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BGN Gene

protein-coding   GIFtS: 65
GCID: GC0XP152762

Biglycan

  See BGN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
biglycan1 2     DSPG12
Biglycan Proteoglycan1 2     PGI2
Bone/Cartilage Proteoglycan I2 3     Bone/Cartilage Proteoglycan-I2
PG-S12 3     Dermatan Sulphate Proteoglycan I2
SLRR1A2 3     Small Leucine-Rich Protein 1A2

External Ids:    HGNC: 10441   Entrez Gene: 6332   Ensembl: ENSG000001824927   OMIM: 3018705   UniProtKB: P218103   
ORGUL members:         

Export aliases for BGN gene to outside databases

Previous GC identifers: GC0XP146898 GC0XP149215 GC0XP150346 GC0XP151228 GC0XP152285 GC0XP152413 GC0XP141428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BGN Gene:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related
in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are
thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this
protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role
in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular
dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the
assembly of the dystrophin-associated protein complex. (provided by RefSeq, Nov 2009)

GeneCards Summary for BGN Gene:
BGN (biglycan) is a protein-coding gene. Diseases associated with BGN include exposure keratitis. GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix binding. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
Function: May be involved in collagen fiber assembly (By similarity)

Gene Wiki entry for BGN (Biglycan) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the BGN gene promoter:
         GR   GR-beta   MyoD   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBGN promoter sequence
   Search Chromatin IP Primers for BGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

BGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BGN gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152762:  view genomic region     (about GC identifiers)

Start:
152,760,347 bp from pter      End:
152,775,012 bp from pter
Size:
14,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810 (See protein sequence)
Recommended Name: Biglycan precursor  
Size: 368 amino acids; 41654 Da
Subunit: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity)
Secondary accessions: D3DWU3 P13247

Explore the universe of human proteins at neXtProt for BGN: NX_P21810

Explore proteomics data for BGN at MOPED

Post-translational modifications: 

  • The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (By similarity)1
  • Glycosylation2 at Ser42, Ser47, Ser180, Ser198, Asn270, Asn311
  • Modification sites at PhosphoSitePlus

  • See BGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001702.1  
    ENSEMBL proteins: 
     ENSP00000327336   ENSP00000402525  
    Reactome Protein details: P21810

    BGN Human Recombinant Protein Products:

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    Novus Biologicals BGN Proteins
    Novus Biologicals BGN Lysates
    Sino Biological Recombinant Protein for BGN
    Sino Biological Cell Lysate for BGN
    ProSpec Recombinant Protein for BGN
    Cloud-Clone Corp. Proteins for BGN

     
    Search eBioscience for Proteins for BGN 

    BGN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BGN (Biglycan)
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    Abcam antibodies for BGN
    Cloud-Clone Corp. Antibodies for BGN
    ThermoFisher Antibodies for BGN
    LSBio Antibodies in human, mouse, rat for BGN

    BGN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for BGN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BGN
    Cloud-Clone Corp. CLIAs for BGN
    Search eBioscience for ELISAs for BGN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    4 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR028547 Biglycan
     IPR000372 LRR-contain_N
     IPR016352 SLRP_I_decor/aspor/byglycan

    Graphical View of Domain Structure for InterPro Entry P21810

    ProtoNet protein and cluster: P21810

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily
    Similarity: Contains 12 LRR (leucine-rich) repeats


    Find genes that share domains with BGN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGS1_HUMAN, P21810
    Function: May be involved in collagen fiber assembly (By similarity)

         Genatlas biochemistry entry for BGN:
    biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent NAS1860845
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding IEA--
    GO:0050840extracellular matrix binding IEA--
         
    Find genes that share ontologies with BGN           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bgn):
     behavior/neurological  growth/size/body  immune system  integument  limbs/digits/tail 
     mortality/aging  muscle  reproductive system  skeleton 

    Find genes that share phenotypes with BGN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bgntm1Mfy for BGN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BGN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BGN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BGN

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BGN:
    hsa-miR-185* hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidBGN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat BGN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BGN (NM_001711)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BGN

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BGN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGS1_HUMAN, P21810: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    lysosome4
    vacuole4
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    mitochondrion2
    plasma membrane2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix NAS1860845
    GO:0005622intracellular ----
    GO:0005796Golgi lumen TAS--
    GO:0009986cell surface IDA2212616

    Find genes that share ontologies with BGN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BGN About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    CS/DS degradation0.00
    A tetrasaccharide linker sequence is required for GAG synthesis0.51
    Dermatan sulfate biosynthesis0.00
    Chondroitin sulfate biosynthesis0.41
    3Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with BGN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BGN
        Articular Cartilage Extracellular Matrix


    2 Sino Biological Pathways for BGN
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5 Reactome Pathways for BGN
        Dermatan sulfate biosynthesis
    ECM proteoglycans
    CS/DS degradation
    A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate biosynthesis


        Pathway & Disease-focused RT2 Profiler PCR Arrays including BGN: 
              Osteogenesis in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BGN (P218103 ENSP000003273364) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228321P013753, ENSP000003928584I2D: score=3 STRING: ENSP00000392858
    TNFP013753, ENSP000003986984I2D: score=3 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=3 
    ENSG00000206439P013753I2D: score=3 
    ENSG00000223952P013753I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0008150biological_process ND--
    GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with BGN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BGN (PGS1)

    3 Novoseek inferred chemical compound relationships for BGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 68.4 1 1863601 (1)
    leucine 35.6 1 1870448 (1)
    dexamethasone 27.8 7 7988427 (6)



    Find genes that share compounds with BGN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BGN gene: 
    NM_001711.4  

    Unigene Cluster for BGN:

    Biglycan
    Hs.821  [show with all ESTs]
    Unigene Representative Sequence: NM_001711
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331595(uc004fhr.2) ENST00000472615 ENST00000480756 ENST00000431891
    ENST00000492658
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BGN:
    hsa-miR-185* hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidBGN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BGN
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    GenScript: all cDNA clones in your preferred vector: BGN (NM_001711)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BGN
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BGN
      QuantiTect SYBR Green Assays in human, mouse, rat BGN
      QuantiFast Probe-based Assays in human, mouse, rat BGN

    Additional mRNA sequence: 

    AK092954.1 AK093023.1 AK094059.1 AK222484.1 AK223302.1 AK291955.1 AK293268.1 AK293289.1 
    AK297966.1 AK298756.1 BC002416.2 BC004244.1 BT007323.1 J04599.1 U11686.1 

    Selected DOTS entries (see all 53):

    DT.86995097  DT.455904  DT.100877240  DT.100877223  DT.100804711  DT.99943230  DT.100877226  DT.97860449 
    DT.95122348  DT.100031288  DT.97860448  DT.100877237  DT.121287231  DT.85103514  DT.121287285  DT.91657188 
    DT.121287209  DT.95122339  DT.100723142  DT.91761196  DT.100877242  DT.121287265  DT.121643522  DT.100877231 

    Selected AceView cDNA sequences (see all 767):

    BU185997 BP372343 CD612580 BP372124 BP372385 AU141310 BI041055 R32356 
    NM_001711 BP375184 BQ067023 BF930532 AA336870 BP374504 BQ882271 BM856447 
    BP372907 AU142113 BQ942694 BQ708510 AA554050 BU736310 BQ955417 BP365987 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BGN (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^
    SP1:                                                                          -                                                                                 
    SP2:              -     -                                                     -                                                                                 
    SP3:              -     -                                               -     -     -     -                                                                     
    SP4:              -     -                 -     -                             -                                                                                 
    SP5:                                                                          -                                                                                 

    ExUns: 12a · 12b · 12c · 12d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for BGN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGTCCCT
    BGN Expression
    About this image


    BGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 4 entries
             Early Tenocyte Cells Limb Tendon Primordia
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Dermis (Integumentary System)    fully expand to see all 5 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
             Detroit 551
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Odontoblasts Dentin
             Dentin
    BGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.821

    UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810
    Tissue specificity: Found in several connective tissues, especially in articular cartilages

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BGN: 
              Osteogenesis in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat BGN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BGN gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bgn1 , 5 biglycan1, 5 88.59(n)1
    95.92(a)1
      X (37.33 cM)5
    121111  NM_007542.41  NP_031568.21 
     734836025 
    lizard
    (Anolis carolinensis)
    Reptilia BGN6
    biglycan
    81(a)
    1 ↔ 1
    2(87393940-87426153)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9392 Xenopus laevis BGN mRNA for biglycan, complete cds 78.87(n)    AB037269.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.162322 Danio rerio cDNA clone IMAGE6795018, partial cds 77.94(n)    BC054617.1 


    ENSEMBL Gene Tree for BGN (if available)
    TreeFam Gene Tree for BGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BGN gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  OMD2  
    ASPN2  DCN2  FLRT22  ECM22  LOC1005090912  LUM2  
    5 SIMAP similar genes for BGN using alignment to 2 protein entries:     PGS1_HUMAN (see all proteins):
    ASPN    DCN    LRIG3    SLIT2    LUM

    Find genes that share paralogs with BGN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BGN (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366054
    A breast cancer sample4--see VAR_0366052 R T mis40--------
    VAR_0366064
    A breast cancer sample4--see VAR_0366062 K N mis40--------
    rs1497044081,2
    C--152634028(+) ATGTAA/TGTGTA 1 -- int10--------
    rs1843670641,2
    --152634033(+) TGTGTA/GTATGT 1 -- int10--------
    rs625941191,2
    C,F--152634069(+) TATGCG/ATGTGT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1877660361,2
    --152634114(+) GTATGC/TGTGTA 1 -- int10--------
    rs1917434041,2
    --152634131(+) TGTATA/GTGTGC 1 -- int10--------
    rs2006866711,2
    C--152634170(+) ATGCA-/TGTGTGT 1 -- int10--------
    rs1121224991,2
    C--152634174(+) ATGTGC/TGTGTG 1 -- int13Minor allele frequency- T:0.00NA CSA 3
    rs70645371,2
    A--152634203(+) tgtgtA/Gtgtgt 1 -- int10--------

    HapMap Linkage Disequilibrium report for BGN (152760347 - 152775012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BGN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522600CNV Gain19592680
    esv33199CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): BGN
    Locus Specific Mutation Databases (LSDB): BGN

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BGN
    DNA2.0 Custom Variant and Variant Library Synthesis for BGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 301870    OMIM disorders: --

    1 disease for BGN:    
    About MalaCards
    exposure keratitis

    4 diseases from the University of Copenhagen DISEASES database for BGN:
    Osteoarthritis     Atherosclerosis     Exposure keratitis     Ehlers-Danlos syndrome

    Find genes that share disorders with BGN           About GenesLikeMe

    Genetic Association Database (GAD): BGN
    Human Genome Epidemiology (HuGE) Navigator: BGN (6 documents)

    Export disorders for BGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BGN gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with BGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 2 Mallon A.-M....Brown S.D.M. (Genome Res. 2000)
    4. Dinucleotide repeat polymorphism at the human biglycan (BGN) locus. (PubMed id 7881444)1, 2 Just W.... Vogel W. (Hum. Mol. Genet. 1994)
    5. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. (PubMed id 1612609)1, 3 Traupe H....Ropers H.H. (Genomics 1992)
    6. Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. (PubMed id 1860845)1, 2 Fisher L.W.... Young M.F. (J. Biol. Chem. 1991)
    7. Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. (PubMed id 2590169)1, 2 Roughley P.J. and White R.J. (Biochem. J. 1989)
    8. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. (PubMed id 2647739)1, 2 Fisher L.W.... Young M.F. (J. Biol. Chem. 1989)
    9. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)1, 2 Fisher L.W.... Termine J.D. (J. Biol. Chem. 1987)
    10. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. (PubMed id 12140283)1, 9 Chen W.B....Ungefroren H. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 633 HGNC: 1044 AceView: BGN Ensembl:ENSG00000182492 euGenes: HUgn633
    ECgene: BGN H-InvDB: BGN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BGN gene:
    Search GeneIP for patents involving BGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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