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Aliases for BICRAL Gene

Aliases for BICRAL Gene

  • BRD4 Interacting Chromatin Remodeling Complex Associated Protein Like 2 3 5
  • KIAA0240 2 3 4
  • Glioma Tumor Suppressor Candidate Region Gene 1 Protein-Like 3 4
  • GLTSCR1 Like 2 3
  • GLTSCR1L 3 4
  • BRD4 Interacting Chromatin Remodelling Complex Associated Protein Like 3
  • BRD4-Interacting Chromatin-Remodeling Complex-Associated Protein-Like 3
  • GLTSCR1-Like 2

External Ids for BICRAL Gene

Previous HGNC Symbols for BICRAL Gene

  • KIAA0240
  • GLTSCR1L

Summaries for BICRAL Gene

GeneCards Summary for BICRAL Gene

BICRAL (BRD4 Interacting Chromatin Remodeling Complex Associated Protein Like) is a Protein Coding gene. An important paralog of this gene is BICRA.

Additional gene information for BICRAL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BICRAL Gene

Genomics for BICRAL Gene

Regulatory Elements for BICRAL Gene

Enhancers for BICRAL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043087 1.6 Ensembl ENCODE dbSUPER 47.2 +344.2 344243 7.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 SP5 NFYC ZC3H11A REST ZNF318 ABCC10 CUL7 POLR1C RPS2P29 POLH XPO5 GTPBP2 BICRAL ENSG00000271970
GH06H042780 1.4 ENCODE dbSUPER 45.5 +37.1 37134 7.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 CUL7 ABCC10 ZNF318 BICRAL GTPBP2 POLH POLR1C RPS2P29 RPL34P14 XPO5
GH06H043701 1.6 Ensembl ENCODE dbSUPER 38 +955.9 955942 3.2 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZBTB7B ZNF766 FOS SP3 ZNF318 POLH GTPBP2 BICRAL XPO5 CDC5L POLR1C RPS2P29 ABCC10 CUL7
GH06H043723 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +978.0 977950 2.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 ZBTB7B GTPBP2 POLH ZNF318 ABCC10 BICRAL RPS2P29 RRP36 MAD2L1BP VEGFA MRPS18A
GH06H043624 1.4 ENCODE dbSUPER 21.6 +881.1 881081 7.4 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 POLH GTPBP2 ZNF318 ABCC10 RRP36 RPS2P29 CUL7 XPO5 POLR1C ENSG00000271754
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BICRAL on UCSC Golden Path with GeneCards custom track

Promoters for BICRAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197043 -458 3401 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Locations for BICRAL Gene

Genomic Locations for BICRAL Gene
chr6:42,746,958-42,868,560
(GRCh38/hg38)
Size:
121,603 bases
Orientation:
Plus strand
chr6:42,749,765-42,836,298
(GRCh37/hg19)

Genomic View for BICRAL Gene

Genes around BICRAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICRAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICRAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICRAL Gene

Proteins for BICRAL Gene

  • Protein details for BICRAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AI39-BICRL_HUMAN
    Recommended name:
    BRD4-interacting chromatin-remodeling complex-associated protein-like
    Protein Accession:
    Q6AI39
    Secondary Accessions:
    • A1L3W2
    • Q5TFZ3
    • Q92514

    Protein attributes for BICRAL Gene

    Size:
    1079 amino acids
    Molecular mass:
    115084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13246.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for BICRAL Gene

Post-translational modifications for BICRAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICRAL Gene

No data available for DME Specific Peptides for BICRAL Gene

Domains & Families for BICRAL Gene

Gene Families for BICRAL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BICRAL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BICRAL: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BICRAL Gene

Function for BICRAL Gene

Phenotypes From GWAS Catalog for BICRAL Gene

genes like me logo Genes that share phenotypes with BICRAL: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BICRAL Gene

Localization for BICRAL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICRAL gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BICRAL Gene

Pathways & Interactions for BICRAL Gene

SuperPathways for BICRAL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICRAL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BICRAL Gene

Drugs & Compounds for BICRAL Gene

No Compound Related Data Available

Transcripts for BICRAL Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BICRAL Gene

No ASD Table

Relevant External Links for BICRAL Gene

GeneLoc Exon Structure for
BICRAL
ECgene alternative splicing isoforms for
BICRAL

Expression for BICRAL Gene

NURSA nuclear receptor signaling pathways regulating expression of BICRAL Gene:

BICRAL
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICRAL Gene

Orthologs for BICRAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for BICRAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLTSCR1L 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia GLTSCR1L 33 34
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia GLTSCR1L 33 34
  • 90.93 (n)
rat
(Rattus norvegicus)
Mammalia Gltscr1l 33
  • 86.91 (n)
mouse
(Mus musculus)
Mammalia Gltscr1l 33 34
  • 85.53 (n)
Bicral 16
oppossum
(Monodelphis domestica)
Mammalia GLTSCR1L 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLTSCR1L 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0240 33
  • 76.39 (n)
GLTSCR1L 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLTSCR1L 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr1l 33
  • 61.43 (n)
zebrafish
(Danio rerio)
Actinopterygii gltscr1l 33 34
  • 55.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToMany
Species where no ortholog for BICRAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICRAL Gene

ENSEMBL:
Gene Tree for BICRAL (if available)
TreeFam:
Gene Tree for BICRAL (if available)

Paralogs for BICRAL Gene

Paralogs for BICRAL Gene

genes like me logo Genes that share paralogs with BICRAL: view

Variants for BICRAL Gene

Sequence variations from dbSNP and Humsavar for BICRAL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs193921035 Uncertain significance 42,830,111(+) TTCCA(A/G)GTCTA nc-transcript-variant, reference, missense
rs1000032114 -- 42,761,050(+) CAAAT(A/G/T)AAAAA intron-variant
rs1000038181 -- 42,855,127(+) TGCCT(C/T)GTTAG intron-variant
rs1000050543 -- 42,769,688(+) CACCG(A/G)CCTTC intron-variant
rs1000087928 -- 42,820,826(+) CAGCC(A/G)CCAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BICRAL Gene

Variant ID Type Subtype PubMed ID
nsv958388 CNV deletion 24416366
nsv830651 CNV loss 17160897
nsv830650 CNV loss 17160897
nsv433480 CNV loss 18776910
nsv1017398 CNV gain 25217958
esv3608805 CNV loss 21293372
esv3576145 CNV gain 25503493
esv2668024 CNV deletion 23128226

Variation tolerance for BICRAL Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BICRAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BICRAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICRAL Gene

Disorders for BICRAL Gene

Relevant External Links for BICRAL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BICRAL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BICRAL

No disorders were found for BICRAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BICRAL Gene

Publications for BICRAL Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for BICRAL Gene

Sources for BICRAL Gene

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