BIK Gene
protein-coding GIFtS: 57
GCID: GC22P043506
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|
BCL2-interacting killer (apoptosis-inducing)
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Aliases
for BIK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BCL2-Interacting Killer (Apoptosis-Inducing)1 2 | | BP42 3 | | NBK1 2 3 5 | | Apoptosis-Inducing NBK2 | | Apoptosis Inducer NBK2 3 | | Bcl-2-Interacting Killer2 | | BIP12 3 | | |
Export aliases for BIK gene to outside databasesPrevious GC identifers: GC22P040109 GC22P041737 GC22P041831 GC22P026465 |
Summaries
for BIK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BIK:
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK,BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of theBCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presenceof survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. (provided by RefSeq,Sep 2011)
UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or itsadenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX
Gene Wiki entry for BIK (Bcl-2-interacting killer)
|
Genomic Views
for BIK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BIK gene promoter:
STAT5B RFX1 AML1a AP-4 GATA-1 FOXL1 GATA-6 HSF2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for BIK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.31BIK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P043506: view genomic region
(about GC identifiers)
Start:
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43,506,754 bp from pter |
End:
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43,525,718 bp from pter |
Size:
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18,965 bases |
Orientation:
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plus strand |
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Proteins
for BIK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323 (See
protein sequence)Recommended Name: Bcl-2-interacting killer Size: 160 amino acids; 18016 Da
Subunit: Interacts with RHBDL4/RHBDD1
Subcellular location: Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membraneprotein (By similarity). Note=Around the nuclear envelope, and in cytoplasmic membranes
1 PDB 3D structure from  and Proteopedia  for BIK:2IPE (3D)
Secondary accessions: Q16582 Q6FH93Explore the universe of human proteins at neXtProt for BIK: NX_Q13323
Post-translational modifications:
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation bythe proteosome-dependent mechanism1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13323
BIK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001188.1
ENSEMBL proteins: ENSP00000216115
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
BIK for ontologies About GeneDecksing
BIK Antibody Products:
Assay Products for BIK: |
Protein
Domains /
Families
for BIK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BIK for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13323ProtoNet protein and cluster: Q13323 1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein
UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for theirinteraction with anti-apoptotic members of the Bcl-2 family |
Function
for BIK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIK_HUMAN, Q13323Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or itsadenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX Genatlas biochemistry entry for BIK:BCL2-interacting killer (apoptosis-inducing)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for BIK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIK |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
BIK for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Biktm1Ast for BIK
9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bik):
BIK for phenotypes About GeneDecksing
|
Pathways & Interactions
for BIK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | | | 2 | Apoptosis and Autophagy | | | 3 | Busulfan Pathway, Pharmacodynamics | | | 4 | Apoptosis Modulation and Signaling | | | 5 | Apoptotic Pathways in Synovial Fibroblasts | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for BIK
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BIK
1 
Cell Signaling Technology (CST) Pathway for BIK
1  GeneGo (Thomson Reuters) Pathway for BIK
2  BioSystems Pathways for BIK
1  PharmGKB Pathway for BIK
BIK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BIK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/17 Interacting proteins for BIK (Q133231, 2, 3 ENSP000002161154) via UniProtKB, MINT, STRING, and/or I2D (see all 17)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BCL2L2 | Q928431, 3, ENSP000002504054 | EBI-700794,EBI-707714 I2D:
score=5 STRING: ENSP00000250405 | | BCL2L1 | Q078171, 3, ENSP000003025644 | EBI-700794,EBI-78035 I2D:
score=7 STRING: ENSP00000302564 | | BCL2 | P104151, 3, ENSP000003296234 | EBI-700794,EBI-77694 I2D:
score=6 STRING: ENSP00000329623 | | BCL2L2-PABPN1 | Q928431, 3 | EBI-700794,EBI-707714 I2D:
score=5 | | BNC1 | Q019543, ENSP000003070414 | I2D:
score=1 STRING: ENSP00000307041 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
BIK for ontologies About GeneDecksing
|
Drugs & Compounds
for BIK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BIK for compounds About GeneDecksing
 Browse Tocris compounds for BIK
5 Novoseek chemical compound relationships for BIK gene About this table
Search CenterWatch for drugs/clinical trials and news about BIK
|
Transcripts
for BIK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BIK gene: NM_001197.4 Unigene Cluster for BIK: BCL2-interacting killer (apoptosis-inducing) Hs.475055 [show with all ESTs]Unigene Representative Sequence: BE5613211 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000216115(uc003bdk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BIK (NM_001197) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BIK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BIK |
Additional cDNA sequence: BC001599.1 BT006728.1 CR456390.1 CR541863.1 CR541883.1 U34584.1 U49730.1 2 DOTS entries: DT.311800 DT.120646528 24/47 AceView cDNA sequences (see all 47): AW510740 BM765910 AI620444 BC001599 BX107823 BM982248 NM_001197 BE269083 AW274694 AA731234 AA731232 AI347538 BG697020 AI659037 BF064055 U49730 BF514281 AA835642 AI797545 BF063173 AI478735 AI684897 AA291322 BG057298
GeneLoc Exon Structure
|
Expression
for BIK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BIK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCCTTTTT
About this image
See BIK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BIK
SOURCE GeneReport for Unigene cluster: Hs.475055
SABiosciences Expression via Pathway-Focused PCR Arrays including BIK:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BIK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIK |
Orthologs
for BIK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for BIK gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for BIK (if available)
TreeFam Gene Tree for BIK (if available) |
Paralogs
for BIK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BIK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BIK (43506754 - 43525718 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BIK
1 CNV: 7352 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIK |
|
Disorders
/ Diseases
for BIK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BIK for disorders About GeneDecksing
OMIM gene information: 603392
OMIM disorders: --
20/26  diseases for BIK (see all 26): About MalaCardsnon-hodgkin lymphoma b-cell lymphomas hodgkin's lymphoma ataxia telangiectasia
chronic lymphocytic leukemia lymphocytic leukemia renal cell carcinoma multiple myeloma
myeloid leukemia breast cancer myeloma ataxia
thyroid carcinoma leukemia gastric cancer pancreatic cancer
colorectal cancer thyroiditis lung cancer prostate cancer
8 Novoseek disease relationships for BIK gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
26.2 |
10 |
14633680 (2), 17027756 (2), 12467227 (1), 17064661 (1) (see all 7) |
| lymphoma |
17 |
2 |
12874789 (1) |
| lymphoma b-cell |
15.3 |
4 |
12874789 (3) |
| breast cancer |
14.3 |
13 |
14983013 (3), 17440086 (3), 17047080 (3), 11782349 (1) |
| tumors |
9.86 |
15 |
16060964 (3), 12467227 (2), 14633680 (2), 12696008 (1) (see all 9) |
| ovarian cancer |
0.779 |
2 |
15498571 (2) |
| necrosis |
0 |
2 |
12696008 (1), 19494838 (1) |
| metastasis |
0 |
3 |
17194181 (1), 14633680 (1) |
Human Genome Epidemiology (HuGE) Navigator: BIK (21 documents)
Export disorders for BIK gene to outside databases
|
Publications
for BIK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BIK gene, integrated from 9 sources (see all 112):
(articles sorted by number of sources associating them with BIK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. (PubMed id 7478623)1, 2, 3, 9 Boyd J.M....Chinnadurai G. (1995)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
- Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. (PubMed id 8816500)1, 2, 9 Han J.... White E. (1996)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. (PubMed id 10500065)1, 2 Castells A.... Rustgi A.K. (1999)
- A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. (PubMed id 8521816)1, 2 Chittenden T.... Lutz R.J. (1995)
- Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein. (PubMed id 17047080)1, 9 Hur J....Shioda T. (2006)
- Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis. (PubMed id 11342619)1, 9 Jiang A. and Clark E.A. (2001)
- Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells. (PubMed id 17027756)1, 9 Real P.J....Fernandez-Luna J.L. (2006)
|
External Searches for BIK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BIK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BIK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BIK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BIK gene:
Search GeneIP for patents involving BIK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BIK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BIK | | OriGene shRNA RFP for BIK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BIK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BIK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BIK | | OriGene 3'-UTR Clone for BIK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BIK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BIK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BIK | | OriGene Custom Protein Services for BIK | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BIK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BIK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BIK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BIK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BIK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BIK |
| |
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| | Antibodies & Assays for BIK |
| | | | Search Tocris compounds for BIK |
| |  |  |  |  | | | | |
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 |
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| | | |  |  |  | | | | ThermoFisher Antibodies for BIK |
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