BEGAIN Gene
protein-coding GIFtS : 49
GCID: GC14 M101003
brain-enriched guanylate kinase-associated (Previous name: brain-enriched guanylate kinase-associated homolog (rat)... )
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Aliasesfor BEGAIN gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Brain-Enriched Guanylate Kinase-Associated 1 2 KIAA14461 3 Brain-Enriched Guanylate Kinase-Associated Homolog (Rat)1 Brain-Enriched Guanylate Kinase-Associated Homolog2 Brain-Enriched Guanylate Kinase-Associated Protein2
Export aliases for BEGAIN gene to outside databases Previous GC identifers: GC14M100074 GC14M081184
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Summariesfor BEGAIN gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8 Function : May sustain the structure of the postsynaptic density (PSD)Gene Wiki entry for BEGAIN
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Genomic Viewsfor BEGAIN gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BEGAIN gene promoter: USF1 Ik-3 NF-kappaB USF-1 NF-kappaB2 FOXO1a Sox9 NF-kappaB1 Ik-1 FOXO1 Other transcription factors Search SABiosciences Chromatin IP Primers for BEGAIN Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat BEGAIN
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.2 BEGAIN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M101003: view genomic region
(about GC identifiers )
Start:
101,003,484 bp from pter
End:
101,053,750 bp from pter
Size:
50,267 bases
Orientation:
minus strand
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Proteinsfor BEGAIN gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8 (See
protein sequence )Recommended Name: Brain-enriched guanylate kinase-associated protein Size : 593 amino acids; 64803 Da
Subunit : Interacts with DLG4 and DLGAP1 and forms a ternary complex (By similarity)
Subcellular location : Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Sequence caution : Sequence=BAA95970.1; Type=Erroneous initiation;
Secondary accessions : Q9NPU3 Q9P282Explore the universe of human proteins at neXtProt for BEGAIN: NX_Q9BUH8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BUH8 BEGAIN Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001153003.1 NP_065887.1 ENSEMBL proteins: ENSP00000347301 ENSP00000451380 ENSP00000451397 ENSP00000452157 ENSP00000452607 ENSP00000450722 ENSP00000451125 ENSP00000411124 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
BEGAIN for ontologies About GeneDecksing BEGAIN Antibody Products: Assay Products for BEGAIN:
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Protein
Domains / Familiesfor BEGAIN gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9BUH8
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Functionfor BEGAIN gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: BEGIN_HUMAN, Q9BUH8 Function : May sustain the structure of the postsynaptic density (PSD)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BEGAIN (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BEGAIN (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): BEGAIN (NM_020836 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BEGAIN Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BEGAIN
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEGAIN
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
BEGAIN for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for BEGAIN :
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Pathways & Interactionsfor BEGAIN gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BEGAIN STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/48 Interacting proteins for BEGAIN (Q9BUH8 1 , 2 , 3 ENSP00000347301 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 48 )About this table
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Drugs & Compoundsfor BEGAIN gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for BEGAIN Search CenterWatch for drugs/clinical trials and news about BEGAIN / BEGIN
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Transcriptsfor BEGAIN gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for BEGAIN gene (2 alternative transcripts): NM_001159531.1 NM_020836.3 Unigene Cluster for BEGAIN:
Brain-enriched guanylate kinase-associated Hs.211751 [show with all ESTs ] Unigene Representative Sequence: NM_001159531 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000355173 (uc001yhq.3 ) ENST00000556751 (uc001yhp.3 ) ENST00000553553 ENST00000556188 ENST00000554356 ENST00000557378 ENST00000554140 ENST00000554274 ENST00000554747 ENST00000443071 (uc010txa.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BEGAIN (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BEGAIN (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): BEGAIN (NM_020836 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BEGAIN Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BEGAIN
Additional cDNA sequence: AL390162.1 BC002607.2
5 DOTS entries : DT.95264612 DT.40278890
DT.91741099 DT.40280937 DT.95199357 24/30 AceView cDNA sequences (see all 30 ):
BC002607 NM_020836 AL043720 AL043723 BU728852 BF914356 BI546537 AI863388 CK819217 AW263480 AL390162 BM695411 BI256275 BX396824 AB040879 BG333264 BE260645 BM128192 BG331492 BX375561 BI601727 CK819216 BU727060 BF311186 GeneLoc Exon Structure
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Expression for BEGAIN gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section BEGAIN expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCCTGCCAGT
About this image BEGAIN expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See BEGAIN Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for BEGAIN SOURCE GeneReport for Unigene cluster: Hs.211751 SABiosciences Custom PCR Arrays for BEGAIN Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for BEGAINBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat BEGAIN QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat BEGAIN QIAGEN QuantiFast Probe-based Assays in human , mouse , rat BEGAIN In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEGAIN
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Orthologsfor BEGAIN gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for BEGAIN gene from 5/16 species (see all 16 ) About this table
ENSEMBL Gene Tree for BEGAIN (if available)TreeFam Gene Tree for BEGAIN (if available)
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Paralogsfor BEGAIN gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for BEGAIN gene TJAP1 2 1 SIMAP similar gene for BEGAIN using alignment to 7 protein entries: BEGIN_HUMAN (see all proteins ):TJAP1
BEGAIN for paralogs About GeneDecksing
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Genomic Variantsfor BEGAIN gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for BEGAIN (101003484 - 101053750 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for BEGAIN 1 CNV : 47864 1 Indel : 25343
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing BEGAIN
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Disorders
/ Diseasesfor BEGAIN gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
BEGAIN for disorders About GeneDecksing 3 diseases for BEGAIN : About MalaCards hydranencephaly ataxia neuronitis Human Genome Epidemiology (HuGE) Navigator: BEGAIN (1 document)Export disorders for BEGAIN gene to outside databases
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Publicationsfor BEGAIN gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for BEGAIN gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with BEGAIN) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331) 1 , 2 , 3 Nagase T.... Ohara O. (2000) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. (PubMed id 9756850) 1 , 9 Deguchi M....Takai Y. (1998) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462) 1 Elks C.E....Murray A. (2010) Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068) 1 Hutchins J.R....Peters J.M. (2010)
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External Searches for BEGAIN gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BEGAIN gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing BEGAIN gene
(According to HUGE )
About This Section
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Specialized Databases showing BEGAIN gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for BEGAIN Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for BEGAIN gene: Search GeneIP for patents involving BEGAIN GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BEGAIN gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for BEGAIN OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for BEGAIN OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for BEGAIN OriGene Protein Over-expression Lysate for BEGAIN Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for BEGAIN Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BEGAIN OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BEGAIN Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for BEGAIN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for BEGAIN OriGene Custom Protein Services for BEGAIN OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BEGAIN QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing BEGAIN QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat BEGAIN QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat BEGAIN QIAGEN QuantiFast Probe-based Assays in human , mouse , rat BEGAIN QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat BEGAIN
Search Tocris compounds for BEGAIN
BEGAIN Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEGAIN
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BEGAIN
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