Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BET1L Gene

Aliases for BET1L Gene

  • Bet1 Golgi Vesicular Membrane Trafficking Protein Like 2 3 5
  • Bet1 Golgi Vesicular Membrane Trafficking Protein-Like 2 3
  • Golgi Integral Membrane Protein 3 2 3
  • Golgi SNARE With A Size Of 15 KDa 3 4
  • Vesicle Transport Protein GOS15 3 4
  • GOS-15 3 4
  • GS15 3 4
  • Blocked Early In Transport 1 Homolog (S. Cerevisiae) Like 2
  • Blocked Early In Transport 1 Homolog (S. Cerevisiae)-Like 2
  • Blocked Early In Transport 1 Homolog-Like 3
  • Golgi SNARE 15 KDa Protein 3
  • HSPC197 3
  • BET1L1 3
  • GOLIM3 3

External Ids for BET1L Gene

Previous GeneCards Identifiers for BET1L Gene

  • GC11U990259
  • GC11P000102
  • GC11P000991
  • GC11M000022

Summaries for BET1L Gene

GeneCards Summary for BET1L Gene

BET1L (Bet1 Golgi Vesicular Membrane Trafficking Protein Like) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Normal wtCFTR traffic / ER-to-Golgi. GO annotations related to this gene include SNAP receptor activity. An important paralog of this gene is BET1.

UniProtKB/Swiss-Prot for BET1L Gene

  • Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).

Gene Wiki entry for BET1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BET1L Gene

Genomics for BET1L Gene

Regulatory Elements for BET1L Gene

Promoters for BET1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BET1L on UCSC Golden Path with GeneCards custom track

Genomic Location for BET1L Gene

Chromosome:
11
Start:
167,784 bp from pter
End:
207,428 bp from pter
Size:
39,645 bases
Orientation:
Minus strand

Genomic View for BET1L Gene

Genes around BET1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BET1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BET1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BET1L Gene

Proteins for BET1L Gene

  • Protein details for BET1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYM9-BET1L_HUMAN
    Recommended name:
    BET1-like protein
    Protein Accession:
    Q9NYM9
    Secondary Accessions:
    • B3KMY0

    Protein attributes for BET1L Gene

    Size:
    111 amino acids
    Molecular mass:
    12388 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.

neXtProt entry for BET1L Gene

Proteomics data for BET1L Gene at MOPED

Post-translational modifications for BET1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BET1L Gene

Antibody Products

No data available for DME Specific Peptides for BET1L Gene

Domains & Families for BET1L Gene

Gene Families for BET1L Gene

Protein Domains for BET1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BET1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYM9

UniProtKB/Swiss-Prot:

BET1L_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
genes like me logo Genes that share domains with BET1L: view

Function for BET1L Gene

Molecular function for BET1L Gene

UniProtKB/Swiss-Prot Function:
Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).

Gene Ontology (GO) - Molecular Function for BET1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IEA,IDA 15215310
genes like me logo Genes that share ontologies with BET1L: view
genes like me logo Genes that share phenotypes with BET1L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BET1L Gene

Localization for BET1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BET1L Gene

Golgi apparatus membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane. Note=Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BET1L Gene COMPARTMENTS Subcellular localization image for BET1L gene
Compartment Confidence
golgi apparatus 5
endosome 4
cytosol 3
nucleus 2
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BET1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome IDA 15215310
GO:0005795 Golgi stack IEA --
GO:0005829 cytosol IDA 15215310
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BET1L: view

Pathways & Interactions for BET1L Gene

genes like me logo Genes that share pathways with BET1L: view

Pathways by source for BET1L Gene

Gene Ontology (GO) - Biological Process for BET1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061025 membrane fusion IEA,IDA --
genes like me logo Genes that share ontologies with BET1L: view

No data available for SIGNOR curated interactions for BET1L Gene

Drugs & Compounds for BET1L Gene

No Compound Related Data Available

Transcripts for BET1L Gene

Unigene Clusters for BET1L Gene

Bet1 golgi vesicular membrane trafficking protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BET1L Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: -
SP7: -
SP8: - - -
SP9: - - -

Relevant External Links for BET1L Gene

GeneLoc Exon Structure for
BET1L
ECgene alternative splicing isoforms for
BET1L

Expression for BET1L Gene

mRNA expression in normal human tissues for BET1L Gene

Protein differential expression in normal tissues from HIPED for BET1L Gene

This gene is overexpressed in Bone (29.0) and Peripheral blood mononuclear cells (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BET1L Gene



SOURCE GeneReport for Unigene cluster for BET1L Gene Hs.414418

genes like me logo Genes that share expression patterns with BET1L: view

Protein tissue co-expression partners for BET1L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BET1L Gene

Orthologs for BET1L Gene

This gene was present in the common ancestor of animals.

Orthologs for BET1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BET1L 35
  • 88.59 (n)
  • 96.4 (a)
BET1L 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BET1L 35
  • 88.29 (n)
  • 93.69 (a)
BET1L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bet1l 35
  • 84.38 (n)
  • 90.99 (a)
Bet1l 16
Bet1l 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BET1L 35
  • 98.8 (n)
  • 98.2 (a)
BET1L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bet1l 35
  • 85.29 (n)
  • 90.99 (a)
oppossum
(Monodelphis domestica)
Mammalia BET1L 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BET1L 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves BET1L 35
  • 73.87 (n)
  • 73.87 (a)
BET1L 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BET1L 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bet1l 35
  • 66.07 (n)
  • 64.86 (a)
zebrafish
(Danio rerio)
Actinopterygii bet1l 35
  • 67.58 (n)
  • 70.64 (a)
bet1l 36
  • 37 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1115 35
fruit fly
(Drosophila melanogaster)
Insecta Bet1 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nbet-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for BET1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BET1L Gene

ENSEMBL:
Gene Tree for BET1L (if available)
TreeFam:
Gene Tree for BET1L (if available)

Paralogs for BET1L Gene

Paralogs for BET1L Gene

(3) SIMAP similar genes for BET1L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BET1L: view

Variants for BET1L Gene

Sequence variations from dbSNP and Humsavar for BET1L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs14677 -- 203,292(+) AAGTA(A/C)CTGGG utr-variant-3-prime
rs1045454 -- 204,228(-) TCTTC(C/T)CACCT utr-variant-3-prime
rs939917 -- 202,547(+) gaacc(C/T)ggaga downstream-variant-500B
rs2280543 -- 203,788(+) GTCAA(C/T)CTTGC utr-variant-3-prime
rs2280544 -- 204,062(+) GGACA(C/T)ATGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BET1L Gene

Variant ID Type Subtype PubMed ID
dgv910n71 CNV Gain 21882294
esv22231 CNV Gain 19812545
nsv896436 CNV Gain 21882294
nsv896437 CNV Loss 21882294
dgv911n71 CNV Gain 21882294
nsv467630 CNV Gain 19166990
nsv522596 CNV Gain 19592680
nsv467631 CNV Gain 19166990
nsv896439 CNV Loss 21882294
nsv896440 CNV Gain 21882294

Variation tolerance for BET1L Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BET1L Gene

HapMap Linkage Disequilibrium report
BET1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BET1L Gene

Disorders for BET1L Gene

Relevant External Links for BET1L

Genetic Association Database (GAD)
BET1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BET1L

No disorders were found for BET1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BET1L Gene

Publications for BET1L Gene

  1. Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (PMID: 22286173) Low S.K. … Nakamura Y. (Hum. Mol. Genet. 2012) 3 48 67
  2. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3
  3. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. (PMID: 15215310) Tai G. … Hong W. (Mol. Biol. Cell 2004) 3 23
  4. GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. (PMID: 12388752) Xu Y. … Hong W. (Mol. Biol. Cell 2002) 3 23
  5. GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1. (PMID: 9242691) Xu Y. … Hong W. (J. Biol. Chem. 1997) 2 3

Products for BET1L Gene

Sources for BET1L Gene

Back to Top

Content