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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BGLAP Gene

protein-coding   GIFtS: 58
GCID: GC01P156211

Bone Gamma-Carboxyglutamate (Gla) Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Gamma-Carboxyglutamate (Gla) Protein1 2     BGP2 3
osteocalcin1 2     OC2
Bone Gla Protein2 3     OCN2
Gamma-Carboxyglutamic Acid-Containing Protein2 3     Bone Gamma-Carboxyglutamate (Gla) Protein (Osteocalcin)2

External Ids:    HGNC: 10431   Entrez Gene: 6322   Ensembl: ENSG000002422527   OMIM: 1122605   UniProtKB: P028183   

Export aliases for BGLAP gene to outside databases

Previous GC identifers: GC01P154052 GC01P151948 GC01P152961 GC01P153399 GC01P152995 GC01P153026 GC01P154449 GC01P154478 GC01P127573


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BGLAP Gene: 
BGLAP (bone gamma-carboxyglutamate (gla) protein) is a protein-coding gene. Diseases associated with BGLAP include chondroblastic osteosarcoma, and vitamin d-dependent rickets type ii, and among its related super-pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Transcription Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include hydroxyapatite binding and calcium ion binding.

UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818
Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

Gene Wiki entry for BGLAP (Osteocalcin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BGLAP gene promoter:
         C/EBPbeta   p53   AP-1   ATF-2   YY1   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBGLAP promoter sequence
   Search SABiosciences Chromatin IP Primers for BGLAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BGLAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

BGLAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BGLAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156211:  view genomic region     (about GC identifiers)

Start:
156,211,753 bp from pter      End:
156,213,123 bp from pter
Size:
1,371 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818 (See protein sequence)
Recommended Name: Osteocalcin precursor  
Size: 100 amino acids; 10963 Da
Subcellular location: Secreted
Secondary accessions: Q5TCK6

Explore the universe of human proteins at neXtProt for BGLAP: NX_P02818

Explore proteomics data for BGLAP at MOPED 

Post-translational modifications:

  • UniProtKB: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for
    the binding of calcium
  • View neXtProt modification sites for NX_P02818

  • BGLAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BGLAP Protein Expression
    REFSEQ proteins: NP_954642.1  
    ENSEMBL proteins: 
     ENSP00000357255  

    Human Recombinant Protein Products for BGLAP: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11856645
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--

    BGLAP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000294 GLA_domain
     IPR002384 Osteocalcin/MGP

    Graphical View of Domain Structure for InterPro Entry P02818

    ProtoNet protein and cluster: P02818

    2 Blocks protein domains:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002384 Bone matrix GLA domain signature


    UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818
    Similarity: Belongs to the osteocalcin/matrix Gla protein family
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain


    BGLAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OSTCN_HUMAN, P02818
    Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

         Genatlas biochemistry entry for BGLAP:
    bone gamma-carboxyglutamate protein (osteocalcin),tissue-specific,with a Hind III polymorphism putatively
    influencing bone density and osteoblast growth,regulated by AP1 related protein and CBFA1 transcription factor

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS10486212
    GO:0005509calcium ion binding IEA--
    GO:0008147structural constituent of bone NAS12467198
    GO:0046848hydroxyapatite binding NAS10486212
         
    BGLAP for ontologies           About GeneDecksing


    Animal Models:
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BGLAP:
    hsa-miR-877* hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmidBGLAP 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BGLAP About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97
    2Transcription Role of VDR in regulation of genes involved in osteoporosis
    Transcription Role of VDR in regulation of genes involved in osteoporosis0.80
    3Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Warfarin Pathway, Pharmacodynamics0.67
    4Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    5Notch-mediated HES/HEY network
    Notch-mediated HES/HEY network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for BGLAP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Transcription Role of VDR in regulation of genes involved in osteoporosis


    2 GeneGo (Thomson Reuters) Pathways for BGLAP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    5/6 BioSystems Pathways for BGLAP (see all 6)
        Interleukin-11 Signaling Pathway
    Glucocorticoid receptor regulatory network
    Regulation of retinoblastoma protein
    FGF signaling pathway
    Validated transcriptional targets of AP1 family members Fra1 and Fra2

    1 PharmGKB Pathway for BGLAP
        Warfarin Pathway, Pharmacodynamics


    BGLAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BGLAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for BGLAP (P028183 ENSP000003572554) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078583, ENSP000003420704I2D: score=2 STRING: ENSP00000342070
    CTSDP073393, ENSP000002366714I2D: score=2 STRING: ENSP00000236671
    CTSHP096683, ENSP000002201664I2D: score=2 STRING: ENSP00000220166
    CTSSP257743, ENSP000003579814I2D: score=2 STRING: ENSP00000357981
    GGCXP384353, ENSP000002338384I2D: score=1 STRING: ENSP00000233838
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10865224
    GO:0001503ossification ----
    GO:0001649osteoblast differentiation IEP17023519
    GO:0002076osteoblast development IEA--
    GO:0007155cell adhesion NAS12202187

    BGLAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BGLAP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BGLAP (OSTCN)

    1 HMDB Compound for BGLAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 DrugBank Compounds for BGLAP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phytonadione2-Methyl-3-phythyl-1,4-naphthochinon (see all 12)84-80-0targetagonist11678581 11668761 11374034 10418836 11541904
    Gallium nitrate-- 13494-90-1targetantagonist8366144 8381250
    Gamma-Carboxy-Glutamic Acid-- --target--10592235
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetagonist3060178

    10/117 Novoseek inferred chemical compound relationships for BGLAP gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxypyridinoline 95.2 616 9667483 (4), 10614540 (4), 10219502 (3), 10970981 (3) (see all 99)
    pyridinoline 92.7 353 9667483 (4), 7853745 (4), 10219502 (3), 7572317 (2) (see all 99)
    25-hydroxyvitamin d 89.2 218 20151805 (3), 7747627 (2), 9202793 (2), 20350696 (2) (see all 99)
    hydroxyproline 88 295 18567606 (4), 2232410 (4), 2271160 (3), 11765226 (3) (see all 99)
    vitamin d 87.8 226 1353882 (4), 1484167 (3), 9202793 (2), 11472889 (2) (see all 99)
    calcitriol 86.8 200 12753260 (4), 2035567 (4), 8891532 (4), 12898515 (3) (see all 99)
    procollagen 86.4 179 9541524 (2), 10518820 (2), 10770189 (2), 11063762 (2) (see all 99)
    calcium 83.3 1043 10614547 (6), 11800230 (5), 1991812 (5), 1752232 (5) (see all 99)
    vitamin k1 81.8 84 9541523 (3), 10418836 (3), 9062529 (2), 8844450 (2) (see all 43)
    1,25 dihydroxy vitamin d3 81.7 78 2256116 (4), 2270775 (2), 7747627 (2), 18989673 (2) (see all 63)

    Search CenterWatch for drugs/clinical trials and news about BGLAP / OSTCN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BGLAP gene: 
    NM_199173.4  

    Unigene Cluster for BGLAP:

    Bone gamma-carboxyglutamate (gla) protein
    Hs.654541  [show with all ESTs]
    Unigene Representative Sequence: BF981435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368272(uc001fnt.3) ENST00000471413
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-877* hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmidBGLAP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC113432.1 BC113434.1 X51699.1 X53698.1 

    7 DOTS entries:

    DT.75168058  DT.95227866  DT.101975470  DT.100693257  DT.121447231  DT.449815  DT.91723374 

    24/338 AceView cDNA sequences (see all 338):

    CB241415 X53698 BM698489 AI051654 CF594031 AI084122 BG472335 BQ954413 
    CB122750 CA418691 BM680825 CB144859 T36251 CB852834 BX280657 F05038 
    CA443720 CB242273 BF725575 BQ082830 AI494312 CD369773 BU500984 AK124646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BGLAP expression in normal human tissues (normalized intensities)      BGLAP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGCCCTCA
    BGLAP Expression
    About this image


    BGLAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Bone Marrow Stromal Cells Pelvic Girdle
     
     Bone (Muscoskeletal System)
             Demineralized bone with osteoprogenitor and adult stem cells (TrinityŽ Evolution)

    See BGLAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BGLAP

    SOURCE GeneReport for Unigene cluster: Hs.654541
        SABiosciences Expression via Pathway-Focused PCR Arrays including BGLAP (see all 6): 
              Osteogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BGLAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BGLAP gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    African clawed frog
    (Xenopus laevis)
    Amphibia AF055576.12   -- 81.65(n)    AF055576.1 
            Species with no ortholog for BGLAP

    ENSEMBL Gene Tree for BGLAP (if available)
    TreeFam Gene Tree for BGLAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in BGLAP are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0387434
    ----see VAR_0387432 R Q mis40--------

    HapMap Linkage Disequilibrium report for BGLAP (156211753 - 156213123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BGLAP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509524CNV Insertion20534489
    nsv872470CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BGLAP
    DNA2.0 Custom Variant and Variant Library Synthesis for BGLAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 112260    OMIM disorders: --

    20/208 diseases for BGLAP (see all 208):    About MalaCards
    chondroblastic osteosarcoma    vitamin d-dependent rickets type ii    nontoxic goiter    plagiocephaly
    osteogenesis imperfecta type iii    idiopathic juvenile osteoporosis    kwashiorkor    camurati-engelmann disease
    osteitis fibrosa    osteofibrous dysplasia    monoclonal gammopathy of uncertain significance    schizencephaly
    vitamin k deficiency hemorrhagic disease    aromatase deficiency    ossifying fibroma    spinal cord injury
    saethre-chotzen syndrome    cleidocranial dysplasia    pseudohypoparathyroidism    warfarin sensitivity

    17 diseases from the University of Copenhagen DISEASES database for BGLAP:
    Osteoporosis     Hyperparathyroidism     Vitamin K deficiency hemorrhagic disease     Renal osteodystrophy
    Hypercalcemia     Arthritis     Osteomalacia     Hyperthyroidism
    Hyperostosis     Osteonecrosis     Kidney failure     Diabetes mellitus
    Osteogenesis imperfecta     Osteitis fibrosa     Hypogonadism     Rickets
    Osteopetrosis

    BGLAP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for BGLAP gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis 88.9 106 15108070 (3), 1785325 (3), 15857090 (2), 1559253 (2) (see all 84)
    bone loss 88.8 36 10565254 (2), 18972258 (2), 11138329 (2), 1874931 (1) (see all 31)
    osteopenia 87.3 26 1918789 (3), 8801201 (2), 18810071 (2), 2319404 (1) (see all 20)
    osteoporosis postmenopausal 84.1 30 1796722 (2), 2099937 (2), 2114993 (1), 7583077 (1) (see all 20)
    bone diseases 83.9 37 10359057 (2), 8671970 (2), 9017618 (2), 11125546 (1) (see all 28)
    bone diseases metabolic 78.2 14 2309579 (1), 1959340 (1), 16751699 (1), 2306557 (1) (see all 12)
    renal osteodystrophy 76.9 4 2208702 (1), 2077408 (1), 2082053 (1), 7865545 (1)
    hyperparathyroidism secondary 76.8 19 1843267 (3), 2368448 (2), 15207772 (2), 10771831 (1) (see all 10)
    osteosarcoma 75.9 83 8593206 (3), 9408606 (2), 7576109 (2), 1657256 (2) (see all 65)
    vitamin k deficiency 72.8 11 18578975 (1), 19363777 (1), 19692494 (1), 15320745 (1) (see all 11)

    Genetic Association Database (GAD): BGLAP
    Human Genome Epidemiology (HuGE) Navigator: BGLAP (21 documents)

    Export disorders for BGLAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BGLAP gene, integrated from 9 sources (see all 2618):
    (articles sorted by number of sources associating them with BGLAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women. (PubMed id 15108070)1, 4, 9 Mo X.Y....Deng H.W. (2004)
    2. Osteocalcin gene polymorphisms influence concentratio n of serum osteocalcin and enhance fracture identification. (PubMed id 20200947)1, 4, 9 McGuigan F....Akesson K. (2010)
    3. Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men. (PubMed id 12843190)1, 4, 9 Yamada Y....Shimokata H. (2003)
    4. No evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese women. (PubMed id 17627084)1, 4, 9 Jiang D.K....Deng H.W. (2007)
    5. Relationship of osteocalcin and matrix Gla protein gene polymorphisms to serum osteocalcin levels and bone mineral density in postmenopausal Korean women. (PubMed id 16735944)1, 4, 9 Kim J.G....Moon S.Y. (2006)
    6. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)1, 4, 9 Willing M.C....Levy S.M. (2003)
    7. Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. (PubMed id 11918225)1, 4, 9 Deng H.W....Recker R.R. (2002)
    8. Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans. (PubMed id 20592451)1, 4 Das S.K....Elbein S.C. (2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    10. The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic o f China. (PubMed id 19767102)1, 4 Ba Y....Zhang Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 632 HGNC: 1043 AceView: PMF1andBGLAP Ensembl:ENSG00000242252 euGenes: HUgn632
    ECgene: BGLAP H-InvDB: BGLAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BGLAP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Osteocalcin
    SeattleSNPshttp://pga.gs.washington.edu/data/bglap/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BGLAP gene:
    Search GeneIP for patents involving BGLAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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