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Aliases for BET1 Gene

Aliases for BET1 Gene

  • Bet1 Golgi Vesicular Membrane Trafficking Protein 2 3
  • Golgi Vesicular Membrane Trafficking Protein P18 2 3
  • Golgi Vesicular Membrane-Trafficking Protein P18 3 4
  • Bet1p Homolog 2 3
  • HBET1 3 4
  • Blocked Early In Transport 1 Homolog (S. Cerevisiae) 2
  • Blocked Early In Transport 1 Homolog 3
  • Bet1 (S. Cerevisiae) Homolog 2
  • BET1 Homolog (S. Cerevisiae) 2
  • BET1 Homolog 3

External Ids for BET1 Gene

Summaries for BET1 Gene

Entrez Gene Summary for BET1 Gene

  • This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for BET1 Gene

BET1 (Bet1 Golgi Vesicular Membrane Trafficking Protein) is a Protein Coding gene. Diseases associated with BET1 include vestibular neuronitis and neuronitis. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. An important paralog of this gene is BET1L.

UniProtKB/Swiss-Prot for BET1 Gene

  • Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).

Gene Wiki entry for BET1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BET1 Gene

Genomics for BET1 Gene

Genomic Location for BET1 Gene

Start:
93,962,762 bp from pter
End:
94,004,382 bp from pter
Size:
41,621 bases
Orientation:
Minus strand

Genomic View for BET1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BET1 Gene

Regulatory Elements for BET1 Gene

Proteins for BET1 Gene

  • Protein details for BET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15155-BET1_HUMAN
    Recommended name:
    BET1 homolog
    Protein Accession:
    O15155
    Secondary Accessions:
    • Q96EA0

    Protein attributes for BET1 Gene

    Size:
    118 amino acids
    Molecular mass:
    13289 Da
    Quaternary structure:
    • Interacts with STX17.

    Three dimensional structures from OCA and Proteopedia for BET1 Gene

    Alternative splice isoforms for BET1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BET1 Gene

Proteomics data for BET1 Gene at MOPED

Post-translational modifications for BET1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys62

Other Protein References for BET1 Gene

No data available for DME Specific Peptides for BET1 Gene

Domains for BET1 Gene

Protein Domains for BET1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BET1_HUMAN
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.:
    • O15155
Family:
  • Belongs to the BET1 family.:
    • O15155
genes like me logo Genes that share domains with BET1: view

No data available for Gene Families for BET1 Gene

Function for BET1 Gene

Molecular function for BET1 Gene

UniProtKB/Swiss-Prot Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity).

Gene Ontology (GO) - Molecular Function for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with BET1: view

Phenotypes for BET1 Gene

GenomeRNAi human phenotypes for BET1:
genes like me logo Genes that share phenotypes with BET1: view

miRNA for BET1 Gene

miRTarBase miRNAs that target BET1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BET1 Gene

Localization for BET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BET1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BET1 Gene COMPARTMENTS Subcellular localization image for BET1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005801 cis-Golgi network IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BET1: view

Pathways for BET1 Gene

genes like me logo Genes that share pathways with BET1: view

Pathways by source for BET1 Gene

1 KEGG pathway for BET1 Gene

Gene Ontology (GO) - Biological Process for BET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IEA --
GO:0015031 protein transport IEA --
GO:0048280 vesicle fusion with Golgi apparatus IEA --
genes like me logo Genes that share ontologies with BET1: view

Transcripts for BET1 Gene

Unigene Clusters for BET1 Gene

Bet1 golgi vesicular membrane trafficking protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BET1 Gene

No ASD Table

Relevant External Links for BET1 Gene

GeneLoc Exon Structure for
BET1
ECgene alternative splicing isoforms for
BET1

Expression for BET1 Gene

mRNA expression in normal human tissues for BET1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BET1 Gene

SOURCE GeneReport for Unigene cluster for BET1 Gene Hs.489132

genes like me logo Genes that share expressions with BET1: view

Orthologs for BET1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BET1 36
  • 100 (n)
  • 100 (a)
BET1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BET1 36
  • 92.66 (n)
  • 95.76 (a)
BET1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BET1 36
  • 94.63 (n)
  • 97.46 (a)
mouse
(Mus musculus)
Mammalia Bet1 36
  • 92.09 (n)
  • 92.37 (a)
Bet1 16
Bet1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BET1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bet1 36
  • 90.68 (n)
  • 93.22 (a)
chicken
(Gallus gallus)
Aves BET1 36
  • 78.55 (n)
  • 80.87 (a)
BET1 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BET1 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17630 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730635 36
  • 76.04 (n)
  • 73.96 (a)
Str.15246 36
zebrafish
(Danio rerio)
Actinopterygii bet1 36
  • 67.55 (n)
  • 70.8 (a)
bet1 37
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012272 36
  • 47.57 (n)
  • 45.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bet1 36
  • 45.48 (n)
  • 40.19 (a)
Bet1 37
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nbet-1 37
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for BET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BET1 Gene

ENSEMBL:
Gene Tree for BET1 (if available)
TreeFam:
Gene Tree for BET1 (if available)

Paralogs for BET1 Gene

Paralogs for BET1 Gene

Selected SIMAP similar genes for BET1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for BET1 Gene

genes like me logo Genes that share paralogs with BET1: view

Variants for BET1 Gene

Sequence variations from dbSNP and Humsavar for BET1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs726820 -- 93,982,598(-) AGACA(C/T)GGAGA intron-variant
rs1008454 -- 93,973,820(+) CAACt(A/G)gaata intron-variant
rs1014424 -- 93,963,534(+) taatt(A/G)actac utr-variant-3-prime
rs1137271 -- 93,977,290(+) accct(A/G)tctct intron-variant
rs1476874 -- 93,991,153(+) TTCCA(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BET1 Gene

Variant ID Type Subtype PubMed ID
esv2540921 CNV Deletion 19546169

Relevant External Links for BET1 Gene

HapMap Linkage Disequilibrium report
BET1

Disorders for BET1 Gene

(1) University of Copenhagen DISEASES for BET1 Gene

Relevant External Links for BET1

Genetic Association Database (GAD)
BET1
genes like me logo Genes that share disorders with BET1: view

No data available for UniProtKB/Swiss-Prot for BET1 Gene

Publications for BET1 Gene

  1. The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. (PMID: 9382863) Zhang T. … Hong W. (J. Cell Biol. 1997) 2 3 4
  2. Membrane tethering in intracellular transport. (PMID: 10449330) Waters M.G. … Pfeffer S.R. (Curr. Opin. Cell Biol. 1999) 2 3
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for BET1 Gene

Sources for BET1 Gene

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