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BGN Gene

protein-coding   GIFtS: 56

GC0XP152413
biglycan
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DSPG1 1, 2
OTTHUMP00000025928 2
PG-S1 2, 3
PGI 2
SLRR1A 1, 2, 3
biglycan 2
Descriptions
Bone/cartilage proteoglycan I 3
biglycan proteoglycan 2
bone/cartilage proteoglycan-I 2
dermatan sulphate proteoglycan I 2
small leucine-rich protein 1A 2
External Ids
HGNC: 10441
Entrez Gene: 6332
UniProtKB: P218103
Ensembl: ENSG000001824927
Search outside databases for aliases for BGN gene

Previous GC identifers: GC0XP146898 GC0XP149215 GC0XP150346 GC0XP151228 GC0XP152285

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BGN:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is
closely related in structure to two other small proteoglycans, decorin and fibromodulin. The
encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains
one attached glycosaminoglycan chain, while this protein probably contains two chains. For this
reason, this protein is called biglycan. This protein is thought to function in connective tissue
metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote
neuronal survival. This gene is a candidate gene for the Happle syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
Function: May be involved in collagen fiber assembly (By similarity)

Gene Wiki entry for BGN (Biglycan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BGN gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

BGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152413:     (about GC identifiers)

Start:
152,413,605 bp from pter
End:
152,428,198 bp from pter
Size:
14,594 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011726.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810 (See protein sequence)
Recommended Name: Biglycan precursor  
Size: 368 amino acids; 41654 Da
Subunit: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: P13247

Post-translational modifications:

  • The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (By
    similarity)1


  • REFSEQ proteins: NP_001702.1  

    ENSEMBL proteins: 
    ENSP00000327336 ENSP00000359223 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich CompoZr ZFN for BGN  
    R&D Systems Recombinant & Natural Proteins for BGN (Biglycan)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Biglycan)
    Human Recombinant Proteins from Abnova (BGN)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix NAS1860845
    GO:0005737 cytoplasm IDA18029348
    GO:0030133 transport vesicle IDA11256614
    About this table

    Antibodies for BGN: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for BGN
    R&D Systems Antibodies for BGN (Biglycan)
    Antibodies from Abcam (Biglycan), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BGN)
    Novus Biologicals Antibodies for BGN

    Assays for BGN: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR000372 Leu-rich_rpt_Cys-rich-reg_N
     IPR001611 Leu-rich_rpt
     IPR016352 SLRP_I_decor/aspor/byglycan


       GeneDecks  BGN for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P21810

    ProtoNet protein and cluster: P21810

    2 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily
    Similarity: Contains 12 LRR (leucine-rich) repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BGN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BGN)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001711

                  Applied Biosystems Silencer® siRNAs for BGN

                  Sigma-Aldrich siRNA and siRNA Panels for BGN  
                         Sigma-Aldrich shRNA Panels and shRNA for BGN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for BGN
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001711
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001711
                                     untagged cDNA clone in CMV expression vector: NM_001711 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001711

    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Function: May be involved in collagen fiber assembly (By similarity)

    Genatlas biochemistry entry for BGN:
    biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family

    6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bgn):

    behavior/neurologicalgrowth/sizeimmune systemlimbs/digits/tailmuscle
    skeleton

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201 extracellular matrix structural constituent NAS1860845
    GO:0005515 protein binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  BGN 

      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for BGN:
    Antagonist Ligand

    Browse Tocris compounds for BGN
    2 Novoseek chemical compound relationships for BGN gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 69.84 1 1863601 (1)
    leucine 37.78 1 1870448 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BGN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BGN)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001711

                  Sigma-Aldrich siRNA and siRNA Panels for BGN  
                         Sigma-Aldrich shRNA Panels and shRNA for BGN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001711  

    REFSEQ mRNAs for BGN gene: 

    NM_001711.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001711  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001711
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001711
                                     untagged cDNA clone in CMV expression vector: NM_001711 

    Additional cDNA sequence: 

    AK092954.1 AK093023.1 AK094059.1 AK222484.1 AK223302.1 AK291955.1 AK293268.1 AK293289.1 
    AK297966.1 AK298756.1 BC002416.2 BC004244.1 BT007323.1 CR595264.1 CR618469.1 CR624916.1 
    J04599.1 U11686.1 

    24/48 DOTS entries (see all 48 ):

    DT.455904  DT.86995097  DT.100877240  DT.100877223  DT.100804711  DT.99943230  DT.100877226  DT.97860449 
    DT.95122348  DT.100031288  DT.97860448  DT.100877237  DT.121287231  DT.85103514  DT.121287285  DT.91657188 
    DT.121287209  DT.95122339  DT.91761196  DT.100877242  DT.100723142  DT.121287265  DT.100877233  DT.91816029 

    24/767 AceView cDNA sequences (see all 767 ):

    BQ708804 BP372124 AU103050 BQ181055 AU142104 NM_001711 CR618469 BP372907 
    AU141310 AU142113 BQ882271 BX365355 BQ955417 C02866 BG681579 AW130808 
    AA348704 BP374504 BX358489 CN484687 R32356 AA554050 BI753916 BF925736 

    highest scoring ESTs for BGN:

    AW007442 J04599 R77227 AA317049 AA336870 AA348703 AA348704 AA359111 AA401265 AA404245 

    Unigene Cluster for BGN:

    Biglycan
    Hs.821  [show with all ESTs]
    Unigene Representative Sequence: BC004244


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BGN (see all 11 )

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^
    SP1:                                                                          -                                                                                 
    SP2:              -     -                                                     -                                                                                 
    SP3:              -     -                                               -     -     -     -                                                                     
    SP4:              -     -                 -     -                             -                                                                                 
    SP5:                                                                          -                                                                                 

    ExUns: 12a · 12b · 12c · 12d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for BGN

    2 Ensembl transcripts including schematic representations:
    ENST00000331595  ENST00000370204  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BGN expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BGN

    1 / 2 / 3

    9 probe-sets matching BGN gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    38126_at2, 3 U95-A 1 1.00 1.00 0.98 0.93 J04599 1.00 0.90 0.95 1

    74989_at2, 3 U95-D 2 1.00 0.94 0.98 1.02 AW007442 1.00 0.90 0.95 1

    89603_at2, 3 U95-E 1 0.88 1.00 1.00 1.06 R77227 1.00 0.90 0.95 1

    201262_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001711 0.60 1.00 0.82 1

    201261_x_at2, 3 U133-A 3 1.00 0.94 -- -- BC002416 0.80 1.00 0.91 1

    213905_x_at2, 3 U133-A 1 0.91 1.00 -- -- AA845258 0.40 1.00 0.76 1

    201262_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201261_x_at2 U133Plus2 3 1.00 0.94 -- -- -- -- -- -- --

    213905_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCTGTCCCT

    SOURCE GeneReport for Unigene cluster: Hs.821

    Expression variation in blood from EXPOLDB for BGN

    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Tissue specificity: Found in several connective tissues, especially in articular cartilages

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BGN gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BGN1   -- biglycan 91.85(n)
    94.84(a)
    403905  NM_001003229.1  NP_001003229.1 
    chimpanzee
    (Pan troglodytes)
    BGN1   -- biglycan 99.23(n)
    100(a)
    473829  XM_529202.2  XP_529202.2 
    cow
    (Bos taurus)
    BGN1   -- biglycan 90.85(n)
    94.84(a)
    280733  NM_178318.3  NP_847888.2 
    rat
    (Rattus norvegicus)
    Bgn1   -- biglycan 88.59(n)
    95.65(a)
    25181  NM_017087.1  NP_058783.1 
    mouse
    (Mus musculus)
    Bgn1, 5 X (29.30 cM)5
    biglycan1, 5 88.59(n)1
    95.92(a)1
    121111  NM_007542.31  NP_031568.21 
     AK0869205  AK1354965  (see all 19)
    About this table        Species with no ortholog for BGN

    ENSEMBL Gene Tree for BGN
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BGN gene
    DCN2  ECM22  ASPN2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/129 NCBI SNPs in BGN are shown (see all 129 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 63)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs7436421,2
    A,C,F,H,O152427415(+) CCAAGG/TCTCCA 1 -- ut31 ese316Minor allele frequency- T:0.25EA NA EU WA 1194
    rs37616471,2
    A,C,F,H152412164(+) AGCCAC/TCTCCT 1 -- ng517Minor allele frequency- N:0.00EA WA NA 514
    rs7436411,2
    A,C,F,H152427348(+) CTCCCA/TCCACA 1 -- ut31 ese37Minor allele frequency- T:0.30EA WA NA 658
    rs125593781,2
    A,C,H152412464(+) CCCACC/TCCCCG 1 -- ng51 tfbs34Minor allele frequency- T:0.00EU EA WA 412
    rs10421031,2
    A,F,H152427225(+) ACCTCG/AGGTCC 1 -- ut314Minor allele frequency- A:0.13EU EA WA 418
    rs117969971,2
    C,F152413055(+) GTCTGG/AAGTGG 1 -- ng511Minor allele frequency- A:0.23NA 65
    rs120125451,2
    C,H152411719(+) gagcaC/Tgtaca 1 -- ng514Minor allele frequency- T:0.00EU EA WA 408
    rs31770001,2
    F152428186(+) GAAACA/CCCGTG 1 -- ut31 ese31Minor allele frequency- C:0.01MN 184
    rs30209751,2
    A152412007(+) GCTTCA/GCTGCC 1 -- ng510--------
    --
    rs59451971,2
    F152413726(+) AGCCCG/TCCAAC 1 -- ut51 ese31Minor allele frequency- T:0.32MN 184
    About this table

    HapMap Linkage Disequilibrium images for BGN (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 301870

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/71 PubMed articles for BGN gene (see all 71 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 633 HGNC: 1044 AceView: BGN Ensembl:ENSG00000182492 euGenes: HUgn633
    ECgene: BGN H-InvDB: BGN
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BGN:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for BGN Antibodies for BGN
     Explore super-pooled esiRNAs Proteins for BGN
     Lentivirus-delivered shRNAs for BGN Small molecules for BGN
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Biglycan)
     Antibodies (Biglycan)
     Search OriGene for BGN
     Search Tocris compounds for BGN




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for BGN

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