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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BICC1 Gene

protein-coding GIFtS: 48
GCID: GC10P060272

bicaudal C homolog 1 (Drosophila)

Explore 5 diseases affiliated with
BICC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bicaudal C Homolog 1 (Drosophila)¹ ²
BICC²
CYSRD²
Bic-C³
Protein Bicaudal C Homolog 1²
Bic-C³

External Ids:	HGNC: 19351¹	Entrez Gene: 80114²	Ensembl: ENSG00000122870⁷	OMIM: 614295⁵	UniProtKB: Q9H694³

Export aliases for BICC1 gene to outside databases

Previous GC identifers: GC10P059348 GC10P059578 GC10P060445 GC10P059897 GC10P060223 GC10P054263

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BICC1:

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation

during embryonic development. Mouse studies identified the corresponding protein to be under strict control during

cell differentiation and to be a maternally provided gene product. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694

Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating

gene expression during embryonic development

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BICC1 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 Ik-3 HNF-1A Nkx3-1 v2 SRY HNF-1 FOXO1a Nkx3-1 v3
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for BICC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BICC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1 Ensembl cytogenetic band: 10q21.1 HGNC cytogenetic band: 10q21.3

BICC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BICC1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P060272: view genomic region (about GC identifiers)

Start:	60,272,900 bp from pter	End:	60,591,195 bp from pter
Size:	318,296 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694 (See protein sequence)

Recommended Name: Protein bicaudal C homolog 1

Size: 974 amino acids; 104844 Da

Sequence caution: Sequence=BAB15369.1; Type=Erroneous initiation;

Alternative splicing: 2 isoforms: Q9H694-1 Q9H694-2

Explore the universe of human proteins at neXtProt for BICC1: NX_Q9H694

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H694

BICC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073981.1

ENSEMBL proteins:

ENSP00000362993 ENSP00000263103

Human Recombinant Protein Products:

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	Uscn Proteins for BICC1

BICC1 Antibody Products:

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	Novus Biologicals BICC1 Antibody
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	Uscn Antibodies for BICC1
	Search ThermoFisher Antibodies for BICC1

Assay Products for BICC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for BICC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BICC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BICC1 for domains About GeneDecksing

5 InterPro domains/families:

IPR013761 SAM/pointed

IPR001660 SAM

IPR021129 SAM_type1

IPR004087 KH_dom

IPR004088 KH_dom_type_1

Graphical View of Domain Structure for InterPro Entry Q9H694

ProtoNet protein and cluster: Q9H694

UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694

Similarity: Belongs to the BicC family

Similarity: Contains 2 KH domains

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694

Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating

gene expression during embryonic development

miRNA Products:		OriGene 3'-UTR Clone: BICC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BICC1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate BICC1:
		hsa-miR-9 hsa-miR-133a hsa-miR-133b
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BICC1 (see all 7) OriGene shRNA RFP: BICC1 OriGene siRNA: BICC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BICC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BICC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BICC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BICC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: BICC1 (NM_001080512)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BICC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BICC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BICC1
		Search LifeMap BioReagents cell lines for BICC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BICC1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--

BICC1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Bicc1^tm1Bdc for BICC1
     11 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Bicc1):

behavior/neurological	cardiovascular system	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	homeostasis/metabolism	liver/biliary system	mortality/aging	renal/urinary system
reproductive system

BICC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BICC1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/6 Interacting proteins for BICC1 (Q9H694³ ENSP00000362993⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KHDRBS1	Q07666³, ENSP00000313829⁴	I2D: score=1 STRING: ENSP00000313829
QKI	Q96PU8³, ENSP00000354951⁴	I2D: score=1 STRING: ENSP00000354951
IPO13	O94829³	I2D: score=5
PAPLN	O95428³	I2D: score=5
KIAA1429	Q69YN4³	I2D: score=4

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	IDA	--

BICC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BICC1
Search CenterWatch for drugs/clinical trials and news about BICC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BICC1 gene:

NM_001080512.1

Unigene Cluster for BICC1:

Bicaudal C homolog 1 (Drosophila)

Hs.158745 [show with all ESTs]

Unigene Representative Sequence: NM_001080512

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373886(uc001jki.1) ENST00000476684 ENST00000263103(uc001jkj.1)

miRNA Products:		OriGene 3'-UTR Clone: BICC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BICC1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate BICC1:
		hsa-miR-9 hsa-miR-133a hsa-miR-133b
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BICC1 (see all 7) OriGene shRNA RFP: BICC1 OriGene siRNA: BICC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BICC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BICC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BICC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: BICC1 (NM_001080512)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BICC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BICC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BICC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BICC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BICC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BICC1

Additional cDNA sequence:

AK026129.1 AK225427.1 AK225429.1 AK307780.1 AY726586.1

2 DOTS entries:

DT.97806694 DT.97818140

9 AceView cDNA sequences:

BX282230 AA424272 BG751458 AI242865 BX538102 AK026129 BM972104 BG163356

AI375513

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BICC1 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10
SP1:
SP2:

ECgene alternative splicing isoforms for BICC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BICC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGCTGACT

About this image

BICC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BICC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BICC1

SOURCE GeneReport for Unigene cluster: Hs.158745

SABiosciences Custom PCR Arrays for BICC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BICC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BICC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BICC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BICC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BICC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BICC1 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bicc1^{1 , 5}	bicaudal C homolog 1 (Drosophila)^{1, 5}	86.21(n)¹ 93.12(a)¹		10 (36.75 cM)⁵ 83675¹ NM_031397.2¹ NP_113574.1¹ 70922832⁵
chicken (Gallus gallus)	Aves	BICC1¹	bicaudal C homolog 1 (Drosophila)	82.18(n) 89.6(a)		423604 NM_001199507.1 NP_001186436.1
lizard (Anolis carolinensis)	Reptilia	BICC1⁶	--	87(a)	1 ↔ 1	GL343251.1(1012453-1044758)
African clawed frog (Xenopus laevis)	Amphibia	Bic-C²	bicaudal-C	76.32(n)		AF224746.1
zebrafish (Danio rerio)	Actinopterygii	LOC568201¹	protein bicaudal C homolog 1-B-like	65.13(n) 67.87(a)		568201 XM_691516.4 XP_696608.4
fruit fly (Drosophila melanogaster)	Insecta	BicC¹	Bicaudal C	48.93(n) 42.91(a)		34946 NM_165144.1 NP_723948.1
worm (Caenorhabditis elegans)	Secernentea	bcc-1¹	Protein BCC-1	45.8(n) 32.62(a)		178008 NM_069666.4 NP_502067.2

ENSEMBL Gene Tree for BICC1 (if available)
TreeFam Gene Tree for BICC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BICC1 gene

ANKS6²

BICC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149508980^1,2	C,	unknown	54433210(+)	`AGTTTA/CTTTTG`	1	--	int¹		0	--	--	--	--
rs112334729^1,2		--	54261096(+)	`GGTCAG/ATATTC`	1	--	us2k¹		1		CSA	2
rs76558165^1,2	F,	--	54261379(+)	`CAGATG/ACTCTC`	1	--	us2k¹		1		WA	118
rs116287618^1,2	C,F,	--	54261904(+)	`CAGAGG/ATTACT`	1	--	us2k¹		1		WA	118
rs200032478^1,2	C	--	54262114(+)	`TTCAAA/GAAAAA`	1	--	us2k¹		0	--	--	--	--
rs11595201^1,2	H	--	54264219(+)	`TCTTCC/TTATGC`	1	--	int¹		0	--	--	--	--
rs34643160^1,2	C,F,	--	54264629(+)	`CTTACT/GTNNNN`	1	--	int¹		7		NA WA CSA	248
rs113104626^1,2		--	54265105(+)	`AGATCG/ATTTGG`	1	--	int¹		2		CSA WA	120
rs72818842^1,2	C,	--	54266118(+)	`TCCAGG/TGCCTA`	1	--	int¹		0	--	--	--	--
rs75442147^1,2		--	54268527(+)	`AAATAC/ATCTGC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for BICC1 (60272900 - 60522900 bp, first 250kb of BICC1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for BICC1
2 CNVs: 71026 6876
3 Indels: 60014 11038 71025
Human Gene Mutation Database (HGMD): BICC1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BICC1

DNA2.0 Custom Variant and Variant Library Synthesis for BICC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BICC1 for disorders About GeneDecksing

OMIM gene information: 614295 OMIM disorders: --

UniProtKB/Swiss-Prot: BICC1_HUMAN, Q9H694

Defects in BICC1 are a cause of susceptibility to renal dysplasia, cystic (CYSRD) [MIM:601331]. An anomaly of

the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma.

Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic,

dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts

5 diseases for BICC1: About MalaCards

polycystic kidney disease cystic kidney kidney disease alzheimer's disease

cholesterol

1 disease from the University of Copenhagen DISEASES database for BICC1:

Polycystic kidney disease

Genetic Association Database (GAD): BICC1
Human Genome Epidemiology (HuGE) Navigator: BICC1 (5 documents)

Export disorders for BICC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BICC1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with BICC1)

Utopia: connect your pdf to the dynamic
world of online information

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. (PubMed id 21922595)^{1, 2} Kraus M.R.... Grapin-Botton A. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease. (PubMed id 15465627)^{1, 4} Riemenschneider M.... Kurz A. (2004)
Genome-wide association study of major recurrent depression in the U.K. population. (PubMed id 20516156)¹ Lewis C.M....McGuffin P. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)² Olsen J.V....Mann M. (2006)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Identification and expression of the mammalian homologue of Bicaudal-C. (PubMed id 11231089)¹ Wessely O....De Robertis E.M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80114	HGNC: 19351	AceView: BICC1	Ensembl:ENSG00000122870	euGenes: HUgn80114
ECgene: BICC1	H-InvDB: BICC1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BICC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BICC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BICC1 gene:
Search GeneIP for patents involving BICC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for BICC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BICC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BICC1
	OriGene Protein Over-expression Lysate for BICC1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for BICC1		OriGene 3'-UTR Clone for BICC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BICC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BICC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
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	OriGene Custom Antibody Services for BICC1		OriGene Custom Protein Services for BICC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BICC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BICC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BICC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BICC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BICC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BICC1

	GenScript Custom Purified and Recombinant Proteins Services for BICC1		GenScript cDNA clones with any tag delivered in your preferred vector for BICC1
	GenScript Custom Assay Services for BICC1		GenScript Custom Superior Antibodies Services for BICC1
	GenScript Custom overexpressing Cell Line Services for BICC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in BICC1 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for BICC1 at Abcam
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Browse ProSpec Recombinant Proteins

BICC1 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BICC1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for BICC1
	Browse SwitchGear Promoter luciferase reporter plasmids for BICC1

Search ThermoFisher Antibodies for BICC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BICC1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes BICC1 gene at Home site.

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BICC1 Gene

bicaudal C homolog 1 (Drosophila)

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BICC1 Gene

bicaudal C homolog 1 (Drosophila)

Aliasesfor BICC1 gene

Summariesfor BICC1 gene

Genomic Viewsfor BICC1 gene

Proteinsfor BICC1 gene

Protein Domains /Familiesfor BICC1 gene

Functionfor BICC1 gene

Pathways & Interactionsfor BICC1 gene

Drugs & Compoundsfor BICC1 gene

Transcriptsfor BICC1 gene

Expression for BICC1 gene

Orthologsfor BICC1 gene

Paralogsfor BICC1 gene

Genomic Variantsfor BICC1 gene

Disorders / Diseasesfor BICC1 gene

Publicationsfor BICC1 gene

External Searches for BICC1 gene

Genome Databases showing BICC1 gene

Other Databases showing BICC1 gene

Specialized Databases showing BICC1 gene

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for BICC1 gene

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for BICC1 gene

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Families
for BICC1 gene

Function
for BICC1 gene

Pathways & Interactions
for BICC1 gene

Drugs & Compounds
for BICC1 gene

Transcripts
for BICC1 gene

Expression
for BICC1 gene

Orthologs
for BICC1 gene

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Genomic Variants
for BICC1 gene

Disorders / Diseases
for BICC1 gene

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for BICC1 gene

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for BICC1 gene

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for BICC1 gene