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BEST3 Gene

protein-coding   GIFtS: 53
GCID: GC12M070037

Bestrophin 3

(Previous name: vitelliform macular dystrophy 2-like 3)
(Previous symbol: VMD2L3)
  See BEST3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bestrophin 31 2
VMD2L31 2 3 5
Vitelliform Macular Dystrophy 2-Like 31 2
Vitelliform Macular Dystrophy 2-Like Protein 32 3
bestrophin-32

External Ids:    HGNC: 171051   Entrez Gene: 1444532   Ensembl: ENSG000001273257   OMIM: 6073375   UniProtKB: Q8N1M13   

Export aliases for BEST3 gene to outside databases

Previous GC identifers: GC12M068326 GC12M067096


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BEST3 Gene:
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in
vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM
607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of
aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene
structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron
boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002
(PubMed 12032738); Tsunenari et al., 2003 (PubMed 12907679)).(supplied by OMIM, Mar 2008)

GeneCards Summary for BEST3 Gene:
BEST3 (bestrophin 3) is a protein-coding gene. Diseases associated with BEST3 include vitelliform macular dystrophy. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is BEST2.

UniProtKB/Swiss-Prot: BEST3_HUMAN, Q8N1M1
Function: Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BEST3 gene promoter:
         MEF-2A   USF1   USF-1   Lmo2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BEST3 promoter sequence
   Search Chromatin IP Primers for BEST3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BEST3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.2-q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q14.2-q15

BEST3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEST3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M070037:  view genomic region     (about GC identifiers)

Start:
70,037,140 bp from pter      End:
70,093,256 bp from pter
Size:
56,117 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BEST3_HUMAN, Q8N1M1 (See protein sequence)
Recommended Name: Bestrophin-3  
Size: 668 amino acids; 76107 Da
Secondary accessions: B5MDI8 Q53YQ7 Q8N356 Q8NFT9 Q9BR80
Alternative splicing: 4 isoforms:  Q8N1M1-2   Q8N1M1-1   Q8N1M1-4   Q8N1M1-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for BEST3: NX_Q8N1M1

Explore proteomics data for BEST3 at MOPED


See BEST3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts): 
NP_001269542.1  NP_001269543.1  NP_001269544.1  NP_001269545.1  NP_116124.2  NP_689652.2  

ENSEMBL proteins: 
 ENSP00000449868   ENSP00000329064   ENSP00000433213   ENSP00000332413   ENSP00000449548  
 ENSP00000434713   ENSP00000447689   ENSP00000446575   ENSP00000266661   ENSP00000449377  
 ENSP00000377032  
Reactome Protein details: Q8N1M1

BEST3 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for BEST3

 
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antibodies-online proteins for BEST3 (3 products) 

 
antibodies-online peptides for BEST3

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antibodies-online antibodies for BEST3 (56 products) 

BEST3 Assay Products:

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antibodies-online kits for BEST3 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BEST: Ion channels / Chloride channels : Calcium activated : Bestrophins

2 InterPro protein domains:
 IPR000615 Bestrophin
 IPR021134 Bestrophin/UPF0187

Graphical View of Domain Structure for InterPro Entry Q8N1M1

ProtoNet protein and cluster: Q8N1M1

1 Blocks protein domain: IPB000615 Putative membrane protein

UniProtKB/Swiss-Prot: BEST3_HUMAN, Q8N1M1
Similarity: Belongs to the bestrophin family


Find genes that share domains with BEST3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: BEST3_HUMAN, Q8N1M1
Function: Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005254chloride channel activity IEA--
     
Find genes that share ontologies with BEST3           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for BEST3

miRNA
Products:
    
miRTarBase miRNAs that target BEST3:
hsa-mir-196b-5p (MIRT042669)

Block miRNA regulation of human, mouse, rat BEST3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate BEST3 (see all 9):
hsa-miR-582-3p hsa-miR-365 hsa-miR-562 hsa-miR-218-1* hsa-miR-4267 hsa-miR-21 hsa-miR-590-5p hsa-miR-659
SwitchGear 3'UTR luciferase reporter plasmidBEST3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for BEST3
Predesigned siRNA for gene silencing in human, mouse, rat BEST3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for BEST3

Clone
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OriGene clones in human, mouse for BEST3 (see all 13)
OriGene ORF clones in mouse, rat for BEST3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): BEST3 (NM_152439)
Sino Biological Human cDNA Clone for BEST3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEST3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEST3

Cell Line
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GenScript Custom overexpressing Cell Line Services for BEST3
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEST3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
BEST3_HUMAN, Q8N1M1: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
golgi apparatus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0034707chloride channel complex IEA--

Find genes that share ontologies with BEST3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for BEST3 About    
See pathways by source

SuperPathContained pathways About
1Ion channel transport
Ion channel transport0.58
Stimuli-sensing channels0.58
2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47


Find genes that share SuperPaths with BEST3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for BEST3
    Stimuli-sensing channels


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BEST3
Interactions:

    Search GeneGlobe Interaction Network for BEST3

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--
GO:0015698inorganic anion transport ----
GO:0043271negative regulation of ion transport IEA--

Find genes that share ontologies with BEST3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for BEST3

3 HMDB Compounds for BEST3    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
ChlorineCl2 (see all 13)16887-00-6--
Hydrogen carbonateBicarbonate (see all 19)71-52-3--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for BEST3 gene (6 alternative transcripts): 
NM_001282613.1  NM_001282614.1  NM_001282615.1  NM_001282616.1  NM_032735.2  NM_152439.3  

Unigene Cluster for BEST3:

Bestrophin 3
Hs.280782  [show with all ESTs]
Unigene Representative Sequence: NM_032735
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000547208 ENST00000331471(uc001svd.2) ENST00000488961(uc001svf.3)
ENST00000330891(uc001svg.3 uc010stm.2) ENST00000553096 ENST00000476098
ENST00000552295 ENST00000548658 ENST00000266661(uc001svi.1) ENST00000529843
ENST00000551160 ENST00000533674 ENST00000393365
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat BEST3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate BEST3 (see all 9):
hsa-miR-582-3p hsa-miR-365 hsa-miR-562 hsa-miR-218-1* hsa-miR-4267 hsa-miR-21 hsa-miR-590-5p hsa-miR-659
SwitchGear 3'UTR luciferase reporter plasmidBEST3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for BEST3
Predesigned siRNA for gene silencing in human, mouse, rat BEST3
Clone
Products:
     
OriGene clones in human, mouse for BEST3 (see all 13)
OriGene ORF clones in mouse, rat for BEST3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): BEST3 (NM_152439)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEST3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEST3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for BEST3
OriGene qSTAR qPCR primer pairs in human, mouse for BEST3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BEST3
  QuantiTect SYBR Green Assays in human, mouse, rat BEST3
  QuantiFast Probe-based Assays in human, mouse, rat BEST3

Additional mRNA sequence: 

AF440758.1 AK096459.1 AY515706.1 BC006440.1 BC028087.1 BC151138.1 

8 DOTS entries:

DT.95258888  DT.206522  DT.95328575  DT.75182139  DT.100831916  DT.121184315  DT.121184318  DT.302823 

Selected AceView cDNA sequences (see all 52):

BQ955380 AI268770 CR614874 AY515706 AF440758 AI302692 AA992681 AK096459 
CR612373 AW612705 AV757060 AI681290 AI692649 AI800728 AI052096 BE267947 
BE219263 NM_152439 AL598355 AW674562 BE245306 AA777061 BC006440 AA953908 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for BEST3 (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1:                                                        -     -     -     -                                               -     -               
SP2:                                                        -     -     -     -                                                                     
SP3:                                                              -     -     -                       -                                             
SP4:                          -     -                 -     -     -     -     -                       -                                             
SP5:                                                                                                  -           -           -     -               


ECgene alternative splicing isoforms for BEST3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BEST3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATTTCAAAA
BEST3 Expression
About this image


BEST3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Small Pre B-Cells Hematopoietic Bone Marrow
BEST3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

BEST3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.280782

UniProtKB/Swiss-Prot: BEST3_HUMAN, Q8N1M1
Tissue specificity: Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina

    Custom PCR Arrays for BEST3
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QuantiFast Probe-based Assays in human, mouse, rat BEST3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEST3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for BEST3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Best31 , 5 bestrophin 31, 5 83.87(n)1
86.41(a)1
  10 (65.00 cM)5
3824271  NM_001007583.11  NP_001007584.11 
 1169863145 
chicken
(Gallus gallus)
Aves BEST31 bestrophin 3 66.67(n)
66(a)
  417849  NM_001199669.1  NP_001186598.1 
lizard
(Anolis carolinensis)
Reptilia BEST36
bestrophin 3
61(a)
1 ↔ 1
GL343256.1(1673716-1705714)
tropical clawed frog
(Xenopus tropicalis)
Amphibia best31 bestrophin 3 64.03(n)
65.72(a)
  100302039  NM_001161752.1  NP_001155224.1 
fruit fly
(Drosophila melanogaster)
Insecta Best31 Bestrophin 3 52.37(n)
46.17(a)
  39661  NM_168618.2  NP_730039.1 
worm
(Caenorhabditis elegans)
Secernentea best-236
best-146
(see all 27)
Protein BEST-14 (best-14) mRNA, complete cds
(see all 27)
36(a)
35(a)
(see all 27)
many ↔ many
many ↔ many
(see all 27)
II(7904638-7907589) WBGene00014989
V(10557976-10560792) WBGene00009340


ENSEMBL Gene Tree for BEST3 (if available)
TreeFam Gene Tree for BEST3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for BEST3 gene
BEST22  BEST42  BEST12  
3 SIMAP similar genes for BEST3 using alignment to 6 protein entries:     BEST3_HUMAN (see all proteins):
BEST2    BEST4    BEST1

Find genes that share paralogs with BEST3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for BEST3 (see all 1089)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs72971151,2
C,F,H--67144580(+) CCTTGC/AACCTT 1 -- us2k15Minor allele frequency- A:0.01NS EA NA 540
rs666246471,2
C--69906163(-) TCTCC-/A/AA  
        
AAAAA
2 -- int12NA 4
rs1916877661,2
--70046931(+) GAGGGA/TCCTGC 2 -- ds50010--------
rs1848311801,2
--70047019(+) GCATAA/GAAGAC 2 -- ds50010--------
rs19797151,2
C,F,A,H--70047028(-) TCTACC/GTGCGT 2 -- ds500120Minor allele frequency- G:0.22NS EA NA WA CSA 1342
rs1901702191,2
--70047034(+) GTAGAA/CTTGAG 2 -- ds50010--------
rs1818181491,2
--70047296(+) CTAAAA/GCCTGT 2 -- ds50010--------
rs111777731,2
C,F,H--70047351(+) agattC/TGCTGC 2 -- ds500122Minor allele frequency- T:0.13NS EA NA CSA WA 2098
rs21614381,2
C,F--70047362(-) TGTTCC/TAGGCA 2 -- ds500110Minor allele frequency- T:0.17NA WA CSA EA 504
rs1873750241,2
C--70047370(+) ACAGTA/GTAAGC 2 -- ds50010--------

HapMap Linkage Disequilibrium report for BEST3 (70037140 - 70093256 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for BEST3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2667241CNV Deletion23128226
esv2746019CNV Deletion23290073
nsv507651CNV Insertion20534489
nsv899229CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing BEST3
DNA2.0 Custom Variant and Variant Library Synthesis for BEST3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607337    OMIM disorders: --

1 disease for BEST3:    
About MalaCards
vitelliform macular dystrophy

1 disease from the University of Copenhagen DISEASES database for BEST3:
Vitelliform macular dystrophy

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Genetic Association Database (GAD): BEST3

Export disorders for BEST3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for BEST3 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with BEST3)
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  1. Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. (PubMed id 12032738)1, 2, 3 Stoehr H.... Weber B.H.F. (Eur. J. Hum. Genet. 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Structure-function analysis of the bestrophin family of anion channels. (PubMed id 12907679)1, 2 Tsunenari T....Nathans J. (J. Biol. Chem. 2003)
  5. Activation of bestrophin Cl- channels is regulated by C-terminal domains. (PubMed id 17442670)1, 9 Qu Z.Q....Hartzell C. (J. Biol. Chem. 2007)
  6. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. (PubMed id 22863734)1 Ludwig K.U....NAPthen M.M. (Nat. Genet. 2012)
  7. Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1. (PubMed id 19237432)1 Marsey L.L. and Winpenny J.P. (J. Physiol. (Lond.) 2009)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 144453 HGNC: 17105 AceView: MGC13168 Ensembl:ENSG00000127325 euGenes: HUgn144453
ECgene: BEST3 H-InvDB: BEST3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BEST3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BEST3 gene:
Search GeneIP for patents involving BEST3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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