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BEGAIN Gene

protein-coding   GIFtS: 49
GCID: GC14M101003

Brain-Enriched Guanylate Kinase-Associated

(Previous name: brain-enriched guanylate kinase-associated homolog (rat))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Brain-Enriched Guanylate Kinase-Associated1 2
Brain-Enriched Guanylate Kinase-Associated Homolog (Rat)1
Brain-Enriched Guanylate Kinase-Associated Homolog2
Brain-Enriched Guanylate Kinase-Associated Protein2
KIAA14463

External Ids:    HGNC: 241631   Entrez Gene: 575962   Ensembl: ENSG000001830927   UniProtKB: Q9BUH83   

Export aliases for BEGAIN gene to outside databases

Previous GC identifers: GC14M100074 GC14M081184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BEGAIN Gene:
BEGAIN (brain-enriched guanylate kinase-associated) is a protein-coding gene. An important paralog of this gene is TJAP1.

UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8
Function: May sustain the structure of the postsynaptic density (PSD)

Gene Wiki entry for BEGAIN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BEGAIN gene promoter:
         USF1   Ik-3   NF-kappaB   USF-1   NF-kappaB2   FOXO1a   Sox9   NF-kappaB1   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBEGAIN promoter sequence
   Search Chromatin IP Primers for BEGAIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BEGAIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

BEGAIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEGAIN gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M101003:  view genomic region     (about GC identifiers)

Start:
101,003,484 bp from pter      End:
101,053,750 bp from pter
Size:
50,267 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8 (See protein sequence)
Recommended Name: Brain-enriched guanylate kinase-associated protein  
Size: 593 amino acids; 64803 Da
Subunit: Interacts with DLG4 and DLGAP1 and forms a ternary complex (By similarity)
Sequence caution: Sequence=BAA95970.1; Type=Erroneous initiation;
Secondary accessions: Q9NPU3 Q9P282

Explore the universe of human proteins at neXtProt for BEGAIN: NX_Q9BUH8

Explore proteomics data for BEGAIN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BEGAIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153003.1  NP_065887.1  

    ENSEMBL proteins: 
     ENSP00000347301   ENSP00000451380   ENSP00000451397   ENSP00000452157   ENSP00000452607  
     ENSP00000450722   ENSP00000451125   ENSP00000411124  

    BEGAIN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BEGAIN

     
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    antibodies-online proteins for BEGAIN (4 products) 

     
    antibodies-online peptides for BEGAIN

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    antibodies-online antibodies for BEGAIN (11 products) 

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    Cloud-Clone Corp. CLIAs for BEGAIN
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    antibodies-online kits for BEGAIN (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9BUH8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BEGIN_HUMAN, Q9BUH8
    Function: May sustain the structure of the postsynaptic density (PSD)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0016301kinase activity ----
         
    Find genes that share ontologies with BEGAIN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BEGAIN:
     Decreased Salmonella enterica   Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BEGAIN
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    Selected qRT-PCR Assays for microRNAs that regulate BEGAIN (see all 21):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-650 hsa-miR-340 hsa-miR-511 hsa-let-7g hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidBEGAIN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BEGAIN

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    Addgene plasmids for BEGAIN 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BEGIN_HUMAN, Q9BUH8: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with BEGAIN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BEGAIN
    Interactions:

        Search GeneGlobe Interaction Network for BEGAIN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BEGAIN (Q9BUH81, 2, 3 ENSP000003473014) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000215641P143732, 3MINT-67515 I2D: score=5 
    ENSG00000229006P143732, 3MINT-67515 I2D: score=5 
    ENSG00000234495P143732, 3MINT-67515 I2D: score=5 
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2875369 MINT-2875388 I2D: score=3 STRING: ENSP00000344782
    BAHD1Q8TBE02, 3, ENSP000003969764MINT-66517 I2D: score=5 STRING: ENSP00000396976
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BEGAIN (BEGIN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BEGAIN gene (2 alternative transcripts): 
    NM_001159531.1  NM_020836.3  

    Unigene Cluster for BEGAIN:

    Brain-enriched guanylate kinase-associated
    Hs.211751  [show with all ESTs]
    Unigene Representative Sequence: NM_001159531
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355173(uc001yhq.3) ENST00000556751(uc001yhp.3) ENST00000553553
    ENST00000556188 ENST00000554356 ENST00000557378 ENST00000554140 ENST00000554274
    ENST00000554747 ENST00000443071(uc010txa.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BEGAIN (see all 21):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-650 hsa-miR-340 hsa-miR-511 hsa-let-7g hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidBEGAIN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BEGAIN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BEGAIN
    Addgene plasmids for BEGAIN 
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    OriGene qPCR primer pairs and template standards for BEGAIN
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BEGAIN
      QuantiTect SYBR Green Assays in human, mouse, rat BEGAIN
      QuantiFast Probe-based Assays in human, mouse, rat BEGAIN

    Additional mRNA sequence: 

    AL390162.1 BC002607.2 

    5 DOTS entries:

    DT.95264612  DT.40278890  DT.91741099  DT.40280937  DT.95199357 

    Selected AceView cDNA sequences (see all 30):

    AL043720 NM_020836 AL043723 BC002607 BU728852 BM695411 BI256275 BI546537 
    BX396824 AI863388 BI601727 BG333264 AW263480 AL390162 BX375561 BE260645 
    BF914356 BM128192 BG331492 CK819217 AB040879 BI258808 BI260239 BF944415 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BEGAIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGCCAGT
    BEGAIN Expression
    About this image


    BEGAIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    BEGAIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BEGAIN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211751
        Custom PCR Arrays for BEGAIN
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BEGAIN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Begain1 , 5 brain-enriched guanylate kinase-associated1, 5 86.75(n)1
    87.65(a)1
      12 (59.98 cM)5
    3807851  NM_001163175.11  NP_001156647.11 
     1090321875 
    chicken
    (Gallus gallus)
    Aves BEGAIN1 brain-enriched guanylate kinase-associated homolog more 64.58(n)
    69.62(a)
      428909  XM_426464.4  XP_426464.3 
    lizard
    (Anolis carolinensis)
    Reptilia BEGAIN6
    brain-enriched guanylate kinase-associated
    57(a)
    1 ↔ 1
    GL343270.1(541960-733862)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia begain1 brain-enriched guanylate kinase-associated 60.27(n)
    62.76(a)
      100127687  NM_001113026.2  NP_001106497.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-174m14.31 si:dkey-174m14.3 56.58(n)
    50.36(a)
      563117  NM_001045010.1  NP_001038475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423246
    --
    8(a)
    1 → many
    3L(3472447-3510895)


    ENSEMBL Gene Tree for BEGAIN (if available)
    TreeFam Gene Tree for BEGAIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BEGAIN gene
    TJAP12  
    1 SIMAP similar gene for BEGAIN using alignment to 7 protein entries:     BEGIN_HUMAN (see all proteins):
    TJAP1

    Find genes that share paralogs with BEGAIN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BEGAIN (see all 755)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458065941,2
    C--101002991(+) ACTGCA/GGAAAG 2 -- int10--------
    rs1489726061,2
    --101003131(+) ATCCCG/TTGTGC 2 -- int10--------
    rs1471205901,2
    C--101003156(+) CCTGCC/TGACAT 2 -- int10--------
    rs1175257461,2
    C,F--101003247(+) GCAGCG/ACGCAG 2 -- int11Minor allele frequency- A:0.03EA 120
    rs71442361,2
    C,F,H--101003365(+) ATGGGG/ATGTGA 2 -- int15Minor allele frequency- A:0.03NS EA WA 534
    rs1506908661,2
    C--101003456(+) AAGGC-/AGGAGGAG 2 -- int10--------
    rs1885518581,2
    C--101003461(+) AGGAGA/GAGGAG 2 -- int10--------
    rs1385134241,2
    C--101003645(+) GGGGCA/GGAGAT 2 -- ut310--------
    rs1438445011,2
    --101003658(+) GCACCG/TGCCGC 2 -- ut310--------
    rs1463528691,2
    --101003667(+) GCACTA/GGGGCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for BEGAIN (101003484 - 101053750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BEGAIN (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660432CNV Deletion23128226
    esv2749112CNV Deletion23290073
    esv2675262CNV Deletion23128226
    esv2749115CNV Deletion23290073
    esv993981CNV Deletion20482838
    esv2749114CNV Deletion23290073
    esv2749113CNV Deletion23290073
    esv1740531CNV Deletion17803354
    nsv509548CNV Insertion20534489
    nsv902232CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with BEGAIN           About GenesLikeMe

    Genetic Association Database (GAD): BEGAIN
    Human Genome Epidemiology (HuGE) Navigator: BEGAIN (1 document)

    Export disorders for BEGAIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BEGAIN gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with BEGAIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. (PubMed id 9756850)1, 9 Deguchi M....Takai Y. (J. Biol. Chem. 1998)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57596 HGNC: 24163 AceView: KIAA1446 Ensembl:ENSG00000183092 euGenes: HUgn57596
    ECgene: BEGAIN H-InvDB: BEGAIN

    (According to HUGE)
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    HUGE: KIAA1446

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BEGAIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BEGAIN gene:
    Search GeneIP for patents involving BEGAIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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