BET3L Gene
protein-coding GIFtS: 40
GCID: GC06M116816
|
|
BET3 like (S. cerevisiae)
| |
Aliases
for BET3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BET3 Like (S. Cerevisiae)1 2 | | FLJ111801 | | BA259P20.21 | | TRAPPC3L2 | | BET3-Like Protein2 3 | | Trafficking Protein Particle Complex Subunit 3-Like Protein2 | | TRAPPC3-Like Protein2 3 | | |
Export aliases for BET3L gene to outside databasesPrevious GC identifers: GC06U900429 GC06M116922 GC06M114397 |
Summaries
for BET3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)
|
Genomic Views
for BET3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BET3L gene promoter:
Nkx3-1 Nkx3-1 v4 Brachyury Nkx3-1 v1 Nkx2-5 MZF-1 Nkx3-1 v2 FAC1 HSF2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for BET3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BET3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22.1 Ensembl cytogenetic band: 6q22.1 HGNC cytogenetic band: 6q22.31BET3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M116816: view genomic region
(about GC identifiers)
Start:
|
116,816,152 bp from pter |
End:
|
116,866,773 bp from pter |
Size:
|
50,622 bases |
Orientation:
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minus strand |
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Proteins
for BET3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215 (See
protein sequence)Recommended Name: Trafficking protein particle complex subunit 3-like protein Size: 181 amino acids; 20566 Da
Subunit: Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at leastTRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12
Subcellular location: Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity)
Secondary accessions: Q5T213 Q5T214Alternative splicing: 2 isoforms: Q5T215-1 Q5T215-2 Explore the universe of human proteins at neXtProt for BET3L: NX_Q5T215
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T215
BET3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001132916.1
ENSEMBL proteins: ENSP00000348445 ENSP00000395769 ENSP00000357591
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IEA | -- | | GO:0005794 | Golgi apparatus |
IEA | -- |
BET3L for ontologies About GeneDecksing
BET3L Antibody Products:
Assay Products for BET3L: |
Protein
Domains /
Families
for BET3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BET3L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T215ProtoNet protein and cluster: Q5T215 1 Blocks protein family: IPB007194 Transport protein particle (TRAPP) component
UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215Similarity: Belongs to the TRAPP small subunits family. BET3 subfamily |
Function
for BET3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TPC3L_HUMAN, Q5T215Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BET3L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BET3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BET3L (NM_001139444) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BET3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BET3L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BET3L |
|
Pathways & Interactions
for BET3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BET3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for BET3L (ENSP000003575914) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016192 | vesicle-mediated transport |
IEA | -- |
BET3L for ontologies About GeneDecksing
|
Drugs & Compounds
for BET3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BET3L
Search CenterWatch for drugs/clinical trials and news about BET3L / TPC3L
|
Transcripts
for BET3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BET3L gene: NM_001139444.2 Unigene Cluster for BET3L: BET3 like (S. cerevisiae) Hs.134795 [show with all ESTs]Unigene Representative Sequence: AK0020423 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356128(uc003pwx.3) ENST00000437098(uc003pww.3) ENST00000368602(uc011ebh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BET3L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BET3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BET3L (NM_001139444) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BET3L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BET3L |
Additional cDNA sequence: AK002042.1 BC127757.1 BC127758.1 4 DOTS entries: DT.99943832 DT.121396356 DT.70104927 DT.92002612
GeneLoc Exon Structure
|
Expression
for BET3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BET3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See BET3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BET3L
SOURCE GeneReport for Unigene cluster: Hs.134795
SABiosciences Custom PCR Arrays for BET3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BET3L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BET3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BET3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BET3L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BET3L |
Orthologs
for BET3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for BET3L gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Bet3l1 , 5 |
BET3 like (S. cerevisiae)1, 5 |
89.5(n)1
92.82(a)1 |
|
10 (18.85 cM)5
6921321 NM_001162937.11 NP_001156409.11
340375975 |
chicken
(Gallus gallus) |
Aves |
BET3L1 |
BET3 like (S. cerevisiae) |
72.04(n)
76.67(a) |
|
421743 XM_419775.3 XP_419775.1 |
lizard
(Anolis carolinensis) |
Reptilia |
BET3L6 |
-- |
74(a) |
1 ↔ 1 |
1(186208825-186217433) |
zebrafish
(Danio rerio) |
Actinopterygii |
trappc36 |
trafficking protein particle complex 3 |
62(a) |
1 → many |
19(37271262-37281761) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Bet36 |
-- |
46(a) |
1 → many |
3L(9431582-9435367) |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK1098.56 |
Probable trafficking protein particle complex subu... |
39(a) |
1 → many |
III(9525466-9526996) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G547506 |
Transport protein particle (TRAPP) component |
43(a) |
1 → many |
5(22241481-22243721) |
rice
(Oryza sativa) |
Liliopsida |
---- |
transport protein particle component, Bet3, domain...transport protein particle component, Bet3, domain... |
44(a)44(a) |
many ↔ manymany ↔ many |
3(16357315-16360940) 7(26730012-26732361) |
ENSEMBL Gene Tree for BET3L (if available)
TreeFam Gene Tree for BET3L (if available) |
Paralogs
for BET3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BET3L gene
- TRAPPC32
1 SIMAP similar gene for BET3L using alignment to 1 protein entry: TPC3L_HUMAN:TRAPPC3
BET3L for paralogs About GeneDecksing
|
Genomic Variants
for BET3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BET3L (116816152 - 116866773 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BET3L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BET3L |
|
Disorders
/ Diseases
for BET3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BET3L for disorders About GeneDecksing
OMIM gene information: 614137
OMIM disorders: --
2  diseases for BET3L: About MalaCardsconjunctivitis malaria
Human Genome Epidemiology (HuGE) Navigator: BET3L (1 document)
Export disorders for BET3L gene to outside databases
|
Publications
for BET3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BET3L gene integrated from 9 sources:
(articles sorted by number of sources associating them with BET3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- C4orf41 and TTC-15 are mammalian TRAPP components wit h a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2 Scrivens P.J....Sacher M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BET3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BET3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BET3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BET3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BET3L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BET3L gene:
Search GeneIP for patents involving BET3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BET3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BET3L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BET3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BET3L | | | OriGene Protein Over-expression Lysate for BET3L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BET3L | | OriGene 3'-UTR Clone for BET3L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BET3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BET3L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BET3L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BET3L | | OriGene Custom Protein Services for BET3L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BET3L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BET3L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BET3L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BET3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BET3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BET3L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BET3L |
| |  |  |  |  | | | | |
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 |
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 | | | BET3L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BET3L |
|  |  |  | | | | ThermoFisher Antibody for BET3L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BET3L |
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