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Aliases for BEND5 Gene

Aliases for BEND5 Gene

  • BEN Domain Containing 5 2 3 5
  • C1orf165 3 4
  • Chromosome 1 Open Reading Frame 165 2

External Ids for BEND5 Gene

Previous HGNC Symbols for BEND5 Gene

  • C1orf165

Previous GeneCards Identifiers for BEND5 Gene

  • GC01M048966
  • GC01M049193
  • GC01M047312

Summaries for BEND5 Gene

GeneCards Summary for BEND5 Gene

BEND5 (BEN Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BEND5 Gene

  • Acts as a transcriptional repressor (PubMed:23468431).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND5 Gene

Genomics for BEND5 Gene

Regulatory Elements for BEND5 Gene

Enhancers for BEND5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BEND5 on UCSC Golden Path with GeneCards custom track

Promoters for BEND5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BEND5 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEND5 Gene

48,727,523 bp from pter
48,776,969 bp from pter
49,447 bases
Minus strand

Genomic View for BEND5 Gene

Genes around BEND5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND5 Gene

Proteins for BEND5 Gene

  • Protein details for BEND5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BEN domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • D3DQ27
    • Q96A62
    • Q9HAI3

    Protein attributes for BEND5 Gene

    421 amino acids
    Molecular mass:
    48182 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11804.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BEND5 Gene


neXtProt entry for BEND5 Gene

Proteomics data for BEND5 Gene at MOPED

Post-translational modifications for BEND5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEND5 Gene

Domains & Families for BEND5 Gene

Gene Families for BEND5 Gene

Protein Domains for BEND5 Gene


Suggested Antigen Peptide Sequences for BEND5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The BEN domain mediates DNA-binding.
  • The BEN domain mediates DNA-binding.
  • Contains 1 BEN domain.
genes like me logo Genes that share domains with BEND5: view

Function for BEND5 Gene

Molecular function for BEND5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor (PubMed:23468431).
genes like me logo Genes that share phenotypes with BEND5: view

Animal Model Products

CRISPR Products

miRNA for BEND5 Gene

miRTarBase miRNAs that target BEND5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEND5 Gene

Localization for BEND5 Gene

Subcellular locations from

Jensen Localization Image for BEND5 Gene COMPARTMENTS Subcellular localization image for BEND5 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BEND5 Gene

Pathways & Interactions for BEND5 Gene

SuperPathways for BEND5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 23468431
genes like me logo Genes that share ontologies with BEND5: view

No data available for Pathways by source and SIGNOR curated interactions for BEND5 Gene

Drugs & Compounds for BEND5 Gene

No Compound Related Data Available

Transcripts for BEND5 Gene

Unigene Clusters for BEND5 Gene

BEN domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEND5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: -
SP2: - -
SP4: - -

Relevant External Links for BEND5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEND5 Gene

mRNA expression in normal human tissues for BEND5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BEND5 Gene

This gene is overexpressed in Plasma (24.7), Spleen (14.4), Testis (11.6), and Uterus (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BEND5 Gene

SOURCE GeneReport for Unigene cluster for BEND5 Gene Hs.475348

genes like me logo Genes that share expression patterns with BEND5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BEND5 Gene

Orthologs for BEND5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BEND5 35
  • 95.72 (n)
  • 98.1 (a)
BEND5 36
  • 98 (a)
(Canis familiaris)
Mammalia BEND5 35
  • 93.92 (n)
  • 97.72 (a)
BEND5 36
  • 96 (a)
(Mus musculus)
Mammalia Bend5 35
  • 94.46 (n)
  • 98.57 (a)
Bend5 16
Bend5 36
  • 99 (a)
(Pan troglodytes)
Mammalia BEND5 35
  • 99.84 (n)
  • 100 (a)
BEND5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bend5 35
  • 93.9 (n)
  • 97.62 (a)
(Ornithorhynchus anatinus)
Mammalia BEND5 36
  • 73 (a)
(Gallus gallus)
Aves BEND5 35
  • 81.29 (n)
  • 87.23 (a)
BEND5 36
  • 86 (a)
(Anolis carolinensis)
Reptilia BEND5 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bend5 35
  • 71.56 (n)
  • 76.28 (a)
(Danio rerio)
Actinopterygii bend5 35
  • 64.52 (n)
  • 66.07 (a)
bend5 36
  • 61 (a)
Species with no ortholog for BEND5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEND5 Gene

Gene Tree for BEND5 (if available)
Gene Tree for BEND5 (if available)

Paralogs for BEND5 Gene

No data available for Paralogs for BEND5 Gene

Variants for BEND5 Gene

Structural Variations from Database of Genomic Variants (DGV) for BEND5 Gene

Variant ID Type Subtype PubMed ID
nsv871053 CNV Gain 21882294
nsv829771 CNV Gain 17160897

Variation tolerance for BEND5 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for BEND5 Gene

Disorders for BEND5 Gene

Relevant External Links for BEND5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BEND5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND5 Gene

Publications for BEND5 Gene

  1. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. (PMID: 23468431) Dai Q. … Lai E.C. (Genes Dev. 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for BEND5 Gene

Sources for BEND5 Gene