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Aliases for BEX3 Gene

Aliases for BEX3 Gene

  • Brain Expressed X-Linked 3 2 3
  • Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 2 3 5
  • NGFRAP1 3 4 5
  • Ovarian Granulosa Cell 13.0 KDa Protein HGR74 3 4
  • P75NTR-Associated Cell Death Executor 3 4
  • Brain-Expressed X-Linked Protein 3 3 4
  • DXS6984E 3 4
  • NADE 3 4
  • Nerve Growth Factor Receptor-Associated Protein 1 4
  • HGR74 3
  • Bex 3

External Ids for BEX3 Gene

Previous HGNC Symbols for BEX3 Gene

  • NGFRAP1

Summaries for BEX3 Gene

GeneCards Summary for BEX3 Gene

BEX3 (Brain Expressed X-Linked 3) is a Protein Coding gene. Among its related pathways are Apoptosis - multiple species and p75 NTR receptor-mediated signalling. An important paralog of this gene is BEX5.

UniProtKB/Swiss-Prot for BEX3 Gene

  • May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.

Gene Wiki entry for BEX3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX3 Gene

Genomics for BEX3 Gene

Regulatory Elements for BEX3 Gene

Enhancers for BEX3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BEX3 on UCSC Golden Path with GeneCards custom track

Promoters for BEX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BEX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEX3 Gene

Chromosome:
X
Start:
103,376,323 bp from pter
End:
103,378,164 bp from pter
Size:
1,842 bases
Orientation:
Plus strand

Genomic View for BEX3 Gene

Genes around BEX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX3 Gene

Proteins for BEX3 Gene

  • Protein details for BEX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00994-BEX3_HUMAN
    Recommended name:
    Protein BEX3
    Protein Accession:
    Q00994
    Secondary Accessions:
    • B2RD17
    • D3DXA3
    • Q5JQT4
    • Q5JQT5

    Protein attributes for BEX3 Gene

    Size:
    111 amino acids
    Molecular mass:
    12959 Da
    Quaternary structure:
    • Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR.
    Miscellaneous:
    • Binds transition metals.

    Three dimensional structures from OCA and Proteopedia for BEX3 Gene

    Alternative splice isoforms for BEX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BEX3 Gene

Proteomics data for BEX3 Gene at MOPED

Post-translational modifications for BEX3 Gene

Other Protein References for BEX3 Gene

Antibody Products

  • Abcam antibodies for NADE

No data available for DME Specific Peptides for BEX3 Gene

Domains & Families for BEX3 Gene

Gene Families for BEX3 Gene

Protein Domains for BEX3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00994

UniProtKB/Swiss-Prot:

BEX3_HUMAN :
  • The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.
  • Belongs to the BEX family.
Domain:
  • The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX3: view

Function for BEX3 Gene

Molecular function for BEX3 Gene

UniProtKB/Swiss-Prot Function:
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.

Gene Ontology (GO) - Molecular Function for BEX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005163 nerve growth factor receptor binding IEA --
genes like me logo Genes that share ontologies with BEX3: view
genes like me logo Genes that share phenotypes with BEX3: view

Animal Model Products

miRNA for BEX3 Gene

miRTarBase miRNAs that target BEX3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX3 Gene

Localization for BEX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX3 Gene

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BEX3 Gene

Pathways & Interactions for BEX3 Gene

genes like me logo Genes that share pathways with BEX3: view

Pathways by source for BEX3 Gene

Gene Ontology (GO) - Biological Process for BEX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA --
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0097190 apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with BEX3: view

No data available for SIGNOR curated interactions for BEX3 Gene

Drugs & Compounds for BEX3 Gene

No Compound Related Data Available

Transcripts for BEX3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for BEX3 Gene

No ASD Table

Relevant External Links for BEX3 Gene

GeneLoc Exon Structure for
BEX3
ECgene alternative splicing isoforms for
BEX3

Expression for BEX3 Gene

mRNA Expression by UniProt/SwissProt for BEX3 Gene

Q00994-BEX3_HUMAN
Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BEX3 Gene

Orthologs for BEX3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NGFRAP1 35
  • 93.39 (n)
  • 94.59 (a)
NGFRAP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGFRAP1 35
  • 93.99 (n)
  • 98.2 (a)
NGFRAP1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngfrap1 35
  • 88.89 (n)
  • 92.79 (a)
Ngfrap1 16
Ngfrap1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NGFRAP1 35
  • 100 (n)
  • 100 (a)
NGFRAP1 36
  • 100 (a)
OneToOne
Species with no ortholog for BEX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX3 Gene

ENSEMBL:
Gene Tree for BEX3 (if available)
TreeFam:
Gene Tree for BEX3 (if available)

Paralogs for BEX3 Gene

Paralogs for BEX3 Gene

genes like me logo Genes that share paralogs with BEX3: view

Variants for BEX3 Gene

Sequence variations from dbSNP and Humsavar for BEX3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747974052 -- 103,377,428(+) TCAGT(C/T)TCTCT intron-variant, utr-variant-5-prime
rs748624710 -- 103,375,170(+) CTTTT(C/T)TTTTT upstream-variant-2KB
rs748651587 -- 103,374,897(+) AAGAT(C/G)TGACG upstream-variant-2KB
rs748764160 -- 103,377,474(+) ACCAG(-/A)AAAAA intron-variant, reference, frameshift-variant, utr-variant-5-prime
rs749429348 -- 103,376,204(+) GCCAA(A/G)GCCTG upstream-variant-2KB

Variation tolerance for BEX3 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BEX3 Gene

Disorders for BEX3 Gene

Relevant External Links for BEX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEX3

No disorders were found for BEX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX3 Gene

Publications for BEX3 Gene

  1. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. (PMID: 10764727) Mukai J. … Sato T.-A. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  3. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 3 23
  4. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. (PMID: 15178455) Yoon K. … Lee S.Y. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. (PMID: 12739005) Tong X. … Koeffler H.P. (Int. J. Oncol. 2003) 3 23

Products for BEX3 Gene

Sources for BEX3 Gene

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