BIN3 Gene
protein-coding GIFtS: 50
GCID: GC08M022477
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|
bridging integrator 3
| |
Aliases
for BIN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Bridging Integrator 31 2 |
Export aliases for BIN3 gene to outside databasesPrevious GC identifers: GC08P022082 GC08M022831 GC08M022298 GC08M022499 GC08M022533 GC08M021021 |
Summaries
for BIN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BIN3:
The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BARdomain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and inducemembrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellulartransport, and a diverse set of other processes. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Function: Involved in cytokinesis and septation where it has a role in the localization of F-actin
Gene Wiki entry for BIN3
|
Genomic Views
for BIN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BIN3 gene promoter:
Nkx3-1 Nkx3-1 v4 AP-1 Nkx3-1 v1 Tal-1beta LCR-F1 E47 Nkx3-1 v2 GATA-6 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for BIN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.3 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.2BIN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M022477: view genomic region
(about GC identifiers)
Start:
|
22,477,931 bp from pter |
End:
|
22,526,661 bp from pter |
Size:
|
48,731 bases |
Orientation:
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minus strand |
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Proteins
for BIN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0 (See
protein sequence)Recommended Name: Bridging integrator 3 Size: 253 amino acids; 29665 Da
Subcellular location: Cytoplasm, cytoskeleton
Sequence caution: Sequence=AAH01223.1; Type=Erroneous initiation;
Secondary accessions: Q9BVG2 Q9NVY9Alternative splicing: 2 isoforms: Q9NQY0-1 Q9NQY0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BIN3: NX_Q9NQY0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQY0
BIN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061158.1
ENSEMBL proteins: ENSP00000276416 ENSP00000430423 ENSP00000382859 ENSP00000430546 ENSP00000429660 ENSP00000428768
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
BIN3 for ontologies About GeneDecksing
BIN3 Antibody Products:
Assay Products for BIN3: |
Protein
Domains /
Families
for BIN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BIN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NQY0ProtoNet protein and cluster: Q9NQY0 UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Similarity: Contains 1 BAR domain |
Function
for BIN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Function: Involved in cytokinesis and septation where it has a role in the localization of F-actin
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BIN3 (NM_018688) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
BIN3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for BIN3:
Animal Models:
Mouse knock-out Bin3tm1Gcp for BIN3
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bin3):
BIN3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BIN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BIN3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/23 Interacting proteins for BIN3 (Q9NQY01, 3 ENSP000002764164) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
BIN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for BIN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BIN3
Search CenterWatch for drugs/clinical trials and news about BIN3
|
Transcripts
for BIN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BIN3 gene: NM_018688.4 Unigene Cluster for BIN3: Bridging integrator 3 Hs.654720 [show with all ESTs]Unigene Representative Sequence: BC05031411 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276416(uc003xcl.3 uc010ltw.3) ENST00000520489 ENST00000519513
ENST00000399977 ENST00000519335 ENST00000519863 ENST00000522687 ENST00000520292
ENST00000521140 ENST00000518366 ENST00000522268
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BIN3 (NM_018688) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN3 |
Additional cDNA sequence: AF271732.1 AK001289.1 AK023980.1 AK124486.1 AK222470.1 BC001223.1 BC009824.2 BC050314.1 15 DOTS entries: DT.454185 DT.91738811 DT.100848059 DT.307907 DT.100028655 DT.40114938 DT.121471422 DT.121471418 DT.91969078 DT.92016419 DT.95104538 DT.95137166 DT.97845467 DT.121471393 DT.97800537 24/278 AceView cDNA sequences (see all 278): BU628962 BU634482 BQ016153 CD244345 BU630453 BU185630 AK124486 AI498450 Z39295 BF726984 AL542046 BE740418 AW772308 BQ938840 AA744592 CR623018 BF850372 BE796954 BC001223 F03866 AK023980 AW237835 F07620 BQ679827
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BIN3 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BIN3
|
Expression
for BIN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BIN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTTGTGGGC
About this image
See BIN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BIN3
SOURCE GeneReport for Unigene cluster: Hs.654720
UniProtKB/Swiss-Prot: BIN3_HUMAN, Q9NQY0Tissue specificity: Ubiquitously expressed except in brain
SABiosciences Custom PCR Arrays for BIN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN3 |
Orthologs
for BIN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for BIN3 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for BIN3 (if available)
TreeFam Gene Tree for BIN3 (if available) |
Paralogs
for BIN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BIN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BIN3 (22477931 - 22526661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BIN3
2 CNVs: 2746 3726 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIN3 |
|
Disorders
/ Diseases
for BIN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BIN3 for disorders About GeneDecksing
OMIM gene information: 606396
OMIM disorders: --
3  diseases for BIN3: About MalaCardsornithosis pancreatic cancer pancreatitis
1 disease from the University of Copenhagen DISEASES database for BIN3:Ornithosis Export disorders for BIN3 gene to outside databases
|
Publications
for BIN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BIN3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with BIN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. (PubMed id 11274158)1, 2, 9 Routhier E.L....Prendergast G.C. (2001)
- The BAR domain proteins: molding membranes in fission, fusion, and phagy. (PubMed id 16524918)1, 3 Ren G....Munn A.L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for BIN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BIN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BIN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BIN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BIN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BIN3 gene:
Search GeneIP for patents involving BIN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BIN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BIN3 | | OriGene shRNA RFP for BIN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIN3 | | | OriGene Protein Over-expression Lysate for BIN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BIN3 | | OriGene 3'-UTR Clone for BIN3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BIN3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BIN3 | | OriGene Custom Protein Services for BIN3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BIN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIN3 |
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 | | | BIN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN3 |
|  |  |  | | | | Search ThermoFisher Antibodies for BIN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN3 |
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