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Aliases for BIN2 Gene

Aliases for BIN2 Gene

  • Bridging Integrator 2 2 3 5
  • Breast Cancer-Associated Protein 1 3 4
  • Breast Cancer Associated Protein BRAP1 3
  • Bridging Integrator-2 3
  • BRAP-1 3
  • BRAP1 4

External Ids for BIN2 Gene

Previous GeneCards Identifiers for BIN2 Gene

  • GC12M051831
  • GC12M051697
  • GC12M051391
  • GC12M049961
  • GC12M048707
  • GC12M051674

Summaries for BIN2 Gene

GeneCards Summary for BIN2 Gene

BIN2 (Bridging Integrator 2) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is BIN1.

UniProtKB/Swiss-Prot for BIN2 Gene

  • Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIN2 Gene

Genomics for BIN2 Gene

Regulatory Elements for BIN2 Gene

Enhancers for BIN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BIN2 on UCSC Golden Path with GeneCards custom track

Promoters for BIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BIN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BIN2 Gene

Chromosome:
12
Start:
51,281,038 bp from pter
End:
51,324,680 bp from pter
Size:
43,643 bases
Orientation:
Minus strand

Genomic View for BIN2 Gene

Genes around BIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIN2 Gene

Proteins for BIN2 Gene

  • Protein details for BIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW5-BIN2_HUMAN
    Recommended name:
    Bridging integrator 2
    Protein Accession:
    Q9UBW5
    Secondary Accessions:
    • Q86VV0
    • Q9NWK4
    • Q9UKN4

    Protein attributes for BIN2 Gene

    Size:
    565 amino acids
    Molecular mass:
    61874 Da
    Quaternary structure:
    • Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2.
    SequenceCaution:
    • Sequence=BAA91376.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91376.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BIN2 Gene

    Alternative splice isoforms for BIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIN2 Gene

Proteomics data for BIN2 Gene at MOPED

Post-translational modifications for BIN2 Gene

  • Ubiquitination at Lys 65
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BIN2 Gene

Domains & Families for BIN2 Gene

Protein Domains for BIN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBW5

UniProtKB/Swiss-Prot:

BIN2_HUMAN :
  • The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
Domain:
  • The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
  • Contains 1 BAR domain.
genes like me logo Genes that share domains with BIN2: view

No data available for Gene Families for BIN2 Gene

Function for BIN2 Gene

Molecular function for BIN2 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated during monocytic differentiation.

Phenotypes for BIN2 Gene

genes like me logo Genes that share phenotypes with BIN2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BIN2 Gene

Localization for BIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIN2 Gene

Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000269 PubMed:23285027}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIN2 Gene COMPARTMENTS Subcellular localization image for BIN2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 colocalizes_with phagocytic cup IDA 23285027
genes like me logo Genes that share ontologies with BIN2: view

Pathways & Interactions for BIN2 Gene

SuperPathways for BIN2 Gene

No Data Available

Interacting Proteins for BIN2 Gene

Selected Interacting proteins: Q9UBW5-BIN2_HUMAN for BIN2 Gene via UniProtKB I2D

Symbol External ID(s) Details
BIN1

Gene Ontology (GO) - Biological Process for BIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071800 podosome assembly IMP 23285027
genes like me logo Genes that share ontologies with BIN2: view

No data available for Pathways by source and SIGNOR curated interactions for BIN2 Gene

Drugs & Compounds for BIN2 Gene

No Compound Related Data Available

Transcripts for BIN2 Gene

Unigene Clusters for BIN2 Gene

Bridging integrator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for BIN2 Gene

GeneLoc Exon Structure for
BIN2
ECgene alternative splicing isoforms for
BIN2

Expression for BIN2 Gene

mRNA expression in normal human tissues for BIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BIN2 Gene

This gene is overexpressed in Whole Blood (x36.3).

Protein differential expression in normal tissues from HIPED for BIN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.4), Platelet (19.2), and Lavage (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BIN2 Gene



SOURCE GeneReport for Unigene cluster for BIN2 Gene Hs.14770

mRNA Expression by UniProt/SwissProt for BIN2 Gene

Q9UBW5-BIN2_HUMAN
Tissue specificity: Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
genes like me logo Genes that share expression patterns with BIN2: view

Protein tissue co-expression partners for BIN2 Gene

- Elite partner

Primer Products

Orthologs for BIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BIN2 35
  • 84.81 (n)
  • 82.05 (a)
BIN2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIN2 35
  • 85.83 (n)
  • 82.44 (a)
BIN2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bin2 35
  • 77.3 (n)
  • 74.14 (a)
Bin2 16
Bin2 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BIN2 35
  • 98.38 (n)
  • 97.47 (a)
BIN2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bin2 35
  • 76.24 (n)
  • 72.13 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia BIN2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves BIN2 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIN2 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
bin2a 36
  • 34 (a)
OneToMany
bin2b 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Amph 37
  • 36 (a)
Amph 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F58G6.1 37
  • 38 (a)
amph-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3172 36
  • 19 (a)
OneToMany
Species with no ortholog for BIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BIN2 Gene

ENSEMBL:
Gene Tree for BIN2 (if available)
TreeFam:
Gene Tree for BIN2 (if available)

Paralogs for BIN2 Gene

Paralogs for BIN2 Gene

(2) SIMAP similar genes for BIN2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for BIN2 Gene

genes like me logo Genes that share paralogs with BIN2: view

Variants for BIN2 Gene

Sequence variations from dbSNP and Humsavar for BIN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7312857 - 51,313,842(+) AGTTG(C/T)TAGCG reference, missense, utr-variant-5-prime
rs7954976 - 51,288,119(+) GGAGT(C/T)AGCTG intron-variant, reference, missense
rs1965075 -- 51,293,546(+) tgacc(C/T)cgtga intron-variant
rs1991433 -- 51,290,191(+) GTCGG(C/T)TTACT intron-variant
rs2011124 -- 51,304,986(+) GTACT(C/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BIN2 Gene

Variant ID Type Subtype PubMed ID
nsv469377 CNV Loss 19166990
nsv832408 CNV Gain 17160897

Variation tolerance for BIN2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BIN2 Gene

Disorders for BIN2 Gene

Relevant External Links for BIN2

Genetic Association Database (GAD)
BIN2
Human Genome Epidemiology (HuGE) Navigator
BIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIN2

No disorders were found for BIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIN2 Gene

Publications for BIN2 Gene

  1. Bin2, a functionally nonredundant member of the BAR adaptor gene family. (PMID: 10903846) Ge K. … Prendergast G.C. (Genomics 2000) 2 3 4 67
  2. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PMID: 23285027) Sanchez-Barrena M.J. … McMahon H.T. (PLoS ONE 2012) 3
  3. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3
  4. A genome-wide association study of aging. (PMID: 21782286) Walter S. … Franceschini N. (Neurobiol. Aging 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for BIN2 Gene

Sources for BIN2 Gene

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