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Aliases for BIK Gene

Aliases for BIK Gene

  • BCL2-Interacting Killer (Apoptosis-Inducing) 2 3
  • NBK 3 4 6
  • Apoptosis Inducer NBK 3 4
  • BIP1 3 4
  • BP4 3 4
  • Bcl-2-Interacting Killer 3
  • Apoptosis-Inducing NBK 3

External Ids for BIK Gene

Summaries for BIK Gene

Entrez Gene Summary for BIK Gene

  • The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for BIK Gene

BIK (BCL2-Interacting Killer (Apoptosis-Inducing)) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis (WikiPathways). GO annotations related to this gene include protein heterodimerization activity and BH domain binding.

UniProtKB/Swiss-Prot for BIK Gene

  • Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.

Gene Wiki entry for BIK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIK Gene

Genomics for BIK Gene

Genomic Location for BIK Gene

Start:
43,110,748 bp from pter
End:
43,129,712 bp from pter
Size:
18,965 bases
Orientation:
Plus strand

Genomic View for BIK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIK Gene

Regulatory Elements for BIK Gene

Proteins for BIK Gene

  • Protein details for BIK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13323-BIK_HUMAN
    Recommended name:
    Bcl-2-interacting killer
    Protein Accession:
    Q13323
    Secondary Accessions:
    • Q16582
    • Q6FH93

    Protein attributes for BIK Gene

    Size:
    160 amino acids
    Molecular mass:
    18016 Da
    Quaternary structure:
    • Interacts with RHBDL4/RHBDD1.

    Three dimensional structures from OCA and Proteopedia for BIK Gene

neXtProt entry for BIK Gene

Proteomics data for BIK Gene at MOPED

Post-translational modifications for BIK Gene

  • Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BIK Gene

Domains for BIK Gene

Protein Domains for BIK Gene

UniProtKB/Swiss-Prot:

BIK_HUMAN
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family:
    • Q13323
genes like me logo Genes that share domains with BIK: view

No data available for Gene Families for BIK Gene

Function for BIK Gene

Molecular function for BIK Gene

GENATLAS Biochemistry: BCL2-interacting killer (apoptosis-inducing)
UniProtKB/Swiss-Prot Function: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.

Gene Ontology (GO) - Molecular Function for BIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15694340
GO:0046982 protein heterodimerization activity IEA --
GO:0051400 BH domain binding IEA --
genes like me logo Genes that share ontologies with BIK: view
genes like me logo Genes that share phenotypes with BIK: view

Animal Models for BIK Gene

MGI Knock Outs for BIK:

miRNA for BIK Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BIK Gene

Localization for BIK Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIK Gene

Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIK Gene COMPARTMENTS Subcellular localization image for BIK gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005740 mitochondrial envelope --
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with BIK: view

Pathways for BIK Gene

genes like me logo Genes that share pathways with BIK: view

Pathways by source for BIK Gene

1 Sino Biological pathway for BIK Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for BIK Gene
1 Qiagen pathway for BIK Gene
1 Cell Signaling Technology pathway for BIK Gene
1 PharmGKB pathway for BIK Gene

Gene Ontology (GO) - Biological Process for BIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10381623
GO:0007283 spermatogenesis IEA --
GO:0008584 male gonad development IBA --
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0032464 positive regulation of protein homooligomerization IDA 21041309
genes like me logo Genes that share ontologies with BIK: view

Compounds for BIK Gene

(5) Novoseek inferred chemical compound relationships for BIK Gene

Compound -log(P) Hits PubMed IDs
bortezomib 65.6 7
mg 132 55.1 2
fulvestrant 54.6 3
sp 600125 42.6 1
estrogen 7.87 6
genes like me logo Genes that share compounds with BIK: view

Transcripts for BIK Gene

mRNA/cDNA for BIK Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BIK Gene

BCL2-interacting killer (apoptosis-inducing):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIK Gene

No ASD Table

Relevant External Links for BIK Gene

GeneLoc Exon Structure for
BIK
ECgene alternative splicing isoforms for
BIK

Expression for BIK Gene

mRNA expression in normal human tissues for BIK Gene

mRNA differential expression in normal tissues according to GTEx for BIK Gene

This gene is overexpressed in Minor Salivary Gland (7.7), Colon - Transverse (5.2), Esophagus - Mucosa (4.5), and Prostate (4.2).

SOURCE GeneReport for Unigene cluster for BIK Gene Hs.475055

genes like me logo Genes that share expressions with BIK: view

Orthologs for BIK Gene

This gene was present in the common ancestor of mammals.

Orthologs for BIK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIK 36
  • 98.75 (n)
  • 98.12 (a)
BIK 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIK 37
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bik 36
  • 62.4 (n)
  • 46.4 (a)
Bik 16
Bik 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bik 36
  • 65.61 (n)
  • 52.38 (a)
Species with no ortholog for BIK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BIK Gene

ENSEMBL:
Gene Tree for BIK (if available)
TreeFam:
Gene Tree for BIK (if available)

Paralogs for BIK Gene

No data available for Paralogs for BIK Gene

Variants for BIK Gene

Sequence variations from dbSNP and Humsavar for BIK Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs735573 -- 43,127,450(+) CCCAG(C/G)ATTCT intron-variant
rs735574 -- 43,127,398(+) CTGCC(C/T)GTTCC intron-variant
rs735575 -- 43,127,195(+) GGTGG(C/T)GCCAG intron-variant
rs738276 -- 43,114,213(+) AGCCA(A/G)ACTGA intron-variant
rs742134 -- 43,122,269(+) GCATG(A/G)GGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BIK Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
nsv459889 CNV Gain 19166990
esv33816 CNV Gain 17666407

Relevant External Links for BIK Gene

HapMap Linkage Disequilibrium report
BIK

Disorders for BIK Gene

(8) Novoseek inferred disease relationships for BIK Gene

Disease -log(P) Hits PubMed IDs
cancer 26.2 9
lymphoma 17 1
lymphoma b-cell 15.3 3
breast cancer 14.3 10
tumors 9.86 13

Relevant External Links for BIK

Genetic Association Database (GAD)
BIK
Human Genome Epidemiology (HuGE) Navigator
BIK
genes like me logo Genes that share disorders with BIK: view

No data available for UniProtKB/Swiss-Prot for BIK Gene

Publications for BIK Gene

  1. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. (PMID: 7478623) Boyd J.M. … Chinnadurai G. (Oncogene 1995) 2 3 4 23
  2. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. (PMID: 8816500) Han J. … White E. (Mol. Cell. Biol. 1996) 3 4 23
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  4. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. (PMID: 8521816) Chittenden T. … Lutz R.J. (EMBO J. 1995) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for BIK Gene

  • Addgene plasmids for BIK

Sources for BIK Gene

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