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Aliases for BICRA Gene

Aliases for BICRA Gene

  • BRD4 Interacting Chromatin Remodeling Complex Associated Protein 2 3
  • GLTSCR1 3 4 5
  • Glioma Tumor Suppressor Candidate Region Gene 1 2 5
  • BRD4 Interacting Chromatin Remodelling Complex Associated Protein 3
  • Glioma Tumor Suppressor Candidate Region Gene 1 Protein 3

External Ids for BICRA Gene

Previous HGNC Symbols for BICRA Gene

  • GLTSCR1

Summaries for BICRA Gene

GeneCards Summary for BICRA Gene

BICRA (BRD4 Interacting Chromatin Remodeling Complex Associated Protein) is a Protein Coding gene. An important paralog of this gene is BICRAL.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BICRA Gene

Genomics for BICRA Gene

Regulatory Elements for BICRA Gene

Enhancers for BICRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G047242 2.1 FANTOM5 Ensembl ENCODE dbSUPER 66.2 -364.4 -364406 2.5 CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 SLC1A5 ENSG00000268746 EHD2 INAFM1 PRKD2
GH19G047225 1.5 ENCODE dbSUPER 81.7 -378.8 -378815 8.2 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZC3H4 BICRA ENSG00000268810 NOP53-AS1 CCDC9 PPP5D1 PRKD2 SLC1A5 ENSG00000268746 SNORD23
GH19G047239 2 FANTOM5 Ensembl ENCODE dbSUPER 52.8 -367.6 -367637 3.1 CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZC3H4 BICRA NOP53-AS1 ENSG00000268810 PPP5D1 C19orf68 CCDC9 SLC8A2 SLC1A5 ENSG00000268746
GH19G046638 1.4 ENCODE dbSUPER 48.5 -968.8 -968848 2.4 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 BICRA ZC3H4 CCDC61 IRF2BP1 ENSG00000268810 ENSG00000269148 FBXO46 CCDC9 ENSG00000268746 SLC1A5
GH19G046727 1.8 FANTOM5 Ensembl ENCODE 36.8 -876.8 -876838 6.9 MLX DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 SSRP1 GLIS1 ZC3H4 ENSG00000268810 CCDC61 BICRA PRKD2 STRN4 ENSG00000259605 IRF2BP1 ENSG00000268746 MIR320E
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BICRA on UCSC Golden Path with GeneCards custom track

Promoters for BICRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110585 1004 3201 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for BICRA Gene

Chromosome:
19
Start:
47,608,196 bp from pter
End:
47,703,277 bp from pter
Size:
95,082 bases
Orientation:
Plus strand

Genomic View for BICRA Gene

Genes around BICRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICRA Gene

Proteins for BICRA Gene

  • Protein details for BICRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZM4-GSCR1_HUMAN
    Recommended name:
    Glioma tumor suppressor candidate region gene 1 protein
    Protein Accession:
    Q9NZM4
    Secondary Accessions:
    • A8MW01

    Protein attributes for BICRA Gene

    Size:
    1560 amino acids
    Molecular mass:
    158490 Da
    Quaternary structure:
    • Interacts with BRD4.
    SequenceCaution:
    • Sequence=AAF62874.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BICRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BICRA Gene

Post-translational modifications for BICRA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICRA Gene

No data available for DME Specific Peptides for BICRA Gene

Domains & Families for BICRA Gene

Protein Domains for BICRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BICRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BICRA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BICRA Gene

Function for BICRA Gene

Gene Ontology (GO) - Molecular Function for BICRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with BICRA: view
genes like me logo Genes that share phenotypes with BICRA: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BICRA Gene

Localization for BICRA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICRA gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BICRA Gene

Pathways & Interactions for BICRA Gene

SuperPathways for BICRA Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICRA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BICRA Gene

Drugs & Compounds for BICRA Gene

No Compound Related Data Available

Transcripts for BICRA Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BICRA Gene

No ASD Table

Relevant External Links for BICRA Gene

GeneLoc Exon Structure for
BICRA
ECgene alternative splicing isoforms for
BICRA

Expression for BICRA Gene

NURSA nuclear receptor signaling pathways regulating expression of BICRA Gene:

BICRA

mRNA Expression by UniProt/SwissProt for BICRA Gene:

Q9NZM4-GSCR1_HUMAN
Tissue specificity: Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.

Evidence on tissue expression from TISSUES for BICRA Gene

  • Nervous system(2.4)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICRA Gene

Orthologs for BICRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BICRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLTSCR1 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia GLTSCR1 34 35
  • 88.62 (n)
rat
(Rattus norvegicus)
Mammalia Gltscr1 34
  • 82.43 (n)
mouse
(Mus musculus)
Mammalia Gltscr1 34 35
  • 82.37 (n)
Bicra 16
cow
(Bos Taurus)
Mammalia GLTSCR1 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC101749950 34
  • 72.69 (n)
GLTSCR1 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLTSCR1 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr1 34
  • 63.16 (n)
zebrafish
(Danio rerio)
Actinopterygii gltscr1 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for BICRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICRA Gene

ENSEMBL:
Gene Tree for BICRA (if available)
TreeFam:
Gene Tree for BICRA (if available)

Paralogs for BICRA Gene

Paralogs for BICRA Gene

Pseudogenes.org Pseudogenes for BICRA Gene

genes like me logo Genes that share paralogs with BICRA: view

Variants for BICRA Gene

Sequence variations from dbSNP and Humsavar for BICRA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000016718 -- 47,628,619(+) GGAGT(A/T)TGGGG intron-variant
rs1000028890 -- 47,637,272(+) CCGCC(A/C)CCACA intron-variant
rs1000034120 -- 47,665,887(+) AGATA(A/C)ACACA intron-variant
rs1000052849 -- 47,669,817(+) ACGCC(C/T)GGCTA intron-variant
rs1000063398 -- 47,663,879(+) CTTCC(A/T)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BICRA Gene

Variant ID Type Subtype PubMed ID
dgv1790n106 CNV deletion 24896259
dgv6506n54 CNV loss 21841781
dgv6507n54 CNV loss 21841781
esv23734 CNV loss 19812545
esv3556494 CNV deletion 23714750
esv3644556 CNV loss 21293372
esv3644557 CNV loss 21293372
nsv1059189 CNV gain 25217958
nsv1114018 CNV deletion 24896259
nsv1143922 CNV deletion 24896259
nsv521727 CNV loss 19592680
nsv579888 CNV gain 21841781
nsv579889 CNV loss 21841781
nsv953592 CNV deletion 24416366
nsv953593 CNV deletion 24416366

Variation tolerance for BICRA Gene

Gene Damage Index Score: 10.72; 91.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BICRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BICRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICRA Gene

Disorders for BICRA Gene

Relevant External Links for BICRA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BICRA

No disorders were found for BICRA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BICRA Gene

Publications for BICRA Gene

  1. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S. … Howley P.M. (Mol. Cell. Biol. 2011) 2 3 4 64
  2. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3 64

Products for BICRA Gene

Sources for BICRA Gene

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