Aliases for BGN Gene
External Ids for BGN Gene
Previous GeneCards Identifiers for BGN Gene
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
GeneCards Summary for BGN Gene
BGN (Biglycan) is a Protein Coding gene. Diseases associated with BGN include renal artery atheroma and exposure keratitis. Among its related pathways are Articular Cartilage Extracellular Matrix Pathway and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix binding. An important paralog of this gene is ECM2.
UniProtKB/Swiss-Prot for BGN Gene
May be involved in collagen fiber assembly.