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Aliases for BET1 Gene

Aliases for BET1 Gene

  • Bet1 Golgi Vesicular Membrane Trafficking Protein 2 3
  • Golgi Vesicular Membrane Trafficking Protein P18 2 3
  • Golgi Vesicular Membrane-Trafficking Protein P18 3 4
  • Bet1p Homolog 2 3
  • HBET1 3 4
  • Blocked Early In Transport 1 Homolog (S. Cerevisiae) 2
  • Blocked Early In Transport 1 Homolog 3
  • Bet1 (S. Cerevisiae) Homolog 2
  • BET1 Homolog (S. Cerevisiae) 2

External Ids for BET1 Gene

Previous GeneCards Identifiers for BET1 Gene

  • GC07M092157
  • GC07M093220
  • GC07M093234
  • GC07M093267
  • GC07M093430
  • GC07M093592
  • GC07M088228

Summaries for BET1 Gene

Entrez Gene Summary for BET1 Gene

  • This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for BET1 Gene

BET1 (Bet1 Golgi Vesicular Membrane Trafficking Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is BET1L.

UniProtKB/Swiss-Prot for BET1 Gene

  • Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).

Gene Wiki entry for BET1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BET1 Gene

Genomics for BET1 Gene

Regulatory Elements for BET1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BET1 Gene

Chromosome:
7
Start:
93,962,762 bp from pter
End:
94,004,390 bp from pter
Size:
41,629 bases
Orientation:
Minus strand

Genomic View for BET1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BET1 Gene

Proteins for BET1 Gene

  • Protein details for BET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15155-BET1_HUMAN
    Recommended name:
    BET1 homolog
    Protein Accession:
    O15155
    Secondary Accessions:
    • Q96EA0

    Protein attributes for BET1 Gene

    Size:
    118 amino acids
    Molecular mass:
    13289 Da
    Quaternary structure:
    • Interacts with STX17.

    Three dimensional structures from OCA and Proteopedia for BET1 Gene

    Alternative splice isoforms for BET1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BET1 Gene

Proteomics data for BET1 Gene at MOPED

Post-translational modifications for BET1 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for BET1 Gene

No data available for DME Specific Peptides for BET1 Gene

Domains & Families for BET1 Gene

Protein Domains for BET1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15155

UniProtKB/Swiss-Prot:

BET1_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the BET1 family.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
Family:
  • Belongs to the BET1 family.
genes like me logo Genes that share domains with BET1: view

No data available for Gene Families for BET1 Gene

Function for BET1 Gene

Molecular function for BET1 Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).

Gene Ontology (GO) - Molecular Function for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with BET1: view
genes like me logo Genes that share phenotypes with BET1: view

Animal Model Products

miRNA for BET1 Gene

miRTarBase miRNAs that target BET1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BET1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BET1 Gene

Localization for BET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BET1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BET1 Gene COMPARTMENTS Subcellular localization image for BET1 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005801 cis-Golgi network IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BET1: view

Pathways & Interactions for BET1 Gene

genes like me logo Genes that share pathways with BET1: view

Gene Ontology (GO) - Biological Process for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0015031 protein transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with BET1: view

No data available for SIGNOR curated interactions for BET1 Gene

Drugs & Compounds for BET1 Gene

No Compound Related Data Available

Transcripts for BET1 Gene

Unigene Clusters for BET1 Gene

Bet1 golgi vesicular membrane trafficking protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BET1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BET1 Gene

No ASD Table

Relevant External Links for BET1 Gene

GeneLoc Exon Structure for
BET1
ECgene alternative splicing isoforms for
BET1

Expression for BET1 Gene

mRNA expression in normal human tissues for BET1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BET1 Gene

This gene is overexpressed in Bone (18.8), Placenta (13.6), and Breast (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BET1 Gene



SOURCE GeneReport for Unigene cluster for BET1 Gene Hs.489132

genes like me logo Genes that share expression patterns with BET1: view

Protein tissue co-expression partners for BET1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BET1 Gene

Orthologs for BET1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BET1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BET1 35
  • 92.66 (n)
  • 95.76 (a)
BET1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BET1 35
  • 94.63 (n)
  • 97.46 (a)
mouse
(Mus musculus)
Mammalia Bet1 35
  • 92.09 (n)
  • 92.37 (a)
Bet1 16
Bet1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BET1 35
  • 100 (n)
  • 100 (a)
BET1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bet1 35
  • 90.68 (n)
  • 93.22 (a)
oppossum
(Monodelphis domestica)
Mammalia BET1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves BET1 35
  • 78.55 (n)
  • 80.87 (a)
BET1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BET1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730635 35
  • 76.04 (n)
  • 73.96 (a)
Str.15246 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17630 35
zebrafish
(Danio rerio)
Actinopterygii bet1 35
  • 67.55 (n)
  • 70.8 (a)
bet1 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012272 35
  • 47.57 (n)
  • 45.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bet1 35
  • 45.48 (n)
  • 40.19 (a)
Bet1 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nbet-1 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for BET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BET1 Gene

ENSEMBL:
Gene Tree for BET1 (if available)
TreeFam:
Gene Tree for BET1 (if available)

Paralogs for BET1 Gene

Paralogs for BET1 Gene

(2) SIMAP similar genes for BET1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for BET1 Gene

genes like me logo Genes that share paralogs with BET1: view

Variants for BET1 Gene

Sequence variations from dbSNP and Humsavar for BET1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1014424 -- 93,963,534(+) taatt(A/G)actac utr-variant-3-prime
rs2072432 -- 94,003,698(+) AAGTT(A/C)CAGTT intron-variant
rs2072433 -- 94,003,816(+) TTCCG(C/T)TTCTG intron-variant
rs2299416 -- 93,997,787(+) CACCA(C/T)TGATA intron-variant
rs3763472 -- 94,006,082(-) AACGA(A/G)AAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BET1 Gene

Variant ID Type Subtype PubMed ID
esv2540921 CNV Deletion 19546169

Variation tolerance for BET1 Gene

Residual Variation Intolerance Score: 55.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BET1 Gene

HapMap Linkage Disequilibrium report
BET1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BET1 Gene

Disorders for BET1 Gene

Relevant External Links for BET1

Genetic Association Database (GAD)
BET1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BET1
genes like me logo Genes that share disorders with BET1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BET1 Gene

Publications for BET1 Gene

  1. The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle. (PMID: 16735505) Siddiqi S.A. … Mansbach C.M. (J. Biol. Chem. 2006) 23 67
  2. Membrane tethering in intracellular transport. (PMID: 10449330) Waters M.G. … Pfeffer S.R. (Curr. Opin. Cell Biol. 1999) 2 67
  3. The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. (PMID: 9382863) Zhang T. … Hong W. (J. Cell Biol. 1997) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for BET1 Gene

Sources for BET1 Gene

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