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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BID Gene

protein-coding   GIFtS: 67
GCID: GC22M018216

BH3 Interacting Domain Death Agonist

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BH3 Interacting Domain Death Agonist1 2     BID Isoform ES(1b)2
P22 BID2 3     BID Isoform L(2)2
FP4972     BID Isoform Si62
Apoptic Death Agonist2     Desmocollin Type 42
BH3-Interacting Domain Death Agonist2     Human BID Coding Sequence2

External Ids:    HGNC: 10501   Entrez Gene: 6372   Ensembl: ENSG000000154757   OMIM: 6019975   UniProtKB: P559573   

Export aliases for BID gene to outside databases

Previous GC identifers: GC22M015157 GC22M016591 GC22M016592 GC22M002030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BID Gene:
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded
protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage
induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to
mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been
found, but the full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for BID Gene: 
BID (BH3 interacting domain death agonist) is a protein-coding gene. Diseases associated with BID include 22q11.2 duplication, and hereditary mucosal leukokeratosis, and among its related super-pathways are DR3 Signaling and Parkinson's disease. GO annotations related to this gene include death receptor binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: BID_HUMAN, P55957
Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1,
isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters
the protective effect of Bcl-2

Gene Wiki entry for BID (BH3 interacting-domain death agonist) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011519.10  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BID gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BID promoter sequence
   Search SABiosciences Chromatin IP Primers for BID

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BID


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

BID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BID gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M018216:  view genomic region     (about GC identifiers)

Start:
18,216,906 bp from pter      End:
18,257,536 bp from pter
Size:
40,631 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BID_HUMAN, P55957 (See protein sequence)
Recommended Name: BH3-interacting domain death agonist  
Size: 195 amino acids; 21995 Da
Subunit: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By
similarity). p15 BID interacts with ITCH
Subcellular location: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it
is predominantly cytoplasmic
Subcellular location: BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity).
Note=Translocates to mitochondria as an integral membrane protein (By similarity)
Subcellular location: BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity).
Note=Associated with the mitochondrial membrane (By similarity)
Subcellular location: Isoform 1: Cytoplasm
Subcellular location: Isoform 3: Cytoplasm
Subcellular location: Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to
mitochondria, it may be cleaved constitutively
Sequence caution: Sequence=AAH22072.2; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for BID:
1ZY3 (3D)        2BID (3D)        2KBW (3D)        2M5B (3D)        4BD2 (3D)    
Secondary accessions: Q549M7 Q71T04 Q7Z4M9 Q8IY86
Alternative splicing: 4 isoforms:  P55957-1   P55957-2   P55957-3   P55957-4   

Explore the universe of human proteins at neXtProt for BID: NX_P55957

Explore proteomics data for BID at MOPED 

Post-translational modifications:

  • UniProtKB: TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products (By
    similarity)
  • UniProtKB: p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55957

  • BID Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BID Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001187.1  NP_001231496.1  NP_001231498.1  NP_001231499.1  NP_001231501.1  NP_932070.1  NP_932071.1  

    ENSEMBL proteins: 
     ENSP00000318822   ENSP00000382674   ENSP00000382667   ENSP00000344594   ENSP00000449236  
     ENSP00000382669  
    Reactome Protein details: P55957
    Human Recombinant Protein Products for BID: 
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    OriGene MassSpec for BID 
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    Novus Biologicals BID Proteins
    Novus Biologicals BID Lysates
    Sino Biological Recombinant Protein for BID
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    ProSpec Recombinant Protein for BID
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion TAS9727491
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--
    GO:0016020membrane TAS8918887

    BID for ontologies           About GeneDecksing



    BID Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR020728 Bcl2_BH3_motif_CS
     IPR010479 BID

    Graphical View of Domain Structure for InterPro Entry P55957

    ProtoNet protein and cluster: P55957

    UniProtKB/Swiss-Prot: BID_HUMAN, P55957
    Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their
    interaction with anti-apoptotic members of the Bcl-2 family


    BID for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BID_HUMAN, P55957
    Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1,
    isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters
    the protective effect of Bcl-2

         Genatlas biochemistry entry for BID:
    BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and
    liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial
    damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005123death receptor binding TAS8918887
    GO:0005515protein binding IPI12624108
    GO:0031625ubiquitin protein ligase binding IEA--
         
    BID for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BID:
     Synthetic lethal with c-Myc af 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Bid):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  no phenotypic analysis  respiratory system  vision/eye 

    BID for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BID: Bidtm1.1Ast Bidtm1Sjk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BID 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BID

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BID 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BID 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BID
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate BID:
    hsa-miR-1297 hsa-miR-3667-5p hsa-miR-124 hsa-miR-649 hsa-miR-26a hsa-miR-506 hsa-miR-590-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidBID 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Validated adenovirus to knockdown BID in human, mouse 
                         Customized adenovirus for overexpression of BID

    Clone
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    OriGene ORF clones in mouse, rat for BID
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    GenScript: all cDNA clones in your preferred vector (see all 3): BID (NM_001196)
    Sino Biological Human cDNA Clone for BID
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BID
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                         Customized lentivirus expression plasmids for stable overexpression of BID 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BID


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BID About   (see all 33)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Non-alcoholic fatty liver disease (NAFLD)0.41
    Alzheimers Disease0.44
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival Caspase cascade0.44
    4p53 signaling pathway
    p53 signaling pathway0.41
    DNA damage response0.41
    514-3-3 Induced Apoptosis
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for BID
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival Apoptotic TNF-family pathways

    1 R&D Systems Pathway for BID
        Apoptosis Signaling Pathways

    5/22 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BID (see all 22)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    DHA Signaling
    Mitochondrial Apoptosis

    1 Cell Signaling Technology (CST) Pathway for BID
        Apoptosis and Autophagy

    5 GeneGo (Thomson Reuters) Pathways for BID
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    5/13 BioSystems Pathways for BID (see all 13)
        DNA damage response
    Apoptosis
    Apoptosis Modulation and Signaling
    TP53 network
    Integrated Breast Cancer Pathway

    2 Sino Biological Pathways for BID 
        TNF Signaling
    Death Receptor Signaling

    5/8        Reactome Pathways for BID (see all 8)
        Activation of BH3-only proteins
    Activation, translocation and oligomerization of BAX
    Activation of BAD and translocation to mitochondria
    Activation and oligomerization of BAK protein
    Apoptosis


    5/9         Kegg Pathways  (Kegg details for BID) (see all 9):
        p53 signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    BID for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BID

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/640 Interacting proteins for BID (P559571, 2, 3 ENSP000003188224) via UniProtKB, MINT, STRING, and/or I2D (see all 640)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2L2Q928431, 3, ENSP000002504054EBI-519672,EBI-707714 I2D: score=5 STRING: ENSP00000250405
    YWHABP319462, 3, ENSP000003001614MINT-19326 MINT-24750 I2D: score=3 STRING: ENSP00000300161
    BCL2L2-PABPN1Q928431, 3EBI-519672,EBI-707714 I2D: score=5 
    PLEKHM1Q9Y4G22, 3, ENSP000003899134MINT-8249553 I2D: score=2 STRING: ENSP00000389913
    C14orf1Q9UKR52, 3MINT-8249476 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IDA17052454
    GO:0006626protein targeting to mitochondrion IEA--
    GO:0006915apoptotic process TAS--
    GO:0007420brain development IEA--
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors TAS9727491

    BID for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BID for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BID

    10/54 Novoseek inferred chemical compound relationships for BID gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptpc 74.5 2 11175349 (1), 15033708 (1)
    echinocystic acid 70.4 4 15358141 (2), 15246558 (1)
    noxa 69.5 5 17760804 (1), 18794091 (1), 18723481 (1), 20190189 (1) (see all 5)
    adpribose 60.8 5 17142972 (1), 15643515 (1), 20092988 (1), 17301064 (1) (see all 5)
    sp 600125 58.7 5 15117824 (1), 12527812 (1), 15358141 (1), 16609996 (1) (see all 5)
    phosphatidylserine 57.8 4 20107900 (1), 18662577 (1), 19423619 (1)
    suberoylanilide hydroxamic acid 57.3 4 17351739 (2), 12556448 (1), 18765530 (1)
    pd-184352 53.6 3 14645670 (2), 11527401 (1)
    cd 437 50.7 2 15645134 (1), 11156424 (1)
    bortezomib 50.4 4 15767553 (1), 15813915 (1), 17898295 (1), 17351739 (1)

    Search CenterWatch for drugs/clinical trials and news about BID

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BID gene (7 alternative transcripts): 
    NM_001196.3  NM_001244567.1  NM_001244569.1  NM_001244570.1  NM_001244572.1  NM_197966.2  NM_197967.2  

    Unigene Cluster for BID:

    BH3 interacting domain death agonist
    Hs.591054  [show with all ESTs]
    Unigene Representative Sequence: NM_197966
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317361(uc002znc.2 uc021wko.1 uc010grc.1 uc010grb.1)
    ENST00000399774(uc002znd.2 uc021wkp.1 uc010gra.2) ENST00000399765
    ENST00000494097 ENST00000342111 ENST00000550946 ENST00000551952 ENST00000473439
    ENST00000552886 ENST00000399767(uc002zne.2 uc002znf.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BID
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BID

    Additional mRNA sequence: 

    AF042083.1 AF087891.1 AF250233.1 AF370380.1 AK094795.1 AK313729.1 AY005151.1 BC009197.2 
    BC022072.1 BC033634.1 BC036364.1 CR407603.1 CR456389.1 D89803.1 EU447348.1 EU678292.1 
    EU678293.1 EU678294.1 

    14 DOTS entries:

    DT.110377  DT.100827958  DT.100827974  DT.100827957  DT.120666184  DT.100827973  DT.100844200  DT.100060470 
    DT.100827978  DT.100827960  DT.120666195  DT.91680868  DT.95167822  DT.91640961 

    24/273 AceView cDNA sequences (see all 273):

    BI771303 BU607848 CR600376 BQ575545 BC009197 CR611157 NM_197967 NM_197966 
    BG696745 AI061241 CR612150 AK057062 R09537 AI282959 H55504 BX375832 
    AI251761 AI911421 H55483 NM_001196 BI918273 AI521499 CB108021 CR407603 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BID (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                -                                                                                 
    SP2:                                -                       -                                                         
    SP3:                                                        -                                                         
    SP4:                                -     -                 -                                                         
    SP5:                                -     -                 -                                                         


    ECgene alternative splicing isoforms for BID

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BID expression in normal human tissues (normalized intensities)      BID embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACAGCGT
    BID Expression
    About this image


    BID expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Epiphyseal End
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocytes   
     
     Neuron (Nervous System)
             nerve   

    See BID Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BID

    SOURCE GeneReport for Unigene cluster: Hs.591054

    UniProtKB/Swiss-Prot: BID_HUMAN, P55957
    Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex.
    Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung,
    pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including BID (see all 11): 
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Atherosclerosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BID gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bid1 , 5 BH3 interacting domain death agonist1, 5 74.48(n)1
    66.15(a)1
      6 (57.02 cM)5
    121221  NM_007544.31  NP_031570.21 
     1208919305 
    chicken
    (Gallus gallus)
    Aves BID1 BH3 interacting domain death agonist 51.65(n)
    41.76(a)
      395236  NM_204552.2  NP_989883.2 
    lizard
    (Anolis carolinensis)
    Reptilia BID6
    Uncharacterized protein
    36(a)
    1 ↔ 1
    5(14064345-14066199)


    ENSEMBL Gene Tree for BID (if available)
    TreeFam Gene Tree for BID (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1047 SNPs in BID are shown (see all 1047)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776934121,2
    --18216454(+) TGCCCG/TAGTCA 7 -- ds50010--------
    rs1874459121,2
    --18216464(+) ACCATG/TGCTGG 7 -- ds50010--------
    rs778124631,2
    C,F--18216547(+) GGTGAC/TGGTCT 7 -- ds50011Minor allele frequency- T:0.13WA 118
    rs1922934211,2
    --18216564(+) ACAACC/GAAGAC 7 -- ds50010--------
    rs769843231,2
    --18216720(+) TTAAGA/GACACT 7 -- ds50010--------
    rs1840354091,2
    --18216835(+) GGCGCA/GGTGTG 7 -- ds50010--------
    rs81903621,2
    C,F,H--18216945(-) GCAGTG/ATGGAG 7 -- ut31 ese36Minor allele frequency- A:0.00NS EA CSA 588
    rs81903611,2
    C,F,H--18216951(-) TGCCGC/TGCAGT 7 -- ut31 ese33Minor allele frequency- T:0.01NS NA 348
    rs81903601,2
    C,F,H--18216952(-) CTGCCG/ACGCAG 7 -- ut31 ese311Minor allele frequency- A:0.04NS EA NA WA 1546
    rs81903591,2
    C,F--18217079(-) CTGTTCTTT/-  
            
    AAGAG
    14 -- ut31 cds11Minor allele frequency- -:0.02NS 152

    HapMap Linkage Disequilibrium report for BID (18216906 - 18257536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for BID:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662076CNV Deletion23128226
    nsv914153CNV Loss21882294
    dgv4819n71CNV Loss21882294
    nsv834120CNV Loss17160897
    nsv914152CNV Loss21882294
    nsv834119CNV Loss17160897
    nsv526826CNV Gain19592680
    nsv914151CNV Gain21882294
    nsv428385CNV Gain+Loss18775914

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BID

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601997    OMIM disorders: --

    20/62 diseases for BID (see all 62):    About MalaCards
    22q11.2 duplication    hereditary mucosal leukokeratosis    talipes equinovarus    clubfoot
    cervical cancer    gastric adenocarcinoma    mantle cell lymphoma    hepatitis c
    protein s deficiency    amyotrophic lateral sclerosis    lateral sclerosis    hepatoblastoma
    cervicitis    myocarditis    burkitt's lymphoma    wilms tumor
    adenocarcinoma    gastric cancer    pancreatic cancer    rhabdomyosarcoma


    BID for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/27 Novoseek inferred disease relationships for BID gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 61.1 9 17410536 (1), 20026400 (1), 16380381 (1), 15637055 (1) (see all 8)
    promyelocytic leukemia 57.9 1 15451068 (1)
    tumors 52.3 24 11896568 (3), 15024076 (2), 16787350 (1), 17410536 (1) (see all 15)
    leukemia 50.9 4 15353804 (1), 19820719 (1), 15124184 (1), 16881124 (1)
    cancer 48.4 6 19713356 (1), 11237388 (1), 11896568 (1), 18291090 (1) (see all 5)
    colon cancer 47.5 4 18593990 (2), 16157217 (1), 15024076 (1)
    pancreatic cancer 39.8 1 17410536 (1)
    colon adenocarcinoma 33.3 1 20107900 (1)
    melanoma 30 3 14555232 (1), 15713901 (1), 14667928 (1)
    adenocarcinoma gastric 28.9 3 14716828 (2)

    Genetic Association Database (GAD): BID
    Human Genome Epidemiology (HuGE) Navigator: BID (76 documents)

    Export disorders for BID gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BID gene, integrated from 9 sources (see all 580):
    (articles sorted by number of sources associating them with BID)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PubMed id 9721221)1, 2, 3 Footz T.K.... McDermid H.E. (1998)
    2. BID: a novel BH3 domain-only death agonist. (PubMed id 8918887)1, 2, 3 Wang K.... Korsmeyer S.J. (1996)
    3. Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PubMed id 14583606)1, 2, 9 Renshaw S.A.... Whyte M.K. (2004)
    4. Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (PubMed id 17534194)1, 4, 9 Ester A.R....Hecht J.T. (2007)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    8. The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degrada tion of the truncated C-terminal portion of Bid. (PubMed id 20392206)1, 2 Azakir B.A....Angers A. (2010)
    9. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    10. TNF superfamily gene polymorphism as prognostic facto r in early breast cancer. (PubMed id 19890662)1, 4 Jung J.H....Park H.Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 637 HGNC: 1050 AceView: BID Ensembl:ENSG00000015475 euGenes: HUgn637
    ECgene: BID Kegg: 637 H-InvDB: BID

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BID Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BID Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bid/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BID gene:
    Search GeneIP for patents involving BID

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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