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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BEND6 Gene

protein-coding GIFtS: 37
GCID: GC06P056819

BEN domain containing 6

(Previous name: chromosome 6 open reading frame 65 )
(Previous symbol: C6orf65)

Search for BEND6
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BEN Domain Containing 6¹ ²
C6orf65¹ ² ³
BA203B9.1¹
FLJ30162¹
Chromosome 6 Open Reading Frame 65¹
BEN Domain-Containing Protein 6²

External Ids:	HGNC: 20871¹	Entrez Gene: 221336²	Ensembl: ENSG00000151917⁷	UniProtKB: Q5SZJ8³

Export aliases for BEND6 gene to outside databases

Previous GC identifers: GC06P056927 GC06P056653

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BEND6 gene promoter:
USF1 Lmo2 CUTL1 YY1 c-Ets-1 S8 POU2F1 USF-1 POU2F1a c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BEND6 promoter sequence

Search SABiosciences Chromatin IP Primers for BEND6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEND6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.1

BEND6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEND6 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P056819: view genomic region (about GC identifiers)

Start:	56,819,773 bp from pter	End:	56,892,144 bp from pter
Size:	72,372 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BEND6_HUMAN, Q5SZJ8 (See protein sequence)

Recommended Name: BEN domain-containing protein 6

Size: 279 amino acids; 31222 Da

Secondary accessions: Q4G0W8 Q8N662 Q96NS6

Alternative splicing: 4 isoforms: Q5SZJ8-1 Q5SZJ8-2 Q5SZJ8-3 Q5SZJ8-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BEND6: NX_Q5SZJ8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5SZJ8

BEND6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689944.2

ENSEMBL proteins:

ENSP00000436653 ENSP00000359782 ENSP00000359781 ENSP00000359786 ENSP00000359784

ENSP00000439320

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BEND6 for domains About GeneDecksing

1 InterPro domain/family:

IPR018379 BEN_domain

Graphical View of Domain Structure for InterPro Entry Q5SZJ8

ProtoNet protein and cluster: Q5SZJ8

UniProtKB/Swiss-Prot: BEND6_HUMAN, Q5SZJ8

Similarity: Contains 1 BEN domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BEND6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about BEND6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BEND6 gene:

NM_152731.2

Unigene Cluster for BEND6:

BEN domain containing 6

Hs.582993 [show with all ESTs]

Unigene Representative Sequence: BC036119

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000495359 ENST00000370746 ENST00000370745 ENST00000484701 ENST00000370750(uc010kab.3)

ENST00000370748(uc003pdg.2) ENST00000545789(uc003pdi.4)

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		hsa-miR-548p hsa-miR-361-5p hsa-miR-137 hsa-miR-548e hsa-miR-1301 hsa-miR-545 hsa-miR-29b-1* hsa-miR-519e*

		SwitchGear 3'UTR luciferase reporter plasmid: BEND6 3' UTR sequence

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Additional cDNA sequence:

AK303705.1 AK315926.1 BC022988.1 BC036119.1

7 DOTS entries:

DT.75198382 DT.410408 DT.99936789 DT.100752157 DT.101984225 DT.429617 DT.95139210

24/56 AceView cDNA sequences (see all 56):

BC022988 BX282136 N48613 BG819883 Z40606 CB216049 AW594434 BQ028294

H07984 BP432064 BE855976 BP432054 AK054724 NM_152731 BU684190 AI803591

BC036119 U82774 AI383997 AI933019 BI913530 AA319680 BI914970 BP432062

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BEND6 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10
SP1:
SP2:							-		-				-
SP3:											-		-		-
SP4:

ECgene alternative splicing isoforms for BEND6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BEND6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAAACTTG

About this image

BEND6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BEND6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BEND6

SOURCE GeneReport for Unigene cluster: Hs.582993

SABiosciences Custom PCR Arrays for BEND6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BEND6 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bend6^{1 , 5}	BEN domain containing 6^{1, 5}	83.39(n)¹ 83.75(a)¹		1 (12.85 cM)⁵ 320705¹ NM_177235.3¹ NP_796209.2¹ 33852052⁵
chicken (Gallus gallus)	Aves	BEND6¹	BEN domain containing 6	75.89(n) 75.28(a)		775985 XM_001235555.1 XP_001235556.1

ENSEMBL Gene Tree for BEND6 (if available)
TreeFam Gene Tree for BEND6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148133022^1,2		--	56817911(+)	`GGAAAC/TTATCT`	2	--	int¹ us2k¹		0	--	--	--	--
rs9382669^1,2	C,F,A,H	--	56818146(+)	`CTTTAG/TGAGAA`	2	--	us2k¹ int¹		25		NS EA NA CSA WA	2710
rs185100792^1,2		--	56818270(+)	`AAACAC/TTTCCA`	2	--	int¹ us2k¹		0	--	--	--	--
rs147314678^1,2		--	56818352(+)	`TTTAGA/GGTTTG`	2	--	int¹ us2k¹		0	--	--	--	--
rs141024298^1,2		--	56818385(+)	`GCTCCA/GCTACA`	2	--	int¹ us2k¹		0	--	--	--	--
rs79318542^1,2	F	--	56818409(+)	`AAAACC/GGTTCG`	2	--	us2k¹ int¹		1		WA	118
rs190780716^1,2		--	56818521(+)	`TAATTA/TATATT`	2	--	int¹ us2k¹		0	--	--	--	--
rs115147853^1,2	F	--	56818535(+)	`ACTCAG/AGAAAG`	2	--	int¹ us2k¹		1		WA	118
rs986245^1,2	C,F,A,H	--	56818706(+)	`AGGGTC/TGGGAA`	2	--	us2k¹ int¹		23		MN NS EA NA WA CSA	1978
rs71564870^1,2	C,F	--	56818846(+)	`CCGAAG/CTTTCC`	2	--	us2k¹ int¹		4		NA WA	242

HapMap Linkage Disequilibrium report for BEND6 (56819773 - 56892144 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BEND6: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BEND6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BEND6)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 221336	HGNC: 20871	AceView: C6orf65	Ensembl:ENSG00000151917	euGenes: HUgn221336
ECgene: BEND6	H-InvDB: BEND6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BEND6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BEND6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BEND6 gene:
Search GeneIP for patents involving BEND6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	BEND6 antibodies

	Antibodies for BEND6
	See all of Abcam's Antibodies, Kits and Proteins for BEND6
	Custom Antibody / Protein Production Service
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Browse ProSpec Recombinant Proteins

BEND6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for BEND6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND6

	SwitchGear 3'UTR luciferase reporter plasmids for BEND6
	SwitchGear Promoter luciferase reporter plasmids for BEND6

Search ThermoFisher Antibodies for BEND6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND6

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BEND6

Sirion Biotech Customized:

	stable knockdown cell line services for BEND6
	inducible knockdown cell line services for BEND6
	design and validation of potent shRNA sequences against BEND6
	adenovirus for potent knockdown of BEND6
	adenovirus for overexpression of BEND6
	stable overexpressing cell line services for BEND6
	inducible overexpressing cell line services for BEND6

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes BEND6 gene at Home site.

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BEND6 Gene

BEN domain containing 6

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BEND6 Gene

BEN domain containing 6

Aliasesfor BEND6 gene

Summariesfor BEND6 gene

Genomic Viewsfor BEND6 gene

Proteinsfor BEND6 gene

Protein Domains /Familiesfor BEND6 gene

Functionfor BEND6 gene

Pathways & Interactionsfor BEND6 gene

Drugs & Compoundsfor BEND6 gene

Transcriptsfor BEND6 gene

Expression for BEND6 gene

Orthologsfor BEND6 gene

Paralogsfor BEND6 gene

Genomic Variantsfor BEND6 gene

Disorders / Diseasesfor BEND6 gene

Publicationsfor BEND6 gene

External Searches for BEND6 gene

Genome Databases showing BEND6 gene

Other Databases showing BEND6 gene

Specialized Databases showing BEND6 gene

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Productsfor BEND6 gene

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for BEND6 gene

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for BEND6 gene

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for BEND6 gene

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for BEND6 gene

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Families
for BEND6 gene

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for BEND6 gene

Pathways & Interactions
for BEND6 gene

Drugs & Compounds
for BEND6 gene

Transcripts
for BEND6 gene

Expression
for BEND6 gene

Orthologs
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for BEND6 gene

Disorders / Diseases
for BEND6 gene

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for BEND6 gene

Intellectual Property
for BEND6 gene

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for BEND6 gene