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Aliases for BHLHB9 Gene

Aliases for BHLHB9 Gene

  • Basic Helix-Loop-Helix Domain Containing, Class B, 9 2 3
  • Transcription Regulator Of 60 KDa 3 4
  • P60TRP 3 4
  • P60-Like Protein 3
  • Protein BHLHb9 3
  • KIAA1701 4
  • BHLHb9 4
  • GASP3 3

External Ids for BHLHB9 Gene

Previous GeneCards Identifiers for BHLHB9 Gene

  • GC0XP101781
  • GC0XP101865
  • GC0XP101975
  • GC0XP091573

Summaries for BHLHB9 Gene

Entrez Gene Summary for BHLHB9 Gene

  • This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for BHLHB9 Gene

BHLHB9 (Basic Helix-Loop-Helix Domain Containing, Class B, 9) is a Protein Coding gene. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot for BHLHB9 Gene

  • May play a role in the control of cellular aging and survival

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BHLHB9 Gene

Genomics for BHLHB9 Gene

Regulatory Elements for BHLHB9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BHLHB9 Gene

Start:
102,720,688 bp from pter
End:
102,753,540 bp from pter
Size:
32,853 bases
Orientation:
Plus strand

Genomic View for BHLHB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BHLHB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BHLHB9 Gene

Proteins for BHLHB9 Gene

  • Protein details for BHLHB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI77-BHLH9_HUMAN
    Recommended name:
    Protein BHLHb9
    Protein Accession:
    Q6PI77
    Secondary Accessions:
    • Q9C0G2

    Protein attributes for BHLHB9 Gene

    Size:
    547 amino acids
    Molecular mass:
    60291 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21792.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for BHLHB9 Gene

Proteomics data for BHLHB9 Gene at MOPED

Post-translational modifications for BHLHB9 Gene

  • Ubiquitination at Lys342
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BHLHB9 Gene

Domains for BHLHB9 Gene

Gene Families for BHLHB9 Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for BHLHB9 Gene

Suggested Antigen Peptide Sequences for BHLHB9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PI77

UniProtKB/Swiss-Prot:

BHLH9_HUMAN :
  • Q6PI77
Family:
  • Belongs to the GPRASP family.
genes like me logo Genes that share domains with BHLHB9: view

Function for BHLHB9 Gene

Molecular function for BHLHB9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the control of cellular aging and survival
UniProtKB/Swiss-Prot Induction:
Down-regulated in colon cancer cells, due to CpG hypermethylation of its promoter.

Gene Ontology (GO) - Molecular Function for BHLHB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with BHLHB9: view

Animal Model Products

miRNA for BHLHB9 Gene

miRTarBase miRNAs that target BHLHB9

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BHLHB9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BHLHB9 Gene

Localization for BHLHB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BHLHB9 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BHLHB9 Gene COMPARTMENTS Subcellular localization image for BHLHB9 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BHLHB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BHLHB9: view

Pathways for BHLHB9 Gene

SuperPathways for BHLHB9 Gene

No Data Available

Interacting Proteins for BHLHB9 Gene

Gene Ontology (GO) - Biological Process for BHLHB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007611 learning or memory ISS --
GO:0043524 negative regulation of neuron apoptotic process ISS --
GO:0050769 positive regulation of neurogenesis ISS --
GO:0051965 positive regulation of synapse assembly ISS --
GO:0061003 positive regulation of dendritic spine morphogenesis ISS --
genes like me logo Genes that share ontologies with BHLHB9: view

No data available for Pathways by source for BHLHB9 Gene

Transcripts for BHLHB9 Gene

Unigene Clusters for BHLHB9 Gene

Basic helix-loop-helix domain containing, class B, 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BHLHB9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BHLHB9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7:
SP8: -
SP9: -
SP10: - - - - -
SP11: - - - - - -
SP12: - - - - -

Relevant External Links for BHLHB9 Gene

GeneLoc Exon Structure for
BHLHB9
ECgene alternative splicing isoforms for
BHLHB9

Expression for BHLHB9 Gene

mRNA expression in normal human tissues for BHLHB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BHLHB9 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.1).

Protein differential expression in normal tissues for BHLHB9 Gene

This gene is overexpressed in Heart (41.1) and Retina (23.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BHLHB9 Gene

SOURCE GeneReport for Unigene cluster for BHLHB9 Gene Hs.4276

mRNA Expression by UniProt/SwissProt for BHLHB9 Gene

Q6PI77-BHLH9_HUMAN
Tissue specificity: Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease.
genes like me logo Genes that share expressions with BHLHB9: view

Expression partners for BHLHB9 Gene

In Situ Assay Products

Orthologs for BHLHB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BHLHB9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BHLHB9 35
  • 85.15 (n)
  • 77.82 (a)
dog
(Canis familiaris)
Mammalia BHLHB9 35
  • 86.89 (n)
  • 80.71 (a)
BHLHB9 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bhlhb9 35
  • 80.45 (n)
  • 74.67 (a)
Bhlhb9 16
Bhlhb9 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BHLHB9 35
  • 98.78 (n)
  • 98.77 (a)
BHLHB9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bhlhb9 35
  • 80.32 (n)
  • 74.86 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 18 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 36
  • 16 (a)
OneToMany
Species with no ortholog for BHLHB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BHLHB9 Gene

ENSEMBL:
Gene Tree for BHLHB9 (if available)
TreeFam:
Gene Tree for BHLHB9 (if available)

Paralogs for BHLHB9 Gene

Paralogs for BHLHB9 Gene

Selected SIMAP similar genes for BHLHB9 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for BHLHB9 Gene

genes like me logo Genes that share paralogs with BHLHB9: view

Variants for BHLHB9 Gene

Sequence variations from dbSNP and Humsavar for BHLHB9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1043080 -- 102,751,998(+) TGTGT(A/C)ATATG utr-variant-3-prime
rs1932929 -- 102,720,871(-) GTCGC(C/T)TGAGA intron-variant
rs2143602 -- 102,734,124(+) aggca(A/G)gaaca intron-variant
rs2179675 - 102,749,389(+) GTAAT(A/G)GTTTC reference, missense
rs2473816 -- 102,736,484(+) acagc(A/G)tggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BHLHB9 Gene

Variant ID Type Subtype PubMed ID
nsv526716 CNV Gain 19592680

Relevant External Links for BHLHB9 Gene

HapMap Linkage Disequilibrium report
BHLHB9
Locus Specific Mutation Databases (LSDB)
BHLHB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BHLHB9 Gene

Disorders for BHLHB9 Gene

No disorders were found for BHLHB9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BHLHB9 Gene

Publications for BHLHB9 Gene

  1. Characterizing the new transcription regulator protein p60TRP. (PMID: 15034937) Heese K. … Sawada T. (J. Cell. Biochem. 2004) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for BHLHB9 Gene

Sources for BHLHB9 Gene

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