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Aliases for BICC1 Gene

Aliases for BICC1 Gene

  • BicC Family RNA Binding Protein 1 2 3
  • Bicaudal C Homolog 1 (Drosophila) 2
  • FGFR2-BICC1 Fusion Kinase Protein 3
  • Bicaudal C Homolog 1 3
  • CYSRD 3
  • Bic-C 4
  • BICC 3

External Ids for BICC1 Gene

Previous GeneCards Identifiers for BICC1 Gene

  • GC10P059348
  • GC10P059578
  • GC10P060445
  • GC10P059897
  • GC10P060223
  • GC10P054263
  • GC10P060272

Summaries for BICC1 Gene

Entrez Gene Summary for BICC1 Gene

  • This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

GeneCards Summary for BICC1 Gene

BICC1 (BicC Family RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with BICC1 include renal dysplasia, cystic and renal dysplasia. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HDLBP.

UniProtKB/Swiss-Prot for BICC1 Gene

  • Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BICC1 Gene

Genomics for BICC1 Gene

Regulatory Elements for BICC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BICC1 Gene

Chromosome:
10
Start:
58,512,916 bp from pter
End:
58,831,437 bp from pter
Size:
318,522 bases
Orientation:
Plus strand

Genomic View for BICC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BICC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICC1 Gene

Proteins for BICC1 Gene

  • Protein details for BICC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H694-BICC1_HUMAN
    Recommended name:
    Protein bicaudal C homolog 1
    Protein Accession:
    Q9H694

    Protein attributes for BICC1 Gene

    Size:
    974 amino acids
    Molecular mass:
    104844 Da
    Quaternary structure:
    • Interacts (via KH domains) with ANKS6 (via SAM domain) in an RNA-dependent manner (By similarity). Interacts with ANKS3 (By similarity).
    SequenceCaution:
    • Sequence=BAB15369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BICC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BICC1 Gene

Proteomics data for BICC1 Gene at MOPED

Post-translational modifications for BICC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BICC1 Gene

Domains & Families for BICC1 Gene

Gene Families for BICC1 Gene

Protein Domains for BICC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BICC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H694

UniProtKB/Swiss-Prot:

BICC1_HUMAN :
  • Contains 2 KH domains.
  • Belongs to the BicC family.
Domain:
  • Contains 2 KH domains.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the BicC family.
genes like me logo Genes that share domains with BICC1: view

Function for BICC1 Gene

Molecular function for BICC1 Gene

UniProtKB/Swiss-Prot Function:
Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.

Gene Ontology (GO) - Molecular Function for BICC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BICC1: view
genes like me logo Genes that share phenotypes with BICC1: view

Animal Models for BICC1 Gene

MGI Knock Outs for BICC1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BICC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BICC1 Gene

Localization for BICC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BICC1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BICC1 Gene COMPARTMENTS Subcellular localization image for BICC1 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for BICC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BICC1: view

Pathways & Interactions for BICC1 Gene

SuperPathways for BICC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 21922595
genes like me logo Genes that share ontologies with BICC1: view

No data available for Pathways by source and SIGNOR curated interactions for BICC1 Gene

Drugs & Compounds for BICC1 Gene

No Compound Related Data Available

Transcripts for BICC1 Gene

mRNA/cDNA for BICC1 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BICC1 Gene

Bicaudal C homolog 1 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BICC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BICC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for BICC1 Gene

GeneLoc Exon Structure for
BICC1
ECgene alternative splicing isoforms for
BICC1

Expression for BICC1 Gene

mRNA expression in normal human tissues for BICC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BICC1 Gene

This gene is overexpressed in Plasma (23.1), Pancreas (22.2), and Monocytes (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BICC1 Gene



SOURCE GeneReport for Unigene cluster for BICC1 Gene Hs.158745

genes like me logo Genes that share expression patterns with BICC1: view

Protein tissue co-expression partners for BICC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BICC1 Gene

Orthologs for BICC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BICC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BICC1 35
  • 92.53 (n)
  • 96.66 (a)
BICC1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BICC1 35
  • 94.32 (n)
  • 96.51 (a)
BICC1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bicc1 35
  • 86.17 (n)
  • 93.12 (a)
Bicc1 16
Bicc1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BICC1 35
  • 99.32 (n)
  • 99.18 (a)
BICC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bicc1 35
  • 85.72 (n)
  • 92.73 (a)
oppossum
(Monodelphis domestica)
Mammalia BICC1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BICC1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves BICC1 35
  • 82.2 (n)
  • 89.9 (a)
BICC1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BICC1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bicc1 35
  • 75.14 (n)
  • 84.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Bic-C 35
zebrafish
(Danio rerio)
Actinopterygii LOC568201 35
  • 64.66 (n)
  • 67.43 (a)
bicc1b 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BicC 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea bcc-1 35
  • 45.61 (n)
  • 33.72 (a)
bcc-1 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP160 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for BICC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BICC1 Gene

ENSEMBL:
Gene Tree for BICC1 (if available)
TreeFam:
Gene Tree for BICC1 (if available)

Paralogs for BICC1 Gene

Paralogs for BICC1 Gene

genes like me logo Genes that share paralogs with BICC1: view

Variants for BICC1 Gene

Sequence variations from dbSNP and Humsavar for BICC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs722520 -- 58,753,273(-) gggaa(C/T)cgctt intron-variant
rs768591 -- 58,775,805(-) AAAAT(G/T)ATCAC intron-variant
rs893369 -- 58,601,141(-) TATAT(A/T)AGTTT intron-variant
rs893370 -- 58,601,074(-) AAGTG(A/T)TCTTA intron-variant
rs919168 -- 58,555,384(+) ACTTG(G/T)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BICC1 Gene

Variant ID Type Subtype PubMed ID
esv28592 CNV Loss 19812545
nsv508586 CNV Loss 20534489
esv32825 CNV Loss 17666407
esv23021 CNV Loss 19812545
esv32723 CNV Loss 17666407
esv2656976 CNV Deletion 23128226
nsv831886 CNV Gain 17160897
nsv825403 CNV Loss 20364138
nsv6798 CNV Insertion 18451855
esv2676452 CNV Deletion 23128226
esv9199 CNV Gain 19470904
esv2659339 CNV Deletion 23128226
esv268218 CNV Insertion 20981092
esv2664920 CNV Deletion 23128226
esv2674679 CNV Deletion 23128226

Variation tolerance for BICC1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BICC1 Gene

HapMap Linkage Disequilibrium report
BICC1
Human Gene Mutation Database (HGMD)
BICC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICC1 Gene

Disorders for BICC1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BICC1 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
renal dysplasia, cystic
  • renal dysplasia, cystic, susceptibility to
renal dysplasia
  • renal cell dysplasia
refractive error
  • eye refraction disorder
- elite association
Search BICC1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BICC1_HUMAN
  • Renal dysplasia, cystic (CYSRD) [MIM:601331]: An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts. {ECO:0000269 PubMed:21922595}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for BICC1

Genetic Association Database (GAD)
BICC1
Human Genome Epidemiology (HuGE) Navigator
BICC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BICC1
genes like me logo Genes that share disorders with BICC1: view

No data available for Genatlas for BICC1 Gene

Publications for BICC1 Gene

  1. Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation. (PMID: 24501278) Lee H. … Nelson S.F. (Hum. Mol. Genet. 2014) 67
  2. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. (PMID: 24836286) Zhang B. … Zheng W. (Nat. Genet. 2014) 67
  3. Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. (PMID: 24789909) Mesner L.D. … Farber C.R. (J. Clin. Invest. 2014) 67
  4. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PMID: 23396134) Verhoeven V.J. … Hammond C.J. (Nat. Genet. 2013) 67
  5. Identification of a candidate gene for astigmatism. (PMID: 23322567) Lopes M.C. … Hammond C.J. (Invest. Ophthalmol. Vis. Sci. 2013) 67

Products for BICC1 Gene

Sources for BICC1 Gene

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