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Aliases for BEX5 Gene

Aliases for BEX5 Gene

  • Brain Expressed X-Linked 5 2 3 5
  • Nerve Growth Factor Receptor-Associated Protein 2 3 4
  • Brain-Expressed X-Linked Protein 5 3 4
  • NGFRAP1-Like Protein 1 3 4
  • BEX Family Member 5 2 3
  • NGFRAP1-Like 1 2 3
  • NGFRAP1L1 3 4
  • Protein BEX5 3
  • NADE2 4

External Ids for BEX5 Gene

Previous HGNC Symbols for BEX5 Gene

  • NGFRAP1L1

Previous GeneCards Identifiers for BEX5 Gene

  • GC0XM101296
  • GC0XM101408
  • GC0XM091216

Summaries for BEX5 Gene

GeneCards Summary for BEX5 Gene

BEX5 (Brain Expressed X-Linked 5) is a Protein Coding gene. An important paralog of this gene is BEX3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX5 Gene

Genomics for BEX5 Gene

Regulatory Elements for BEX5 Gene

Enhancers for BEX5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF101930 0.9 ENCODE 14.9 +224.4 224381 2.1 ATF1 CBX3 ZNF48 YY1 EGR1 CBX5 CREM EGR2 ZNF362 SP3 BEX5 TCEAL6 ZMAT1 RNU6-345P
GH0XF101685 0.4 ENCODE 29.1 +469.6 469643 0.9 PRDM10 BEX5 LOC100420247 GC0XP101692
GH0XF102141 0.5 Ensembl 18.4 +14.1 14057 0.4 ZNF121 POLR2A PRDM10 CHD7 BEX5 TCEAL6 LOC105373299
GH0XF101622 0.9 ENCODE 9.9 +532.7 532707 2.6 ATF1 ZNF133 SIN3A ZNF766 ZNF366 CREM EGR2 SP3 USF2 RAD51 BEX5 ARMCX6 ARMCX3 ARMCX3-AS1
GH0XF101799 0.9 Ensembl ENCODE 7.9 +356.4 356371 0.6 CTCF MAZ ZNF654 PKNOX1 TRIM22 RAD21 ZBTB40 ZNF518A GABPA PBX2 ARMCX2 ARMCX6 ARMCX3 ARMCX3-AS1 BEX5 GK4P NXF5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BEX5 on UCSC Golden Path with GeneCards custom track

Promoters for BEX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001918078 557 1800 CTCF RFX1 MTA1 POLR2A ZNF384 CREM

Genomic Location for BEX5 Gene

Chromosome:
X
Start:
102,153,707 bp from pter
End:
102,156,057 bp from pter
Size:
2,351 bases
Orientation:
Minus strand

Genomic View for BEX5 Gene

Genes around BEX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX5 Gene

Proteins for BEX5 Gene

  • Protein details for BEX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9J7-BEX5_HUMAN
    Recommended name:
    Protein BEX5
    Protein Accession:
    Q5H9J7
    Secondary Accessions:
    • Q569J0
    • Q56A74

    Protein attributes for BEX5 Gene

    Size:
    111 amino acids
    Molecular mass:
    12602 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

neXtProt entry for BEX5 Gene

Post-translational modifications for BEX5 Gene

Other Protein References for BEX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX5 Gene

Domains & Families for BEX5 Gene

Gene Families for BEX5 Gene

Protein Domains for BEX5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H9J7

UniProtKB/Swiss-Prot:

BEX5_HUMAN :
  • Belongs to the BEX family.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX5: view

Function for BEX5 Gene

Gene Ontology (GO) - Molecular Function for BEX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEX5: view

Phenotypes for BEX5 Gene

genes like me logo Genes that share phenotypes with BEX5: view

Animal Model Products

miRNA for BEX5 Gene

miRTarBase miRNAs that target BEX5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX5 Gene

Localization for BEX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEX5 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for BEX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BEX5: view

Pathways & Interactions for BEX5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEX5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BEX5 Gene

Transcripts for BEX5 Gene

mRNA/cDNA for BEX5 Gene

Unigene Clusters for BEX5 Gene

Brain expressed, X-linked 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEX5 Gene

No ASD Table

Relevant External Links for BEX5 Gene

GeneLoc Exon Structure for
BEX5
ECgene alternative splicing isoforms for
BEX5

Expression for BEX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BEX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEX5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Cortex (x4.8), Brain - Hypothalamus (x4.4), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for BEX5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BEX5 Gene



Protein tissue co-expression partners for BEX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BEX5 Gene:

BEX5

SOURCE GeneReport for Unigene cluster for BEX5 Gene:

Hs.47209
genes like me logo Genes that share expression patterns with BEX5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for BEX5 Gene

Orthologs for BEX5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEX5 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia BEX5 34 35
  • 88.59 (n)
cow
(Bos Taurus)
Mammalia BEX5 34 35
  • 85.59 (n)
Species where no ortholog for BEX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX5 Gene

ENSEMBL:
Gene Tree for BEX5 (if available)
TreeFam:
Gene Tree for BEX5 (if available)

Paralogs for BEX5 Gene

Paralogs for BEX5 Gene

(4) SIMAP similar genes for BEX5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX5: view

Variants for BEX5 Gene

Sequence variations from dbSNP and Humsavar for BEX5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10522301 -- 102,153,633(+) TATAT(-/ATATATATATATATAT)TTCAT downstream-variant-500B
rs111619192 -- 102,154,833(+) AATTA(C/G)CAGGA intron-variant
rs112281042 -- 102,157,003(+) AAAGG(-/AA/AAGAAGAA)AAGAA upstream-variant-2KB
rs112361831 -- 102,154,219(+) TCTGC(A/G/T)CTGGG reference, missense
rs113712663 -- 102,153,992(+) AATGC(A/C/G)CAGAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BEX5 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV loss 16826518

Variation tolerance for BEX5 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BEX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEX5 Gene

Disorders for BEX5 Gene

Relevant External Links for BEX5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEX5

No disorders were found for BEX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX5 Gene

Publications for BEX5 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64

Products for BEX5 Gene

Sources for BEX5 Gene

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