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BICC1 Gene

protein-coding   GIFtS: 50
GCID: GC10P060272

BicC Family RNA Binding Protein 1

(Previous name: bicaudal C homolog 1 (Drosophila))
  See BICC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BicC Family RNA Binding Protein 11 2     Bicaudal C Homolog 12
BICC2 5     FGFR2-BICC1 Fusion Kinase Protein2
CYSRD2 5     Protein Bicaudal C Homolog 12
Bicaudal C Homolog 1 (Drosophila)1     Bic-C3
bic-C2     

External Ids:    HGNC: 193511   Entrez Gene: 801142   Ensembl: ENSG000001228707   OMIM: 6142955   UniProtKB: Q9H6943   

Export aliases for BICC1 gene to outside databases

Previous GC identifers: GC10P059348 GC10P059578 GC10P060445 GC10P059897 GC10P060223 GC10P054263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BICC1 Gene:
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein
translation during embryonic development. Mouse studies identified the corresponding protein to be under strict
control during cell differentiation and to be a maternally provided gene product. (provided by RefSeq, Apr 2009)

GeneCards Summary for BICC1 Gene:
BICC1 (BicC family RNA binding protein 1) is a protein-coding gene. Diseases associated with BICC1 include renal dysplasia, cystic, and renal dysplasia. GO annotations related to this gene include RNA binding. An important paralog of this gene is HDLBP.

UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694
Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in
regulating gene expression during embryonic development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BICC1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Ik-3   HNF-1A   Nkx3-1 v2   SRY   HNF-1   FOXO1a   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for BICC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BICC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q21.3

BICC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BICC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P060272:  view genomic region     (about GC identifiers)

Start:
60,272,900 bp from pter      End:
60,591,195 bp from pter
Size:
318,296 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694 (See protein sequence)
Recommended Name: Protein bicaudal C homolog 1  
Size: 974 amino acids; 104844 Da
Subunit: Interacts (via KH domains) with ANKS6 (via SAM domain) in an RNA-dependent manner (By similarity)
Sequence caution: Sequence=BAB15369.1; Type=Erroneous initiation;
Alternative splicing: 2 isoforms:  Q9H694-1   Q9H694-2   

Explore the universe of human proteins at neXtProt for BICC1: NX_Q9H694

Explore proteomics data for BICC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BICC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073981.1  
    ENSEMBL proteins: 
     ENSP00000362993   ENSP00000263103  

    BICC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BICC1

     
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    LSBio Antibodies in human, mouse, rat for BICC1

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    Cloud-Clone Corp. CLIAs for BICC1
    Search eBioscience for ELISAs for BICC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR021129 SAM_type1
     IPR004087 KH_dom
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q9H694

    ProtoNet protein and cluster: Q9H694

    UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694
    Similarity: Belongs to the BicC family
    Similarity: Contains 2 KH domains
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with BICC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BICC1_HUMAN, Q9H694
    Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in
    regulating gene expression during embryonic development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with BICC1           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Bicc1):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with BICC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bicc1tm1Bdc for BICC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BICC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BICC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BICC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BICC1

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    hsa-miR-9 hsa-miR-133a hsa-miR-133b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BICC1_HUMAN, Q9H694: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with BICC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BICC1
    Interactions:

        Search GeneGlobe Interaction Network for BICC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BICC1 (Q9H6943 ENSP000003629934) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KHDRBS1Q076663, ENSP000003138294I2D: score=1 STRING: ENSP00000313829
    QKIQ96PU83, ENSP000003549514I2D: score=1 STRING: ENSP00000354951
    IPO13O948293I2D: score=5 
    PAPLNO954283I2D: score=5 
    KIAA1429Q69YN43I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0090090negative regulation of canonical Wnt signaling pathway IDA--

    Find genes that share ontologies with BICC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BICC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BICC1 gene: 
    NM_001080512.1  

    Unigene Cluster for BICC1:

    Bicaudal C homolog 1 (Drosophila)
    Hs.158745  [show with all ESTs]
    Unigene Representative Sequence: NM_001080512
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373886(uc001jki.1) ENST00000476684 ENST00000263103(uc001jkj.1)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate BICC1:
    hsa-miR-9 hsa-miR-133a hsa-miR-133b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BICC1
      QuantiTect SYBR Green Assays in human, mouse, rat BICC1
      QuantiFast Probe-based Assays in human, mouse, rat BICC1

    Additional mRNA sequence: 

    AK026129.1 AK225427.1 AK225429.1 AK307780.1 AY726586.1 

    2 DOTS entries:

    DT.97806694  DT.97818140 

    9 AceView cDNA sequences:

    AA424272 BX282230 BG751458 BX538102 AI242865 AK026129 AI375513 BM972104 
    BG163356 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BICC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  


    ECgene alternative splicing isoforms for BICC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BICC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCTGACT
    BICC1 Expression
    About this image


    BICC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             Visceral White Adipose
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
    BICC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BICC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158745
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BICC1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bicc11 , 5 bicaudal C homolog 1 (Drosophila)1, 5 86.17(n)1
    93.12(a)1
      10 (36.75 cM)5
    836751  NM_031397.21  NP_113574.11 
     709228325 
    chicken
    (Gallus gallus)
    Aves BICC11 bicaudal C homolog 1 (Drosophila) 82.2(n)
    89.9(a)
      423604  NM_001199507.1  NP_001186436.1 
    lizard
    (Anolis carolinensis)
    Reptilia BICC16
    bicaudal C homolog 1 (Drosophila)
    75(a)
    1 ↔ 1
    GL343251.1(1009300-1160188)
    African clawed frog
    (Xenopus laevis)
    Amphibia Bic-C2 bicaudal-C 76.32(n)    AF224746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5682011 protein bicaudal C homolog 1-like 64.66(n)
    67.43(a)
      568201  XM_691516.5  XP_696608.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta BicC6
    Bicaudal C
    30(a)
    1 ↔ 1
    2L(16042032-16048626)
    worm
    (Caenorhabditis elegans)
    Secernentea bcc-11 bcc-1 45.61(n)
    33.72(a)
      178008  NM_069666.5  NP_502067.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCP1606
    Essential RNA-binding G protein effector of mating...
    9(a)
    1 → many
    X(285558-289226) YJL080C


    ENSEMBL Gene Tree for BICC1 (if available)
    TreeFam Gene Tree for BICC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BICC1 gene
    HDLBP2  

    Find genes that share paralogs with BICC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BICC1 (see all 6192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0667604
    Renal dysplasia, cystic (CYSRD)4--see VAR_0667602 E G mis40--------
    rs1495089801,2
    Cuntested160815700(+) AGTTTA/CTTTTG 1 -- int10--------
    rs354642631,2
    C--54264889(+) CTTCC-/CTCTCTT 1 -- int12Minor allele frequency- CT:0.25NA CSA 4
    rs57853251,2
    C--54268204(+) CTAAA-/TATTATTA 1 -- int11Minor allele frequency- TAT:0.00CSA 2
    rs348772891,2
    C,F--54293032(+) AAAAA-/ACAAAC 1 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs354197921,2
    C,F--54295273(+) GAAATTG/-TGAGA 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1155731051,2
    C,F--54299337(+) GTTTTT/CTTTTT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs714670471,2
    C--54316485(+) CAAACATAT/-  
            
    ATGTA
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs570154731,2
    C--54316486(+) CAAAC-/AT    
       
    /ATAT
    GTACA
    1 -- int10--------
    rs30754001,2
    C--54316487(+) AACAT-/ATAT  
            
    GTACA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for BICC1 (60272900 - 60522900 bp, first 250kb of BICC1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BICC1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659339CNV Deletion23128226
    esv2676452CNV Deletion23128226
    esv2656976CNV Deletion23128226
    esv2674679CNV Deletion23128226
    esv2664920CNV Deletion23128226
    nsv6798CNV Insertion18451855
    esv268218CNV Insertion20981092
    esv32723CNV Loss17666407
    nsv825403CNV Loss20364138
    nsv508586CNV Loss20534489

    Human Gene Mutation Database (HGMD): BICC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BICC1
    DNA2.0 Custom Variant and Variant Library Synthesis for BICC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614295   
    OMIM disorders: 601331  
    UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694
  • Renal dysplasia, cystic (CYSRD) [MIM:601331]: An anomaly of the kidney characterized by numerous renal
    cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the
    normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains
    undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 2 diseases for BICC1:    
    About MalaCards
    renal dysplasia, cystic    renal dysplasia

    1 disease from the University of Copenhagen DISEASES database for BICC1:
    Polycystic kidney disease

    Find genes that share disorders with BICC1           About GenesLikeMe

    Genetic Association Database (GAD): BICC1
    Human Genome Epidemiology (HuGE) Navigator: BICC1 (5 documents)

    Export disorders for BICC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BICC1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with BICC1)
        Utopia: connect your pdf to the dynamic
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    1. Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. (PubMed id 21922595)1, 2 Kraus M.R.... Grapin-Botton A. (Hum. Mutat. 2012)
    2. Genome-wide association study of major recurrent depression in the U.K. population. (PubMed id 20516156)1, 4 Lewis C.M....McGuffin P. (Am J Psychiatry 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease. (PubMed id 15465627)1, 4 Riemenschneider M.... Kurz A. (Neurobiol. Aging 2004)
    7. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PubMed id 23396134)1 Verhoeven V.J....Hammond C.J. (Nat. Genet. 2013)
    8. Identification of a candidate gene for astigmatism. (PubMed id 23322567)1 Lopes M.C....Hammond C.J. (amp 2013)
    9. Effect of genetic variant in BICC1 on functional and structural brain changes in depression. (PubMed id 22910460)1 Bermingham R....Frodl T. (Neuropsychopharmacology 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80114 HGNC: 19351 AceView: BICC1 Ensembl:ENSG00000122870 euGenes: HUgn80114
    ECgene: BICC1 H-InvDB: BICC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BICC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BICC1 gene:
    Search GeneIP for patents involving BICC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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