Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BEX1 Gene

protein-coding   GIFtS: 52
GCID: GC0XM102317

brain expressed, X-linked 1
 Explore 7 diseases affiliated with
BEX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BEX1    

Aliases
for BEX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Brain Expressed, X-Linked 11 2     HGR74-H1
Brain-Expressed X-Linked Protein 12 3     Ovarian Granulosa Cell 13.0 KDa Protein HGR742
BEX22     Protein BEX12
HBEX22     

External Ids:    HGNC: 10361   Entrez Gene: 558592   Ensembl: ENSG000001331697   OMIM: 3006905   UniProtKB: Q9HBH73   

Export aliases for BEX1 gene to outside databases

Previous GC identifers: GC0XM097619 GC0XM099226 GC0XM100350 GC0XM101089 GC0XM102123 GC0XM102204 GC0XM091981


Summaries
for BEX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and
neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a
link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of
receptor signaling, coordinating biological responses to external signals with internal cellular states (By
similarity)

Gene Wiki entry for BEX1


Genomic Views
for BEX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BEX1 gene promoter:
         TBP   AML1a   Pax-2   Pax-2a   LCR-F1   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BEX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BEX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1|Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

BEX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEX1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102317:  view genomic region     (about GC identifiers)

Start:
 102,317,579 bp from pter      End:
 102,319,168 bp from pter
Size:
 1,590 bases      Orientation:
 minus strand

Proteins
for BEX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7 (See protein sequence)
Recommended Name: Protein BEX1  
Size: 125 amino acids; 14860 Da
Subunit: Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus (By similarity)
Caution: Was named BEX2 by some authors
Secondary accessions: A0AVN1 A8K4J3 Q9NZ33

Explore the universe of human proteins at neXtProt for BEX1: NX_Q9HBH7

Post-translational modifications:

  • Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity)1
  • Ubiquitinated. Degraded by the proteasome (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBH7

    • BEX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060946.3  
    ENSEMBL proteins: 
     ENSP00000361813  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: BEX1
    OriGene Protein Over-expression Lysate: BEX1
    OriGene Custom Protein Services for BEX1 
    GenScript Custom Purified and Recombinant Proteins Services for BEX1
    Novus Biologicals BEX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BEX1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IDA16314316
    GO:0005737cytoplasm IEA--


    BEX1 for ontologies           About GeneDecksing



    BEX1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BEX1 
    GenScript Custom Superior Antibodies Services for BEX1
    Novus Biologicals BEX1 Antibody
    Search for Antibodies for BEX1 at Abcam  
    Uscn Antibodies for BEX1
    ThermoFisher Antibody for BEX1

    Assay Products for BEX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BEX1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BEX1

    Protein Domains /
    Families
    for BEX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BEX1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021156 TF_A-like/BEX-like
     IPR007623 BEX

    Graphical View of Domain Structure for InterPro Entry Q9HBH7

    ProtoNet protein and cluster: Q9HBH7

    UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
    Similarity: Belongs to the BEX family


    Function
    for BEX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
    Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and
    neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a
    link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of
    receptor signaling, coordinating biological responses to external signals with internal cellular states (By
    similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: BEX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BEX1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate BEX1
    SwitchGear 3'UTR luciferase reporter plasmid: BEX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BEX1 (see all 4)
    OriGene shRNA RFP: BEX1
    OriGene siRNA: BEX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BEX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BEX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BEX1 (NM_018476)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEX1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BEX1
    Search LifeMap BioReagents cell lines for BEX1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEX1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IPI16314316


    BEX1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BEX1:
     Upregulation of NF-kappaB path 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bex1):
     homeostasis/metabolism  muscle 

    BEX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BEX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1p75(NTR)-mediated signaling
    		p75(NTR)-mediated signaling1.00


    1 BioSystems Pathway for BEX1 
        p75(NTR)-mediated signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BEX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for BEX1 (Q9HBH72, 3 ENSP000003618134) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8256921 I2D: score=2 
    NGFRP081383, ENSP000001722294I2D: score=1 STRING: ENSP00000172229
    OMPP478743I2D: score=3 
    NGFENSP000003585254STRING: ENSP00000358525
    RIPK2ENSP000002207514STRING: ENSP00000220751
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA16314316
    GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity IDA16314316


    BEX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BEX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BEX1
    Search CenterWatch for drugs/clinical trials and news about BEX1 

    Transcripts
    for BEX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BEX1 gene: 
    NM_018476.3  

    Unigene Cluster for BEX1:

    Brain expressed, X-linked 1
    Hs.334370  [show with all ESTs]
    Unigene Representative Sequence: BM804232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372728(uc004ejt.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: BEX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BEX1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate BEX1
    SwitchGear 3'UTR luciferase reporter plasmid: BEX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BEX1 (see all 4)
    OriGene shRNA RFP: BEX1
    OriGene siRNA: BEX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BEX1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BEX1 (NM_018476)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEX1
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat BEX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEX1

    Additional cDNA sequence: 

    AF183416.1 AF220189.1 AF237783.1 AK290958.1 AY833561.1 BC018615.2 BC105298.1 BC126427.1 
    BC126429.1 

    7 DOTS entries:

    DT.121305858  DT.121305599  DT.100817093  DT.449419  DT.121305745  DT.95112426  DT.95255948 

    24/181 AceView cDNA sequences (see all 181):

    BI711306 BU948036 CA848659 CR613496 BC018615 W68339 CB177549 AA364196 
    BQ128208 BG654791 BI712924 BF971303 AV726008 BG656300 BU950090 CD108600 
    AW087092 CA866502 AA916558 CA848365 W60582 BM510819 BF513905 BU070439 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BEX1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for BEX1

    Expression
    for BEX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BEX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BEX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    OvaryAntral FollicleCumulus CellsOvary
    KidneyRenal Collecting Duct SystemKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BEX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BEX1

    SOURCE GeneReport for Unigene cluster: Hs.334370

    UniProtKB/Swiss-Prot: BEX1_HUMAN, Q9HBH7
    Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe.
    Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly
    expressed in acute myeloid leukemia

        SABiosciences Custom PCR Arrays for BEX1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEX1
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat BEX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEX1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEX1

    Orthologs
    for BEX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for BEX1 (if available)
    TreeFam Gene Tree for BEX1 (if available) 

    Paralogs
    for BEX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BEX1 gene
    BEX52  BEX22  NGFRAP12  BEX42  
    4 SIMAP similar genes for BEX1 using alignment to 1 protein entry:     BEX1_HUMAN:
    BEX2    BEX4    BEX5    NGFRAP1

    BEX1 for paralogs           About GeneDecksing



    Genomic Variants
    for BEX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 NCBI SNPs in BEX1 are shown (see all 109)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1849454091,2
    		--102317148(+) ACTTAC/TAAATG 1 -- ds50010--------
    rs59876651,2
    		C,H,--102317235(+) CACAAA/CAGACA 1 -- ds50016Minor allele frequency- C:0.00WA NA CSA 8
    rs1901955241,2
    		--102317720(+) CCCACA/GTAAAC 1 -- ut310--------
    rs10452031,2
    		--102317740(-) TAAACC/G/TTTTAC 2 -- ut313MN NA 188
    rs1998515191,2
    		--102317787(+) CAGGGG/TTCTGT 1 -- ut310--------
    rs1483082041,2
    		C--102317887(+) TGCCCG/ACAGAC 2 /R /W mis11Minor allele frequency- A:0.00NA 4552
    rs1414640741,2
    		C--102317952(+) CAATCC/TTTTCC 2 K R mis11Minor allele frequency- T:0.00NA 4552
    rs10450821,2
    		C,H--102318005(-) GATATG/AATGCA 2 /I /M mis19Minor allele frequency- A:0.20MN NS EA NA 962
    rs1382192421,2
    		C--102318025(+) CTGCAG/CGATGG 2 /L /V mis11Minor allele frequency- C:0.00NA 4552
    rs7090361,2
    		C,H--102318084(-) GGATGC/TTGGTG 2 A V mis1 ese37Minor allele frequency- T:0.04MN NS EA NA 606

    HapMap Linkage Disequilibrium report for BEX1 (102317579 - 102319168 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BEX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEX1
    DNA2.0 Custom Variant and Variant Library Synthesis for BEX1

    Disorders / Diseases
    for BEX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BEX1 for disorders           About GeneDecksing

    OMIM gene information: 300690    OMIM disorders: --

    7 diseases for BEX1:    About MalaCards
    ischemic optic neuropathy    acute myeloid leukemia    myeloid leukemia    malignant glioma
    neuropathy    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for BEX1:
    Ischemic optic neuropathy

    Export disorders for BEX1 gene to outside databases

    Publications
    for BEX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BEX1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with BEX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. (PubMed id 11989783)1, 2, 9 Yang Q.-S.... Mao Y.-M. (2002)
    2. Expression of BEX1 in acute myeloid leukemia with MLL rearrangements. (PubMed id 15920485)1, 2 Quentmeier H....Drexler H.G. (2005)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. Characterization of the Bex gene family in humans, mice, and rats. (PubMed id 15958283)1, 2 Alvarez E.... Freed C.R. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PubMed id 16314316)1, 9 Han C.... Peng X. (2005)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/Abl+ leukemic cells. (PubMed id 19028701)1 Ding K....Zhu Y. (2009)
    9. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (PubMed id 16818640)1 Foltz G....Madan A. (2006)
    10. Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. (PubMed id 16498402)1 Vilar M....Ibanez C.F. (2006)

    External Searches for BEX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BEX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55859 HGNC: 1036 AceView: BEX1 Ensembl:ENSG00000133169 euGenes: HUgn55859
    ECgene: BEX1 H-InvDB: BEX1

    Other Databases showing BEX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BEX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BEX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BEX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BEX1 gene:
    Search GeneIP for patents involving BEX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BEX1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for BEX1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BEX1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEX1  
     OriGene Protein Over-expression Lysate for BEX1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BEX1   OriGene 3'-UTR Clone for BEX1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEX1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEX1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for BEX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BEX1   OriGene Custom Protein Services for BEX1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BEX1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BEX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEX1
     GenScript Custom Purified and Recombinant Proteins Services for BEX1 GenScript cDNA clones with any tag delivered in your preferred vector for BEX1
     GenScript Custom Assay Services for BEX1 GenScript Custom Superior Antibodies Services for BEX1
     GenScript Custom overexpressing Cell Line Services for BEX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BEX1 promoter
     Search Chromatin IP Primers for BEX1
     RT2 qPCR Primer Assay in human, mouse / rat BEX1
     GNC Network for BEX1
     SABiosciences Custom PCR Arrays for BEX1
     Search Tocris compounds for BEX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BEX1 antibodies
     BEX1 lysates
     Search for Antibodies for BEX1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for BEX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     BEX1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BEX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEX1
     SwitchGear 3'UTR luciferase reporter plasmids for BEX1
     SwitchGear Promoter luciferase reporter plasmids for BEX1
     ThermoFisher Antibody for BEX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEX1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      BEX1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4