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Aliases & Descriptions for BGN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DSPG1 1, 2 | | OTTHUMP00000025928 2 | | PG-S1 2, 3 | | PGI 2 | | SLRR1A 1, 2, 3 | | biglycan 2 |
| | | Descriptions |
|---|
| Bone/cartilage proteoglycan I 3 | | biglycan proteoglycan 2 | | bone/cartilage proteoglycan-I 2 | | dermatan sulphate proteoglycan I 2 | | small leucine-rich protein 1A 2 |
|
| | Search outside databases for aliases for BGN genePrevious GC identifers: GC0XP146898 GC0XP149215 GC0XP150346 GC0XP151228 GC0XP152285 |
Summaries for BGN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BGN: The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. This gene is a candidate gene for the Happle syndrome. [provided by RefSeq] UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810Function: May be involved in collagen fiber assembly (By similarity)Gene Wiki entry for BGN (Biglycan) |
Genomic Location for BGN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BGN gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28BGN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP152413:
(about GC identifiers)
Start:
|
152,413,605 bp from pter |
End:
|
152,428,198 bp from pter |
Size:
|
14,594 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins for BGN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810 (See
protein sequence)Recommended Name: Biglycan precursor Size: 368 amino acids; 41654 Da
Subunit: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: P13247Post-translational modifications:
The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (By similarity)1
REFSEQ proteins: NP_001702.1
ENSEMBL proteins: ENSP00000327336 ENSP00000359223
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for BGN: Assays for BGN: | Protein
Domains/ Families for BGN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P21810
ProtoNet protein and cluster: P21810 2 Blocks protein families: IPB000372 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamilySimilarity: Contains 12 LRR (leucine-rich) repeats | Gene Function for BGN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001711
Applied Biosystems Silencer® siRNAs for BGN
Sigma-Aldrich siRNA and siRNA Panels for BGN  Sigma-Aldrich shRNA Panels and shRNA for BGN  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001711                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001711                                  untagged cDNA clone in CMV expression vector: NM_001711 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001711
UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810Function: May be involved in collagen fiber assembly (By similarity)Genatlas biochemistry entry for BGN:biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bgn):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005201 | extracellular matrix structural constituent |
NAS | 1860845 | | GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for BGN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BGN 
--1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for BGN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BGN 2 Novoseek chemical compound relationships for BGN gene
About this table
|
Transcripts for BGN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001711
Sigma-Aldrich siRNA and siRNA Panels for BGN  Sigma-Aldrich shRNA Panels and shRNA for BGN  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001711 REFSEQ mRNAs for BGN gene: NM_001711.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001711               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001711                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001711                                  untagged cDNA clone in CMV expression vector: NM_001711  Additional cDNA sequence: AK092954.1 AK093023.1 AK094059.1 AK222484.1 AK223302.1 AK291955.1 AK293268.1 AK293289.1 AK297966.1 AK298756.1 BC002416.2 BC004244.1 BT007323.1 CR595264.1 CR618469.1 CR624916.1 J04599.1 U11686.1 24/48 DOTS entries (see all 48
): DT.455904 DT.86995097 DT.100877240 DT.100877223 DT.100804711 DT.99943230 DT.100877226 DT.97860449 DT.95122348 DT.100031288 DT.97860448 DT.100877237 DT.121287231 DT.85103514 DT.121287285 DT.91657188 DT.121287209 DT.95122339 DT.91761196 DT.100877242 DT.100723142 DT.121287265 DT.100877233 DT.91816029 24/767 AceView cDNA sequences (see all 767
):BQ708804 BP372124 AU103050 BQ181055 AU142104 NM_001711 CR618469 BP372907 AU141310 AU142113 BQ882271 BX365355 BQ955417 C02866 BG681579 AW130808 AA348704 BP374504 BX358489 CN484687 R32356 AA554050 BI753916 BF925736
highest scoring ESTs for BGN:AW007442 J04599 R77227 AA317049 AA336870 AA348703 AA348704 AA359111 AA401265 AA404245 Unigene Cluster for BGN: Biglycan Hs.821 [show with all ESTs]Unigene Representative Sequence: BC004244
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BGN (see all 11
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 12a | · | 12b | · | 12c | · | 12d | |
| SP1: | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BGN
2 Ensembl transcripts including schematic representations: ENST00000331595
ENST00000370204
|
Expression for BGN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BGN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BGN
1 / 2 / 3 9 probe-sets matching BGN gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCTGTCCCT
SOURCE GeneReport for Unigene cluster: Hs.821
Expression variation in blood from EXPOLDB for BGN UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810Tissue specificity: Found in several connective tissues, especially in articular cartilages |
Orthologs for BGN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BGN gene from 5/7 species (see all 7
)
About this table Species with no ortholog for BGN
ENSEMBL Gene Tree for BGN | Paralogs for BGN(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BGN gene
- DCN2 ECM22 ASPN2
|
SNPs/Variants for BGN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BGN (up to first 250kb)
|
Disorders & Mutations for BGN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 301870
|
Medical News for BGN(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BGN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/71 PubMed articles for BGN gene (see all 71
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PubMed id 10854409)3, 4 Mallon A.M....Brown S.D. (2000)
- Dinucleotide repeat polymorphism at the human biglycan (BGN) locus. (PubMed id 7881444)3, 4 Just W.... Vogel W. (1994)
- Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. (PubMed id 1612609)2, 3 Traupe H....Ropers H.H. (1992)
- Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. (PubMed id 1860845)3, 4 Fisher L.W.... Young M.F. (1991)
- Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. (PubMed id 2590169)3, 4 Roughley P.J. and White R.J. (1989)
- Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. (PubMed id 2647739)3, 4 Fisher L.W.... Young M.F. (1989)
- Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)3, 4 Fisher L.W.... Termine J.D. (1987)
- Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. (PubMed id 12140283)1, 3 Chen W.B....Ungefroren H. (2002)
- Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling. (PubMed id 12538652)1, 3 Ungefroren H....Kalthoff H. (2003)
|
Search for BGN
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BGN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BGN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BGN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BGN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BGN:

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Incremental update: 13 Oct 2009
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