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Aliases for BEX4 Gene

Aliases for BEX4 Gene

  • Brain Expressed X-Linked 4 2 3 5
  • Nerve Growth Factor Receptor-Associated Protein 3 3 4
  • Brain Expressed X-Linked-Like 1 2 3
  • BEX Family Member 4 2 3
  • BEX1-Like Protein 1 3 4
  • BEXL1 3 4
  • Brain-Expressed X-Linked Protein 4 4
  • Protein BEX4 3
  • NADE3 4

External Ids for BEX4 Gene

Previous HGNC Symbols for BEX4 Gene

  • BEXL1

Previous GeneCards Identifiers for BEX4 Gene

  • GC0XP102357
  • GC0XP102470
  • GC0XP092133

Summaries for BEX4 Gene

Entrez Gene Summary for BEX4 Gene

  • This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for BEX4 Gene

BEX4 (Brain Expressed X-Linked 4) is a Protein Coding gene. An important paralog of this gene is BEX3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX4 Gene

Genomics for BEX4 Gene

Regulatory Elements for BEX4 Gene

Enhancers for BEX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BEX4 on UCSC Golden Path with GeneCards custom track

Promoters for BEX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BEX4 Gene

103,215,092 bp from pter
103,217,246 bp from pter
2,155 bases
Plus strand

Genomic View for BEX4 Gene

Genes around BEX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX4 Gene

Proteins for BEX4 Gene

  • Protein details for BEX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BEX4
    Protein Accession:

    Protein attributes for BEX4 Gene

    120 amino acids
    Molecular mass:
    14067 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BEX4 Gene

Post-translational modifications for BEX4 Gene

Other Protein References for BEX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX4 Gene

Domains & Families for BEX4 Gene

Gene Families for BEX4 Gene

Protein Domains for BEX4 Gene


Suggested Antigen Peptide Sequences for BEX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BEX family.
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX4: view

Function for BEX4 Gene

genes like me logo Genes that share phenotypes with BEX4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX4 Gene

Localization for BEX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX4 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for BEX4 Gene COMPARTMENTS Subcellular localization image for BEX4 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for BEX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with BEX4: view

Pathways & Interactions for BEX4 Gene

SuperPathways for BEX4 Gene

No Data Available

Interacting Proteins for BEX4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361776 Q9NWD9-BEX4_HUMAN for BEX4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BEX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for BEX4 Gene

Drugs & Compounds for BEX4 Gene

No Compound Related Data Available

Transcripts for BEX4 Gene

mRNA/cDNA for BEX4 Gene

Unigene Clusters for BEX4 Gene

Brain expressed, X-linked 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEX4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: -
SP2: -
SP3: - -

Relevant External Links for BEX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEX4 Gene

mRNA expression in normal human tissues for BEX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of BEX4 Gene:


SOURCE GeneReport for Unigene cluster for BEX4 Gene:

genes like me logo Genes that share expression patterns with BEX4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BEX4 Gene

Orthologs for BEX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BEX4 34
  • 80.56 (n)
  • 65.83 (a)
MGC140151 35
  • 66 (a)
MGC140151 35
  • 66 (a)
(Canis familiaris)
Mammalia LOC100688441 34
  • 83.9 (n)
  • 74.58 (a)
BEX4 35
  • 75 (a)
BEX4 35
  • 70 (a)
(Mus musculus)
Mammalia Bex4 34
  • 75.99 (n)
  • 60.17 (a)
Bex4 16
Bex4 35
  • 58 (a)
Bex6 35
  • 49 (a)
(Pan troglodytes)
Mammalia BEX4 34
  • 100 (n)
  • 100 (a)
BEX4 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Bex4 34
  • 77.68 (n)
  • 61.86 (a)
Species where no ortholog for BEX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX4 Gene

Gene Tree for BEX4 (if available)
Gene Tree for BEX4 (if available)

Paralogs for BEX4 Gene

Paralogs for BEX4 Gene

(4) SIMAP similar genes for BEX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX4: view

Variants for BEX4 Gene

Sequence variations from dbSNP and Humsavar for BEX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs748010235 -- 103,215,091(+) CCCCA(A/C)GTGAC upstream-variant-2KB
rs748344741 -- 103,217,220(+) TAATT(-/AAAA)AAGAA downstream-variant-500B
rs748703006 -- 103,214,689(+) GACAT(C/T)TTGCT upstream-variant-2KB
rs748708849 -- 103,216,231(+) GAGCA(A/G)GCCCC reference, synonymous-codon
rs749218752 -- 103,215,736(+) AATCC(-/G)GAGGA intron-variant, utr-variant-5-prime

Variation tolerance for BEX4 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEX4 Gene

Disorders for BEX4 Gene

Relevant External Links for BEX4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BEX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX4 Gene

Publications for BEX4 Gene

  1. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 2 3 4 65
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 65
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3 65

Products for BEX4 Gene

Sources for BEX4 Gene

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