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Aliases for BEGAIN Gene

Aliases for BEGAIN Gene

  • Brain-Enriched Guanylate Kinase-Associated 2 3
  • Brain-Enriched Guanylate Kinase-Associated Homolog (Rat) 2
  • KIAA1446 4

External Ids for BEGAIN Gene

Summaries for BEGAIN Gene

GeneCards Summary for BEGAIN Gene

BEGAIN (Brain-Enriched Guanylate Kinase-Associated) is a Protein Coding gene. An important paralog of this gene is TJAP1.

UniProtKB/Swiss-Prot for BEGAIN Gene

  • May sustain the structure of the postsynaptic density (PSD)

Gene Wiki entry for BEGAIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEGAIN Gene

Genomics for BEGAIN Gene

Genomic Location for BEGAIN Gene

Start:
100,537,147 bp from pter
End:
100,587,413 bp from pter
Size:
50,267 bases
Orientation:
Minus strand

Genomic View for BEGAIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BEGAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEGAIN Gene

Regulatory Elements for BEGAIN Gene

Proteins for BEGAIN Gene

  • Protein details for BEGAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUH8-BEGIN_HUMAN
    Recommended name:
    Brain-enriched guanylate kinase-associated protein
    Protein Accession:
    Q9BUH8
    Secondary Accessions:
    • Q9NPU3
    • Q9P282

    Protein attributes for BEGAIN Gene

    Size:
    593 amino acids
    Molecular mass:
    64803 Da
    Quaternary structure:
    • Interacts with DLG4 and DLGAP1 and forms a ternary complex.
    SequenceCaution:
    • Sequence=BAA95970.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for BEGAIN Gene

Proteomics data for BEGAIN Gene at MOPED

Post-translational modifications for BEGAIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BEGAIN Gene

Domains for BEGAIN Gene

Protein Domains for BEGAIN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BEGAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BEGAIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BEGAIN Gene

Function for BEGAIN Gene

Molecular function for BEGAIN Gene

UniProtKB/Swiss-Prot Function: May sustain the structure of the postsynaptic density (PSD)

Gene Ontology (GO) - Molecular Function for BEGAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with BEGAIN: view

Phenotypes for BEGAIN Gene

genes like me logo Genes that share phenotypes with BEGAIN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BEGAIN Gene

Localization for BEGAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEGAIN Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEGAIN Gene COMPARTMENTS Subcellular localization image for BEGAIN gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BEGAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with BEGAIN: view

Pathways for BEGAIN Gene

SuperPathways for BEGAIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEGAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation --
genes like me logo Genes that share ontologies with BEGAIN: view

No data available for Pathways by source for BEGAIN Gene

Transcripts for BEGAIN Gene

Unigene Clusters for BEGAIN Gene

Brain-enriched guanylate kinase-associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEGAIN Gene

No ASD Table

Relevant External Links for BEGAIN Gene

GeneLoc Exon Structure for
BEGAIN
ECgene alternative splicing isoforms for
BEGAIN

Expression for BEGAIN Gene

mRNA expression in normal human tissues for BEGAIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEGAIN Gene

This gene is overexpressed in Brain - Cerebellum (6.9) and Brain - Cerebellar Hemisphere (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BEGAIN Gene

SOURCE GeneReport for Unigene cluster for BEGAIN Gene Hs.211751

genes like me logo Genes that share expressions with BEGAIN: view

No data available for mRNA Expression by UniProt/SwissProt for BEGAIN Gene

Orthologs for BEGAIN Gene

This gene was present in the common ancestor of animals.

Orthologs for BEGAIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEGAIN 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BEGAIN 35
  • 84.53 (n)
  • 82.25 (a)
BEGAIN 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BEGAIN 35
  • 91.27 (n)
  • 93.37 (a)
BEGAIN 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Begain 35
  • 86.75 (n)
  • 87.65 (a)
Begain 16
Begain 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BEGAIN 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BEGAIN 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Begain 35
  • 87.19 (n)
  • 89.12 (a)
chicken
(Gallus gallus)
Aves BEGAIN 35
  • 64.58 (n)
  • 69.62 (a)
BEGAIN 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BEGAIN 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia begain 35
  • 60.27 (n)
  • 62.76 (a)
zebrafish
(Danio rerio)
Actinopterygii BEGAIN 36
  • 42 (a)
OneToOne
si:dkey-174m14.3 35
  • 56.58 (n)
  • 50.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42324 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for BEGAIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEGAIN Gene

ENSEMBL:
Gene Tree for BEGAIN (if available)
TreeFam:
Gene Tree for BEGAIN (if available)

Paralogs for BEGAIN Gene

Paralogs for BEGAIN Gene

Selected SIMAP similar genes for BEGAIN Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BEGAIN: view

Variants for BEGAIN Gene

Sequence variations from dbSNP and Humsavar for BEGAIN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4072539 -- 100,539,558(+) CCACC(C/T)CACTC intron-variant
rs4073549 -- 100,543,867(+) TCCTC(C/T)GACAG reference, synonymous-codon
rs4073550 -- 100,544,027(+) CAGTC(A/G)CTCGA intron-variant
rs4073737 -- 100,549,099(-) TGGGG(C/T)GGCCA intron-variant
rs4073738 -- 100,549,043(-) GCCCG(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BEGAIN Gene

Variant ID Type Subtype PubMed ID
esv34023 CNV Loss 18971310
nsv521690 CNV Loss 19592680
dgv1980n71 CNV Loss 21882294
nsv902232 CNV Loss 21882294
nsv509548 CNV Insertion 20534489
nsv456427 CNV Loss 19166990
nsv902234 CNV Loss 21882294
dgv1981n71 CNV Loss 21882294
esv2749112 CNV Deletion 23290073
esv2749113 CNV Deletion 23290073
esv1740531 CNV Deletion 17803354
esv2749114 CNV Deletion 23290073
esv993981 CNV Deletion 20482838
esv2749115 CNV Deletion 23290073
esv2675262 CNV Deletion 23128226
esv2660432 CNV Deletion 23128226

Relevant External Links for BEGAIN Gene

HapMap Linkage Disequilibrium report
BEGAIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEGAIN Gene

Disorders for BEGAIN Gene

Relevant External Links for BEGAIN

Genetic Association Database (GAD)
BEGAIN
Human Genome Epidemiology (HuGE) Navigator
BEGAIN
genes like me logo Genes that share disorders with BEGAIN: view

No data available for UniProtKB/Swiss-Prot for BEGAIN Gene

Publications for BEGAIN Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. (PMID: 9756850) Deguchi M. … Takai Y. (J. Biol. Chem. 1998) 3 23
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48

Products for BEGAIN Gene

Sources for BEGAIN Gene

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