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Aliases for BEX2 Gene

Aliases for BEX2 Gene

  • Brain Expressed X-Linked 2 2 3 5
  • Brain-Expressed X-Linked Protein 2 3 4
  • HBEX2 3 4
  • Protein BEX2 3
  • DJ79P11.1 3
  • BEX1 3

External Ids for BEX2 Gene

Previous GeneCards Identifiers for BEX2 Gene

  • GC0XM101337
  • GC0XM102370
  • GC0XM102450
  • GC0XM102564
  • GC0XM092227

Summaries for BEX2 Gene

Entrez Gene Summary for BEX2 Gene

  • This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for BEX2 Gene

BEX2 (Brain Expressed X-Linked 2) is a Protein Coding gene. Diseases associated with BEX2 include Breast Cancer. An important paralog of this gene is BEX1.

UniProtKB/Swiss-Prot for BEX2 Gene

  • Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.

Gene Wiki entry for BEX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX2 Gene

Genomics for BEX2 Gene

Regulatory Elements for BEX2 Gene

Enhancers for BEX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG103310 0.9 ENCODE 18.9 +0.0 27 1.2 HDAC1 ATF1 SIN3A GLIS2 EGR1 ZNF366 CREM EGR2 SP3 SMAD5 BEX4 BEX2 BEX1 GPRASP2 TCEAL5
GH0XG103729 1.4 FANTOM5 Ensembl ENCODE 7 -419.9 -419917 2.7 ZBTB21 ZIC2 YY1 HIC1 POLR2A ZBTB48 ZNF366 ZNF600 KLF8 MAFK BEX2 GLRA4 PLP1
GH0XG103655 1.1 Ensembl ENCODE 7.2 -346.6 -346640 4.2 TBP FOXA2 BRCA1 RFX5 GATA2 ZNF366 RCOR1 FOS EGR2 CEBPB BEX4 MORF4L2-AS1 MORF4L2 TCEAL3 ZCCHC18 TCEAL1 TCEAL3-AS1 BHLHB9 PLP1 FAM199X
GH0XG103716 0.7 Ensembl ENCODE 9.8 -406.3 -406271 1.7 ZNF707 JUND BEX2 BEX4 TMSB15B TMEM31 GLRA4
GH0XG103637 0.8 Ensembl ENCODE 7 -327.5 -327482 2.2 RFX1 RFX3 MYNN FOS ZIC2 TCEAL3 TCEAL4 PLP1 BEX4 BEX2 LOC105373302 LOC100130176
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BEX2 on UCSC Golden Path with GeneCards custom track

Promoters for BEX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247693 246 1200 HDAC1 ATF1 EGR1 ZNF366 CREM EGR2 SP3 USF2 ZEB2 REST

Genomic Location for BEX2 Gene

Chromosome:
X
Start:
103,309,346 bp from pter
End:
103,311,046 bp from pter
Size:
1,701 bases
Orientation:
Minus strand

Genomic View for BEX2 Gene

Genes around BEX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX2 Gene

Proteins for BEX2 Gene

  • Protein details for BEX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXY8-BEX2_HUMAN
    Recommended name:
    Protein BEX2
    Protein Accession:
    Q9BXY8
    Secondary Accessions:
    • B2R574
    • D3DXA2
    • F5H7H5
    • Q5JVV9

    Protein attributes for BEX2 Gene

    Size:
    128 amino acids
    Molecular mass:
    15321 Da
    Quaternary structure:
    • Interacts with OMP (By similarity). Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2.
    SequenceCaution:
    • Sequence=CAI43072.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BEX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BEX2 Gene

Post-translational modifications for BEX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEX2 Gene

Antibody Products

  • Abcam antibodies for BEX2

No data available for DME Specific Peptides for BEX2 Gene

Domains & Families for BEX2 Gene

Gene Families for BEX2 Gene

Protein Domains for BEX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXY8

UniProtKB/Swiss-Prot:

BEX2_HUMAN :
  • Belongs to the BEX family.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX2: view

Function for BEX2 Gene

Molecular function for BEX2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.

Gene Ontology (GO) - Molecular Function for BEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEX2: view
genes like me logo Genes that share phenotypes with BEX2: view

Animal Model Products

CRISPR Products

miRNA for BEX2 Gene

miRTarBase miRNAs that target BEX2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX2 Gene

Localization for BEX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEX2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for BEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BEX2: view

Pathways & Interactions for BEX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0042981 regulation of apoptotic process IDA 19711341
GO:0051726 regulation of cell cycle IDA 19711341
genes like me logo Genes that share ontologies with BEX2: view

No data available for Pathways by source and SIGNOR curated interactions for BEX2 Gene

Transcripts for BEX2 Gene

Unigene Clusters for BEX2 Gene

Brain expressed X-linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for BEX2 Gene

GeneLoc Exon Structure for
BEX2
ECgene alternative splicing isoforms for
BEX2

Expression for BEX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of BEX2 Gene:

BEX2

SOURCE GeneReport for Unigene cluster for BEX2 Gene:

Hs.398989

mRNA Expression by UniProt/SwissProt for BEX2 Gene:

Q9BXY8-BEX2_HUMAN
Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.

Evidence on tissue expression from TISSUES for BEX2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with BEX2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEX2 Gene

Orthologs for BEX2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEX2 34 35
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia BEX2 34 35 35
  • 87.24 (n)
dog
(Canis familiaris)
Mammalia LOC100688940 34
  • 86.2 (n)
-- 35
  • 79 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Bex2 35
  • 71 (a)
ManyToMany
Bex1 35
  • 67 (a)
ManyToMany
Species where no ortholog for BEX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX2 Gene

ENSEMBL:
Gene Tree for BEX2 (if available)
TreeFam:
Gene Tree for BEX2 (if available)

Paralogs for BEX2 Gene

Paralogs for BEX2 Gene

(4) SIMAP similar genes for BEX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX2: view

Variants for BEX2 Gene

Sequence variations from dbSNP and Humsavar for BEX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs751303856 Benign 103,310,417(+) CGCAA(C/T)ACTTG reference, missense, utr-variant-5-prime
rs1000016198 -- 103,310,599(+) GCATC(A/G)AGAAG intron-variant, utr-variant-5-prime
rs1003392636 -- 103,310,956(+) CGAGC(C/G)ACGGC upstream-variant-2KB, utr-variant-5-prime
rs1006008883 -- 103,312,841(+) CCCAA(C/T)AGAAT upstream-variant-2KB
rs1007187201 -- 103,311,480(+) ATTTT(C/T)ACTTG upstream-variant-2KB

Variation tolerance for BEX2 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BEX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEX2 Gene

Disorders for BEX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BEX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search BEX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BEX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEX2
genes like me logo Genes that share disorders with BEX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BEX2 Gene

Publications for BEX2 Gene

  1. BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer. (PMID: 19711341) Naderi A. … Bennett I.C. (Int. J. Cancer 2010) 3 4 64
  2. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (PMID: 16818640) Foltz G. … Madan A. (Cancer Res. 2006) 3 22 64
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 3 4 64

Products for BEX2 Gene

Sources for BEX2 Gene

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