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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BID Gene

protein-coding GIFtS: 65
GCID: GC22M018216

BH3 interacting domain death agonist

Explore 64 diseases affiliated with
BID via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BH3 Interacting Domain Death Agonist¹ ²		BID Isoform ES(1b)²
P22 BID² ³		BID Isoform L(2)²
FP497²		BID Isoform Si6²
Apoptic Death Agonist²		Desmocollin Type 4²
BH3-Interacting Domain Death Agonist²		Human BID Coding Sequence²

External Ids:	HGNC: 1050¹	Entrez Gene: 637²	Ensembl: ENSG00000015475⁷	OMIM: 601997⁵	UniProtKB: P55957³

Export aliases for BID gene to outside databases

Previous GC identifers: GC22M015157 GC22M016591 GC22M016592 GC22M002030

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BID:

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein

is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by

caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where

it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the

full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BID_HUMAN, P55957

Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform

2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective

effect of Bcl-2

Gene Wiki entry for BID (BH3 interacting-domain death agonist)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011519.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BID gene promoter:
ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BID promoter sequence

Search SABiosciences Chromatin IP Primers for BID

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BID

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.2

BID Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BID gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M018216: view genomic region (about GC identifiers)

Start:	18,216,906 bp from pter	End:	18,257,536 bp from pter
Size:	40,631 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BID_HUMAN, P55957 (See protein sequence)

Recommended Name: BH3-interacting domain death agonist

Size: 195 amino acids; 21995 Da

Subunit: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By

similarity). p15 BID interacts with ITCH

Subcellular location: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it is

predominantly cytoplasmic

Subcellular location: BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity).

Note=Translocates to mitochondria as an integral membrane protein (By similarity)

Subcellular location: BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Note=Associated

with the mitochondrial membrane (By similarity)

Subcellular location: Isoform 1: Cytoplasm

Subcellular location: Isoform 3: Cytoplasm

Subcellular location: Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to

mitochondria, it may be cleaved constitutively

Sequence caution: Sequence=AAH22072.2; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for BID:

1ZY3 (3D)

2BID (3D)

2KBW (3D)

4BD2 (3D)

Secondary accessions: Q549M7 Q71T04 Q7Z4M9 Q8IY86

Alternative splicing: 4 isoforms: P55957-1 P55957-2 P55957-3 P55957-4

Explore the universe of human proteins at neXtProt for BID: NX_P55957

Post-translational modifications:

TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products (By

similarity)¹

p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55957

BID Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001187.1 NP_001231496.1 NP_001231498.1 NP_001231499.1 NP_001231501.1 NP_932070.1 NP_932071.1

ENSEMBL proteins:

ENSP00000318822 ENSP00000382674 ENSP00000382667 ENSP00000344594 ENSP00000449236

ENSP00000382669

Reactome Protein details: P55957
Human Recombinant Protein Products for BID:

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	Enzo Life Sciences proteins for BID
	OriGene Purified Protein: BID OriGene Protein Over-expression Lysate (see all 3): BID OriGene Custom Protein Services for BID
	GenScript Custom Purified and Recombinant Proteins Services for BID
	Novus Biologicals BID Proteins Novus Biologicals BID Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for BID
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	TAS	9727491
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0005829	cytosol	TAS	--

BID for ontologies About GeneDecksing

BID Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BID
	R&D Systems Antibodies for BID
	OriGene Antibodies (see all 4): BID OriGene Custom Antibody Services for BID
	GenScript Superior Antibodies for BID
	Novus Biologicals BID Antibodies
	Abcam antibodies for BID
	Browse Antibodies at Uscn
	ThermoFisher Antibody for BID

Assay Products for BID:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for BID
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BID for domains About GeneDecksing

2 InterPro domains/families:

IPR020728 Bcl2_BH3_motif_CS

IPR010479 BID

Graphical View of Domain Structure for InterPro Entry P55957

ProtoNet protein and cluster: P55957

UniProtKB/Swiss-Prot: BID_HUMAN, P55957

Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their

interaction with anti-apoptotic members of the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: BID_HUMAN, P55957

Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform

2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective

effect of Bcl-2

Genatlas biochemistry entry for BID:

BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing

with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8

cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005123	death receptor binding	TAS	8918887
GO:0005515	protein binding	IPI	--
GO:0031625	ubiquitin protein ligase binding	IEA	--

BID for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for BID:

Synthetic lethal with c-Myc af

14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Bid):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	muscle
nervous system	no phenotypic analysis	respiratory system	vision/eye

BID for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for BID: Bid^tm1.1Ast Bid^tm1Sjk

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BID

miRNA Products:		OriGene 3'-UTR Clone (see all 3): BID Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BID
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate BID:
		hsa-miR-1297 hsa-miR-3667-5p hsa-miR-124 hsa-miR-649 hsa-miR-26a hsa-miR-506 hsa-miR-590-3p hsa-miR-26b

		SwitchGear 3'UTR luciferase reporter plasmid: BID 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BID (see all 7) OriGene shRNA RFP: BID OriGene siRNA: BID
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BID
		Sirion Biotech Custom design and validation of potent shRNA sequences against BID

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for BID
			Sirion Biotech Customized adenovirus for overexpression of BID Sirion Biotech Customized adenovirus for potent knockdown of BID

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BID (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BID (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): BID (NM_001196)
		Sino Biological Human cDNA Clone for BID
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BID
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BID

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BID
		Search LifeMap BioReagents cell lines for BID
		Sirion Biotech Customized stable knockdown cell line services for BID Sirion Biotech Customized inducible knockdown cell line services for BID Sirion Biotech Customized stable overexpressing cell line services for BID Sirion Biotech Customized inducible overexpressing cell line services for BID

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BID

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TWEAK Pathway

8/12 pathways (see all 12)
TWEAK Pathway	1.00	TRAIL Pathway	0.40
DR3 Signaling	0.87	TNF Signaling	0.40
TNFR1 Pathway	0.53	Apoptotic Pathways Triggered By HIV1	0.37
HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	Apoptosis through Death Receptors	0.32

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1.00	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins	0.24
Activation of BH3-only proteins	0.30	Intrinsic Pathway for Apoptosis	0.23
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	0.24	Activation of BAD and translocation to mitochondria	0.15

Apoptosis and survival_Caspase cascade

Apoptosis and survival_Caspase cascade	1.00	Apoptosis and survival FAS signaling cascades	0.44
Apoptosis and survival Caspase cascade	1.00	Caspase cascade in apoptosis	0.42
Apoptosis and survival_FAS signaling cascades	0.44

Apoptotic Pathways in Synovial Fibroblasts

	p53 Mediated Apoptosis	0.84			DHA Signaling	0.70
	Mitochondrial Apoptosis	0.73			Cellular Apoptosis Pathway	0.65

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival_Apoptotic TNF-family pathways	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for BID

	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
	Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for BID

Apoptosis Signaling Pathways

5/22 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BID (see all 22)

	Caspase Cascade
	TWEAK Pathway
	14-3-3 Induced Apoptosis
	DHA Signaling
	Mitochondrial Apoptosis

1 Cell Signaling Technology (CST) Pathway for BID

Apoptosis and Autophagy

5 GeneGo (Thomson Reuters) Pathways for BID

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

5/14 BioSystems Pathways for BID (see all 14)

	DNA damage response
	Apoptosis
	Apoptosis Modulation and Signaling
	TP53 network
	Integrated Breast Cancer Pathway

5/8 Reactome Pathways for BID (see all 8)

	Activation of BH3-only proteins
	Activation, translocation and oligomerization of BAX
	Activation of BAD and translocation to mitochondria
	Activation and oligomerization of BAK protein
	Apoptosis

5/8 Kegg Pathways (Kegg details for BID) (see all 8):

	p53 signaling pathway
	Apoptosis
	Natural killer cell mediated cytotoxicity
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)

BID for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BID

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/601 Interacting proteins for BID (P55957^{1, 2, 3} ENSP00000318822⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 601)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL2L2	Q92843¹^,³, ENSP00000250405⁴	EBI-519672,EBI-707714 I2D: score=5 STRING: ENSP00000250405
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-19326 MINT-24750 I2D: score=3 STRING: ENSP00000300161
BCL2L2-PABPN1	Q92843¹^,³	EBI-519672,EBI-707714 I2D: score=5
PLEKHM1	Q9Y4G2²^,³, ENSP00000389913⁴	MINT-8249553 I2D: score=2 STRING: ENSP00000389913
C14orf1	Q9UKR5²^,³	MINT-8249476 I2D: score=2

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001836	release of cytochrome c from mitochondria	IDA	17052454
GO:0006626	protein targeting to mitochondrion	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0007420	brain development	IEA	--
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	TAS	9727491

BID for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BID for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BID
10/54 Novoseek chemical compound relationships for BID gene (see all 54) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ptpc	74.5	2	11175349 (1), 15033708 (1)
echinocystic acid	70.4	4	15358141 (2), 15246558 (1)
noxa	69.5	5	17760804 (1), 18794091 (1), 18723481 (1), 20190189 (1) (see all 5)
adpribose	60.8	5	17142972 (1), 15643515 (1), 20092988 (1), 17301064 (1) (see all 5)
sp 600125	58.7	5	15117824 (1), 12527812 (1), 15358141 (1), 16609996 (1) (see all 5)
phosphatidylserine	57.8	4	20107900 (1), 18662577 (1), 19423619 (1)
suberoylanilide hydroxamic acid	57.3	4	17351739 (2), 12556448 (1), 18765530 (1)
pd-184352	53.6	3	14645670 (2), 11527401 (1)
cd 437	50.7	2	15645134 (1), 11156424 (1)
bortezomib	50.4	4	15767553 (1), 15813915 (1), 17898295 (1), 17351739 (1)

Search CenterWatch for drugs/clinical trials and news about BID

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BID gene (7 alternative transcripts):

NM_001196.3 NM_001244567.1 NM_001244569.1 NM_001244570.1 NM_001244572.1 NM_197966.2 NM_197967.2

Unigene Cluster for BID:

BH3 interacting domain death agonist

Hs.591054 [show with all ESTs]

Unigene Representative Sequence: NM_197966

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000317361(uc002znc.2 uc021wko.1 uc010grc.1 uc010grb.1)

ENST00000399774(uc002znd.2 uc021wkp.1 uc010gra.2) ENST00000399765

ENST00000494097 ENST00000342111 ENST00000550946 ENST00000551952 ENST00000473439

ENST00000552886 ENST00000399767(uc002zne.2 uc002znf.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): BID Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BID
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate BID:
		hsa-miR-1297 hsa-miR-3667-5p hsa-miR-124 hsa-miR-649 hsa-miR-26a hsa-miR-506 hsa-miR-590-3p hsa-miR-26b

		SwitchGear 3'UTR luciferase reporter plasmid: BID 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BID (see all 7) OriGene shRNA RFP: BID OriGene siRNA: BID
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BID
		Sirion Biotech Custom design and validation of potent shRNA sequences against BID

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BID (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BID (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): BID (NM_001196)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BID
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BID

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BID Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BID
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BID
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BID

Additional cDNA sequence:

AF042083.1 AF087891.1 AF250233.1 AF370380.1 AK094795.1 AK313729.1 AY005151.1 BC009197.2

BC022072.1 BC033634.1 BC036364.1 CR407603.1 CR456389.1 D89803.1 EU447348.1 EU678292.1

EU678293.1 EU678294.1

14 DOTS entries:

DT.110377 DT.100827958 DT.100827974 DT.100827957 DT.120666184 DT.100827973 DT.100844200 DT.100060470

DT.100827978 DT.100827960 DT.120666195 DT.91680868 DT.95167822 DT.91640961

24/273 AceView cDNA sequences (see all 273):

H55483 AK057062 CR600376 AA338833 BU168412 NM_197967 BI912781 BG696745

R09537 AA835976 BX375832 CA450254 BI911024 BC009197 CB852500 BF194776

BF515349 AI872099 BM044443 AI061241 BM704321 AI684235 H55504 BM789092

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BID (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f
SP1:											-
SP2:											-								-
SP3:																			-
SP4:											-		-						-
SP5:											-		-						-

ECgene alternative splicing isoforms for BID

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BID expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAACAGCGT

About this image

BID expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Bone

Zeugopod Periosteum

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BID Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BID

SOURCE GeneReport for Unigene cluster: Hs.591054

UniProtKB/Swiss-Prot: BID_HUMAN, P55957

Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex.

Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas

and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including BID (see all 11):

Autophagy in human mouse rat

Liver Cancer in human mouse rat

Apoptosis in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

Atherosclerosis in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BID gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bid^{1 , 5}	BH3 interacting domain death agonist^{1, 5}	74.48(n)¹ 66.15(a)¹		6 (57.02 cM)⁵ 12122¹ NM_007544.3¹ NP_031570.2¹ 120891930⁵
chicken (Gallus gallus)	Aves	BID¹	BH3 interacting domain death agonist	51.65(n) 41.76(a)		395236 NM_204552.2 NP_989883.2
lizard (Anolis carolinensis)	Reptilia	BID⁶	--	37(a)	1 ↔ 1	5(14064345-14066199)

ENSEMBL Gene Tree for BID (if available)
TreeFam Gene Tree for BID (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8190258^1,2	C	--	2072537(-)	`tgaggC/ACTGGT`	1	--	us2k¹		2		NS WA	288
rs8190257^1,2	C	--	2072538(-)	`gtgagG/ACCTGG`	1	--	us2k¹		2		NS WA	288
rs8190256^1,2	C,F	--	2072545(-)	`AAATGA/CAGTGA`	1	--	us2k¹		5		NS NA WA EA	530
rs8190255^1,2	C	--	2072580(-)	`GTAGTA/GTGTCA`	1	--	us2k¹		2		NS WA	288
rs8190254^1,2	C,F,H	--	2072677(-)	`CCCAGC/ACCGAG`	1	--	us2k¹		17		NS EA NA WA	1802
rs5992827^1,2	C,F	--	2072765(+)	`GAAGAC/TGAAAG`	1	--	us2k¹ tfbs³		9		NS CSA WA	828
rs8190253^1,2	C,F	--	2072773(-)	`AAGTTT/GCCCTT`	1	--	us2k¹ tfbs³ trp³		4		NS WA CSA	292
rs8190252^1,2	C	--	2072907(-)	`CGCCTG/ACCCTG`	1	--	us2k¹		1		NS	170
rs77693412^1,2		--	18216454(+)	`TGCCCG/TAGTCA`	7	--	ds500¹		0	--	--	--	--
rs187445912^1,2		--	18216464(+)	`ACCATG/TGCTGG`	7	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BID (18216906 - 18257536 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BID
1 CNV: 5167

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BID for disorders           About GeneDecksing

OMIM gene information: 601997    OMIM disorders: --

20/64 diseases for BID (see all 64):    About MalaCards

hereditary mucosal leukokeratosis amyotrophic lateral sclerosis (als) talipes equinovarus amyotrophic lateral sclerosis

cat eye syndrome non-hodgkin lymphoma lateral sclerosis mantle cell lymphoma

hodgkin's lymphoma chronic lymphocytic leukemia hepatitis c herpes simplex

lymphocytic leukemia burkitt's lymphoma clubfoot wilms tumor

adenocarcinoma multiple myeloma hepatocellular carcinoma cervical cancer

10/27 Novoseek disease relationships for BID gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	61.1	9	17410536 (1), 20026400 (1), 16380381 (1), 15637055 (1) (see all 8)
promyelocytic leukemia	57.9	1	15451068 (1)
tumors	52.3	24	11896568 (3), 15024076 (2), 16787350 (1), 17410536 (1) (see all 15)
leukemia	50.9	4	15353804 (1), 19820719 (1), 15124184 (1), 16881124 (1)
cancer	48.4	6	19713356 (1), 11237388 (1), 11896568 (1), 18291090 (1) (see all 5)
colon cancer	47.5	4	18593990 (2), 16157217 (1), 15024076 (1)
pancreatic cancer	39.8	1	17410536 (1)
colon adenocarcinoma	33.3	1	20107900 (1)
melanoma	30	3	14555232 (1), 15713901 (1), 14667928 (1)
adenocarcinoma gastric	28.9	3	14716828 (2)

Human Genome Epidemiology (HuGE) Navigator: BID (76 documents)

Export disorders for BID gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BID gene, integrated from 9 sources (see all 570):
(articles sorted by number of sources associating them with BID)

Utopia: connect your pdf to the dynamic
world of online information

The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PubMed id 9721221)^{1, 2, 3} Footz T.K.... McDermid H.E. (1998)
BID: a novel BH3 domain-only death agonist. (PubMed id 8918887)^{1, 2, 3} Wang K.... Korsmeyer S.J. (1996)
Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PubMed id 14583606)^{1, 2, 9} Renshaw S.A.... Whyte M.K. (2004)
The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degrada tion of the truncated C-terminal portion of Bid. (PubMed id 20392206)^{1, 2} Azakir B.A....Angers A. (2010)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Solution structure of BID, an intracellular amplifier of apoptotic signaling. (PubMed id 10089877)^{1, 2} Chou J.J.... Wagner G. (1999)
Cleavage of bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells. (PubMed id 19233849)^{1, 9} Shelton S.N....Robertson J.D. (2009)
Effect of Helicobacter pylori infection on expression of Bcl-2 family members in gastric adenocarcinoma. (PubMed id 14716828)^{1, 9} Zhang H....Luo Y.H. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 637	HGNC: 1050	AceView: BID	Ensembl:ENSG00000015475	euGenes: HUgn637
ECgene: BID	Kegg: 637	H-InvDB: BID

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BID	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BID	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/bid/

Intellectual Property for BID gene
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Patent Information for BID gene:
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GeneCards and IP:
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BH3 interacting domain death agonist

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