BET1 Gene
protein-coding GIFtS: 54
GCID: GC07M093592
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blocked early in transport 1 homolog (S. cerevisiae)(Previous names: Bet1 (S. cerevisiae) homolog, BET1 homolog (S. cerevisiae)...)
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Aliases
for BET1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Blocked Early In Transport 1 Homolog (S. Cerevisiae)1 2 | | HBET12 | | Golgi Vesicular Membrane-Trafficking Protein P182 3 | | BET1 Homolog2 | | Bet1 (S. Cerevisiae) Homolog1 | | Bet1p Homolog2 | | BET1 Homolog (S. Cerevisiae)1 | | Golgi Vesicular Membrane Trafficking Protein P182 | | Hbet11 | | HBET12 |
Export aliases for BET1 gene to outside databasesPrevious GC identifers: GC07M092157 GC07M093220 GC07M093234 GC07M093267 GC07M093430 GC07M088228 |
Summaries
for BET1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BET1:
This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmicreticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factorattachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane.Alternatively spliced transcript variants encoding different isoforms have been described but their full-length naturehas not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BET1_HUMAN, O15155Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in thedocking process of ER-derived vesicles with the cis-Golgi membrane (By similarity)
Gene Wiki entry for BET1
|
Genomic Views
for BET1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BET1 gene promoter:
AhR TBP AML1a Arnt AREB6 SRY TFIID FOXJ2 (long isoform) FOXJ2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for BET1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BET1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.1-q22 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21.1-q22BET1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M093592: view genomic region
(about GC identifiers)
Start:
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93,592,074 bp from pter |
End:
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93,633,694 bp from pter |
Size:
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41,621 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 92,950,170-92,962,860 |
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Proteins
for BET1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BET1_HUMAN, O15155 (See
protein sequence)Recommended Name: BET1 homolog Size: 118 amino acids; 13289 Da
Subcellular location: Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Endoplasmicreticulum membrane; Single-pass type IV membrane protein (By similarity)
1 PDB 3D structure from  and Proteopedia  for BET1:3EGX (3D)
Explore the universe of human proteins at neXtProt for BET1: NX_O15155
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15155
BET1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005859.1
ENSEMBL proteins: ENSP00000350125 ENSP00000222547 ENSP00000391228 ENSP00000401260 ENSP00000413063
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
BET1 for ontologies About GeneDecksing
BET1 Antibody Products:
Assay Products for BET1: |
Protein
Domains /
Families
for BET1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BET1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O15155ProtoNet protein and cluster: O15155 UniProtKB/Swiss-Prot: BET1_HUMAN, O15155Similarity: Belongs to the BET1 familySimilarity: Contains 1 t-SNARE coiled-coil homology domain |
Function
for BET1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BET1_HUMAN, O15155Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in thedocking process of ER-derived vesicles with the cis-Golgi membrane (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BET1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BET1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BET1 (NM_005868) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BET1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BET1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BET1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
BET1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BET1:
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Pathways & Interactions
for BET1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for BET1):
BET1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BET1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/30 Interacting proteins for BET1 (O151551, 3 ENSP000002225474) via UniProtKB, MINT, STRING, and/or I2D (see all 30)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0048280 | vesicle fusion with Golgi apparatus |
IEA | -- |
BET1 for ontologies About GeneDecksing
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Drugs & Compounds
for BET1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BET1
Search CenterWatch for drugs/clinical trials and news about BET1
|
Transcripts
for BET1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BET1 gene: NM_005868.4 Unigene Cluster for BET1: Blocked early in transport 1 homolog (S. cerevisiae) Hs.489132 [show with all ESTs]Unigene Representative Sequence: CR7492676 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357520(uc003une.4) ENST00000471446 ENST00000222547(uc003unf.1)
ENST00000433727 ENST00000457139 ENST00000425626
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BET1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BET1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BET1 (NM_005868) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BET1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BET1 |
Additional cDNA sequence: AF007551.1 AK313984.1 BC000899.1 BC012595.1 BT009853.1 CR749267.1 11 DOTS entries: DT.317797 DT.75163673 DT.100664036 DT.100815597 DT.100815598 DT.92030275 DT.121122583 DT.75140085 DT.91704852 DT.91750540 DT.100698140 24/264 AceView cDNA sequences (see all 264): R73645 AW675479 BF001518 AI433876 AI088252 CR749267 NM_005868 Z41367 AA445962 AI440004 BX396937 BX505568 AA781700 BC000899 AA305267 CR614774 AI767556 AA581604 CR605582 BQ936393 T31927 AA503868 AA278209 BM760543
GeneLoc Exon Structure
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Expression
for BET1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BET1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATCAGTA
About this image
See BET1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BET1
SOURCE GeneReport for Unigene cluster: Hs.489132
SABiosciences Custom PCR Arrays for BET1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BET1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BET1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BET1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BET1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BET1 |
Orthologs
for BET1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for BET1 gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for BET1 (if available)
TreeFam Gene Tree for BET1 (if available) |
Paralogs
for BET1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BET1 gene
- BET1L2
2 SIMAP similar genes for BET1 using alignment to 5 protein entries: BET1_HUMAN (see all proteins):DKFZp781C0425 BET1L
BET1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for BET1
PGOHUM00000244066 PGOHUM00000233649
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Genomic Variants
for BET1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BET1 (93592074 - 93633694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BET1
1 CNV: 100033 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BET1 |
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Disorders
/ Diseases
for BET1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BET1 for disorders About GeneDecksing
OMIM gene information: 605456
OMIM disorders: --
5  diseases for BET1: About MalaCardscomplex v croup vestibular neuronitis pneumothorax
neuronitis
1 disease from the University of Copenhagen DISEASES database for BET1:Vestibular neuronitis Export disorders for BET1 gene to outside databases
|
Publications
for BET1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BET1 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with BET1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. (PubMed id 9382863)1, 2, 3 Zhang T....Hong W. (1997)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Membrane tethering in intracellular transport. (PubMed id 10449330)1, 3 Waters M.G. and Pfeffer S.R. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Linkage and association of successful aging to the 6q2 5 region in large Amish kindreds. (PubMed id 22773346)1 Edwards D.R....Scott W.K. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for BET1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BET1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BET1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BET1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BET1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BET1 gene:
Search GeneIP for patents involving BET1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BET1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BET1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BET1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BET1 | | | OriGene Protein Over-expression Lysate for BET1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BET1 | | OriGene 3'-UTR Clone for BET1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BET1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BET1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BET1 | | OriGene Custom Protein Services for BET1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BET1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BET1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BET1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BET1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BET1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BET1 |
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| | | | Search Tocris compounds for BET1 |
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 | | | BET1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BET1 |
|  |  |  | | | | Search ThermoFisher Antibodies for BET1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BET1 |
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