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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BEX1 Gene

protein-coding   GIFtS: 52
GCID: GC0XM102317

Brain Expressed, X-Linked 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Brain Expressed, X-Linked 11 2     HGR74-h2
Brain-Expressed X-Linked Protein 12 3     Ovarian Granulosa Cell 13.0 KDa Protein HGR742
BEX22     Protein BEX12
HBEX22     

External Ids:    HGNC: 10361   Entrez Gene: 558592   Ensembl: ENSG000001331697   OMIM: 3006905   UniProtKB: Q9HBH73   

Export aliases for BEX1 gene to outside databases

Previous GC identifers: GC0XM097619 GC0XM099226 GC0XM100350 GC0XM101089 GC0XM102123 GC0XM102204 GC0XM091981


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BEX1 Gene: 
BEX1 (brain expressed, X-linked 1) is a protein-coding gene. Diseases associated with BEX1 include ischemic optic neuropathy, and acute myeloid leukemia. GO annotations related to this gene include RNA polymerase II activating transcription factor binding. An important paralog of this gene is BEX2.

UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and
neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as
a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator
of receptor signaling, coordinating biological responses to external signals with internal cellular states (By
similarity)

Gene Wiki entry for BEX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BEX1 gene promoter:
         TBP   AML1a   Pax-2   Pax-2a   LCR-F1   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBEX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BEX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1|Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

BEX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEX1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102317:  view genomic region     (about GC identifiers)

Start:
102,317,579 bp from pter      End:
102,319,168 bp from pter
Size:
1,590 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7 (See protein sequence)
Recommended Name: Protein BEX1  
Size: 125 amino acids; 14860 Da
Subunit: Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus (By similarity)
Caution: Was named BEX2 by some authors
Secondary accessions: A0AVN1 A8K4J3 Q9NZ33

Explore the universe of human proteins at neXtProt for BEX1: NX_Q9HBH7

Explore proteomics data for BEX1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity)
  • UniProtKB: Ubiquitinated. Degraded by the proteasome (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBH7

  • BEX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BEX1 Protein Expression
    REFSEQ proteins: NP_060946.3  
    ENSEMBL proteins: 
     ENSP00000361813  

    Human Recombinant Protein Products for BEX1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for BEX1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IDA16314316
    GO:0005737cytoplasm IEA--

    BEX1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for BEX1 
    Cloud-Clone Corp. CLIAs for BEX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR007623 BEX

    Graphical View of Domain Structure for InterPro Entry Q9HBH7

    ProtoNet protein and cluster: Q9HBH7

    UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
    Similarity: Belongs to the BEX family


    BEX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BEX1_HUMAN, Q9HBH7
    Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and
    neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as
    a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator
    of receptor signaling, coordinating biological responses to external signals with internal cellular states (By
    similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IPI16314316
         
    BEX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BEX1:
     Upregulation of NF-kappaB path 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bex1):
     homeostasis/metabolism  muscle 

    BEX1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BEX1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BEX1 
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    miRNA
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    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BEX1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling


    1 BioSystems Pathway for BEX1
        p75(NTR)-mediated signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BEX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for BEX1 (Q9HBH72, 3 ENSP000003618134) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8256921 I2D: score=2 
    NGFRP081383, ENSP000001722294I2D: score=1 STRING: ENSP00000172229
    OMPP478743I2D: score=3 
    NGFENSP000003585254STRING: ENSP00000358525
    RIPK2ENSP000002207514STRING: ENSP00000220751
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA16314316
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IDA16314316

    BEX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BEX1

    Search CenterWatch for drugs/clinical trials and news about BEX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BEX1 gene: 
    NM_018476.3  

    Unigene Cluster for BEX1:

    Brain expressed, X-linked 1
    Hs.334370  [show with all ESTs]
    Unigene Representative Sequence: BM804232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372728(uc004ejt.1)
    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of BEX1 
    Primer
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    OriGene qPCR primer pairs and template standards for BEX1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEX1
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    Additional mRNA sequence: 

    AF183416.1 AF220189.1 AF237783.1 AK290958.1 AY833561.1 BC018615.2 BC105298.1 BC126427.1 
    BC126429.1 

    7 DOTS entries:

    DT.121305858  DT.121305599  DT.100817093  DT.449419  DT.121305745  DT.95112426  DT.95255948 

    24/181 AceView cDNA sequences (see all 181):

    BU950387 CA848357 BM272042 CD108814 CD108600 AA364196 BF971303 BU950090 
    BM510819 CA946842 BQ269428 BG656300 BG655001 BU948036 CA866502 BI791514 
    CB177549 CA866770 W68339 BG820179 BI712924 BM719125 AI884903 AW087092 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BEX1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for BEX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BEX1 expression in normal human tissues (normalized intensities)      BEX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BEX1 Expression
    About this image


    BEX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Hypothalamus
             Human Cerebellar Astrocytes   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Mature Rod Bipolar Cells Inner Nuclear Layer
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
             Human Calvarial Osteoblasts (HCO)   
     
     Epithelium
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Fibroblast (Uncategorized)    fully expand to see all 3 entries
             Human Gingival Fibroblasts (HGF)   

    See BEX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BEX1

    SOURCE GeneReport for Unigene cluster: Hs.334370

    UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
    Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal
    lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone
    marrow. Highly expressed in acute myeloid leukemia

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for BEX1 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bex15 brain expressed gene 1   --   X (57.40 cM) 136213972 


    ENSEMBL Gene Tree for BEX1 (if available)
    TreeFam Gene Tree for BEX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BEX1 gene
    BEX22  
    4 SIMAP similar genes for BEX1 using alignment to 1 protein entry:     BEX1_HUMAN:
    BEX2    BEX4    BEX5    NGFRAP1

    BEX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 SNPs in BEX1 are shown (see all 129)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735239821,2
    C--91985364(+) GCCATG/ATTAGC 1 -- us2k12Minor allele frequency- A:0.33WA CSA 3
    rs1422247681,2
    --91985424(+) AAACAA/GCTTTA 1 -- us2k10--------
    rs1849454091,2
    --102317148(+) ACTTAC/TAAATG 1 -- ds50010--------
    rs59876651,2
    C,H--102317235(+) CACAAA/CAGACA 1 -- ds50016Minor allele frequency- C:0.00WA NA CSA 8
    rs1901955241,2
    C--102317720(+) CCCACA/GTAAAC 1 -- ut310--------
    rs10452031,2
    F--102317740(-) TAAACC/G/TTTTAC 2 -- ut313MN NA 188
    rs1998515191,2
    --102317787(+) CAGGGG/TTCTGT 1 -- ut310--------
    rs10451751,2
    C--102317797(-) TATTAC/G/TGGAAA 2 -- ut31 ese32MN NA 186
    rs1483082041,2
    C--102317887(+) TGCCCG/ACAGAC 2 /R /W mis11Minor allele frequency- A:0.00NA 4552
    rs1414640741,2
    C--102317952(+) CAATCC/TTTTCC 2 K R mis11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for BEX1 (102317579 - 102319168 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BEX1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BEX1
    DNA2.0 Custom Variant and Variant Library Synthesis for BEX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300690    OMIM disorders: --

    7 diseases for BEX1:    About MalaCards
    ischemic optic neuropathy    acute myeloid leukemia    malignant glioma    neuropathy
    myeloid leukemia    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for BEX1:
    Ischemic optic neuropathy

    BEX1 for disorders           About GeneDecksing


    Export disorders for BEX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BEX1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with BEX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. (PubMed id 11989783)1, 2, 9 Yang Q.-S.... Mao Y.-M. (2002)
    2. Expression of BEX1 in acute myeloid leukemia with MLL rearrangements. (PubMed id 15920485)1, 2 Quentmeier H....Drexler H.G. (2005)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. Characterization of the Bex gene family in humans, mice, and rats. (PubMed id 15958283)1, 2 Alvarez E.... Freed C.R. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PubMed id 16314316)1, 9 Han C.... Peng X. (2005)
    7. Epigenetic regulation of the X-linked tumour suppresso rs BEX1 and LDOC1 in oral squamous cell carcinoma. (PubMed id 23362108)1 Lee C.H....Chang J.Y. (2013)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55859 HGNC: 1036 AceView: BEX1 Ensembl:ENSG00000133169 euGenes: HUgn55859
    ECgene: BEX1 H-InvDB: BEX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BEX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BEX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BEX1 gene:
    Search GeneIP for patents involving BEX1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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