Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BIN3 Gene

protein-coding   GIFtS: 53
GCID: GC08M022477

Bridging Integrator 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Bridging Integrator 31 2

External Ids:    HGNC: 10541   Entrez Gene: 559092   Ensembl: ENSG000001474397   OMIM: 6063965   UniProtKB: Q9NQY03   

Export aliases for BIN3 gene to outside databases

Previous GC identifers: GC08P022082 GC08M022831 GC08M022298 GC08M022499 GC08M022533 GC08M021021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BIN3 Gene:
The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of
a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and
induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis,
intracellular transport, and a diverse set of other processes. (provided by RefSeq, Jul 2008)

GeneCards Summary for BIN3 Gene:
BIN3 (bridging integrator 3) is a protein-coding gene. Diseases associated with BIN3 include ornithosis, and pancreatic cancer. GO annotations related to this gene include cytoskeletal adaptor activity.

UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0
Function: Involved in cytokinesis and septation where it has a role in the localization of F-actin

Gene Wiki entry for BIN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BIN3 gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-1   Nkx3-1 v1   Tal-1beta   LCR-F1   E47   Nkx3-1 v2   GATA-6   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BIN3 promoter sequence
   Search Chromatin IP Primers for BIN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.2

BIN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIN3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022477:  view genomic region     (about GC identifiers)

Start:
22,477,931 bp from pter      End:
22,526,661 bp from pter
Size:
48,731 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0 (See protein sequence)
Recommended Name: Bridging integrator 3  
Size: 253 amino acids; 29665 Da
Sequence caution: Sequence=AAH01223.1; Type=Erroneous initiation;
Secondary accessions: Q9BVG2 Q9NVY9
Alternative splicing: 2 isoforms:  Q9NQY0-1   Q9NQY0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BIN3: NX_Q9NQY0

Explore proteomics data for BIN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BIN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061158.1  
    ENSEMBL proteins: 
     ENSP00000276416   ENSP00000430423   ENSP00000382859   ENSP00000430546   ENSP00000429660  
     ENSP00000428768  

    BIN3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BIN3
    OriGene Protein Over-expression Lysate for BIN3
    OriGene MassSpec for BIN3
    OriGene Custom Protein Services for BIN3
    GenScript Custom Purified and Recombinant Proteins Services for BIN3
    Novus Biologicals BIN3 Proteins
    Novus Biologicals BIN3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BIN3

    BIN3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BIN3
    OriGene Custom Antibody Services for BIN3
    Novus Biologicals BIN3 Antibodies
    Abcam antibodies for BIN3
    Cloud-Clone Corp. Antibodies for BIN3
    Search ThermoFisher Antibodies for BIN3
    LSBio Antibodies in human, mouse, rat for BIN3

    BIN3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BIN3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BIN3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BIN3
    Cloud-Clone Corp. CLIAs for BIN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR004148 BAR_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQY0

    ProtoNet protein and cluster: Q9NQY0

    UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0
    Similarity: Contains 1 BAR domain


    BIN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIN3_HUMAN, Q9NQY0
    Function: Involved in cytokinesis and septation where it has a role in the localization of F-actin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18654987
    GO:0008093cytoskeletal adaptor activity NAS11274158
         
    BIN3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BIN3:
     Decreased Hepatitis C virus re  G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bin3):
     hematopoietic system  immune system  liver/biliary system  respiratory system  tumorigenesis 
     vision/eye 

    BIN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bin3tm1Gcp for BIN3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIN3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIN3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIN3:
    hsa-mir-149-5p (MIRT045640), hsa-mir-98-5p (MIRT027575), hsa-let-7d-5p (MIRT032138), hsa-mir-196a-5p (MIRT026045)

    Block miRNA regulation of human, mouse, rat BIN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BIN3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-miR-495 hsa-let-7d hsa-let-7c hsa-miR-4282 hsa-let-7i hsa-miR-184
    SwitchGear 3'UTR luciferase reporter plasmidBIN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BIN3
    Predesigned siRNA for gene silencing in human, mouse, rat BIN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BIN3

    Clone
    Products:
         
    OriGene clones in human, mouse for BIN3 (see all 6)
    OriGene ORF clones in mouse, rat for BIN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIN3 (NM_018688)
    Sino Biological Human cDNA Clone for BIN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BIN3
    Browse ESI BIO Cell Lines and PureStem Progenitors for BIN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BIN3_HUMAN, Q9NQY0: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    BIN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BIN3
    Interactions:

        Search GeneGlobe Interaction Network for BIN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIN3 (Q9NQY01, 3 ENSP000002764164) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNMBPQ6XZF71, 3, ENSP000003156594EBI-2653038,EBI-2483419 I2D: score=1 STRING: ENSP00000315659
    ERHP840903I2D: score=1 
    COA4ENSP000003479194STRING: ENSP00000347919
    MTRRENSP000002646684STRING: ENSP00000264668
    PFDN2ENSP000003569894STRING: ENSP00000356989
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS11274158
    GO:0000917barrier septum assembly IEA--
    GO:0007015actin filament organization NAS11274158
    GO:0008104protein localization IMP11274158
    GO:0009826unidimensional cell growth IMP11274158

    BIN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BIN3 gene: 
    NM_018688.4  

    Unigene Cluster for BIN3:

    Bridging integrator 3
    Hs.433722  [show with all ESTs]
    Unigene Representative Sequence: BC050314
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276416(uc003xcl.3 uc010ltw.3) ENST00000520489 ENST00000519513
    ENST00000399977 ENST00000519335 ENST00000519863 ENST00000522687 ENST00000520292
    ENST00000521140 ENST00000518366 ENST00000522268
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BIN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BIN3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-miR-495 hsa-let-7d hsa-let-7c hsa-miR-4282 hsa-let-7i hsa-miR-184
    SwitchGear 3'UTR luciferase reporter plasmidBIN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BIN3
    Predesigned siRNA for gene silencing in human, mouse, rat BIN3
    Clone
    Products:
         
    OriGene clones in human, mouse for BIN3 (see all 6)
    OriGene ORF clones in mouse, rat for BIN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIN3 (NM_018688)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BIN3
    OriGene qSTAR qPCR primer pairs in human, mouse for BIN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIN3
      QuantiTect SYBR Green Assays in human, mouse, rat BIN3
      QuantiFast Probe-based Assays in human, mouse, rat BIN3

    Additional mRNA sequence: 

    AF271732.1 AK001289.1 AK023980.1 AK124486.1 AK222470.1 BC001223.1 BC009824.2 BC050314.1 

    17 DOTS entries:

    DT.454185  DT.91738811  DT.100848059  DT.307907  DT.100028655  DT.40114938  DT.121471422  DT.121471418 
    DT.91969078  DT.92016419  DT.95104538  DT.95137166  DT.97800537  DT.97845467  DT.100867432  DT.121471393 
    DT.95257484 

    Selected AceView cDNA sequences (see all 278):

    BM763599 AA744592 BE550579 CR626268 BU630453 CR620938 F07620 CD244345 
    AK001289 AI417058 CR612252 AI581845 CR619792 CR600556 AI650541 CR611814 
    BQ938840 AI358211 CB115901 BM830582 AF271732 Z43219 BF726984 Z39295 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BIN3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                      -           -                 -     -                                                               
    SP2:                                      -           -                 -     -                             -     -                           
    SP3:                                      -           -                 -     -                                                               
    SP4:                                      -     -     -                 -     -                             -     -                           
    SP5:                                      -                             -     -                                                               


    ECgene alternative splicing isoforms for BIN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BIN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTGTGGGC
    BIN3 Expression
    About this image


    BIN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    BIN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433722

    UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0
    Tissue specificity: Ubiquitously expressed except in brain

        Custom PCR Arrays for BIN3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BIN3
    OriGene qSTAR qPCR primer pairs in human, mouse for BIN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIN3
    QuantiTect SYBR Green Assays in human, mouse, rat BIN3
    QuantiFast Probe-based Assays in human, mouse, rat BIN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BIN3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bin31 , 5 bridging integrator 31, 5 87.88(n)1
    94.47(a)1
      14 (36.21 cM)5
    577841  NM_021328.31  NP_067303.11 
     701001455 
    lizard
    (Anolis carolinensis)
    Reptilia BIN36
    bridging integrator 3
    86(a)
    1 ↔ 1
    GL343443.1(591835-647059)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.99142 Transcribed sequence with moderate similarity to protein more 75.9(n)    CF378560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bin31 bridging integrator 3 76.55(n)
    81.82(a)
      323976  NM_001123044.1  NP_001116516.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RVS161(YCR009C)4
    RVS1611
    Amphiphysin-like lipid raft protein; interacts with more4
    RVS1611
    40.86(n)1
    28.63(a)1
      3(131542-130745)4
    8503671, 4  NP_009935.11, 4 


    ENSEMBL Gene Tree for BIN3 (if available)
    TreeFam Gene Tree for BIN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BIN3 gene
    1 SIMAP similar gene for BIN3 using alignment to 6 protein entries:     BIN3_HUMAN (see all proteins):
    FLJ00367

    BIN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BIN3 (see all 1143)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774510211,2
    F--22478489(+) GTTCAG/TGGCCT 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1412498141,2
    C--22478545(+) AGAGGG/TCTCCC 1 -- ut310--------
    rs1449621941,2
    --22478590(+) ACAACA/GCATGC 1 -- ut310--------
    rs70009931,2
    C,F--22478591(+) CAACGC/TATGCA 1 -- ut31 ese31Minor allele frequency- T:0.08WA 118
    rs70084291,2
    C,F,A--22478592(+) AACGCA/GTGCAA 1 -- ut31 ese37Minor allele frequency- G:0.18NA WA EA 382
    rs1380987241,2
    C--22478663(+) AGGCCA/GTGGGC 1 -- ut310--------
    rs70010411,2
    C,F--22478685(+) CTGGAC/TGGTTC 1 -- ut31 ese34Minor allele frequency- T:0.03NA WA 260
    rs2020372711,2
    --22478792(+) CTCAG-/GAAGAGTC 1 -- cds10--------
    rs1839287891,2
    --22478816(+) AGGGCC/TGGCAA 1 -- ut310--------
    rs1147382441,2
    C,F--22478817(+) GGGCCG/AGCAAG 1 -- ut311Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for BIN3 (22477931 - 22526661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BIN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1939469CNV Deletion18987734
    esv1623916CNV Insertion17803354
    nsv890673CNV Loss21882294
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIN3
    DNA2.0 Custom Variant and Variant Library Synthesis for BIN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606396    OMIM disorders: --

    3 diseases for BIN3:    
    About MalaCards
    ornithosis    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for BIN3:
    Ornithosis

    BIN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BIN3

    Export disorders for BIN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BIN3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with BIN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. (PubMed id 11274158)1, 2, 9 Routhier E.L....Prendergast G.C. (J. Biol. Chem. 2001)
    2. The BAR domain proteins: molding membranes in fission, fusion, and phagy. (PubMed id 16524918)1, 3 Ren G....Munn A.L. (Microbiol. Mol. Biol. Rev. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (Proteomics 2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55909 HGNC: 1054 AceView: BIN3 Ensembl:ENSG00000147439 euGenes: HUgn55909
    ECgene: BIN3 H-InvDB: BIN3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BIN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BIN3 gene:
    Search GeneIP for patents involving BIN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BIN3   OriGene RNAi products in human, mouse, rat for BIN3  
     OriGene qPCR primer pairs and template standards for BIN3   OriGene Protein Over-expression Lysate for BIN3  
     OriGene MassSpec something-or-other for BIN3   OriGene clones in human, mouse for BIN3  
     OriGene qSTAR qPCR primer pairs in human, mouse for BIN3   OriGene Purified Protein for BIN3  
     OriGene ORF clones in mouse, rat for BIN3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BIN3   OriGene Custom Protein Services for BIN3  

     
     
     Block miRNA regulation of human, mouse, rat BIN3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BIN3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIN3 Predesigned siRNA for gene silencing in human, mouse, rat BIN3
     QuantiFast Probe-based Assays in human, mouse, rat BIN3 QuantiTect SYBR Green Assays in human, mouse, rat BIN3
     Custom PCR Arrays for BIN3 Search Chromatin IP Primers for BIN3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIN3  Search GeneGlobe Interaction Network for BIN3
     Regulatory tfbs in BIN3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BIN3 GenScript cDNA clones with any tag delivered in your preferred vector for BIN3
     GenScript Custom Assay Services for BIN3 GenScript Custom overexpressing Cell Line Services for BIN3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BIN3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BIN3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BIN3 antibodies
     BIN3 proteins
     BIN3 lysates
     Antibodies for BIN3
     See all of Abcam's Antibodies, Kits and Proteins for BIN3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BIN3
     Antibodies for BIN3
     ELISAs for BIN3
     CLIAs for BIN3



     Browse ESI BIO Cell Lines and PureStem Progenitors for BIN3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN3
     SwitchGear 3'UTR luciferase reporter plasmids for BIN3
     SwitchGear Promoter luciferase reporter plasmids for BIN3
     Search ThermoFisher Antibodies for BIN3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIN3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIN3
     LSBio Antibodies in human, mouse, rat for BIN3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BIN3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4