Aliases for BID Gene
External Ids for BID Gene
Previous GeneCards Identifiers for BID Gene
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for BID Gene
BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Cat Eye Syndrome. Among its related pathways are Activation of BH3-only proteins and Granzyme Pathway. GO annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.
UniProtKB/Swiss-Prot for BID Gene
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.