. (J. Biol. Chem. 2010) 3 23
  4. cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand. (PMID: 18827186) Dupoux A. … Dubrez-Daloz L. (Blood 2009) 3 23
  5. hnRNP A1 regulates UV-induced NF-kappaB signalling through destabilization of cIAP1 mRNA. (PMID: 18846111) Zhao T.T. … Holcik M. (Cell Death Differ. 2009) 3 23

Products for BIRC2 Gene

Sources for BIRC2 Gene

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