Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BEX2 Gene

Aliases for BEX2 Gene

  • Brain Expressed X-Linked 2 2 3 5
  • Brain-Expressed X-Linked Protein 2 3 4
  • HBEX2 3 4
  • DJ79P11.1 3
  • BEX1 3

External Ids for BEX2 Gene

Previous GeneCards Identifiers for BEX2 Gene

  • GC0XM101337
  • GC0XM102370
  • GC0XM102450
  • GC0XM102564
  • GC0XM092227

Summaries for BEX2 Gene

Entrez Gene Summary for BEX2 Gene

  • This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for BEX2 Gene

BEX2 (Brain Expressed X-Linked 2) is a Protein Coding gene. Diseases associated with BEX2 include breast cancer. Among its related pathways are p75(NTR)-mediated signaling. An important paralog of this gene is BEX1.

UniProtKB/Swiss-Prot for BEX2 Gene

  • Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.

Gene Wiki entry for BEX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX2 Gene

Genomics for BEX2 Gene

Regulatory Elements for BEX2 Gene

Promoters for BEX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BEX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEX2 Gene

Chromosome:
X
Start:
103,309,346 bp from pter
End:
103,311,046 bp from pter
Size:
1,701 bases
Orientation:
Minus strand

Genomic View for BEX2 Gene

Genes around BEX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX2 Gene

Proteins for BEX2 Gene

  • Protein details for BEX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXY8-BEX2_HUMAN
    Recommended name:
    Protein BEX2
    Protein Accession:
    Q9BXY8
    Secondary Accessions:
    • B2R574
    • D3DXA2
    • F5H7H5
    • Q5JVV9

    Protein attributes for BEX2 Gene

    Size:
    128 amino acids
    Molecular mass:
    15321 Da
    Quaternary structure:
    • Interacts with OMP (By similarity). Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2.
    SequenceCaution:
    • Sequence=CAI43072.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BEX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BEX2 Gene

Proteomics data for BEX2 Gene at MOPED

Post-translational modifications for BEX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEX2 Gene

No data available for DME Specific Peptides for BEX2 Gene

Domains & Families for BEX2 Gene

Gene Families for BEX2 Gene

Protein Domains for BEX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXY8

UniProtKB/Swiss-Prot:

BEX2_HUMAN :
  • Belongs to the BEX family.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX2: view

Function for BEX2 Gene

Molecular function for BEX2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
genes like me logo Genes that share phenotypes with BEX2: view

Animal Model Products

miRNA for BEX2 Gene

miRTarBase miRNAs that target BEX2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX2 Gene

Localization for BEX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEX2 Gene COMPARTMENTS Subcellular localization image for BEX2 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for BEX2 Gene

Pathways & Interactions for BEX2 Gene

SuperPathways for BEX2 Gene

Superpath Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with BEX2: view

Pathways by source for BEX2 Gene

1 BioSystems pathway for BEX2 Gene

Gene Ontology (GO) - Biological Process for BEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IDA 19711341
genes like me logo Genes that share ontologies with BEX2: view

No data available for SIGNOR curated interactions for BEX2 Gene

Drugs & Compounds for BEX2 Gene

No Compound Related Data Available

Transcripts for BEX2 Gene

Unigene Clusters for BEX2 Gene

Brain expressed X-linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for BEX2 Gene

GeneLoc Exon Structure for
BEX2
ECgene alternative splicing isoforms for
BEX2

Expression for BEX2 Gene

mRNA expression in normal human tissues for BEX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for BEX2 Gene Hs.398989

mRNA Expression by UniProt/SwissProt for BEX2 Gene

Q9BXY8-BEX2_HUMAN
Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
genes like me logo Genes that share expression patterns with BEX2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BEX2 Gene

Orthologs for BEX2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BEX2 35
  • 87.24 (n)
  • 78.12 (a)
BEX2 36
  • 80 (a)
ManyToMany
BEX2 36
  • 78 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100688940 35
  • 86.2 (n)
  • 78.91 (a)
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia BEX2 35
  • 99.17 (n)
  • 98.75 (a)
BEX2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bex1 36
  • 67 (a)
ManyToMany
Bex2 36
  • 71 (a)
ManyToMany
Species with no ortholog for BEX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX2 Gene

ENSEMBL:
Gene Tree for BEX2 (if available)
TreeFam:
Gene Tree for BEX2 (if available)

Paralogs for BEX2 Gene

Paralogs for BEX2 Gene

(4) SIMAP similar genes for BEX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX2: view

Variants for BEX2 Gene

Sequence variations from dbSNP and Humsavar for BEX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs7557 -- 103,309,655(-) ATAGT(C/T)TGCGG reference, synonymous-codon
rs9781 -- 103,309,712(+) CTCCC(A/C)AATCC reference, missense
rs1128200 -- 103,310,414(-) GTGTT(C/G)CGGCG reference, missense, utr-variant-5-prime
rs1128202 -- 103,310,373(-) AGACT(A/G)CAAGG reference, missense, utr-variant-5-prime
rs1045050 -- 103,310,408(-) CGGCG(A/G)CGCAC reference, missense, utr-variant-5-prime

Variation tolerance for BEX2 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEX2 Gene

HapMap Linkage Disequilibrium report
BEX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEX2 Gene

Disorders for BEX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BEX2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search BEX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BEX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEX2
genes like me logo Genes that share disorders with BEX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BEX2 Gene

Publications for BEX2 Gene

  1. BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer. (PMID: 19711341) Naderi A. … Bennett I.C. (Int. J. Cancer 2010) 3 4 67
  2. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (PMID: 16818640) Foltz G. … Madan A. (Cancer Res. 2006) 3 23
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  4. I9-catenin is involved in Bex2 down-regulation induced glioma cell invasion/migration inhibition. (PMID: 25490384) Nie E. … Yu R. (Biochem. Biophys. Res. Commun. 2015) 3
  5. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3

Products for BEX2 Gene

Sources for BEX2 Gene

Back to Top

Content