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Aliases for BET1 Gene

Aliases for BET1 Gene

  • Bet1 Golgi Vesicular Membrane Trafficking Protein 2 3 5
  • Golgi Vesicular Membrane Trafficking Protein P18 2 3
  • Golgi Vesicular Membrane-Trafficking Protein P18 3 4
  • Bet1p Homolog 2 3
  • HBET1 3 4
  • Blocked Early In Transport 1 Homolog (S. Cerevisiae) 2
  • Blocked Early In Transport 1 Homolog 3
  • Bet1 (S. Cerevisiae) Homolog 2
  • BET1 Homolog (S. Cerevisiae) 2
  • BET1 Homolog 3

External Ids for BET1 Gene

Previous GeneCards Identifiers for BET1 Gene

  • GC07M092157
  • GC07M093220
  • GC07M093234
  • GC07M093267
  • GC07M093430
  • GC07M093592
  • GC07M088228

Summaries for BET1 Gene

Entrez Gene Summary for BET1 Gene

  • This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for BET1 Gene

BET1 (Bet1 Golgi Vesicular Membrane Trafficking Protein) is a Protein Coding gene. Diseases associated with BET1 include Cecal Disease. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is BET1L.

UniProtKB/Swiss-Prot for BET1 Gene

  • Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).

Gene Wiki entry for BET1 Gene

Additional gene information for BET1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BET1 Gene

Genomics for BET1 Gene

Regulatory Elements for BET1 Gene

Enhancers for BET1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H094942 0.9 ENCODE 22.7 -938.1 -938138 0.6 FOXA2 ZFP64 ZBTB40 ZNF302 ZNF138 ZNF354C ZNF202 ZNF654 ZNF680 ZC3H11A RPS3AP25 CASD1 SGCE LOC105375403 BET1 COL1A2 DYNC1I1 PPP1R9A PIR34756 GC07M095019
GH07H094055 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -52.8 -52846 2.8 JUN MAFG CEBPB MAX EP300 ZBTB40 GABPA ZNF316 POLR2A FOS BET1 GNG11 TFPI2 LOC105375401 ENSG00000236938 ENSG00000236453
GH07H094049 1 Ensembl ENCODE 17.1 -45.8 -45768 1.4 PKNOX1 MAX EBF1 BATF RELA GATA3 POLR2A EED RUNX3 IKZF2 BET1 LOC105375401 TFPI2 GNG11 ENSG00000236453 ENSG00000236938
GH07H094059 1.3 FANTOM5 ENCODE dbSUPER 11.5 -56.0 -56034 2.2 CBFB ZBED1 NR2F1 CEBPB JUNB BATF BCL11A EED IKZF1 ETV6 BET1 GNG11 TFPI2 LOC105375401 ENSG00000236938 ENSG00000236453
GH07H093231 1.1 ENCODE 11.9 +772.3 772319 2 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 KRIT1 LOC105375403 PEX1 SAMD9L GATAD1 FAM133B BET1 VPS50 HEPACAM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BET1 on UCSC Golden Path with GeneCards custom track

Promoters for BET1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215216 190 2001 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 ZHX2 NFYC REST

Genomic Locations for BET1 Gene

Genomic Locations for BET1 Gene
chr7:93,962,762-94,004,390
(GRCh38/hg38)
Size:
41,629 bases
Orientation:
Minus strand
chr7:93,592,074-93,633,694
(GRCh37/hg19)

Genomic View for BET1 Gene

Genes around BET1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BET1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BET1 Gene

Proteins for BET1 Gene

  • Protein details for BET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15155-BET1_HUMAN
    Recommended name:
    BET1 homolog
    Protein Accession:
    O15155
    Secondary Accessions:
    • Q96EA0

    Protein attributes for BET1 Gene

    Size:
    118 amino acids
    Molecular mass:
    13289 Da
    Quaternary structure:
    • Interacts with STX17.

    Three dimensional structures from OCA and Proteopedia for BET1 Gene

    Alternative splice isoforms for BET1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BET1 Gene

Post-translational modifications for BET1 Gene

  • Ubiquitination at posLast=6262
  • Modification sites at PhosphoSitePlus

Other Protein References for BET1 Gene

No data available for DME Specific Peptides for BET1 Gene

Domains & Families for BET1 Gene

Gene Families for BET1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for BET1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15155

UniProtKB/Swiss-Prot:

BET1_HUMAN :
  • Belongs to the BET1 family.
Family:
  • Belongs to the BET1 family.
genes like me logo Genes that share domains with BET1: view

Function for BET1 Gene

Molecular function for BET1 Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).

Phenotypes From GWAS Catalog for BET1 Gene

Gene Ontology (GO) - Molecular Function for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with BET1: view
genes like me logo Genes that share phenotypes with BET1: view

miRNA for BET1 Gene

miRTarBase miRNAs that target BET1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BET1 Gene

Localization for BET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BET1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BET1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with BET1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BET1 Gene

Pathways & Interactions for BET1 Gene

genes like me logo Genes that share pathways with BET1: view

Gene Ontology (GO) - Biological Process for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with BET1: view

No data available for SIGNOR curated interactions for BET1 Gene

Drugs & Compounds for BET1 Gene

No Compound Related Data Available

Transcripts for BET1 Gene

Unigene Clusters for BET1 Gene

Bet1 golgi vesicular membrane trafficking protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BET1 Gene

No ASD Table

Relevant External Links for BET1 Gene

GeneLoc Exon Structure for
BET1
ECgene alternative splicing isoforms for
BET1

Expression for BET1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BET1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BET1 Gene

This gene is overexpressed in Bone (18.8), Placenta (13.6), and Breast (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BET1 Gene



Protein tissue co-expression partners for BET1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BET1 Gene:

BET1

SOURCE GeneReport for Unigene cluster for BET1 Gene:

Hs.489132

Evidence on tissue expression from TISSUES for BET1 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with BET1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BET1 Gene

Orthologs for BET1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BET1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia BET1 33
  • 94.63 (n)
cow
(Bos Taurus)
Mammalia BET1 33 34
  • 92.66 (n)
mouse
(Mus musculus)
Mammalia Bet1 33 16 34
  • 92.09 (n)
rat
(Rattus norvegicus)
Mammalia Bet1 33
  • 90.68 (n)
oppossum
(Monodelphis domestica)
Mammalia BET1 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves BET1 33 34
  • 78.55 (n)
lizard
(Anolis carolinensis)
Reptilia BET1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bet1 33
  • 76.04 (n)
Str.15246 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17630 33
zebrafish
(Danio rerio)
Actinopterygii bet1 33 34
  • 67.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012272 33
  • 47.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bet1 33 34
  • 45.48 (n)
worm
(Caenorhabditis elegans)
Secernentea nbet-1 34
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
Species where no ortholog for BET1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BET1 Gene

ENSEMBL:
Gene Tree for BET1 (if available)
TreeFam:
Gene Tree for BET1 (if available)

Paralogs for BET1 Gene

Paralogs for BET1 Gene

(2) SIMAP similar genes for BET1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for BET1 Gene

genes like me logo Genes that share paralogs with BET1: view

Variants for BET1 Gene

Sequence variations from dbSNP and Humsavar for BET1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000086272 -- 94,000,034(+) GGGCC(G/T)TAGTG intron-variant
rs1000090132 -- 93,962,927(+) AGACT(A/C/T)TTTAA nc-transcript-variant
rs1000331236 -- 93,990,618(+) GACAA(C/T)TCTTT intron-variant, upstream-variant-2KB
rs1000376574 -- 93,988,392(+) CTGGT(A/G)AAGAA intron-variant
rs1000438265 -- 93,965,961(+) GACTG(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BET1 Gene

Variant ID Type Subtype PubMed ID
nsv607849 CNV gain 21841781
nsv1023193 CNV gain 25217958
esv2540921 CNV deletion 19546169

Variation tolerance for BET1 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BET1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BET1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BET1 Gene

Disorders for BET1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BET1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cecal disease
  • disorder of cecum
- elite association - COSMIC cancer census association via MalaCards
Search BET1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BET1

Genetic Association Database (GAD)
BET1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BET1
genes like me logo Genes that share disorders with BET1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BET1 Gene

Publications for BET1 Gene

  1. The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. (PMID: 9382863) Zhang T … Hong W (The Journal of cell biology 1997) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  5. Membrane tethering in intracellular transport. (PMID: 10449330) Waters MG … Pfeffer SR (Current opinion in cell biology 1999) 2 3 60

Products for BET1 Gene

Sources for BET1 Gene

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