Aliases for BICD2 Gene
External Ids for BICD2 Gene
Previous GeneCards Identifiers for BICD2 Gene
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for BICD2 Gene
BICD2 (BICD Cargo Adaptor 2) is a Protein Coding gene. Diseases associated with BICD2 include Spinal Muscular Atrophy, Lower Extremity-Predominant, 2, Ad and Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy With Contractures. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is BICD1.
UniProtKB/Swiss-Prot for BICD2 Gene
May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (By similarity).