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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BGLAP Gene

protein-coding   GIFtS: 59
GCID: GC01P156211

bone gamma-carboxyglutamate (gla) protein
 Explore 228 diseases affiliated with
BGLAP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BGLAP    

Aliases
for BGLAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bone Gamma-Carboxyglutamate (Gla) Protein1 2     OC2
Bone Gla Protein2 3     Bone Gamma-Carboxyglutamate (Gla) Protein (Osteocalcin)2
Gamma-Carboxyglutamic Acid-Containing Protein2 3     Osteocalcin1
BGP2 3     

External Ids:    HGNC: 10431   Entrez Gene: 6322   Ensembl: ENSG000002422527   OMIM: 1122605   UniProtKB: P028183   

Export aliases for BGLAP gene to outside databases

Previous GC identifers: GC01P154052 GC01P151948 GC01P152961 GC01P153399 GC01P152995 GC01P153026 GC01P154449 GC01P154478 GC01P127573


Summaries
for BGLAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818
Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

Gene Wiki entry for BGLAP (Osteocalcin)


Genomic Views
for BGLAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BGLAP gene promoter:
         C/EBPbeta   p53   AP-1   ATF-2   YY1   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BGLAP promoter sequence
   Search SABiosciences Chromatin IP Primers for BGLAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BGLAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

BGLAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BGLAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156211:  view genomic region     (about GC identifiers)

Start:
 156,211,753 bp from pter      End:
 156,213,112 bp from pter
Size:
 1,360 bases      Orientation:
 plus strand

Proteins
for BGLAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818 (See protein sequence)
Recommended Name: Osteocalcin precursor  
Size: 100 amino acids; 10963 Da
Subcellular location: Secreted
Secondary accessions: Q5TCK6

Explore the universe of human proteins at neXtProt for BGLAP: NX_P02818

Post-translational modifications:

  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the
    • binding of calcium1
  • View neXtProt modification sites for NX_P02818

    • BGLAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_954642.1  
    ENSEMBL proteins: 
     ENSP00000357255  

    Human Recombinant Protein Products: 
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    Novus Biologicals BGLAP Proteins
    Novus Biologicals BGLAP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BGLAP

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11856645
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--


    BGLAP for ontologies           About GeneDecksing



    BGLAP Antibody Products: 
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    R&D Systems Antibodies for BGLAP (Osteocalcin)
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    Uscn ELISAs and CLIAs for BGLAP

    Protein Domains /
    Families
    for BGLAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BGLAP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000294 GLA_domain
     IPR002384 Osteocalcin/MGP

    Graphical View of Domain Structure for InterPro Entry P02818

    ProtoNet protein and cluster: P02818

    2 Blocks protein families:
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB002384 Bone matrix GLA domain signature


    UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818
    Similarity: Belongs to the osteocalcin/matrix Gla protein family
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain


    Function
    for BGLAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OSTCN_HUMAN, P02818
    Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

         Genatlas biochemistry entry for BGLAP:
    bone gamma-carboxyglutamate protein (osteocalcin),tissue-specific,with a Hind III polymorphism putatively influencing
    bone density and osteoblast growth,regulated by AP1 related protein and CBFA1 transcription factor

    miRNA
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    hsa-mir-135b (MIRT003596)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BGLAP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BGLAP:
    hsa-miR-877* hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmid: BGLAP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BGLAP
    OriGene shRNA RFP: BGLAP
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BGLAP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BGLAP

    Clone
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    GenScript: all cDNA clones in your preferred vector: BGLAP (NM_199173)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BGLAP 

    Cell Line
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    Search LifeMap BioReagents cell lines for BGLAP

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for BGLAP

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS10486212
    GO:0005509calcium ion binding IEA--
    GO:0008147structural constituent of bone NAS12467198
    GO:0046848hydroxyapatite binding NAS10486212


    BGLAP for ontologies           About GeneDecksing



    Pathways & Interactions
    for BGLAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription_Role of VDR in regulation of genes involved in osteoporosis
    		Transcription_Role of VDR in regulation of genes involved in osteoporosis1.00
    		Transcription Role of VDR in regulation of genes involved in osteoporosis0.80
    2Development_Hedgehog and PTH signaling pathways in bone and cartilage development
    		Development_Hedgehog and PTH signaling pathways in bone and cartilage development1.00
    		Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97
    3Interleukin-11 Signaling Pathway
    		Interleukin-11 Signaling Pathway1.00
    4Validated transcriptional targets of AP1 family members Fra1 and Fra2
    		Validated transcriptional targets of AP1 family members Fra1 and Fra21.00
    5Notch-mediated HES/HEY network
    		Notch-mediated HES/HEY network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for BGLAP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Transcription Role of VDR in regulation of genes involved in osteoporosis


    2 GeneGo (Thomson Reuters) Pathways for BGLAP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    5/6 BioSystems Pathways for BGLAP (see all 6) 
        Interleukin-11 Signaling Pathway
    Glucocorticoid receptor regulatory network
    Regulation of retinoblastoma protein
    Validated transcriptional targets of AP1 family members Fra1 and Fra2
    FGF signaling pathway

    1 PharmGKB Pathway for BGLAP
        Warfarin Pathway, Pharmacodynamics


    BGLAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BGLAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for BGLAP (P028183 ENSP000003572554) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078583, ENSP000003420704I2D: score=2 STRING: ENSP00000342070
    CTSDP073393, ENSP000002366714I2D: score=2 STRING: ENSP00000236671
    CTSHP096683, ENSP000002201664I2D: score=2 STRING: ENSP00000220166
    CTSSP257743, ENSP000003579814I2D: score=2 STRING: ENSP00000357981
    GGCXP384353, ENSP000002338384I2D: score=1 STRING: ENSP00000233838
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS10865224
    GO:0001503ossification ----
    GO:0001649osteoblast differentiation IEP17023519
    GO:0002076osteoblast development IEA--
    GO:0007155cell adhesion NAS12202187


    BGLAP for ontologies           About GeneDecksing



    Drugs & Compounds
    for BGLAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BGLAP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BGLAP

    1 HMDB Compound for BGLAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 DrugBank Compounds for BGLAP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phytonadione2-Methyl-3-phythyl-1,4-naphthochinon (see all 12)84-80-0targetagonist11678581 11668761 11374034 10418836 11541904
    Gallium nitrate-- 13494-90-1targetantagonist8366144 8381250
    Gamma-Carboxy-Glutamic Acid-- --target--10592235
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetagonist3060178

    10/117 Novoseek chemical compound relationships for BGLAP gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxypyridinoline 95.2 616 9667483 (4), 10614540 (4), 10219502 (3), 10970981 (3) (see all 99)
    pyridinoline 92.7 353 9667483 (4), 7853745 (4), 10219502 (3), 7572317 (2) (see all 99)
    25-hydroxyvitamin d 89.2 218 20151805 (3), 7747627 (2), 9202793 (2), 20350696 (2) (see all 99)
    hydroxyproline 88 295 18567606 (4), 2232410 (4), 2271160 (3), 11765226 (3) (see all 99)
    vitamin d 87.8 226 1353882 (4), 1484167 (3), 9202793 (2), 11472889 (2) (see all 99)
    calcitriol 86.8 200 12753260 (4), 2035567 (4), 8891532 (4), 12898515 (3) (see all 99)
    procollagen 86.4 179 9541524 (2), 10518820 (2), 10770189 (2), 11063762 (2) (see all 99)
    calcium 83.3 1043 10614547 (6), 11800230 (5), 1991812 (5), 1752232 (5) (see all 99)
    vitamin k1 81.8 84 9541523 (3), 10418836 (3), 9062529 (2), 8844450 (2) (see all 43)
    1,25 dihydroxy vitamin d3 81.7 78 2256116 (4), 2270775 (2), 7747627 (2), 18989673 (2) (see all 63)

    Search CenterWatch for drugs/clinical trials and news about BGLAP / OSTCN 

    Transcripts
    for BGLAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BGLAP gene: 
    NM_199173.4  

    Unigene Cluster for BGLAP:

    Bone gamma-carboxyglutamate (gla) protein
    Hs.654541  [show with all ESTs]
    Unigene Representative Sequence: BF981435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368272(uc001fnt.3) ENST00000471413

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BGLAP:
    hsa-miR-877* hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmid: BGLAP 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BGLAP

    Additional cDNA sequence: 

    BC113432.1 BC113434.1 X51699.1 X53698.1 

    7 DOTS entries:

    DT.75168058  DT.95227866  DT.101975470  DT.100693257  DT.121447231  DT.449815  DT.91723374 

    24/338 AceView cDNA sequences (see all 338):

    BM046810 BQ223114 BF309795 AI051654 BM048751 CR616631 AI494312 BM128263 
    AK124646 CB144859 BQ082830 CF594031 AI084122 CB852834 AA654391 CB122750 
    BE464816 BG472335 BF725575 BM726081 BU192670 AI313375 BU500984 X51699 

    GeneLoc Exon Structure


    Expression
    for BGLAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BGLAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGCCCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BGLAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Osteoblast-like cells (Osteogenic different...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BGLAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BGLAP

    SOURCE GeneReport for Unigene cluster: Hs.654541
        SABiosciences Expression via Pathway-Focused PCR Arrays including BGLAP (see all 6): 
              Osteogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for BGLAP

    Orthologs
    for BGLAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for BGLAP gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia AF055576.12   -- 81.65(n)    AF055576.1 
            Species with no ortholog for BGLAP

    ENSEMBL Gene Tree for BGLAP (if available)
    TreeFam Gene Tree for BGLAP (if available) 

    Paralogs
    for BGLAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for BGLAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/61 NCBI SNPs in BGLAP are shown (see all 61)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs118084411,2
    		C,F,H--156210008(+) CCCTTG/ATACAA 8 -- ds5001 us2k1 int12Minor allele frequency- A:0.25NA 8
    rs1877883751,2
    		--156210094(+) CATTAC/TGGCCG 8 -- int1 ds5001 us2k10--------
    rs1927538341,2
    		--156210099(+) CGGCCA/GGGTGC 8 -- int1 us2k1 ds50010--------
    rs1405259611,2
    		--156210116(+) TCATGC/TTTGAA 8 -- ds5001 us2k1 int10--------
    rs1386179561,2
    		--156210376(+) ATCTC-/AAAA  
      AAAAAA    AAAAA     		5 -- int1 us2k10--------
    rs112644601,2
    		C,F,A,--156210422(+) CTGTAG/ATCCCA 5 -- int1 us2k15Minor allele frequency- A:0.44NA WA CSA 9
    rs1841781511,2
    		--156210491(+) GAGCCA/GAGATC 5 -- int1 us2k10--------
    rs120905161,2
    		C,F,H,--156210557(+) AACCGC/TGAGCA 5 -- int1 us2k118Minor allele frequency- T:0.26NS EA NA CSA WA 2340
    rs1907822031,2
    		--156210643(+) TCCACC/TAGAGG 5 -- int1 us2k10--------
    rs1924594331,2
    		--156210651(+) AGGGGG/TAAAGG 5 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for BGLAP (156211753 - 156213112 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BGLAP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BGLAP
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    Disorders / Diseases
    for BGLAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BGLAP for disorders           About GeneDecksing

    OMIM gene information: 112260    OMIM disorders: --

    20/228 diseases for BGLAP (see all 228):    About MalaCards
    ossification of posterior longitudinal ligament of spine    camurati-engelmann disease    vitamin d-dependent rickets type ii    saethre-chotzen syndrome
    pseudohypoparathyroidism type ib    monoclonal gammopathy of uncertain significance    osteitis fibrosa    osteogenesis imperfecta
    vitamin k deficiency hemorrhagic disease    nontoxic goiter    osteogenesis imperfecta type iii    spinal cord injury
    x-linked hypophosphatemia    pigmented villonodular synovitis    chondroblastic osteosarcoma    high blood pressure
    villonodular synovitis    growth hormone deficiency    end stage renal failure    hypersensitivity reaction type ii disease

    17 diseases from the University of Copenhagen DISEASES database for BGLAP:
    Osteoporosis     Hyperparathyroidism     Renal osteodystrophy     Vitamin K deficiency hemorrhagic disease
    Osteomalacia     Hypercalcemia     Arthritis     Hyperthyroidism
    Hyperostosis     Osteonecrosis     Kidney failure     Osteitis fibrosa
    Diabetes mellitus     Rickets     Hypogonadism     Osteogenesis imperfecta
    Osteopetrosis

    10/93 Novoseek disease relationships for BGLAP gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis 88.9 106 15108070 (3), 1785325 (3), 15857090 (2), 1559253 (2) (see all 84)
    bone loss 88.8 36 10565254 (2), 18972258 (2), 11138329 (2), 1874931 (1) (see all 31)
    osteopenia 87.3 26 1918789 (3), 8801201 (2), 18810071 (2), 2319404 (1) (see all 20)
    osteoporosis postmenopausal 84.1 30 1796722 (2), 2099937 (2), 2114993 (1), 7583077 (1) (see all 20)
    bone diseases 83.9 37 10359057 (2), 8671970 (2), 9017618 (2), 11125546 (1) (see all 28)
    bone diseases metabolic 78.2 14 2309579 (1), 1959340 (1), 16751699 (1), 2306557 (1) (see all 12)
    renal osteodystrophy 76.9 4 2208702 (1), 2077408 (1), 2082053 (1), 7865545 (1)
    hyperparathyroidism secondary 76.8 19 1843267 (3), 2368448 (2), 15207772 (2), 10771831 (1) (see all 10)
    osteosarcoma 75.9 83 8593206 (3), 9408606 (2), 7576109 (2), 1657256 (2) (see all 65)
    vitamin k deficiency 72.8 11 18578975 (1), 19363777 (1), 19692494 (1), 15320745 (1) (see all 11)

    Genetic Association Database (GAD): BGLAP
    Human Genome Epidemiology (HuGE) Navigator: BGLAP (21 documents)

    Export disorders for BGLAP gene to outside databases

    Publications
    for BGLAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BGLAP gene, integrated from 9 sources (see all 2608):
    (articles sorted by number of sources associating them with BGLAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women. (PubMed id 15108070)1, 4, 9 Mo X.Y....Deng H.W. (2004)
    2. Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men. (PubMed id 12843190)1, 4, 9 Yamada Y....Shimokata H. (2003)
    3. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)1, 4, 9 Willing M.C....Levy S.M. (2003)
    4. Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. (PubMed id 11918225)1, 4, 9 Deng H.W....Recker R.R. (2002)
    5. Osteocalcin gene HindIII C/T polymorphism is a biomarker for prostate cancer and responsiveness to hormone therapy. (PubMed id 12565780)1, 4 Wu H.C....Tsai F.J. (2003)
    6. Osteocalcin gene Hind III polymorphism is not correlated with calcium oxalate stone disease. (PubMed id 11396736)1, 4 Chen W.C....Tsai F.J. (2001)
    7. Relation of polymorphism in the promotor region for the human osteocalcin gene to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. (PubMed id 11574953)1, 4 Chen H.Y....Tsai C.H. (2001)
    8. Osteocalcin gene polymorphism is related to bone density in healthy adolescent females. (PubMed id 11199188)1, 4 Gustavsson A....Lorentzon M. (2000)
    9. The cDNA and derived amino acid sequences of human and bovine bone Gla protein. (PubMed id 2336375)1, 2 Kiefer M.C.... Barr P.J. (1990)
    10. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. (PubMed id 2394711)1, 3 Cancela L....Price P.A. (1990)

    External Searches for BGLAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing BGLAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 632 HGNC: 1043 AceView: PMF1andBGLAP Ensembl:ENSG00000242252 euGenes: HUgn632
    ECgene: BGLAP H-InvDB: BGLAP

    Other Databases showing BGLAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BGLAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BGLAP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Osteocalcin
    SeattleSNPshttp://pga.gs.washington.edu/data/bglap/

    Intellectual Property
    for BGLAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BGLAP gene:
    Search GeneIP for patents involving BGLAP

    GeneCards and IP:
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