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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BEND5 Gene

protein-coding GIFtS: 44
GCID: GC01M049193

BEN domain containing 5

(Previous name: chromosome 1 open reading frame 165 )
(Previous symbol: C1orf165)

Explore 1 disease affiliated with
BEND5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BEN Domain Containing 5¹ ²
C1orf165¹ ² ³
FLJ11588¹
Chromosome 1 Open Reading Frame 165¹
BEN Domain-Containing Protein 5²

External Ids:	HGNC: 25668¹	Entrez Gene: 79656²	Ensembl: ENSG00000162373⁷	UniProtKB: Q7L4P6³

Export aliases for BEND5 gene to outside databases

Previous GC identifers: GC01M048966 GC01M047312

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BEND5 gene promoter:
C/EBPbeta Brachyury CUTL1 Nkx2-5 POU3F2 Max Ik-2 POU2F1 POU2F1a c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for BEND5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEND5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33

BEND5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEND5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M049193: view genomic region (about GC identifiers)

Start:	49,193,195 bp from pter	End:	49,242,641 bp from pter
Size:	49,447 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BEND5_HUMAN, Q7L4P6 (See protein sequence)

Recommended Name: BEN domain-containing protein 5

Size: 421 amino acids; 48182 Da

Sequence caution: Sequence=AAH11804.1; Type=Erroneous initiation;

Secondary accessions: D3DQ27 Q96A62 Q9HAI3

Alternative splicing: 2 isoforms: Q7L4P6-1 Q7L4P6-2

Explore the universe of human proteins at neXtProt for BEND5: NX_Q7L4P6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7L4P6

BEND5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_078879.2

ENSEMBL proteins:

ENSP00000360899

Human Recombinant Protein Products:

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	Uscn Proteins for BEND5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--

BEND5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BEND5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BEND5 for domains About GeneDecksing

1 InterPro domain/family:

IPR018379 BEN_domain

Graphical View of Domain Structure for InterPro Entry Q7L4P6

ProtoNet protein and cluster: Q7L4P6

UniProtKB/Swiss-Prot: BEND5_HUMAN, Q7L4P6

Similarity: Contains 1 BEN domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BEND5
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND5

1 GenomeRNAi human phenotype for BEND5:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BEND5

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for BEND5 (Q7L4P6^{2, 3} ENSP00000360899⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GFI1B	Q5VTD9²^,³, ENSP00000344782⁴	MINT-2876349 I2D: score=3 STRING: ENSP00000344782
USP7	Q93009²^,³, ENSP00000343535⁴	MINT-2876368 I2D: score=3 STRING: ENSP00000343535
USP2	O75604³, ENSP00000260187⁴	I2D: score=4 STRING: ENSP00000260187
MAP1LC3A	Q9H492³, ENSP00000363970⁴	I2D: score=1 STRING: ENSP00000363970
CTNNBIP1	Q9NSA3³, ENSP00000366466⁴	I2D: score=4 STRING: ENSP00000366466

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BEND5
Search CenterWatch for drugs/clinical trials and news about BEND5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BEND5 gene:

NM_024603.2

Unigene Cluster for BEND5:

BEN domain containing 5

Hs.475348 [show with all ESTs]

Unigene Representative Sequence: AK096573

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371833(uc001crx.4) ENST00000476079 ENST00000463562(uc001crw.4)

ENST00000476096 ENST00000480399 ENST00000489956

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BEND5

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEND5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEND5

Additional cDNA sequence:

AK021650.1 AK055449.1 AK096573.1 BC007932.2 BC011804.2

10 DOTS entries:

DT.112826 DT.100775920 DT.440273 DT.91857441 DT.100704397 DT.100775919 DT.121443663 DT.121443686

DT.121443683 DT.121443702

24/98 AceView cDNA sequences (see all 98):

AI690013 AI378659 BE674366 BC007932 BM930480 BC011804 AA828273 CK300320

AI648368 BM683273 BU743157 AU118499 BG217746 AI870010 AW292205 BQ006447

BQ352718 CD671200 C02495 NM_024603 AI305211 AI659592 BX096297 BE719204

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BEND5 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5
SP1:					-
SP2:					-		-
SP3:
SP4:			-		-

ECgene alternative splicing isoforms for BEND5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BEND5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATATCAATA

About this image

BEND5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BEND5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BEND5

SOURCE GeneReport for Unigene cluster: Hs.475348

SABiosciences Custom PCR Arrays for BEND5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEND5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BEND5 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bend5^{1 , 5}	BEN domain containing 5^{1, 5}	94.46(n)¹ 98.57(a)¹		4 (51.53 cM)⁵ 67621¹ NM_026279.3¹ NP_080555.1¹ 111415006⁵
chicken (Gallus gallus)	Aves	BEND5¹	BEN domain containing 5	81.2(n) 87.23(a)		424628 XM_001234080.1 XP_001234081.1
lizard (Anolis carolinensis)	Reptilia	BEND5⁶	--	81(a)	1 ↔ 1	GL343485.1(193275-236104)
zebrafish (Danio rerio)	Actinopterygii	bend5⁶	BEN domain containing 5	60(a)	1 ↔ 1	8(16020966-16037550)

ENSEMBL Gene Tree for BEND5 (if available)
TreeFam Gene Tree for BEND5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146852545^1,2	C,	--	49193040(+)	`TTCAGA/GTCTGT`	2	--	int¹		0	--	--	--	--
rs186580328^1,2		--	49193103(+)	`TTCCCG/TGAAAG`	2	--	int¹		0	--	--	--	--
rs113095649^1,2	C,F,	--	49193124(+)	`CCAGGC/TGGCAC`	2	--	int¹		4		WA CSA	124
rs191075336^1,2		--	49193125(+)	`CAGGCA/GGCACA`	2	--	int¹		0	--	--	--	--
rs2291335^1,2	C,F,H,	--	49193129(+)	`CGGCAC/TAACAC`	2	--	int¹		20		NS EA NA WA	2338
rs183743183^1,2		--	49193359(+)	`AGTGCC/TAGGCT`	2	--	int¹		0	--	--	--	--
rs1385152^1,2	C,F,O,H,	--	49193394(+)	`CTGTCG/TTCTTT`	2	--	int¹ ese³		116		NS MN EA NA PA EU CA WA CSA	8112
rs201845816^1,2	C,F,	--	49193533(+)	`AACACG/AAAAGC`	2	--	int¹		1		EU	1323
rs186920009^1,2	C,	--	49193544(+)	`TTTATC/GAAAAA`	2	--	int¹ ut3¹		0	--	--	--	--
rs139205698^1,2	C,F	--	49193582(+)	`GCTTCC/TCTTCG`	3	R	int¹ syn¹		2		NA EU	5865

HapMap Linkage Disequilibrium report for BEND5 (49193195 - 49242641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BEND5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEND5

DNA2.0 Custom Variant and Variant Library Synthesis for BEND5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BEND5 for disorders About GeneDecksing

1 disease for BEND5: About MalaCards

ataxia

Export disorders for BEND5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BEND5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BEND5)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79656	HGNC: 25668	AceView: FLJ11588	Ensembl:ENSG00000162373	euGenes: HUgn79656
ECgene: BEND5	H-InvDB: BEND5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BEND5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BEND5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BEND5 gene:
Search GeneIP for patents involving BEND5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	GenScript Custom Purified and Recombinant Proteins Services for BEND5		GenScript cDNA clones with any tag delivered in your preferred vector for BEND5
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes BEND5 gene at Home site.

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BEND5 Gene

BEN domain containing 5

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BEND5 Gene

BEN domain containing 5

Aliasesfor BEND5 gene

Summariesfor BEND5 gene

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Proteinsfor BEND5 gene

Protein Domains /Familiesfor BEND5 gene

Functionfor BEND5 gene

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