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BIK Gene

protein-coding   GIFtS: 60
GCID: GC22P043506

BCL2-Interacting Killer (Apoptosis-Inducing)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BCL2-Interacting Killer (Apoptosis-Inducing)1 2     BP42 3
NBK2 3 5     Apoptosis-Inducing NBK2
Apoptosis Inducer NBK2 3     Bcl-2-Interacting Killer2
BIP12 3     

External Ids:    HGNC: 10511   Entrez Gene: 6382   Ensembl: ENSG000001002907   OMIM: 6033925   UniProtKB: Q133233   

Export aliases for BIK gene to outside databases

Previous GC identifers: GC22P040109 GC22P041737 GC22P041831 GC22P026465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BIK Gene:
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID,
BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic
members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is
suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic
proteins. (provided by RefSeq, Sep 2011)

GeneCards Summary for BIK Gene:
BIK (BCL2-interacting killer (apoptosis-inducing)) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and BH domain binding.

UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323
Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its
adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX

Gene Wiki entry for BIK (Bcl-2-interacting killer) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the BIK gene promoter:
         STAT5B   RFX1   AML1a   AP-4   GATA-1   FOXL1   GATA-6   HSF2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BIK promoter sequence
   Search Chromatin IP Primers for BIK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BIK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.31

BIK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIK gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P043506:  view genomic region     (about GC identifiers)

Start:
43,506,754 bp from pter      End:
43,525,718 bp from pter
Size:
18,965 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323 (See protein sequence)
Recommended Name: Bcl-2-interacting killer  
Size: 160 amino acids; 18016 Da
Subunit: Interacts with RHBDL4/RHBDD1
1 PDB 3D structure from and Proteopedia for BIK:
2IPE (3D)    
Secondary accessions: Q16582 Q6FH93

Explore the universe of human proteins at neXtProt for BIK: NX_Q13323

Explore proteomics data for BIK at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation
    by the proteosome-dependent mechanism1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BIK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001188.1  
    ENSEMBL proteins: 
     ENSP00000216115  

    BIK Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BIK

     
    Search eBioscience for Proteins for BIK 

     
    antibodies-online proteins for BIK (4 products) 

     
    antibodies-online peptides for BIK

    BIK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BIK
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    antibodies-online antibodies for BIK (100 products) 

    BIK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BIK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BIK
    Cloud-Clone Corp. CLIAs for BIK
    Search eBioscience for ELISAs for BIK 
    antibodies-online kits for BIK (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024579 Bcl2-int_killer
     IPR020728 Bcl2_BH3_motif_CS

    Graphical View of Domain Structure for InterPro Entry Q13323

    ProtoNet protein and cluster: Q13323

    1 Blocks protein domain: IPB000712 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323
    Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their
    interaction with anti-apoptotic members of the Bcl-2 family


    Find genes that share domains with BIK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIK_HUMAN, Q13323
    Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its
    adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX

         Genatlas biochemistry entry for BIK:
    BCL2-interacting killer (apoptosis-inducing)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15694340
    GO:0046982protein heterodimerization activity IEA--
    GO:0051400BH domain binding IEA--
         
    Find genes that share ontologies with BIK           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bik):
     endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system  mortality/aging 
     normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with BIK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Biktm1Ast for BIK

       genOway: Develop your customized and physiologically relevant rodent model for BIK

    miRNA
    Products:
        
    miRTarBase miRNAs that target BIK:
    hsa-mir-335-5p (MIRT019109), hsa-mir-9-5p (MIRT021409), hsa-mir-148b-3p (MIRT019414)

    Block miRNA regulation of human, mouse, rat BIK using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate BIK:
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-4261 hsa-miR-3194-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidBIK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BIK
    Predesigned siRNA for gene silencing in human, mouse, rat BIK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BIK

    Clone
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    OriGene clones in human, mouse for BIK (see all 6)
    OriGene ORF clones in mouse, rat for BIK
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    GenScript: all cDNA clones in your preferred vector: BIK (NM_001197)
    Sino Biological Human cDNA Clone for BIK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIK
    Addgene plasmids for BIK 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BIK_HUMAN, Q13323: Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass
    membrane protein (By similarity). Note=Around the nuclear envelope, and in cytoplasmic membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    endoplasmic reticulum2
    cytosol1
    golgi apparatus1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005740mitochondrial envelope ----
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    Find genes that share ontologies with BIK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BIK About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74
    2TNF Signaling
    Death Receptor Signaling0.50
    3Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    4Wnt Signaling Pathway (WikiPathways)
    DNA damage response (only ATM dependent)0.32
    5Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics


    Find genes that share SuperPaths with BIK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BIK
        DHA Signaling

    1 Cell Signaling Technology (CST) Pathway for BIK
        Apoptosis and Autophagy

    1 GeneGo (Thomson Reuters) Pathway for BIK
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    2 BioSystems Pathways for BIK
        Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)

    1 Sino Biological Pathway for BIK
        Death Receptor Signaling

    1 PharmGKB Pathway for BIK
        Busulfan Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIK: 
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BIK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for BIK (Q133231, 2, 3 ENSP000002161154) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2L2Q928431, 3, ENSP000002504054EBI-700794,EBI-707714 I2D: score=5 STRING: ENSP00000250405
    BCL2L1Q078171, 3, ENSP000003025644EBI-700794,EBI-78035 I2D: score=7 STRING: ENSP00000302564
    BCL2P104151, 3, ENSP000003296234EBI-700794,EBI-77694 I2D: score=6 STRING: ENSP00000329623
    BCL2L2-PABPN1Q928431, 3EBI-700794,EBI-707714 I2D: score=5 
    BNC1Q019543, ENSP000003070414I2D: score=1 STRING: ENSP00000307041
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS10381623
    GO:0007283spermatogenesis IEA--
    GO:0008584male gonad development IEA--
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0032464positive regulation of protein homooligomerization IDA--

    Find genes that share ontologies with BIK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BIK

    5 Novoseek inferred chemical compound relationships for BIK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bortezomib 65.6 9 15767553 (6), 15824729 (1)
    mg 132 55.1 3 16082182 (1), 17047080 (1)
    fulvestrant 54.6 3 14983013 (2), 17047080 (1)
    sp 600125 42.6 1 16082182 (1)
    estrogen 7.87 7 14983013 (3), 17440086 (3)



    Find genes that share compounds with BIK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BIK gene: 
    NM_001197.4  

    Unigene Cluster for BIK:

    BCL2-interacting killer (apoptosis-inducing)
    Hs.475055  [show with all ESTs]
    Unigene Representative Sequence: BE561321
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000216115(uc003bdk.3)
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate BIK:
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-4261 hsa-miR-3194-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidBIK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BIK
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    GenScript: all cDNA clones in your preferred vector: BIK (NM_001197)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BIK
      QuantiTect SYBR Green Assays in human, mouse, rat BIK
      QuantiFast Probe-based Assays in human, mouse, rat BIK

    Additional mRNA sequence: 

    BC001599.1 BT006728.1 CR456390.1 CR541863.1 CR541883.1 U34584.1 U49730.1 

    2 DOTS entries:

    DT.311800  DT.120646528 

    Selected AceView cDNA sequences (see all 47):

    NM_001197 BC001599 BM765910 AW510740 BM982248 BX107823 AI620444 BF514281 
    AA835642 AI478735 U49730 BG697020 BF063173 BG057298 AA731234 AI797545 
    AW274694 BF064055 U34584 AI798122 AI659037 AA731232 AA291322 BE269083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BIK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTTTTT
    BIK Expression
    About this image

    BIK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BIK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475055
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BIK: 
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for BIK gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bik1 , 5 BCL2-interacting killer1, 5 62.4(n)1
    46.4(a)1
      15 (39.40 cM)5
    121241  NM_007546.21  NP_031572.11 
     835268625 


    ENSEMBL Gene Tree for BIK (if available)
    TreeFam Gene Tree for BIK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BIK (see all 556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475470331,2
    --43504826(+) CCACCA/GTGCCC 1 -- us2k10--------
    rs1900831541,2
    --43504871(+) CTTGGG/TATTTT 1 -- us2k10--------
    rs1401881001,2
    --43504894(+) AGTACC/TGTATT 1 -- us2k10--------
    rs1499846951,2
    --43504929(+) TCCAGC/TGTCCC 1 -- us2k10--------
    rs110901411,2
    H--43504990(+) CCTACA/TTACCT 1 -- us2k15Minor allele frequency- T:0.00NA NS EA 458
    rs1451572241,2
    --43504994(+) CATACC/TTGGCA 1 -- us2k10--------
    rs49883601,2
    C,F,H--43505071(+) GACCCC/TGTGTC 1 -- us2k123Minor allele frequency- T:0.07NS NA EA WA 2842
    rs49883611,2
    C,F,H--43505072(+) ACCCCG/ATGTCA 1 -- us2k110Minor allele frequency- A:0.03NS EA WA 1558
    rs1491697011,2
    --43505074(+) CCCGTA/GTCATT 1 -- us2k10--------
    rs412775111,2
    C--43505143(+) CCATTA/G/TTGAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BIK (43506754 - 43525718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BIK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33816CNV Gain17666407
    nsv459889CNV Gain19166990
    nsv834214CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BIK
    DNA2.0 Custom Variant and Variant Library Synthesis for BIK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603392    OMIM disorders: --


    Find genes that share disorders with BIK           About GenesLikeMe

    8 Novoseek inferred disease relationships for BIK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 26.2 10 14633680 (2), 17027756 (2), 12467227 (1), 17064661 (1) (see all 7)
    lymphoma 17 2 12874789 (1)
    lymphoma b-cell 15.3 4 12874789 (3)
    breast cancer 14.3 13 14983013 (3), 17440086 (3), 17047080 (3), 11782349 (1)
    tumors 9.86 15 16060964 (3), 12467227 (2), 14633680 (2), 12696008 (1) (see all 9)
    ovarian cancer 0.779 2 15498571 (2)
    necrosis 0 2 12696008 (1), 19494838 (1)
    metastasis 0 3 17194181 (1), 14633680 (1)

    Genetic Association Database (GAD): BIK
    Human Genome Epidemiology (HuGE) Navigator: BIK (21 documents)

    Export disorders for BIK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BIK gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with BIK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. (PubMed id 7478623)1, 2, 3, 9 Boyd J.M....Chinnadurai G. (Oncogene 1995)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. (PubMed id 8816500)1, 2, 9 Han J.... White E. (Mol. Cell. Biol. 1996)
    4. Genome-wide association study identifies new prostate cancer susceptibility loci. (PubMed id 21743057)1, 4 Schumacher F.R....Kraft P. (Hum. Mol. Genet. 2011)
    5. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (Prostate 2010)
    6. BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. (PubMed id 19898928)1, 4 Isaian A....Sanati M.H. (J. Clin. Immunol. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. (PubMed id 19767753)1, 4 Eeles R.A....Easton D.F. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 638 HGNC: 1051 AceView: BIK Ensembl:ENSG00000100290 euGenes: HUgn638
    ECgene: BIK H-InvDB: BIK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BIK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bik/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BIK gene:
    Search GeneIP for patents involving BIK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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