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Aliases for BIN2 Gene

Aliases for BIN2 Gene

  • Bridging Integrator 2 2 3 5
  • Breast Cancer-Associated Protein 1 3 4
  • Breast Cancer Associated Protein BRAP1 3
  • BRAP-1 3
  • BRAP1 4

External Ids for BIN2 Gene

Previous GeneCards Identifiers for BIN2 Gene

  • GC12M051831
  • GC12M051697
  • GC12M051391
  • GC12M049961
  • GC12M048707
  • GC12M051674

Summaries for BIN2 Gene

GeneCards Summary for BIN2 Gene

BIN2 (Bridging Integrator 2) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is BIN1.

UniProtKB/Swiss-Prot for BIN2 Gene

  • Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIN2 Gene

Genomics for BIN2 Gene

Regulatory Elements for BIN2 Gene

Enhancers for BIN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G051317 1.6 FANTOM5 ENCODE dbSUPER 17 +1.6 1593 10.3 HDGF PKNOX1 ARNT WRNIP1 ZNF766 ZNF143 TBX21 ZNF592 ZNF579 MEF2D CELA1 BIN2 TFCP2 HNRNPA3P10 CSRNP2 POU6F1 DAZAP2 SMAGP SLC11A2 PHBP19
GH12G051368 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -46.0 -46007 4.4 PKNOX1 FEZF1 YY1 ZNF766 ZNF143 FOS DEK JUNB TBX21 SMARCA4 GALNT6 CELA1 BIN2 SLC4A8 DAZAP2 CSRNP2 FIGNL2 SLC11A2
GH12G051387 1.7 FANTOM5 ENCODE dbSUPER 11.7 -67.2 -67232 9.1 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 ZNF766 FOS ZNF263 GALNT6 BIN2 SLC11A2 CELA1 DAZAP2 SLC4A8 CSRNP2
GH12G051262 1.3 Ensembl ENCODE dbSUPER 15.3 +61.5 61547 1.1 HDAC1 CTCF ESRRA SIN3A RAD21 FOSL1 GTF3C2 ZNF121 GATA3 GATA2 HNRNPA3P10 BIN2 ATF1 DAZAP2 GALNT6 SLC4A8 SMAGP LOC102723983
GH12G051245 1.5 Ensembl ENCODE dbSUPER 10.5 +77.9 77854 2.8 PKNOX1 ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 NCOA1 POU6F1 RNU6-1273P BIN2 SLC11A2 DAZAP2 LOC102723983
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BIN2 on UCSC Golden Path with GeneCards custom track

Promoters for BIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051869 980 1001 CTCF WRNIP1 BACH1 MAX EBF1 ARID3A POLR2A EED ZNF143 ETV6

Genomic Location for BIN2 Gene

Chromosome:
12
Start:
51,281,038 bp from pter
End:
51,324,680 bp from pter
Size:
43,643 bases
Orientation:
Minus strand

Genomic View for BIN2 Gene

Genes around BIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIN2 Gene

Proteins for BIN2 Gene

  • Protein details for BIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW5-BIN2_HUMAN
    Recommended name:
    Bridging integrator 2
    Protein Accession:
    Q9UBW5
    Secondary Accessions:
    • Q86VV0
    • Q9NWK4
    • Q9UKN4

    Protein attributes for BIN2 Gene

    Size:
    565 amino acids
    Molecular mass:
    61874 Da
    Quaternary structure:
    • Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2.
    SequenceCaution:
    • Sequence=BAA91376.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91376.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BIN2 Gene

    Alternative splice isoforms for BIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIN2 Gene

Post-translational modifications for BIN2 Gene

  • Ubiquitination at posLast=6565
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BIN2 Gene

Domains & Families for BIN2 Gene

Gene Families for BIN2 Gene

Protein Domains for BIN2 Gene

Suggested Antigen Peptide Sequences for BIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBW5

UniProtKB/Swiss-Prot:

BIN2_HUMAN :
  • The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
Domain:
  • The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
genes like me logo Genes that share domains with BIN2: view

Function for BIN2 Gene

Molecular function for BIN2 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated during monocytic differentiation.

Gene Ontology (GO) - Molecular Function for BIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10903846
GO:0005543 phospholipid binding IDA 23285027
genes like me logo Genes that share ontologies with BIN2: view

Phenotypes for BIN2 Gene

genes like me logo Genes that share phenotypes with BIN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BIN2 Gene

Localization for BIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIN2 Gene

Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000269 PubMed:23285027}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIN2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
extracellular 4
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 colocalizes_with phagocytic cup IDA 23285027
GO:0002102 podosome IDA 23285027
GO:0005576 extracellular region TAS --
GO:0005938 cell cortex IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with BIN2: view

Pathways & Interactions for BIN2 Gene

genes like me logo Genes that share pathways with BIN2: view

Pathways by source for BIN2 Gene

3 Reactome pathways for BIN2 Gene

Interacting Proteins for BIN2 Gene

Gene Ontology (GO) - Biological Process for BIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006911 phagocytosis, engulfment IMP 23285027
GO:0043312 neutrophil degranulation TAS --
GO:0060326 cell chemotaxis IMP 23285027
GO:0071800 podosome assembly IMP 23285027
GO:0097320 plasma membrane tubulation IDA 23285027
genes like me logo Genes that share ontologies with BIN2: view

No data available for SIGNOR curated interactions for BIN2 Gene

Drugs & Compounds for BIN2 Gene

No Compound Related Data Available

Transcripts for BIN2 Gene

Unigene Clusters for BIN2 Gene

Bridging integrator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for BIN2 Gene

GeneLoc Exon Structure for
BIN2
ECgene alternative splicing isoforms for
BIN2

Expression for BIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BIN2 Gene

This gene is overexpressed in Whole Blood (x36.3).

Protein differential expression in normal tissues from HIPED for BIN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.4), Platelet (19.2), and Lavage (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BIN2 Gene



Protein tissue co-expression partners for BIN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BIN2 Gene:

BIN2

SOURCE GeneReport for Unigene cluster for BIN2 Gene:

Hs.14770

mRNA Expression by UniProt/SwissProt for BIN2 Gene:

Q9UBW5-BIN2_HUMAN
Tissue specificity: Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.

Evidence on tissue expression from TISSUES for BIN2 Gene

  • Blood(4.4)
  • Intestine(4.3)
  • Liver(4.2)
  • Bone marrow(2.4)
  • Lymph node(2.4)
  • Spleen(2.4)
genes like me logo Genes that share expression patterns with BIN2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BIN2 Gene

Orthologs for BIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIN2 34 35
  • 98.38 (n)
dog
(Canis familiaris)
Mammalia BIN2 34 35
  • 85.83 (n)
cow
(Bos Taurus)
Mammalia BIN2 34 35
  • 84.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BIN2 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bin2 34 16 35
  • 77.3 (n)
rat
(Rattus norvegicus)
Mammalia Bin2 34
  • 76.24 (n)
chicken
(Gallus gallus)
Aves BIN2 35
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIN2 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bin2b 35
  • 39 (a)
OneToMany
bin2a 35
  • 34 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Amph 36 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea F58G6.1 36
  • 38 (a)
amph-1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3172 35
  • 19 (a)
OneToMany
Species where no ortholog for BIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BIN2 Gene

ENSEMBL:
Gene Tree for BIN2 (if available)
TreeFam:
Gene Tree for BIN2 (if available)

Paralogs for BIN2 Gene

Paralogs for BIN2 Gene

(2) SIMAP similar genes for BIN2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for BIN2 Gene

genes like me logo Genes that share paralogs with BIN2: view

Variants for BIN2 Gene

Sequence variations from dbSNP and Humsavar for BIN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000101899 -- 51,281,727(+) TCACA(A/G)TATCT intron-variant
rs1000130252 -- 51,323,684(+) ACAAA(A/C)TTTGA intron-variant
rs1000134515 -- 51,281,237(+) ATGTA(A/T)AAAGT nc-transcript-variant, utr-variant-3-prime
rs1000143285 -- 51,292,421(+) TGCAT(A/G)TAATA intron-variant
rs1000159138 -- 51,322,837(+) AATGA(G/T)AGAAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for BIN2 Gene

Variant ID Type Subtype PubMed ID
nsv1138133 CNV deletion 24896259
nsv469377 CNV loss 19166990
nsv558877 CNV loss 21841781
nsv832408 CNV gain 17160897

Variation tolerance for BIN2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIN2 Gene

Disorders for BIN2 Gene

Relevant External Links for BIN2

Genetic Association Database (GAD)
BIN2
Human Genome Epidemiology (HuGE) Navigator
BIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BIN2

No disorders were found for BIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIN2 Gene

Publications for BIN2 Gene

  1. Bin2, a functionally nonredundant member of the BAR adaptor gene family. (PMID: 10903846) Ge K. … Prendergast G.C. (Genomics 2000) 2 3 4 64
  2. Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PMID: 23285027) Sanchez-Barrena M.J. … McMahon H.T. (PLoS ONE 2012) 3 4 64
  3. A genome-wide association study of aging. (PMID: 21782286) Walter S. … Franceschini N. (Neurobiol. Aging 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64

Products for BIN2 Gene

Sources for BIN2 Gene

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