Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BEGAIN Gene

Aliases for BEGAIN Gene

  • Brain Enriched Guanylate Kinase Associated 2 3 5
  • Brain-Enriched Guanylate Kinase-Associated Homolog (Rat) 2
  • Brain-Enriched Guanylate Kinase-Associated 2
  • KIAA1446 4

External Ids for BEGAIN Gene

Previous GeneCards Identifiers for BEGAIN Gene

  • GC14M100074
  • GC14M101003
  • GC14M081184

Summaries for BEGAIN Gene

GeneCards Summary for BEGAIN Gene

BEGAIN (Brain Enriched Guanylate Kinase Associated) is a Protein Coding gene. GO annotations related to this gene include kinase activity. An important paralog of this gene is TJAP1.

UniProtKB/Swiss-Prot for BEGAIN Gene

  • May sustain the structure of the postsynaptic density (PSD).

Gene Wiki entry for BEGAIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEGAIN Gene

Genomics for BEGAIN Gene

Regulatory Elements for BEGAIN Gene

Enhancers for BEGAIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BEGAIN on UCSC Golden Path with GeneCards custom track

Promoters for BEGAIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BEGAIN on UCSC Golden Path with GeneCards custom track

Genomic Location for BEGAIN Gene

Chromosome:
14
Start:
100,537,147 bp from pter
End:
100,587,413 bp from pter
Size:
50,267 bases
Orientation:
Minus strand

Genomic View for BEGAIN Gene

Genes around BEGAIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEGAIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEGAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEGAIN Gene

Proteins for BEGAIN Gene

  • Protein details for BEGAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUH8-BEGIN_HUMAN
    Recommended name:
    Brain-enriched guanylate kinase-associated protein
    Protein Accession:
    Q9BUH8
    Secondary Accessions:
    • Q9NPU3
    • Q9P282

    Protein attributes for BEGAIN Gene

    Size:
    593 amino acids
    Molecular mass:
    64803 Da
    Quaternary structure:
    • Interacts with DLG4 and DLGAP1 and forms a ternary complex.
    SequenceCaution:
    • Sequence=BAA95970.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for BEGAIN Gene

Proteomics data for BEGAIN Gene at MOPED

Post-translational modifications for BEGAIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BEGAIN Gene

Domains & Families for BEGAIN Gene

Protein Domains for BEGAIN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BEGAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BEGAIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BEGAIN Gene

Function for BEGAIN Gene

Molecular function for BEGAIN Gene

UniProtKB/Swiss-Prot Function:
May sustain the structure of the postsynaptic density (PSD).
genes like me logo Genes that share phenotypes with BEGAIN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BEGAIN Gene

Localization for BEGAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEGAIN Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BEGAIN Gene COMPARTMENTS Subcellular localization image for BEGAIN gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for BEGAIN Gene

Pathways & Interactions for BEGAIN Gene

SuperPathways for BEGAIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEGAIN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BEGAIN Gene

Drugs & Compounds for BEGAIN Gene

No Compound Related Data Available

Transcripts for BEGAIN Gene

Unigene Clusters for BEGAIN Gene

Brain-enriched guanylate kinase-associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BEGAIN Gene

No ASD Table

Relevant External Links for BEGAIN Gene

GeneLoc Exon Structure for
BEGAIN
ECgene alternative splicing isoforms for
BEGAIN

Expression for BEGAIN Gene

mRNA expression in normal human tissues for BEGAIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEGAIN Gene

This gene is overexpressed in Brain - Cerebellum (x6.9) and Brain - Cerebellar Hemisphere (x5.9).

Protein differential expression in normal tissues from HIPED for BEGAIN Gene

This gene is overexpressed in Colon (37.8) and Heart (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BEGAIN Gene



SOURCE GeneReport for Unigene cluster for BEGAIN Gene Hs.211751

genes like me logo Genes that share expression patterns with BEGAIN: view

Protein tissue co-expression partners for BEGAIN Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BEGAIN Gene

Orthologs for BEGAIN Gene

This gene was present in the common ancestor of animals.

Orthologs for BEGAIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BEGAIN 35
  • 84.53 (n)
  • 82.25 (a)
BEGAIN 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BEGAIN 35
  • 91.27 (n)
  • 93.37 (a)
BEGAIN 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Begain 35
  • 86.75 (n)
  • 87.65 (a)
Begain 16
Begain 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Begain 35
  • 87.19 (n)
  • 89.12 (a)
oppossum
(Monodelphis domestica)
Mammalia BEGAIN 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BEGAIN 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BEGAIN 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves BEGAIN 35
  • 64.58 (n)
  • 69.62 (a)
BEGAIN 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BEGAIN 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia begain 35
  • 60.27 (n)
  • 62.76 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-174m14.3 35
  • 56.58 (n)
  • 50.36 (a)
BEGAIN 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42324 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for BEGAIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEGAIN Gene

ENSEMBL:
Gene Tree for BEGAIN (if available)
TreeFam:
Gene Tree for BEGAIN (if available)

Paralogs for BEGAIN Gene

Paralogs for BEGAIN Gene

(1) SIMAP similar genes for BEGAIN Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BEGAIN: view

Variants for BEGAIN Gene

Sequence variations from dbSNP and Humsavar for BEGAIN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140556 -- 100,570,121(+) CCAAC(A/C)TCAAT intron-variant, upstream-variant-2KB
rs7141087 -- 100,569,715(+) AAGTG(C/T)TCCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs7401025 -- 100,546,080(+) GGGAA(G/T)GGTCC intron-variant, utr-variant-5-prime
rs2753954 -- 100,586,673(+) cctgt(A/T)aaggg intron-variant
rs7492369 -- 100,554,463(+) CCTTC(C/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BEGAIN Gene

Variant ID Type Subtype PubMed ID
esv34023 CNV Loss 18971310
nsv521690 CNV Loss 19592680
dgv1980n71 CNV Loss 21882294
nsv902232 CNV Loss 21882294
nsv509548 CNV Insertion 20534489
nsv456427 CNV Loss 19166990
nsv902234 CNV Loss 21882294
dgv1981n71 CNV Loss 21882294
esv2749112 CNV Deletion 23290073
esv2749113 CNV Deletion 23290073
esv1740531 CNV Deletion 17803354
esv2749114 CNV Deletion 23290073
esv993981 CNV Deletion 20482838
esv2749115 CNV Deletion 23290073
esv2675262 CNV Deletion 23128226
esv2660432 CNV Deletion 23128226

Variation tolerance for BEGAIN Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.05; 90.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEGAIN Gene

HapMap Linkage Disequilibrium report
BEGAIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEGAIN Gene

Disorders for BEGAIN Gene

Relevant External Links for BEGAIN

Genetic Association Database (GAD)
BEGAIN
Human Genome Epidemiology (HuGE) Navigator
BEGAIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BEGAIN

No disorders were found for BEGAIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEGAIN Gene

Publications for BEGAIN Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. (PMID: 9756850) Deguchi M. … Takai Y. (J. Biol. Chem. 1998) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for BEGAIN Gene

Sources for BEGAIN Gene

Content