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BEST4 Gene

protein-coding   GIFtS: 50
GCID: GC01M045249

Bestrophin 4

(Previous name: vitelliform macular dystrophy 2-like 2)
(Previous symbol: VMD2L2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bestrophin 41 2
VMD2L21 2 3 5
Vitelliform Macular Dystrophy 2-Like 21 2
Vitelliform Macular Dystrophy 2-Like Protein 22 3
bestrophin-42

External Ids:    HGNC: 171061   Entrez Gene: 2666752   Ensembl: ENSG000001429597   OMIM: 6073365   UniProtKB: Q8NFU03   

Export aliases for BEST4 gene to outside databases

Previous GC identifers: GC01M045022 GC01M043362


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BEST4 Gene:
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene
structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane
proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif.
Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The
bestrophin 4 gene is predominantly expressed in the colon. (provided by RefSeq, Jul 2008)

GeneCards Summary for BEST4 Gene:
BEST4 (bestrophin 4) is a protein-coding gene. Diseases associated with BEST4 include patau syndrome, and macular dystrophy. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is BEST2.

UniProtKB/Swiss-Prot: BEST4_HUMAN, Q8NFU0
Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BEST4 gene promoter:
         GR   AP-1   ATF-2   Nkx2-5   c-Jun   GR-alpha   LyF-1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBEST4 promoter sequence
   Search Chromatin IP Primers for BEST4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BEST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32.3   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33-p32.3

BEST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEST4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045249:  view genomic region     (about GC identifiers)

Start:
45,249,257 bp from pter      End:
45,253,426 bp from pter
Size:
4,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BEST4_HUMAN, Q8NFU0 (See protein sequence)
Recommended Name: Bestrophin-4  
Size: 473 amino acids; 53497 Da
Secondary accessions: Q5JR93

Explore the universe of human proteins at neXtProt for BEST4: NX_Q8NFU0

Explore proteomics data for BEST4 at MOPED


See BEST4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_695006.1  
ENSEMBL proteins: 
 ENSP00000361281  
Reactome Protein details: Q8NFU0

BEST4 Human Recombinant Protein Products:

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BEST4 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BEST: Ion channels / Chloride channels : Calcium activated : Bestrophins

2 InterPro protein domains:
 IPR000615 Bestrophin
 IPR021134 Bestrophin/UPF0187

Graphical View of Domain Structure for InterPro Entry Q8NFU0

ProtoNet protein and cluster: Q8NFU0

1 Blocks protein domain: IPB000615 Putative membrane protein

UniProtKB/Swiss-Prot: BEST4_HUMAN, Q8NFU0
Similarity: Belongs to the bestrophin family


BEST4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: BEST4_HUMAN, Q8NFU0
Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005254chloride channel activity IEA--
     
BEST4 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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1 qRT-PCR Assays for microRNA that regulate BEST4:
hsa-miR-361-3p
SwitchGear 3'UTR luciferase reporter plasmidBEST4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for BEST4
Predesigned siRNA for gene silencing in human, mouse, rat BEST4

Gene Editing
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DNA2.0 Custom Protein Engineering Service for BEST4

Clone
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OriGene clones in human, mouse for BEST4 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: BEST4 (NM_153274)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEST4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEST4

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEST4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
BEST4_HUMAN, Q8NFU0: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
extracellular1
lysosome1
mitochondrion1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0034707chloride channel complex IEA--

BEST4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for BEST4 About    
See pathways by source

SuperPathContained pathways About
1Ion channel transport
Ion channel transport0.58
Stimuli-sensing channels0.58
2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for BEST4
    Stimuli-sensing channels



BEST4 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BEST4
Interactions:

    Search GeneGlobe Interaction Network for BEST4

1 Interacting protein for BEST4 (Q8NFU02) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
--P310162MINT-8106273
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

BEST4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for BEST4

3 HMDB Compounds for BEST4    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
ChlorineCl2 (see all 13)16887-00-6--
Hydrogen carbonateBicarbonate (see all 19)71-52-3--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for BEST4 gene: 
NM_153274.2  

Unigene Cluster for BEST4:

Bestrophin 4
Hs.302513  [show with all ESTs]
Unigene Representative Sequence: NM_153274
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000372207(uc001cmm.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat BEST4 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate BEST4:
hsa-miR-361-3p
SwitchGear 3'UTR luciferase reporter plasmidBEST4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for BEST4
Predesigned siRNA for gene silencing in human, mouse, rat BEST4
Clone
Products:
     
OriGene clones in human, mouse for BEST4 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: BEST4 (NM_153274)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEST4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEST4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for BEST4
OriGene qSTAR qPCR primer pairs in human, mouse for BEST4
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BEST4
  QuantiTect SYBR Green Assays in human, mouse, rat BEST4
  QuantiFast Probe-based Assays in human, mouse, rat BEST4

Additional mRNA sequence: 

AF440757.1 AY515707.1 BC101823.1 

2 DOTS entries:

DT.97811122  DT.95090366 

18 AceView cDNA sequences:

BM982532 BM142500 BM142321 CK820250 AF440757 AY515707 CK820249 BI762068 
NM_153274 AW084499 BM717327 BQ028310 AV695179 BG979926 AW117683 AI307756 
BF799085 BF799082 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BEST4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAAACGTGC
BEST4 Expression
About this image

BEST4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

BEST4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.302513

UniProtKB/Swiss-Prot: BEST4_HUMAN, Q8NFU0
Tissue specificity: Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung,
trachea, testis and placenta

    Custom PCR Arrays for BEST4
Primer
Products:
OriGene qPCR primer pairs and template standards for BEST4
OriGene qSTAR qPCR primer pairs in human, mouse for BEST4
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BEST4
QuantiTect SYBR Green Assays in human, mouse, rat BEST4
QuantiFast Probe-based Assays in human, mouse, rat BEST4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEST4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for BEST4 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Best4-ps5 bestrophin 4, pseudogene   --   4 (53.41 cM) 117145257 
chicken
(Gallus gallus)
Aves BEST41 bestrophin 4 77.98(n)
78.51(a)
  771694  NM_001252125.1  NP_001239054.1 
lizard
(Anolis carolinensis)
Reptilia BEST46
bestrophin 4
68(a)
1 ↔ 1
4(111016468-111053580)
tropical clawed frog
(Xenopus tropicalis)
Amphibia best41 bestrophin 4 66.44(n)
71.59(a)
  100144681  NM_001123442.1  NP_001116914.1 
zebrafish
(Danio rerio)
Actinopterygii best41 bestrophin 4 65.85(n)
67.48(a)
  563711  XM_687068.3  XP_692160.3 
fruit fly
(Drosophila melanogaster)
Insecta Best41 Bestrophin 4 54.18(n)
51.01(a)
  39660  NM_001104139.2  NP_001097609.1 
worm
(Caenorhabditis elegans)
Secernentea best-236
best-26
(see all 27)
Protein BEST-2 (best-2) mRNA, complete cds
(see all 27)
37(a)
34(a)
(see all 27)
many ↔ many
many ↔ many
(see all 27)
II(7904638-7907589) WBGene00014989
IV(13111520-13113082) WBGene00007204


ENSEMBL Gene Tree for BEST4 (if available)
TreeFam Gene Tree for BEST4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for BEST4 gene
BEST22  BEST12  BEST32  
3 SIMAP similar genes for BEST4 using alignment to 1 protein entry:     BEST4_HUMAN:
BEST3    BEST2    BEST1

BEST4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for BEST4 (see all 164)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs120940281,2
C,F,A--45248869(+) GGATCC/TGCCCA 1 -- ds50018Minor allele frequency- T:0.46NA WA CSA 13
rs45422481,2
C,F,A--45248922(+) GTGCCC/GAGCCA 1 -- ds500110Minor allele frequency- G:0.47NA WA CSA EA 372
rs1881835371,2
--45249009(+) CCCGTA/TAACTG 1 -- ds50010--------
rs2008824171,2
--45249059(+) CTTGG-/CACACAC 1 -- ds50010--------
rs2019982431,2
C--45249063(+) GGCACA/TCAAGT 1 -- ds50010--------
rs341141721,2
C--45249064(+) CACACTG/-AAGTC 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
rs667534651,2
C--45249065(+) ACACA-/TGAGTCC 1 -- ds50010--------
rs1917652491,2
--45249293(+) AAACAA/GAAACT 1 -- ut310--------
rs779825861,2
C,F--45249492(+) TAACGT/AGCCAG 1 -- ut311Minor allele frequency- A:0.02NA 120
rs1432367341,2
C--45249805(+) TAATAC/GAGCTG 1 -- ut310--------

HapMap Linkage Disequilibrium report for BEST4 (45249257 - 45253426 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for BEST4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv870815CNV Loss21882294
nsv461406CNV Loss19166990

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing BEST4
DNA2.0 Custom Variant and Variant Library Synthesis for BEST4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607336    OMIM disorders: --

4 diseases for BEST4:    
About MalaCards
patau syndrome    macular dystrophy    vitelliform macular dystrophy    pancreatitis

1 disease from the University of Copenhagen DISEASES database for BEST4:
Vitelliform macular dystrophy

BEST4 for disorders           About GeneDecksing


Export disorders for BEST4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for BEST4 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with BEST4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. (PubMed id 12032738)1, 2, 3 Stoehr H.... Weber B.H.F. (Eur. J. Hum. Genet. 2002)
  2. Ca2+-activated Cl- current from human bestrophin-4 in excised membrane patches. (PubMed id 16702355)1, 3 Tsunenari T....Yau K.W. (J. Gen. Physiol. 2006)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Structure-function analysis of the bestrophin family of anion channels. (PubMed id 12907679)1, 2 Tsunenari T....Nathans J. (J. Biol. Chem. 2003)
  6. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
  7. Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1. (PubMed id 19237432)1 Marsey L.L. and Winpenny J.P. (J. Physiol. (Lond.) 2009)
  8. Bestrophin Cl- channels are highly permeable to HCO3-. (PubMed id 18400985)2 Qu Z. and Hartzell H.C. (Am. J. Physiol. 2008)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease). (PubMed id 9700209)1 Marquardt A....Weber B.H.F. (Hum. Mol. Genet. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 266675 HGNC: 17106 AceView: VMD2L2 Ensembl:ENSG00000142959 euGenes: HUgn266675
ECgene: BEST4 H-InvDB: BEST4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BEST4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BEST4 gene:
Search GeneIP for patents involving BEST4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene Antibodies for BEST4   OriGene RNAi products in human, mouse, rat for BEST4  
 OriGene qPCR primer pairs and template standards for BEST4   Browse OriGene Protein Over-expression Lysates  
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 Custom PCR Arrays for BEST4 Search Chromatin IP Primers for BEST4
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 Browse ESI BIO Cell Lines and PureStem Progenitors for BEST4
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BEST4
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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