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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BEGAIN Gene

protein-coding   GIFtS: 49
GCID: GC14M101003

brain-enriched guanylate kinase-associated

(Previous name: brain-enriched guanylate kinase-associated homolog (rat)...)
 Explore 3 diseases affiliated with
BEGAIN via our new
 Human Malady Compendium 
Biological research products
for BEGAIN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Brain-Enriched Guanylate Kinase-Associated1 2
KIAA14461 3
Brain-Enriched Guanylate Kinase-Associated Homolog (Rat)1
Brain-Enriched Guanylate Kinase-Associated Homolog2
Brain-Enriched Guanylate Kinase-Associated Protein2

External Ids:    HGNC: 241631   Entrez Gene: 575962   Ensembl: ENSG000001830927   UniProtKB: Q9BUH83   

Export aliases for BEGAIN gene to outside databases

Previous GC identifers: GC14M100074 GC14M081184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8
Function: May sustain the structure of the postsynaptic density (PSD)

Gene Wiki entry for BEGAIN


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BEGAIN gene promoter:
         USF1   Ik-3   NF-kappaB   USF-1   NF-kappaB2   FOXO1a   Sox9   NF-kappaB1   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBEGAIN promoter sequence
   Search SABiosciences Chromatin IP Primers for BEGAIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BEGAIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

BEGAIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEGAIN gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M101003:  view genomic region     (about GC identifiers)

Start:
101,003,484 bp from pter      End:
101,053,750 bp from pter
Size:
50,267 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8 (See protein sequence)
Recommended Name: Brain-enriched guanylate kinase-associated protein  
Size: 593 amino acids; 64803 Da
Subunit: Interacts with DLG4 and DLGAP1 and forms a ternary complex (By similarity)
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=BAA95970.1; Type=Erroneous initiation;
Secondary accessions: Q9NPU3 Q9P282

Explore the universe of human proteins at neXtProt for BEGAIN: NX_Q9BUH8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUH8

  • BEGAIN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153003.1  NP_065887.1  

    ENSEMBL proteins: 
     ENSP00000347301   ENSP00000451380   ENSP00000451397   ENSP00000452157   ENSP00000452607  
     ENSP00000450722   ENSP00000451125   ENSP00000411124  

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    Novus Biologicals BEGAIN Protein
    Novus Biologicals BEGAIN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BEGAIN

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--


    BEGAIN for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BEGAIN


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BUH8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8
    Function: May sustain the structure of the postsynaptic density (PSD)

    miRNA
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    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-650 hsa-miR-340 hsa-miR-511 hsa-let-7g hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidBEGAIN 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0016301kinase activity ----


    BEGAIN for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BEGAIN:
     Decreased Salmonella enterica   Decreased viability 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BEGAIN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for BEGAIN (Q9BUH81, 2, 3 ENSP000003473014) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2875369 MINT-2875388 I2D: score=3 STRING: ENSP00000344782
    ABLIM1O146392, 3, ENSP000003381904MINT-66438 I2D: score=5 STRING: ENSP00000338190
    BAHD1Q8TBE02, 3, ENSP000003969764MINT-66517 I2D: score=5 STRING: ENSP00000396976
    ZNF417Q8TAU32, 3, ENSP000003113194MINT-66995 I2D: score=4 STRING: ENSP00000311319
    KIAA0408Q6ZU522, 3MINT-66776 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BEGAIN
    Search CenterWatch for drugs/clinical trials and news about BEGAIN / BEGIN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BEGAIN gene (2 alternative transcripts): 
    NM_001159531.1  NM_020836.3  

    Unigene Cluster for BEGAIN:

    Brain-enriched guanylate kinase-associated
    Hs.211751  [show with all ESTs]
    Unigene Representative Sequence: NM_001159531
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355173(uc001yhq.3) ENST00000556751(uc001yhp.3) ENST00000553553
    ENST00000556188 ENST00000554356 ENST00000557378 ENST00000554140 ENST00000554274
    ENST00000554747 ENST00000443071(uc010txa.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BEGAIN
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate BEGAIN (see all 21):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-650 hsa-miR-340 hsa-miR-511 hsa-let-7g hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidBEGAIN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BEGAIN (see all 4)
    OriGene shRNA RFP: BEGAIN
    OriGene siRNA: BEGAIN
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BEGAIN (see all 5)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BEGAIN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BEGAIN

    Additional cDNA sequence: 

    AL390162.1 BC002607.2 

    5 DOTS entries:

    DT.95264612  DT.40278890  DT.91741099  DT.40280937  DT.95199357 

    24/30 AceView cDNA sequences (see all 30):

    BC002607 NM_020836 AL043720 AL043723 BU728852 BF914356 BI546537 AI863388 
    CK819217 AW263480 AL390162 BM695411 BI256275 BX396824 AB040879 BG333264 
    BE260645 BM128192 BG331492 BX375561 BI601727 CK819216 BU727060 BF311186 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BEGAIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGCCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    BEGAIN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BEGAIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BEGAIN

    SOURCE GeneReport for Unigene cluster: Hs.211751
        SABiosciences Custom PCR Arrays for BEGAIN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEGAIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BEGAIN gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Begain1 , 5 brain-enriched guanylate kinase-associated1, 5 86.75(n)1
    87.65(a)1
      12 (59.98 cM)5
    3807851  NM_001163175.11  NP_001156647.11 
     1090321875 
    chicken
    (Gallus gallus)
    Aves BEGAIN1 brain-enriched guanylate kinase-associated homolog more 64.69(n)
    69.63(a)
      428909  XM_426464.3  XP_426464.2 
    lizard
    (Anolis carolinensis)
    Reptilia BEGAIN6
    --
    62(a)
    1 ↔ 1
    GL343270.1(720141-733034)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-174m14.31 si:dkey-174m14.3 56.34(n)
    51.35(a)
      563117  NM_001045010.1  NP_001038475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423246
    --
    8(a)
    1 → many
    3L(3472447-3510895)


    ENSEMBL Gene Tree for BEGAIN (if available)
    TreeFam Gene Tree for BEGAIN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BEGAIN gene
    TJAP12  
    1 SIMAP similar gene for BEGAIN using alignment to 7 protein entries:     BEGIN_HUMAN (see all proteins):
    TJAP1

    BEGAIN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/601 NCBI SNPs in BEGAIN are shown (see all 601    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458065941,2
    --101002991(+) ACTGCA/GGAAAG 2 -- int10--------
    rs1489726061,2
    --101003131(+) ATCCCG/TTGTGC 2 -- int10--------
    rs1471205901,2
    --101003156(+) CCTGCC/TGACAT 2 -- int10--------
    rs1175257461,2
    F,--101003247(+) GCAGCG/ACGCAG 2 -- int11Minor allele frequency- A:0.03EA 120
    rs71442361,2
    C,F,H,--101003365(+) ATGGGG/ATGTGA 2 -- int15Minor allele frequency- A:0.03NS EA WA 534
    rs1506908661,2
    C,--101003456(+) AAGGC-/AGGAGGAG 2 -- int10--------
    rs1885518581,2
    C,--101003461(+) AGGAGA/GAGGAG 2 -- int10--------
    rs1385134241,2
    --101003645(+) GGGGCA/GGAGAT 2 -- ut310--------
    rs1438445011,2
    --101003658(+) GCACCG/TGCCGC 2 -- ut310--------
    rs1463528691,2
    --101003667(+) GCACTA/GGGGCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for BEGAIN (101003484 - 101053750 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BEGAIN
         1 CNV: 47864
         1 Indel: 25343

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BEGAIN for disorders           About GeneDecksing

    3 diseases for BEGAIN:    About MalaCards
    hydranencephaly    ataxia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: BEGAIN (1 document)

    Export disorders for BEGAIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BEGAIN gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with BEGAIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. (PubMed id 9756850)1, 9 Deguchi M....Takai Y. (1998)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1 Elks C.E....Murray A. (2010)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57596 HGNC: 24163 AceView: KIAA1446 Ensembl:ENSG00000183092 euGenes: HUgn57596
    ECgene: BEGAIN H-InvDB: BEGAIN

    (According to HUGE)
    About This Section
    HUGE: KIAA1446

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BEGAIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BEGAIN gene:
    Search GeneIP for patents involving BEGAIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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