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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BIN2 Gene

protein-coding   GIFtS: 53
GCID: GC12M051697

Bridging Integrator 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bridging Integrator 21 2
Breast Cancer-Associated Protein 12 3
BRAP-12
Breast Cancer Associated Protein BRAP12
Bridging Integrator-22
BRAP13

External Ids:    HGNC: 10531   Entrez Gene: 514112   Ensembl: ENSG000001109347   OMIM: 6059365   UniProtKB: Q9UBW53   

Export aliases for BIN2 gene to outside databases

Previous GC identifers: GC12M051831 GC12M051391 GC12M049961 GC12M048707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BIN2 Gene: 
BIN2 (bridging integrator 2) is a protein-coding gene. Diseases associated with BIN2 include epididymo-orchitis, and orbital cellulitis. GO annotations related to this gene include phospholipid binding and protein domain specific binding. An important paralog of this gene is BIN1.

UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5
Function: Promotes cell motility and migration, probably via its interaction with the cell membrane and with
podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates
membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BIN2 gene promoter:
         c-Fos   AP-1   AML1a   Tal-1   HNF-4alpha2   HNF-4alpha1   E47   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBIN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BIN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

BIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIN2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051697:  view genomic region     (about GC identifiers)

Start:
51,674,822 bp from pter      End:
51,718,452 bp from pter
Size:
43,631 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5 (See protein sequence)
Recommended Name: Bridging integrator 2  
Size: 565 amino acids; 61874 Da
Subunit: Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain),
SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2
Subcellular location: Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic
side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in
phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at
podosomes, at an actin-rich ring-like structure
Sequence caution: Sequence=BAA91376.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91376.1; Type=Frameshift; Positions=156;
2 PDB 3D structures from and Proteopedia for BIN2:
4AVM (3D)        4I1Q (3D)    
Secondary accessions: Q86VV0 Q9NWK4 Q9UKN4
Alternative splicing: 2 isoforms:  Q9UBW5-1   Q9UBW5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BIN2: NX_Q9UBW5

Explore proteomics data for BIN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBW5

  • BIN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BIN2 Protein Expression
    REFSEQ proteins: NP_057377.2  
    ENSEMBL proteins: 
     ENSP00000474972   ENSP00000410217   ENSP00000267012   ENSP00000445874   ENSP00000474425  

    Human Recombinant Protein Products for BIN2: 
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    OriGene MassSpec for BIN2 
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    Novus Biologicals BIN2 Lysate
    Sino Biological Recombinant Protein for BIN2
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BIN2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891colocalizes with phagocytic cup IDA--
    GO:0002102podosome IDA--
    GO:0005737cytoplasm ----
    GO:0005938cell cortex IEA--
    GO:0030054cell junction IEA--

    BIN2 for ontologies           About GeneDecksing



    BIN2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for BIN2 

    Assay Products for BIN2: 
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    Cloud-Clone Corp. ELISAs for BIN2 
    Cloud-Clone Corp. CLIAs for BIN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR004148 BAR_dom
     IPR003005 Amphiphysin

    Graphical View of Domain Structure for InterPro Entry Q9UBW5

    ProtoNet protein and cluster: Q9UBW5

    UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5
    Domain: The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides
    Similarity: Contains 1 BAR domain


    BIN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIN2_HUMAN, Q9UBW5
    Function: Promotes cell motility and migration, probably via its interaction with the cell membrane and with
    podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates
    membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis
    Induction: Up-regulated during monocytic differentiation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10903846
    GO:0005543phospholipid binding IDA--
         
    BIN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BIN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BIN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIN2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate BIN2:
    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-4268 hsa-miR-1264 hsa-miR-3647-3p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidBIN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of BIN2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BIN2 (see all 6)
    OriGene ORF clones in mouse, rat for BIN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIN2 (NM_016293)
    Sino Biological Human cDNA Clone for BIN2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN2
    Sirion Biotech Customized lentivirus for stable overexpression of BIN2 
                         Customized lentivirus expression plasmids for stable overexpression of BIN2 

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    Search LifeMap BioReagents cell lines for BIN2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BIN2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for BIN2 (Q9UBW51, 3 ENSP000002670124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BIN1O004991, 3, ENSP000003167794EBI-2042570,EBI-719094 I2D: score=1 STRING: ENSP00000316779
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF1ENSP000002766034STRING: ENSP00000276603
    TINF2ENSP000002674154STRING: ENSP00000267415
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006911phagocytosis, engulfment IMP--
    GO:0060326cell chemotaxis IMP--
    GO:0071800podosome assembly IMP--
    GO:0097320membrane tubulation IDA--

    BIN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BIN2

    Search CenterWatch for drugs/clinical trials and news about BIN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BIN2 gene: 
    NM_016293.2  

    Unigene Cluster for BIN2:

    Bridging integrator 2
    Hs.14770  [show with all ESTs]
    Unigene Representative Sequence: AK225911
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604560 ENST00000605039 ENST00000452142(uc009zlz.3) ENST00000267012(uc001ryg.3 uc001ryh.3 uc010sng.2)
    ENST00000544402 ENST00000603177 ENST00000605819 ENST00000605423 ENST00000603260
    ENST00000604702
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIN2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate BIN2:
    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-4268 hsa-miR-1264 hsa-miR-3647-3p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidBIN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BIN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIN2
    Clone
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    OriGene clones in human, mouse for BIN2 (see all 6)
    OriGene ORF clones in mouse, rat for BIN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIN2 (NM_016293)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIN2
    Sirion Biotech Customized lentivirus for stable overexpression of BIN2 
                         Customized lentivirus expression plasmids for stable overexpression of BIN2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BIN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIN2

    Additional mRNA sequence: 

    AB032698.1 AF146531.1 AK000783.1 AK093638.1 AK225911.1 AK300211.1 AK314304.1 BC047686.1 

    8 DOTS entries:

    DT.213694  DT.92423269  DT.40123682  DT.95147399  DT.95265026  DT.100712927  DT.91647061  DT.92423270 

    24/120 AceView cDNA sequences (see all 120):

    AA776278 AK093638 AW768285 BX281612 AI052200 AI247125 AW440832 NM_016293 
    AA988660 BQ018830 BG388638 AA678263 BU753979 AW118269 BE466294 AA743030 
    AK000783 BI821299 BF902891 AI760011 BX415024 R06125 CD109693 BU742015 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BIN2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                          -                       -                                                               
    SP2:                          -                       -     -                                                         
    SP3:                          -                                                                                       
    SP4:                          -                                                                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for BIN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BIN2 expression in normal human tissues (normalized intensities)      BIN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCAGAAA
    BIN2 Expression
    About this image


    BIN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             lung ; macrophages   
     
     Tonsil (Hematopoietic System)
             tonsil ; non-germinal center cells   
     
     Lymph (Hematopoietic System)
             lymph node ; non-germinal center cells   

    See BIN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BIN2

    SOURCE GeneReport for Unigene cluster: Hs.14770

    UniProtKB/Swiss-Prot: BIN2_HUMAN, Q9UBW5
    Tissue specificity: Detected in natural killer cells (at protein level). Highest level expression seen in spleen
    and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting
    preferential expression in hematopoietic tissues

        SABiosciences Custom PCR Arrays for BIN2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BIN2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bin25 bridging integrator 2   --   15 (56.37 cM) 100641081 
    chicken
    (Gallus gallus)
    Aves BIN21 bridging integrator 2 58.65(n)
    55.85(a)
      777552  NM_001080896.1  NP_001074365.1 
    lizard
    (Anolis carolinensis)
    Reptilia BIN26
    Uncharacterized protein
    73(a)
    1 ↔ 1
    2(67617059-67691641)
    zebrafish
    (Danio rerio)
    Actinopterygii BC044473.12   -- 75.33(n)   327387  BC044473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Amph3 NOT synaptic vesicle endocytosis 36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F58G6.13 amphiphysin like 38(a)   IV(9644867-9647871)   --


    ENSEMBL Gene Tree for BIN2 (if available)
    TreeFam Gene Tree for BIN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BIN2 gene
    BIN12  AMPH2  
    2 SIMAP similar genes for BIN2 using alignment to 2 protein entries:     BIN2_HUMAN (see all proteins):
    BIN1    AMPH

    BIN2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for BIN2
    PGOHUM00000245980 PGOHUM00000235280 PGOHUM00000235657


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1002 SNPs in BIN2 are shown (see all 1002)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491555641,2
    --51674384(+) TCCCAA/GCCTCA 1 -- int10--------
    rs1432784711,2
    --51674393(+) CAGGCA/GATCCA 1 -- int10--------
    rs1816492081,2
    --51674409(+) CTCGGA/CCTCCC 1 -- int10--------
    rs1855393291,2
    --51674455(+) CAGCCA/GATATG 1 -- int10--------
    rs47619811,2
    C,F,A,H--51674501(+) ATATCC/TTCCTC 1 -- int133Minor allele frequency- T:0.44NS EA NA WA CSA 3202
    rs1902517411,2
    --51674526(+) CCTTAA/CTCATA 1 -- int10--------
    rs1483339441,2
    C--51674551(+) GTAAAC/TACCAG 1 -- int10--------
    rs1828462171,2
    --51674572(+) AAAATA/GTTATT 1 -- int10--------
    rs1867610471,2
    --51674628(+) GGAGCA/GCATGC 1 -- int10--------
    rs785146881,2
    C,F--51674652(+) AGAGTC/GTGTGG 1 -- int13Minor allele frequency- G:0.06WA NA EA 358

    HapMap Linkage Disequilibrium report for BIN2 (51674822 - 51718452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BIN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469377CNV Loss19166990
    nsv832408CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BIN2
    DNA2.0 Custom Variant and Variant Library Synthesis for BIN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605936    OMIM disorders: --

    6 diseases for BIN2:    About MalaCards
    epididymo-orchitis    orbital cellulitis    tricuspid valve insufficiency    orchitis
    cellulitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BIN2:
    epididymo-orchitis

    BIN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BIN2
    Human Genome Epidemiology (HuGE) Navigator: BIN2 (1 document)

    Export disorders for BIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BIN2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with BIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bin2, a functionally nonredundant member of the BAR adaptor gene family. (PubMed id 10903846)1, 2, 3 Ge K. and Prendergast G.C. (2000)
    2. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PubMed id 23285027)1, 2 Sanchez-Barrena M.J.... McMahon H.T. (2012)
    3. A genome-wide association study of aging. (PubMed id 21782286)1, 4 Walter S....Franceschini N. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51411 HGNC: 1053 AceView: BIN2 Ensembl:ENSG00000110934 euGenes: HUgn51411
    ECgene: BIN2 H-InvDB: BIN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BIN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BIN2 gene:
    Search GeneIP for patents involving BIN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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