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BEST2 Gene

protein-coding   GIFtS: 49
GCID: GC19P012864

Bestrophin 2

(Previous name: vitelliform macular dystrophy 2-like 1)
(Previous symbol: VMD2L1)
  See BEST2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bestrophin 21 2
VMD2L11 2 3 5
Vitelliform Macular Dystrophy 2-Like 11 2
Vitelliform Macular Dystrophy 2-Like Protein 12 3
bestrophin-22
VMD2-Like Gene 12

External Ids:    HGNC: 171071   Entrez Gene: 548312   Ensembl: ENSG000000399877   OMIM: 6073355   UniProtKB: Q8NFU13   

Export aliases for BEST2 gene to outside databases

Previous GC identifers: GC19P012725 GC19P012436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BEST2 Gene:
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene
structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane
proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif.
Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The
bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. (provided by RefSeq, Jul 2008)

GeneCards Summary for BEST2 Gene:
BEST2 (bestrophin 2) is a protein-coding gene. Diseases associated with BEST2 include bestrophinopathy, and vitelliform macular dystrophy. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is BEST4.

UniProtKB/Swiss-Prot: BEST2_HUMAN, Q8NFU1
Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate

Gene Wiki entry for BEST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BEST2 gene promoter:
         Pax-5   Sp1   GCNF   Pax-6   AP-2gamma   Tal-1beta   GCNF-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBEST2 promoter sequence
   Search Chromatin IP Primers for BEST2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BEST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2-p13.12

BEST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEST2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012864:  view genomic region     (about GC identifiers)

Start:
12,862,516 bp from pter      End:
12,869,272 bp from pter
Size:
6,757 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BEST2_HUMAN, Q8NFU1 (See protein sequence)
Recommended Name: Bestrophin-2  
Size: 509 amino acids; 57139 Da
Sequence caution: Sequence=BAA90970.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53YQ8 Q9NXP0

Explore the universe of human proteins at neXtProt for BEST2: NX_Q8NFU1

Explore proteomics data for BEST2 at MOPED


See BEST2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060152.2  
ENSEMBL proteins: 
 ENSP00000448310   ENSP00000447203   ENSP00000449403   ENSP00000042931  
Reactome Protein details: Q8NFU1

BEST2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for BEST2

 
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BEST2 Antibody Products:

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BEST2 Assay Products:

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Cloud-Clone Corp. ELISAs for BEST2
Cloud-Clone Corp. CLIAs for BEST2
Search eBioscience for ELISAs for BEST2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BEST: Ion channels / Chloride channels : Calcium activated : Bestrophins

2 InterPro protein domains:
 IPR000615 Bestrophin
 IPR021134 Bestrophin/UPF0187

Graphical View of Domain Structure for InterPro Entry Q8NFU1

ProtoNet protein and cluster: Q8NFU1

1 Blocks protein domain: IPB000615 Putative membrane protein

UniProtKB/Swiss-Prot: BEST2_HUMAN, Q8NFU1
Similarity: Belongs to the bestrophin family


Find genes that share domains with BEST2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: BEST2_HUMAN, Q8NFU1
Function: Forms calcium-sensitive chloride channels. Permeable to bicarbonate

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005254contributes to chloride channel activity ISS--
     
Find genes that share ontologies with BEST2           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Best2):
 digestive/alimentary  homeostasis/metabolism  taste/olfaction  vision/eye 

Find genes that share phenotypes with BEST2           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BEST2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BEST2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BEST2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BEST2

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat BEST2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for BEST2

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OriGene ORF clones in mouse, rat for BEST2
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GenScript: all cDNA clones in your preferred vector: BEST2 (NM_017682)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEST2
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BEST2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEST2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
BEST2_HUMAN, Q8NFU1: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
mitochondrion2
cytosol1
lysosome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0005929cilium ISS--
GO:0034707chloride channel complex IEA--

Find genes that share ontologies with BEST2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for BEST2 About    
See pathways by source

SuperPathContained pathways About
1Ion channel transport
Ion channel transport0.58
Stimuli-sensing channels0.58
2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47
3Salivary secretion
Salivary secretion0.34


Find genes that share SuperPaths with BEST2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for BEST2
    Stimuli-sensing channels


1 Kegg Pathway  (Kegg details for BEST2):
    Salivary secretion

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BEST2
Interactions:

    Search GeneGlobe Interaction Network for BEST2

1 Interacting protein for BEST2 (Q8NFU13) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DNASE2O001153I2D: score=1 
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006821chloride transport ----
GO:0007608sensory perception of smell ISS--
GO:0008150biological_process ND--
GO:0051899membrane depolarization ISS--
GO:1902476chloride transmembrane transport ISS--

Find genes that share ontologies with BEST2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for BEST2

3 HMDB Compounds for BEST2    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
ChlorineCl2 (see all 13)16887-00-6--
Hydrogen carbonateBicarbonate (see all 19)71-52-3--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for BEST2 gene: 
NM_017682.2  

Unigene Cluster for BEST2:

Bestrophin 2
Hs.435611  [show with all ESTs]
Unigene Representative Sequence: NM_017682
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000549706 ENST00000553030(uc002mux.3) ENST00000552539 ENST00000042931

miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate BEST2
SwitchGear 3'UTR luciferase reporter plasmidBEST2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for BEST2
Predesigned siRNA for gene silencing in human, mouse, rat BEST2
Clone
Products:
     
OriGene clones in human, mouse for BEST2 (see all 6)
OriGene ORF clones in mouse, rat for BEST2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: BEST2 (NM_017682)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEST2
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BEST2
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BEST2
  QuantiTect SYBR Green Assays in human, mouse, rat BEST2
  QuantiFast Probe-based Assays in human, mouse, rat BEST2

Additional mRNA sequence: 

AF440756.1 AK000139.1 AK225232.1 AY515705.1 

1 DOTS entry:

DT.435655 

8 AceView cDNA sequences:

AF440756 BX107640 CD671941 AY515705 NM_017682 AK000139 AA573517 AA621745 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BEST2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGATGAAAG
BEST2 Expression
About this image

BEST2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

BEST2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.435611

UniProtKB/Swiss-Prot: BEST2_HUMAN, Q8NFU1
Tissue specificity: Mainly confined to the retinal pigment epithelium and colon

    Custom PCR Arrays for BEST2
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QuantiFast Probe-based Assays in human, mouse, rat BEST2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEST2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for BEST2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Best21 , 5 bestrophin 21, 5 83.04(n)1
89.94(a)1
  8 (41.46 cM)5
2129891  NM_001130194.11  NP_001123666.11 
 850072025 
lizard
(Anolis carolinensis)
Reptilia BEST26
bestrophin 2
63(a)
1 ↔ 1
GL343286.1(870158-891135)
African clawed frog
(Xenopus laevis)
Amphibia MGC536802 similar to vitelliform macular dystrophy 2-like protein more 77.91(n)    BC043854.1 
zebrafish
(Danio rerio)
Actinopterygii best21 bestrophin 2 69.41(n)
70.6(a)
  567214  XM_690505.2  XP_695597.1 
fruit fly
(Drosophila melanogaster)
Insecta Best11 Bestrophin 1 57.93(n)
54.32(a)
  53431  NM_144346.4  NP_652603.1 
worm
(Caenorhabditis elegans)
Secernentea best-231 best-23 45.29(n)
39.39(a)
  6418643  NM_001129196.2  NP_001122668.1 


ENSEMBL Gene Tree for BEST2 (if available)
TreeFam Gene Tree for BEST2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for BEST2 gene
BEST42  BEST12  BEST32  
3 SIMAP similar genes for BEST2 using alignment to 2 protein entries:     BEST2_HUMAN (see all proteins):
BEST3    BEST1    BEST4

Find genes that share paralogs with BEST2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for BEST2 (see all 211)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1890496491,2
--12861460(+) GACAAA/GGTTTT 1 -- us2k10--------
rs1458403341,2
--12861552(+) GGAGCA/GTTGGA 1 -- us2k10--------
rs1153454451,2
C,F--12861580(+) ATATTG/AGTGTA 1 -- us2k11Minor allele frequency- A:0.04WA 118
rs1915923471,2
--12861685(+) GGCCCC/TGCTCT 1 -- us2k10--------
rs1821784871,2
C--12861700(+) CTGGGA/TTTGTG 1 -- us2k10--------
rs1384116581,2
--12861703(+) GGATTG/TTGTGC 1 -- us2k10--------
rs1872908011,2
--12861713(+) CCACCA/GCACTG 1 -- us2k10--------
rs1176327451,2
C,F--12861842(+) GGGTGG/AGGTCT 1 -- us2k11Minor allele frequency- A:0.02NA 120
rs795916791,2
F--12861854(+) GCACTT/GGGCTG 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs1416677941,2
--12861869(+) TGTGGC/GTGTCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for BEST2 (12862516 - 12869272 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for BEST2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv911077CNV Loss21882294
nsv911079CNV Loss21882294
dgv3733n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing BEST2
DNA2.0 Custom Variant and Variant Library Synthesis for BEST2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607335    OMIM disorders: --

2 diseases for BEST2:    
About MalaCards
bestrophinopathy    vitelliform macular dystrophy

2 diseases from the University of Copenhagen DISEASES database for BEST2:
Vitelliform macular dystrophy     Bestrophinopathy

Find genes that share disorders with BEST2           About GenesLikeMe


Export disorders for BEST2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for BEST2 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with BEST2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. (PubMed id 12032738)1, 2, 3 Stoehr H.... Weber B.H.F. (Eur. J. Hum. Genet. 2002)
  2. Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction. (PubMed id 16912113)1, 3 Pifferi S....Zucchelli S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Structure-function analysis of the bestrophin family of anion channels. (PubMed id 12907679)1, 2 Tsunenari T....Nathans J. (J. Biol. Chem. 2003)
  5. The vitelliform macular dystrophy protein defines a new family of chloride channels. (PubMed id 11904445)1, 2 Sun H.... Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium. (PubMed id 20157619)1, 9 Zhang Y....Marmorstein A.D. (Mol. Vis. 2010)
  7. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
  8. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. (PubMed id 20407206)1 Yu K....Hartzell H.C. (J. Clin. Invest. 2010)
  9. Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1. (PubMed id 19237432)1 Marsey L.L. and Winpenny J.P. (J. Physiol. (Lond.) 2009)
  10. Functional roles of bestrophins in ocular epithelia. (PubMed id 19398034)1 Marmorstein A.D....Peachey N.S. (Prog Retin Eye Res 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54831 HGNC: 17107 AceView: VMD2L1 Ensembl:ENSG00000039987 euGenes: HUgn54831
ECgene: BEST2 Kegg: 54831 H-InvDB: BEST2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BEST2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BEST2 gene:
Search GeneIP for patents involving BEST2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Block miRNA regulation of human, mouse, rat BEST2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BEST2
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