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Aliases for BEX1 Gene

Aliases for BEX1 Gene

  • Brain Expressed X-Linked 1 2 3 5
  • Brain-Expressed X-Linked Protein 1 3 4
  • Ovarian Granulosa Cell 13.0 KDa Protein HGR74 3
  • Brain Expressed, X-Linked 1 3
  • HGR74-H 3
  • HBEX2 3
  • BEX2 3

External Ids for BEX1 Gene

Previous GeneCards Identifiers for BEX1 Gene

  • GC0XM097619
  • GC0XM099226
  • GC0XM100350
  • GC0XM101089
  • GC0XM102123
  • GC0XM102204
  • GC0XM102317
  • GC0XM091981

Summaries for BEX1 Gene

GeneCards Summary for BEX1 Gene

BEX1 (Brain Expressed X-Linked 1) is a Protein Coding gene. Among its related pathways are p75(NTR)-mediated signaling. GO annotations related to this gene include RNA polymerase II activating transcription factor binding. An important paralog of this gene is BEX2.

UniProtKB/Swiss-Prot for BEX1 Gene

  • Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

Gene Wiki entry for BEX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX1 Gene

Genomics for BEX1 Gene

Regulatory Elements for BEX1 Gene

Enhancers for BEX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BEX1 on UCSC Golden Path with GeneCards custom track

Promoters for BEX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BEX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEX1 Gene

Chromosome:
X
Start:
103,062,651 bp from pter
End:
103,064,240 bp from pter
Size:
1,590 bases
Orientation:
Minus strand

Genomic View for BEX1 Gene

Genes around BEX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX1 Gene

Proteins for BEX1 Gene

  • Protein details for BEX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH7-BEX1_HUMAN
    Recommended name:
    Protein BEX1
    Protein Accession:
    Q9HBH7
    Secondary Accessions:
    • A0AVN1
    • A8K4J3
    • Q9NZ33

    Protein attributes for BEX1 Gene

    Size:
    125 amino acids
    Molecular mass:
    14860 Da
    Quaternary structure:
    • Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).

neXtProt entry for BEX1 Gene

Proteomics data for BEX1 Gene at MOPED

Post-translational modifications for BEX1 Gene

  • Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).
  • Ubiquitinated. Degraded by the proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX1 Gene

Domains & Families for BEX1 Gene

Gene Families for BEX1 Gene

Protein Domains for BEX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBH7

UniProtKB/Swiss-Prot:

BEX1_HUMAN :
  • Belongs to the BEX family.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX1: view

Function for BEX1 Gene

Molecular function for BEX1 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).
genes like me logo Genes that share phenotypes with BEX1: view

Animal Models for BEX1 Gene

MGI Knock Outs for BEX1:
  • Bex2 tm1b(EUCOMM)Hmgu

Animal Model Products

miRNA for BEX1 Gene

miRTarBase miRNAs that target BEX1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BEX1 Gene

Localization for BEX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEX1 Gene COMPARTMENTS Subcellular localization image for BEX1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for BEX1 Gene

Pathways & Interactions for BEX1 Gene

SuperPathways for BEX1 Gene

Superpath Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with BEX1: view

Pathways by source for BEX1 Gene

1 BioSystems pathway for BEX1 Gene

Gene Ontology (GO) - Biological Process for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16314316
genes like me logo Genes that share ontologies with BEX1: view

No data available for SIGNOR curated interactions for BEX1 Gene

Drugs & Compounds for BEX1 Gene

No Compound Related Data Available

Transcripts for BEX1 Gene

mRNA/cDNA for BEX1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(181) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEX1 Gene

Brain expressed, X-linked 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEX1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for BEX1 Gene

GeneLoc Exon Structure for
BEX1
ECgene alternative splicing isoforms for
BEX1

Expression for BEX1 Gene

mRNA expression in normal human tissues for BEX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEX1 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Frontal Cortex (BA9) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Amygdala (x4.6), and Brain - Cortex (x4.2).

SOURCE GeneReport for Unigene cluster for BEX1 Gene Hs.334370

mRNA Expression by UniProt/SwissProt for BEX1 Gene

Q9HBH7-BEX1_HUMAN
Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
genes like me logo Genes that share expression patterns with BEX1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BEX1 Gene

Orthologs for BEX1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Bex2 35
  • 81.6 (n)
  • 75.2 (a)
Bex2 16
Bex1 36
  • 69 (a)
ManyToMany
Bex2 36
  • 72 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia BEX1 35
  • 99.73 (n)
  • 99.2 (a)
BEX1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bex2 35
  • 84.27 (n)
  • 77.6 (a)
cow
(Bos Taurus)
Mammalia BEX2 36
  • 79 (a)
ManyToMany
BEX2 36
  • 77 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
Species with no ortholog for BEX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX1 Gene

ENSEMBL:
Gene Tree for BEX1 (if available)
TreeFam:
Gene Tree for BEX1 (if available)

Paralogs for BEX1 Gene

Paralogs for BEX1 Gene

(4) SIMAP similar genes for BEX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX1: view

Variants for BEX1 Gene

Sequence variations from dbSNP and Humsavar for BEX1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs709036 - 103,063,156(-) GGATG(C/G/T)TGGTG reference, missense
rs1045082 - 103,063,077(-) GATAT(A/G)ATGCA reference, missense
rs3174500 - 103,063,250(-) GAGCA(G/T)TAAAC reference, missense
rs1045058 - 103,063,243(-) AAACA(A/G)TCTCA reference, missense
rs1045061 - 103,063,237(-) TCTCA(G/T)CATGG reference, missense

Variation tolerance for BEX1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BEX1 Gene

Disorders for BEX1 Gene

Relevant External Links for BEX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEX1

No disorders were found for BEX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX1 Gene

Publications for BEX1 Gene

  1. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. (PMID: 11989783) Yang Q.-S. … Mao Y.-M. (Biochem. Genet. 2002) 3 4 23 67
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  3. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PMID: 16314316) Han C. … Peng X. (Nucleic Acids Res. 2005) 3 23
  4. Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs. (PMID: 25612294) Fernandez E.M. … Vilar M. (PLoS ONE 2015) 3
  5. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3

Products for BEX1 Gene

Sources for BEX1 Gene

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