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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BEX2 Gene

protein-coding   GIFtS: 51
GCID: GC0XM102564

brain expressed X-linked 2
 Explore 8 diseases affiliated with
BEX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BEX2    

Aliases
for BEX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Brain Expressed X-Linked 21 2
DJ79P11.11 2
Brain-Expressed X-Linked Protein 22 3
HBex21
BEX12
Protein BEX22

External Ids:    HGNC: 309331   Entrez Gene: 847072   Ensembl: ENSG000001331347   OMIM: 3006915   UniProtKB: Q9BXY83   

Export aliases for BEX2 gene to outside databases

Previous GC identifers: GC0XM101337 GC0XM102370 GC0XM102450 GC0XM092227


Summaries
for BEX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BEX2:
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription
factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This
gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene
product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of
tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: BEX2_HUMAN, Q9BXY8
Function: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells
against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which
involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members
BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the
regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity

Gene Wiki entry for BEX2


Genomic Views
for BEX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BEX2 gene promoter:
         Nkx3-1   ER-alpha   Max1   Nkx3-1 v1   XBP-1   LCR-F1   Nkx3-1 v2   Max   c-Myc   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BEX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BEX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

BEX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEX2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102564:  view genomic region     (about GC identifiers)

Start:
 102,564,274 bp from pter      End:
 102,565,974 bp from pter
Size:
 1,701 bases      Orientation:
 minus strand

Proteins
for BEX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BEX2_HUMAN, Q9BXY8 (See protein sequence)
Recommended Name: Protein BEX2  
Size: 128 amino acids; 15321 Da
Subunit: Interacts with OMP (By similarity). Interacts with LMO2, possibly leading to regulate the transcriptional
activity of a DNA-binding complex containing LMO2
Subcellular location: Cytoplasm (By similarity). Nucleus
Caution: Was named BEX1 by some authors
Sequence caution: Sequence=CAI43072.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R574 D3DXA2 Q5JVV9

Explore the universe of human proteins at neXtProt for BEX2: NX_Q9BXY8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BXY8

    • BEX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001161871.1  NP_001161872.1  NP_001161873.1  NP_116010.1  

    ENSEMBL proteins: 
     ENSP00000361762   ENSP00000361759   ENSP00000394915   ENSP00000442521  

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    Uscn Proteins for BEX2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    BEX2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BEX2

    Protein Domains /
    Families
    for BEX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BEX2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021156 TF_A-like/BEX-like
     IPR007623 BEX

    Graphical View of Domain Structure for InterPro Entry Q9BXY8

    ProtoNet protein and cluster: Q9BXY8

    UniProtKB/Swiss-Prot: BEX2_HUMAN, Q9BXY8
    Similarity: Belongs to the BEX family


    Function
    for BEX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BEX2_HUMAN, Q9BXY8
    Function: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells
    against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which
    involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members
    BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the
    regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BEX2:
    hsa-miR-338-5p hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmid: BEX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    2 GenomeRNAi human phenotypes for BEX2:
     Decreased viability with pacli  Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for BEX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BEX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/10 Interacting proteins for BEX2 (Q9BXY83 ENSP000003617594) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    LMO2P257913, ENSP000002578184I2D: score=1 STRING: ENSP00000257818
    KRTAP4-12Q9BQ663, ENSP000003775824I2D: score=4 STRING: ENSP00000377582
    MAGEA11P433643, ENSP000003473584I2D: score=4 STRING: ENSP00000347358
    OMPP478743I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0042981regulation of apoptotic process IDA19711341
    GO:0051726regulation of cell cycle IDA19711341


    BEX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BEX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BEX2
    Search CenterWatch for drugs/clinical trials and news about BEX2 

    Transcripts
    for BEX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BEX2 gene (4 alternative transcripts): 
    NM_001168399.1  NM_001168400.1  NM_001168401.1  NM_032621.3  

    Unigene Cluster for BEX2:

    Brain expressed X-linked 2
    Hs.398989  [show with all ESTs]
    Unigene Representative Sequence: BC050651
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372677(uc022cbo.1 uc004ekb.3) ENST00000372674 ENST00000449185
    ENST00000536889(uc022cbn.1 uc004eka.3)

    miRNA
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    hsa-miR-338-5p hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmid: BEX2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF251053.1 AK312085.1 AY833560.1 BC015522.1 BC050651.1 

    9 DOTS entries:

    DT.100817092  DT.85104881  DT.100817090  DT.121305833  DT.99977054  DT.92462691  DT.92462661  DT.121305822 
    DT.121305827 

    24/155 AceView cDNA sequences (see all 155):

    BM695670 CR607680 AA970215 CA842193 BM823696 BM698168 CA841897 AI826617 
    CA844335 NM_032621 CR606275 BU786390 BM311912 BC015522 BE645101 CA849017 
    AA953177 BU784660 AA464180 BI791488 AI569624 BU782667 AI745669 AI141583 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BEX2    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d
    SP1:                                -                                 
    SP2:                          -     -                                 
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for BEX2

    Expression
    for BEX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BEX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGATGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BEX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See BEX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BEX2

    SOURCE GeneReport for Unigene cluster: Hs.398989

    UniProtKB/Swiss-Prot: BEX2_HUMAN, Q9BXY8
    Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe.
    Widely expressed in breast cancer cell lines

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    In Situ
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    Orthologs
    for BEX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for BEX2 (if available)
    TreeFam Gene Tree for BEX2 (if available) 

    Paralogs
    for BEX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BEX2 gene
    BEX12  BEX52  NGFRAP12  BEX42  
    4 SIMAP similar genes for BEX2 using alignment to 2 protein entries:     BEX2_HUMAN (see all proteins):
    BEX1    BEX4    BEX5    NGFRAP1

    BEX2 for paralogs           About GeneDecksing



    Genomic Variants
    for BEX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/66 NCBI SNPs in BEX2 are shown (see all 66)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs169843161,2
    		C,F,H,--102563978(+) AGAGAA/GCCCAG 4 -- ds500117Minor allele frequency- G:0.24NA NS EA WA 2020
    rs1461908091,2
    		--102563979(+) GAGAAC/TCCAGA 4 -- ds50010--------
    rs1916340461,2
    		--102564104(+) AATTAA/TGGGTA 4 -- ds50010--------
    rs720096751,2
    		C,--102564169(+) GTGTG-/TGTGTAT 4 -- ds50010--------
    rs19744571,2
    		C,F--102564180(-) ATATAC/TACACA 4 -- ds50013Minor allele frequency- T:0.42NA EA 252
    rs1845240671,2
    		--102564318(+) TGAGCA/GTCTTT 4 -- ut310--------
    rs1891431891,2
    		--102564349(+) TCCTGC/TTGACA 4 -- ut310--------
    rs2001440101,2
    		--102564517(+) CAGGAA/TTCAGG 4 -- ut310--------
    rs75571,2
    		C,F,A,H,--102564583(-) ATAGTC/TTGCGG 8 L syn117Minor allele frequency- T:0.28MN NS EA WA NA CSA 5361
    rs1507155091,2
    		C--102564607(+) TTCCCT/CCAGCT 8 /R /G mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for BEX2 (102564274 - 102565974 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BEX2
         2 CNVs: 96861 96862
    Locus Specific Mutation Databases (LSDB): BEX2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEX2
    DNA2.0 Custom Variant and Variant Library Synthesis for BEX2

    Disorders / Diseases
    for BEX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BEX2 for disorders           About GeneDecksing

    OMIM gene information: 300691    OMIM disorders: --

    8 diseases for BEX2:    About MalaCards
    breast cancer    ischemic optic neuropathy    acute myeloid leukemia    myeloid leukemia
    malignant glioma    oligodendroglioma    neuropathy    leukemia


    Export disorders for BEX2 gene to outside databases

    Publications
    for BEX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BEX2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with BEX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer. (PubMed id 19711341)1, 2 Naderi A.... Bennett I.C. (2009)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Characterization of the Bex gene family in humans, mice, and rats. (PubMed id 15958283)1, 2 Alvarez E.... Freed C.R. (2005)
    4. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PubMed id 16314316)1, 2 Han C.... Peng X. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (PubMed id 16818640)1, 9 Foltz G....Madan A. (2006)
    8. [BEX2 regulates cell cycle through the interaction wit h INI1/hSNF5]. (PubMed id 22698742)1 Han Q.Y....Han C.Y. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. A feedback loop between BEX2 and ErbB2 mediated by c- Jun signaling in breast cancer. (PubMed id 21384344)1 Naderi A....Francis G.D. (2012)

    External Searches for BEX2 gene

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    Genome Databases showing BEX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84707 HGNC: 30933 AceView: BEX2 Ensembl:ENSG00000133134 euGenes: HUgn84707
    ECgene: BEX2 H-InvDB: BEX2

    Other Databases showing BEX2 gene

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    Specialized Databases showing BEX2 gene

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    PharmGKB entry for BEX2 Pharmacogenomics, SNPs, Pathways

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