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Aliases for BEX4 Gene

Aliases for BEX4 Gene

  • Brain Expressed, X-Linked 4 2 3
  • Nerve Growth Factor Receptor-Associated Protein 3 3 4
  • Brain Expressed X-Linked-Like 1 2 3
  • BEX Family Member 4 2 3
  • BEX1-Like Protein 1 3 4
  • BEXL1 3 4
  • Brain-Expressed X-Linked Protein 4 4
  • Protein BEX4 3
  • NADE3 4

External Ids for BEX4 Gene

Previous Symbols for BEX4 Gene

  • BEXL1

Summaries for BEX4 Gene

Entrez Gene Summary for BEX4 Gene

  • This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for BEX4 Gene

BEX4 (Brain Expressed, X-Linked 4) is a Protein Coding gene. An important paralog of this gene is NGFRAP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX4 Gene

Genomics for BEX4 Gene

Genomic Location for BEX4 Gene

Start:
103,215,092 bp from pter
End:
103,217,246 bp from pter
Size:
2,155 bases
Orientation:
Plus strand

Genomic View for BEX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BEX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX4 Gene

Regulatory Elements for BEX4 Gene

Proteins for BEX4 Gene

  • Protein details for BEX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWD9-BEX4_HUMAN
    Recommended name:
    Protein BEX4
    Protein Accession:
    Q9NWD9
    Secondary Accessions:

    Protein attributes for BEX4 Gene

    Size:
    120 amino acids
    Molecular mass:
    14067 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BEX4 Gene

Proteomics data for BEX4 Gene at MOPED

Post-translational modifications for BEX4 Gene

Other Protein References for BEX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX4 Gene

Domains for BEX4 Gene

Protein Domains for BEX4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BEX4_HUMAN
Family:
  • Belongs to the BEX family.:
    • Q9NWD9
genes like me logo Genes that share domains with BEX4: view

No data available for Gene Families for BEX4 Gene

Function for BEX4 Gene

Phenotypes for BEX4 Gene

GenomeRNAi human phenotypes for BEX4:
genes like me logo Genes that share phenotypes with BEX4: view

miRNA for BEX4 Gene

miRTarBase miRNAs that target BEX4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for BEX4 Gene

Localization for BEX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX4 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEX4 Gene COMPARTMENTS Subcellular localization image for BEX4 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BEX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BEX4: view

Pathways for BEX4 Gene

SuperPathways for BEX4 Gene

No Data Available

Interacting Proteins for BEX4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361776%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000361776 Q9NWD9-BEX4_HUMAN for BEX4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BEX4 Gene

None

No data available for Pathways by source for BEX4 Gene

Transcripts for BEX4 Gene

mRNA/cDNA for BEX4 Gene

Unigene Clusters for BEX4 Gene

Brain expressed, X-linked 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEX4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for BEX4 Gene

GeneLoc Exon Structure for
BEX4
ECgene alternative splicing isoforms for
BEX4

Expression for BEX4 Gene

mRNA expression in normal human tissues for BEX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for BEX4 Gene Hs.184736

genes like me logo Genes that share expressions with BEX4: view

Orthologs for BEX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEX4 36
  • 100 (n)
  • 100 (a)
BEX4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BEX4 36
  • 80.56 (n)
  • 65.83 (a)
MGC140151 37
  • 66 (a)
OneToMany
MGC140151 37
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BEX4 37
  • 75 (a)
OneToMany
BEX4 37
  • 70 (a)
OneToMany
LOC100688441 36
  • 83.9 (n)
  • 74.58 (a)
mouse
(Mus musculus)
Mammalia Bex4 36
  • 75.99 (n)
  • 60.17 (a)
Bex4 16
Bex4 37
  • 58 (a)
OneToMany
Bex6 37
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bex4 36
  • 77.68 (n)
  • 61.86 (a)
Species with no ortholog for BEX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX4 Gene

ENSEMBL:
Gene Tree for BEX4 (if available)
TreeFam:
Gene Tree for BEX4 (if available)

Paralogs for BEX4 Gene

Paralogs for BEX4 Gene

Selected SIMAP similar genes for BEX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX4: view

Variants for BEX4 Gene

Sequence variations from dbSNP and Humsavar for BEX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14661 -- 103,217,107(-) ACACA(A/C)CAATG utr-variant-3-prime
rs1064784 -- 103,216,603(+) TTTGG(G/T)GTTTA utr-variant-3-prime
rs2273065 -- 103,215,886(+) CACAC(C/G)CCATC intron-variant
rs3179998 -- 103,216,300(+) GGAAA(C/T)ATCAG synonymous-codon, reference
rs3180253 -- 103,216,425(+) AATCA(A/G/T)GAGAA reference, missense

Relevant External Links for BEX4 Gene

HapMap Linkage Disequilibrium report
BEX4
Locus Specific Mutation Databases (LSDB)
BEX4

No data available for Structural Variations from Database of Genomic Variants (DGV) for BEX4 Gene

Disorders for BEX4 Gene

No disorders were found for BEX4 Gene.

No data available for UniProtKB/Swiss-Prot for BEX4 Gene

Publications for BEX4 Gene

  1. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 2 3 4
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BEX4 Gene

Sources for BEX4 Gene

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