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BID Gene

protein-coding   GIFtS: 67
GCID: GC22M018216

BH3 Interacting Domain Death Agonist

  See BID-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BH3 Interacting Domain Death Agonist1 2     BID Isoform ES(1b)2
P22 BID2 3     BID Isoform L(2)2
FP4972     BID Isoform Si62
Apoptic Death Agonist2     Desmocollin Type 42
BH3-Interacting Domain Death Agonist2     Human BID Coding Sequence2

External Ids:    HGNC: 10501   Entrez Gene: 6372   Ensembl: ENSG000000154757   OMIM: 6019975   UniProtKB: P559573   

Export aliases for BID gene to outside databases

Previous GC identifers: GC22M015157 GC22M016591 GC22M016592 GC22M002030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BID Gene:
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded
protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage
induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to
mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been
found, but the full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for BID Gene:
BID (BH3 interacting domain death agonist) is a protein-coding gene. Diseases associated with BID include cat eye syndrome, and talipes equinovarus. GO annotations related to this gene include death receptor binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: BID_HUMAN, P55957
Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1,
isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters
the protective effect of Bcl-2

Gene Wiki entry for BID (BH3 interacting-domain death agonist) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_187355.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the BID gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BID promoter sequence
   Search Chromatin IP Primers for BID

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BID


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

BID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BID gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M018216:  view genomic region     (about GC identifiers)

Start:
18,216,906 bp from pter      End:
18,257,536 bp from pter
Size:
40,631 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BID_HUMAN, P55957 (See protein sequence)
Recommended Name: BH3-interacting domain death agonist  
Size: 195 amino acids; 21995 Da
Subunit: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By
similarity). p15 BID interacts with ITCH
Sequence caution: Sequence=AAH22072.2; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for BID:
1ZY3 (3D)        2BID (3D)        2KBW (3D)        2M5B (3D)        2M5I (3D)        4BD2 (3D)    
Secondary accessions: Q549M7 Q71T04 Q7Z4M9 Q8IY86
Alternative splicing: 4 isoforms:  P55957-1   P55957-2   P55957-3   P55957-4   

Explore the universe of human proteins at neXtProt for BID: NX_P55957

Explore proteomics data for BID at MOPED

Post-translational modifications: 

  • TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products (By
    similarity)1
  • p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation1
  • Ubiquitination2 at Lys158
  • Modification sites at PhosphoSitePlus

  • See BID Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001187.1  NP_001231496.1  NP_001231498.1  NP_001231499.1  NP_001231501.1  NP_932070.1  NP_932071.1  

    ENSEMBL proteins: 
     ENSP00000318822   ENSP00000382674   ENSP00000382667   ENSP00000344594   ENSP00000449236  
     ENSP00000382669  
    Reactome Protein details: P55957

    BID Human Recombinant Protein Products:

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    OriGene MassSpec for BID
    OriGene Custom Protein Services for BID
    GenScript Custom Purified and Recombinant Proteins Services for BID
    Novus Biologicals BID Proteins
    Novus Biologicals BID Lysates
    Sino Biological Recombinant Protein for BID
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BID
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for BID 

     
    antibodies-online proteins for BID (56 products) 

     
    antibodies-online peptides for BID

    BID Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BID
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    OriGene Custom Antibody Services for BID
    Novus Biologicals BID Antibodies
    Abcam antibodies for BID
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for BID
    antibodies-online antibodies for BID (254 products) 

    BID Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BID
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BID
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for BID 
    antibodies-online kits for BID (36 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR020728 Bcl2_BH3_motif_CS
     IPR010479 BID

    Graphical View of Domain Structure for InterPro Entry P55957

    ProtoNet protein and cluster: P55957

    UniProtKB/Swiss-Prot: BID_HUMAN, P55957
    Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their
    interaction with anti-apoptotic members of the Bcl-2 family


    Find genes that share domains with BID           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BID_HUMAN, P55957
    Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1,
    isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters
    the protective effect of Bcl-2

         Genatlas biochemistry entry for BID:
    BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and
    liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial
    damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005123death receptor binding TAS8918887
    GO:0005515protein binding IPI12624108
    GO:0031625ubiquitin protein ligase binding IEA--
         
    Find genes that share ontologies with BID           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BID:
     Synthetic lethal with c-Myc af 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Bid):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  no phenotypic analysis  respiratory system  vision/eye 

    Find genes that share phenotypes with BID           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BID: Bidtm1.1Ast Bidtm1Sjk

       genOway: Develop your customized and physiologically relevant rodent model for BID

    miRNA
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    miRTarBase miRNAs that target BID:
    hsa-mir-92a-3p (MIRT049655), hsa-mir-149-5p (MIRT045661)

    Block miRNA regulation of human, mouse, rat BID using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate BID:
    hsa-miR-1297 hsa-miR-3667-5p hsa-miR-124 hsa-miR-649 hsa-miR-26a hsa-miR-506 hsa-miR-590-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidBID 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BID
    Predesigned siRNA for gene silencing in human, mouse, rat BID

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): BID (NM_001196)
    Sino Biological Human cDNA Clone for BID
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BID
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BID
    Addgene plasmids for BID 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BID

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13076) for BID 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BID_HUMAN, P55957: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it
    is predominantly cytoplasmic
    BID_HUMAN, P55957: BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity).
    Note=Translocates to mitochondria as an integral membrane protein (By similarity)
    BID_HUMAN, P55957: BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity).
    Note=Associated with the mitochondrial membrane (By similarity)
    BID_HUMAN, P55957: Isoform 1: Cytoplasm
    BID_HUMAN, P55957: Isoform 3: Cytoplasm
    BID_HUMAN, P55957: Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to
    mitochondria, it may be cleaved constitutively
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion TAS9727491
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--
    GO:0016020membrane TAS8918887

    Find genes that share ontologies with BID           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BID About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    3Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members0.00
    Activation and oligomerization of BAK protein0.00
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    4Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Amyotrophic lateral sclerosis (ALS)0.63
    5Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44


    Find genes that share SuperPaths with BID           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BID
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BID (see all 22)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    DHA Signaling
    Mitochondrial Apoptosis

    1 Cell Signaling Technology (CST) Pathway for BID
        Apoptosis and Autophagy

    5 GeneGo (Thomson Reuters) Pathways for BID
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    Selected BioSystems Pathways for BID (see all 14)
        Apoptosis
    DNA damage response
    Apoptosis Modulation and Signaling
    TP53 network
    Integrated Breast Cancer Pathway

    2 Sino Biological Pathways for BID
        TNF Signaling
    Death Receptor Signaling

    5 Reactome Pathways for BID
        Activation, translocation and oligomerization of BAX
    Activation of BAD and translocation to mitochondria
    Activation, myristolyation of BID and translocation to mitochondria
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    Activation and oligomerization of BAK protein


    Selected Kegg Pathways  (Kegg details for BID) (see all 9):
        p53 signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BID (see all 11): 
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BID

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BID (P559571, 2, 3 ENSP000003188224) via UniProtKB, MINT, STRING, and/or I2D (see all 642)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2L2Q928431, 3, ENSP000002504054EBI-519672,EBI-707714 I2D: score=5 STRING: ENSP00000250405
    YWHABP319462, 3, ENSP000003001614MINT-19326 MINT-24750 I2D: score=3 STRING: ENSP00000300161
    BCL2L2-PABPN1Q928431, 3EBI-519672,EBI-707714 I2D: score=5 
    BAK1Q166111, 3, ENSP000003635914EBI-519672,EBI-519866 I2D: score=3 STRING: ENSP00000363591
    PLEKHM1Q9Y4G22, 3, ENSP000003899134MINT-8249553 I2D: score=2 STRING: ENSP00000389913
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IDA17052454
    GO:0006626protein targeting to mitochondrion IEA--
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IEA--
    GO:0007420brain development IEA--

    Find genes that share ontologies with BID           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BID

    Selected Novoseek inferred chemical compound relationships for BID gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptpc 74.5 2 11175349 (1), 15033708 (1)
    echinocystic acid 70.4 4 15358141 (2), 15246558 (1)
    noxa 69.5 5 17760804 (1), 18794091 (1), 18723481 (1), 20190189 (1) (see all 5)
    adpribose 60.8 5 17142972 (1), 15643515 (1), 20092988 (1), 17301064 (1) (see all 5)
    sp 600125 58.7 5 15117824 (1), 12527812 (1), 15358141 (1), 16609996 (1) (see all 5)
    phosphatidylserine 57.8 4 20107900 (1), 18662577 (1), 19423619 (1)
    suberoylanilide hydroxamic acid 57.3 4 17351739 (2), 12556448 (1), 18765530 (1)
    pd-184352 53.6 3 14645670 (2), 11527401 (1)
    cd 437 50.7 2 15645134 (1), 11156424 (1)
    bortezomib 50.4 4 15767553 (1), 15813915 (1), 17898295 (1), 17351739 (1)



    Find genes that share compounds with BID           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BID gene (7 alternative transcripts): 
    NM_001196.3  NM_001244567.1  NM_001244569.1  NM_001244570.1  NM_001244572.1  NM_197966.2  NM_197967.2  

    Unigene Cluster for BID:

    BH3 interacting domain death agonist
    Hs.591054  [show with all ESTs]
    Unigene Representative Sequence: NM_197966
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317361(uc002znc.2 uc021wko.1 uc010grc.1 uc010grb.1)
    ENST00000399774(uc002znd.2 uc021wkp.1 uc010gra.2) ENST00000399765
    ENST00000494097 ENST00000342111 ENST00000550946 ENST00000551952 ENST00000473439
    ENST00000552886 ENST00000399767(uc002zne.2 uc002znf.2)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate BID:
    hsa-miR-1297 hsa-miR-3667-5p hsa-miR-124 hsa-miR-649 hsa-miR-26a hsa-miR-506 hsa-miR-590-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidBID 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BID
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): BID (NM_001196)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BID
    Addgene plasmids for BID 
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat BID
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    eBioscience FlowRNA Probe Sets ( VA6-13076) for BID 

    Additional mRNA sequence: 

    AF042083.1 AF087891.1 AF250233.1 AF370380.1 AK094795.1 AK313729.1 AY005151.1 BC009197.2 
    BC022072.1 BC033634.1 BC036364.1 CR407603.1 CR456389.1 D89803.1 EU447348.1 EU678292.1 
    EU678293.1 EU678294.1 

    14 DOTS entries:

    DT.110377  DT.100827958  DT.100827974  DT.100827957  DT.120666184  DT.100827973  DT.100844200  DT.100060470 
    DT.100827978  DT.100827960  DT.120666195  DT.91680868  DT.95167822  DT.91640961 

    Selected AceView cDNA sequences (see all 273):

    AI061241 CB108021 H55483 H55504 CR456389 CR612150 BI912781 CA307369 
    NM_197967 BI771303 AI684235 BF194776 CD742890 BM719959 BM789092 AK057062 
    BM992929 BC009197 BI911024 CA426375 CR600376 BI194332 AA360903 BM704321 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BID (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                -                                                                                 
    SP2:                                -                       -                                                         
    SP3:                                                        -                                                         
    SP4:                                -     -                 -                                                         
    SP5:                                -     -                 -                                                         


    ECgene alternative splicing isoforms for BID

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BID expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACAGCGT
    BID Expression
    About this image


    BID expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
    BID Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BID Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591054

    UniProtKB/Swiss-Prot: BID_HUMAN, P55957
    Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex.
    Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung,
    pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BID (see all 11): 
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Atherosclerosis in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BID gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bid1 , 5 BH3 interacting domain death agonist1, 5 75.79(n)1
    67.37(a)1
      6 (57.02 cM)5
    121221  NM_007544.31  NP_031570.21 
     1208919305 
    chicken
    (Gallus gallus)
    Aves BID1 BH3 interacting domain death agonist 52.02(n)
    42.2(a)
      395236  NM_204552.2  NP_989883.2 
    lizard
    (Anolis carolinensis)
    Reptilia BID6
    BH3 interacting domain death agonist
    37(a)
    1 ↔ 1
    5(14064345-14066199)


    ENSEMBL Gene Tree for BID (if available)
    TreeFam Gene Tree for BID (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for BID (see all 1047)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776934121,2
    --18216454(+) TGCCCG/TAGTCA 7 -- ds50010--------
    rs1874459121,2
    --18216464(+) ACCATG/TGCTGG 7 -- ds50010--------
    rs778124631,2
    C,F--18216547(+) GGTGAC/TGGTCT 7 -- ds50011Minor allele frequency- T:0.13WA 118
    rs1922934211,2
    --18216564(+) ACAACC/GAAGAC 7 -- ds50010--------
    rs769843231,2
    --18216720(+) TTAAGA/GACACT 7 -- ds50010--------
    rs1840354091,2
    --18216835(+) GGCGCA/GGTGTG 7 -- ds50010--------
    rs81903621,2
    C,F,H--18216945(-) GCAGTG/ATGGAG 7 -- ut31 ese36Minor allele frequency- A:0.00NS EA CSA 588
    rs81903611,2
    C,F,H--18216951(-) TGCCGC/TGCAGT 7 -- ut31 ese33Minor allele frequency- T:0.01NS NA 348
    rs81903601,2
    C,F,H--18216952(-) CTGCCG/ACGCAG 7 -- ut31 ese311Minor allele frequency- A:0.04NS EA NA WA 1546
    rs81903591,2
    C,F--18217079(-) CTGTTCTTT/-  
            
    AAGAG
    14 -- ut31 cds11Minor allele frequency- -:0.02NS 152

    HapMap Linkage Disequilibrium report for BID (18216906 - 18257536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for BID:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662076CNV Deletion23128226
    nsv914153CNV Loss21882294
    dgv4819n71CNV Loss21882294
    nsv834120CNV Loss17160897
    nsv914152CNV Loss21882294
    nsv834119CNV Loss17160897
    nsv526826CNV Gain19592680
    nsv914151CNV Gain21882294
    nsv428385CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BID
    DNA2.0 Custom Variant and Variant Library Synthesis for BID

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601997    OMIM disorders: --

    2 diseases for BID:    
    About MalaCards
    cat eye syndrome    talipes equinovarus


    Find genes that share disorders with BID           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BID gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 61.1 9 17410536 (1), 20026400 (1), 16380381 (1), 15637055 (1) (see all 8)
    promyelocytic leukemia 57.9 1 15451068 (1)
    tumors 52.3 24 11896568 (3), 15024076 (2), 16787350 (1), 17410536 (1) (see all 15)
    leukemia 50.9 4 15353804 (1), 19820719 (1), 15124184 (1), 16881124 (1)
    cancer 48.4 6 19713356 (1), 11237388 (1), 11896568 (1), 18291090 (1) (see all 5)
    colon cancer 47.5 4 18593990 (2), 16157217 (1), 15024076 (1)
    pancreatic cancer 39.8 1 17410536 (1)
    colon adenocarcinoma 33.3 1 20107900 (1)
    melanoma 30 3 14555232 (1), 15713901 (1), 14667928 (1)
    adenocarcinoma gastric 28.9 3 14716828 (2)

    Genetic Association Database (GAD): BID
    Human Genome Epidemiology (HuGE) Navigator: BID (76 documents)

    Export disorders for BID gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BID gene, integrated from 10 sources (see all 586):
    (articles sorted by number of sources associating them with BID)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PubMed id 9721221)1, 2, 3 Footz T.K.... McDermid H.E. (Genomics 1998)
    2. BID: a novel BH3 domain-only death agonist. (PubMed id 8918887)1, 2, 3 Wang K.... Korsmeyer S.J. (Genes Dev. 1996)
    3. Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PubMed id 14583606)1, 2, 9 Renshaw S.A.... Whyte M.K. (J. Biol. Chem. 2004)
    4. Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (PubMed id 17534194)1, 4, 9 Ester A.R....Hecht J.T. (Clin. Orthop. Relat. Res. 2007)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. (PubMed id 20392206)1, 2 Azakir B.A.... Angers A. (FEBS J. 2010)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    10. TNF superfamily gene polymorphism as prognostic factor in early breast cancer. (PubMed id 19890662)1, 4 Jung J.H....Park H.Y. (J. Cancer Res. Clin. Oncol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 637 HGNC: 1050 AceView: BID Ensembl:ENSG00000015475 euGenes: HUgn637
    ECgene: BID Kegg: 637 H-InvDB: BID

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BID Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BID Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bid/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BID gene:
    Search GeneIP for patents involving BID

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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