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Aliases for BEND2 Gene

Aliases for BEND2 Gene

  • BEN Domain Containing 2 2 3 5
  • CXorf20 3 4
  • Chromosome X Open Reading Frame 20 2

External Ids for BEND2 Gene

Previous HGNC Symbols for BEND2 Gene

  • CXorf20

Previous GeneCards Identifiers for BEND2 Gene

  • GC0XM015938

Summaries for BEND2 Gene

Entrez Gene Summary for BEND2 Gene

  • This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for BEND2 Gene

BEND2 (BEN Domain Containing 2) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND2 Gene

Genomics for BEND2 Gene

Regulatory Elements for BEND2 Gene

Genomic Location for BEND2 Gene

Chromosome:
X
Start:
18,162,931 bp from pter
End:
18,220,904 bp from pter
Size:
57,974 bases
Orientation:
Minus strand

Genomic View for BEND2 Gene

Genes around BEND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND2 Gene

Proteins for BEND2 Gene

  • Protein details for BEND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDZ0-BEND2_HUMAN
    Recommended name:
    BEN domain-containing protein 2
    Protein Accession:
    Q8NDZ0
    Secondary Accessions:
    • E9PFY2
    • Q4V9S2
    • Q5JXE5

    Protein attributes for BEND2 Gene

    Size:
    799 amino acids
    Molecular mass:
    87919 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BEND2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BEND2 Gene

Proteomics data for BEND2 Gene at MOPED

Post-translational modifications for BEND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEND2 Gene

Domains & Families for BEND2 Gene

Gene Families for BEND2 Gene

Protein Domains for BEND2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEND2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NDZ0

UniProtKB/Swiss-Prot:

BEND2_HUMAN :
  • Contains 2 BEN domains.
Domain:
  • Contains 2 BEN domains.
genes like me logo Genes that share domains with BEND2: view

Function for BEND2 Gene

genes like me logo Genes that share phenotypes with BEND2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BEND2 Gene

Localization for BEND2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEND2 Gene COMPARTMENTS Subcellular localization image for BEND2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BEND2 Gene

Pathways & Interactions for BEND2 Gene

SuperPathways for BEND2 Gene

No Data Available

Interacting Proteins for BEND2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369372%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: Q8NDZ0-BEND2_HUMAN ENSP00000369372 for BEND2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for BEND2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BEND2 Gene

Drugs & Compounds for BEND2 Gene

No Compound Related Data Available

Transcripts for BEND2 Gene

mRNA/cDNA for BEND2 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEND2 Gene

BEN domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEND2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1:
SP2:
SP3:

Relevant External Links for BEND2 Gene

GeneLoc Exon Structure for
BEND2
ECgene alternative splicing isoforms for
BEND2

Expression for BEND2 Gene

mRNA expression in normal human tissues for BEND2 Gene

mRNA differential expression in normal tissues according to GTEx for BEND2 Gene

This gene is overexpressed in Testis (x35.8) and Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for BEND2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BEND2 Gene



SOURCE GeneReport for Unigene cluster for BEND2 Gene Hs.403802

genes like me logo Genes that share expression patterns with BEND2: view

Protein tissue co-expression partners for BEND2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BEND2 Gene

Orthologs for BEND2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEND2 35
  • 95.05 (n)
  • 92.12 (a)
BEND2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BEND2 36
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BEND2 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BEND2 36
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves BEND2 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BEND2 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BEND2 (1 of 2) 36
  • 22 (a)
OneToMany
BEND2 (2 of 2) 36
  • 16 (a)
OneToMany
Species with no ortholog for BEND2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEND2 Gene

ENSEMBL:
Gene Tree for BEND2 (if available)
TreeFam:
Gene Tree for BEND2 (if available)

Paralogs for BEND2 Gene

(6) SIMAP similar genes for BEND2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEND2: view

No data available for Paralogs for BEND2 Gene

Variants for BEND2 Gene

Sequence variations from dbSNP and Humsavar for BEND2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs17274127 - 18,212,595(+) TTTGG(A/C)AAATC reference, missense
rs12859329 - 18,203,845(+) CAAGA(A/G)ATGTT reference, missense
rs3082649 -- 18,177,277(+) TTTTT(-/TT)GTAGC intron-variant
rs4825353 -- 18,192,806(+) gatga(A/C)tgttc intron-variant
rs4825354 -- 18,215,509(+) CATAA(A/G)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BEND2 Gene

Variant ID Type Subtype PubMed ID
nsv510818 CNV Loss 20534489

Variation tolerance for BEND2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEND2 Gene

HapMap Linkage Disequilibrium report
BEND2
Human Gene Mutation Database (HGMD)
BEND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEND2 Gene

Disorders for BEND2 Gene

Relevant External Links for BEND2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEND2

No disorders were found for BEND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND2 Gene

Publications for BEND2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Epileptic encephalopathy in a girl with an interstitial deletion of Xp22 comprising promoter and exon 1 of the CDKL5 gene. (PMID: 19455595) Bahi-Buisson N. … Bienvenu T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for BEND2 Gene

Sources for BEND2 Gene

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