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BICD2 Gene

protein-coding   GIFtS: 55
GCID: GC09M095473

Bicaudal D Homolog 2 (Drosophila)

  See BICD2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bicaudal D Homolog 2 (Drosophila)1 2     Coiled-Coil Protein BICD22
Bic-D 22 3     Cytoskeleton-Like Bicaudal D Protein Homolog 22
SMALED22 5     Homolog Of Drosophila Bicaudal D2
KIAA06993 5     Protein Bicaudal D Homolog 22
bA526D8.12     

External Ids:    HGNC: 172081   Entrez Gene: 232992   Ensembl: ENSG000001859637   OMIM: 6097975   UniProtKB: Q8TD163   

Export aliases for BICD2 gene to outside databases

Previous GC identifers: GC09M086300 GC09M087201 GC09M088772 GC09M090815 GC09M090816 GC09M092553 GC09M094513 GC09M065151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BICD2 Gene:
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been
implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a
phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. (provided
by RefSeq, Jul 2008)

GeneCards Summary for BICD2 Gene:
BICD2 (bicaudal D homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with BICD2 include spinal muscular atrophy, lower extremity-predominant, 2, ad, and proximal spinal muscular atrophy. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is BICD1.

UniProtKB/Swiss-Prot: BICD2_HUMAN, Q8TD16
Function: May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by
associating with these complexes. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic
reticulum transport by recruiting the dynein-dynactin motor complex (By similarity)

Gene Wiki entry for BICD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the BICD2 gene promoter:
         NF-YA   NF-YC   CBF-C   NF-YB   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBICD2 promoter sequence
   Search Chromatin IP Primers for BICD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BICD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.32

BICD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BICD2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095473:  view genomic region     (about GC identifiers)

Start:
95,473,645 bp from pter      End:
95,527,094 bp from pter
Size:
53,450 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BICD2_HUMAN, Q8TD16 (See protein sequence)
Recommended Name: Protein bicaudal D homolog 2  
Size: 824 amino acids; 93533 Da
Subunit: Interacts with DCTN2 and RAB6A. Interacts with NEK9. Interacts with DNAI1
Sequence caution: Sequence=BAA31674.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O75181 Q5TBQ2 Q5TBQ3 Q96LH2 Q9BT84 Q9H561
Alternative splicing: 2 isoforms:  Q8TD16-1   Q8TD16-2   (Due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BICD2: NX_Q8TD16

Explore proteomics data for BICD2 at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK9 in vitro1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BICD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003800.1  NP_056065.1  

    ENSEMBL proteins: 
     ENSP00000349351   ENSP00000364662  

    BICD2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for BICD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018477 Bicaudal-D_microtubule-assoc

    Graphical View of Domain Structure for InterPro Entry Q8TD16

    ProtoNet protein and cluster: Q8TD16

    UniProtKB/Swiss-Prot: BICD2_HUMAN, Q8TD16
    Domain: The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2 (By
    similarity)
    Similarity: Belongs to the BicD family


    Find genes that share domains with BICD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BICD2_HUMAN, Q8TD16
    Function: May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by
    associating with these complexes. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic
    reticulum transport by recruiting the dynein-dynactin motor complex (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16417406
    GO:0017137Rab GTPase binding ISS--
         
    Find genes that share ontologies with BICD2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BICD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BICD2

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    miRNA
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    miRTarBase miRNAs that target BICD2:
    hsa-mir-193b-3p (MIRT041505), hsa-mir-615-3p (MIRT039848), hsa-mir-1301-3p (MIRT035982), hsa-mir-32-5p (MIRT028312), hsa-mir-766-3p (MIRT039040), hsa-mir-124-3p (MIRT023191)

    Block miRNA regulation of human, mouse, rat BICD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BICD2 (see all 90):
    hsa-miR-411* hsa-miR-193a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-93 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidBICD2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BICD2_HUMAN, Q8TD16: Golgi apparatus. Cytoplasm, cytoskeleton. Note=In interphase cells mainly localizes to the
    Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Its localization is
    dependent on microtubule morphology
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane4
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IDA--
    GO:0031410cytoplasmic vesicle ISS--

    Find genes that share ontologies with BICD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BICD2
    Interactions:

        GeneGlobe Interaction Network for BICD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BICD2 (Q8TD163 ENSP000003493514) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN2Q135613, ENSP000004089104I2D: score=3 STRING: ENSP00000408910
    DCTN1Q142033, ENSP000003547914I2D: score=2 STRING: ENSP00000354791
    ZRANB1Q9UGI03, ENSP000003526764I2D: score=2 STRING: ENSP00000352676
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    NEK8Q86SG63, ENSP000002687664I2D: score=1 STRING: ENSP00000268766
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007018microtubule-based movement ----
    GO:0008219cell death IEA--
    GO:0072385minus-end-directed organelle transport along microtubule ISS--
    GO:0072393microtubule anchoring at microtubule organizing center ISS--

    Find genes that share ontologies with BICD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BICD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BICD2 gene (2 alternative transcripts): 
    NM_001003800.1  NM_015250.3  

    Unigene Cluster for BICD2:

    Bicaudal D homolog 2 (Drosophila)
    Hs.436939  [show with all ESTs]
    Unigene Representative Sequence: BC073970
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356884(uc004asp.1) ENST00000375512(uc004aso.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat BICD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BICD2 (see all 90):
    hsa-miR-411* hsa-miR-193a-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-578 hsa-miR-519a hsa-miR-93 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidBICD2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): BICD2 (NM_015250)
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      QuantiTect SYBR Green Assays in human, mouse, rat BICD2
      QuantiFast Probe-based Assays in human, mouse, rat BICD2

    Additional mRNA sequence: 

    AB014599.1 AY052562.1 BC004296.1 BC010428.1 BC073970.1 

    6 DOTS entries:

    DT.97803436  DT.80100690  DT.121188556  DT.100815322  DT.91914250  DT.99976382 

    Selected AceView cDNA sequences (see all 246):

    BU626377 AI749971 AI092772 BF448351 BE619516 AW409827 BF476723 BX282018 
    AW131261 AI813427 AY052562 AI138873 BU172964 BM969877 BQ773177 AI805959 
    CD365354 AA621608 CA439423 AI824023 BU839273 BU689841 BG697058 BX504523 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BICD2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      


    ECgene alternative splicing isoforms for BICD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BICD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGGAAT
    BICD2 Expression
    About this image


    BICD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    BICD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BICD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436939

    UniProtKB/Swiss-Prot: BICD2_HUMAN, Q8TD16
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BICD2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bicd21 , 5 bicaudal D homolog 2 (Drosophila)1, 5 90.11(n)1
    95.64(a)1
      13 (25.22 cM)5
    768951  NM_001039179.21  NP_001034268.11 
     493415495 
    chicken
    (Gallus gallus)
    Aves BICD21 bicaudal D homolog 2 (Drosophila) 75.39(n)
    82.58(a)
      415990  XM_004944558.1  XP_004944615.1 
    lizard
    (Anolis carolinensis)
    Reptilia BICD26
    bicaudal D homolog 2 (Drosophila)
    82(a)
    1 ↔ 1
    GL343225.1(2235799-2290863)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.269432 Xenopus laevis transcribed sequence with weak similarity more 75.13(n)    BU914482.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5573831 protein bicaudal D homolog 2-like 67.41(n)
    70.58(a)
      557383  XM_005155890.1  XP_005155947.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BicD1 , 3 egg chamber formation3
    Bicaudal D1
    38(a)3
    53.99(n)1
    45.04(a)1
      2 36C93
    350511  NM_001273602.11  NP_001260531.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C43G2.23
    bicd-11
    cytoskeleton-like protein3
    bicd-11
    30(a)3
    43.94(n)1
    39.23(a)1
      IV(6566088-6572516)3
    1834171  NM_068600.11  NP_501001.11 


    ENSEMBL Gene Tree for BICD2 (if available)
    TreeFam Gene Tree for BICD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BICD2 gene
    BICD12  
    1 SIMAP similar gene for BICD2 using alignment to 2 protein entries:     BICD2_HUMAN (see all proteins):
    BICD1

    Find genes that share paralogs with BICD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BICD2 (see all 1140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0701174
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701172 T M mis40--------
    VAR_0701124
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701122 S L mis40--------
    VAR_0701164
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701162 K T mis40--------
    VAR_0701134
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701132 N T mis40--------
    VAR_0701144
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701142 I F mis40--------
    VAR_0701154
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701152 R P mis40--------
    VAR_0701184
    Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2)4--see VAR_0701182 E G mis40--------
    rs132865661,2
    C,F,A--95473178(+) TCTTAC/TCAACA 2 -- ds500113Minor allele frequency- T:0.39NA WA CSA EA 514
    rs789445061,2
    C,F--95473248(+) GAGGCG/ATCAGG 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1461112811,2
    C--95473280(+) TCCAGG/TGGGGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for BICD2 (95473645 - 95527094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BICD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999632CNV Deletion20482838
    nsv6616CNV Insertion18451855

    Human Gene Mutation Database (HGMD): BICD2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609797   
    OMIM disorders: 615290  
    UniProtKB/Swiss-Prot: BICD2_HUMAN, Q8TD16
  • Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant (SMALED2) [MIM:615290]: An
    autosomal dominant form of spinal muscular atrophy characterized by early-childhood onset of muscle weakness and
    atrophy predominantly affecting the proximal and distal muscles of the lower extremity, although some patients
    may show upper extremity involvement. The disorder results in delayed walking, waddling gait, difficulty walking,
    and loss of distal reflexes. Some patients may have foot deformities or hyperlordosis, and some show mild upper
    motor signs, such as spasticity. Sensation, bulbar function, and cognitive function are preserved. The disorder
    shows very slow progression throughout life. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 2 diseases for BICD2:    
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    spinal muscular atrophy, lower extremity-predominant, 2, ad    proximal spinal muscular atrophy


    Find genes that share disorders with BICD2           About GenesLikeMe


    Export disorders for BICD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BICD2 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with BICD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PubMed id 11864968)1, 2, 9 Holland P.M.... Virca G.D. (J. Biol. Chem. 2002)
    3. Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy. (PubMed id 23664116)1, 2 Neveling K....Wirth B. (Am. J. Hum. Genet. 2013)
    4. Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia. (PubMed id 23664120)1, 2 Oates E.C....Reilly M.M. (Am. J. Hum. Genet. 2013)
    5. Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance. (PubMed id 23664119)1, 2 Peeters K....Jordanova A. (Am. J. Hum. Genet. 2013)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23299 HGNC: 17208 AceView: BICD2 Ensembl:ENSG00000185963 euGenes: HUgn23299
    ECgene: BICD2 H-InvDB: BICD2

    (According to HUGE)
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    HUGE: KIAA0699

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BICD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BICD2 gene:
    Search GeneIP for patents involving BICD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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