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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BHLHE41 Gene

protein-coding   GIFtS: 55
GCID: GC12M026272

basic helix-loop-helix family, member e41

(Previous names: basic helix-loop-helix domain containing, class B, 3 )
(Previous symbol: BHLHB3)
 Explore 14 diseases affiliated with
BHLHE41 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BHLHE41    

Aliases
for BHLHE41 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Basic Helix-Loop-Helix Family, Member E411 2     Differentially Expressed In Chondrocytes Protein 22 3
BHLHB31 2 3 5     Enhancer-Of-Split And Hairy-Related Protein 12 3
DEC21 2 3 5     HDEC21
SHARP11 2 3 5     Class E Basic Helix-Loop-Helix Protein 412
Basic Helix-Loop-Helix Domain Containing, Class B, 31 2     Differentially Expressed In Chondrocytes 22
SHARP-11 3     BHLHb31
BHLHe411     Class B Basic Helix-Loop-Helix Protein 33

External Ids:    HGNC: 166171   Entrez Gene: 793652   Ensembl: ENSG000001230957   OMIM: 6062005   UniProtKB: Q9C0J93   

Export aliases for BHLHE41 gene to outside databases

Previous GC identifers: GC12M026165 GC12M026043


Summaries
for BHLHE41 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BHLHE41:
This gene encodes a transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic
helix-loop-helix factors. The encoded protein functions as a transcriptional repressor and as a regulator of molecular
clock. Defects in this gene are associated with the short sleep phenotype. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: BHE41_HUMAN, Q9C0J9
Function: May be a transcriptional repressor that represses both basal and activated transcription

Gene Wiki entry for BHLHE41 (BHLHB3)


Genomic Views
for BHLHE41 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BHLHE41 gene promoter:
         TBP   GCNF   Lmo2   MyoD   C/EBPalpha   CHOP-10   PPAR-alpha   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BHLHE41 promoter sequence
   Search SABiosciences Chromatin IP Primers for BHLHE41

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BHLHE41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12.1

BHLHE41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BHLHE41 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M026272:  view genomic region     (about GC identifiers)

Start:
 26,272,959 bp from pter      End:
 26,278,060 bp from pter
Size:
 5,102 bases      Orientation:
 minus strand

Proteins
for BHLHE41 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BHE41_HUMAN, Q9C0J9 (See protein sequence)
Recommended Name: Class E basic helix-loop-helix protein 41  
Size: 482 amino acids; 50498 Da
Subunit: Homodimerize
Subcellular location: Nucleus (By similarity)
Secondary accessions: A2I2N8

Explore the universe of human proteins at neXtProt for BHLHE41: NX_Q9C0J9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0J9

    • BHLHE41 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_110389.1  
    ENSEMBL proteins: 
     ENSP00000242728  
    Reactome Protein details: Q9C0J9
    Human Recombinant Protein Products: 
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    Novus Biologicals BHLHE41 Protein
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    Uscn Proteins for BHLHE41

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    BHLHE41 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BHLHE41

    Protein Domains /
    Families
    for BHLHE41 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BHLHE41 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018352 Orange_subgr
     IPR003650 Orange
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0J9

    ProtoNet protein and cluster: Q9C0J9

    2 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: BHE41_HUMAN, Q9C0J9
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    Function
    for BHLHE41 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BHE41_HUMAN, Q9C0J9
    Function: May be a transcriptional repressor that represses both basal and activated transcription

    miRNA
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    hsa-miR-100* hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-4305 hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BHLHE41 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BHLHE41 (see all 4)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS--


    BHLHE41 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for BHLHE41: Bhlhe41tm1.1Cdon Bhlhe41tm1Mjro
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bhlhe41):
     behavior/neurological  cellular  hematopoietic system  immune system 

    BHLHE41 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BHLHE41 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Circadian rhythm - mammal
    		Circadian rhythm - mammal1.00
    		BMAL1:CLOCK/NPAS2 Activates Circadian Expression0.23
    		Circadian Clock0.41
    2Expression of DEC2 (BHLHE41, BHLHB3)
    		Expression of DEC2 (BHLHE41, BHLHB3)1.00
    3HIF-1-alpha transcription factor network
    		HIF-1-alpha transcription factor network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for BHLHE41 
        HIF-1-alpha transcription factor network

    3        Reactome Pathways for BHLHE41
        Circadian Clock
    Expression of DEC2 (BHLHE41, BHLHB3)
    BMAL1:CLOCK/NPAS2 Activates Circadian Expression


    1         Kegg Pathway  (Kegg details for BHLHE41):
        Circadian rhythm - mammal


    BHLHE41 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BHLHE41

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for BHLHE41 (Q9C0J93 ENSP000002427284) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=2 STRING: ENSP00000250003
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    BHLHE40O145033, ENSP000002564954I2D: score=1 STRING: ENSP00000256495
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    CEBPBP176763, ENSP000003054224I2D: score=2 STRING: ENSP00000305422
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15193144
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007623circadian rhythm ----
    GO:0008283cell proliferation NAS11162494


    BHLHE41 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BHLHE41 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BHLHE41 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BHLHE41
    1 Novoseek chemical compound relationship for BHLHE41 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 34.5 8 18233956 (4), 17342330 (1)

    Search CenterWatch for drugs/clinical trials and news about BHLHE41 / BHE41 

    Transcripts
    for BHLHE41 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BHLHE41 gene: 
    NM_030762.2  

    Unigene Cluster for BHLHE41:

    Basic helix-loop-helix family, member e41
    Hs.177841  [show with all ESTs]
    Unigene Representative Sequence: NM_030762
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242728(uc001rhb.3) ENST00000394326 ENST00000541271

    miRNA
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    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate BHLHE41 (see all 114):
    hsa-miR-100* hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-4305 hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BHLHE41 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BHLHE41 (see all 4)
    OriGene shRNA RFP: BHLHE41
    OriGene siRNA: BHLHE41
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BHLHE41
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BHLHE41
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    Additional cDNA sequence: 

    AB044088.1 AJ270695.1 AK094422.1 AK303677.1 AK311258.1 AY665466.1 AY665467.1 BC025968.1 

    9 DOTS entries:

    DT.99952715  DT.75158325  DT.453922  DT.214099  DT.95164151  DT.95164148  DT.121206005  DT.95164150 
    DT.91996871 

    24/169 AceView cDNA sequences (see all 169):

    BQ774398 AA594434 AW627456 BC025968 BG929136 N50868 AI978761 BM978873 
    CR615693 N45639 BM670254 BQ955258 AI028096 AA828321 AA296750 BM994195 
    BQ002547 AW615360 AI022846 W37595 AB044088 AI222179 AA709437 AK094422 

    GeneLoc Exon Structure


    Expression
    for BHLHE41 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BHLHE41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTATTTTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BHLHE41 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BHLHE41 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BHLHE41

    SOURCE GeneReport for Unigene cluster: Hs.177841

    UniProtKB/Swiss-Prot: BHE41_HUMAN, Q9C0J9
    Tissue specificity: Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly
    expressed in placenta, lung, liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including BHLHE41: 
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BHLHE41

    Orthologs
    for BHLHE41 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for BHLHE41 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Bhlhe411 , 5 basic helix-loop-helix family, member e411, 5 85.29(n)1
    85.78(a)1    		   6 (77.70 cM)5
    793621  NM_024469.11  NP_077789.11 
     1458582435 
    lizard
    (Anolis carolinensis)    		 Reptilia BHLHE416
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343349.1(1157889-1165452)
    zebrafish
    (Danio rerio)    		 Actinopterygii bhlhe411 basic helix-loop-helix family, member e41 64.69(n)
    67.61(a)    		   563771  NM_001039107.1  NP_001034196.1 


    ENSEMBL Gene Tree for BHLHE41 (if available)
    TreeFam Gene Tree for BHLHE41 (if available) 

    Paralogs
    for BHLHE41 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BHLHE41 gene
    BHLHE402  
    3 SIMAP similar genes for BHLHE41 using alignment to 2 protein entries:     BHE41_HUMAN (see all proteins):
    BHLHB3    BHLHB2    BHLHE40

    BHLHE41 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BHLHE41
    PGOHUM00000262871


    Genomic Variants
    for BHLHE41 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: BHE41_HUMAN, Q9C0J9
    Polymorphism: Genetic variations in BHLHE41 are associated with the short sleep phenotype [MIM:612975]. Individuals
    with this trait require less sleep in any 24-hour period than is typical for their age group


    10/91 NCBI SNPs in BHLHE41 are shown (see all 91)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs762689171,2
    		F,--26043653(+) TTTATC/TGTCAC 1 -- ut311Minor allele frequency- T:0.04NA 120
    rs1170863551,2
    		C,F,--26044194(+) AGATAG/AGNNNN 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs747676971,2
    		--26044217(+) TCATTC/TTATAT 1 -- ut310--------
    rs49639561,2
    		C,H,--26044527(+) TGAGTC/TCATTA 1 -- ut31 ese33Minor allele frequency- T:0.01NS NA 182
    rs763062141,2
    		C,F,--26044746(+) TGCCTT/CTNNNN 1 -- ut311Minor allele frequency- C:0.05NA 120
    rs777573391,2
    		F,--26046189(+) GTATTC/TAAGTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs756772801,2
    		C,--26046568(+) GGCGGG/TTAAAG 2 T P mis10--------
    rs79722251,2
    		C,F,H,--26046715(+) CAGCAA/GTTTAA 1 -- int19Minor allele frequency- G:0.11NS NA WA 1014
    rs1125808931,2
    		--26047272(+) GTACCC/AAGCAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs14800371,2
    		C,F,A,H,--26047853(-) TGTGTG/ATGTGC 1 -- ut5117Minor allele frequency- A:0.03NA EA MN NS 2126

    HapMap Linkage Disequilibrium report for BHLHE41 (26272959 - 26278060 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BHLHE41: --
    Human Gene Mutation Database (HGMD): BHLHE41

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    Disorders / Diseases
    for BHLHE41 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BHLHE41 for disorders           About GeneDecksing

    OMIM gene information: 606200   
    OMIM disorders: 612975  
    14 diseases for BHLHE41:    About MalaCards
    short sleeper    bipolar i disorder    schizoaffective disorder    mood disorder
    bipolar disorder    endometrial carcinoma    lung adenocarcinoma    lung cancer
    adenocarcinoma    breast cancer    carcinoma    hypoxia
    schizophrenia    melanoma

    2 Novoseek disease relationships for BHLHE41 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 7.86 2 17342330 (1), 20236182 (1)
    carcinoma 1.98 1 12624110 (1)

    Human Genome Epidemiology (HuGE) Navigator: BHLHE41 (0 documents)

    Export disorders for BHLHE41 gene to outside databases

    Publications
    for BHLHE41 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BHLHE41 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with BHLHE41)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. (PubMed id 11162494)1, 2, 3, 9 Fujimoto K.... Kato Y. (2001)
    2. The transcriptional repressor DEC2 regulates sleep le ngth in mammals. (PubMed id 19679812)1, 2 He Y....Fu Y.H. (2009)
    3. Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. (PubMed id 18557763)1, 3 Stevens J.D....Skinner M.K. (2008)
    4. The basic helix-loop-helix protein, SHARP-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism. (PubMed id 11278948)1, 2 Garriga-Canut M.... Buckley N.J. (2001)
    5. DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. (PubMed id 12624110)1, 9 Li Y....Yan B. (2003)
    6. Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. (PubMed id 12354771)1, 9 Miyazaki K....Kato Y. (2002)
    7. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. (PubMed id 18345027)1, 9 Nakamura H....Nishiyama M. (2008)
    8. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. (PubMed id 15560782)1, 9 Sato F....Kato Y. (2004)
    9. SHARP1 suppresses breast cancer metastasis by promotin g degradation of hypoxia-inducible factors. (PubMed id 22801492)1 Montagner M....Piccolo S. (2012)
    10. BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells. (PubMed id 22572381)1 Wu Y....Kijima H. (2012)

    External Searches for BHLHE41 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Disorders
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    Genome Databases showing BHLHE41 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79365 HGNC: 16617 AceView: BHLHB3 Ensembl:ENSG00000123095 euGenes: HUgn79365
    ECgene: BHLHE41 Kegg: 79365 H-InvDB: BHLHE41

    Other Databases showing BHLHE41 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BHLHE41 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BHLHE41 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BHLHE41 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BHLHE41 gene:
    Search GeneIP for patents involving BHLHE41

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