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Aliases for BEX5 Gene

Aliases for BEX5 Gene

  • Brain Expressed, X-Linked 5 2 3
  • NGFRAP1L1 3 4 6
  • Nerve Growth Factor Receptor-Associated Protein 2 3 4
  • Brain-Expressed X-Linked Protein 5 3 4
  • NGFRAP1-Like Protein 1 3 4
  • BEX Family Member 5 2 3
  • NGFRAP1-Like 1 2 3
  • Protein BEX5 3
  • NADE2 4

External Ids for BEX5 Gene

Previous HGNC Symbols for BEX5 Gene


Previous GeneCards Identifiers for BEX5 Gene

  • GC0XM101296
  • GC0XM101408
  • GC0XM091216

Summaries for BEX5 Gene

GeneCards Summary for BEX5 Gene

BEX5 (Brain Expressed, X-Linked 5) is a Protein Coding gene. An important paralog of this gene is NGFRAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX5 Gene

Genomics for BEX5 Gene

Regulatory Elements for BEX5 Gene

Genomic Location for BEX5 Gene

102,153,707 bp from pter
102,156,057 bp from pter
2,351 bases
Minus strand

Genomic View for BEX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BEX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX5 Gene

Proteins for BEX5 Gene

  • Protein details for BEX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BEX5
    Protein Accession:
    Secondary Accessions:
    • Q569J0
    • Q56A74

    Protein attributes for BEX5 Gene

    111 amino acids
    Molecular mass:
    12602 Da
    Quaternary structure:
    No Data Available
    • The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene

neXtProt entry for BEX5 Gene

Proteomics data for BEX5 Gene at MOPED

Post-translational modifications for BEX5 Gene

Other Protein References for BEX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX5 Gene

Domains for BEX5 Gene

Protein Domains for BEX5 Gene


Suggested Antigen Peptide Sequences for BEX5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5H9J7
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX5: view

No data available for Gene Families for BEX5 Gene

Function for BEX5 Gene

Gene Ontology (GO) - Molecular Function for BEX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEX5: view

Animal Model Products

CRISPR Products

miRNA for BEX5 Gene

miRTarBase miRNAs that target BEX5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BEX5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BEX5 Gene

Localization for BEX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX5 Gene


Subcellular locations from

Jensen Localization Image for BEX5 Gene COMPARTMENTS Subcellular localization image for BEX5 gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BEX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BEX5: view

Pathways for BEX5 Gene

SuperPathways for BEX5 Gene

No Data Available

Interacting Proteins for BEX5 Gene

Gene Ontology (GO) - Biological Process for BEX5 Gene


No data available for Pathways by source for BEX5 Gene

Transcripts for BEX5 Gene

mRNA/cDNA for BEX5 Gene

Unigene Clusters for BEX5 Gene

Brain expressed, X-linked 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BEX5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEX5 Gene

No ASD Table

Relevant External Links for BEX5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEX5 Gene

mRNA expression in normal human tissues for BEX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEX5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.3), Brain - Anterior cingulate cortex (BA24) (5.3), Brain - Cortex (4.8), Brain - Hypothalamus (4.4), and Brain - Amygdala (4.2).

Protein differential expression in normal tissues for BEX5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BEX5 Gene

SOURCE GeneReport for Unigene cluster for BEX5 Gene Hs.47209

genes like me logo Genes that share expressions with BEX5: view

Expression partners for BEX5 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BEX5 Gene

Orthologs for BEX5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BEX5 35
  • 85.59 (n)
  • 76.58 (a)
BEX5 36
  • 74 (a)
(Canis familiaris)
Mammalia BEX5 35
  • 88.59 (n)
  • 79.28 (a)
BEX5 36
  • 70 (a)
(Pan troglodytes)
Mammalia BEX5 35
  • 99.1 (n)
  • 99.1 (a)
BEX5 36
  • 99 (a)
Species with no ortholog for BEX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX5 Gene

Gene Tree for BEX5 (if available)
Gene Tree for BEX5 (if available)

Paralogs for BEX5 Gene

Paralogs for BEX5 Gene

Selected SIMAP similar genes for BEX5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX5: view

Variants for BEX5 Gene

Sequence variations from dbSNP and Humsavar for BEX5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs929009 -- 102,155,805(-) CGGGT(C/G)TAGGA intron-variant, upstream-variant-2KB
rs4898327 -- 102,155,226(+) GGACG(A/G)TGAGT intron-variant
rs5903198 -- 102,155,850(+) CAGCG(-/C)CCACC intron-variant, upstream-variant-2KB
rs5945039 -- 102,153,594(+) TCTGG(G/T)TTTCA downstream-variant-500B
rs5945040 -- 102,156,926(+) CTGGG(C/T)GATAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BEX5 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV Complex 16826518

Relevant External Links for BEX5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEX5 Gene

Disorders for BEX5 Gene

No disorders were found for BEX5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BEX5 Gene

Publications for BEX5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 3 4
  4. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  5. Adaptive evolution and frequent gene conversion in the brain expressed X-linked gene family in mammals. (PMID: 18236150) Zhang L. (Biochem. Genet. 2008) 3

Products for BEX5 Gene

Sources for BEX5 Gene

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