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Aliases for BIN3 Gene

Aliases for BIN3 Gene

  • Bridging Integrator 3 2 3 5

External Ids for BIN3 Gene

Previous GeneCards Identifiers for BIN3 Gene

  • GC08P022082
  • GC08M022831
  • GC08M022298
  • GC08M022499
  • GC08M022533
  • GC08M021021
  • GC08M022477

Summaries for BIN3 Gene

Entrez Gene Summary for BIN3 Gene

  • The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for BIN3 Gene

BIN3 (Bridging Integrator 3) is a Protein Coding gene. GO annotations related to this gene include cytoskeletal adaptor activity.

UniProtKB/Swiss-Prot for BIN3 Gene

  • Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Gene Wiki entry for BIN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIN3 Gene

Genomics for BIN3 Gene

Regulatory Elements for BIN3 Gene

Enhancers for BIN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BIN3 on UCSC Golden Path with GeneCards custom track

Promoters for BIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BIN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BIN3 Gene

Chromosome:
8
Start:
22,620,418 bp from pter
End:
22,669,148 bp from pter
Size:
48,731 bases
Orientation:
Minus strand

Genomic View for BIN3 Gene

Genes around BIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIN3 Gene

Proteins for BIN3 Gene

  • Protein details for BIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQY0-BIN3_HUMAN
    Recommended name:
    Bridging integrator 3
    Protein Accession:
    Q9NQY0
    Secondary Accessions:
    • Q9BVG2
    • Q9NVY9

    Protein attributes for BIN3 Gene

    Size:
    253 amino acids
    Molecular mass:
    29665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01223.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIN3 Gene

Proteomics data for BIN3 Gene at MOPED

Post-translational modifications for BIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIN3 Gene

No data available for DME Specific Peptides for BIN3 Gene

Domains & Families for BIN3 Gene

Protein Domains for BIN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BIN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQY0

UniProtKB/Swiss-Prot:

BIN3_HUMAN :
  • Contains 1 BAR domain.
Domain:
  • Contains 1 BAR domain.
genes like me logo Genes that share domains with BIN3: view

No data available for Gene Families for BIN3 Gene

Function for BIN3 Gene

Molecular function for BIN3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cytokinesis and septation where it has a role in the localization of F-actin.
genes like me logo Genes that share phenotypes with BIN3: view

Animal Models for BIN3 Gene

MGI Knock Outs for BIN3:

Animal Model Products

miRNA for BIN3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIN3 Gene

Localization for BIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIN3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIN3 Gene COMPARTMENTS Subcellular localization image for BIN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for BIN3 Gene

Pathways & Interactions for BIN3 Gene

SuperPathways for BIN3 Gene

No Data Available

Interacting Proteins for BIN3 Gene

Gene Ontology (GO) - Biological Process for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 11274158
GO:0000917 barrier septum assembly IEA --
GO:0008104 protein localization IMP 11274158
GO:0010591 regulation of lamellipodium assembly IEA --
GO:0014839 myoblast migration involved in skeletal muscle regeneration IEA --
genes like me logo Genes that share ontologies with BIN3: view

No data available for Pathways by source and SIGNOR curated interactions for BIN3 Gene

Drugs & Compounds for BIN3 Gene

No Compound Related Data Available

Transcripts for BIN3 Gene

Unigene Clusters for BIN3 Gene

Bridging integrator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for BIN3 Gene

GeneLoc Exon Structure for
BIN3
ECgene alternative splicing isoforms for
BIN3

Expression for BIN3 Gene

mRNA expression in normal human tissues for BIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BIN3 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for BIN3 Gene

This gene is overexpressed in Breast (36.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BIN3 Gene



SOURCE GeneReport for Unigene cluster for BIN3 Gene Hs.433722

mRNA Expression by UniProt/SwissProt for BIN3 Gene

Q9NQY0-BIN3_HUMAN
Tissue specificity: Ubiquitously expressed except in brain.
genes like me logo Genes that share expression patterns with BIN3: view

Protein tissue co-expression partners for BIN3 Gene

Primer Products

Orthologs for BIN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BIN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BIN3 35
  • 89.86 (n)
  • 95.65 (a)
BIN3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIN3 35
  • 90.65 (n)
  • 95.65 (a)
BIN3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bin3 35
  • 87.88 (n)
  • 94.47 (a)
Bin3 16
Bin3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIN3 35
  • 99.34 (n)
  • 100 (a)
BIN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bin3 35
  • 87.62 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
Mammalia BIN3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIN3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIN3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bin3 35
  • 71.43 (n)
  • 78.97 (a)
Str.9914 35
zebrafish
(Danio rerio)
Actinopterygii bin3 35
  • 76.55 (n)
  • 81.82 (a)
bin3 36
  • 79 (a)
OneToMany
BIN3 (2 of 2) 36
  • 84 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER193W 35
  • 49.78 (n)
  • 30.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11903g 35
  • 42 (n)
  • 29.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RVS161 35
  • 40.86 (n)
  • 28.63 (a)
RVS161 36
  • 27 (a)
OneToOne
RVS161 38
bread mold
(Neurospora crassa)
Ascomycetes NCU01069 35
  • 44.88 (n)
  • 31.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hob3 35
  • 44.49 (n)
  • 28.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for BIN3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIN3 Gene

ENSEMBL:
Gene Tree for BIN3 (if available)
TreeFam:
Gene Tree for BIN3 (if available)

Paralogs for BIN3 Gene

(1) SIMAP similar genes for BIN3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BIN3: view

No data available for Paralogs for BIN3 Gene

Variants for BIN3 Gene

Sequence variations from dbSNP and Humsavar for BIN3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2128293 -- 22,631,188(-) gtgca(A/G)ctgct intron-variant
rs2280103 -- 22,668,469(-) ATTCC(A/G)GAGCT intron-variant
rs2280104 -- 22,668,467(-) TCCAG(A/G)GCTAT intron-variant
rs2280105 -- 22,667,653(-) GCTAC(C/T)TTCCC intron-variant
rs2404653 -- 22,625,598(+) GGAAT(A/T)TGGtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BIN3 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv890673 CNV Loss 21882294
esv1623916 CNV Insertion 17803354
esv1939469 CNV Deletion 18987734

Variation tolerance for BIN3 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BIN3 Gene

HapMap Linkage Disequilibrium report
BIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIN3 Gene

Disorders for BIN3 Gene

Relevant External Links for BIN3

Genetic Association Database (GAD)
BIN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIN3

No disorders were found for BIN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIN3 Gene

Publications for BIN3 Gene

  1. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. (PMID: 11274158) Routhier E.L. … Prendergast G.C. (J. Biol. Chem. 2001) 3 4 23 67
  2. The BAR domain proteins: molding membranes in fission, fusion, and phagy. (PMID: 16524918) Ren G. … Munn A.L. (Microbiol. Mol. Biol. Rev. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for BIN3 Gene

Sources for BIN3 Gene

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