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BIN2 Gene

protein-coding   GIFtS: 53
GCID: GC12M051674

Bridging Integrator 2

  See BIN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bridging Integrator 21 2
Breast Cancer-Associated Protein 12 3
BRAP-12
Breast Cancer Associated Protein BRAP12
Bridging Integrator-22
BRAP13

External Ids:    HGNC: 10531   Entrez Gene: 514112   Ensembl: ENSG000001109347   OMIM: 6059365   UniProtKB: Q9UBW53   

Export aliases for BIN2 gene to outside databases

Previous GC identifers: GC12M051831 GC12M051697 GC12M051391 GC12M049961 GC12M048707


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BIN2 Gene:
BIN2 (bridging integrator 2) is a protein-coding gene. Diseases associated with BIN2 include epididymo-orchitis, and orchitis. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is BIN1.

UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5
Function: Promotes cell motility and migration, probably via its interaction with the cell membrane and with
podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates
membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BIN2 gene promoter:
         c-Fos   AP-1   AML1a   Tal-1   HNF-4alpha2   HNF-4alpha1   E47   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBIN2 promoter sequence
   Search Chromatin IP Primers for BIN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

BIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIN2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051674:  view genomic region     (about GC identifiers)

Start:
51,674,822 bp from pter      End:
51,718,452 bp from pter
Size:
43,631 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5 (See protein sequence)
Recommended Name: Bridging integrator 2  
Size: 565 amino acids; 61874 Da
Subunit: Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain),
SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2
Sequence caution: Sequence=BAA91376.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91376.1; Type=Frameshift; Positions=156;
2 PDB 3D structures from and Proteopedia for BIN2:
4AVM (3D)        4I1Q (3D)    
Secondary accessions: Q86VV0 Q9NWK4 Q9UKN4
Alternative splicing: 2 isoforms:  Q9UBW5-1   Q9UBW5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BIN2: NX_Q9UBW5

Explore proteomics data for BIN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65
  • Modification sites at PhosphoSitePlus

  • See BIN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001276936.1  NP_001276937.1  NP_001276938.1  NP_057377.3  

    ENSEMBL proteins: 
     ENSP00000474972   ENSP00000410217   ENSP00000267012   ENSP00000445874   ENSP00000474425  

    BIN2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for BIN2

     
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    Cloud-Clone Corp. ELISAs for BIN2
    Cloud-Clone Corp. CLIAs for BIN2
    Search eBioscience for ELISAs for BIN2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR003005 Amphiphysin
     IPR028827 BIN2
     IPR004148 BAR_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBW5

    ProtoNet protein and cluster: Q9UBW5

    UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5
    Domain: The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides
    Similarity: Contains 1 BAR domain


    Find genes that share domains with BIN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIN2_HUMAN, Q9UBW5
    Function: Promotes cell motility and migration, probably via its interaction with the cell membrane and with
    podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates
    membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis
    Induction: Up-regulated during monocytic differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10903846
    GO:0005543phospholipid binding IDA--
         
    Find genes that share ontologies with BIN2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BIN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BIN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIN2
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    7 qRT-PCR Assays for microRNAs that regulate BIN2:
    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-4268 hsa-miR-1264 hsa-miR-3647-3p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidBIN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BIN2

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    GenScript: all cDNA clones in your preferred vector: BIN2 (NM_016293)
    Sino Biological Human cDNA Clone for BIN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BIN2_HUMAN, Q9UBW5: Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic
    side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in
    phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at
    podosomes, at an actin-rich ring-like structure
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    nucleus3
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891colocalizes with phagocytic cup IDA--
    GO:0002102podosome IDA--
    GO:0005737cytoplasm ----
    GO:0005938cell cortex IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with BIN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BIN2
    Interactions:

        Search GeneGlobe Interaction Network for BIN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BIN2 (Q9UBW51, 3 ENSP000002670124) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BIN1O004991, 3, ENSP000003167794EBI-2042570,EBI-719094 I2D: score=1 STRING: ENSP00000316779
    MYO1FENSP000003448714STRING: ENSP00000344871
    EXOC4ENSP000002538614STRING: ENSP00000253861
    PFDN2ENSP000003569894STRING: ENSP00000356989
    WASENSP000003658914STRING: ENSP00000365891
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006911phagocytosis, engulfment IMP--
    GO:0060326cell chemotaxis IMP--
    GO:0071800podosome assembly IMP--
    GO:0097320membrane tubulation IDA--

    Find genes that share ontologies with BIN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BIN2 gene (4 alternative transcripts): 
    NM_001290007.1  NM_001290008.1  NM_001290009.1  NM_016293.3  

    Unigene Cluster for BIN2:

    Bridging integrator 2
    Hs.14770  [show with all ESTs]
    Unigene Representative Sequence: AK225911
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604560 ENST00000605039 ENST00000452142(uc009zlz.3) ENST00000267012(uc001ryg.3 uc001ryh.3 uc010sng.2)
    ENST00000544402 ENST00000603177 ENST00000605819 ENST00000605423 ENST00000603260
    ENST00000604702
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate BIN2:
    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-4268 hsa-miR-1264 hsa-miR-3647-3p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidBIN2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIN2 (NM_016293)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIN2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIN2
      QuantiTect SYBR Green Assays in human, mouse, rat BIN2
      QuantiFast Probe-based Assays in human, mouse, rat BIN2

    Additional mRNA sequence: 

    AB032698.1 AF146531.1 AK000783.1 AK093638.1 AK225911.1 AK300211.1 AK314304.1 BC047686.1 

    8 DOTS entries:

    DT.213694  DT.92423269  DT.40123682  DT.95147399  DT.95265026  DT.100712927  DT.91647061  DT.92423270 

    Selected AceView cDNA sequences (see all 120):

    BX281612 AA988660 BU753979 AW118269 AI052200 BG388638 AA776278 AI247125 
    NM_016293 AA678263 BQ018830 AW440832 AA743030 AK093638 BE466294 AW768285 
    BE222586 AA465503 T80782 AI538476 BX456768 AA746203 CB992843 AA987798 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BIN2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                          -                       -                                                               
    SP2:                          -                       -     -                                                         
    SP3:                          -                                                                                       
    SP4:                          -                                                                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for BIN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BIN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCAGAAA
    BIN2 Expression
    About this image


    BIN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Placenta (Extraembryonic Tissues)
     
     Spleen (Hematopoietic System)
    BIN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14770

    UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5
    Tissue specificity: Detected in natural killer cells (at protein level). Highest level expression seen in spleen
    and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting
    preferential expression in hematopoietic tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BIN2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bin21 , 5 bridging integrator 21, 5 77.3(n)1
    74.14(a)1
      15 (56.37 cM)5
    6682181  NM_001270537.11  NP_001257466.11 
     1006410815 
    chicken
    (Gallus gallus)
    Aves BIN26
    bridging integrator 2
    25(a)
    1 ↔ 1
    JH375734.1(2113-6133)
    lizard
    (Anolis carolinensis)
    Reptilia BIN26
    bridging integrator 2
    70(a)
    1 ↔ 1
    2(67617059-67691641)
    zebrafish
    (Danio rerio)
    Actinopterygii BC044473.12   -- 75.33(n)   327387  BC044473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Amph3 NOT synaptic vesicle endocytosis 36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F58G6.13 amphiphysin like 38(a)   IV(9644867-9647871)   --


    ENSEMBL Gene Tree for BIN2 (if available)
    TreeFam Gene Tree for BIN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BIN2 gene
    BIN12  AMPH2  
    2 SIMAP similar genes for BIN2 using alignment to 4 protein entries:     BIN2_HUMAN (see all proteins):
    AMPH    BIN1

    Find genes that share paralogs with BIN2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for BIN2
    PGOHUM00000245980 PGOHUM00000235280 PGOHUM00000235657


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BIN2 (see all 1002)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491555641,2
    --51674384(+) TCCCAA/GCCTCA 1 -- int10--------
    rs1432784711,2
    --51674393(+) CAGGCA/GATCCA 1 -- int10--------
    rs1816492081,2
    --51674409(+) CTCGGA/CCTCCC 1 -- int10--------
    rs1855393291,2
    --51674455(+) CAGCCA/GATATG 1 -- int10--------
    rs47619811,2
    C,F,A,H--51674501(+) ATATCC/TTCCTC 1 -- int133Minor allele frequency- T:0.44NS EA NA WA CSA 3202
    rs1902517411,2
    --51674526(+) CCTTAA/CTCATA 1 -- int10--------
    rs1483339441,2
    C--51674551(+) GTAAAC/TACCAG 1 -- int10--------
    rs1828462171,2
    --51674572(+) AAAATA/GTTATT 1 -- int10--------
    rs1867610471,2
    --51674628(+) GGAGCA/GCATGC 1 -- int10--------
    rs785146881,2
    C,F--51674652(+) AGAGTC/GTGTGG 1 -- int13Minor allele frequency- G:0.06WA NA EA 358

    HapMap Linkage Disequilibrium report for BIN2 (51674822 - 51718452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BIN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469377CNV Loss19166990
    nsv832408CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIN2
    DNA2.0 Custom Variant and Variant Library Synthesis for BIN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605936    OMIM disorders: --

    3 diseases for BIN2:    
    About MalaCards
    epididymo-orchitis    orchitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BIN2:
    epididymo-orchitis

    Find genes that share disorders with BIN2           About GenesLikeMe

    Genetic Association Database (GAD): BIN2
    Human Genome Epidemiology (HuGE) Navigator: BIN2 (1 document)

    Export disorders for BIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BIN2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with BIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bin2, a functionally nonredundant member of the BAR adaptor gene family. (PubMed id 10903846)1, 2, 3 Ge K. and Prendergast G.C. (Genomics 2000)
    2. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PubMed id 23285027)1, 2 Sanchez-Barrena M.J.... McMahon H.T. (PLoS ONE 2012)
    3. A genome-wide association study of aging. (PubMed id 21782286)1, 4 Walter S....Franceschini N. (Neurobiol. Aging 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51411 HGNC: 1053 AceView: BIN2 Ensembl:ENSG00000110934 euGenes: HUgn51411
    ECgene: BIN2 H-InvDB: BIN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BIN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BIN2 gene:
    Search GeneIP for patents involving BIN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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