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Aliases for BEND2 Gene

Aliases for BEND2 Gene

  • BEN Domain Containing 2 2 3 5
  • CXorf20 3 4
  • Chromosome X Open Reading Frame 20 2
  • BEN Domain-Containing Protein 2 3

External Ids for BEND2 Gene

Previous HGNC Symbols for BEND2 Gene

  • CXorf20

Previous GeneCards Identifiers for BEND2 Gene

  • GC0XM015938

Summaries for BEND2 Gene

Entrez Gene Summary for BEND2 Gene

  • This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for BEND2 Gene

BEND2 (BEN Domain Containing 2) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND2 Gene

Genomics for BEND2 Gene

Regulatory Elements for BEND2 Gene

Enhancers for BEND2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF018219 0.2 Ensembl 0.8 +1.6 1604 0.6 BEND2 GC0XM017968
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BEND2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BEND2 Gene

18,162,931 bp from pter
18,220,904 bp from pter
57,974 bases
Minus strand

Genomic View for BEND2 Gene

Genes around BEND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND2 Gene

Proteins for BEND2 Gene

  • Protein details for BEND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BEN domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • E9PFY2
    • Q4V9S2
    • Q5JXE5

    Protein attributes for BEND2 Gene

    799 amino acids
    Molecular mass:
    87919 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BEND2 Gene


neXtProt entry for BEND2 Gene

Post-translational modifications for BEND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND2 Gene

No data available for DME Specific Peptides for BEND2 Gene

Domains & Families for BEND2 Gene

Gene Families for BEND2 Gene

Protein Domains for BEND2 Gene


Suggested Antigen Peptide Sequences for BEND2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 BEN domains.
  • Contains 2 BEN domains.
genes like me logo Genes that share domains with BEND2: view

Function for BEND2 Gene

genes like me logo Genes that share phenotypes with BEND2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BEND2 Gene

Localization for BEND2 Gene

Subcellular locations from

Jensen Localization Image for BEND2 Gene COMPARTMENTS Subcellular localization image for BEND2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BEND2 Gene

Pathways & Interactions for BEND2 Gene

SuperPathways for BEND2 Gene

No Data Available

Interacting Proteins for BEND2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8NDZ0-BEND2_HUMAN ENSP00000369372 for BEND2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for BEND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048741 NOT skeletal muscle fiber development IBA --
genes like me logo Genes that share ontologies with BEND2: view

No data available for Pathways by source and SIGNOR curated interactions for BEND2 Gene

Transcripts for BEND2 Gene

mRNA/cDNA for BEND2 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEND2 Gene

BEN domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEND2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5

Relevant External Links for BEND2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEND2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BEND2 Gene

mRNA differential expression in normal tissues according to GTEx for BEND2 Gene

This gene is overexpressed in Testis (x35.8) and Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for BEND2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BEND2 Gene

Protein tissue co-expression partners for BEND2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BEND2 Gene:


SOURCE GeneReport for Unigene cluster for BEND2 Gene:

genes like me logo Genes that share expression patterns with BEND2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BEND2 Gene

Orthologs for BEND2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BEND2 34 35
  • 95.05 (n)
(Bos Taurus)
Mammalia BEND2 35
  • 44 (a)
(Canis familiaris)
Mammalia BEND2 35
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia BEND2 35
  • 30 (a)
(Gallus gallus)
Aves BEND2 35
  • 32 (a)
(Anolis carolinensis)
Reptilia BEND2 35
  • 42 (a)
(Danio rerio)
Actinopterygii BEND2 (1 of 2) 35
  • 22 (a)
BEND2 (2 of 2) 35
  • 16 (a)
Species where no ortholog for BEND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEND2 Gene

Gene Tree for BEND2 (if available)
Gene Tree for BEND2 (if available)

Paralogs for BEND2 Gene

(6) SIMAP similar genes for BEND2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEND2: view

No data available for Paralogs for BEND2 Gene

Variants for BEND2 Gene

Sequence variations from dbSNP and Humsavar for BEND2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10126351 -- 18,198,385(+) aaagt(A/G)ggcaa intron-variant
rs11094738 -- 18,168,207(+) ATGGA(A/G)CAGCC intron-variant
rs111390586 -- 18,169,299(+) GGAGA(A/G/T)GGGAA intron-variant, downstream-variant-500B
rs111455888 -- 18,189,850(+) GAGAC(C/T)ATCCT intron-variant
rs111461610 -- 18,180,774(+) TACTC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BEND2 Gene

Variant ID Type Subtype PubMed ID
dgv2230e212 CNV loss 25503493
dgv2231e212 CNV gain 25503493
esv3573621 CNV loss 25503493
esv3573622 CNV loss 25503493
esv3573624 CNV loss 25503493
nsv510818 CNV deletion 20534489

Variation tolerance for BEND2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEND2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEND2 Gene

Disorders for BEND2 Gene

Relevant External Links for BEND2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BEND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND2 Gene

Publications for BEND2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Epileptic encephalopathy in a girl with an interstitial deletion of Xp22 comprising promoter and exon 1 of the CDKL5 gene. (PMID: 19455595) Bahi-Buisson N. … Bienvenu T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 64

Products for BEND2 Gene

Sources for BEND2 Gene

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