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Aliases for BICDL2 Gene

Aliases for BICDL2 Gene

  • BICD Family Like Cargo Adaptor 2 2 3 5
  • Coiled-Coil Domain-Containing Protein 64B 3 4
  • Coiled-Coil Domain Containing 64B 2 3
  • Bicaudal D-Related Protein 2 3 4
  • BICD-Related Protein 2 3 4
  • CCDC64B 3 4
  • BICDR-2 3 4
  • BICDR2 3 4
  • BICD Family-Like Cargo Adapter 2 3

External Ids for BICDL2 Gene

Previous HGNC Symbols for BICDL2 Gene

  • CCDC64B

Summaries for BICDL2 Gene

GeneCards Summary for BICDL2 Gene

BICDL2 (BICD Family Like Cargo Adaptor 2) is a Protein Coding gene. An important paralog of this gene is BICDL1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BICDL2 Gene

Genomics for BICDL2 Gene

Regulatory Elements for BICDL2 Gene

Enhancers for BICDL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G003019 1.4 ENCODE dbSUPER 30.2 +14.7 14661 5.2 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 SP3 BICDL2 ZNF174 ZNF205 TIGD7 ZNF597 MTRNR2L4 CLUAP1 ZNF263 SNHG19 ERVK13-1
GH16G003027 1.2 Ensembl ENCODE 32.4 +8.5 8527 1.3 PKNOX1 AGO1 ARID4B SIN3A ZNF48 GTF3C2 GLIS2 ZNF143 SP3 SP5 BICDL2 TRAF7 THOC6 LOC105371055 CREBBP SNORD60 ZNF263 LOC100128770 HCFC1R1
GH16G003052 1.5 Ensembl ENCODE dbSUPER 22.6 -17.5 -17474 3.7 HDGF ATF1 DMAP1 GLIS2 ELK1 ZNF207 ZNF518A ZNF592 ZNF579 ZNF610 MMP25 BICDL2 IL32 CLDN6 TNFRSF12A ZNF205 CLDN9 PKMYT1 GC16P003092
GH16G003017 1.1 Ensembl ENCODE 24.9 +19.0 19048 1.8 HDGF PKNOX1 ATF1 ZSCAN4 RAD21 ETS1 EGR1 CREM EGR2 THAP11 BICDL2 LOC107984895 TNFRSF12A CLDN9
GH16G003069 2 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -37.4 -37417 9.8 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 THOC6 HCFC1R1 CLDN6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BICDL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BICDL2 Gene

3,027,682 bp from pter
3,036,963 bp from pter
9,282 bases
Minus strand

Genomic View for BICDL2 Gene

Genes around BICDL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICDL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICDL2 Gene

Proteins for BICDL2 Gene

  • Protein details for BICDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BICD family-like cargo adapter 2
    Protein Accession:
    Secondary Accessions:
    • Q658L9

    Protein attributes for BICDL2 Gene

    508 amino acids
    Molecular mass:
    56834 Da
    Quaternary structure:
    • Interacts with RAB13.

    Alternative splice isoforms for BICDL2 Gene


neXtProt entry for BICDL2 Gene

Post-translational modifications for BICDL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICDL2 Gene

No data available for DME Specific Peptides for BICDL2 Gene

Domains & Families for BICDL2 Gene

Protein Domains for BICDL2 Gene


Suggested Antigen Peptide Sequences for BICDL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BICDR family.
  • Belongs to the BICDR family.
genes like me logo Genes that share domains with BICDL2: view

No data available for Gene Families for BICDL2 Gene

Function for BICDL2 Gene

Gene Ontology (GO) - Molecular Function for BICDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with BICDL2: view

Phenotypes for BICDL2 Gene

GenomeRNAi human phenotypes for BICDL2:
genes like me logo Genes that share phenotypes with BICDL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BICDL2 Gene

Localization for BICDL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICDL2 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BICDL2 Gene

Pathways & Interactions for BICDL2 Gene

SuperPathways for BICDL2 Gene

No Data Available

Interacting Proteins for BICDL2 Gene

Gene Ontology (GO) - Biological Process for BICDL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for BICDL2 Gene

Drugs & Compounds for BICDL2 Gene

No Compound Related Data Available

Transcripts for BICDL2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BICDL2 Gene

No ASD Table

Relevant External Links for BICDL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BICDL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BICDL2 Gene:


Evidence on tissue expression from TISSUES for BICDL2 Gene

  • Stomach(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICDL2 Gene

Orthologs for BICDL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BICDL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC64B 34 35
  • 99.34 (n)
(Canis familiaris)
Mammalia CCDC64B 34 35
  • 86.34 (n)
(Bos Taurus)
Mammalia CCDC64B 34 35
  • 85.08 (n)
(Rattus norvegicus)
Mammalia Ccdc64b 34
  • 82.21 (n)
(Mus musculus)
Mammalia Ccdc64b 34 35
  • 80.96 (n)
Bicdl2 16
(Monodelphis domestica)
Mammalia CCDC64B 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC64B 35
  • 56 (a)
(Anolis carolinensis)
Reptilia CCDC64B 35
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc64b 34
  • 50.47 (n)
(Danio rerio)
Actinopterygii CCDC64B 35
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32137 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
CSA.2341 35
  • 18 (a)
Species where no ortholog for BICDL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICDL2 Gene

Gene Tree for BICDL2 (if available)
Gene Tree for BICDL2 (if available)

Paralogs for BICDL2 Gene

Paralogs for BICDL2 Gene

genes like me logo Genes that share paralogs with BICDL2: view

Variants for BICDL2 Gene

Sequence variations from dbSNP and Humsavar for BICDL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000024355 -- 3,036,078(+) CTGAG(C/T)AGGTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000028770 -- 3,032,511(+) TCAAG(C/T)AGCTT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000308899 -- 3,036,969(+) TGCGG(C/T)CAACA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000447187 -- 3,032,401(+) TATCT(C/T)TAAGT intron-variant, upstream-variant-2KB
rs1000525687 -- 3,036,758(+) TCCTG(-/CCGGCGCCCCCGGTTCC)CCGGC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BICDL2 Gene

Variant ID Type Subtype PubMed ID
esv2763127 CNV loss 21179565
esv3637645 CNV gain 21293372
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for BICDL2 Gene

Gene Damage Index Score: 15.77; 97.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BICDL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICDL2 Gene

Disorders for BICDL2 Gene

Relevant External Links for BICDL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BICDL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BICDL2 Gene

Publications for BICDL2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64

Products for BICDL2 Gene

Sources for BICDL2 Gene

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