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Aliases for BEND6 Gene

Aliases for BEND6 Gene

  • BEN Domain Containing 6 2 3 5
  • C6orf65 3 4
  • Chromosome 6 Open Reading Frame 65 2

External Ids for BEND6 Gene

Previous HGNC Symbols for BEND6 Gene

  • C6orf65

Previous GeneCards Identifiers for BEND6 Gene

  • GC06P056927
  • GC06P056819
  • GC06P056653

Summaries for BEND6 Gene

GeneCards Summary for BEND6 Gene

BEND6 (BEN Domain Containing 6) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathways. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity.

UniProtKB/Swiss-Prot for BEND6 Gene

  • Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND6 Gene

Genomics for BEND6 Gene

Regulatory Elements for BEND6 Gene

Enhancers for BEND6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BEND6 on UCSC Golden Path with GeneCards custom track

Promoters for BEND6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BEND6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEND6 Gene

56,954,975 bp from pter
57,027,652 bp from pter
72,678 bases
Plus strand

Genomic View for BEND6 Gene

Genes around BEND6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND6 Gene

Proteins for BEND6 Gene

  • Protein details for BEND6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BEN domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q4G0W8
    • Q8N662
    • Q96NS6

    Protein attributes for BEND6 Gene

    279 amino acids
    Molecular mass:
    31222 Da
    Quaternary structure:
    • Interacts (via BEN domain) with RBPJ.

    Alternative splice isoforms for BEND6 Gene


neXtProt entry for BEND6 Gene

Proteomics data for BEND6 Gene at MOPED

Post-translational modifications for BEND6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND6 Gene

No data available for DME Specific Peptides for BEND6 Gene

Domains & Families for BEND6 Gene

Gene Families for BEND6 Gene

Protein Domains for BEND6 Gene


Suggested Antigen Peptide Sequences for BEND6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BEN domain.
  • Contains 1 BEN domain.
genes like me logo Genes that share domains with BEND6: view

Function for BEND6 Gene

Molecular function for BEND6 Gene

UniProtKB/Swiss-Prot Function:
Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).
genes like me logo Genes that share phenotypes with BEND6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEND6 Gene

Localization for BEND6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEND6 Gene

Subcellular locations from

Jensen Localization Image for BEND6 Gene COMPARTMENTS Subcellular localization image for BEND6 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for BEND6 Gene

Pathways & Interactions for BEND6 Gene

SuperPathways for BEND6 Gene

Superpath Contained pathways
1 Notch Signaling Pathways
genes like me logo Genes that share pathways with BEND6: view

Pathways by source for BEND6 Gene

1 R&D Systems pathway for BEND6 Gene

Interacting Proteins for BEND6 Gene

Gene Ontology (GO) - Biological Process for BEND6 Gene


No data available for SIGNOR curated interactions for BEND6 Gene

Drugs & Compounds for BEND6 Gene

No Compound Related Data Available

Transcripts for BEND6 Gene

Unigene Clusters for BEND6 Gene

BEN domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEND6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP2: - - -
SP3: - - -

Relevant External Links for BEND6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEND6 Gene

mRNA expression in normal human tissues for BEND6 Gene

mRNA differential expression in normal tissues according to GTEx for BEND6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.9), Brain - Frontal Cortex (BA9) (x5.3), Brain - Cerebellum (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.6).

SOURCE GeneReport for Unigene cluster for BEND6 Gene Hs.582993

genes like me logo Genes that share expression patterns with BEND6: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BEND6 Gene

Orthologs for BEND6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BEND6 35
  • 87.93 (n)
  • 90.68 (a)
BEND6 36
  • 91 (a)
(Canis familiaris)
Mammalia BEND6 35
  • 93.43 (n)
  • 95.7 (a)
BEND6 36
  • 94 (a)
(Mus musculus)
Mammalia Bend6 35
  • 83.39 (n)
  • 83.75 (a)
Bend6 16
Bend6 36
  • 83 (a)
(Pan troglodytes)
Mammalia BEND6 35
  • 99.64 (n)
  • 99.28 (a)
BEND6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Bend6 35
  • 84.09 (n)
  • 84.65 (a)
(Monodelphis domestica)
Mammalia BEND6 36
  • 52 (a)
(Gallus gallus)
Aves BEND6 35
  • 75.77 (n)
  • 75.28 (a)
BEND6 36
  • 73 (a)
Species with no ortholog for BEND6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEND6 Gene

Gene Tree for BEND6 (if available)
Gene Tree for BEND6 (if available)

Paralogs for BEND6 Gene

No data available for Paralogs for BEND6 Gene

Variants for BEND6 Gene

Sequence variations from dbSNP and Humsavar for BEND6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1016048 -- 56,968,031(+) TTATT(C/T)TTATT intron-variant
rs1020550 -- 57,021,538(-) TATAT(C/G/T)AAAAA intron-variant
rs1044670 -- 57,027,181(+) AAGAG(A/G)ATGCT utr-variant-3-prime
rs5876527 -- 57,014,381(+) CTGTG(-/C)CCTCA intron-variant, upstream-variant-2KB
rs5876528 -- 57,015,655(+) AAAAA(-/A)TTAAC intron-variant

Variation tolerance for BEND6 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEND6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEND6 Gene

Disorders for BEND6 Gene

Relevant External Links for BEND6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BEND6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND6 Gene

Publications for BEND6 Gene

  1. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. (PMID: 23571214) Dai Q. … Lai E.C. (Development 2013) 3 4 67
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BEND6 Gene

Sources for BEND6 Gene