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Aliases for BECN2 Gene

Aliases for BECN2 Gene

  • Beclin 2 2 3
  • BECN1L1 3 4 6
  • Beclin 1, Autophagy Related, Pseudogene 1 2 3
  • Beclin-1 Autophagy-Related Pseudogene 1 3 4
  • Beclin-1-Like Protein 1 3 4
  • BECN1P1 3 4
  • Beclin-2 3

External Ids for BECN2 Gene

Previous Symbols for BECN2 Gene

  • BECN1P1

Summaries for BECN2 Gene

GeneCards Summary for BECN2 Gene

BECN2 (Beclin 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BECN2 Gene

  • Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BECN2 Gene

Genomics for BECN2 Gene

Genomic Location for BECN2 Gene

Start:
241,957,737 bp from pter
End:
241,959,062 bp from pter
Size:
1,326 bases
Orientation:
Plus strand

Genomic View for BECN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BECN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BECN2 Gene

No data available for Regulatory Elements for BECN2 Gene

Proteins for BECN2 Gene

  • Protein details for BECN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MW95-BECN2_HUMAN
    Recommended name:
    Beclin-2
    Protein Accession:
    A8MW95
    Secondary Accessions:
    • E9KNW0

    Protein attributes for BECN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    48153 Da
    Quaternary structure:
    • Interacts with ATG14, AMBRA1, UVRAG and PIK3C3/VPS34; interaction is not disrupted by starvation. Does not interact with KIAA0226/Rubicon. Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct.

neXtProt entry for BECN2 Gene

Proteomics data for BECN2 Gene at MOPED

Post-translational modifications for BECN2 Gene

No Post-translational modifications

Other Protein References for BECN2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BECN2 Gene

Domains for BECN2 Gene

Protein Domains for BECN2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BECN2_HUMAN
Family:
  • Belongs to the beclin family.:
    • A8MW95
genes like me logo Genes that share domains with BECN2: view

No data available for Gene Families for BECN2 Gene

Function for BECN2 Gene

Molecular function for BECN2 Gene

UniProtKB/Swiss-Prot Function: Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

Gene Ontology (GO) - Molecular Function for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23954414
genes like me logo Genes that share ontologies with BECN2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BECN2 Gene

Localization for BECN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BECN2 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BECN2: view

Pathways for BECN2 Gene

SuperPathways for BECN2 Gene

No Data Available

Interacting Proteins for BECN2 Gene

Selected Interacting proteins: A8MW95-BECN2_HUMAN for BECN2 Gene via UniProtKB

Symbol External ID(s) Details
GPRASP1

Gene Ontology (GO) - Biological Process for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IMP 23954414
GO:0008333 endosome to lysosome transport IMP 23954414
GO:1990172 G-protein coupled receptor catabolic process IPI 23954414
genes like me logo Genes that share ontologies with BECN2: view

No data available for Pathways by source for BECN2 Gene

Transcripts for BECN2 Gene

mRNA/cDNA for BECN2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BECN2 Gene

No ASD Table

Relevant External Links for BECN2 Gene

GeneLoc Exon Structure for
BECN2
ECgene alternative splicing isoforms for
BECN2

Expression for BECN2 Gene

mRNA expression in normal human tissues for BECN2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BECN2 Gene

mRNA Expression by UniProt/SwissProt for BECN2 Gene

A8MW95-BECN2_HUMAN
Tissue specificity: Present in fetal and adult brain (at protein level).
genes like me logo Genes that share expressions with BECN2: view

Orthologs for BECN2 Gene

Evolution for BECN2 Gene

ENSEMBL:
Gene Tree for BECN2 (if available)
TreeFam:
Gene Tree for BECN2 (if available)

No data available for Orthologs for BECN2 Gene

Paralogs for BECN2 Gene

No data available for Paralogs for BECN2 Gene

Variants for BECN2 Gene

Sequence variations from dbSNP and Humsavar for BECN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3851304 -- 241,958,494(-) GGTCC(A/C)TCTGG reference, missense
rs3851305 -- 241,957,750(+) GGCGG(C/G)AGTCA upstream-variant-2KB
rs3851306 -- 241,957,651(+) TAAGA(C/T)GACAT upstream-variant-2KB
rs3851307 -- 241,957,568(+) TAATC(C/G)CTGGT upstream-variant-2KB
rs3862972 -- 241,959,292(-) GAGGC(C/G)AGTGG downstream-variant-500B

Relevant External Links for BECN2 Gene

HapMap Linkage Disequilibrium report
BECN2

No data available for Structural Variations from Database of Genomic Variants (DGV) for BECN2 Gene

Disorders for BECN2 Gene

No disorders were found for BECN2 Gene.

No data available for UniProtKB/Swiss-Prot for BECN2 Gene

Publications for BECN2 Gene

  1. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PMID: 23954414) He C. … Levine B. (Cell 2013) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for BECN2 Gene

Sources for BECN2 Gene

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