Aliases for BHLHE22 Gene
External Ids for BHLHE22 Gene
Previous HGNC Symbols for BHLHE22 Gene
Previous GeneCards Identifiers for BHLHE22 Gene
BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM, Jul 2010]
GeneCards Summary for BHLHE22 Gene
BHLHE22 (Basic Helix-Loop-Helix Family, Member E22) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is BHLHE23.
UniProtKB/Swiss-Prot for BHLHE22 Gene
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity).