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BHLHE22 Gene

protein-coding   GIFtS: 48
GCID: GC08P065492

Basic Helix-Loop-Helix Family, Member E22

(Previous names: trinucleotide repeat containing 20, basic helix-loop-helix...)
(Previous symbols: TNRC20, BHLHB5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Basic Helix-Loop-Helix Family, Member E221 2     Beta32
BHLHB51 2 3 5     CAGL852
TNRC201 2 3     Class E Basic Helix-Loop-Helix Protein 222
Basic Helix-Loop-Helix Domain Containing, Class B, 51 2     bHLHb53
Trinucleotide Repeat Containing 201 2     bHLHe223
Class B Basic Helix-Loop-Helix Protein 52 3     BETA35
Trinucleotide Repeat-Containing Gene 20 Protein2 3     

External Ids:    HGNC: 119631   Entrez Gene: 273192   Ensembl: ENSG000001808287   OMIM: 6134835   UniProtKB: Q8NFJ83   

Export aliases for BHLHE22 gene to outside databases

Previous GC identifers: GC08P065656 GC08P060983


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BHLHE22 Gene:
BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate
determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA
sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002
(PubMed 12213201)).(supplied by OMIM, Jul 2010)

GeneCards Summary for BHLHE22 Gene:
BHLHE22 (basic helix-loop-helix family, member e22) is a protein-coding gene. Diseases associated with BHLHE22 include labyrinthitis, and retinitis. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and protein homodimerization activity. An important paralog of this gene is OLIG3.

UniProtKB/Swiss-Prot: BHE22_HUMAN, Q8NFJ8
Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong
repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic
helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the BHLHE22 gene promoter:
         GR   AP-1   GR-beta   ATF-2   Nkx2-5   LCR-F1   SEF-1 (1)   STAT3   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBHLHE22 promoter sequence
   Search Chromatin IP Primers for BHLHE22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BHLHE22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q12.3   HGNC cytogenetic band: 8q12.1

BHLHE22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BHLHE22 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P065492:  view genomic region     (about GC identifiers)

Start:
65,492,795 bp from pter      End:
65,496,191 bp from pter
Size:
3,397 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BHE22_HUMAN, Q8NFJ8 (See protein sequence)
Recommended Name: Class E basic helix-loop-helix protein 22  
Size: 381 amino acids; 36997 Da

Explore the universe of human proteins at neXtProt for BHLHE22: NX_Q8NFJ8

Explore proteomics data for BHLHE22 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BHLHE22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689627.1  
    ENSEMBL proteins: 
     ENSP00000318799  

    BHLHE22 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFJ8

    ProtoNet protein and cluster: Q8NFJ8

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: BHE22_HUMAN, Q8NFJ8
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    BHLHE22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BHE22_HUMAN, Q8NFJ8
    Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong
    repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic
    helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
    GO:0046983protein dimerization activity ----
         
    BHLHE22 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BHLHE22:
     Lamellipodia and high actin ra 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bhlhe22):
     behavior/neurological  cellular  growth/size/body  integument  nervous system 
     vision/eye 

    BHLHE22 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bhlhe22tm1Meg for BHLHE22

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BHLHE22
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    miRNA
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    miRTarBase miRNAs that target BHLHE22:
    hsa-mir-335-5p (MIRT017669)

    Block miRNA regulation of human, mouse, rat BHLHE22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BHLHE22 (see all 38):
    hsa-miR-513a-5p hsa-miR-3653 hsa-miR-624 hsa-miR-192 hsa-miR-3658 hsa-miR-149 hsa-miR-29a* hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidBHLHE22 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BHLHE22

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BHLHE22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BHE22_HUMAN, Q8NFJ8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    BHLHE22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BHLHE22
    Interactions:

        Search GeneGlobe Interaction Network for BHLHE22

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for BHLHE22 (ENSP000003187994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ID4ENSP000003679724STRING: ENSP00000367972
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0021540corpus callosum morphogenesis IEA--
    GO:0021796cerebral cortex regionalization IEA--
    GO:0021952central nervous system projection neuron axonogenesis ----

    BHLHE22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BHLHE22 (BHE22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BHLHE22 gene: 
    NM_152414.4  

    Unigene Cluster for BHLHE22:

    Basic helix-loop-helix family, member e22
    Hs.591870  [show with all ESTs]
    Unigene Representative Sequence: NM_152414
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000321870(uc003xvi.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BHLHE22 (see all 38):
    hsa-miR-513a-5p hsa-miR-3653 hsa-miR-624 hsa-miR-192 hsa-miR-3658 hsa-miR-149 hsa-miR-29a* hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidBHLHE22 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BHLHE22
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    GenScript: all cDNA clones in your preferred vector: BHLHE22 (NM_152414)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BHLHE22
      QuantiTect SYBR Green Assays in human, mouse, rat BHLHE22
      QuantiFast Probe-based Assays in human, mouse, rat BHLHE22

    Additional mRNA sequence: 

    AK091333.1 AK293979.1 

    1 DOTS entry:

    DT.100019098 

    Selected AceView cDNA sequences (see all 36):

    BX646197 M78885 AI380496 AW665919 AI804341 AL134707 BM689628 AA453786 
    BX116391 NM_152414 BK000273 CA392856 BM661603 AA635141 AI498361 AW206610 
    AI334339 AA927689 AW594227 BC045748 AA453903 AK091333 BI552771 AI968349 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BHLHE22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTTTGAC
    BHLHE22 Expression
    About this image


    BHLHE22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             Dopaminergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             Dopaminergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
    BHLHE22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BHLHE22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591870

    UniProtKB/Swiss-Prot: BHE22_HUMAN, Q8NFJ8
    Tissue specificity: Brain-specific, with the highest expression in the cerebellum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BHLHE22 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bhlhe221 , 5 basic helix-loop-helix family, member e221, 5 85.45(n)1
    90.14(a)1
      3 (4.98 cM)5
    590581  NM_021560.41  NP_067535.31 
     180541745 
    lizard
    (Anolis carolinensis)
    Reptilia BHLHE226
    basic helix-loop-helix family, member e22
    56(a)
    1 ↔ 1
    4(30018474-30019418)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bhlhe221 basic helix-loop-helix family, member e22 72.94(n)
    75.28(a)
      780395  NM_001079465.1  NP_001072933.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc642252 similar to basic helix-loop-helix domain containing, more 79.89(n)   393930  BC053312.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oli6
    Olig family
    37(a)
    1 → many
    2L(17589407-17591267)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-326
    hlh-316
    Protein HLH-31 (hlh-31) mRNA, complete cds
    52(a)
    29(a)
    many ↔ many
    many ↔ many
    IV(16132464-16134277) WBGene00013665
    IV(16257668-16259417) WBGene00009540
    rice
    (Oryza sativa)
    Liliopsida AK100183.12   -- 76.88(n)    AK100183.1 


    ENSEMBL Gene Tree for BHLHE22 (if available)
    TreeFam Gene Tree for BHLHE22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BHLHE22 gene
    OLIG32  OLIG12  BHLHE232  OLIG22  
    2 SIMAP similar genes for BHLHE22 using alignment to 1 protein entry:     BHE22_HUMAN:
    BHLHE23    TWIST1

    BHLHE22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BHLHE22 (see all 85)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508541691,2
    C--65491887(+) CTTCCC/TGAACC 1 -- us2k10--------
    rs3751411621,2
    C--65492054(+) ACCGG-/GTTT  
            
    TTTGT
    1 -- us2k10--------
    rs2004829301,2
    C--65492070(+) TGTTTG/TCTTCC 1 -- us2k10--------
    rs47376751,2
    C,F,A,H--65492071(+) GTTTTC/TTTCCT 1 -- us2k1 tfbs3 trp318Minor allele frequency- T:0.48NS EA WA NA CSA 2339
    rs1392344551,2
    --65492521(+) ACTCCC/GAGGCT 1 -- us2k10--------
    rs1898714541,2
    C--65492570(+) ATCCTC/GGGCTC 1 -- us2k10--------
    rs1820346751,2
    --65492689(+) GCTAAA/GCTGTG 1 -- us2k10--------
    rs1499885591,2
    --65492912(+) CTCAGA/GGATAA 1 -- ut510--------
    rs1861730071,2
    --65492928(+) TAAAAC/GACTCC 1 -- ut510--------
    rs70162501,2,,4
    C,F--65493429(+) CCACCT/GCCAAG 2 /A /S mis1 ese35Minor allele frequency- G:0.36NA WA EU 477

    HapMap Linkage Disequilibrium report for BHLHE22 (65492795 - 65496191 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BHLHE22: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BHLHE22
    DNA2.0 Custom Variant and Variant Library Synthesis for BHLHE22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613483    OMIM disorders: --

    5 diseases for BHLHE22:    
    About MalaCards
    labyrinthitis    retinitis    cerebritis    neuronitis
    endotheliitis


    BHLHE22 for disorders           About GeneDecksing


    Export disorders for BHLHE22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BHLHE22 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with BHLHE22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor. (PubMed id 12213201)1, 2, 3, 9 Xu Z.-P....Saunders G.F. (Genomics 2002)
    2. Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. (PubMed id 18557763)1, 3 Stevens J.D....Skinner M.K. ( research in biological diversity 2008)
    3. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2 McLellan A.S.... Kealey T. (Mech. Dev. 2002)
    4. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 3 Margolis R.L.... Ross C.A. (Hum. Genet. 1997)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 12617822)1 McLellan A.S.... Kealey T. (Gene Expr. Patterns 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27319 HGNC: 11963 AceView: BHLHB5 Ensembl:ENSG00000180828 euGenes: HUgn27319
    ECgene: BHLHE22 H-InvDB: BHLHE22

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BHLHE22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BHLHE22 gene:
    Search GeneIP for patents involving BHLHE22

    GeneCards and IP:
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