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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BGN Gene

protein-coding GIFtS: 61
GCID: GC0XP152762

biglycan

Explore 22 diseases affiliated with
BGN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Biglycan¹		PGI²
SLRR1A¹ ² ³		Biglycan Proteoglycan²
DSPG1¹ ²		Bone/Cartilage Proteoglycan-I²
Bone/Cartilage Proteoglycan I² ³		Dermatan Sulphate Proteoglycan I²
PG-S1² ³		Small Leucine-Rich Protein 1A²

External Ids:	HGNC: 1044¹	Entrez Gene: 633²	Ensembl: ENSG00000182492⁷	OMIM: 301870⁵	UniProtKB: P21810³

Export aliases for BGN gene to outside databases

Previous GC identifers: GC0XP146898 GC0XP149215 GC0XP150346 GC0XP151228 GC0XP152285 GC0XP152413 GC0XP141428

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BGN:

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in

structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to

be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein

probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly

of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy,

including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the

dystrophin-associated protein complex. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810

Function: May be involved in collagen fiber assembly (By similarity)

Gene Wiki entry for BGN (Biglycan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167198.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BGN gene promoter:
GR GR-beta MyoD GR-alpha NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BGN promoter sequence

Search SABiosciences Chromatin IP Primers for BGN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BGN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

BGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BGN gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP152762: view genomic region (about GC identifiers)

Start:	152,760,347 bp from pter	End:	152,775,012 bp from pter
Size:	14,666 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810 (See protein sequence)

Recommended Name: Biglycan precursor

Size: 368 amino acids; 41654 Da

Subunit: Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: D3DWU3 P13247

Explore the universe of human proteins at neXtProt for BGN: NX_P21810

Post-translational modifications:

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21810

BGN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001702.1

ENSEMBL proteins:

ENSP00000327336 ENSP00000402525 ENSP00000359223

Reactome Protein details: P21810
Human Recombinant Protein Products:

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	Novus Biologicals BGN Protein Novus Biologicals BGN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BGN

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	NAS	1860845
GO:0005796	Golgi lumen	TAS	--
GO:0009986	cell surface	IDA	2212616
GO:0030133	transport vesicle	IDA	--

BGN for ontologies About GeneDecksing

BGN Antibody Products:

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	Novus Biologicals BGN Antibodies
	Abcam antibodies for BGN
	Uscn Antibodies for BGN
	ThermoFisher Antibodies for BGN

Assay Products for BGN:

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	GenScript Custom Assay Services for BGN
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	Uscn ELISAs and CLIAs for BGN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BGN for domains About GeneDecksing

3 InterPro domains/families:

IPR000372 LRR-contain_N

IPR001611 Leu-rich_rpt

IPR016352 SLRP_I_decor/aspor/byglycan

Graphical View of Domain Structure for InterPro Entry P21810

ProtoNet protein and cluster: P21810

2 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810

Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily

Similarity: Contains 12 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810

Function: May be involved in collagen fiber assembly (By similarity)

Genatlas biochemistry entry for BGN:

biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family

miRNA Products:		OriGene 3'-UTR Clone: BGN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BGN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate BGN:
		hsa-miR-185* hsa-miR-486-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BGN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BGN (see all 7) OriGene shRNA RFP: BGN OriGene siRNA: BGN
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BGN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: BGN (NM_001711)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BGN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BGN
		Search LifeMap BioReagents cell lines for BGN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BGN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	1860845
GO:0005539	glycosaminoglycan binding	IEA	--
GO:0050840	extracellular matrix binding	IEA	--

BGN for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Bgn^tm1Mfy for BGN
     9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bgn):

behavior/neurological	growth/size	immune system	integument	limbs/digits/tail
mortality/aging	muscle	reproductive system	skeleton

BGN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/15 pathways (see all 15)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00
MPS IV - Morquio syndrome A	1.00	Glycosaminoglycan metabolism	1.00

DSPGs are secreted

DSPG and CSPG translocate to the lysosome for degradation	1.00	CSPG is secreted	1.00
DSPGs are secreted	1.00	Dermatan sulfate biosynthesis	0.70
CS is cleaved from its proteoglycan	1.00	CS/DS degradation	0.54
DS is cleaved from its proteoglycan	1.00

A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis

1.00

Chondroitin sulfate/dermatan sulfate metabolism

0.54

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for BGN

Articular Cartilage Extracellular Matrix

5/27 Reactome Pathways for BGN (see all 27)

	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	DSPG and CSPG translocate to the lysosome for degradation
	Disease

BGN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BGN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for BGN (P21810³ ENSP00000327336⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOB	P04114³, ENSP00000233242⁴	I2D: score=2 STRING: ENSP00000233242
APP	P05067³, ENSP00000284981⁴	I2D: score=2 STRING: ENSP00000284981
MFAP2	P55001³, ENSP00000364685⁴	I2D: score=2 STRING: ENSP00000364685
BMP4	P12644³, ENSP00000245451⁴	I2D: score=1 STRING: ENSP00000245451
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=1 STRING: ENSP00000225964

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001974	blood vessel remodeling	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0008150	biological_process	ND	--
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	IEA	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--

BGN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BGN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BGN
3 Novoseek chemical compound relationships for BGN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin	68.4	1	1863601 (1)
leucine	35.6	1	1870448 (1)
dexamethasone	27.8	7	7988427 (6)

Search CenterWatch for drugs/clinical trials and news about BGN / PGS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BGN gene:

NM_001711.4

Unigene Cluster for BGN:

Biglycan

Hs.821 [show with all ESTs]

Unigene Representative Sequence: NM_001711

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331595(uc004fhr.2) ENST00000472615 ENST00000480756 ENST00000431891

ENST00000370204 ENST00000492658

miRNA Products:		OriGene 3'-UTR Clone: BGN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BGN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate BGN:
		hsa-miR-185* hsa-miR-486-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BGN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BGN (see all 7) OriGene shRNA RFP: BGN OriGene siRNA: BGN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BGN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BGN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BGN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: BGN (NM_001711)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BGN
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BGN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BGN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BGN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BGN

Additional cDNA sequence:

AK092954.1 AK093023.1 AK094059.1 AK222484.1 AK223302.1 AK291955.1 AK293268.1 AK293289.1

AK297966.1 AK298756.1 BC002416.2 BC004244.1 BT007323.1 J04599.1 U11686.1

24/53 DOTS entries (see all 53):

DT.86995097 DT.455904 DT.100877240 DT.100877223 DT.100804711 DT.99943230 DT.100877226 DT.97860449

DT.95122348 DT.100031288 DT.97860448 DT.100877237 DT.121287231 DT.85103514 DT.121287285 DT.91657188

DT.121287209 DT.95122339 DT.91761196 DT.100723142 DT.100877242 DT.121287265 DT.121643522 DT.100877233

24/767 AceView cDNA sequences (see all 767):

BP375184 BI041055 R32356 BQ708804 BM856447 BQ882271 BF925736 BM698187

NM_001711 BU736310 CR595264 BP372124 AU141310 CN484687 BQ067023 AW130808

AA554050 AA336870 BQ883638 BQ708510 CR618469 AU142104 AA348703 BP372343

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BGN (see all 11) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	^
SP1:																									-
SP2:					-		-																		-
SP3:					-		-																-		-		-		-
SP4:					-		-						-		-										-
SP5:																									-

ExUns:	12a	·	12b	·	12c	·	12d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BGN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BGN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGTCCCT

About this image

BGN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Tendons & Ligaments

Axial Tendon Primordia

Early Tenocyte Cells

Selective marker (cell-identifying gene)

Tendons & Ligaments

Axial Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Limb Tendon Primordia

Early Tenocyte Cells

Tendons & Ligaments

Limb Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Adipose

Visceral White Adipose

Visceral White Preadipocytes

Adipose

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Connective tissue progenitor cells (Generation of connec...)

See BGN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BGN

SOURCE GeneReport for Unigene cluster: Hs.821

UniProtKB/Swiss-Prot: PGS1_HUMAN, P21810

Tissue specificity: Found in several connective tissues, especially in articular cartilages

SABiosciences Expression via Pathway-Focused PCR Arrays including BGN:

Osteogenesis in human mouse rat

Cardiotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BGN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BGN gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PODN⁶	Uncharacterized protein	20(a)	possible ortholog	8(25317987-25325492)
lizard (Anolis carolinensis)	Reptilia	BGN⁶	--	79(a)	1 ↔ 1	2(87393940-87426153)
African clawed frog (Xenopus laevis)	Amphibia	Xl.939²	Xenopus laevis BGN mRNA for biglycan, complete cds	78.87(n)		AB037269.1
zebrafish (Danio rerio)	Actinopterygii	Dr.16232²	Danio rerio cDNA clone IMAGE6795018, partial cds	77.94(n)		BC054617.1

ENSEMBL Gene Tree for BGN (if available)
TreeFam Gene Tree for BGN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BGN gene

OGN² OPTC² PODN² PODNL1² FMOD² PRELP² KERA² ASPN²

OMD² DCN² EPYC² ECM2² LUM²

8 SIMAP similar genes for BGN using alignment to 3 protein entries: PGS1_HUMAN (see all proteins):

ASPN DCN SLIT2 LRIG3 MST161 PODN

PODNL1 LUM

BGN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143186886^1,2		--	152758401(+)	`AAGCAA/GTGCAG`	2	--	us2k¹ int¹		0	--	--	--	--
rs12012545^1,2	C,F,H,	--	152758525(+)	`gagcaC/Tgtaca`	2	--	us2k¹ int¹		8		NS EA NA WA	418
rs190943824^1,2		--	152758526(+)	`AGCACA/GTACAA`	2	--	int¹ us2k¹		0	--	--	--	--
rs183554354^1,2		--	152758731(+)	`CTCTGC/TGGCCT`	2	--	int¹ us2k¹		0	--	--	--	--
rs185279157^1,2		--	152758767(+)	`CGGAAC/TGTTTC`	2	--	us2k¹ int¹		0	--	--	--	--
rs140226230^1,2		--	152758791(+)	`CTCCAA/CCCAGA`	2	--	int¹ us2k¹		0	--	--	--	--
rs3020975^1,2	C,F,A,	--	152758813(+)	`GCTTCA/GCTGCC`	2	--	us2k¹ int¹		3		NA CSA	5
rs150956347^1,2		--	152758954(+)	`AACCTA/GCCGAA`	2	--	us2k¹ int¹		0	--	--	--	--
rs3761647^1,2	C,F,A,H,	--	152758970(+)	`AGCCAC/TCTCCT`	2	--	us2k¹ int¹		10		EA NS NA	518
rs150131750^1,2		--	152759046(+)	`AGGGTA/TACCAG`	2	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BGN (152760347 - 152775012 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BGN: --
Locus Specific Mutation Databases (LSDB): BGN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BGN

DNA2.0 Custom Variant and Variant Library Synthesis for BGN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BGN for disorders           About GeneDecksing

OMIM gene information: 301870    OMIM disorders: --

20/22 diseases for BGN (see all 22):    About MalaCards

muscular dystrophy ehlers-danlos syndrome exposure keratitis aortic valve stenosis

dyskeratosis congenita pre-eclampsia duchenne muscular dystrophy chondrodysplasia punctata

x inactivation dyskeratosis chondrodysplasia ovarian endometriosis

eclampsia keratitis endometriosis vaginitis

osteoporosis alzheimer's disease osteoarthritis gastric cancer

4 diseases from the University of Copenhagen DISEASES database for BGN:

Osteoarthritis Atherosclerosis Ehlers-Danlos syndrome Exposure keratitis

Human Genome Epidemiology (HuGE) Navigator: BGN (6 documents)

Export disorders for BGN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BGN gene, integrated from 9 sources (see all 98):
(articles sorted by number of sources associating them with BGN)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)^{1, 2} Mallon A.-M....Brown S.D.M. (2000)
Dinucleotide repeat polymorphism at the human biglycan (BGN) locus. (PubMed id 7881444)^{1, 2} Just W.... Vogel W. (1994)
Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. (PubMed id 1612609)^{1, 3} Traupe H....Ropers H.H. (1992)
Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. (PubMed id 1860845)^{1, 2} Fisher L.W.... Young M.F. (1991)
Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. (PubMed id 2590169)^{1, 2} Roughley P.J. and White R.J. (1989)
Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. (PubMed id 2647739)^{1, 2} Fisher L.W.... Young M.F. (1989)
Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)^{1, 2} Fisher L.W.... Termine J.D. (1987)
Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. (PubMed id 12140283)^{1, 9} Chen W.B....Ungefroren H. (2002)
Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling. (PubMed id 12538652)^{1, 9} Ungefroren H....Kalthoff H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 633	HGNC: 1044	AceView: BGN	Ensembl:ENSG00000182492	euGenes: HUgn633
ECgene: BGN	H-InvDB: BGN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BGN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BGN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BGN gene:
Search GeneIP for patents involving BGN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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