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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BHLHE40 Gene

protein-coding   GIFtS: 56
GCID: GC03P004997

basic helix-loop-helix family, member e40

(Previous names: basic helix-loop-helix domain containing, class B, 2 )
(Previous symbols: STRA13, BHLHB2)
 Explore 18 diseases affiliated with
BHLHE40 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BHLHE40    

Aliases
for BHLHE40 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Basic Helix-Loop-Helix Family, Member E401 2     Stimulated By Retinoic Acid Gene 13 Protein2 3
DEC11 2 3 5     SHARP-22 3
STRA131 2 3 5     HLHB22 5
BHLHB21 2 3     Stra142
Basic Helix-Loop-Helix Domain Containing, Class B, 21 2     Class E Basic Helix-Loop-Helix Protein 402
BHLHe401     Differentially Expressed In Chondrocytes 12
Class B Basic Helix-Loop-Helix Protein 22 3     Differentiated Embryo Chondrocyte Expressed Gene 12
Differentially Expressed In Chondrocytes Protein 12 3     SHARP23
Enhancer-Of-Split And Hairy-Related Protein 22 3     BHLHb21

External Ids:    HGNC: 10461   Entrez Gene: 85532   Ensembl: ENSG000001341077   OMIM: 6042565   UniProtKB: O145033   

Export aliases for BHLHE40 gene to outside databases


Summaries
for BHLHE40 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BHLHE40:
This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is
responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell
differentiation. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: BHE40_HUMAN, O14503
Function: May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway

Gene Wiki entry for BHLHE40 (BHLHB2)


Genomic Views
for BHLHE40 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BHLHE40 gene promoter:
         Max1   p53   AP-1   SREBP-1c   p300   ATF-2   SREBP-1b   SREBP-1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BHLHE40 promoter sequence
   Search SABiosciences Chromatin IP Primers for BHLHE40

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BHLHE40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26   Ensembl cytogenetic band:  3p26.1   HGNC cytogenetic band: 3p26

BHLHE40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BHLHE40 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P004997:  view genomic region     (about GC identifiers)

Start:
 5,020,801 bp from pter      End:
 5,027,008 bp from pter
Size:
 6,208 bases      Orientation:
 plus strand

Proteins
for BHLHE40 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BHE40_HUMAN, O14503 (See protein sequence)
Recommended Name: Class E basic helix-loop-helix protein 40  
Size: 412 amino acids; 45510 Da
Subunit: Able to homodimerize or heterodimerize with TCF3/E47. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9
Subcellular location: Nucleus
Secondary accessions: Q96TD3

Explore the universe of human proteins at neXtProt for BHLHE40: NX_O14503

Post-translational modifications:

  • Ubiquitinated; which may lead to proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14503

    • BHLHE40 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003661.1  
    ENSEMBL proteins: 
     ENSP00000256495  
    Reactome Protein details: O14503
    Human Recombinant Protein Products: 
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    Uscn Proteins for BHLHE40

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9240428
    GO:0005730nucleolus IDA--
    GO:0005794Golgi apparatus IDA--


    BHLHE40 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BHLHE40

    Protein Domains /
    Families
    for BHLHE40 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BHLHE40 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018352 Orange_subgr
     IPR003650 Orange
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry O14503

    ProtoNet protein and cluster: O14503

    2 Blocks protein families:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB003650 Orange


    UniProtKB/Swiss-Prot: BHE40_HUMAN, O14503
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 Orange domain


    Function
    for BHLHE40 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BHE40_HUMAN, O14503
    Function: May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IDA12397359
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA15193144
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription IDA18411297
    GO:0003677DNA binding ----


    BHLHE40 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for BHLHE40: Bhlhe40tm1Tan Bhlhe40tm1.1Rhli
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Bhlhe40):
     behavior/neurological  cellular  hematopoietic system  immune system  nervous system 
     no phenotypic analysis  renal/urinary system 

    BHLHE40 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BHLHE40 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Circadian rhythm - mammal
    		Circadian rhythm - mammal1.00
    		BMAL1:CLOCK/NPAS2 Activates Circadian Expression0.23
    		Circadian Clock0.41
    2Expression of DEC1 (BHLHE40, BHLHB2)
    		Expression of DEC1 (BHLHE40, BHLHB2)1.00
    3SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    4Heart Development
    		Heart Development1.00
    5HIF-1-alpha transcription factor network
    		HIF-1-alpha transcription factor network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5 BioSystems Pathways for BHLHE40 
        SIDS Susceptibility Pathways
    Heart Development
    HIF-1-alpha transcription factor network
    Circadian rhythm pathway
    HIF-2-alpha transcription factor network

    3        Reactome Pathways for BHLHE40
        Circadian Clock
    BMAL1:CLOCK/NPAS2 Activates Circadian Expression
    Expression of DEC1 (BHLHE40, BHLHB2)


    1         Kegg Pathway  (Kegg details for BHLHE40):
        Circadian rhythm - mammal


    BHLHE40 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BHLHE40

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for BHLHE40 (O145031, 2, 3 ENSP000002564954) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-4544983 MINT-4544966 MINT-4545030 MINT-4654062 MINT-4545046 I2D: score=1 STRING: ENSP00000269305
    UBE2IP632791, 3, ENSP000003248974EBI-711810,EBI-80168 I2D: score=2 STRING: ENSP00000324897
    MDM2Q009872, 3, ENSP000004172814MINT-4544999 I2D: score=1 STRING: ENSP00000417281
    BRD7Q9NPI12, 3MINT-63052 I2D: score=5 
    CHD3Q128732, 3MINT-63054 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15193144
    GO:0006355regulation of transcription, DNA-dependent NAS9240428
    GO:0006366transcription from RNA polymerase II promoter IDA12397359
    GO:0007623circadian rhythm ----
    GO:0009416response to light stimulus ----


    BHLHE40 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BHLHE40 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BHLHE40 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BHLHE40

    1 HMDB Compound for BHLHE40    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    3 Novoseek chemical compound relationships for BHLHE40 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 38.7 2 12594185 (2)
    vegf 18.6 3 12754744 (1), 18233956 (1), 17342330 (1)
    forskolin 18.4 3 11432722 (2), 12594185 (1)

    Search CenterWatch for drugs/clinical trials and news about BHLHE40 / BHE40 

    Transcripts
    for BHLHE40 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BHLHE40 gene: 
    NM_003670.2  

    Unigene Cluster for BHLHE40:

    Basic helix-loop-helix family, member e40
    Hs.171825  [show with all ESTs]
    Unigene Representative Sequence: NM_003670
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256495(uc003bqf.3 uc011asw.2) ENST00000467610 ENST00000460806


    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate BHLHE40 (see all 48):
    hsa-miR-100* hsa-miR-376b hsa-miR-300 hsa-miR-330-5p hsa-miR-548k hsa-miR-200a hsa-miR-374a hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: BHLHE40 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB004066.1 AK312509.1 BC068292.1 BC082238.1 CR456921.1 

    18 DOTS entries:

    DT.65285476  DT.100890828  DT.95329147  DT.120923168  DT.100890878  DT.92449152  DT.100799601  DT.100032845 
    DT.100890865  DT.319007  DT.319012  DT.95354614  DT.100890834  DT.97858669  DT.100890825  DT.100890848 
    DT.120923112  DT.95297453 

    24/360 AceView cDNA sequences (see all 360):

    BQ102290 AI865310 AW338921 AA927362 AL703091 CD679458 AI081906 AI384049 
    CA393643 CR610415 AI811452 BM477781 CA393585 BM703770 CK820242 AI373718 
    AL047484 CK820241 BQ086184 AA026120 BM263208 AI288346 AI093173 BQ879761 

    GeneLoc Exon Structure


    Expression
    for BHLHE40 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BHLHE40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAGGTAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BHLHE40 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See BHLHE40 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BHLHE40

    SOURCE GeneReport for Unigene cluster: Hs.171825

    UniProtKB/Swiss-Prot: BHE40_HUMAN, O14503
    Tissue specificity: Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver,
    muscle and stomach

        SABiosciences Expression via Pathway-Focused PCR Arrays including BHLHE40: 
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              Circadian Rhythms in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
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    Orthologs
    for BHLHE40 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for BHLHE40 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BHLHE401 basic helix-loop-helix family, member e40 72.33(n)
    73.75(a)    		   416108  XM_414439.2  XP_414439.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BHLHE406
    		 --
    		 71(a)
    		 1 ↔ 1
    		 2(173035316-173041943)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufm54h072 wufm54h07 75.86(n)   335746  CD284443.1 


    ENSEMBL Gene Tree for BHLHE40 (if available)
    TreeFam Gene Tree for BHLHE40 (if available) 

    Paralogs
    for BHLHE40 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BHLHE40 gene
    BHLHE412  
    2 SIMAP similar genes for BHLHE40 using alignment to 1 protein entry:     BHE40_HUMAN:
    BHLHB2    BHLHE41

    BHLHE40 for paralogs           About GeneDecksing



    Genomic Variants
    for BHLHE40 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in BHLHE40 are shown (see all 186)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1161296661,2
    		F,--5019137(+) TTCGCC/GCAGTC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs731060611,2
    		C,--5019140(+) GCCCAG/ATCTCG 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1482882671,2
    		--5019182(+) CACAGC/GCAGGT 1 -- us2k10--------
    rs38066761,2
    		C,F,--5019442(-) CACCTC/TCCCCG 1 -- us2k11Minor allele frequency- T:0.05EA 120
    rs1932174751,2
    		--5019453(+) GGTGGC/GGCCCT 1 -- us2k10--------
    rs1467290131,2
    		C,--5019544(+) CTTCT-/CCCCCG 1 -- us2k10--------
    rs1855828971,2
    		--5019546(+) TCTCCC/GCCGCT 1 -- us2k10--------
    rs8678931,2
    		C,F,A,--5019579(+) ACAATG/TAAATT 1 -- us2k19Minor allele frequency- T:0.24NA WA CSA EA 370
    rs1404999611,2
    		--5019607(+) CAACAA/CAAGTT 1 -- us2k10--------
    rs22494361,2
    		C,H,--5019764(+) CCTAGC/TGCAGA 1 -- us2k111Minor allele frequency- T:0.13NA WA CSA EA 373

    HapMap Linkage Disequilibrium report for BHLHE40 (5020801 - 5027008 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BHLHE40: --

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    Disorders / Diseases
    for BHLHE40 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BHLHE40 for disorders           About GeneDecksing

    OMIM gene information: 604256    OMIM disorders: --

    18 diseases for BHLHE40:    About MalaCards
    atrial fibrillation    pancreatic ductal adenocarcinoma    mood disorder    burkitt's lymphoma
    bipolar disorder    colon carcinoma    endometrial carcinoma    breast cancer
    hepatocellular carcinoma    carcinoma    pancreatitis    gastric cancer
    pancreatic cancer    lung cancer    adenocarcinoma    hypoxia
    hepatitis    neuronitis

    7 Novoseek disease relationships for BHLHE40 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 26.8 2 12624110 (1), 12119049 (1)
    tumors 8.58 5 16462771 (1), 19624270 (1), 17376295 (1), 20236182 (1)
    carcinoma 6.79 5 15328513 (2), 12624110 (1), 11432722 (1)
    breast cancer 0 5 15328513 (2), 20236182 (2)
    colorectal cancer 0 1 17611704 (1)
    melanoma 0 1 11432722 (1)
    cancer 0 3 18345027 (1), 19624270 (1), 15221940 (1)

    Human Genome Epidemiology (HuGE) Navigator: BHLHE40 (0 documents)

    Export disorders for BHLHE40 gene to outside databases

    Publications
    for BHLHE40 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BHLHE40 gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with BHLHE40)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. (PubMed id 9240428)1, 2, 3, 9 Shen M.... Kato Y. (1997)
    2. Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2. (PubMed id 11226878)1, 2, 9 Teramoto M.... Kato Y. (2001)
    3. Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. (PubMed id 18557763)1, 3 Stevens J.D....Skinner M.K. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. (PubMed id 11278694)1, 2 Ivanova A.V.... Lerman M.I. (2001)
    6. Assignment1 of the human Stra13 gene (STRA13) to chro mosome 3p26 by in situ hybridization. (PubMed id 10449910)1, 3 Antonevich T. and Taneja R. (1999)
    7. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. (PubMed id 18025081)1, 9 Qian Y....Chen X. (2008)
    8. The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. (PubMed id 16462771)1, 9 Li Y....Yan B. (2006)
    9. DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. (PubMed id 12624110)1, 9 Li Y....Yan B. (2003)
    10. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. (PubMed id 15560782)1, 9 Sato F....Kato Y. (2004)

    External Searches for BHLHE40 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing BHLHE40 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8553 HGNC: 1046 AceView: BHLHB2 Ensembl:ENSG00000134107 euGenes: HUgn8553
    ECgene: BHLHE40 Kegg: 8553 H-InvDB: BHLHE40

    Other Databases showing BHLHE40 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BHLHE40 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BHLHE40 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BHLHE40 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BHLHE40 gene:
    Search GeneIP for patents involving BHLHE40

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