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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BIK Gene

protein-coding   GIFtS: 60
GCID: GC22P043506

BCL2-Interacting Killer (Apoptosis-Inducing)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Interacting Killer (Apoptosis-Inducing)1 2     BP42 3
NBK2 3 5     Apoptosis-Inducing NBK2
Apoptosis Inducer NBK2 3     Bcl-2-Interacting Killer2
BIP12 3     

External Ids:    HGNC: 10511   Entrez Gene: 6382   Ensembl: ENSG000001002907   OMIM: 6033925   UniProtKB: Q133233   

Export aliases for BIK gene to outside databases

Previous GC identifers: GC22P040109 GC22P041737 GC22P041831 GC22P026465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BIK Gene:
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID,
BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic
members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is
suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic
proteins. (provided by RefSeq, Sep 2011)

GeneCards Summary for BIK Gene: 
BIK (BCL2-interacting killer (apoptosis-inducing)) is a protein-coding gene. Diseases associated with BIK include multiple myeloma, and ataxia telangiectasia, and among its related super-pathways are p53 Mediated Apoptosis and Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins. GO annotations related to this gene include protein heterodimerization activity and BH domain binding.

UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323
Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its
adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX

Gene Wiki entry for BIK (Bcl-2-interacting killer) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BIK gene promoter:
         STAT5B   RFX1   AML1a   AP-4   GATA-1   FOXL1   GATA-6   HSF2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BIK promoter sequence
   Search SABiosciences Chromatin IP Primers for BIK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.31

BIK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BIK gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P043506:  view genomic region     (about GC identifiers)

Start:
43,506,754 bp from pter      End:
43,525,718 bp from pter
Size:
18,965 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323 (See protein sequence)
Recommended Name: Bcl-2-interacting killer  
Size: 160 amino acids; 18016 Da
Subunit: Interacts with RHBDL4/RHBDD1
Subcellular location: Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass
membrane protein (By similarity). Note=Around the nuclear envelope, and in cytoplasmic membranes
1 PDB 3D structure from and Proteopedia for BIK:
2IPE (3D)    
Secondary accessions: Q16582 Q6FH93

Explore the universe of human proteins at neXtProt for BIK: NX_Q13323

Explore proteomics data for BIK at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation
    by the proteosome-dependent mechanism
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13323

  • BIK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BIK Protein Expression
    REFSEQ proteins: NP_001188.1  
    ENSEMBL proteins: 
     ENSP00000216115  

    Human Recombinant Protein Products for BIK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for BIK
    GenScript Custom Purified and Recombinant Proteins Services for BIK
    Novus Biologicals BIK Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BIK 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005740mitochondrial envelope ----
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    BIK for ontologies           About GeneDecksing



    BIK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BIK
    R&D Systems Antibodies for BIK
    Cell Signaling Technology (CST) Antibodies for BIK 
    OriGene Antibodies for BIK
    OriGene Custom Antibody Services for BIK
    GenScript Custom Superior Antibodies Services for BIK
    Novus Biologicals BIK Antibodies
    Abcam antibodies for BIK
    Cloud-Clone Corp. Antibodies for BIK 
    ThermoFisher Antibodies for BIK
    LSBio Antibodies in human, mouse, rat for BIK 

    Assay Products for BIK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BIK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BIK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BIK 
    Cloud-Clone Corp. CLIAs for BIK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024579 Bcl2-int_killer
     IPR020728 Bcl2_BH3_motif_CS

    Graphical View of Domain Structure for InterPro Entry Q13323

    ProtoNet protein and cluster: Q13323

    1 Blocks protein domain: IPB000712 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323
    Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their
    interaction with anti-apoptotic members of the Bcl-2 family


    BIK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BIK_HUMAN, Q13323
    Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its
    adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX

         Genatlas biochemistry entry for BIK:
    BCL2-interacting killer (apoptosis-inducing)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15694340
    GO:0046982protein heterodimerization activity IEA--
    GO:0051400BH domain binding IEA--
         
    BIK for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bik):
     cellular  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     mortality/aging  normal  renal/urinary system  reproductive system 

    BIK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Biktm1Ast for BIK

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BIK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BIK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BIK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BIK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIK
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BIK:
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-4261 hsa-miR-3194-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidBIK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BIK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BIK
    Sirion Biotech Customized adenovirus for overexpression of BIK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BIK (see all 7)
    OriGene ORF clones in mouse, rat for BIK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIK (NM_001197)
    Sino Biological Human cDNA Clone for BIK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIK
    Sirion Biotech Customized lentivirus for stable overexpression of BIK 
                         Customized lentivirus expression plasmids for stable overexpression of BIK 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BIK
    Search LifeMap BioReagents cell lines for BIK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BIK About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74
    2Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins1.00
    3TNF Signaling
    Death Receptor Signaling0.50
    4Apoptosis Modulation and Signaling
    Apoptosis Modulation and Signaling0.38
    5Wnt Signaling Pathway
    DNA damage response (only ATM dependent)0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BIK
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BIK
        DHA Signaling

    1 Cell Signaling Technology (CST) Pathway for BIK
        Apoptosis and Autophagy

    1 GeneGo (Thomson Reuters) Pathway for BIK
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    2 BioSystems Pathways for BIK
        Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)

    1 Sino Biological Pathway for BIK 
        Death Receptor Signaling

    1 PharmGKB Pathway for BIK
        Busulfan Pathway, Pharmacodynamics


    BIK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/17 Interacting proteins for BIK (Q133231, 2, 3 ENSP000002161154) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2L2Q928431, 3, ENSP000002504054EBI-700794,EBI-707714 I2D: score=5 STRING: ENSP00000250405
    BCL2L1Q078171, 3, ENSP000003025644EBI-700794,EBI-78035 I2D: score=7 STRING: ENSP00000302564
    BCL2P104151, 3, ENSP000003296234EBI-700794,EBI-77694 I2D: score=6 STRING: ENSP00000329623
    BCL2L2-PABPN1Q928431, 3EBI-700794,EBI-707714 I2D: score=5 
    BNC1Q019543, ENSP000003070414I2D: score=1 STRING: ENSP00000307041
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS10381623
    GO:0007283spermatogenesis IEA--
    GO:0008584male gonad development IEA--
    GO:0032464positive regulation of protein homooligomerization IDA--
    GO:0090200positive regulation of release of cytochrome c from mitochondria IDA--

    BIK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BIK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BIK

    5 Novoseek inferred chemical compound relationships for BIK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bortezomib 65.6 9 15767553 (6), 15824729 (1)
    mg 132 55.1 3 16082182 (1), 17047080 (1)
    fulvestrant 54.6 3 14983013 (2), 17047080 (1)
    sp 600125 42.6 1 16082182 (1)
    estrogen 7.87 7 14983013 (3), 17440086 (3)

    Search CenterWatch for drugs/clinical trials and news about BIK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BIK gene: 
    NM_001197.4  

    Unigene Cluster for BIK:

    BCL2-interacting killer (apoptosis-inducing)
    Hs.475055  [show with all ESTs]
    Unigene Representative Sequence: BE561321
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000216115(uc003bdk.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BIK
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BIK:
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-4261 hsa-miR-3194-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidBIK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BIK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIK
    Clone
    Products:
         
    OriGene clones in human, mouse for BIK (see all 7)
    OriGene ORF clones in mouse, rat for BIK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BIK (NM_001197)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BIK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIK
    Sirion Biotech Customized lentivirus for stable overexpression of BIK 
                         Customized lentivirus expression plasmids for stable overexpression of BIK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BIK
    OriGene qSTAR qPCR primer pairs in human, mouse for BIK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIK

    Additional mRNA sequence: 

    BC001599.1 BT006728.1 CR456390.1 CR541863.1 CR541883.1 U34584.1 U49730.1 

    2 DOTS entries:

    DT.311800  DT.120646528 

    24/47 AceView cDNA sequences (see all 47):

    NM_001197 BX107823 AW510740 BC001599 AI620444 BM982248 BM765910 AI347538 
    AI659037 AI798122 BG057298 BG697020 BE269083 AI478735 BF514281 AA731234 
    BF064055 AW274694 AI797545 AA291322 U34584 U49730 AA731232 BF063173 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BIK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTTTTT
    BIK Expression
    About this image


    See BIK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BIK

    SOURCE GeneReport for Unigene cluster: Hs.475055
        SABiosciences Expression via Pathway-Focused PCR Arrays including BIK: 
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BIK
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BIK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for BIK gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bik1 , 5 BCL2-interacting killer1, 5 61.33(n)1
    43.33(a)1
      15 (39.40 cM)5
    121241  NM_007546.21  NP_031572.11 
     835268625 


    ENSEMBL Gene Tree for BIK (if available)
    TreeFam Gene Tree for BIK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/556 SNPs in BIK are shown (see all 556)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475470331,2
    --43504826(+) CCACCA/GTGCCC 1 -- us2k10--------
    rs1900831541,2
    --43504871(+) CTTGGG/TATTTT 1 -- us2k10--------
    rs1401881001,2
    --43504894(+) AGTACC/TGTATT 1 -- us2k10--------
    rs1499846951,2
    --43504929(+) TCCAGC/TGTCCC 1 -- us2k10--------
    rs110901411,2
    H--43504990(+) CCTACA/TTACCT 1 -- us2k15Minor allele frequency- T:0.00NA NS EA 458
    rs1451572241,2
    --43504994(+) CATACC/TTGGCA 1 -- us2k10--------
    rs49883601,2
    C,F,H--43505071(+) GACCCC/TGTGTC 1 -- us2k123Minor allele frequency- T:0.07NS NA EA WA 2842
    rs49883611,2
    C,F,H--43505072(+) ACCCCG/ATGTCA 1 -- us2k110Minor allele frequency- A:0.03NS EA WA 1558
    rs1491697011,2
    --43505074(+) CCCGTA/GTCATT 1 -- us2k10--------
    rs412775111,2
    C--43505143(+) CCATTA/G/TTGAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BIK (43506754 - 43525718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BIK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33816CNV Gain17666407
    nsv459889CNV Gain19166990
    nsv834214CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BIK
    DNA2.0 Custom Variant and Variant Library Synthesis for BIK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603392    OMIM disorders: --

    20/25 diseases for BIK (see all 25):    About MalaCards
    multiple myeloma    ataxia telangiectasia    hodgkin's lymphoma    non-hodgkin lymphoma
    myeloma    chronic lymphocytic leukemia    ataxia    b-cell lymphomas
    renal cell carcinoma    gastric cancer    schizophrenia    pancreatic cancer
    breast cancer    thyroiditis    pancreatitis    myeloid leukemia
    colorectal cancer    prostate cancer    leukemia    lung cancer


    BIK for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for BIK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 26.2 10 14633680 (2), 17027756 (2), 12467227 (1), 17064661 (1) (see all 7)
    lymphoma 17 2 12874789 (1)
    lymphoma b-cell 15.3 4 12874789 (3)
    breast cancer 14.3 13 14983013 (3), 17440086 (3), 17047080 (3), 11782349 (1)
    tumors 9.86 15 16060964 (3), 12467227 (2), 14633680 (2), 12696008 (1) (see all 9)
    ovarian cancer 0.779 2 15498571 (2)
    necrosis 0 2 12696008 (1), 19494838 (1)
    metastasis 0 3 17194181 (1), 14633680 (1)

    Genetic Association Database (GAD): BIK
    Human Genome Epidemiology (HuGE) Navigator: BIK (21 documents)

    Export disorders for BIK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BIK gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with BIK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. (PubMed id 7478623)1, 2, 3, 9 Boyd J.M....Chinnadurai G. (1995)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    3. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. (PubMed id 8816500)1, 2, 9 Han J.... White E. (1996)
    4. Genome-wide association study identifies new prostate cancer susceptibility loci. (PubMed id 21743057)1, 4 Schumacher F.R....Kraft P. (2011)
    5. Prostate cancer risk-associated variants reported fro m genome-wide association studies: meta-analysis and their contribution to gene tic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (2010)
    6. BAK, BAX, and NBK/BIK proapoptotic gene alterations i n iranian patients with ataxia telangiectasia. (PubMed id 19898928)1, 4 Isaian A....Sanati M.H. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Identification of seven new prostate cancer susceptib ility loci through a genome-wide association study. (PubMed id 19767753)1, 4 Eeles R.A....Cao G. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 638 HGNC: 1051 AceView: BIK Ensembl:ENSG00000100290 euGenes: HUgn638
    ECgene: BIK H-InvDB: BIK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BIK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BIK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bik/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BIK gene:
    Search GeneIP for patents involving BIK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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