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Aliases for BGLAP Gene

Aliases for BGLAP Gene

  • Bone Gamma-Carboxyglutamate (Gla) Protein 2 3
  • Gamma-Carboxyglutamic Acid-Containing Protein 3 4
  • Bone Gla Protein 3 4
  • Osteocalcin 2 3
  • BGP 3 4
  • Bone Gamma-Carboxyglutamate (Gla) Protein (Osteocalcin) 3
  • OCN 3
  • OC 3

External Ids for BGLAP Gene

Summaries for BGLAP Gene

GeneCards Summary for BGLAP Gene

BGLAP (Bone Gamma-Carboxyglutamate (Gla) Protein) is a Protein Coding gene. Diseases associated with BGLAP include nontoxic goiter and kwashiorkor. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include calcium ion binding and hydroxyapatite binding.

UniProtKB/Swiss-Prot for BGLAP Gene

  • Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

Gene Wiki entry for BGLAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BGLAP Gene

Genomics for BGLAP Gene

Genomic Location for BGLAP Gene

Start:
156,241,962 bp from pter
End:
156,243,332 bp from pter
Size:
1,371 bases
Orientation:
Plus strand

Genomic View for BGLAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BGLAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BGLAP Gene

Regulatory Elements for BGLAP Gene

Proteins for BGLAP Gene

  • Protein details for BGLAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02818-OSTCN_HUMAN
    Recommended name:
    Osteocalcin
    Protein Accession:
    P02818
    Secondary Accessions:
    • Q5TCK6

    Protein attributes for BGLAP Gene

    Size:
    100 amino acids
    Molecular mass:
    10963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BGLAP Gene

Proteomics data for BGLAP Gene at MOPED

Post-translational modifications for BGLAP Gene

  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Other Protein References for BGLAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BGLAP Gene

Domains for BGLAP Gene

UniProtKB/Swiss-Prot:

OSTCN_HUMAN
Domain:
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.:
    • P02818
Family:
  • Belongs to the osteocalcin/matrix Gla protein family.:
    • P02818
genes like me logo Genes that share domains with BGLAP: view

No data available for Gene Families for BGLAP Gene

Function for BGLAP Gene

Molecular function for BGLAP Gene

GENATLAS Biochemistry: bone gamma-carboxyglutamate protein (osteocalcin),tissue-specific,with a Hind III polymorphism putatively influencing bone density and osteoblast growth,regulated by AP1 related protein and CBFA1 transcription factor
UniProtKB/Swiss-Prot Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

Gene Ontology (GO) - Molecular Function for BGLAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 10486212
GO:0005509 calcium ion binding IEA --
GO:0008147 structural constituent of bone NAS 12467198
GO:0046848 hydroxyapatite binding NAS 10486212
genes like me logo Genes that share ontologies with BGLAP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BGLAP Gene

Localization for BGLAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BGLAP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BGLAP Gene COMPARTMENTS Subcellular localization image for BGLAP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for BGLAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IDA 11856645
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with BGLAP: view

Pathways for BGLAP Gene

genes like me logo Genes that share pathways with BGLAP: view

Gene Ontology (GO) - Biological Process for BGLAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10865224
GO:0001503 ossification --
GO:0001649 osteoblast differentiation IEP 17023519
GO:0002076 osteoblast development IEA --
GO:0007155 cell adhesion NAS 12202187
genes like me logo Genes that share ontologies with BGLAP: view

Compounds for BGLAP Gene

(1) HMDB Compounds for BGLAP Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Drugbank Compounds for BGLAP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Gallium nitrate
13494-90-1 target antagonist
Gamma-Carboxy-Glutamic Acid
target
Menadione
  • 2-Methyl-1,4-Naphthalenedione
58-27-5 target agonist
Phytonadione
  • 2-Methyl-3-phythyl-1,4-naphthochinon
84-80-0 target agonist

(117) Novoseek inferred chemical compound relationships for BGLAP Gene

Compound -log(P) Hits PubMed IDs
deoxypyridinoline 95.2 157
pyridinoline 92.7 128
25-hydroxyvitamin d 89.2 111
hydroxyproline 88 132
vitamin d 87.8 122
genes like me logo Genes that share compounds with BGLAP: view

Transcripts for BGLAP Gene

mRNA/cDNA for BGLAP Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(338) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BGLAP Gene

Bone gamma-carboxyglutamate (gla) protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BGLAP Gene

No ASD Table

Relevant External Links for BGLAP Gene

GeneLoc Exon Structure for
BGLAP
ECgene alternative splicing isoforms for
BGLAP

Expression for BGLAP Gene

mRNA expression in normal human tissues for BGLAP Gene

SOURCE GeneReport for Unigene cluster for BGLAP Gene Hs.654541

genes like me logo Genes that share expressions with BGLAP: view

Orthologs for BGLAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for BGLAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BGLAP 36
  • 99.67 (n)
  • 99 (a)
BGLAP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BGLAP 36
  • 89.02 (n)
  • 87.8 (a)
BGLAP 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BGLAP 36
  • 83.74 (n)
  • 82.93 (a)
BGLAP 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bglap 37
  • 63 (a)
OneToMany
Bglap2 36
  • 75 (n)
  • 68.48 (a)
Bglap2 37
  • 65 (a)
OneToMany
Bglap3 37
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia BGLAP 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bglap 36
  • 77.55 (n)
  • 72.45 (a)
Species with no ortholog for BGLAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BGLAP Gene

ENSEMBL:
Gene Tree for BGLAP (if available)
TreeFam:
Gene Tree for BGLAP (if available)

Paralogs for BGLAP Gene

No data available for Paralogs for BGLAP Gene

Variants for BGLAP Gene

Sequence variations from dbSNP and Humsavar for BGLAP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_038743 -

Structural Variations from Database of Genomic Variants (DGV) for BGLAP Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV Insertion 20534489
nsv872470 CNV Loss 21882294

Relevant External Links for BGLAP Gene

HapMap Linkage Disequilibrium report
BGLAP
Human Gene Mutation Database (HGMD)
BGLAP

Disorders for BGLAP Gene

(93) Novoseek inferred disease relationships for BGLAP Gene

Disease -log(P) Hits PubMed IDs
osteoporosis 88.9 92
bone loss 88.8 34
osteopenia 87.3 24
osteoporosis postmenopausal 84.1 22
bone diseases 83.9 31

Relevant External Links for BGLAP

Genetic Association Database (GAD)
BGLAP
Human Genome Epidemiology (HuGE) Navigator
BGLAP
genes like me logo Genes that share disorders with BGLAP: view

No data available for UniProtKB/Swiss-Prot for BGLAP Gene

Publications for BGLAP Gene

  1. Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. (PMID: 11918225) Deng H.W. … Recker R.R. (J. Bone Miner. Res. 2002) 3 23 49
  2. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PMID: 12879219) Willing M.C. … Levy S.M. (Osteoporos Int 2003) 3 23 49
  3. Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women. (PMID: 15108070) Mo X.Y. … Deng H.W. (J. Bone Miner. Metab. 2004) 3 23 49
  4. No evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese women. (PMID: 17627084) Jiang D.K. … Deng H.W. (J Musculoskelet Neuronal Interact 2007) 3 23 49
  5. Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men. (PMID: 12843190) Yamada Y. … Shimokata H. (J. Clin. Endocrinol. Metab. 2003) 3 23 49

Products for BGLAP Gene

Sources for BGLAP Gene

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