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Aliases for BGN Gene

Aliases for BGN Gene

  • Biglycan 2 3
  • Bone/Cartilage Proteoglycan I 3 4
  • Biglycan Proteoglycan 2 3
  • SLRR1A 3 4
  • PG-S1 3 4
  • Dermatan Sulphate Proteoglycan I 3
  • Bone/Cartilage Proteoglycan-I 3
  • Small Leucine-Rich Protein 1A 3
  • DSPG1 3
  • PGI 3

External Ids for BGN Gene

Previous GeneCards Identifiers for BGN Gene

  • GC0XP146898
  • GC0XP149215
  • GC0XP150346
  • GC0XP151228
  • GC0XP152285
  • GC0XP152413
  • GC0XP152762
  • GC0XP141428

Summaries for BGN Gene

Entrez Gene Summary for BGN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]

GeneCards Summary for BGN Gene

BGN (Biglycan) is a Protein Coding gene. Diseases associated with BGN include renal artery atheroma and exposure keratitis. Among its related pathways are Infectious disease and Degradation of the extracellular matrix. GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for BGN Gene

  • May be involved in collagen fiber assembly.

Gene Wiki entry for BGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BGN Gene

Genomics for BGN Gene

Regulatory Elements for BGN Gene

Genomic Location for BGN Gene

Chromosome:
X
Start:
153,494,889 bp from pter
End:
153,509,554 bp from pter
Size:
14,666 bases
Orientation:
Plus strand

Genomic View for BGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BGN Gene

Proteins for BGN Gene

  • Protein details for BGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21810-PGS1_HUMAN
    Recommended name:
    Biglycan
    Protein Accession:
    P21810
    Secondary Accessions:
    • D3DWU3
    • P13247

    Protein attributes for BGN Gene

    Size:
    368 amino acids
    Molecular mass:
    41654 Da
    Quaternary structure:
    • Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).

neXtProt entry for BGN Gene

Proteomics data for BGN Gene at MOPED

Post-translational modifications for BGN Gene

  • The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
  • Glycosylation at Ser 42, Ser 47, Ser 180, Ser 198, Asn 270, and Asn 311
  • Modification sites at PhosphoSitePlus

Other Protein References for BGN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BGN Gene

Domains & Families for BGN Gene

Gene Families for BGN Gene

Suggested Antigen Peptide Sequences for BGN Gene

Graphical View of Domain Structure for InterPro Entry

P21810

UniProtKB/Swiss-Prot:

PGS1_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Contains 12 LRR (leucine-rich) repeats.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with BGN: view

Function for BGN Gene

Molecular function for BGN Gene

GENATLAS Biochemistry:
biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family
UniProtKB/Swiss-Prot Function:
May be involved in collagen fiber assembly.

Gene Ontology (GO) - Molecular Function for BGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent NAS 1860845
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with BGN: view
genes like me logo Genes that share phenotypes with BGN: view

Animal Models for BGN Gene

MGI Knock Outs for BGN:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BGN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BGN Gene

Localization for BGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for BGN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BGN Gene COMPARTMENTS Subcellular localization image for BGN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for BGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix NAS 1860845
GO:0005622 intracellular --
GO:0005796 Golgi lumen TAS --
GO:0009986 cell surface IDA 2212616
genes like me logo Genes that share ontologies with BGN: view

Pathways & Interactions for BGN Gene

genes like me logo Genes that share pathways with BGN: view

Pathways by source for BGN Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for BGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0008150 biological_process ND --
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with BGN: view

No data available for SIGNOR curated interactions for BGN Gene

Drugs & Compounds for BGN Gene

(3) Drugs for BGN Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Chondroitin Nutra 40
leucine Nutra 93
genes like me logo Genes that share compounds with BGN: view

Transcripts for BGN Gene

Unigene Clusters for BGN Gene

Biglycan:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BGN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BGN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: -
SP10: - -
SP11: - - - - - - -

ExUns: 12a · 12b · 12c · 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for BGN Gene

GeneLoc Exon Structure for
BGN
ECgene alternative splicing isoforms for
BGN

Expression for BGN Gene

mRNA expression in normal human tissues for BGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BGN Gene

This gene is overexpressed in Artery - Aorta (x14.8), Artery - Coronary (x8.7), and Artery - Tibial (x6.3).

Protein differential expression in normal tissues from HIPED for BGN Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (16.0), Breast (10.1), Skin (7.9), Spinal cord (7.8), and Gallbladder (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BGN Gene



SOURCE GeneReport for Unigene cluster for BGN Gene Hs.821

mRNA Expression by UniProt/SwissProt for BGN Gene

P21810-PGS1_HUMAN
Tissue specificity: Found in several connective tissues, especially in articular cartilages
genes like me logo Genes that share expression patterns with BGN: view

Protein tissue co-expression partners for BGN Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for BGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for BGN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BGN 35
  • 90.85 (n)
  • 94.84 (a)
BGN 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BGN 35
  • 91.85 (n)
  • 94.84 (a)
BGN 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bgn 35
  • 88.59 (n)
  • 95.92 (a)
Bgn 16
Bgn 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BGN 35
  • 99.01 (n)
  • 99.67 (a)
BGN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bgn 35
  • 88.59 (n)
  • 95.65 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia BGN 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bgn 35
  • 70.38 (n)
  • 77.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.939 35
zebrafish
(Danio rerio)
Actinopterygii bgnb 35
  • 69.66 (n)
  • 72.47 (a)
Dr.16232 35
bgna 36
  • 66 (a)
OneToMany
bgnb 36
  • 69 (a)
OneToMany
Species with no ortholog for BGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BGN Gene

ENSEMBL:
Gene Tree for BGN (if available)
TreeFam:
Gene Tree for BGN (if available)

Paralogs for BGN Gene

Paralogs for BGN Gene

(5) SIMAP similar genes for BGN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BGN: view

Variants for BGN Gene

Sequence variations from dbSNP and Humsavar for BGN Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4833 -- 153,504,772(+) ACCTC(A/G)GGCGT synonymous-codon, reference
rs743641 -- 153,508,696(+) CTCCC(A/T)CCACA utr-variant-3-prime
rs743642 -- 153,508,763(+) CCAAG(G/T)CTCCA utr-variant-3-prime
rs1126499 -- 153,506,051(+) TTCAG(C/T)GGGCT reference, synonymous-codon
rs1126598 -- 153,509,059(+) TCTCT(C/G/T)TCTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BGN Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
nsv522600 CNV Gain 19592680

Variation tolerance for BGN Gene

Residual Variation Intolerance Score: 17.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BGN Gene

HapMap Linkage Disequilibrium report
BGN
Human Gene Mutation Database (HGMD)
BGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BGN Gene

Disorders for BGN Gene

MalaCards: The human disease database

(5) MalaCards diseases for BGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal artery atheroma
  • atherosclerosis of renal artery
exposure keratitis
  • lagophthalmic keratitis
dentin caries
  • dental caries extending into dentine
achondrogenesis ib
  • achondrogenesis type ib
dental pulp calcification
  • pulp calcifications
- elite association
Search BGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for BGN

Genetic Association Database (GAD)
BGN
Human Genome Epidemiology (HuGE) Navigator
BGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BGN
genes like me logo Genes that share disorders with BGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BGN Gene

Publications for BGN Gene

  1. Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. (PMID: 19723327) Dehne T. … Lindahl A. (Arthritis Res. Ther. 2009) 23 67
  2. Differences in mRNA and protein expression of small proteoglycans in vaginal wall tissue from women with and without stress urinary incontinence. (PMID: 17395685) Wen Y. … Chen B.H. (Hum. Reprod. 2007) 23 67
  3. Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction. (PMID: 17032449) Clements D.N. … Day P.J. (Arthritis Res. Ther. 2006) 23 67
  4. Glycosaminoglycans and proteoglycans in the skin of aneuploid fetuses with increased nuchal translucency. (PMID: 14645170) von Kaisenberg C.S. … Brand-Saberi B. (Hum. Reprod. 2003) 23 67
  5. Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling. (PMID: 12538652) Ungefroren H. … Kalthoff H. (J. Biol. Chem. 2003) 23 67

Products for BGN Gene

Sources for BGN Gene

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