BEND3 Gene
protein-coding GIFtS: 41
GCID: GC06M107386
|
|
BEN domain containing 3(Previous name: KIAA1553 )
(Previous symbol: KIAA1553)
| |
Aliases
for BEND3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BEN Domain Containing 31 2 | | KIAA15531 2 3 | | RP11-59I9.22 | | BEN Domain-Containing Protein 32 |
Export aliases for BEND3 gene to outside databasesPrevious GC identifers: GC06M107494 GC06M104957 |
Summaries
for BEND3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BEND3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BEND3 gene promoter:
RFX1 p53 POU6F1 (c2) MEF-2A CBF-A CP1A aMEF-2 NF-Y RSRFC4 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for BEND3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEND3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21BEND3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M107386: view genomic region
(about GC identifiers)
Start:
|
107,386,385 bp from pter |
End:
|
107,436,473 bp from pter |
Size:
|
50,089 bases |
Orientation:
|
minus strand |
|
Proteins
for BEND3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BEND3_HUMAN, Q5T5X7 (See
protein sequence)Recommended Name: BEN domain-containing protein 3 Size: 828 amino acids; 94475 Da
Secondary accessions: A2RRH2 Q9HCL9Explore the universe of human proteins at neXtProt for BEND3: NX_Q5T5X7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T5X7
BEND3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073919.1
ENSEMBL proteins: ENSP00000358038 ENSP00000411268
Human Recombinant Protein Products:
BEND3 Antibody Products:
Assay Products for BEND3: |
Protein
Domains /
Families
for BEND3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BEND3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T5X7ProtoNet protein and cluster: Q5T5X7 UniProtKB/Swiss-Prot: BEND3_HUMAN, Q5T5X7Similarity: Contains 4 BEN domains |
Function
for BEND3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEND3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEND3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BEND3 (NM_001080450) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BEND3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND3 |
2 GenomeRNAi human phenotypes for BEND3:
|
Pathways & Interactions
for BEND3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BEND3
5/33 Interacting proteins for BEND3 (Q5T5X72, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 33)About this table
|
Drugs & Compounds
for BEND3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BEND3
Search CenterWatch for drugs/clinical trials and news about BEND3
|
Transcripts
for BEND3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BEND3 gene: NM_001080450.2 Unigene Cluster for BEND3: BEN domain containing 3 Hs.418045 [show with all ESTs]Unigene Representative Sequence: NM_0010804502 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369042 ENST00000429433(uc003prs.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEND3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEND3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BEND3 (NM_001080450) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BEND3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND3 |
Additional cDNA sequence: AB046773.1 AK026996.1 BC131628.1 2 DOTS entries: DT.312546 DT.121355460 24/55 AceView cDNA sequences (see all 55): BU624353 BU179685 AI793293 AI733269 AB046773 T32552 AA604028 F10007 Z38770 BQ686361 AI792975 Z42590 AI671193 BQ018442 BM968747 AA931780 T74430 BX506710 AA935776 AK026996 BQ686987 BU167471 BU150080 BQ877225
GeneLoc Exon Structure
|
Expression
for BEND3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BEND3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGCATTTT
About this image
See BEND3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BEND3
SOURCE GeneReport for Unigene cluster: Hs.418045
SABiosciences Custom PCR Arrays for BEND3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEND3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BEND3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEND3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEND3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND3 |
Orthologs
for BEND3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BEND3 gene from 4/8 species (see all 8) About this table
ENSEMBL Gene Tree for BEND3 (if available)
TreeFam Gene Tree for BEND3 (if available) |
Paralogs
for BEND3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BEND3 gene
BEND3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for BEND3
PGOHUM00000238795 PGOHUM00000238853 PGOHUM00000236706
|
Genomic Variants
for BEND3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BEND3 (107386385 - 107436473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for BEND3
2 CNVs: 69583 4504
1 Indel: 28056 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEND3 |
|
Disorders
/ Diseases
for BEND3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 BEND3 for disorders About MalaCards
BEND3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: BEND3 (1 document)
Export disorders for BEND3 gene to outside databases
|
Publications
for BEND3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BEND3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with BEND3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Human CCAAT/enhancer-binding protein b interacts with chromatin remodeling complexes of the imitation switch subfamily. (PubMed id 22242598)1 Steinberg X.P....Gutierrez J.L. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
- A BEN-domain-containing protein associates with heter ochromatin and represses transcription. (PubMed id 21914818)1 Sathyan K.M....Prasanth S.G. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for BEND3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BEND3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BEND3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing BEND3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BEND3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BEND3 gene:
Search GeneIP for patents involving BEND3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BEND3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BEND3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BEND3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BEND3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BEND3 | | OriGene 3'-UTR Clone for BEND3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BEND3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEND3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BEND3 | | OriGene Custom Protein Services for BEND3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BEND3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BEND3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEND3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BEND3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEND3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEND3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BEND3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | BEND3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEND3 |
|  |  |  | | | | Search ThermoFisher Antibodies for BEND3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEND3 |
|
|
|
|
