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Aliases for BEND6 Gene

Aliases for BEND6 Gene

  • BEN Domain Containing 6 2 3
  • C6orf65 3 4
  • Chromosome 6 Open Reading Frame 65 2
  • BEN Domain-Containing Protein 6 3
  • BA203B9.1 3

External Ids for BEND6 Gene

Previous HGNC Symbols for BEND6 Gene

  • C6orf65

Previous GeneCards Identifiers for BEND6 Gene

  • GC06P056927
  • GC06P056819
  • GC06P056653

Summaries for BEND6 Gene

GeneCards Summary for BEND6 Gene

BEND6 (BEN Domain Containing 6) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathways.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND6 Gene

Genomics for BEND6 Gene

Regulatory Elements for BEND6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BEND6 Gene

56,954,975 bp from pter
57,027,652 bp from pter
72,678 bases
Plus strand

Genomic View for BEND6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BEND6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND6 Gene

Proteins for BEND6 Gene

  • Protein details for BEND6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BEN domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q4G0W8
    • Q8N662
    • Q96NS6

    Protein attributes for BEND6 Gene

    279 amino acids
    Molecular mass:
    31222 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BEND6 Gene


neXtProt entry for BEND6 Gene

Proteomics data for BEND6 Gene at MOPED

Post-translational modifications for BEND6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEND6 Gene

Domains for BEND6 Gene

Gene Families for BEND6 Gene

Protein Domains for BEND6 Gene


Suggested Antigen Peptide Sequences for BEND6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BEN domain.
  • Contains 1 BEN domain.
genes like me logo Genes that share domains with BEND6: view

Function for BEND6 Gene

Gene Ontology (GO) - Molecular Function for BEND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IGI 23571214
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with BEND6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BEND6 Gene

Localization for BEND6 Gene

Subcellular locations from

Jensen Localization Image for BEND6 Gene COMPARTMENTS Subcellular localization image for BEND6 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BEND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BEND6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BEND6 Gene

Pathways for BEND6 Gene

SuperPathways for BEND6 Gene

Superpath Contained pathways
1 Notch Signaling Pathways
genes like me logo Genes that share pathways with BEND6: view

Pathways by source for BEND6 Gene

1 R&D Systems pathway for BEND6 Gene

Interacting Proteins for BEND6 Gene

Gene Ontology (GO) - Biological Process for BEND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
GO:0045746 negative regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with BEND6: view

Transcripts for BEND6 Gene

Unigene Clusters for BEND6 Gene

BEN domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEND6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP2: - - -
SP3: - - -

Relevant External Links for BEND6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEND6 Gene

mRNA expression in normal human tissues for BEND6 Gene

mRNA differential expression in normal tissues according to GTEx for BEND6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.9), Brain - Frontal Cortex (BA9) (5.3), Brain - Cerebellum (5.1), and Brain - Anterior cingulate cortex (BA24) (4.6).

SOURCE GeneReport for Unigene cluster for BEND6 Gene Hs.582993

genes like me logo Genes that share expressions with BEND6: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for BEND6 Gene

Orthologs for BEND6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BEND6 35
  • 87.93 (n)
  • 90.68 (a)
BEND6 36
  • 91 (a)
(Canis familiaris)
Mammalia BEND6 35
  • 93.43 (n)
  • 95.7 (a)
BEND6 36
  • 94 (a)
(Mus musculus)
Mammalia Bend6 35
  • 83.39 (n)
  • 83.75 (a)
Bend6 16
Bend6 36
  • 83 (a)
(Pan troglodytes)
Mammalia BEND6 35
  • 99.64 (n)
  • 99.28 (a)
BEND6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Bend6 35
  • 84.09 (n)
  • 84.65 (a)
(Monodelphis domestica)
Mammalia BEND6 36
  • 52 (a)
(Gallus gallus)
Aves BEND6 35
  • 75.77 (n)
  • 75.28 (a)
BEND6 36
  • 73 (a)
Species with no ortholog for BEND6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEND6 Gene

Gene Tree for BEND6 (if available)
Gene Tree for BEND6 (if available)

Paralogs for BEND6 Gene

No data available for Paralogs for BEND6 Gene

Variants for BEND6 Gene

Sequence variations from dbSNP and Humsavar for BEND6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs720884 -- 57,012,520(+) AACGC(A/G)TCCCC intron-variant, upstream-variant-2KB
rs720885 -- 57,012,662(+) ATTGG(A/G)AAAAA intron-variant, upstream-variant-2KB
rs896442 -- 56,956,672(+) GCATG(C/T)AGGCT intron-variant
rs1007417 -- 56,995,041(-) ataat(A/G)ggaag intron-variant
rs1016048 -- 56,968,031(+) TTATT(C/T)TTATT intron-variant

Relevant External Links for BEND6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEND6 Gene

Disorders for BEND6 Gene

No disorders were found for BEND6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BEND6 Gene

Publications for BEND6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. (PMID: 23571214) Dai Q. … Lai E.C. (Development 2013) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BEND6 Gene

Sources for BEND6 Gene

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