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Aliases for BID Gene

Aliases for BID Gene

  • BH3 Interacting Domain Death Agonist 2 3
  • P22 BID 3 4
  • BH3-Interacting Domain Death Agonist 3
  • Human BID Coding Sequence 3
  • Apoptic Death Agonist 3
  • BID Isoform ES(1b) 3
  • Desmocollin Type 4 3
  • BID Isoform L(2) 3
  • BID Isoform Si6 3
  • FP497 3

External Ids for BID Gene

Previous GeneCards Identifiers for BID Gene

  • GC22M015157
  • GC22M016591
  • GC22M016592
  • GC22M018216
  • GC22M002030

Summaries for BID Gene

Entrez Gene Summary for BID Gene

  • This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for BID Gene

BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include cat eye syndrome and talipes equinovarus. Among its related pathways are Pathways in cancer and ERK Signaling. GO annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.

UniProtKB/Swiss-Prot for BID Gene

  • The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Gene Wiki entry for BID Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BID Gene

Genomics for BID Gene

Regulatory Elements for BID Gene

Transcription factor binding sites by QIAGEN in the BID gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BID Gene

17,734,138 bp from pter
17,774,770 bp from pter
40,633 bases
Minus strand

Genomic View for BID Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BID Gene

Proteins for BID Gene

  • Protein details for BID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BH3-interacting domain death agonist
    Protein Accession:
    Secondary Accessions:
    • Q549M7
    • Q71T04
    • Q7Z4M9
    • Q8IY86

    Protein attributes for BID Gene

    195 amino acids
    Molecular mass:
    21995 Da
    Quaternary structure:
    • Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH.
    • Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BID Gene

    Alternative splice isoforms for BID Gene


neXtProt entry for BID Gene

Proteomics data for BID Gene at MOPED

Post-translational modifications for BID Gene

  • p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
  • TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.
  • Ubiquitination at Lys158
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BID Gene

Domains for BID Gene

Gene Families for BID Gene


Protein Domains for BID Gene


Graphical View of Domain Structure for InterPro Entry



  • P55957
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family
genes like me logo Genes that share domains with BID: view

Function for BID Gene

Molecular function for BID Gene

GENATLAS Biochemistry:
BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation
UniProtKB/Swiss-Prot Function:
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Gene Ontology (GO) - Molecular Function for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005123 death receptor binding TAS 8918887
GO:0005515 protein binding IPI 12624108
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with BID: view
genes like me logo Genes that share phenotypes with BID: view

Animal Models for BID Gene

MGI Knock Outs for BID:

Animal Model Products

miRNA for BID Gene

miRTarBase miRNAs that target BID

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BID

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BID Gene

Localization for BID Gene

Subcellular locations from UniProtKB/Swiss-Prot for BID Gene

Cytoplasm. Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269 PubMed:14583606}.
BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.
BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. {ECO:0000250}.
Isoform 1: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.

Subcellular locations from

Jensen Localization Image for BID Gene COMPARTMENTS Subcellular localization image for BID gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion TAS 9727491
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane TAS 8918887
genes like me logo Genes that share ontologies with BID: view

Pathways for BID Gene

genes like me logo Genes that share pathways with BID: view

PCR Array Products

Gene Ontology (GO) - Biological Process for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IDA 17052454
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with BID: view

Compounds for BID Gene

(54) Novoseek inferred chemical compound relationships for BID Gene

Compound -log(P) Hits PubMed IDs
ptpc 74.5 2
echinocystic acid 70.4 3
noxa 69.5 5
adpribose 60.8 5
sp 600125 58.7 5
genes like me logo Genes that share compounds with BID: view

Transcripts for BID Gene

Unigene Clusters for BID Gene

BH3 interacting domain death agonist:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BID

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BID Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for BID Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BID Gene

mRNA expression in normal human tissues for BID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BID Gene

This gene is overexpressed in Whole Blood (6.9).

Protein differential expression in normal tissues for BID Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Monocytes (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BID Gene

SOURCE GeneReport for Unigene cluster for BID Gene Hs.591054

mRNA Expression by UniProt/SwissProt for BID Gene

Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
genes like me logo Genes that share expressions with BID: view

Expression partners for BID Gene

In Situ Assay Products

Orthologs for BID Gene

This gene was present in the common ancestor of chordates.

Orthologs for BID Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BID 35
  • 71.87 (n)
  • 59.37 (a)
BID1 36
  • 57 (a)
(Canis familiaris)
Mammalia BID 35
  • 75.77 (n)
  • 68.56 (a)
BID 36
  • 67 (a)
(Mus musculus)
Mammalia Bid 35
  • 75.79 (n)
  • 67.37 (a)
Bid 16
Bid 36
  • 63 (a)
(Pan troglodytes)
Mammalia BID 35
  • 99.45 (n)
  • 100 (a)
BID 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bid 35
  • 73.37 (n)
  • 62.37 (a)
(Monodelphis domestica)
Mammalia BID 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia BID 36
  • 43 (a)
(Gallus gallus)
Aves BID 35
  • 52.02 (n)
  • 42.2 (a)
BID 36
  • 37 (a)
(Anolis carolinensis)
Reptilia BID 36
  • 37 (a)
Species with no ortholog for BID:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BID Gene

Gene Tree for BID (if available)
Gene Tree for BID (if available)

Paralogs for BID Gene

No data available for Paralogs for BID Gene

Variants for BID Gene

Sequence variations from dbSNP and Humsavar for BID Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs11538 -- 17,738,065(-) GTGAA(C/T)TTTAT synonymous-codon, reference
rs25591 -- 17,734,311(-) TCTTT(-/AA/TT)GAGTT utr-variant-3-prime
rs181382 -- 17,735,698(+) AAACA(C/T)GTTCT intron-variant
rs181383 -- 17,735,709(+) CCAGA(C/G)CCCTG intron-variant
rs181384 -- 17,736,276(+) acatg(A/G)gagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BID Gene

Variant ID Type Subtype PubMed ID
nsv526826 CNV Gain 19592680
nsv428385 CNV Gain+Loss 18775914
nsv914151 CNV Gain 21882294
nsv914152 CNV Loss 21882294
nsv834119 CNV Loss 17160897
nsv834120 CNV Loss 17160897
esv2662076 CNV Deletion 23128226
nsv914153 CNV Loss 21882294
dgv4819n71 CNV Loss 21882294

Relevant External Links for BID Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BID Gene

Disorders for BID Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BID Gene in MalaCards »

(2) Diseases for BID Gene including...

(27) Novoseek inferred disease relationships for BID Gene

Disease -log(P) Hits PubMed IDs
necrosis 61.1 8
promyelocytic leukemia 57.9 1
tumors 52.3 18
leukemia 50.9 4
cancer 48.4 5

Relevant External Links for BID

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BID: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for BID Gene

Publications for BID Gene

  1. Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PMID: 14583606) Renshaw S.A. … Whyte M.K. (J. Biol. Chem. 2004) 3 4 23
  2. BID: a novel BH3 domain-only death agonist. (PMID: 8918887) Wang K. … Korsmeyer S.J. (Genes Dev. 1996) 2 3 4
  3. The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PMID: 9721221) Footz T.K. … McDermid H.E. (Genomics 1998) 2 3 4
  4. TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin. (PMID: 19052714) Kim J.G. … Yu W. (Cancer Chemother. Pharmacol. 2009) 3 48
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for BID Gene

  • Addgene plasmids for BID

Sources for BID Gene

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