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Aliases for BEND6 Gene

Aliases for BEND6 Gene

  • BEN Domain Containing 6 2 3 5
  • C6orf65 3 4
  • Chromosome 6 Open Reading Frame 65 2
  • BEN Domain-Containing Protein 6 3

External Ids for BEND6 Gene

Previous HGNC Symbols for BEND6 Gene

  • C6orf65

Previous GeneCards Identifiers for BEND6 Gene

  • GC06P056927
  • GC06P056819
  • GC06P056653

Summaries for BEND6 Gene

GeneCards Summary for BEND6 Gene

BEND6 (BEN Domain Containing 6) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG). GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity.

UniProtKB/Swiss-Prot for BEND6 Gene

  • Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND6 Gene

Genomics for BEND6 Gene

Regulatory Elements for BEND6 Gene

Enhancers for BEND6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F056904 1.1 Ensembl ENCODE 51 -50.2 -50208 1.1 HDGF BCOR CTCF PKNOX1 ZNF792 ARID4B ZNF384 CEBPG BCL11B ZNF2 BEND6 DST BAG2 LOC101927211 GC06M056915 GC06P056873
GH06F056952 1.1 ENCODE 50.6 -0.4 -376 3.2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS SP3 SP5 BEND6 KIAA1586 LOC101927211 DST GC06M056952
GH06F056901 1.1 Ensembl ENCODE 45.9 -52.4 -52387 1.7 PKNOX1 ZFP64 RAD21 CBX5 ZNF143 ETV6 CREM ZNF202 ZNF680 ZNF654 BEND6 LOC101927211 KIAA1586 DST BAG2 GC06M056915 GC06P056873
GH06F056957 0.9 Ensembl ENCODE 48.6 +4.2 4221 2.4 JUN SIN3A JUND STAT3 FOS KDM1A MAFK NFE2L2 BEND6 KIAA1586 OSTCP6
GH06F056937 1.1 Ensembl ENCODE 31.5 -16.3 -16349 2.0 TBP SIN3A FEZF1 BRCA1 RFX5 GTF3C2 SCRT2 ZNF143 RCOR1 FOS BEND6 GC06M056941 PIR47456 GC06M056915
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BEND6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEND6 Gene

Chromosome:
6
Start:
56,954,975 bp from pter
End:
57,027,652 bp from pter
Size:
72,678 bases
Orientation:
Plus strand

Genomic View for BEND6 Gene

Genes around BEND6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND6 Gene

Proteins for BEND6 Gene

  • Protein details for BEND6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZJ8-BEND6_HUMAN
    Recommended name:
    BEN domain-containing protein 6
    Protein Accession:
    Q5SZJ8
    Secondary Accessions:
    • Q4G0W8
    • Q8N662
    • Q96NS6

    Protein attributes for BEND6 Gene

    Size:
    279 amino acids
    Molecular mass:
    31222 Da
    Quaternary structure:
    • Interacts (via BEN domain) with RBPJ.

    Alternative splice isoforms for BEND6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BEND6 Gene

Post-translational modifications for BEND6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BEND6 Gene

Domains & Families for BEND6 Gene

Gene Families for BEND6 Gene

Protein Domains for BEND6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEND6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SZJ8

UniProtKB/Swiss-Prot:

BEND6_HUMAN :
  • Contains 1 BEN domain.
Domain:
  • Contains 1 BEN domain.
genes like me logo Genes that share domains with BEND6: view

Function for BEND6 Gene

Molecular function for BEND6 Gene

UniProtKB/Swiss-Prot Function:
Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).

Gene Ontology (GO) - Molecular Function for BEND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IGI 23571214
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with BEND6: view
genes like me logo Genes that share phenotypes with BEND6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEND6 Gene

Localization for BEND6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEND6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEND6 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BEND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BEND6: view

Pathways & Interactions for BEND6 Gene

SuperPathways for BEND6 Gene

SuperPathway Contained pathways
1 Notch signaling pathway (KEGG)
genes like me logo Genes that share pathways with BEND6: view

Pathways by source for BEND6 Gene

1 R&D Systems pathway for BEND6 Gene

Interacting Proteins for BEND6 Gene

Gene Ontology (GO) - Biological Process for BEND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with BEND6: view

No data available for SIGNOR curated interactions for BEND6 Gene

Transcripts for BEND6 Gene

Unigene Clusters for BEND6 Gene

BEN domain containing 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEND6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2: - - -
SP3: - - -
SP4:

Relevant External Links for BEND6 Gene

GeneLoc Exon Structure for
BEND6
ECgene alternative splicing isoforms for
BEND6

Expression for BEND6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BEND6 Gene

mRNA differential expression in normal tissues according to GTEx for BEND6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.9), Brain - Frontal Cortex (BA9) (x5.3), Brain - Cerebellum (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of BEND6 Gene:

BEND6

SOURCE GeneReport for Unigene cluster for BEND6 Gene:

Hs.582993
genes like me logo Genes that share expression patterns with BEND6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BEND6 Gene

Orthologs for BEND6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEND6 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia BEND6 34 35
  • 93.43 (n)
cow
(Bos Taurus)
Mammalia BEND6 34 35
  • 87.93 (n)
rat
(Rattus norvegicus)
Mammalia Bend6 34
  • 84.09 (n)
mouse
(Mus musculus)
Mammalia Bend6 34 16 35
  • 83.39 (n)
oppossum
(Monodelphis domestica)
Mammalia BEND6 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves BEND6 34 35
  • 75.77 (n)
Species where no ortholog for BEND6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEND6 Gene

ENSEMBL:
Gene Tree for BEND6 (if available)
TreeFam:
Gene Tree for BEND6 (if available)

Paralogs for BEND6 Gene

No data available for Paralogs for BEND6 Gene

Variants for BEND6 Gene

Sequence variations from dbSNP and Humsavar for BEND6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1007417 -- 56,995,041(-) ataat(A/G)ggaag intron-variant
rs1016048 -- 56,968,031(+) TTATT(C/T)TTATT intron-variant
rs1020550 -- 57,021,538(-) TATAT(C/T)AAAAA intron-variant
rs1044670 -- 57,027,181(+) AAGAG(A/G)ATGCT nc-transcript-variant, utr-variant-3-prime
rs111317872 -- 57,022,574(+) ACCAG(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BEND6 Gene

Variant ID Type Subtype PubMed ID
nsv970124 CNV duplication 23825009
nsv1073562 CNV deletion 25765185
dgv3319n106 CNV deletion 24896259

Variation tolerance for BEND6 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEND6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BEND6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEND6 Gene

Disorders for BEND6 Gene

Relevant External Links for BEND6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEND6

No disorders were found for BEND6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND6 Gene

Publications for BEND6 Gene

  1. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. (PMID: 23571214) Dai Q. … Lai E.C. (Development 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for BEND6 Gene

Sources for BEND6 Gene

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