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Aliases for BIN3 Gene

Aliases for BIN3 Gene

  • Bridging Integrator 3 2 3

External Ids for BIN3 Gene

Previous GeneCards Identifiers for BIN3 Gene

  • GC08P022082
  • GC08M022831
  • GC08M022298
  • GC08M022499
  • GC08M022533
  • GC08M021021
  • GC08M022477

Summaries for BIN3 Gene

Entrez Gene Summary for BIN3 Gene

  • The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for BIN3 Gene

BIN3 (Bridging Integrator 3) is a Protein Coding gene. Diseases associated with BIN3 include ornithosis. GO annotations related to this gene include cytoskeletal adaptor activity.

UniProtKB/Swiss-Prot for BIN3 Gene

  • Involved in cytokinesis and septation where it has a role in the localization of F-actin

Gene Wiki entry for BIN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIN3 Gene

Genomics for BIN3 Gene

Regulatory Elements for BIN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BIN3 Gene

Start:
22,620,418 bp from pter
End:
22,669,148 bp from pter
Size:
48,731 bases
Orientation:
Minus strand

Genomic View for BIN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIN3 Gene

Proteins for BIN3 Gene

  • Protein details for BIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQY0-BIN3_HUMAN
    Recommended name:
    Bridging integrator 3
    Protein Accession:
    Q9NQY0
    Secondary Accessions:
    • Q9BVG2
    • Q9NVY9

    Protein attributes for BIN3 Gene

    Size:
    253 amino acids
    Molecular mass:
    29665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01223.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIN3 Gene

Proteomics data for BIN3 Gene at MOPED

Post-translational modifications for BIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIN3 Gene

No data available for DME Specific Peptides for BIN3 Gene

Domains for BIN3 Gene

Protein Domains for BIN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BIN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQY0

UniProtKB/Swiss-Prot:

BIN3_HUMAN :
  • Q9NQY0
Domain:
  • Contains 1 BAR domain.
genes like me logo Genes that share domains with BIN3: view

No data available for Gene Families for BIN3 Gene

Function for BIN3 Gene

Molecular function for BIN3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cytokinesis and septation where it has a role in the localization of F-actin

Gene Ontology (GO) - Molecular Function for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18654987
GO:0008093 cytoskeletal adaptor activity NAS 11274158
genes like me logo Genes that share ontologies with BIN3: view
genes like me logo Genes that share phenotypes with BIN3: view

Animal Models for BIN3 Gene

MGI Knock Outs for BIN3:

Animal Model Products

miRNA for BIN3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BIN3 Gene

Localization for BIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIN3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIN3 Gene COMPARTMENTS Subcellular localization image for BIN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with BIN3: view

Pathways for BIN3 Gene

SuperPathways for BIN3 Gene

No Data Available

Interacting Proteins for BIN3 Gene

Gene Ontology (GO) - Biological Process for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 11274158
GO:0000917 barrier septum assembly IEA --
GO:0007015 actin filament organization NAS 11274158
GO:0008104 protein localization IMP 11274158
GO:0009826 unidimensional cell growth IMP 11274158
genes like me logo Genes that share ontologies with BIN3: view

No data available for Pathways by source for BIN3 Gene

Transcripts for BIN3 Gene

Unigene Clusters for BIN3 Gene

Bridging integrator 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BIN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for BIN3 Gene

GeneLoc Exon Structure for
BIN3
ECgene alternative splicing isoforms for
BIN3

Expression for BIN3 Gene

mRNA expression in normal human tissues for BIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BIN3 Gene

This gene is overexpressed in Whole Blood (4.8).

Protein differential expression in normal tissues for BIN3 Gene

This gene is overexpressed in Breast (36.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIN3 Gene

SOURCE GeneReport for Unigene cluster for BIN3 Gene Hs.433722

mRNA Expression by UniProt/SwissProt for BIN3 Gene

Q9NQY0-BIN3_HUMAN
Tissue specificity: Ubiquitously expressed except in brain.
genes like me logo Genes that share expressions with BIN3: view

Expression partners for BIN3 Gene

In Situ Assay Products

Orthologs for BIN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BIN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BIN3 35
  • 89.86 (n)
  • 95.65 (a)
BIN3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIN3 35
  • 90.65 (n)
  • 95.65 (a)
BIN3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bin3 35
  • 87.88 (n)
  • 94.47 (a)
Bin3 16
Bin3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIN3 35
  • 99.34 (n)
  • 100 (a)
BIN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bin3 35
  • 87.62 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
Mammalia BIN3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIN3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIN3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bin3 35
  • 71.43 (n)
  • 78.97 (a)
Str.9914 35
zebrafish
(Danio rerio)
Actinopterygii bin3 35
  • 76.55 (n)
  • 81.82 (a)
bin3 36
  • 79 (a)
OneToMany
BIN3 (2 of 2) 36
  • 84 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER193W 35
  • 49.78 (n)
  • 30.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11903g 35
  • 42 (n)
  • 29.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RVS161 35
  • 40.86 (n)
  • 28.63 (a)
RVS161 36
  • 27 (a)
OneToOne
RVS161 38
bread mold
(Neurospora crassa)
Ascomycetes NCU01069 35
  • 44.88 (n)
  • 31.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hob3 35
  • 44.49 (n)
  • 28.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for BIN3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIN3 Gene

ENSEMBL:
Gene Tree for BIN3 (if available)
TreeFam:
Gene Tree for BIN3 (if available)

Paralogs for BIN3 Gene

Selected SIMAP similar genes for BIN3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BIN3: view

No data available for Paralogs for BIN3 Gene

Variants for BIN3 Gene

Sequence variations from dbSNP and Humsavar for BIN3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs749366 -- 22,644,215(-) TAGAA(A/T)GTTTT intron-variant
rs754787 -- 22,636,896(-) GATGA(A/G)GTGGG intron-variant
rs868461 -- 22,670,198(+) CTCAC(A/C/T)GCTAA upstream-variant-2KB
rs876713 -- 22,625,215(+) ATGTG(G/T)CCTCT intron-variant
rs876714 -- 22,625,286(+) GGTGC(A/G)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BIN3 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv890673 CNV Loss 21882294
esv1623916 CNV Insertion 17803354
esv1939469 CNV Deletion 18987734

Relevant External Links for BIN3 Gene

HapMap Linkage Disequilibrium report
BIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIN3 Gene

Disorders for BIN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BIN3 Gene in MalaCards »

(1) Diseases for BIN3 Gene including...

(1) University of Copenhagen DISEASES for BIN3 Gene

Relevant External Links for BIN3

Genetic Association Database (GAD)
BIN3
genes like me logo Genes that share disorders with BIN3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for BIN3 Gene

Publications for BIN3 Gene

  1. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. (PMID: 11274158) Routhier E.L. … Prendergast G.C. (J. Biol. Chem. 2001) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The BAR domain proteins: molding membranes in fission, fusion, and phagy. (PMID: 16524918) Ren G. … Munn A.L. (Microbiol. Mol. Biol. Rev. 2006) 2 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for BIN3 Gene

Sources for BIN3 Gene

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