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Aliases for BEX1 Gene

Aliases for BEX1 Gene

  • Brain Expressed, X-Linked 1 2 3
  • Brain-Expressed X-Linked Protein 1 3 4
  • Ovarian Granulosa Cell 13.0 KDa Protein HGR74 3
  • Protein BEX1 3
  • HGR74-H 3
  • HBex2 3
  • BEX2 3

External Ids for BEX1 Gene

Previous GeneCards Identifiers for BEX1 Gene

  • GC0XM097619
  • GC0XM099226
  • GC0XM100350
  • GC0XM101089
  • GC0XM102123
  • GC0XM102204
  • GC0XM102317
  • GC0XM091981

Summaries for BEX1 Gene

GeneCards Summary for BEX1 Gene

BEX1 (Brain Expressed, X-Linked 1) is a Protein Coding gene. Diseases associated with BEX1 include ischemic optic neuropathy. Among its related pathways are p75(NTR)-mediated signaling. GO annotations related to this gene include RNA polymerase II activating transcription factor binding. An important paralog of this gene is NGFRAP1.

UniProtKB/Swiss-Prot for BEX1 Gene

  • Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

Gene Wiki entry for BEX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX1 Gene

Genomics for BEX1 Gene

Regulatory Elements for BEX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BEX1 Gene

Start:
103,062,651 bp from pter
End:
103,064,240 bp from pter
Size:
1,590 bases
Orientation:
Minus strand

Genomic View for BEX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BEX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX1 Gene

Proteins for BEX1 Gene

  • Protein details for BEX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH7-BEX1_HUMAN
    Recommended name:
    Protein BEX1
    Protein Accession:
    Q9HBH7
    Secondary Accessions:
    • A0AVN1
    • A8K4J3
    • Q9NZ33

    Protein attributes for BEX1 Gene

    Size:
    125 amino acids
    Molecular mass:
    14860 Da
    Quaternary structure:
    • Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).

neXtProt entry for BEX1 Gene

Proteomics data for BEX1 Gene at MOPED

Post-translational modifications for BEX1 Gene

  • Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).
  • Ubiquitinated. Degraded by the proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX1 Gene

Domains for BEX1 Gene

Protein Domains for BEX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBH7

UniProtKB/Swiss-Prot:

BEX1_HUMAN :
  • Q9HBH7
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX1: view

No data available for Gene Families for BEX1 Gene

Function for BEX1 Gene

Molecular function for BEX1 Gene

UniProtKB/Swiss-Prot Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

Gene Ontology (GO) - Molecular Function for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16314316
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEX1: view
genes like me logo Genes that share phenotypes with BEX1: view

Animal Model Products

CRISPR Products

miRNA for BEX1 Gene

miRTarBase miRNAs that target BEX1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BEX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BEX1 Gene

Localization for BEX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEX1 Gene COMPARTMENTS Subcellular localization image for BEX1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IDA 16314316
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BEX1: view

Pathways for BEX1 Gene

SuperPathways for BEX1 Gene

Superpath Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with BEX1: view

Pathways by source for BEX1 Gene

1 BioSystems pathway for BEX1 Gene

Gene Ontology (GO) - Biological Process for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16314316
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA 16314316
genes like me logo Genes that share ontologies with BEX1: view

Transcripts for BEX1 Gene

mRNA/cDNA for BEX1 Gene

(181) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEX1 Gene

Brain expressed, X-linked 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BEX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEX1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for BEX1 Gene

GeneLoc Exon Structure for
BEX1
ECgene alternative splicing isoforms for
BEX1

Expression for BEX1 Gene

mRNA expression in normal human tissues for BEX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEX1 Gene

This gene is overexpressed in Brain - Hypothalamus (5.1), Brain - Frontal Cortex (BA9) (4.7), Brain - Anterior cingulate cortex (BA24) (4.6), Brain - Amygdala (4.6), and Brain - Cortex (4.2).

SOURCE GeneReport for Unigene cluster for BEX1 Gene Hs.334370

mRNA Expression by UniProt/SwissProt for BEX1 Gene

Q9HBH7-BEX1_HUMAN
Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
genes like me logo Genes that share expressions with BEX1: view

In Situ Assay Products

No data available for Protein expression for BEX1 Gene

Orthologs for BEX1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEX1 35
  • 99.73 (n)
  • 99.2 (a)
BEX1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BEX2 36
  • 79 (a)
ManyToMany
BEX2 36
  • 77 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Bex1 16
Bex1 36
  • 69 (a)
ManyToMany
Bex2 35
  • 81.6 (n)
  • 75.2 (a)
Bex2 36
  • 72 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Bex2 35
  • 84.27 (n)
  • 77.6 (a)
Species with no ortholog for BEX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX1 Gene

ENSEMBL:
Gene Tree for BEX1 (if available)
TreeFam:
Gene Tree for BEX1 (if available)

Paralogs for BEX1 Gene

Paralogs for BEX1 Gene

Selected SIMAP similar genes for BEX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX1: view

Variants for BEX1 Gene

Sequence variations from dbSNP and Humsavar for BEX1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs709033 -- 103,063,218(-) AACCA(A/G)GAAAA reference, synonymous-codon
rs709034 -- 103,063,167(-) GCCCT(A/C)CCTTT synonymous-codon, reference
rs709035 -- 103,063,160(-) CTTTG(A/G)ATGCT missense, reference
rs709036 - 103,063,156(-) GGATG(C/T)TGGTG reference, missense
rs709037 -- 103,063,154(-) ATGCT(A/G)GTGAA missense, reference

Relevant External Links for BEX1 Gene

HapMap Linkage Disequilibrium report
BEX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEX1 Gene

Disorders for BEX1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BEX1 Gene including...

Search for BEX1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BEX1 Gene

genes like me logo Genes that share disorders with BEX1: view

No data available for UniProtKB/Swiss-Prot for BEX1 Gene

Publications for BEX1 Gene

  1. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. (PMID: 11989783) Yang Q.-S. … Mao Y.-M. (Biochem. Genet. 2002) 3 4 23
  2. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PMID: 16314316) Han C. … Peng X. (Nucleic Acids Res. 2005) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Expression of BEX1 in acute myeloid leukemia with MLL rearrangements. (PMID: 15920485) Quentmeier H. … Drexler H.G. (Leukemia 2005) 3 4

Products for BEX1 Gene

Sources for BEX1 Gene

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