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BHMT2 Gene

protein-coding   GIFtS: 59
GCID: GC05P078366

Betaine--Homocysteine S-Methyltransferase 2

  See BHMT2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Betaine--Homocysteine S-Methyltransferase 21 2 3
SMM-Hcy Methyltransferase2 3
Betaine-Homocysteine Methyltransferase 22
S-Methylmethionine--Homocysteine S-Methyltransferase BHMT22
EC 2.1.1.103
EC 2.1.1.58

External Ids:    HGNC: 10481   Entrez Gene: 237432   Ensembl: ENSG000001328407   OMIM: 6059325   UniProtKB: Q9H2M33   

Export aliases for BHMT2 gene to outside databases

Previous GC identifers: GC05P077171 GC05P078602 GC05P078404 GC05P078449 GC05P078401 GC05P073571


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BHMT2 Gene:
Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the
methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA,
proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl
transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in
homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth
defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for BHMT2 Gene:
BHMT2 (betaine--homocysteine S-methyltransferase 2) is a protein-coding gene. Diseases associated with BHMT2 include vascular disease, and abdominal aortic aneurysm. GO annotations related to this gene include betaine-homocysteine S-methyltransferase activity and homocysteine S-methyltransferase activity. An important paralog of this gene is BHMT.

UniProtKB/Swiss-Prot: BHMT2_HUMAN, Q9H2M3
Function: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using
S-methylmethionine (SMM) as a methyl donor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the BHMT2 gene promoter:
         LHX3b/Lhx3b   Pax-5   POU3F1   FOXD1   MZF-1   POU2F1   POU2F1a   POU2F1b   LHX3a/Lhx3a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBHMT2 promoter sequence
   Search Chromatin IP Primers for BHMT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BHMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q13

BHMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BHMT2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P078366:  view genomic region     (about GC identifiers)

Start:
78,365,540 bp from pter      End:
78,385,897 bp from pter
Size:
20,358 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BHMT2_HUMAN, Q9H2M3 (See protein sequence)
Recommended Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2  
Size: 363 amino acids; 40354 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homotetramer (By similarity). May interact with PRNP
Sequence caution: Sequence=BAA90880.1; Type=Erroneous initiation;
Secondary accessions: B7Z516 Q9NXX7
Alternative splicing: 2 isoforms:  Q9H2M3-1   Q9H2M3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BHMT2: NX_Q9H2M3

Explore proteomics data for BHMT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for BHMT2 (Q9H2M3)
     LEKRGYVKAG  LIAEYFEHVEEA  RAIAEELAPERGFLP  ATRWDIQKYAREAYN 


    See BHMT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171476.1  NP_060084.2  

    ENSEMBL proteins: 
     ENSP00000255192   ENSP00000428640   ENSP00000430278   ENSP00000430155  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017226 Betaine-hCys_S-MeTrfase_BHMT
     IPR003726 S_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q9H2M3

    ProtoNet protein and cluster: Q9H2M3

    1 Blocks protein domain: IPB003726 Homocysteine S-methyltransferase

    UniProtKB/Swiss-Prot: BHMT2_HUMAN, Q9H2M3
    Similarity: Contains 1 Hcy-binding domain


    Find genes that share domains with BHMT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BHMT2_HUMAN, Q9H2M3
    Function: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using
    S-methylmethionine (SMM) as a methyl donor
    Catalytic activity: S-methyl-L-methionine + L-homocysteine = 2 L-methionine

         Enzyme Numbers (IUBMB): EC 2.1.1.101 EC 2.1.1.52

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0008898homocysteine S-methyltransferase activity IEA--
    GO:0047150betaine-homocysteine S-methyltransferase activity IEA--
         
    Find genes that share ontologies with BHMT2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BHMT2:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BHMT2
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    2 qRT-PCR Assays for microRNAs that regulate BHMT2:
    hsa-miR-34b hsa-miR-4309
    SwitchGear 3'UTR luciferase reporter plasmidBHMT2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with BHMT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BHMT2 About    
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    Methionine metabolism0.35
    methionine salvage0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for BHMT2
        Methionine metabolism

    1 BioSystems Pathway for BHMT2
        methionine salvage


    UniProtKB/Swiss-Prot: BHMT2_HUMAN, Q9H2M3
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine
    (BhmT route): step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BHMT2
    Interactions:

        Search GeneGlobe Interaction Network for BHMT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for BHMT2 (ENSP000002551924) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMGDHENSP000002551894STRING: ENSP00000255189
    MAT1AENSP000003612874STRING: ENSP00000361287
    MAT2AENSP000003031474STRING: ENSP00000303147
    MAT2BENSP000003254254STRING: ENSP00000325425
    SARDHENSP000003609384STRING: ENSP00000360938
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009086methionine biosynthetic process IEA--

    Find genes that share ontologies with BHMT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BHMT2

    8 HMDB Compounds for BHMT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Betaine(Carboxymethyl)trimethylammonium hydroxide inner salt (see all 31)107-43-7--
    Dimethylglycine(Dimethylamino)acetate (see all 9)1118-68-9--
    Homocysteine(+-)-homocysteine (see all 22)454-29-5--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for BHMT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3targetproduct of17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BHMT2 gene (2 alternative transcripts): 
    NM_001178005.1  NM_017614.4  

    Unigene Cluster for BHMT2:

    Betaine--homocysteine S-methyltransferase 2
    Hs.114172  [show with all ESTs]
    Unigene Representative Sequence: NM_017614
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255192(uc003kft.3 uc011cth.2) ENST00000518666 ENST00000521567
    ENST00000518758 ENST00000519743 ENST00000523472 ENST00000523046
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BHMT2:
    hsa-miR-34b hsa-miR-4309
    SwitchGear 3'UTR luciferase reporter plasmidBHMT2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF257473.1 AK000008.1 AK298298.1 AK315520.1 BC020665.1 

    11 DOTS entries:

    DT.100751691  DT.309982  DT.92424399  DT.70104496  DT.110423  DT.100650053  DT.100751692  DT.120889390 
    DT.400495  DT.92042863  DT.92424400 

    Selected AceView cDNA sequences (see all 97):

    AA873795 C21016 AI201379 N70916 AA298923 AA918097 AI000195 AW299252 
    NM_017614 AW024722 N76012 BC020665 AV720021 AV660450 AI768626 AI446623 
    CB159385 AI147545 AI913606 AV718642 AA745686 AF257473 AI264223 AA693837 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BHMT2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:              -                             -                                       
    SP2:                                            -                                       
    SP3:                                                                                    
    SP4:              -                                                                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for BHMT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BHMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCGGGTG
    BHMT2 Expression
    About this image


    BHMT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Kidney (Urinary System)
    BHMT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BHMT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.114172

    UniProtKB/Swiss-Prot: BHMT2_HUMAN, Q9H2M3
    Tissue specificity: Expressed in liver and kidney and at reduced levels in the brain, heart, and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BHMT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BHMT2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bhmt21 , 5 betaine-homocysteine methyltransferase 21, 5 84.53(n)1
    85.91(a)1
      13 (47.88 cM)5
    649181  NM_022884.21  NP_075022.21 
     936557205 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    67(a)
    1 → many
    Z(22291807-22310732)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    2(12969460-12974630)
    zebrafish
    (Danio rerio)
    Actinopterygii bhmt6
    betaine-homocysteine methyltransferase
    63(a)
    1 → many
    21(286522-291633) ENSDARG00000013430


    ENSEMBL Gene Tree for BHMT2 (if available)
    TreeFam Gene Tree for BHMT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BHMT2 gene
    BHMT2  
    1 SIMAP similar gene for BHMT2 using alignment to 3 protein entries:     BHMT2_HUMAN (see all proteins):
    BHMT

    Find genes that share paralogs with BHMT2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BHMT2
    PGOHUM00000249356


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BHMT2 (see all 429)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29098551,2
    C,A--73580034(+) CTGGGG/AAAAAA 2 -- int1 trp33Minor allele frequency- A:0.17NA 6
    rs4858511,2
    C,F,H--78367464(+) CAACAC/GACACT 2 -- int19Minor allele frequency- G:0.49NA WA CSA EA 370
    rs68899981,2
    C,F,A,H--78367668(+) AAAAAT/ACTAAA 2 -- int1 trp37Minor allele frequency- A:0.36NA WA CSA 14
    rs601140731,2
    C--78367668(+) AAAAA-/A/TCTAAA 2 -- int10--------
    rs742916081,2
    C,F--78367689(+) TACTGG/CTATAG 2 -- int11Minor allele frequency- C:0.12EA 120
    rs1853382201,2
    --78367777(+) TATTTC/TGCTAA 2 -- int10--------
    rs623779481,2
    C,F--78367779(+) TTTTGC/GTAATG 2 -- int18Minor allele frequency- G:0.20NA WA CSA EA 368
    rs1901458051,2
    --78367897(+) CCACAC/GTGGAC 2 -- int10--------
    rs1444541771,2
    C--78368016(+) ACCCTA/GGAGGT 2 -- int10--------
    rs1480024871,2
    --78368017(+) CCCTGC/GAGGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for BHMT2 (78365540 - 78385897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BHMT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462216CNV Loss19166990
    nsv519156CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BHMT2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605932    OMIM disorders: --

    3 diseases for BHMT2:    
    About MalaCards
    vascular disease    abdominal aortic aneurysm    spina bifida

    2 diseases from the University of Copenhagen DISEASES database for BHMT2:
    Cleft lip     Cleft palate

    Find genes that share disorders with BHMT2           About GenesLikeMe

    Genetic Association Database (GAD): BHMT2
    Human Genome Epidemiology (HuGE) Navigator: BHMT2 (20 documents)

    Export disorders for BHMT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BHMT2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with BHMT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine- homocysteine methyltransferase. (PubMed id 18230605)1, 2, 3, 9 Szegedi S.S.... Garrow T.A. (J. Biol. Chem. 2008)
    2. Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. (PubMed id 11087663)1, 2, 3, 9 Chadwick L.H.... Nadeau J.H. (Genomics 2000)
    3. Associations of folate and choline metabolism gene polymorphisms with orofacial clefts. (PubMed id 19737740)1, 4 Mostowska A....Jagodzinski P.P. (J. Med. Genet. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts. (PubMed id 20662904)1, 4 Mostowska A....Jagodzinski P.P. (Eur. J. Oral Sci. 2010)
    6. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. (PubMed id 20458436)1, 4 Giusti B....Abbate R. (Thromb. Haemost. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    9. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    10. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PubMed id 19048631)1, 4 Boyles A.L....Lie R.T. (Genet. Epidemiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23743 HGNC: 1048 AceView: BHMT2 Ensembl:ENSG00000132840 euGenes: HUgn23743
    ECgene: BHMT2 H-InvDB: BHMT2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BHMT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BHMT2 gene:
    Search GeneIP for patents involving BHMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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