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Aliases for BECN2 Gene

Aliases for BECN2 Gene

  • Beclin 2 2 3 5
  • Beclin-1 Autophagy-Related Pseudogene 1 3 4
  • Beclin-1-Like Protein 1 3 4
  • BECN1P1 3 4
  • BECN1L1 3 4
  • Beclin 1, Autophagy Related, Pseudogene 1 2
  • Beclin-2 3

External Ids for BECN2 Gene

Previous HGNC Symbols for BECN2 Gene

  • BECN1P1

Summaries for BECN2 Gene

GeneCards Summary for BECN2 Gene

BECN2 (Beclin 2) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Apelin signaling pathway. An important paralog of this gene is BECN1.

UniProtKB/Swiss-Prot for BECN2 Gene

  • Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

Additional gene information for BECN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BECN2 Gene

Genomics for BECN2 Gene

GeneHancer (GH) Regulatory Elements for BECN2 Gene

Promoters and enhancers for BECN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I241944 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.4 -12.9 -12879 1.3 HDAC1 IRF2 SAP130 ZFP64 ARID4B ZNF384 CEBPG ZBTB40 KMT2B E4F1 BECN2 GC01P241917
GH01I241964 Enhancer 0.7 Ensembl ENCODE 0.4 +7.2 7186 1 ATF1 CEBPB CREB1 ELF1 ATF2 CREM BECN2 CFL1P4
GH01I241988 Enhancer 0.8 ENCODE 0.3 +31.5 31548 1 PKNOX1 SMAD1 NFIB ZNF529 INSM2 FEZF1 ZNF2 GTF3C2 ZNF335 ZNF213 CFL1P4 BECN2
GH01I241990 Enhancer 0.8 ENCODE 0.3 +32.5 32467 0.2 PKNOX1 RFX5 GLIS2 ZNF366 RCOR1 FOS DEK ZNF362 SMARCC1 USF2 CFL1P4 BECN2
GH01I241933 Enhancer 0.6 ENCODE 0.3 -23.1 -23107 1.4 MXI1 STAT1 RFX1 INSM2 CEBPG ATF2 TEAD3 ATF4 RFX3 ZNF692 GC01P241917 BECN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BECN2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BECN2 Gene

Genomic Locations for BECN2 Gene
chr1:241,957,767-241,959,062
(GRCh38/hg38)
Size:
1,296 bases
Orientation:
Plus strand
chr1:242,121,039-242,122,364
(GRCh37/hg19)

Genomic View for BECN2 Gene

Genes around BECN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BECN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BECN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BECN2 Gene

Proteins for BECN2 Gene

  • Protein details for BECN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MW95-BECN2_HUMAN
    Recommended name:
    Beclin-2
    Protein Accession:
    A8MW95
    Secondary Accessions:
    • E9KNW0

    Protein attributes for BECN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    48153 Da
    Quaternary structure:
    • Homodimer (via coiled-coil domain) (PubMed:28218432). Interacts (via coiled-coil domain) with ATG14 (via coiled-coil domain); this interaction is tighter than BECN2 self-association (PubMed:23954414, PubMed:28218432). Interacts with AMBRA1, UVRAG and PIK3C3/VPS34; these interactions are not disrupted by starvation (PubMed:23954414). Does not interact with RUBCN (PubMed:23954414). Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct (PubMed:23954414).

    Three dimensional structures from OCA and Proteopedia for BECN2 Gene

neXtProt entry for BECN2 Gene

Post-translational modifications for BECN2 Gene

No Post-translational modifications

Other Protein References for BECN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BECN2 Gene

Domains & Families for BECN2 Gene

Gene Families for BECN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BECN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BECN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MW95

UniProtKB/Swiss-Prot:

BECN2_HUMAN :
  • Belongs to the beclin family.
Family:
  • Belongs to the beclin family.
genes like me logo Genes that share domains with BECN2: view

Function for BECN2 Gene

Molecular function for BECN2 Gene

UniProtKB/Swiss-Prot Function:
Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

Gene Ontology (GO) - Molecular Function for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23954414
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with BECN2: view

Phenotypes for BECN2 Gene

GenomeRNAi human phenotypes for BECN2:
genes like me logo Genes that share phenotypes with BECN2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BECN2 Gene

Localization for BECN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BECN2 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA --
GO:0005737 cytoplasm IEA --
GO:0031410 cytoplasmic vesicle IBA --
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA --
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA --
genes like me logo Genes that share ontologies with BECN2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for BECN2 Gene

Pathways & Interactions for BECN2 Gene

genes like me logo Genes that share pathways with BECN2: view

Pathways by source for BECN2 Gene

Interacting Proteins for BECN2 Gene

Gene Ontology (GO) - Biological Process for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0006914 autophagy IMP 23954414
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0008333 endosome to lysosome transport IEA,IMP 23954414
GO:0032258 NOT protein localization by the Cvt pathway IBA --
genes like me logo Genes that share ontologies with BECN2: view

No data available for SIGNOR curated interactions for BECN2 Gene

Drugs & Compounds for BECN2 Gene

No Compound Related Data Available

Transcripts for BECN2 Gene

mRNA/cDNA for BECN2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BECN2 Gene

No ASD Table

Relevant External Links for BECN2 Gene

GeneLoc Exon Structure for
BECN2
ECgene alternative splicing isoforms for
BECN2

Expression for BECN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BECN2 Gene

Protein differential expression in normal tissues from HIPED for BECN2 Gene

This gene is overexpressed in Serum (55.7) and Platelet (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BECN2 Gene



Protein tissue co-expression partners for BECN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BECN2 Gene:

BECN2

mRNA Expression by UniProt/SwissProt for BECN2 Gene:

A8MW95-BECN2_HUMAN
Tissue specificity: Present in fetal and adult brain (at protein level).
genes like me logo Genes that share expression patterns with BECN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BECN2 Gene

Orthologs for BECN2 Gene

Evolution for BECN2 Gene

ENSEMBL:
Gene Tree for BECN2 (if available)
TreeFam:
Gene Tree for BECN2 (if available)

No data available for Orthologs for BECN2 Gene

Paralogs for BECN2 Gene

Paralogs for BECN2 Gene

genes like me logo Genes that share paralogs with BECN2: view

Variants for BECN2 Gene

Sequence variations from dbSNP and Humsavar for BECN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000761912 -- 241,955,921(+) AAGTTAAGT/AAGT upstream_transcript_variant
rs1001483677 -- 241,959,482(+) C/T downstream_transcript_variant
rs1001829667 -- 241,959,264(+) T/G downstream_transcript_variant
rs1002895011 -- 241,958,344(+) A/G coding_sequence_variant, missense_variant
rs1003326168 -- 241,958,426(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for BECN2 Gene

Variant ID Type Subtype PubMed ID
dgv16e55 CNV gain 17911159
nsv1002309 CNV gain 25217958
nsv1008886 CNV gain 25217958
nsv947475 CNV duplication 23825009

Additional Variant Information for BECN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BECN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BECN2 Gene

Disorders for BECN2 Gene

Additional Disease Information for BECN2

No disorders were found for BECN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BECN2 Gene

Publications for BECN2 Gene

  1. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PMID: 23954414) He C … Levine B (Cell 2013) 2 3 4 58
  2. BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. (PMID: 28218432) Su M … Sinha SC (Protein science : a publication of the Protein Society 2017) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction. (PMID: 28515304) Zhong L … Xiong S (Journal of virology 2017) 3 58
  5. Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis. (PMID: 26929373) Dong X … Levine B (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 58

Products for BECN2 Gene

Sources for BECN2 Gene

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