BEND4 Gene
protein-coding GIFtS: 37
GCID: GC04M042112
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BEN domain containing 4(Previous name: coiled-coil domain containing 4 )
(Previous symbol: CCDC4)
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Aliases
for BEND4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BEN Domain Containing 41 2 | | FLJ356321 | | CCDC41 2 3 | | FLJ439651 | | Coiled-Coil Domain Containing 41 2 | | BEN Domain-Containing Protein 42 | | Coiled-Coil Domain-Containing Protein 42 3 | | |
Export aliases for BEND4 gene to outside databasesPrevious GC identifers: GC04M041808 GC04M041434 |
Summaries
for BEND4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for BEND4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006238.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BEND4 gene promoter:
SRF GR GR-beta Pax-2 Pax-2a Nkx2-5 Evi-1 POU2F1 POU2F1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for BEND4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEND4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p13 HGNC cytogenetic band: 4p13BEND4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M042112: view genomic region
(about GC identifiers)
Start:
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42,112,870 bp from pter |
End:
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42,154,895 bp from pter |
Size:
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42,026 bases |
Orientation:
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minus strand |
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Proteins
for BEND4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: BEND4_HUMAN, Q6ZU67 (See
protein sequence)Recommended Name: BEN domain-containing protein 4 Size: 534 amino acids; 58375 Da
Sequence caution: Sequence=AAI28593.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAI28594.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD93191.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD93192.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
Secondary accessions: A1A5D6 A1A5D7 C9JQZ5 Q58A26 Q58A27Alternative splicing: 5 isoforms: Q6ZU67-1 Q6ZU67-2 Q6ZU67-3 Q6ZU67-4 Q6ZU67-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BEND4: NX_Q6ZU67
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZU67
BEND4 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001153019.1 NP_997289.2
ENSEMBL proteins: ENSP00000421169 ENSP00000421160
Human Recombinant Protein Products:
BEND4 Antibody Products:
Assay Products for BEND4: |
Protein
Domains /
Families
for BEND4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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BEND4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZU67ProtoNet protein and cluster: Q6ZU67 UniProtKB/Swiss-Prot: BEND4_HUMAN, Q6ZU67Similarity: Contains 1 BEN domain |
Function
for BEND4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEND4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEND4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BEND4 (NM_001159547) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BEND4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND4 |
1 GenomeRNAi human phenotype for BEND4:
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Pathways & Interactions
for BEND4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BEND4
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Drugs & Compounds
for BEND4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BEND4
Search CenterWatch for drugs/clinical trials and news about BEND4
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Transcripts
for BEND4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for BEND4 gene (2 alternative transcripts): NM_001159547.1 NM_207406.3 Unigene Cluster for BEND4: BEN domain containing 4 Hs.120591 [show with all ESTs]Unigene Representative Sequence: NM_2074062 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000502486(uc003gwn.3 uc003gwm.3 uc011byy.1) ENST00000504360
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEND4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEND4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BEND4 (NM_001159547) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BEND4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND4 |
Additional cDNA sequence: AB126828.1 AB126829.1 AK092951.1 AK125953.1 BC128592.1 BC128593.1 5 DOTS entries: DT.100009753 DT.107175 DT.107176 DT.121222397 DT.121222399 7 AceView cDNA sequences: T25372 AA714025 NM_207406 AK125953 BG113872 AA810297 CF134945
GeneLoc Exon Structure
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Expression
for BEND4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BEND4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGAAAAT
About this image
Genevestigator expression for BEND4
SOURCE GeneReport for Unigene cluster: Hs.120591
SABiosciences Custom PCR Arrays for BEND4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEND4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BEND4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEND4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEND4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND4 |
Orthologs
for BEND4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for BEND4 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for BEND4 (if available)
TreeFam Gene Tree for BEND4 (if available) |
Paralogs
for BEND4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for BEND4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEND4 |
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Disorders
/ Diseases
for BEND4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for BEND4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for BEND4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BEND4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for BEND4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing BEND4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing BEND4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BEND4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BEND4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for BEND4 gene:
Search GeneIP for patents involving BEND4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BEND4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BEND4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BEND4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEND4 | | | OriGene Protein Over-expression Lysate for BEND4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BEND4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEND4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEND4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BEND4 | | OriGene Custom Protein Services for BEND4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BEND4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEND4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEND4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BEND4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEND4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEND4 |
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| | | | Search Tocris compounds for BEND4 |
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 | | | BEND4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND4 |
|  |  |  | | | | Search ThermoFisher Antibodies for BEND4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND4 |
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